Erythromycin-Carbamazepine-DDI.json

{
  "Version": 79,
  "ExpressionProfiles": [
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "Barzaghi1987",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "OATP1B1",
      "Category": "Barzaghi1987",
      "Parameters": [
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        }
      ],
      "TransportType": "Influx",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainPlasmaToInterstitial",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainInterstitialToTissue",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "InfluxPlasmaToBloodCells"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "InfluxPlasmaToInterstitial"
        }
      ]
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP2B6",
      "Category": "Barzaghi1987",
      "Parameters": [
        {
          "Path": "CYP2B6|Reference concentration",
          "Value": 1.56,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP2B6|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP2B6|t1/2 (liver)",
          "Value": 32.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0021211129296
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0063502454992
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP2B6|Relative expression",
          "Value": 0.1043535188
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP2B6|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP2B6|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP2B6|Relative expression",
          "Value": 0.5970540098
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT2B7",
      "Category": "Barzaghi1987",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression",
          "Value": 0.00094468085106
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Pancreas|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0354468085
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "UGT2B7|Reference concentration",
          "Value": 3.372,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "Ohtsuki et al. 2011"
          }
        },
        {
          "Path": "UGT2B7|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT2B7|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "UGT2B7"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "Wong1983",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "OATP1B1",
      "Category": "Wong1983",
      "Parameters": [
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        }
      ],
      "TransportType": "Influx",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainPlasmaToInterstitial",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainInterstitialToTissue",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "InfluxPlasmaToBloodCells"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "InfluxPlasmaToInterstitial"
        }
      ]
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP2B6",
      "Category": "Wong1983",
      "Parameters": [
        {
          "Path": "CYP2B6|Reference concentration",
          "Value": 1.56,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP2B6|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP2B6|t1/2 (liver)",
          "Value": 32.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0021211129296
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0063502454992
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP2B6|Relative expression",
          "Value": 0.1043535188
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP2B6|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP2B6|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP2B6|Relative expression",
          "Value": 0.5970540098
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT2B7",
      "Category": "Wong1983",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression",
          "Value": 0.00094468085106
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Pancreas|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0354468085
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "UGT2B7|Reference concentration",
          "Value": 3.372,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "UGT2B7|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT2B7|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Localization": "Intracellular",
      "Ontogeny": {
        "Name": "UGT2B7"
      }
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP3A4",
      "Category": "Miles1989",
      "Parameters": [
        {
          "Path": "CYP3A4|Reference concentration",
          "Value": 4.32,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP3A4|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP3A4|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0041682898325
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00078691079081
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0053603428126
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP3A4|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP3A4|Relative expression",
          "Value": 0.00042695753798
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP3A4|Relative expression",
          "Value": 0.0727697702
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome",
      "Ontogeny": {
        "Name": "CYP3A4"
      }
    },
    {
      "Type": "Transporter",
      "Species": "Human",
      "Molecule": "OATP1B1",
      "Category": "Miles1989",
      "Parameters": [
        {
          "Path": "OATP1B1|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "OATP1B1|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "OATP1B1|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00014166666667
        },
        {
          "Path": "Organism|Gonads|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0141666667
        },
        {
          "Path": "Organism|Heart|Intracellular|OATP1B1|Relative expression",
          "Value": 0.0008253968254
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|OATP1B1|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|OATP1B1|Relative expression",
          "Value": 4.0079365079E-05
        },
        {
          "Path": "Organism|Muscle|Intracellular|OATP1B1|Relative expression",
          "Value": 0.00064682539683
        }
      ],
      "TransportType": "Influx",
      "Expression": [
        {
          "Name": "Bone",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainPlasmaToInterstitial",
          "CompartmentName": "Plasma"
        },
        {
          "Name": "Brain",
          "TransportDirection": "InfluxBrainInterstitialToTissue",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Fat",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Gonads",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Heart",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Kidney",
          "TransportDirection": "ExcretionKidney",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Stomach",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "SmallIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Duodenum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerJejunum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "UpperIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "LowerIleum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "LargeIntestine",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Caecum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonAscendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonTransversum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonDescendens",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "ColonSigmoid",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Rectum",
          "TransportDirection": "InfluxLumenToMucosaIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Periportal",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Interstitial"
        },
        {
          "Name": "Pericentral",
          "TransportDirection": "ExcretionLiver",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Lung",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Muscle",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Pancreas",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Skin",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "Spleen",
          "TransportDirection": "InfluxInterstitialToIntracellular",
          "CompartmentName": "Intracellular"
        },
        {
          "Name": "BloodCells",
          "TransportDirection": "InfluxPlasmaToBloodCells"
        },
        {
          "Name": "VascularEndothelium",
          "TransportDirection": "InfluxPlasmaToInterstitial"
        }
      ]
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "CYP2B6",
      "Category": "Miles1989",
      "Parameters": [
        {
          "Path": "CYP2B6|Reference concentration",
          "Value": 1.56,
          "Unit": "µmol/l"
        },
        {
          "Path": "CYP2B6|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "CYP2B6|t1/2 (liver)",
          "Value": 32.0,
          "Unit": "h"
        },
        {
          "Path": "Organism|Brain|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0021211129296
        },
        {
          "Path": "Organism|Gonads|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0063502454992
        },
        {
          "Path": "Organism|Kidney|Intracellular|CYP2B6|Relative expression",
          "Value": 0.1043535188
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|CYP2B6|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|CYP2B6|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Lung|Intracellular|CYP2B6|Relative expression",
          "Value": 0.5970540098
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CYP2B6|Relative expression",
