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format-version: 1.2
data-version: dpo/releases/2025-02-13
date: 13:02:2025 11:13
subsetdef: abnormal_slim "Abnormal/normal slim"
subsetdef: absent_slim "Absent/present slim"
subsetdef: attribute_slim "Attribute slim"
subsetdef: camcur ""
subsetdef: camcur "camcur"
subsetdef: cell_quality "cell_quality"
subsetdef: cur "cur"
subsetdef: deprecated "warning of impending obsoletion"
subsetdef: do_not_annotate "do not annotate"
subsetdef: EmbDevSlim "EmbDevSlim"
subsetdef: fbcvsubset_mgiribbons "fbcvsubset_mgiribbons"
subsetdef: FlyTed "Testis slim"
subsetdef: FT_new "FlyTed temp subset for edit tracking purposes"
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: larval_OF "larval olfactory system"
subsetdef: lethal_phase "lethal phase terms"
subsetdef: RD "terms for rd test ontology"
subsetdef: relational_slim "Relational slim: types of quality that require an additional entity in order to exist"
subsetdef: ro-eco ""
subsetdef: value_slim "Value slim"
synonymtypedef: BRAIN_NAME_ABV "BrainName official abbreviation"
synonymtypedef: BRAND_NAME "BRAND NAME"
synonymtypedef: FORMULA "FORMULA"
synonymtypedef: InChI "InChI"
synonymtypedef: InChIKey "InChIKey"
synonymtypedef: INN "INN"
synonymtypedef: IUPAC_NAME "IUPAC NAME"
synonymtypedef: SMILES "SMILES"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: FlyBase miscellaneous CV
idspace: ns http://creativecommons.org/ns#
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl#
idspace: terms http://purl.org/dc/terms/
ontology: dpo.obo
property_value: IAO:0000700 FBcv:0000347
property_value: ns:attributionURL "http://dx.doi.org/10.1186/2041-1480-4-30" xsd:string
property_value: owl:versionInfo "2025-02-13" xsd:string
property_value: terms:creator "http://orcid.org/0000-0002-1373-1705" xsd:string
property_value: terms:creator "http://orcid.org/0000-0002-7073-9172" xsd:string
property_value: terms:creator "https://orcid.org/0000-0001-5948-3092" xsd:string
property_value: terms:creator "https://orcid.org/0000-0002-0027-0858" xsd:string
property_value: terms:description "An ontology for the description of Drosophila melanogaster phenotypes." xsd:string
property_value: terms:license "https://creativecommons.org/licenses/by/4.0/" xsd:string
property_value: terms:title "Drosophila Phenotype Ontology (DPO)" xsd:string
[Term]
id: FBcv:0000002
name: abnormal thermotaxis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in thermotaxis (GO:0043052). 'thermotaxis' is defined as: 'The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.'" [FBC:DOS, GOC:cab1, WB_REF:cgc467]
synonym: "thermotaxis behavior defective" EXACT []
synonym: "thermotaxis behaviour defective" EXACT []
synonym: "thermotaxis defective" EXACT []
is_a: FBcv:0000683 ! abnormal temperature response
[Term]
id: FBcv:0000006
name: male semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000375 ! semi-fertile
is_a: FBcv:0000376 ! male fertile
[Term]
id: FBcv:0000007
name: female semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000375 ! semi-fertile
is_a: FBcv:0000377 ! female fertile
[Term]
id: FBcv:0000008
name: modifier of variegation
namespace: phenotypic_class
def: "Genotype g1 is a modifier of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is significantly different from that caused by g2 alone." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "variegation" RELATED [FBC:DOS]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000316
name: homeotic
namespace: phenotypic_class
def: "Phenotype that is the partial or full transformation of one or more segments (FBbt:00000003) or segmental appendages from one identity to another. For example, in antennapedia an antenna is partially or fully transformed into a leg." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000324
name: abnormal dorsal/ventral axis specification
namespace: phenotypic_class
def: "Phenotype that is any abnormality in dorsal/ventral axis specification (GO:0009950). 'dorsal/ventral axis specification' is defined as: 'The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.'" [FBC:DOS, GOC:dph, GOC:go_curators, GOC:tb]
synonym: "dorsal-ventral polarity" RELATED [FBC:DOS]
synonym: "dorsal/ventral axis specification defective" EXACT []
is_a: FBcv:0000686 ! abnormal axis specification
[Term]
id: FBcv:0000325
name: neurogenic phenotype
namespace: phenotypic_class
