Fluoroalkene Isostere
Jo Ubels suggested a fluoroalkene isostere for the amide series. Jo pursued a simplified version of this chemistry with a pyridine ring in place of the pyrazine. The boronic ester (rather than the acids, which were predicted and found to be unstable, GHI250) was synthesized along with the bromofluoroalkene, but the coupling of these fragments has not yet been well explored. (Link to Ubels Honours thesis coming). Most recent experiment in this series.
