diff --git a/.flake8 b/.flake8
deleted file mode 100644
index 16598a700..000000000
--- a/.flake8
+++ /dev/null
@@ -1,3 +0,0 @@
-[flake8]
-max-line-length = 99
-ignore = E731,E203
diff --git a/.github/workflows/python-check.yaml b/.github/workflows/python-check.yaml
new file mode 100644
index 000000000..f8fecd2f1
--- /dev/null
+++ b/.github/workflows/python-check.yaml
@@ -0,0 +1,127 @@
+name: Python Check
+run-name: "${{ github.actor }} checking Python code"
+
+permissions:
+  contents: read
+  pull-requests: read
+
+on:
+  pull_request:
+    branches: [ main, develop ]
+  workflow_dispatch:
+
+jobs:
+  pre-check:
+    runs-on: ubuntu-latest
+    outputs:
+      is_act: ${{ steps.detect_act.outputs.is_act }}
+    steps:
+      - name: Detect act environment
+        id: detect_act
+        uses: Framework-R-D/phlex/.github/actions/detect-act-env@main
+
+  detect-changes:
+    needs: pre-check
+    if: github.event_name != 'workflow_dispatch' && needs.pre-check.outputs.is_act != 'true'
+    runs-on: ubuntu-latest
+    permissions:
+      contents: read
+      packages: read
+    outputs:
+      has_changes: ${{ steps.filter.outputs.matched }}
+    steps:
+    - name: Checkout code
+      uses: actions/checkout@1af3b93b6815bc44a9784bd300feb67ff0d1eeb3 # v6.0.0
+      with:
+        fetch-depth: 0
+        path: phlex-src
+
+    - name: Detect Python changes
+      id: filter
+      uses: Framework-R-D/phlex/.github/actions/detect-relevant-changes@main
+      with:
+        repo-path: phlex-src
+        base-ref: ${{ github.event_name == 'pull_request' && github.event.pull_request.base.sha || github.event.before }}
+        head-ref: ${{ github.event_name == 'pull_request' && github.event.pull_request.head.sha || github.sha }}
+        file-type: python
+
+    - name: Report detection outcome
+      run: |
+        if [ "${{ steps.filter.outputs.matched }}" != "true" ]; then
+          echo "::notice::No python check relevant changes detected; job will be skipped."
+        else
+          echo "::group::Python check relevant files"
+          printf '%s\n' "${{ steps.filter.outputs.matched_files }}"
+          echo "::endgroup::"
+        fi
+
+  python-check:
+    needs: [pre-check, detect-changes]
+    if: >
+      github.event_name == 'workflow_dispatch' ||
+      needs.pre-check.outputs.is_act == 'true' ||
+      (needs.detect-changes.result == 'success' && needs.detect-changes.outputs.has_changes == 'true')
+    runs-on: ubuntu-latest
+    permissions:
+      contents: read
+
+    steps:
+    - name: Checkout code
+      uses: actions/checkout@1af3b93b6815bc44a9784bd300feb67ff0d1eeb3 # v6.0.0
+      with:
+        path: phlex-src
+
+    - name: Set up Python
+      uses: actions/setup-python@e797f83bcb11b83ae66e0230d6156d7c80228e7c # v6.0.0
+      with:
+        python-version: '3.x'
+
+    - name: Install Python dependencies
+      run: |
+        pip install ruff mypy
+
+    - name: Run ruff and mypy checks
+      working-directory: phlex-src
+      env:
+        FORCE_COLOR: 1  # `ruff`/`colored` crate
+      run: |
+        failed=0
+
+        echo "➡️ Checking Python code with ruff..."
+        echo "::group::Running ruff check"
+        if ! ruff check; then
+          failed=1
+          echo "::endgroup::"
+          echo "::error:: Ruff check failed."
+        else
+          echo "::endgroup::"
+          echo "✅ Ruff check passed."
+        fi
+
+        echo "➡️ Checking Python code with mypy..."
+        echo "::group::Running mypy"
+        if ! mypy --color-output .; then
+          failed=1
+          echo "::endgroup::"
+          echo "::error:: MyPy check failed."
+        else
+          echo "::endgroup::"
+          echo "✅ MyPy check passed."