          "Value": 0.0703109656
        }
      ],
      "Localization": "Intracellular, BloodCellsIntracellular, VascEndosome"
    },
    {
      "Type": "Enzyme",
      "Species": "Human",
      "Molecule": "UGT2B7",
      "Category": "Miles1989",
      "Parameters": [
        {
          "Path": "Organism|Gonads|Intracellular|UGT2B7|Relative expression",
          "Value": 0.00094468085106
        },
        {
          "Path": "Organism|LargeIntestine|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0049787234043
        },
        {
          "Path": "Organism|Liver|Pericentral|Intracellular|UGT2B7|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Liver|Periportal|Intracellular|UGT2B7|Relative expression",
          "Value": 1.0
        },
        {
          "Path": "Organism|Pancreas|Intracellular|UGT2B7|Relative expression",
          "Value": 0.0354468085
        },
        {
          "Path": "Organism|SmallIntestine|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|UGT2B7|Relative expression",
          "Value": 0.5361702128
        },
        {
          "Path": "UGT2B7|Reference concentration",
          "Value": 3.372,
          "Unit": "µmol/l",
          "ValueOrigin": {
            "Source": "Unknown"
          }
        },
        {
          "Path": "UGT2B7|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "UGT2B7|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "Localization": "Intracellular",
      "Ontogeny": {
        "Name": "UGT2B7"
      }
    }
  ],
  "Individuals": [
    {
      "Name": "Barzaghi1987",
      "Seed": 1877189984,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "European_ICRP_2002",
        "Gender": "MALE",
        "Age": {
          "Value": 24.0,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 70.0,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "CYP3A4|Human|Barzaghi1987",
        "OATP1B1|Human|Barzaghi1987",
        "CYP2B6|Human|Barzaghi1987",
        "UGT2B7|Human|Barzaghi1987"
      ]
    },
    {
      "Name": "Wong1983",
      "Seed": 1892668203,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "WhiteAmerican_NHANES_1997",
        "Gender": "MALE",
        "Age": {
          "Value": 30.0,
          "Unit": "year(s)"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "CYP3A4|Human|Wong1983",
        "OATP1B1|Human|Wong1983",
        "CYP2B6|Human|Wong1983",
        "UGT2B7|Human|Wong1983"
      ]
    },
    {
      "Name": "Miles1989",
      "Seed": 1741296282,
      "OriginData": {
        "CalculationMethods": [
          "SurfaceAreaPlsInt_VAR1",
          "Body surface area - Mosteller"
        ],
        "Species": "Human",
        "Population": "WhiteAmerican_NHANES_1997",
        "Gender": "MALE",
        "Age": {
          "Value": 25.4,
          "Unit": "year(s)"
        },
        "Weight": {
          "Value": 78.8,
          "Unit": "kg"
        }
      },
      "Parameters": [
        {
          "Path": "Organism|Liver|EHC continuous fraction",
          "Value": 1.0,
          "ValueOrigin": {
            "Source": "Unknown"
          }
        }
      ],
      "ExpressionProfiles": [
        "CYP3A4|Human|Miles1989",
        "OATP1B1|Human|Miles1989",
        "CYP2B6|Human|Miles1989",
        "UGT2B7|Human|Miles1989"
      ]
    }
  ],
  "Compounds": [
    {
      "Name": "Carbamazepine",
      "IsSmallMolecule": true,
      "PlasmaProteinBindingPartner": "Albumin",
      "Lipophilicity": [
        {
          "Name": "Optimized",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.0067753065,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '001-5-3_CYP3A4_MM-kinetics_WithoutTablet' on 2022-02-21 16:49"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Morselli 1975",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.243,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Morselli 1975"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "IR tablet (FaHIF)",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 308.3333,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo",
                "Description": "Mean value of the following FaHIF solubility data reported in the literature: 336 µg/mL, pH 6.2 (Annaert 2010); 283 µg/mL, pH 7.0 (Söderlind 2010); 306 mg/mL, pH 6.9 (Clarysse 2011)"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 6.7,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo",
                "Description": "Mean value of the following FaHIF solubility data reported in the literature: 336 µg/mL, pH 6.2 (Annaert 2010); 283 µg/mL, pH 7.0 (Söderlind 2010); 306 mg/mL, pH 6.9 (Clarysse 2011)"
              }
            }
          ]
        },
        {
          "Name": "XR tablet (fitted)",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 546.0199756643,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '004-2_from-003-1_XRtablet_fasted_solubility_FINAL' on 2022-03-24 12:41"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 6.7,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '004-2_from-003-1_XRtablet_fasted_solubility_FINAL' on 2022-03-16 18:25"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Acid",
          "Pka": 11.83,
          "ValueOrigin": {
            "Source": "Publication",
            "Description": "Tomaszewska 2013"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "Induction",
          "DataSource": "DMPK",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "EC50",
              "Value": 27.193363407,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '003-1_from002-3-6_EC50' on 2022-02-24 10:23"
              }
            },
            {
              "Name": "Emax",
              "Value": 5.3929777775,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "DMPK measurement, calibrated with rifampicin"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "Glomerular Filtration",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 0.0240108793,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '002-3-6_from001-5-3_IRtablet-sd_Pint-FIX_FINAL' on 2022-02-23 17:18"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "N-Glucuronidation_Staines2004",
          "Molecule": "UGT2B7",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 3.5,
              "Unit": "pmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Staines 2004"
              }
            },
            {
              "Name": "Content of CYP proteins in liver microsomes",
              "Value": 82.9,
              "Unit": "pmol/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Achour et al - 2014"
              }
            },
            {
              "Name": "Km",
              "Value": 234.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Staines2004"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.0668699322,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '002-3-6_from001-5-3_IRtablet-sd_Pint-FIX_FINAL' on 2022-02-23 17:18"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "3-Hydroxylation_Pearce2002",
          "Molecule": "CYP2B6",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 49.0,
              "Unit": "pmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Pearce et al. 2002"
              }
            },
            {
              "Name": "Content of CYP proteins in liver microsomes",
              "Value": 39.0,
              "Unit": "pmol/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Rodrigues 1999"
              }
            },
            {
              "Name": "Km",
              "Value": 235.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Unknown",
                "Description": "Pearce 2002"
              }
            },
            {
              "Name": "kcat",
              "Value": 0.9361790504,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '002-3-6_from001-5-3_IRtablet-sd_Pint-FIX_FINAL' on 2022-02-23 17:18"
              }
            }
          ]
        },
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Epoxidation_Sakamoto2013",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 726.0,
              "Unit": "pmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Unknown",
                "Description": "Sakamoto 2013"
              }
            },
            {
              "Name": "Km",
              "Value": 808.0,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "Unknown",
                "Description": "Sakamoto 2013"
              }
            },
            {
              "Name": "kcat",
              "Value": 5.0088763476,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '002-3-6_from001-5-3_IRtablet-sd_Pint-FIX_FINAL' on 2022-02-23 17:18"
              }
            }
          ]
        },
        {
          "InternalName": "Induction",
          "DataSource": "Faucette2004",
          "Molecule": "CYP2B6",
          "Parameters": [
            {
              "Name": "EC50",
              "Value": 1000.0,
              "Unit": "µmol/l"
            },
            {
              "Name": "Emax",
              "Value": 148.7284
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - PK-Sim Standard"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 236.2686,
          "Unit": "g/mol",
          "ValueOrigin": {
            "Source": "Internet",
            "Description": "DrugBank"
          }
        }
      ]
    },
    {
      "Name": "Erythromycin",
      "IsSmallMolecule": true,
      "Lipophilicity": [
        {
          "Name": "Literature (average value)",
          "Parameters": [
            {
              "Name": "Lipophilicity",
              "Value": 2.82,
              "Unit": "Log Units",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            }