def: "A phenotype that is an expansion of the developing embryonic nervous system at the expense of developing ventral epidermis." [FlyBase:FBrf0040185]
comment: Typically this is caused by and expansion of the population of neuroblasts at the expense of prospective epidermis, both of which originate in the ventral ectoderm.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
property_value: terms:contributor http://orcid.org/0000-0002-7073-9172
property_value: terms:date "2011-09-13T02:42:10Z" xsd:dateTime
[Term]
id: FBcv:0000347
name: phenotypic class
namespace: phenotypic_class
[Term]
id: FBcv:0000348
name: wild-type
namespace: phenotypic_class
def: "The canonical phenotype of a wild-type Drosophilid." [FBC:DOS]
is_a: FBcv:0000347 ! phenotypic class
disjoint_from: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000349
name: viable
namespace: phenotypic_class
def: "A phenotype that is survival to mature adulthood, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
comment: Note, this term should not be used with the qualifier 'partially'. Use semi-viable or semi-lethal instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000347 ! phenotypic class
[Term]
id: FBcv:0000350
name: partially lethal - majority live
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant proportion of animals in that population, but less that half, prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
subset: lethal_phase
synonym: "semi-viable" EXACT []
is_a: FBcv:0000349 ! viable
is_a: FBcv:0002015 ! partially lethal
[Term]
id: FBcv:0000351
name: lethal
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM]
comment: Note on usage: lethal is appropriate in cases where escaper adults are very rare. The lethal phase prior to becoming a mature adult may be further specified using children terms which specify stage.
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development
[Term]
id: FBcv:0000352
name: partially lethal - majority die
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a majority of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM, FBC:NB]
comment: Stages during which there is significant death prior to mature adulthood can be indicated using one or more stage qualifiers.
subset: lethal_phase
synonym: "semi-lethal" EXACT []
is_a: FBcv:0002015 ! partially lethal
[Term]
id: FBcv:0000353
name: cell lethal
namespace: phenotypic_class
def: "A phenotype that is a failure of mutant cells to survive." [FBC:DOS]
comment: Typically, this phenotype is assayed in clones of cells.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000354
name: visible
namespace: phenotypic_class
def: "A post-embryonic, macroscopic, anatomical phenotype." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000355
name: abnormal eye color
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eye color compared to wild-type." [FBC:DOS]
synonym: "eye color defective" EXACT []
synonym: "eye colour defective" EXACT []
is_a: FBcv:0000354 ! visible
[Term]
id: FBcv:0000356
name: abnormal body color
namespace: phenotypic_class
def: "A phenotype that is any abnormality in body color compared to wild-type." [FBC:DOS]
synonym: "body color defective" EXACT []
synonym: "body colour defective" EXACT []
is_a: FBcv:0000354 ! visible
[Term]
id: FBcv:0000357
name: abnormal size
namespace: phenotypic_class
def: "A phenotype that is any abnormality in the size of the whole body or some body part compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "size defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000358
name: decreased body size
namespace: phenotypic_class
def: "Phenotype that is a decrease in body size compared to identically raised wild-type controls." [FBC:DOS]
synonym: "reduced body size" EXACT []
synonym: "small body" EXACT []
is_a: FBcv:0000665 ! abnormal body size
is_a: FBcv:0007508 ! decreased size
[Term]
id: FBcv:0000359
name: decreased cell number
namespace: phenotypic_class
def: "Phenotype that is a decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth - there may be fewer cells in an otherwise normal volume of tissue." [FBC:DOS]
synonym: "reduced cell number" EXACT []
is_a: FBcv:0000709 ! abnormal cell number
[Term]
id: FBcv:0000360
name: decreased cell size
namespace: phenotypic_class
def: "Phenotype that is a decrease in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth of a tissue - there may be more cells in an otherwise normal volume of tissue." [FBC:DOS]
comment: Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells.
