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Copy file name to clipboardExpand all lines: docs/annotations.md
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```
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Here `CADD_RAW` is the name of the column of the VEP output when the plugin is used, it is then renamed in the final annotation dataframe to `CADD_raw`, all `NA` values are set to `0` and the values are of type`float`.
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Here `CADD_RAW` is the name of the column of the VEP output when the plugin is used, it is then renamed in the final annotation data frame to `CADD_raw`, all `NA` values are set to `0` and the values are of type`float`.
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You can also modify the `example/config/annotation_colnames_filling_values.yaml` file to choose custom filling values for each of the annotations.
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For each of the annotations the second value represents the value to use to fill in`NA` values, i.e. in the example above, in the `CADD_raw` column `NA` values are filled using `0`.
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```
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to the [config file](https://github.com/PMBio/deeprvat/blob/main/example/config/deeprvat_annotation_config.yaml).
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You can also change the way the allele frequencies are calculated by adding `af_mode` key to the [config file](https://github.com/PMBio/deeprvat/blob/main/example/config/deeprvat_annotation_config.yaml). By default, the allele frequencies are calculated from the data the annotation pipeline is run with. To use gnomade or gnomadg allele frequncies (from VEP ) instead, add
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You can also change the way the allele frequencies are calculated by adding `af_mode` key to the [config file](https://github.com/PMBio/deeprvat/blob/main/example/config/deeprvat_annotation_config.yaml). By default, the allele frequencies are calculated from the data the annotation pipeline is run with. To use gnomade or gnomadg allele frequencies (from VEP ) instead, add
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```shell
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af_mode :'af_gnomade'
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```
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(geneid)=
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## Gene id file
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as mentioned in the [requirements](#requirements) section, the pipeline expects a parquet file contiaining all genes that deeprvat should consider, together with a unique integer id for each gene.
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As mentioned in the [requirements](#requirements) section, the pipeline expects a parquet file containing all genes that deeprvat should consider, together with a unique integer id for each gene.
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This file can be created automatically using a GTF file as input. The output is then a parquet file in the expected format containing all protein coding genes of the provided GTF file.
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To automatically create the gene id file, make sure the annotation environment (mentioned [here](#running) ) is active and run
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