diff --git a/Formula/wine.rb b/Formula/wine.rb
new file mode 100644
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--- /dev/null
+++ b/Formula/wine.rb
@@ -0,0 +1,126 @@
+# NOTE: When updating Wine, please make sure to match Wine-Gecko and Wine-Mono
+# versions:
+#  - https://wiki.winehq.org/Gecko
+#  - https://wiki.winehq.org/Mono
+# with `GECKO_VERSION` and `MONO_VERSION`, as in:
+#    https://source.winehq.org/git/wine.git/blob/refs/tags/wine-9.0:/dlls/appwiz.cpl/addons.c
+class Wine < Formula
+  desc "Run Windows applications without a copy of Microsoft Windows"
+  homepage "https://www.winehq.org/"
+  url "https://dl.winehq.org/wine/source/9.0/wine-9.0.tar.xz"
+  sha256 "7cfd090a5395f5b76d95bb5defac8a312c8de4c070c1163b8b58da38330ca6ee"
+  head "https://gitlab.winehq.org/wine/wine.git",
+    branch: "master"
+
+  depends_on "bison" => :build
+  depends_on "mingw-w64" => :build
+  depends_on "pkg-config" => :build
+  depends_on arch: :x86_64
+  depends_on "freetype"
+  depends_on "gettext"
+  depends_on "gnutls"
+  depends_on "gstreamer"
+  depends_on "libpcap"
+  depends_on :macos
+  depends_on "sdl2"
+
+  uses_from_macos "flex" => :build
+
+  on_macos do
+    depends_on "libinotify-kqueue"
+    depends_on "molten-vk"
+  end
+
+  resource "gecko-x86" do
+    url "https://dl.winehq.org/wine/wine-gecko/2.47.4/wine-gecko-2.47.4-x86.tar.xz"
+    sha256 "2cfc8d5c948602e21eff8a78613e1826f2d033df9672cace87fed56e8310afb6"
+  end
+
+  resource "gecko-x86_64" do
+    url "https://dl.winehq.org/wine/wine-gecko/2.47.4/wine-gecko-2.47.4-x86_64.tar.xz"
+    sha256 "fd88fc7e537d058d7a8abf0c1ebc90c574892a466de86706a26d254710a82814"
+  end
+
+  def install
+    # Bypass the Homebrew shims to build native binaries with the dedicated compiler.
+    # (PE binaries will be built with mingw32-gcc.)
+    compiler_options = ["CC=clang",
+                        "CXX=clang++"]
+
+    # We also need to tell the linker to add Homebrew to the rpath stack.
+    ENV.append "LDFLAGS", "-lSystem"
+    ENV.append "LDFLAGS", "-L#{HOMEBREW_PREFIX}/lib"
+    ENV.append "LDFLAGS", "-Wl,-rpath,#{HOMEBREW_PREFIX}/lib"
+
+    # Common compiler flags for both Mach-O and PE binaries.
+    ENV.append_to_cflags "-g -O2 -Wno-deprecated-declarations"
+    # Use an older deployment target to avoid new dyld behaviors.
+    ENV["MACOSX_DEPLOYMENT_TARGET"] = "10.14"
+
+    wine_configure_options = ["--prefix=#{prefix}",
+                              "--disable-tests",
+                              "--enable-archs=i386,x86_64",
+                              "--enable-win64",
+                              "--without-alsa",
+                              "--without-capi",
+                              "--with-coreaudio",
+                              "--with-cups",
+                              "--without-dbus",
+                              "--with-freetype",
+                              "--with-gettext",
+                              "--without-gettextpo",
+                              "--without-gphoto",
+                              "--with-gnutls",
+                              "--without-gssapi",
+                              "--with-gstreamer",
+                              "--with-inotify",
+                              "--without-krb5",
+                              "--with-mingw",
+                              "--without-netapi",
+                              "--with-opencl",
+                              "--with-opengl",
+                              "--without-oss",
+                              "--with-pcap",
+                              "--with-pthread",
+                              "--without-pulse",
+                              "--without-sane",
+                              "--with-sdl",
+                              "--without-udev",
+                              "--with-unwind",
+                              "--without-usb",
+                              "--without-v4l2",
+                              "--with-vulkan",
+                              "--without-x"]
+
+    # Build
+    mkdir buildpath/"wine64-build" do
+      system buildpath/"configure", *wine_configure_options, *compiler_options
+      system "make"
+    end
+
+    # Install
+    cd "wine64-build" do
+      system "make", "install-lib"
+    end
+  end
+
+  def post_install
+    # Homebrew replaces wine's rpath names with absolute paths, we need to change them back to @rpath relative paths
+    # Wine relies on @rpath names to cause dlopen to always return the first dylib with that name loaded into
+    # the process rather than the actual dylib found using rpath lookup.
+    Dir["#{lib}/wine/x86_64-unix/*.so"].each do |dylib|
+      chmod 0664, dylib
+      MachO::Tools.change_dylib_id(dylib, "@rpath/#{File.basename(dylib)}")
+      MachO.codesign!(dylib)
+      chmod 0444, dylib
+    end
+
+    # Install wine-gecko into place
+    (share/"wine"/"gecko"/"wine-gecko-2.47.4-x86").install resource("gecko-x86")
+    (share/"wine"/"gecko"/"wine-gecko-2.47.4-x86_64").install resource("gecko-x86_64")
+  end
+
+  test do
+    system bin/"wine", "--version"
+  end
+end