synonym: "reduced cell size" EXACT []
is_a: FBcv:0000428 ! abnormal cell size
[Term]
id: FBcv:0000361
name: increased body size
namespace: phenotypic_class
def: "Phenotype that is an increase in body size compared to identically raised wild-type controls." [FBC:DOS]
synonym: "large body" EXACT []
is_a: FBcv:0000665 ! abnormal body size
is_a: FBcv:0007507 ! increased size
[Term]
id: FBcv:0000362
name: increased cell number
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type." [FBC:DOS]
comment: This phenotype is not necessarily accompanied by overgrowth of a tissue - there may be more cells in an otherwise normal volume of tissue. It is not necessarily due to an increase in cell growth -it may be the result of an increase in the division rate at normal growth rates. It may not even be due to an increase in the cell division rate - a reduced rate of cell death while the division rate is normal could also achieve it.
is_a: FBcv:0000709 ! abnormal cell number
[Term]
id: FBcv:0000363
name: increased cell size
namespace: phenotypic_class
def: "Phenotype that is an increase in the size of cells compared to wild-type." [FBC:DOS]
comment: May be due to an increase in the cell growth rate or to a reduced rate of cell division along with a normal rate of cell growth.
is_a: FBcv:0000428 ! abnormal cell size
[Term]
id: FBcv:0000364
name: sterile
namespace: phenotypic_class
def: "A phenotype that is the inability to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000365
name: semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000366
name: female sterile
namespace: phenotypic_class
def: "A phenotype that is the inability of females to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note: this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead.
is_a: FBcv:0000364 ! sterile
[Term]
id: FBcv:0000367
name: female semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000365 ! semi-sterile
[Term]
id: FBcv:0000368
name: female sterile germline-dependent
namespace: phenotypic_class
def: "A phenotype of female sterility due to defects in the female germline." [FBC:DOS]
synonym: "female sterile germ-line-dependent" EXACT []
is_a: FBcv:0000366 ! female sterile
[Term]
id: FBcv:0000369
name: female sterile soma-dependent
namespace: phenotypic_class
def: "A phenotype of female sterility due to defects in somatic cells of the ovary (FBbt:00006030), or of the products of these cells (such as eggshell)." [FBC:DOS]
is_a: FBcv:0000366 ! female sterile
[Term]
id: FBcv:0000370
name: male sterile
namespace: phenotypic_class
def: "A phenotype that is the inability of males to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note - this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead.
is_a: FBcv:0000364 ! sterile
[Term]
id: FBcv:0000371
name: male semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000365 ! semi-sterile
[Term]
id: FBcv:0000372
name: male sterile germline-dependent
namespace: phenotypic_class
def: "A phenotype of male sterility due to defects in the male germline." [FBC:DOS]
synonym: "male sterile germ-line-dependent" EXACT []
is_a: FBcv:0000370 ! male sterile
[Term]
id: FBcv:0000373
name: male sterile soma-dependent
namespace: phenotypic_class
def: "A phenotype of male sterility due to defects in somatic cells of the testis (FBbt:00006031) or of the products of these cells." [FBC:DOS]
is_a: FBcv:0000370 ! male sterile
[Term]
id: FBcv:0000374
name: fertile
namespace: phenotypic_class
def: "A phenotype that is the ability to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000347 ! phenotypic class
[Term]
id: FBcv:0000375
name: semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000374 ! fertile
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000376
name: male fertile
namespace: phenotypic_class
def: "A phenotype that is the ability of males to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note - this term should not be used with the qualifier 'partially' - use male semi-sterile or male semi-fertile instead.
is_a: FBcv:0000374 ! fertile
[Term]
id: FBcv:0000377
name: female fertile
namespace: phenotypic_class
def: "A phenotype that is the ability of females to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note - this term should not be used with the qualifier 'partially' - use female semi-sterile or female semi-fertile instead.