          ]
        }
      ],
      "FractionUnbound": [
        {
          "Name": "Barre 1987",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (plasma, reference value)",
              "Value": 0.305,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVivo",
                "Description": "PMID: 3606934"
              }
            }
          ]
        }
      ],
      "Solubility": [
        {
          "Name": "Erythromycin stearate film-coated tablet",
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 28.0708790976,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '003 - BP conc ratio FIX' on 2019-11-14 14:43"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '001' on 2019-10-01 13:46"
              }
            }
          ]
        },
        {
          "Name": "Erythromycin base enteric coated pellets",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 500.0,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '001' on 2019-10-01 13:46"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from '001' on 2019-10-01 13:46"
              }
            }
          ]
        },
        {
          "Name": "Erythromycin lactobionate",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 200.0,
              "Unit": "mg/ml",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Hoffhine, Jr Charles E. \"Aqueous soluble salts of erythromycin.\" U.S. Patent 2,761,859, issued September 4, 1956. "
              }
            },
            {
              "Name": "Reference pH",
              "Value": 7.0,
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Hoffhine, Jr Charles E. \"Aqueous soluble salts of erythromycin.\" U.S. Patent 2,761,859, issued September 4, 1956. "
              }
            }
          ]
        },
        {
          "Name": "Erythromycin base enteric coated tablet",
          "IsDefault": false,
          "Parameters": [
            {
              "Name": "Solubility at reference pH",
              "Value": 8.3990771997,
              "Unit": "mg/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            },
            {
              "Name": "Reference pH",
              "Value": 7.0
            }
          ]
        }
      ],
      "IntestinalPermeability": [
        {
          "Name": "Fitted",
          "Parameters": [
            {
              "Name": "Specific intestinal permeability (transcellular)",
              "Value": 0.00038668371665,
              "Unit": "cm/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            }
          ]
        }
      ],
      "PkaTypes": [
        {
          "Type": "Base",
          "Pka": 8.88,
          "ValueOrigin": {
            "Source": "Publication",
            "Method": "Unknown",
            "Description": "PMID: 9135031"
          }
        }
      ],
      "Processes": [
        {
          "InternalName": "MetabolizationLiverMicrosomes_MM",
          "DataSource": "Biotransformation_fitted",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "In vitro Vmax for liver microsomes",
              "Value": 918.33333,
              "Unit": "pmol/min/mg mic. protein",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 9566442"
              }
            },
            {
              "Name": "Km",
              "Value": 70.0,
              "Unit": "µM",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "Average of reported values in the literature (PMID: 9107550 and PMID: 9566442)"
              }
            }
          ]
        },
        {
          "InternalName": "GlomerularFiltration",
          "DataSource": "fitted",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "GFR fraction",
              "Value": 1.1591081815,
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            }
          ]
        },
        {
          "InternalName": "IrreversibleInhibition",
          "DataSource": "MBI",
          "Molecule": "CYP3A4",
          "Parameters": [
            {
              "Name": "kinact",
              "Value": 0.0296261146,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            },
            {
              "Name": "K_kinact_half",
              "Value": 7.6007360452,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            }
          ]
        },
        {
          "InternalName": "ActiveTransportSpecific_MM",
          "DataSource": "fitted",
          "Molecule": "OATP1B1",
          "Parameters": [
            {
              "Name": "Transporter concentration",
              "Value": 1.0,
              "Unit": "µmol/l"
            },
            {
              "Name": "Vmax",
              "Value": 11.66,
              "Unit": "pmol/ml/min",
              "ValueOrigin": {
                "Source": "Publication",
                "Method": "InVitro",
                "Description": "PMID: 22990751"
              }
            },
            {
              "Name": "Km",
              "Value": 0.735836485,
              "Unit": "µmol/l",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            },
            {
              "Name": "kcat",
              "Value": 1.350032201,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            }
          ]
        },
        {
          "InternalName": "LiverClearance",
          "DataSource": "fitted",
          "Species": "Human",
          "Parameters": [
            {
              "Name": "Fraction unbound (experiment)",
              "Value": 0.305
            },
            {
              "Name": "Lipophilicity (experiment)",
              "Value": 2.48,
              "Unit": "Log Units"
            },
            {
              "Name": "Plasma clearance",
              "Value": 0.0,
              "Unit": "ml/min/kg"
            },
            {
              "Name": "Specific clearance",
              "Value": 4.1462183378,
              "Unit": "1/min",
              "ValueOrigin": {
                "Source": "ParameterIdentification",
                "Method": "ParameterIdentification",
                "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
              }
            }
          ]
        }
      ],
      "CalculationMethods": [
        "Cellular partition coefficient method - Rodgers and Rowland",
        "Cellular permeability - Charge dependent Schmitt"
      ],
      "Parameters": [
        {
          "Name": "Molecular weight",
          "Value": 733.927,
          "Unit": "g/mol",
          "ValueOrigin": {
            "Source": "Internet",
            "Description": "drugbank.ca"
          }
        }
      ]
    }
  ],
  "Formulations": [
    {
      "Name": "CBZ_tabletIR_fasted (Tegretol)",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 109.3089775422,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from '002-3-6_from001-5-3_IRtablet-sd_Pint-FIX_FINAL' on 2022-02-23 17:18"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min"
        },
        {
          "Name": "Dissolution shape",
          "Value": 0.6890123758,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from '002-3-6_from001-5-3_IRtablet-sd_Pint-FIX_FINAL' on 2022-02-23 17:18"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Erythromycin_Weibull_filmtablet",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 1.7038947098,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "Other",
            "Method": "Assumption"
          }
        },
        {
          "Name": "Dissolution shape",
          "Value": 1.0960212213,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Erythromycin_Weibull_filmtablet_250mg",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 83.6562552486,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Lag time",
          "Value": 0.0,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "Other",
            "Method": "Assumption"
          }
        },
        {
          "Name": "Dissolution shape",
          "Value": 3.2811974117,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    },
    {
      "Name": "Erythromycin_Weibull_enteric-coated-pellets",
      "FormulationType": "Formulation_Tablet_Weibull",
      "Parameters": [
        {
          "Name": "Dissolution time (50% dissolved)",
          "Value": 1.7462743767,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Lag time",
          "Value": 54.3490442506,
          "Unit": "min",
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Dissolution shape",
          "Value": 1.0564916105,
          "ValueOrigin": {
            "Source": "ParameterIdentification",
            "Method": "ParameterIdentification",
            "Description": "Value updated from 'Parameter Identification 1' on 2020-01-13 15:01"
          }
        },
        {
          "Name": "Use as suspension",
          "Value": 1.0
        }
      ]
    }
  ],
  "Protocols": [
    {
      "Name": "Barzaghi1987_ControlPhase",
      "ApplicationType": "Oral",
      "DosingInterval": "Single",
      "Parameters": [
        {
          "Name": "Start time",
          "Value": 0.0,
          "Unit": "h"
        },
        {
          "Name": "InputDose",
          "Value": 400.0,
          "Unit": "mg"
        },
        {
          "Name": "Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ]
    },
    {
