diff --git a/doc/userguide/capture-hardware/pcap-file.rst b/doc/userguide/capture-hardware/pcap-file.rst
index d5ed628dde36..2d0dde98ca15 100644
--- a/doc/userguide/capture-hardware/pcap-file.rst
+++ b/doc/userguide/capture-hardware/pcap-file.rst
@@ -33,6 +33,10 @@ This can improve performance, especially for large files.
 The size can be specified through the command line option, see
 :ref:`--pcap-file-buffer-size <cmdline-option-pcap-file-buffer-size>`
 
+Setting ``buffer-size`` to ``0`` disables ``setvbuf`` buffering. This is the
+explicit opt-out for non-seekable sources such as ``/dev/stdin`` or named
+pipes, where buffering the underlying file descriptor is not supported.
+
 Directory-related options
 -------------------------
 
diff --git a/doc/userguide/partials/options.rst b/doc/userguide/partials/options.rst
index 5264db813337..bcbca0f62206 100644
--- a/doc/userguide/partials/options.rst
+++ b/doc/userguide/partials/options.rst
@@ -103,7 +103,8 @@
 .. option:: --pcap-file-buffer-size <value>
 
    Set read buffer size using ``setvbuf`` to speed up pcap reading. Valid values
-   are 4 KiB to 64 MiB. Default value is 128 KiB. Supported on Linux only.
+   are 0, which disables ``setvbuf`` buffering, or 4 KiB to 64 MiB. Default
+   value is 128 KiB. Supported on Linux only.
 
 .. option::  -i <interface>
 
diff --git a/src/source-pcap-file-helper.c b/src/source-pcap-file-helper.c
index e88db6d51547..70cb2f550bb5 100644
--- a/src/source-pcap-file-helper.c
+++ b/src/source-pcap-file-helper.c
@@ -271,10 +271,16 @@ TmEcode InitPcapFile(PcapFileFileVars *pfv)
 
 #if defined(HAVE_SETVBUF) && defined(OS_LINUX)
     if (pcap_g.read_buffer_size > 0) {
-        errno = 0;
-        if (setvbuf(pcap_file(pfv->pcap_handle), pfv->buffer, _IOFBF, pcap_g.read_buffer_size) <
-                0) {
-            SCLogWarning("Failed to setvbuf on PCAP file handle: %s", strerror(errno));
+        struct stat sb;
+        int fd = fileno(pcap_file(pfv->pcap_handle));
+        if (fd >= 0 && fstat(fd, &sb) == 0 && !S_ISREG(sb.st_mode)) {
+            SCLogInfo("%s: skipping setvbuf, underlying fd is not a regular file", pfv->filename);
+        } else {
+            errno = 0;
+            if (setvbuf(pcap_file(pfv->pcap_handle), pfv->buffer, _IOFBF,
+                        pcap_g.read_buffer_size) != 0) {
+                SCLogWarning("Failed to setvbuf on PCAP file handle: %s", strerror(errno));
+            }
         }
     }
 #endif
diff --git a/src/source-pcap-file.c b/src/source-pcap-file.c
index 808fe27b69cb..b32a0cecea59 100644
--- a/src/source-pcap-file.c
+++ b/src/source-pcap-file.c
@@ -158,13 +158,19 @@ void PcapFileGlobalInit(void)
     if (SCConfGet("pcap-file.buffer-size", &str) == 1) {
         uint32_t value = 0;
         if (ParseSizeStringU32(str, &value) < 0) {
-            SCLogWarning("failed to parse pcap-file.buffer-size %s", str);
-        }
-        if (value >= PCAP_FILE_BUFFER_SIZE_MIN && value <= PCAP_FILE_BUFFER_SIZE_MAX) {
-            SCLogInfo("Pcap-file will use %u buffer size", value);
+            SCLogWarning("failed to parse pcap-file.buffer-size %s; keeping default %u", str,
+                    PCAP_FILE_BUFFER_SIZE_DEFAULT);
+        } else if (value == 0 ||
+                   (value >= PCAP_FILE_BUFFER_SIZE_MIN && value <= PCAP_FILE_BUFFER_SIZE_MAX)) {
+            if (value == 0) {
+                SCLogInfo("Pcap-file buffering disabled");
+            } else {
+                SCLogInfo("Pcap-file will use %u buffer size", value);
+            }
             pcap_g.read_buffer_size = value;
         } else {
-            SCLogWarning("pcap-file.buffer-size value of %u is invalid. Valid range is %u-%u",
+            SCLogWarning("pcap-file.buffer-size value of %u is invalid. Valid values are 0 to "
+                         "disable buffering, or %u-%u",
                     value, PCAP_FILE_BUFFER_SIZE_MIN, PCAP_FILE_BUFFER_SIZE_MAX);
         }
     }