is_a: FBcv:0000374 ! fertile
[Term]
id: FBcv:0000378
name: grandchildless
namespace: phenotypic_class
def: "A phenotype in which all offspring are sterile. Typically, this is due to maternal effect sterility resulting from defects in pole cell development." [ISBN:978-0-87969-321-3]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000379
name: enhancer of variegation
namespace: phenotypic_class
def: "Genotype g1 is an enhancer of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is greater than that caused by g2 alone." [FBC:DOS]
comment: Typically, g2 is a chromosomal aberration or an insertion.
is_a: FBcv:0000008 ! modifier of variegation
[Term]
id: FBcv:0000380
name: non-enhancer of variegation
namespace: phenotypic_class
def: "Genotype g1 is a non-enhancer of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not greater than that caused by g2 alone." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000381
name: suppressor of variegation
namespace: phenotypic_class
def: "Genotype g1 is a suppressor of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is less than that caused by to g2 alone." [FBC:DOS]
comment: Typically, g2 is a chromosomal aberration or an insertion.
is_a: FBcv:0000008 ! modifier of variegation
[Term]
id: FBcv:0000382
name: non-suppressor of variegation
namespace: phenotypic_class
def: "Genotype g1 is a non-suppressor of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not less than that caused by g2 alone." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000383
name: auxotroph
namespace: phenotypic_class
def: "A phenotype that is the inability to synthesize some organic compound that can be synthesized by wild-type animals, and that is required for normal growth and/or development." [http://en.wikipedia.org/wiki/Auxotrophic]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000384
name: abnormal aging
namespace: phenotypic_class
def: "Phenotype that is any abnormality in aging." [GOC:PO_curators]
subset: fbcvsubset_mgiribbons
synonym: "aging defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000385
name: short lived
namespace: phenotypic_class
def: "Phenotype that is a shorter adult life-span than wild-type." [FBC:DOS]
subset: lethal_phase
synonym: "increased adult mortality" EXACT []
is_a: FBcv:0002004 ! increased mortality
[Term]
id: FBcv:0000386
name: long lived
namespace: phenotypic_class
def: "Phenotype that is a longer adult life-span than wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000387
name: abnormal behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in behavior (GO:0007610). 'behavior' is defined as: 'The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.'" [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
subset: fbcvsubset_mgiribbons
synonym: "behavior defective" EXACT []
synonym: "behavioral" RELATED []
synonym: "behaviour defective" EXACT []
synonym: "behavioural" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000388
name: abnormal gravitaxis
namespace: phenotypic_class
def: "Phenotype that is a change in the strong tendency, seen in wild-type Drosophila melanogaster, to climb - a behavior otherwise known as negative gravitaxis (GO:0048060 ; movement away from the source of gravity)." [FBC:DOS]
comment: Note, this term should not be used when flies have climbing defects purely as a consequence of locomotion defects, use 'locomotor behavior defective' instead.
