Skip to content

Commit 1762c7d

Browse files
authored
VEP docs - pangenome protein function link does not work (#840)
1 parent 7dd386f commit 1762c7d

File tree

1 file changed

+3
-3
lines changed

1 file changed

+3
-3
lines changed

docs/htdocs/info/docs/tools/vep/script/vep_example.html

+3-3
Original file line numberDiff line numberDiff line change
@@ -478,11 +478,11 @@ <h3 id="PolyPhen_SIFT"> Missense deleteriousness predictions </h3>
478478

479479
<p> Although PolyPhen/SIFT scores are not directly available for alternative assemblies by using <a href="vep_options.html#opt_polyphen">--polyphen</a> and <a href="vep_options.html#opt_sift">--sift</a>, they can be retrieved via the <a href="vep_plugins.html#PolyPhen_SIFT">PolyPhen_SIFT plugin</a>. </p>
480480

481-
<p> Using our <a href="https://github.com/Ensembl/ensembl-variation/tree/main/nextflow/ProteinFunction" rel="external">ProteinFunction pipeline</a>, we ran <b>PolyPhen-2 2.2.3</b> and <b>SIFT 6.2.1</b> on the proteome sequences for GRCh38 and all HPRC assemblies (the protein FASTA files indicated in <a href="https://projects.ensembl.org/hprc/" rel="external">Ensembl HPRC data page</a>) and stored their results in a single SQLite file: <a href="http://ftp.ensembl.org/pub/current_variation/pangenomes/Human/homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db" rel="external"><kbd>homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db</kbd></a>.
481+
<p> Using our <a href="https://github.com/Ensembl/ensembl-variation/tree/main/nextflow/ProteinFunction" rel="external">ProteinFunction pipeline</a>, we ran <b>PolyPhen-2 2.2.3</b> and <b>SIFT 6.2.1</b> on the proteome sequences for GRCh38 and all HPRC assemblies (the protein FASTA files indicated in <a href="https://projects.ensembl.org/hprc/" rel="external">Ensembl HPRC data page</a>) and stored their results in a single SQLite file: <a href="https://ftp.ensembl.org/pub/current_variation/pangenomes/Human/homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db" rel="external"><kbd>homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db</kbd></a>.
482482

483483
<p> Pre-computed scores and predictions can be retrieved by downloading this file and running VEP with the <b>PolyPhen_SIFT plugin</b>: </p>
484484

485-
<pre class="code sh_sh">curl -O http://ftp.ensembl.org/pub/current_variation/pangenomes/Human/homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db
485+
<pre class="code sh_sh">curl -O https://ftp.ensembl.org/pub/current_variation/pangenomes/Human/homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db
486486
vep -i test.vcf --offline \
487487
--species homo_sapiens_gca009914755v4 \
488488
--cache_version 107 \
@@ -618,7 +618,7 @@ <h3> Additional annotations </h3>
618618
<tr>
619619
<td><a href="https://github.com/Ensembl/VEP_plugins/blob/main/PolyPhen_SIFT.pm" rel="external">PolyPhen_SIFT</a></td>
620620
<td>Retrieves PolyPhen and SIFT predictions from a SQLite database.</td>
621-
<td><a href="http://ftp.ensembl.org/pub/current_variation/pangenomes/Human/homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db"><kbd>homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db</kbd></a></td>
621+
<td><a href="https://ftp.ensembl.org/pub/current_variation/pangenomes/Human/homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db"><kbd>homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db</kbd></a></td>
622622
<td><kbd>--plugin PolyPhen_SIFT,db=homo_sapiens_pangenome_PolyPhen_SIFT_20240502.db</kbd></td>
623623
</tr>
624624
<tr>

0 commit comments

Comments
 (0)