      "Name": "Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 357.1,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 14.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Barzaghi1987_TreatmentPhase_Carbamazepine",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 400.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 144.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Barzaghi1987_TreatmentPhase_Erythromycin",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 500.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 30.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 8.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Wong1983_TreatmentPhase_Erythromycin",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 250.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 32.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 6.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Wong1983_TreatmentPhase_Carbamazepine",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 400.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 120.0,
              "Unit": "h"
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 1.0
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 0.0,
              "Unit": "h"
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 300mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 300.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 17.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Miles 1989 - TreatmentPhase - Erythromycin",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 250.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 336.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 12.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 6.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 357.1428571429,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 17.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    },
    {
      "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 400mg",
      "DosingInterval": "Single",
      "Schemas": [
        {
          "Name": "Schema 1",
          "SchemaItems": [
            {
              "Name": "Schema Item 1",
              "ApplicationType": "Oral",
              "FormulationKey": "Formulation",
              "Parameters": [
                {
                  "Name": "Start time",
                  "Value": 0.0,
                  "Unit": "h"
                },
                {
                  "Name": "InputDose",
                  "Value": 400.0,
                  "Unit": "mg"
                },
                {
                  "Name": "Volume of water/body weight",
                  "Value": 3.5,
                  "Unit": "ml/kg"
                }
              ]
            }
          ],
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "NumberOfRepetitions",
              "Value": 17.0,
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "TimeBetweenRepetitions",
              "Value": 24.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        }
      ],
      "TimeUnit": "h"
    }
  ],
  "Simulations": [
    {
      "Name": "Barzaghi1987_ControlPhase",
      "Model": "4Comp",
      "ObservedData": [
        "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 96.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Barzaghi1987_ControlPhase|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Barzaghi1987",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Barzaghi1987_ControlPhase",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µmol/l",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Barzaghi1987_ControlPhase-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Barzaghi1987_ControlPhase|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|Time",
              "Y": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 7,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Barzaghi1987_400mg_sd_tabIR_fed",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nBarzaghi1987_ControlPhase\n2022-05-09 10:25"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        }
      ]
    },
    {
      "Name": "Barzaghi1987_TreatmentPhase",
      "Model": "4Comp",
      "ObservedData": [
        "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 8.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 144.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 144.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 146.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 146.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 240.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Carbamazepine|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_18|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_19|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_20|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_21|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_22|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_23|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_24|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_25|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_26|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_27|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_28|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_29|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_30|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Barzaghi1987_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Undefined Liver|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "Undefined Liver|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "Undefined Liver|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
        "Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Barzaghi1987",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Barzaghi1987_TreatmentPhase_Carbamazepine",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        },
        {
          "Name": "Erythromycin",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - Charge dependent Schmitt"
          ],
          "Alternatives": [
            {
              "AlternativeName": "Erythromycin stearate film-coated tablet",
              "GroupName": "COMPOUND_SOLUBILITY"
            },
            {
              "AlternativeName": "Fitted",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Biotransformation_fitted",
              "MoleculeName": "CYP3A4"
            },
            {
              "MoleculeName": "CYP2B6"
            },
            {
              "MoleculeName": "UGT2B7"
            },
            {
              "Name": "Total Hepatic Clearance-fitted",
              "SystemicProcessType": "Hepatic"
            },
            {
              "Name": "OATP1B1-fitted",
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-fitted",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Barzaghi1987_TreatmentPhase_Erythromycin",
            "Formulations": [
              {
                "Name": "Erythromycin_Weibull_filmtablet",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µmol/l",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Barzaghi1987_TreatmentPhase-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Barzaghi1987_TreatmentPhase|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|Time",
              "Y": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 3,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            },
            {
              "Name": "Erythromycin-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Barzaghi1987_TreatmentPhase|Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 2
              }
            }
          ],
          "Name": "Barzaghi1987_400mg_sd_tabIR_fed",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nBarzaghi1987_TreatmentPhase\n2022-05-09 10:28"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP3A4-MBI",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Erythromycin"
        }
      ]
    },
    {
      "Name": "Miles1989_ControlPhase_300mg",
      "Model": "4Comp",
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 408.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Miles1989",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 300mg",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Miles1989_ControlPhase_300mg-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_ControlPhase_300mg|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            }
          ],
          "Name": "Miles1989_control_357_md_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nMiles1989_ControlPhase_300mg\n2022-05-09 10:32"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        }
      ]
    },
    {
      "Name": "Miles1989_ControlPhase_357mg",
      "Model": "4Comp",
      "ObservedData": [
        "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 336.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid|CBZ_tabletIR_fasted (Tegretol)|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Miles1989",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - ControlPhase - Carbamazepine 357.1 mg bid",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "Min": 309.0656,
              "Max": 339.8996,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "Min": 4.742403,
              "Max": 8.0,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Miles1989_ControlPhase_357mg-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_ControlPhase_357mg|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|Time",
              "Y": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 3,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Miles1989_control_357_md_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nMiles1989_ControlPhase_357mg\n2022-05-09 10:37"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        }
      ]
    },
    {
      "Name": "Miles1989_ControlPhase_400mg",
      "Model": "4Comp",