subset: fbcvsubset_mgiribbons
synonym: "geotaxis behaviour defective" RELATED []
synonym: "gravitaxis behavior defective" RELATED []
synonym: "gravitaxis defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000389
name: paralytic
namespace: phenotypic_class
def: "Phenotype that is a disposition to paralysis under conditions that do not cause paralysis in a wild-type animal. Paralysis is defined as an inability to exhibit `multicellular organismal movement` (GO:0050879)" [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000390
name: decreased rate of movement
namespace: phenotypic_class
def: "A phenotype consisting of an decrease in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "hypoactive" EXACT []
synonym: "reduced rate of movement" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000391
name: bang sensitive
namespace: phenotypic_class
def: "A phenotype exhibited following mechanical shock and consisting of a brief period of intense, uncoordinated motor activity (legs and wings flailing, abdomen coiling) followed by a prolonged period of paralysis." [FlyBase:FBrf0022877]
synonym: "easily shocked" RELATED [FlyBase:FBrf0022877]
is_a: FBcv:0000389 ! paralytic
[Term]
id: FBcv:0000392
name: increased rate of movement
namespace: phenotypic_class
def: "A phenotype consisting of an increase in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "hyperactive" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000393
name: abnormal pain response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to pain (GO:0048265). 'response to pain' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.'" [FBC:DOS, GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
synonym: "pain response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
[Term]
id: FBcv:0000394
name: abnormal circadian rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian rhythm (GO:0007623). 'circadian rhythm' is defined as: 'Any biological process in an organism that recurs with a regularity of approximately 24 hours.'" [FBC:DOS, GOC:bf, GOC:go_curators]
subset: fbcvsubset_mgiribbons
synonym: "circadian rhythm defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000395
name: abnormal locomotor rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in locomotor rhythm (GO:0045475). 'locomotor rhythm' is defined as: 'The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.'" [FBC:DOS, GOC:go_curators]
synonym: "locomotor rhythm defective" EXACT []
is_a: FBcv:0000414 ! abnormal locomotor behavior
is_a: FBcv:0000679 ! abnormal circadian behavior
[Term]
id: FBcv:0000396
name: abnormal eclosion rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eclosion rhythm (GO:0008062). 'eclosion rhythm' is defined as: 'The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.'" [FBC:DOS, PMID:11715043]
synonym: "eclosion rhythm defective" EXACT []
is_a: FBcv:0000670 ! abnormal eclosion
is_a: FBcv:0000679 ! abnormal circadian behavior
[Term]
id: FBcv:0000397
name: abnormal learning
namespace: phenotypic_class
def: "Phenotype that is any abnormality in learning (GO:0007612). 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [FBC:DOS, ISBN:0582227089, ISBN:0721662544]
synonym: "learning defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000398
name: abnormal memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in memory (GO:0007613). 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:DOS, GOC:curators, ISBN:0582227089]
synonym: "memory defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000399
name: abnormal courtship behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'" [FBC:DOS, GOC:ai, GOC:dph]
synonym: "courtship behavior defective" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior
[Term]
id: FBcv:0000400
name: abnormal mating
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mating (GO:0007618). 'mating' is defined as: 'The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.'" [FBC:DOS, GOC:jl, ISBN:0387520546]
subset: fbcvsubset_mgiribbons
synonym: "mating defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000401
name: abnormal mating rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian mating behavior (GO:0035648). 'circadian mating behavior' is defined as: 'The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.'" [FBC:DOS, GOC:bf, GOC:dos, PMID:11470898, PMID:17276917]
synonym: "mating rhythm defective" EXACT []
is_a: FBcv:0000679 ! abnormal circadian behavior
is_a: FBcv:0000721 ! abnormal mating behavior
[Term]
id: FBcv:0000402
name: abnormal song
namespace: phenotypic_class
def: "Phenotype that is any abnormality in male courtship behavior, veined wing generated song production (GO:0045433). This is defined as 'The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.'" [FBC:DOS, GOC:mtg_sensu, PMID:11092827]
synonym: "singing defective" EXACT [FBC:SM]
synonym: "song defective" EXACT []
synonym: "song production defective" EXACT [FBC:SM]
is_a: FBcv:0000399 ! abnormal courtship behavior
[Term]
id: FBcv:0000403
name: abnormal chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [FBC:DOS, GOC:go_curators]
synonym: "abnormal chemosensitive behavior" EXACT []
synonym: "chemosensitive behavior defective" EXACT []
synonym: "chemosensitive behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000404
name: abnormal smell perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of smell (GO:0007608). 'sensory perception of smell' is defined as: 'The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.'" [FBC:DOS, GOC:ai]
synonym: "olfaction defective" EXACT []
synonym: "smell perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception
[Term]
id: FBcv:0000405