+        fi
+
+        exit $failed
+
+  python-check-skipped:
+    needs: [pre-check, detect-changes]
+    if: >
+      github.event_name != 'workflow_dispatch' &&
+      needs.pre-check.outputs.is_act != 'true' &&
+      needs.detect-changes.result == 'success' &&
+      needs.detect-changes.outputs.has_changes != 'true'
+    runs-on: ubuntu-latest
+    permissions:
+      contents: read
+
+    steps:
+    - name: No relevant Python changes detected
+      run: echo "No Python relevant changes detected; check skipped."
diff --git a/.github/workflows/python-fix.yaml b/.github/workflows/python-fix.yaml
new file mode 100644
index 000000000..d7f1e6ff1
--- /dev/null
+++ b/.github/workflows/python-fix.yaml
@@ -0,0 +1,73 @@
+name: Python Fix
+run-name: "${{ github.actor }} fixing Python code"
+
+on:
+  issue_comment:
+    types:
+      - created
+
+permissions:
+  pull-requests: write
+  contents: write
+
+jobs:
+  apply_fixes:
+    runs-on: ubuntu-latest
+    name: Apply fixes
+    if: |
+      github.event.issue.pull_request &&
+      (github.event.comment.author_association == 'COLLABORATOR' || github.event.comment.author_association == 'OWNER') &&
+      startsWith(github.event.comment.body, '@phlexbot python-fix')
+    steps:
+      - name: Get PR Info
+        id: get_pr
+        uses: Framework-R-D/phlex/.github/actions/get-pr-info@main
+
+      - uses: actions/checkout@1af3b93b6815bc44a9784bd300feb67ff0d1eeb3 # v6.0.0
+        with:
+          path: phlex-src
+          ref: ${{ steps.get_pr.outputs.ref }}
+          repository: ${{ steps.get_pr.outputs.repo }}
+          token: ${{ secrets.WORKFLOW_PAT }}
+
+      - name: Set up Python
+        uses: actions/setup-python@e797f83bcb11b83ae66e0230d6156d7c80228e7c # v6.0.0
+        with:
+          python-version: '3.x'
+
+      - name: Install Python dependencies
+        run: |
+          pip install ruff
+
+      - name: Run ruff format and fix
+        working-directory: phlex-src
+        env:
+          FORCE_COLOR: 1
+        run: |
+          echo "Fixing Python format with ruff"
+          ruff format . || true
+          echo "Fixing Python linter issues with ruff"
+          ruff check --fix . || true
+
+      - uses: EndBug/add-and-commit@a94899bca583c204427a224a7af87c02f9b325d5 # v9.1.4
+        id: add_and_commit
+        with:
+          token: ${{ secrets.WORKFLOW_PAT }}
+          cwd: phlex-src
+          author_name: "github-actions[bot]"
+          author_email: "41898282+github-actions[bot]@users.noreply.github.com"
+          message: 'Committing Python linting fixes'
+
+      - name: Formatting changes committed and pushed
+        if: ${{ steps.add_and_commit.outputs.committed == 'true' && steps.add_and_commit.outputs.pushed == 'true'}}
+        uses: thollander/actions-comment-pull-request@24bffb9b452ba05a4f3f77933840a6a841d1b32b # v3.0.1
+        with:
+          message: |
+            Python linting fixes pushed (commit ${{ steps.add_and_commit.outputs.commit_sha }})
+
+      - name: No formatting changes to make
+        if: ${{ steps.add_and_commit.outputs.committed == 'false' }}
+        uses: thollander/actions-comment-pull-request@24bffb9b452ba05a4f3f77933840a6a841d1b32b # v3.0.1
+        with:
+          message: |
+            No Python linting fixes to make
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 000000000..9357828e5
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,34 @@
+[tool.mypy]
+ignore_missing_imports = true
+no_implicit_optional = true
+plugins = [
+]
+show_error_codes = true
+warn_unreachable = true
+disable_error_code = "annotation-unchecked"
+
+[tool.ruff]
+target-version = "py310"
+line-length = 99
+
+[tool.ruff.lint]
+select = [
+  "B",  # flake8-bugbear
+  "C4", # flake8-comprehensions
+  "D",  # pydocstyle
+  "E",  # pycodestyle errors
+  "F",  # pyflakes
+  "I",  # isort
+  "W",  # pycodestyle warnings
+]
+ignore = []
+extend-ignore = [
+    "E731", # do not assign a lambda expression, use a def
+    "E203", # whitespace before ':'
+]
+
+[tool.ruff.lint.pydocstyle]
+convention = "google"
+
+[tool.ruff.format]
+quote-style = "double"