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 408.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Miles1989",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 400mg",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Miles1989_ControlPhase_400mg-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_ControlPhase_400mg|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            }
          ],
          "Name": "Miles1989_control_357_md_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nMiles1989_ControlPhase_400mg\n2022-05-09 10:40"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        }
      ]
    },
    {
      "Name": "Miles1989_TreatmentPhase_300mg",
      "Model": "4Comp",
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 408.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 300mg|CBZ_tabletIR_fasted (Tegretol)|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Undefined Liver|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "Undefined Liver|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "Undefined Liver|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
        "Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Miles1989",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 300mg",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        },
        {
          "Name": "Erythromycin",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - Charge dependent Schmitt"
          ],
          "Alternatives": [
            {
              "AlternativeName": "Erythromycin base enteric coated pellets",
              "GroupName": "COMPOUND_SOLUBILITY"
            },
            {
              "AlternativeName": "Fitted",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Biotransformation_fitted",
              "MoleculeName": "CYP3A4"
            },
            {
              "MoleculeName": "CYP2B6"
            },
            {
              "MoleculeName": "UGT2B7"
            },
            {
              "Name": "Total Hepatic Clearance-fitted",
              "SystemicProcessType": "Hepatic"
            },
            {
              "Name": "OATP1B1-fitted",
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-fitted",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Erythromycin",
            "Formulations": [
              {
                "Name": "Erythromycin_Weibull_enteric-coated-pellets",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Miles1989_TreatmentPhase_300mg-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_TreatmentPhase_300mg|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Erythromycin-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_TreatmentPhase_300mg|Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 2
              }
            }
          ],
          "Name": "Miles1989_control_357_md_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nMiles1989_TreatmentPhase_300mg\n2022-05-04 10:04"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP3A4-MBI",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Erythromycin"
        }
      ]
    },
    {
      "Name": "Miles1989_TreatmentPhase_357mg",
      "Model": "4Comp",
      "ObservedData": [
        "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)"
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 408.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg|CBZ_tabletIR_fasted (Tegretol)|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Undefined Liver|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "Undefined Liver|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "Undefined Liver|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
        "Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Miles1989",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 357.1mg",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        },
        {
          "Name": "Erythromycin",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - Charge dependent Schmitt"
          ],
          "Alternatives": [
            {
              "AlternativeName": "Erythromycin base enteric coated pellets",
              "GroupName": "COMPOUND_SOLUBILITY"
            },
            {
              "AlternativeName": "Fitted",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Biotransformation_fitted",
              "MoleculeName": "CYP3A4"
            },
            {
              "MoleculeName": "CYP2B6"
            },
            {
              "MoleculeName": "UGT2B7"
            },
            {
              "Name": "Total Hepatic Clearance-fitted",
              "SystemicProcessType": "Hepatic"
            },
            {
              "Name": "OATP1B1-fitted",
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-fitted",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Erythromycin",
            "Formulations": [
              {
                "Name": "Erythromycin_Weibull_enteric-coated-pellets",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Miles1989_TreatmentPhase_357mg-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_TreatmentPhase_357mg|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Erythromycin-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_TreatmentPhase_357mg|Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 2
              }
            },
            {
              "Name": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|Time",
              "Y": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 3,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Miles1989_control_357_md_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nMiles1989_TreatmentPhase_357mg\n2022-05-09 10:47"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP3A4-MBI",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Erythromycin"
        }
      ]
    },
    {
      "Name": "Miles1989_TreatmentPhase_400mg",
      "Model": "4Comp",
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 10.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 384.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 386.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 408.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Carbamazepine 400mg|CBZ_tabletIR_fasted (Tegretol)|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Miles 1989 - TreatmentPhase - Erythromycin|Erythromycin_Weibull_enteric-coated-pellets|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Undefined Liver|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "Undefined Liver|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "Undefined Liver|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
        "Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Miles1989",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Carbamazepine 400mg",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        },
        {
          "Name": "Erythromycin",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - Charge dependent Schmitt"
          ],
          "Alternatives": [
            {
              "AlternativeName": "Erythromycin base enteric coated pellets",
              "GroupName": "COMPOUND_SOLUBILITY"
            },
            {
              "AlternativeName": "Fitted",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Biotransformation_fitted",
              "MoleculeName": "CYP3A4"
            },
            {
              "MoleculeName": "CYP2B6"
            },
            {
              "MoleculeName": "UGT2B7"
            },
            {
              "Name": "Total Hepatic Clearance-fitted",
              "SystemicProcessType": "Hepatic"
            },
            {
              "Name": "OATP1B1-fitted",
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-fitted",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Miles 1989 - TreatmentPhase - Erythromycin",
            "Formulations": [
              {
                "Name": "Erythromycin_Weibull_enteric-coated-pellets",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Miles1989_TreatmentPhase_400mg-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_TreatmentPhase_400mg|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Erythromycin-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Miles1989_TreatmentPhase_400mg|Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 2
              }
            }
          ],
          "Name": "Miles1989_control_357_md_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nMiles1989_TreatmentPhase_400mg\n2022-05-09 15:42"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP3A4-MBI",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Erythromycin"
        }
      ]
    },
    {
      "Name": "Wong1983_ControlPhase",
      "Model": "4Comp",
      "ObservedData": [
        "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv."
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 72.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Barzaghi1987_ControlPhase|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Wong1983",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Barzaghi1987_ControlPhase",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Wong1983_ControlPhase-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Wong1983_ControlPhase|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|Time",
              "Y": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 6,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Wong1983_control_400mg_sd_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nWong1983_ControlPhase\n2022-05-09 17:04"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        }
      ]
    },
    {
      "Name": "Wong1983_TreatmentPhase",
      "Model": "4Comp",
      "ObservedData": [
        "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv."
