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PV BB: "Add Protein expression" - wrong entries are added? #2307

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PavelBal opened this issue Aug 2, 2024 · 2 comments
Open

PV BB: "Add Protein expression" - wrong entries are added? #2307

PavelBal opened this issue Aug 2, 2024 · 2 comments
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@PavelBal
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PavelBal commented Aug 2, 2024

The user can select organ(s) and molecules for which to add the expression profiles. Are the values taken from an existing expression profile (if so - from which)? If not - should the values be 0 by default (seems like they are)?

If I do this for CYP3A4 and "Liver" as organ, I get the following entries:

image

If I filter for "Liver" in the expression profile of CYP3A4, I see the following parameters:

image

  • Relative expression in vascular endothelium, Relative expression in plasma, and Relative expression in blood cells should not be there
  • Initial concentration, Fraction expressed interstitial, Fraction expressed intracellular are missing
@rwmcintosh
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The created PV are based on the parameters of the molecule. By name we determine if this is an 'Expression'. We currently used this definition for Global relative expression

And of course REL_EXP.

         public static readonly IReadOnlyList<string> AllGlobalRelExpParameters = new[]
         {
            REL_EXP_BLOOD_CELLS,
            REL_EXP_PLASMA,
            REL_EXP_VASCULAR_ENDOTHELIUM,
         };

I can shift the names easily enough.

@rwmcintosh rwmcintosh self-assigned this Aug 22, 2024
@rwmcintosh rwmcintosh added this to the Version 12 milestone Aug 22, 2024
@rwmcintosh rwmcintosh transferred this issue from Open-Systems-Pharmacology/MoBi Aug 22, 2024
@rwmcintosh
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I'm not sure how to handle determining what parameters from a molecule are 'Expression' parameters. We are currently using a list of 4 parameter names to make the determination.

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