name: abnormal taste perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of taste (GO:0050909). 'sensory perception of taste' is defined as: 'The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.'" [FBC:DOS, GOC:ai]
synonym: "gustation defective" EXACT []
synonym: "taste defective" EXACT []
synonym: "taste perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception
[Term]
id: FBcv:0000406
name: abnormal tarsal response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in or absense of proboscis extension reflex in response to a sugar stimulus via taste sensilla on the tarsus." [FBC:DOS]
synonym: "tarsal response defective" EXACT []
is_a: FBcv:0000680 ! abnormal proboscis extension reflex
[Term]
id: FBcv:0000407
name: abnormal auditory perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of sound (GO:0007605). 'sensory perception of sound' is defined as: 'The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.'" [FBC:DOS, GOC:ai]
synonym: "auditory perception defective" EXACT []
synonym: "auditory system defective" RELATED []
is_a: FBcv:0000681 ! abnormal sensory perception
[Term]
id: FBcv:0000408
name: abnormal stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to stress (GO:0006950). 'response to stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).'" [FBC:DOS, GOC:mah]
subset: fbcvsubset_mgiribbons
synonym: "environmental stress response defective" NARROW []
synonym: "stress response defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000409
name: abnormal osmotic stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to osmotic stress (GO:0006970). 'response to osmotic stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.'" [FBC:DOS, GOC:jl]
synonym: "osmotic stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
[Term]
id: FBcv:0000410
name: abnormal heat stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to heat (GO:0009408). 'response to heat' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.'" [FBC:DOS, GOC:lr]
synonym: "heat stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
is_a: FBcv:0000683 ! abnormal temperature response
[Term]
id: FBcv:0000411
name: abnormal visual behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in visual behavior (GO:0007632). 'visual behavior' is defined as: 'The behavior of an organism in response to a visual stimulus.'" [FBC:DOS, GOC:jid, GOC:pr]
synonym: "visual behavior defective" EXACT []
synonym: "visual behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000412
name: abnormal optomotor response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in optomotor response: a motor response during flight or walking that serves to stabilize both image formation on the retina and locomotor course." [FBC:DOS]
synonym: "optomotor behaviour defective" EXACT []
synonym: "optomotor response defective" EXACT []
is_a: FBcv:0000411 ! abnormal visual behavior
[Term]
id: FBcv:0000413
name: abnormal phototaxis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:DOS, GOC:jl, ISBN:0192800981]
subset: fbcvsubset_mgiribbons
synonym: "phototaxis behaviour defective" RELATED []
synonym: "phototaxis defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000414
name: abnormal locomotor behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'" [FBC:DOS, GOC:dph]
synonym: "locomotor behavior defective" EXACT []
synonym: "locomotor behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000415
name: abnormal jumping
namespace: phenotypic_class
def: "Phenotype that is a reduced ability to jump or a reduced jump response. This may be due to neurological or muscular defects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "jumping defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000416
name: uncoordinated
namespace: phenotypic_class
def: "Phenotype that is abnormal co-ordination of motor activity." [FBC:CP, FBC:DOS]
is_a: FBcv:0000414 ! abnormal locomotor behavior
[Term]
id: FBcv:0000417
name: abnormal flight
namespace: phenotypic_class
def: "Phenotype that is any abnormality in flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.'" [FBC:DOS, GOC:dph]
comment: This term is agnostic as to the causes of defects in flight. An animal's flight may be defective for mechanical, behavioral or sensory reasons.
subset: fbcvsubset_mgiribbons
synonym: "flight behaviour defective" NARROW []
synonym: "flight defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000418
name: flightless
namespace: phenotypic_class
def: "Phenotype that is the absence of flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.'" [FBC:DOS, GOC:dph]
comment: This term is agnostic as to the causes of flightlessness. An animal may be flightless for mechanical or behavioral reasons.
is_a: FBcv:0000417 ! abnormal flight
[Term]
id: FBcv:0000419
name: abnormal feeding behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in feeding behavior (GO:0007631). 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
synonym: "feeding behavior defective" EXACT []
synonym: "feeding behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000420
name: abnormal grooming behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'" [FBC:DOS, GOC:jl, GOC:pr]
synonym: "grooming behavior defective" EXACT []
synonym: "grooming behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000421
name: abnormal touch response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in or loss of a stereotypical behavioral response to touch." [FlyBase:FBrf0073546]
comment: This phenotype is commonly assayed by scoring larval avoidance responses following stroking of the thoracic segments (see Kernan et al., 1994). On its own, this is not sufficient evidence for an abnormality in sensory perception of touch, as motor defects can also cause this phenotype.