      ],
      "Solver": {},
      "OutputSchema": [
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 0.0,
              "Unit": "h"
            },
            {
              "Name": "End time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 8.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 2.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 120.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 120.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 122.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 20.0,
              "Unit": "pts/h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            }
          ]
        },
        {
          "Parameters": [
            {
              "Name": "Start time",
              "Value": 122.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "End time",
              "Value": 192.0,
              "Unit": "h",
              "ValueOrigin": {
                "Source": "Unknown"
              }
            },
            {
              "Name": "Resolution",
              "Value": 4.0,
              "Unit": "pts/h"
            }
          ]
        }
      ],
      "Parameters": [
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Carbamazepine|CBZ_tabletIR_fasted (Tegretol)|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_1|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_10|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_11|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_12|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_13|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_14|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_15|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_16|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_17|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_18|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_19|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_2|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_20|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_21|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_22|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_23|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_24|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_25|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_26|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_27|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_28|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_29|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_3|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_30|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_31|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_32|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_4|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_5|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_6|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_7|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_8|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Applications|Wong1983_TreatmentPhase_Erythromycin|Erythromycin_Weibull_filmtablet_250mg|Application_9|ProtocolSchemaItem|Volume of water/body weight",
          "Value": 3.5,
          "Unit": "ml/kg"
        },
        {
          "Path": "Undefined Liver|Reference concentration",
          "Value": 1.0,
          "Unit": "µmol/l"
        },
        {
          "Path": "Undefined Liver|t1/2 (intestine)",
          "Value": 23.0,
          "Unit": "h"
        },
        {
          "Path": "Undefined Liver|t1/2 (liver)",
          "Value": 36.0,
          "Unit": "h"
        }
      ],
      "OutputSelections": [
        "Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
        "Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)"
      ],
      "Individual": "Wong1983",
      "Compounds": [
        {
          "Name": "Carbamazepine",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - PK-Sim Standard"
          ],
          "Alternatives": [
            {
              "AlternativeName": "IR tablet (FaHIF)",
              "GroupName": "COMPOUND_SOLUBILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Epoxidation_Sakamoto2013",
              "MoleculeName": "CYP3A4"
            },
            {
              "Name": "CYP2B6-3-Hydroxylation_Pearce2002",
              "MoleculeName": "CYP2B6"
            },
            {
              "Name": "UGT2B7-N-Glucuronidation_Staines2004",
              "MoleculeName": "UGT2B7"
            },
            {
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-Glomerular Filtration",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Wong1983_TreatmentPhase_Carbamazepine",
            "Formulations": [
              {
                "Name": "CBZ_tabletIR_fasted (Tegretol)",
                "Key": "Formulation"
              }
            ]
          }
        },
        {
          "Name": "Erythromycin",
          "CalculationMethods": [
            "Cellular partition coefficient method - Rodgers and Rowland",
            "Cellular permeability - Charge dependent Schmitt"
          ],
          "Alternatives": [
            {
              "AlternativeName": "Erythromycin stearate film-coated tablet",
              "GroupName": "COMPOUND_SOLUBILITY"
            },
            {
              "AlternativeName": "Fitted",
              "GroupName": "COMPOUND_INTESTINAL_PERMEABILITY"
            }
          ],
          "Processes": [
            {
              "Name": "CYP3A4-Biotransformation_fitted",
              "MoleculeName": "CYP3A4"
            },
            {
              "MoleculeName": "CYP2B6"
            },
            {
              "MoleculeName": "UGT2B7"
            },
            {
              "Name": "Total Hepatic Clearance-fitted",
              "SystemicProcessType": "Hepatic"
            },
            {
              "Name": "OATP1B1-fitted",
              "MoleculeName": "OATP1B1"
            },
            {
              "Name": "Glomerular Filtration-fitted",
              "SystemicProcessType": "GFR"
            }
          ],
          "Protocol": {
            "Name": "Wong1983_TreatmentPhase_Erythromycin",
            "Formulations": [
              {
                "Name": "Erythromycin_Weibull_filmtablet_250mg",
                "Key": "Formulation"
              }
            ]
          }
        }
      ],
      "HasResults": true,
      "IndividualAnalyses": [
        {
          "Axes": [
            {
              "Unit": "h",
              "Dimension": "Time",
              "Type": "X",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "None",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            },
            {
              "Unit": "µg/ml",
              "Dimension": "Concentration (molar)",
              "Type": "Y",
              "GridLines": false,
              "Visible": true,
              "DefaultColor": "#FFFFFF",
              "DefaultLineStyle": "Solid",
              "Scaling": "Linear",
              "NumberMode": "Normal"
            }
          ],
          "Curves": [
            {
              "Name": "Wong1983_TreatmentPhase-Carbamazepine-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Wong1983_TreatmentPhase|Organism|PeripheralVenousBlood|Carbamazepine|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 1
              }
            },
            {
              "Name": "Erythromycin-Peripheral Venous Blood-Plasma-Concentration",
              "X": "Time",
              "Y": "Wong1983_TreatmentPhase|Organism|PeripheralVenousBlood|Erythromycin|Plasma (Peripheral Venous Blood)",
              "CurveOptions": {
                "Color": "#FF0000",
                "LegendIndex": 2
              }
            },
            {
              "Name": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.-Carbamazepine-Peripheral Venous Blood-Plasma-ArithmeticMean",
              "X": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|Time",
              "Y": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean",
              "CurveOptions": {
                "Color": "#0000FF",
                "LegendIndex": 3,
                "LineStyle": "None",
                "Symbol": "Circle"
              }
            }
          ],
          "Name": "Wong1983_control_400mg_sd_tabIR",
          "FontAndSize": {
            "Fonts": {
              "AxisSize": 10,
              "LegendSize": 8,
              "TitleSize": 16,
              "DescriptionSize": 12,
              "OriginSize": 8,
              "FontFamilyName": "Microsoft Sans Serif",
              "WatermarkSize": 32
            }
          },
          "Settings": {
            "SideMarginsEnabled": true,
            "LegendPosition": "RightInside",
            "BackColor": "#00FFFFFF",
            "DiagramBackColor": "#FFFFFF"
          },
          "OriginText": "Erythromycin-Carbamazepine-DDI\nWong1983_TreatmentPhase\n2022-05-09 17:07"
        }
      ],
      "Interactions": [
        {
          "Name": "CYP3A4-DMPK",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP2B6-Faucette2004",
          "MoleculeName": "CYP2B6",
          "CompoundName": "Carbamazepine"
        },
        {
          "Name": "CYP3A4-MBI",
          "MoleculeName": "CYP3A4",
          "CompoundName": "Erythromycin"
        }
      ]
    }
  ],
  "ObservedData": [
    {
      "Name": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 463.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Barzaghi 1987",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/3440106/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 1a",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "Without erythromycin",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "400 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": 0.0,
          "Type": "Double"
        },
        {
          "Name": "Formulation",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fed",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "RelatedColumns": [
            {
              "Name": "Var",
              "QuantityInfo": {
