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kinetics.hoc
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kinetics.hoc
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create a
a {nseg=1 diam=5 L=5
insert kargc ek=-85
insert pas g_pas=1/10000 Ra=150 cm=1}
access a
tstop=100
vlow=-100
vhigh=30
dt=0.01
objref gk, b,gt,vc, gs,c, gf,ic
b = new VBox()
c = new VBox()
b.intercept(1)
gk = new Graph(0)
gk.view(vlow,0,vhigh-vlow,1,0,0,100,200)
gk.exec_menu("New Axis")
gk.exec_menu("10% Zoom out")
gk.label(0.1,0.9,"Fig.9B-9D: steady-states")
gk.addexpr("minf_kargc",3,2, 2*tstop,0,2)
gk.addexpr("hinf_kargc",2,2, 2*tstop,0,2)
gt = new Graph(0)
gt.view(vlow,0,vhigh-vlow,5,0,0,100,200)
gt.exec_menu("New Axis")
gt.exec_menu("10% Zoom out")
gt.label(0.1,0.9,"time constants")
gt.addexpr("mtau_kargc",3,2, 2*tstop,0,2)
gt.addexpr("htau_kargc/5",2,2, 2*tstop,0,2)
xpanel("")
xbutton("run ", "run()")
xpanel()
b.intercept(0)
b.map("K kinetics for RGC",100,0,200,400)
c.intercept(1)
gs = new Graph(0)
gs.view(0,0,tstop,600,0,0,100,200)
gs.exec_menu("New Axis")
gs.exec_menu("10% Zoom out")
gs.label(0.1,0.9,"current (pA), Fig.8B, step from -100mV")
gs.exec_menu("Keep Lines")
c.intercept(0)
c.map("activation",390,0,500,370)
vc = new SEClamp(0.5)
proc run() {
gk.begin()
for (v=vlow; v<vhigh; v=v+1) {
trates_kargc(v)
gk.plot(v)
}
gk.flush()
doNotify()
gt.begin()
gt.color(2)
gt.label(0.1,0.75,"tau_inact./5")
gt.color(3)
gt.label(0.15,0.5,"tau_act.")
for (v=vlow; v<vhigh; v=v+1) {
trates_kargc(v)
gt.plot(v)
}
gt.flush()
doNotify()
gbar_kargc=0.01
gs.color(2)
gs.label(0.6,0.3,"-30")
gs.color(4)
gs.label(0.6,0.4,"-10")
gs.color(6)
gs.label(0.6,0.5,"10")
gs.color(7)
gs.label(0.6,0.6,"20")
gs.begin()
k=-40
color=1
while (k<21) {
gs.addexpr("ik*area(0.5)*10",color,1, 2*tstop,0,2) // *10=pA, *1e-2=nA
t=0
vc.amp1=-100
vc.dur1=0.2
vc.amp2=k
vc.dur2=tstop
forall {finitialize(vc.amp1)}
while (t<tstop) {
fadvance()
gs.plot(t)
}
gs.flush()
doNotify()
k=k+10
color=color+1
gs.begin()
}
}