Hugo_to_ENS.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "id": "614d31df",
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import numpy as np\n",
    "import itertools\n",
    "from sklearn import preprocessing"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "ad84d0bb",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>10</th>\n",
       "      <th>...</th>\n",
       "      <th>37</th>\n",
       "      <th>38</th>\n",
       "      <th>39</th>\n",
       "      <th>40</th>\n",
       "      <th>41</th>\n",
       "      <th>42</th>\n",
       "      <th>43</th>\n",
       "      <th>44</th>\n",
       "      <th>45</th>\n",
       "      <th>46</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>Androgen_receptor_signaling_pathway</th>\n",
       "      <td>AR</td>\n",
       "      <td>KLK3</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Cytokine-Jak-STAT_signaling_pathway</th>\n",
       "      <td>IL2</td>\n",
       "      <td>IL3</td>\n",
       "      <td>IL4</td>\n",
       "      <td>IL5</td>\n",
       "      <td>IL6</td>\n",
       "      <td>IL7</td>\n",
       "      <td>IL12A</td>\n",
       "      <td>IL12B</td>\n",
       "      <td>IL13</td>\n",
       "      <td>IL15</td>\n",
       "      <td>...</td>\n",
       "      <td>JAK3</td>\n",
       "      <td>STAT1</td>\n",
       "      <td>STAT2</td>\n",
       "      <td>STAT3</td>\n",
       "      <td>STAT4</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>STAT6</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DCC-apoptotic_pathway</th>\n",
       "      <td>CASP3</td>\n",
       "      <td>DCC</td>\n",
       "      <td>CASP9</td>\n",
       "      <td>APPL1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-PI3K_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-PLCG-CAMK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>CALM1</td>\n",
       "      <td>CALM2</td>\n",
       "      <td>CALM3</td>\n",
       "      <td>CAMK1</td>\n",
       "      <td>CAMK1D</td>\n",
       "      <td>CAMK1G</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-RalGDS_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>RALGDS</td>\n",
       "      <td>RALA</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-RASSF1_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>RASSF1</td>\n",
       "      <td>RASSF5</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-ERBB2-RAS-ERK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>ERBB2</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-Jak-STAT_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>JAK1</td>\n",
       "      <td>STAT1</td>\n",
       "      <td>STAT3</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGF-FGFR-PI3K_signaling_pathway</th>\n",
       "      <td>FGF1</td>\n",
       "      <td>FGF2</td>\n",
       "      <td>FGF3</td>\n",
       "      <td>FGF4</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>FGF6</td>\n",
       "      <td>FGF7</td>\n",
       "      <td>FGF8</td>\n",
       "      <td>FGF9</td>\n",
       "      <td>FGF10</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGF-FGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>FGF1</td>\n",
       "      <td>FGF2</td>\n",
       "      <td>FGF3</td>\n",
       "      <td>FGF4</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>FGF6</td>\n",
       "      <td>FGF7</td>\n",
       "      <td>FGF8</td>\n",
       "      <td>FGF9</td>\n",
       "      <td>FGF10</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-RAS-ERK_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-RAS-PI3K_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-STAT5_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Hedgehog_signaling_pathway</th>\n",
       "      <td>SHH</td>\n",
       "      <td>PTCH1</td>\n",
       "      <td>SMO</td>\n",
       "      <td>SUFU</td>\n",
       "      <td>GLI1</td>\n",
       "      <td>GLI2</td>\n",
       "      <td>GLI3</td>\n",
       "      <td>GLI1</td>\n",
       "      <td>PTCH1</td>\n",
       "      <td>PTCH2</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HGF-MET-PI3K_signaling_pathway</th>\n",
       "      <td>HGF</td>\n",
       "      <td>MET</td>\n",
       "      <td>GAB1</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HGF-MET-RAS-ERK_signaling_pathway</th>\n",
       "      <td>HGF</td>\n",
       "      <td>MET</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HIF-1_signaling_pathway</th>\n",
       "      <td>HIF1A</td>\n",
       "      <td>ARNT</td>\n",