synonym: "touch response defective" EXACT []
synonym: "touch sensitivity defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000422
name: photoperiod response variant
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entrainment of circadian clock by photoperiod (GO:0043153), which is defined as: 'The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).'" [FBC:DOS, GOC:jl]
is_a: FBcv:0000387 ! abnormal behavior
[Term]
id: FBcv:0000423
name: abnormal DNA repair
namespace: phenotypic_class
def: "Phenotype that is any abnormality in DNA repair (GO:0006281). 'DNA repair' is defined as: 'The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.'" [FBC:DOS, PMID:11563486]
synonym: "DNA repair defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
[Term]
id: FBcv:0000424
name: abnormal cell death
namespace: phenotypic_class
def: "Phenotype that is a change in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. This may be due to effects on the regulation of cell death (GO:0010941) or in cell death (GO:0008219) pathways themselves." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "apoptosis defective" NARROW []
synonym: "cell death defective" EXACT []
synonym: "pcd defective" NARROW []
synonym: "programmed cell death defective" NARROW []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000425
name: increased cell death
namespace: phenotypic_class
def: "Phenotype that is an increase in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "pcd increase" NARROW []
synonym: "programmed cell death increase" NARROW []
is_a: FBcv:0000424 ! abnormal cell death
[Term]
id: FBcv:0000426
name: decreased cell death
namespace: phenotypic_class
def: "Phenotype that is a decrease in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "pcd decrease" NARROW []
synonym: "programmed cell death decrease" NARROW []
synonym: "reduced cell death" EXACT []
is_a: FBcv:0000424 ! abnormal cell death
[Term]
id: FBcv:0000427
name: abnormal cell growth
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell growth (GO:0016049). 'cell growth' is defined as: 'The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.'" [FBC:DOS, GOC:ai]
comment: Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells.
subset: fbcvsubset_mgiribbons
synonym: "cell growth defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000428
name: abnormal cell size
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell size defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000429
name: abnormal cell shape
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the shape (PATO:0000052) of some cell compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell shape defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000430
name: abnormal cell polarity
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the asymmetric distribution of components within a cell. For example an epithelial cell is 'cell polarity defective' if it lacks the normal asymmetric distribution of proteins or cell components such as junctions or villi along its apical-basal axis." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell polarity defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000431
name: abnormal meiotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in meiotic cell cycle (GO:0051321). 'meiotic cell cycle' is defined as: 'Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.'" [FBC:DOS, GOC:ai]
synonym: "meiotic" RELATED []
synonym: "meiotic cell cycle defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle
[Term]
id: FBcv:0000432
name: abnormal mitotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mitotic cell cycle (GO:0000278). 'mitotic cell cycle' is defined as: 'Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.'" [FBC:DOS, GOC:mah, ISBN:0815316194]
synonym: "mitotic" RELATED []
synonym: "mitotic cell cycle defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle
[Term]
id: FBcv:0000433
name: abnormal cytokinesis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cytokinesis (GO:0000910). 'cytokinesis' is defined as: 'The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.'" [FBC:DOS, GOC:mtg_cell_cycle]
synonym: "cytokinesis defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle
[Term]
id: FBcv:0000434
name: abnormal neurophysiology
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the electrophysiological properties of some class of neurons, muscles or other anatomical structure of the nervous system. Examples of these phenotypes at the neuron class level include defects in spontaneous or evoked excitatory junction potential. Examples at a more gross anatomical level include abnormal retinal electrophysiology (e.g.- measured by an electroretinogram)." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "neurophysiology defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000435
name: abnormal neuroanatomy