                "Path": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticStdDev"
              },
              "DataInfo": {
                "Origin": "ObservationAuxiliary",
                "AuxiliaryType": "ArithmeticStdDev",
                "MolWeight": 236.269
              },
              "Values": [
                0.6106672,
                0.4555764,
                0.5137358,
                0.5136919,
                0.8045733,
                0.6785192,
                0.6009734,
                0.6204029,
                0.6397463,
                0.5428153
              ],
              "Dimension": "Concentration (mass)",
              "Unit": "mg/l"
            }
          ],
          "QuantityInfo": {
            "Path": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 236.269
          },
          "Values": [
            3.693691,
            4.94454,
            5.119713,
            4.801061,
            4.000761,
            3.49916,
            2.825349,
            2.459626,
            1.92165112,
            1.308572
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          2.0,
          4.0,
          6.0,
          10.0,
          24.0,
          32.0,
          48.0,
          56.0,
          72.0,
          96.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Barzaghi 1987 - Without erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 464.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Barzaghi 1987",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/3440106/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 1b",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "Without erythromycin",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine-10-11-epoxide",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "400 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": 0.0,
          "Type": "Double"
        },
        {
          "Name": "Formulation",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fed",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "RelatedColumns": [
            {
              "Name": "Var",
              "QuantityInfo": {
                "Path": "Barzaghi 1987 - Without erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|ArithmeticStdDev"
              },
              "DataInfo": {
                "Origin": "ObservationAuxiliary",
                "AuxiliaryType": "ArithmeticStdDev",
                "MolWeight": 252.27
              },
              "Values": [
                0.0152851595,
                0.0178993084,
                0.0301285181,
                0.03055457,
                0.03579338,
                0.03186955,
                0.04409863,
                0.04409866,
                0.02751428,
                0.02270156
              ],
              "Dimension": "Concentration (mass)",
              "Unit": "mg/l"
            }
          ],
          "QuantityInfo": {
            "Path": "Barzaghi 1987 - Without erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 252.27
          },
          "Values": [
            0.03587215,
            0.07349583,
            0.1036873,
            0.1313382,
            0.1763829,
            0.1928195,
            0.158918887,
            0.14829351,
            0.107833795,
            0.07160776
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Barzaghi 1987 - Without erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          2.0,
          4.0,
          6.0,
          10.0,
          24.0,
          32.0,
          48.0,
          56.0,
          72.0,
          96.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 1153.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Wong 1983",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/6831824/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 1",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "Treatment B (without erythromycin)",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "individual",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 8.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "400 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": 0.0,
          "Type": "Double"
        },
        {
          "Name": "Formulation",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "QuantityInfo": {
            "Path": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 236.269
          },
          "Values": [
            2.271022,
            2.394349,
            2.795466,
            3.58727,
            4.063444,
            4.315975,
            4.315197,
            4.169291,
            4.059192,
            3.678204,
            2.864441,
            2.585644,
            2.083754,
            1.777015
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          1.0,
          2.0,
          4.0,
          6.0,
          8.0,
          12.0,
          16.0,
          24.0,
          30.0,
          36.0,
          48.0,
          54.0,
          60.0,
          72.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 1418.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Miles 1989",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/2911854/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 2",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "CBZ before ERY",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "300-400; mean dose: 357.1 +/- 53.5 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": "S0-T24-R14",
          "Type": "String"
        },
        {
          "Name": "Formulation",
          "Value": "200mg tablets - Tegretol, lot no. 1T000470; Ciba-Geigy, Summit, NJ, USA",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fasted",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "QuantityInfo": {
            "Path": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 236.269,
            "LLOQ": 1E-06
          },
          "Values": [
            5.35977,
            6.430851,
            6.982509,
            7.118526,
            7.091334,
            6.885978,
            6.636095,
            6.077072,
            5.503095,
            5.137022
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          312.0,
          314.0,
          316.0,
          318.0,
          320.0,
          322.0,
          324.0,
          328.0,
          332.0,
          336.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Miles 1989 - CBZE before ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 1419.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Miles 1989",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/2911854/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 2",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "CBZE before ERY",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine-10-11-epoxide",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "300-400; mean dose: 357.1 +/- 53.5 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": "S0-T24-R14",
          "Type": "String"
        },
        {
          "Name": "Formulation",
          "Value": "200mg tablets - Tegretol, lot no. 1T000470; Ciba-Geigy, Summit, NJ, USA",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fasted",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "QuantityInfo": {
            "Path": "Miles 1989 - CBZE before ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 252.27,
            "LLOQ": 5E-07
          },
          "Values": [
            1.010919,
            1.072781,
            1.075274,
            1.092552,
            1.139515,
            1.186478,
            1.174128,
            1.13453,
            1.094988,
            1.040547
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Miles 1989 - CBZE before ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          312.0,
          314.0,
          316.0,
          318.0,
          320.0,
          322.0,
          324.0,
          328.0,
          332.0,
          336.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 465.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Barzaghi 1987",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/3440106/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 1a",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "With erythromycin",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "400 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": 144.0,
          "Type": "Double"
        },
        {
          "Name": "Formulation",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fed",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "RelatedColumns": [
            {
              "Name": "Var",
              "QuantityInfo": {
                "Path": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticStdDev"
              },
              "DataInfo": {
                "Origin": "ObservationAuxiliary",
                "AuxiliaryType": "ArithmeticStdDev",
                "MolWeight": 236.269
              },
              "Values": [
                0.5039988,
                0.3684254,
                0.562202,
                0.6591768,
                0.5621142,
                0.5331213,
                0.6009293,
                0.6591327,
                0.6881251,
                0.5912805
              ],
              "Dimension": "Concentration (mass)",
              "Unit": "mg/l"
            }
          ],
          "QuantityInfo": {
            "Path": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 236.269
          },
          "Values": [
            4.313876,
            4.789536,
            4.974317,
            4.762289,
            4.407915,
            3.78991,
            3.406981,
            2.944239,
            2.522624,
            1.812527
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          146.0,
          148.0,
          150.0,
          154.0,
          168.0,
          176.0,
          192.0,
          200.0,
          216.0,