       "      <td>SLC2A1</td>\n",
       "      <td>VEGFA</td>\n",
       "      <td>TGFB1</td>\n",
       "      <td>TGFB2</td>\n",
       "      <td>TGFB3</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>TGFA</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF2-IGF1R-PI3K_signaling_pathway</th>\n",
       "      <td>IGF1</td>\n",
       "      <td>IGF2</td>\n",
       "      <td>IGF1R</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF-IGF1R-RAS-ERK_signaling_pathway</th>\n",
       "      <td>IGF2</td>\n",
       "      <td>IGF1R</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>RPS6KB1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Intrinsic_apoptotic_pathway</th>\n",
       "      <td>PMAIP1</td>\n",
       "      <td>BBC3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>BCL2L11</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>BCL2L1</td>\n",
       "      <td>BAX</td>\n",
       "      <td>BAK1</td>\n",
       "      <td>CYCS</td>\n",
       "      <td>APAF1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KEAP1-NRF2_signaling_pathway</th>\n",
       "      <td>KEAP1</td>\n",
       "      <td>NFE2L2</td>\n",
       "      <td>HMOX1</td>\n",
       "      <td>NQO1</td>\n",
       "      <td>GSTO2</td>\n",
       "      <td>GSTA5</td>\n",
       "      <td>GSTA1</td>\n",
       "      <td>GSTA2</td>\n",
       "      <td>GSTA3</td>\n",
       "      <td>GSTA4</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KITLG-KIT-PI3K_signaling_pathway</th>\n",
       "      <td>KITLG</td>\n",
       "      <td>KIT</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>RPS6KB1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KITLG-KIT-RAS-ERK_signaling_pathway</th>\n",
       "      <td>KITLG</td>\n",
       "      <td>KIT</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MDM2-p21-Cell_cycle_G1-S</th>\n",
       "      <td>CDKN2A</td>\n",
       "      <td>MDM2</td>\n",
       "      <td>TP53</td>\n",
       "      <td>CDKN1A</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NOTCH_signaling_pathway</th>\n",
       "      <td>DLL1</td>\n",
       "      <td>DLL3</td>\n",
       "      <td>DLL4</td>\n",
       "      <td>JAG1</td>\n",
       "      <td>JAG2</td>\n",
       "      <td>NOTCH1</td>\n",
       "      <td>NOTCH2</td>\n",
       "      <td>NOTCH3</td>\n",
       "      <td>NOTCH4</td>\n",
       "      <td>HES1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p15-Cell_cycle_G1-S</th>\n",
       "      <td>MYC</td>\n",
       "      <td>MAX</td>\n",
       "      <td>ZBTB17</td>\n",
       "      <td>CDKN2B</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p16-Cell_cycle_G1-S</th>\n",
       "      <td>CDKN2A</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>E2F1</td>\n",
       "      <td>E2F2</td>\n",
       "      <td>E2F3</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p27-Cell_cycle_G1-S</th>\n",
       "      <td>SKP1</td>\n",
       "      <td>CUL1</td>\n",
       "      <td>RBX1</td>\n",
       "      <td>SKP2</td>\n",
       "      <td>CDKN1B</td>\n",
       "      <td>CCNA2</td>\n",
       "      <td>CCNA1</td>\n",
       "      <td>CCNE1</td>\n",
       "      <td>CCNE2</td>\n",
       "      <td>CDK2</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-PI3K_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-PLCG-CAMK_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>CALM1</td>\n",
       "      <td>CALM2</td>\n",
       "      <td>CALM3</td>\n",
       "      <td>CAMK1</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTEN-PIP3-AKT_signaling_pathway</th>\n",
       "      <td>PTEN</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Telomerase_activity</th>\n",
       "      <td>TERC</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-PI3K_signaling_pathway</th>\n",
       "      <td>TGFB1</td>\n",
       "      <td>TGFB2</td>\n",
       "      <td>TGFB3</td>\n",
       "      <td>TGFBR2</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>SMAD2</td>\n",
       "      <td>SMAD3</td>\n",
       "      <td>SMAD4</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-PLCG-PKC_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>PRKCA</td>\n",
       "      <td>PRKCB</td>\n",
       "      <td>PRKCG</td>\n",
       "      <td>ELK1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGF-beta_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WNT_signaling_pathway</th>\n",
       "      <td>WNT1</td>\n",
       "      <td>WNT2</td>\n",