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the anatomy of the nervous system (FBbt:00005093). 'nervous system' is defined as: 'All the nerve centers and nerve fibers in the central, visceral and peripheral nervous systems.'" [FBC:DOS, FlyBase:FBrf0166419]
subset: fbcvsubset_mgiribbons
synonym: "neuroanatomy defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000436
name: abnormal sex-determination
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sex determination (GO:0007530). 'sex determination' is defined as: 'Any process that establishes and transmits the specification of sexual status of an individual organism.'" [FBC:DOS, ISBN:0198506732]
subset: fbcvsubset_mgiribbons
synonym: "sex-determination defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000437
name: obsolete dosage compensation defective
namespace: phenotypic_class
comment: This term was obsoleted because it was felt that the evidence provided in papers is not enough to annotate with this term. mc161014
is_obsolete: true
consider: FBcv:0000436
[Term]
id: FBcv:0000438
name: electrophoretic variant
namespace: phenotypic_class
def: "Phenotype that is a difference in electrophoretic migration of a gene product compared to wild-type." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000439
name: chemical resistant
namespace: phenotypic_class
def: "Phenotype that is a decreased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000440
name: chemical sensitive
namespace: phenotypic_class
def: "Phenotype that is an increased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000441
name: radiation resistant
namespace: phenotypic_class
def: "Phenotype that is a decreased tendency for radiation exposure to cause toxic effects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000442
name: radiation sensitive
namespace: phenotypic_class
def: "Phenotype that is an increased tendency for radiation exposure to cause toxic effects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000443
name: Minute
namespace: phenotypic_class
def: "Dominant phenotype consisting of short slender bristles and delayed development. Homozygotes are cell lethal." [FlyBase:FBrf0066905]
comment: The phenotype may be a general result of mutations in essential components of the protein synthesis pathway, as a number of Minutes encode ribosomal proteins. In an animal that is heterozygous for a Minute mutation, cells with two wild-type alleles of the affected gene have a growth advantage. Many developmental studies take advantage of this fact to give somatic clones a growth advantage. The term 'Minute' should not be used to annotate the resulting phenotypes.
is_a: FBcv:0000450 ! abnormal developmental rate
[Term]
id: FBcv:0000444
name: hyperplasia
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of cells in a tissue or organ, usually associated with an increase in size, where the affected tissue or organ maintains its normal form." [ISBN:978-0-19-850673-7]
synonym: "hyperplastic" EXACT []
is_a: FBcv:0000362 ! increased cell number
[Term]
id: FBcv:0000445
name: obsolete tumorigenic
namespace: phenotypic_class
def: "Phenotype that is characterized by the formation of abnormal masses of tissue (tumors) as the result of neoplasia." [FBC:DOS]
comment: Obsoleted as this is the same phenotype as neoplasia.
is_obsolete: true
replaced_by: FBcv:0000723
[Term]
id: FBcv:0000446
name: melanotic mass phenotype
namespace: phenotypic_class
def: "Phenotype characterized by the formation of lumps of melanotic tissue inside the body in the absence of foreign bodies or wounding." [FlyBase:FBrf0094387, FlyBase:FBrf0194475]
comment: Melanotic capsules are formed around wounds and foreign bodies in wild-type animals as part of the immune response, for example as a protection against parasitoid wasps. For the wild-type structure, consider FBbt:00005064. Some, but not all melanotic mass phenotypes involve ectopic activation of the same immune response. Melanotic masses caused by genetic manipulations are sometimes referred to as 'melanotic tumors' or 'pseudotumors', but this is a misnomer as they are rarely neoplastic (Minakhina and Steward, 2006).
synonym: "melanization" NARROW [FlyBase:FBrf0194475]
synonym: "melanotic nodule" NARROW [FlyBase:FBrf0194475]
synonym: "melanotic tumor" RELATED [FlyBase:FBrf0194475]
synonym: "pseudotumor" RELATED [FlyBase:FBrf0194475]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000447
name: melanotic necrosis
namespace: phenotypic_class
def: "Phenotype characterized by closely associated necrosis and melanization." [FlyBase:FBrf0155704]
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000448
name: abnormal immune response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in immune response (GO:0006955). 'immune response' is defined as: 'Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.'" [FBC:DOS, GO_REF:0000022, GOC:add]
subset: fbcvsubset_mgiribbons
synonym: "immune response defective" EXACT []
is_a: FBcv:0001347 ! phenotype
[Term]
id: FBcv:0000449