          240.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Barzaghi 1987 - With erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 466.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Barzaghi 1987",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/3440106/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 1b",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "With erythromycin",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine-10-11-epoxide",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "400 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": 144.0,
          "Type": "Double"
        },
        {
          "Name": "Formulation",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fed",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "RelatedColumns": [
            {
              "Name": "Var",
              "QuantityInfo": {
                "Path": "Barzaghi 1987 - With erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|ArithmeticStdDev"
              },
              "DataInfo": {
                "Origin": "ObservationAuxiliary",
                "AuxiliaryType": "ArithmeticStdDev",
                "MolWeight": 252.27
              },
              "Values": [
                0.007858234,
                0.009604511,
                0.008736618,
                0.0117873494,
                0.01877245,
                0.02314342,
                0.0165843386,
                0.01572697,
                0.01571121,
                0.0139754489
              ],
              "Dimension": "Concentration (mass)",
              "Unit": "mg/l"
            }
          ],
          "QuantityInfo": {
            "Path": "Barzaghi 1987 - With erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 252.27
          },
          "Values": [
            0.01709445,
            0.03070686,
            0.0434408672,
            0.05799469,
            0.09954158,
            0.101582006,
            0.1017231,
            0.08630075,
            0.08075599,
            0.06025172
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Barzaghi 1987 - With erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          146.0,
          148.0,
          150.0,
          154.0,
          168.0,
          176.0,
          192.0,
          200.0,
          216.0,
          240.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 1420.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Miles 1989",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/2911854/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 2",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "CBZ during ERY",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "300-400; mean dose: 357.1 +/- 53.5 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": "S0-T24-R17",
          "Type": "String"
        },
        {
          "Name": "Formulation",
          "Value": "200mg tablets - Tegretol, lot no. 1T000470; Ciba-Geigy, Summit, NJ, USA",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fasted",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "QuantityInfo": {
            "Path": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 236.269,
            "LLOQ": 1E-06
          },
          "Values": [
            5.241032,
            6.653486,
            6.982566,
            7.177952,
            7.106176,
            6.796924,
            6.829101,
            6.388704,
            5.85931,
            5.582291
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          384.0,
          386.0,
          388.0,
          390.0,
          392.0,
          394.0,
          396.0,
          400.0,
          404.0,
          408.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Miles 1989 - CBZE during ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 1421.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Miles 1989",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/2911854/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 2",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "CBZE during ERY",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "aggregated",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 7.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine-10-11-epoxide",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "300-400; mean dose: 357.1 +/- 53.5 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": "S0-T24-R17",
          "Type": "String"
        },
        {
          "Name": "Formulation",
          "Value": "200mg tablets - Tegretol, lot no. 1T000470; Ciba-Geigy, Summit, NJ, USA",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": "fasted",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "QuantityInfo": {
            "Path": "Miles 1989 - CBZE during ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine-10-11-epoxide|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 252.27,
            "LLOQ": 5E-07
          },
          "Values": [
            0.8328117,
            0.8501466,
            0.8674815,
            0.8550751,
            0.8575111,
            0.859947,
            0.8772819,
            0.8525259,
            0.8426688,
            0.8178561
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Miles 1989 - CBZE during ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          384.0,
          386.0,
          388.0,
          390.0,
          392.0,
          394.0,
          396.0,
          400.0,
          404.0,
          408.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    },
    {
      "Name": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.",
      "ExtendedProperties": [
        {
          "Name": "DB Version",
          "Value": "OSP DATABASE",
          "Type": "String"
        },
        {
          "Name": "ID",
          "Value": 1154.0,
          "Type": "Double"
        },
        {
          "Name": "Study Id",
          "Value": "Wong 1983",
          "Type": "String"
        },
        {
          "Name": "Reference",
          "Value": "https://pubmed.ncbi.nlm.nih.gov/6831824/",
          "Type": "String"
        },
        {
          "Name": "Source",
          "Value": "Fig. 1",
          "Type": "String"
        },
        {
          "Name": "Grouping",
          "Value": "Treatment A (with erythromycin)",
          "Type": "String"
        },
        {
          "Name": "Data type",
          "Value": "individual",
          "Type": "String"
        },
        {
          "Name": "N",
          "Value": 8.0,
          "Type": "Double"
        },
        {
          "Name": "Molecule",
          "Value": "Carbamazepine",
          "Type": "String"
        },
        {
          "Name": "Species",
          "Value": "Human",
          "Type": "String"
        },
        {
          "Name": "Organ",
          "Value": "Peripheral Venous Blood",
          "Type": "String"
        },
        {
          "Name": "Compartment",
          "Value": "Plasma",
          "Type": "String"
        },
        {
          "Name": "Route",
          "Value": "PO",
          "Type": "String"
        },
        {
          "Name": "Dose",
          "Value": "400 mg",
          "Type": "String"
        },
        {
          "Name": "Times of Administration [h]",
          "Value": 120.0,
          "Type": "Double"
        },
        {
          "Name": "Formulation",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Food state",
          "Value": ".",
          "Type": "String"
        },
        {
          "Name": "Comment",
          "Value": ".",
          "Type": "String"
        }
      ],
      "Columns": [
        {
          "Name": "Avg",
          "QuantityInfo": {
            "Path": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|ObservedData|Peripheral Venous Blood|Plasma|Carbamazepine|ArithmeticMean"
          },
          "DataInfo": {
            "Origin": "Observation",
            "AuxiliaryType": "Undefined",
            "MolWeight": 236.269
          },
          "Values": [
            2.035254,
            2.572669,
            3.301302,
            3.89834571,
            4.834243,
            4.724909,
            4.075684,
            4.704001,
            4.246293,
            3.486601,
            3.171208,
            3.018359,
            2.52562
          ],
          "Dimension": "Concentration (mass)",
          "Unit": "mg/l"
        }
      ],
      "BaseGrid": {
        "Name": "Time",
        "QuantityInfo": {
          "Path": "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.|Time",
          "Type": "Time"
        },
        "DataInfo": {
          "Origin": "BaseGrid",
          "AuxiliaryType": "Undefined"
        },
        "Values": [
          121.0,
          122.0,
          124.0,
          126.0,
          132.0,
          136.0,
          144.0,
          150.0,
          156.0,
          168.0,
          174.0,
          180.0,
          192.0
        ],
        "Dimension": "Time",
        "Unit": "h"
      }
    }
  ],
  "ObservedDataClassifications": [
    {
      "Name": "Wong 1983",
      "Classifiables": [
        "Wong 1983 - Treatment B (without erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv.",
        "Wong 1983 - Treatment A (with erythromycin) - Carbamazepine - PO - 400 mg - Plasma - indiv."
      ]
    },
    {
      "Name": "Miles 1989",
      "Classifiables": [
        "Miles 1989 - CBZ before ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
        "Miles 1989 - CBZE before ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
        "Miles 1989 - CBZ during ERY - Carbamazepine - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)",
        "Miles 1989 - CBZE during ERY - Carbamazepine-10-11-epoxide - PO - 300-400; mean dose: 357.1 +/- 53.5 mg - Serum - agg. (n=7)"
      ]
    },
    {
      "Name": "Barzaghi 1987",
      "Classifiables": [
        "Barzaghi 1987 - Without erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)",
        "Barzaghi 1987 - Without erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)",
        "Barzaghi 1987 - With erythromycin - Carbamazepine - PO - 400 mg - Serum - agg. (n=7)",
        "Barzaghi 1987 - With erythromycin - Carbamazepine-10-11-epoxide - PO - 400 mg - Serum - agg. (n=7)"
      ]
    }
  ]
}