diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0d7d7e1b87..196c61e6d1 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -43,6 +43,7 @@ release.
 - Modified tgocassisstitch to optionally allow either a outputprefix or an
   outputsuffix, both, or neither for naming convention purposes. [#5162](https://github.com/DOI-USGS/ISIS3/pull/5162)
 - Changed the default PCK load behavior to try and load mission specific PCKs, if that fails we default to the base PCKs [#5335](https://github.com/DOI-USGS/ISIS3/pull/5335)
+- Disabled option to use web=true when running spiceinit with HRSC images. [#5223](https://github.com/DOI-USGS/ISIS3/issues/5223)
 
 ### Added
 - Added rclone to run dependencies in meta.yaml [#5183](https://github.com/DOI-USGS/ISIS3/issues/5183)
diff --git a/isis/src/base/apps/spiceinit/spiceinit.cpp b/isis/src/base/apps/spiceinit/spiceinit.cpp
index 8ff35b9b63..e3b717af8d 100644
--- a/isis/src/base/apps/spiceinit/spiceinit.cpp
+++ b/isis/src/base/apps/spiceinit/spiceinit.cpp
@@ -614,6 +614,11 @@ namespace Isis {
     QString instrumentId =
         labels.findGroup("Instrument", Pvl::Traverse)["InstrumentId"][0];
 
+    if (instrumentId == "HRSC"){
+      QString msg = "Spice Server does not support MEX HRSC images. Please rerun spiceinit with local MEX data.";
+      throw IException(IException::User, msg, _FILEINFO_);
+    }
+
     QString url       = ui.GetString("URL") + "?mission=" + missionName +
                                               "&instrument=" + instrumentId;
     int port          = ui.GetInteger("PORT");
diff --git a/isis/src/base/apps/spiceinit/spiceinit.xml b/isis/src/base/apps/spiceinit/spiceinit.xml
index 4ebc794c28..0971210278 100644
--- a/isis/src/base/apps/spiceinit/spiceinit.xml
+++ b/isis/src/base/apps/spiceinit/spiceinit.xml
@@ -102,6 +102,15 @@
       "NADIR" options typically have less accuracy than reconstructed and smithed
       kernels which is why they are disabled by default.
     </p>
+    <p><b>Issues running HRSC using ISIS SPICE Web Service:</b> 
+    Currently HRSC images cannot be spiceinit'd using ISIS SPICE web services. 
+    This is due to the HRSC camera model relying on cube data to process
+    line scan times. When using the SPICE server, only the label is returned 
+    causing the camera model to fail initialization. In order to run spiceinit on 
+    HRSC images, download the MEX data locally. See download instructions at 
+    https://github.com/DOI-USGS/ISIS3/blob/dev/README.md#mission-specific-data-downloads.
+    </p> 
+
   </description>
 
   <category>
diff --git a/isis/tests/FunctionalTestsSpiceinit.cpp b/isis/tests/FunctionalTestsSpiceinit.cpp
index 3a97e0e2bd..9687fb577e 100644
--- a/isis/tests/FunctionalTestsSpiceinit.cpp
+++ b/isis/tests/FunctionalTestsSpiceinit.cpp
@@ -25,6 +25,7 @@ using json = nlohmann::json;
 #include "gmock/gmock.h"
 
 using namespace Isis;
+using ::testing::HasSubstr;
 
 static QString APP_XML = FileName("$ISISROOT/bin/xml/spiceinit.xml").expanded();
 
@@ -710,3 +711,84 @@ TEST_F(SmallCube, FunctionalTestSpiceinitCsminitRestorationOnFail) {
   EXPECT_PRED_FORMAT2(AssertPvlGroupEqual, csmInfoGroup, outputCube.group("CsmInfo"));
 }
 
+
+TEST(Spiceinit, TestSpiceinitHrscWebError) {
+
+  std::istringstream labelStrm(R"(
+    Object = IsisCube
+      Object = Core
+        StartByte   = 65537
+        Format      = Tile
+        TileSamples = 323
+        TileLines   = 409
+
+        Group = Dimensions
+          Samples = 2584
+          Lines   = 19632
+          Bands   = 1
+        End_Group
+
+        Group = Pixels
+          Type       = Real
+          ByteOrder  = Lsb
+          Base       = 0.0
+          Multiplier = 1.0
+        End_Group
+      End_Object
+
+      Group = Instrument
+        SpacecraftName            = "MARS EXPRESS"
+        InstrumentId              = HRSC
+        StartTime                 = 2019-01-16T13:11:27.926
+        StopTime                  = 2019-01-16T13:13:37.796
+        SpacecraftClockStartCount = 1/0495724211.25691
+        SpacecraftClockStopCount  = 1/0495724397.63935
+        MissionPhaseName          = ME_Phase_40
+        TargetName                = Mars
+        Summing                   = 2
+        FocalPlaneTemperature     = 8.9911 <degC>
+        LensTemperature           = 9.6028 <degC>
+        InstrumentTemperature     = 11.8457 <degC>
+      End_Group
+
+      Group = Archive
+        DataSetId   = MEX-M-HRSC-3-RDR-V3.0
+        DetectorId  = MEX_HRSC_P1
+        EventType   = MARS-REGIONAL-MAPPING-Im-Gl-Pf
+        OrbitNumber = 19029
+        ProductId   = HJ029_0000_P12.IMG
+      End_Group
+
+      Group = BandBin
+        Width  = 174.0 <nm>
+        Center = 675.0 <nm>
+      End_Group
+
+      Group = Kernels
+        NaifIkCode = -41217
+      End_Group
+    End_Object
+  End
+  )");
+
+  Pvl label;
+  labelStrm >> label;
+
+  QTemporaryFile tempFile;
+  tempFile.open();
+  Cube testCube;
+
+  testCube.fromLabel(tempFile.fileName() + ".cub", label, "rw");
+
+  QVector<QString> args = {"web=true"};
+  UserInterface options(APP_XML, args);
+  
+
+  try {
+    spiceinit(&testCube, options);
+    FAIL() << "Should throw an exception" << std::endl;
+  }
+  catch (IException &e) {
+    EXPECT_THAT(e.what(), HasSubstr("Spice Server does not support MEX HRSC images. Please rerun spiceinit with local MEX data."));
+  }
+}