fig-8b.hoc

load_file("nrngui.hoc")
cvode_active(1)

Vrest = -65
dt = 0.05
celsius = 34.0
freq=50

Rm = 41358
Cm    = 0.85
RaAll= 634
ghd=0.0001
ghdd=0	
ehd=-30

tstop=200

xopen("geo-cell1zr.hoc")
xopen("fixnseg.hoc")           

objref s, nc, syn, pd, ps, psn, pdn

pd = new Vector()
ps = new Vector()
psn = new Vector()
pdn = new Vector()

access soma

soma {
	s = new NetStim(.5)
	s.start=5
	s.interval=1000
	s.number=5

	syn = new Exp2Syn(.5)
	syn.tau1=.4
	syn.tau2=5
	syn.e=0
}

nc = new NetCon(s, syn, 0, 0, 0.05e-3)

forall { 
	insert pas
	insert ds
	insert hd ehd_hd=ehd ghdbar_hd=ghdd

	e_pas=Vrest 
	g_pas = 1/Rm 
	Ra=RaAll 
	cm=Cm
}

	geom_nseg()
	tot=0
	forall {tot=tot+nseg}

	access soma
	distance()

proc init() {
	finitialize(Vrest)
        fcurrent()
        forall for (z,0) {
		ghdbar_hd(z)=ghdd
		e_pas(z)=v(z)+i_hd(z)/g_pas
	}
	cvode.re_init()
}

proc runl() {
ff=50 
if (flag>0) {ghdd=ghd} else {ghdd=0}
print " running with Ih=",ghdd
for (mind=0; mind<650; mind=mind+100) {
	pd.resize(0)
	ps.resize(0)
	psn.resize(0)
	forsec "apical" for(gg,0) {if (distance(gg)>mind && distance(gg)<mind+100) {
	syn.loc(gg)
	s.interval=1000
	run()
	ref=soma.vmax_ds(.5)-Vrest
	refd=vmax_ds(gg)-Vrest
	s.interval=1000/ff
	run()
	pd.append(vmax_ds(gg)-Vrest)
	pdn.append((vmax_ds(gg)-Vrest)/refd)
	ps.append(soma.vmax_ds(gg)-Vrest)
	psn.append((soma.vmax_ds(gg)-Vrest)/ref)
	}
	}
	print " avr soma summ ", psn.mean()," +/- ", psn.stderr(), " at ", mind+50, "um"  
}
}

flag=0
xpanel(" ")
xbutton(" run ", "runl()") 
xcheckbox(" with Ih ",&flag)
xpanel()