       "      <td>WNT2B</td>\n",
       "      <td>WNT3</td>\n",
       "      <td>WNT3A</td>\n",
       "      <td>WNT4</td>\n",
       "      <td>WNT5A</td>\n",
       "      <td>WNT5B</td>\n",
       "      <td>WNT6</td>\n",
       "      <td>WNT7A</td>\n",
       "      <td>...</td>\n",
       "      <td>AXIN1</td>\n",
       "      <td>AXIN2</td>\n",
       "      <td>APC</td>\n",
       "      <td>CTNNB1</td>\n",
       "      <td>TCF7</td>\n",
       "      <td>TCF7L1</td>\n",
       "      <td>TCF7L2</td>\n",
       "      <td>LEF1</td>\n",
       "      <td>MYC</td>\n",
       "      <td>CCND1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NaN</th>\n",
       "      <td>\u001a</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>...</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>41 rows × 46 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                            1       2       3        4   \\\n",
       "0                                                                         \n",
       "Androgen_receptor_signaling_pathway         AR    KLK3     NaN      NaN   \n",
       "Cytokine-Jak-STAT_signaling_pathway        IL2     IL3     IL4      IL5   \n",
       "DCC-apoptotic_pathway                    CASP3     DCC   CASP9    APPL1   \n",
       "EGF-EGFR-PI3K_signaling_pathway            EGF    EGFR  PIK3CA   PIK3CB   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway       EGF    EGFR   PLCG1    PLCG2   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway         EGF    EGFR    GRB2     SOS1   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway      EGF    EGFR    GRB2     SOS1   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway      EGF    EGFR    GRB2     SOS1   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway        EGF   ERBB2    EGFR     GRB2   \n",
       "EGF-Jak-STAT_signaling_pathway             EGF    EGFR    JAK1    STAT1   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF1    FGF2    FGF3     FGF4   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF1    FGF2    FGF3     FGF4   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway   FLT3LG    FLT3    GRB2     SOS1   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway  FLT3LG    FLT3    GRB2     SOS1   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway     FLT3LG    FLT3  STAT5A   STAT5B   \n",
       "Hedgehog_signaling_pathway                 SHH   PTCH1     SMO     SUFU   \n",
       "HGF-MET-PI3K_signaling_pathway             HGF     MET    GAB1   PIK3CA   \n",
       "HGF-MET-RAS-ERK_signaling_pathway          HGF     MET    GRB2     SOS1   \n",
       "HIF-1_signaling_pathway                  HIF1A    ARNT  SLC2A1    VEGFA   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         IGF1    IGF2   IGF1R     GRB2   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       IGF2   IGF1R  PIK3CA   PIK3CB   \n",
       "Intrinsic_apoptotic_pathway             PMAIP1    BBC3     BAD  BCL2L11   \n",
       "KEAP1-NRF2_signaling_pathway             KEAP1  NFE2L2   HMOX1     NQO1   \n",
       "KITLG-KIT-PI3K_signaling_pathway         KITLG     KIT  PIK3CA   PIK3CB   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway      KITLG     KIT    GRB2     SOS1   \n",
       "MDM2-p21-Cell_cycle_G1-S                CDKN2A    MDM2    TP53   CDKN1A   \n",
       "NOTCH_signaling_pathway                   DLL1    DLL3    DLL4     JAG1   \n",
       "p15-Cell_cycle_G1-S                        MYC     MAX  ZBTB17   CDKN2B   \n",
       "p16-Cell_cycle_G1-S                     CDKN2A   CCND1   CCND2    CCND3   \n",
       "p27-Cell_cycle_G1-S                       SKP1    CUL1    RBX1     SKP2   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway        PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway     PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PTEN-PIP3-AKT_signaling_pathway           PTEN    AKT1    AKT2     AKT3   \n",
       "Telomerase_activity                       TERC     NaN     NaN      NaN   \n",
       "TGFA-EGFR-PI3K_signaling_pathway         TGFB1   TGFB2   TGFB3   TGFBR2   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      TGFA    EGFR  PIK3CA   PIK3CB   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway       TGFA    EGFR   PLCG1    PLCG2   \n",
       "TGF-beta_signaling_pathway                TGFA    EGFR    GRB2     SOS1   \n",
       "WNT_signaling_pathway                     WNT1    WNT2   WNT2B     WNT3   \n",
       "NaN                                          \u001a     NaN     NaN      NaN   \n",
