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| 1 | +--- |
| 2 | +layout: poster |
| 3 | +title: "Methods for decoding cortical gradients of functional connectivity" |
| 4 | +nickname: 2024-04-01-peraza-gradient-decoding-gsaw |
| 5 | +authors: "Peraza JA, Salo T, Riedel MC, Bottenhorn KL, Poline J-B, Dockès J, Kent JD, Bartley JE, Flannery JS, Hill-Bowen LD, Lobo RP, Poudel R, Ray KL, Robinson JL, Laird RW, Sutherland MT, de la Vega A, Laird AR" |
| 6 | +year: "2024" |
| 7 | +conference: "GSAW" |
| 8 | +image: /assets/images/posters/2024-04-01-peraza-gradient-decoding-gsaw.png |
| 9 | +projects: ["mmmm"] |
| 10 | +tags: [] |
| 11 | + |
| 12 | +# Content |
| 13 | +fulltext: |
| 14 | +pdf: https://osf.io/6grs3 |
| 15 | + |
| 16 | +# Links |
| 17 | +doi: |
| 18 | + |
| 19 | +# Data and code |
| 20 | +github: |
| 21 | +neurovault: |
| 22 | +openneuro: |
| 23 | +figshare: |
| 24 | +figshare_names: |
| 25 | +osf: |
| 26 | +f1000: |
| 27 | +--- |
| 28 | + |
| 29 | +{% include JB/setup %} |
| 30 | + |
| 31 | +# Abstract |
| 32 | + |
| 33 | +## Background |
| 34 | + |
| 35 | +- Macroscale gradients of brain connectivity have emerged as a central principle for understanding functional brain organization. |
| 36 | +- The functional significance and interpretation of gradients remain a central topic of discussion in the neuroimaging community. |
| 37 | +- Previous studies have demonstrated that the gradients may be described using meta-analytic functional decoding techniques. |
| 38 | +- However, additional methodological development is necessary to fully leverage available meta-analytic methods and resources and quantitatively evaluate their relative performance. |
| 39 | + |
| 40 | +## Goals |
| 41 | + |
| 42 | +**Overall Objective:** investigate and improve the framework of data-driven methods for decoding the principal gradient of functional connectivity. |
| 43 | + |
| 44 | +- Examine and evaluate different methods for decoding brain maps on surface space. |
| 45 | +- Establish a principled approach for gradient segmentation and meta-analytic decoding. |
| 46 | +- Provide recommendations on best practices and develop flexible methods for gradient-based functional decoding. |
| 47 | + |
| 48 | +## Methods |
| 49 | + |
| 50 | +We used the resting-state fMRI (rs-fMRI) group-average dense connectome from the Human Connectome Project (HCP) S1200 data release to identify the principal gradient of functional connectivity. We evaluated three segmentation approaches: (i) percentile-based, (ii) segmentation based on a 1D k-means clustering approach, and (iii) segmentation based on the Kernel Density Estimation curve of the gradient axis. We assessed six different decoding strategies that used two meta-analytic databases (i.e., Neurosynth and NeuroQuery) and three methods to produce meta-analytic maps (i.e., term-based, LDA-based, and GC-LDA-based decoding). In addition, we proposed a method for decoding lower-order gradient maps combined with the principal gradient in a high-dimensional space. |
| 51 | + |
| 52 | +## Results |
| 53 | + |
| 54 | +- For small numbers of segments, a k-means algorithm yields the most confident distribution of boundaries, as shown by the silhouette coefficients, variance ratio, and cluster separation. |
| 55 | +- LDA-based produced meta-analytic maps that yielded a relatively high correlation value and a collection of terms that naturally improved the information content, TFIDF, and SNR. |
| 56 | +- NS and NQ performed similarly regarding their correlation profile. |
| 57 | +- We reproduced the results from Margulies et al., showing the continuous transition from primary sensorimotor to transmodal regions. |
| 58 | +- We proposed methods for decoding lower-order gradient maps. |
| 59 | + |
| 60 | +## Conclusions |
| 61 | + |
| 62 | +- We found that a two-segment solution determined by a k-means segmentation approach and an LDA-based meta-analysis combined with the NeuroQuery database was the optimal combination of methods for decoding the principal gradient of functional connectivity. |
| 63 | +- This combination of approaches and our recommended visualization method for reporting meta-analytic decoding findings will enhance the overall interpretability of macroscale gradients in the fMRI community. |
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