       "\n",
       "                                            5       6       7       8   \\\n",
       "0                                                                        \n",
       "Androgen_receptor_signaling_pathway        NaN     NaN     NaN     NaN   \n",
       "Cytokine-Jak-STAT_signaling_pathway        IL6     IL7   IL12A   IL12B   \n",
       "DCC-apoptotic_pathway                      NaN     NaN     NaN     NaN   \n",
       "EGF-EGFR-PI3K_signaling_pathway         PIK3CD    AKT1    AKT2    AKT3   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway     CALM1   CALM2   CALM3   CAMK1   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       SOS1    SOS2    HRAS    KRAS   \n",
       "EGF-Jak-STAT_signaling_pathway           STAT3  STAT5A  STAT5B     NaN   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF5    FGF6    FGF7    FGF8   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF5    FGF6    FGF7    FGF8   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway    SOS2    HRAS    KRAS    NRAS   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway        NaN     NaN     NaN     NaN   \n",
       "Hedgehog_signaling_pathway                GLI1    GLI2    GLI3    GLI1   \n",
       "HGF-MET-PI3K_signaling_pathway          PIK3CB  PIK3CD    AKT1    AKT2   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         SOS2    HRAS    KRAS    NRAS   \n",
       "HIF-1_signaling_pathway                  TGFB1   TGFB2   TGFB3   PDGFB   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         SOS1    SOS2    HRAS    KRAS   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway     PIK3CD    AKT1    AKT2    AKT3   \n",
       "Intrinsic_apoptotic_pathway               BCL2  BCL2L1     BAX    BAK1   \n",
       "KEAP1-NRF2_signaling_pathway             GSTO2   GSTA5   GSTA1   GSTA2   \n",
       "KITLG-KIT-PI3K_signaling_pathway        PIK3CD    AKT1    AKT2    AKT3   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       SOS2    HRAS    KRAS    NRAS   \n",
       "MDM2-p21-Cell_cycle_G1-S                 CCND1   CCND2   CCND3    CDK4   \n",
       "NOTCH_signaling_pathway                   JAG2  NOTCH1  NOTCH2  NOTCH3   \n",
       "p15-Cell_cycle_G1-S                      CCND1   CCND2   CCND3    CDK4   \n",
       "p16-Cell_cycle_G1-S                       CDK4    CDK6     RB1    E2F1   \n",
       "p27-Cell_cycle_G1-S                     CDKN1B   CCNA2   CCNA1   CCNE1   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway       PIK3CA  PIK3CB  PIK3CD    AKT1   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   PLCG1   PLCG2   CALM1   CALM2   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      GRB2    SOS1    SOS2    HRAS   \n",
       "PTEN-PIP3-AKT_signaling_pathway            NaN     NaN     NaN     NaN   \n",
       "Telomerase_activity                        NaN     NaN     NaN     NaN   \n",
       "TGFA-EGFR-PI3K_signaling_pathway        TGFBR1   SMAD2   SMAD3   SMAD4   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway    PIK3CD    AKT1    AKT2    AKT3   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway      PRKCA   PRKCB   PRKCG    ELK1   \n",
       "TGF-beta_signaling_pathway                SOS2    HRAS    KRAS    NRAS   \n",
       "WNT_signaling_pathway                    WNT3A    WNT4   WNT5A   WNT5B   \n",
       "NaN                                        NaN     NaN     NaN     NaN   \n",
       "\n",
       "                                            9        10  ...     37     38  \\\n",
       "0                                                        ...                 \n",
       "Androgen_receptor_signaling_pathway        NaN      NaN  ...    NaN    NaN   \n",
       "Cytokine-Jak-STAT_signaling_pathway       IL13     IL15  ...   JAK3  STAT1   \n",
       "DCC-apoptotic_pathway                      NaN      NaN  ...    NaN    NaN   \n",
       "EGF-EGFR-PI3K_signaling_pathway            BAD      NaN  ...    NaN    NaN   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway    CAMK1D   CAMK1G  ...    NaN    NaN   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        ARAF     BRAF  ...    NaN    NaN   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway   RALGDS     RALA  ...    NaN    NaN   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway   RASSF1   RASSF5  ...    NaN    NaN   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       NRAS     ARAF  ...    NaN    NaN   \n",
       "EGF-Jak-STAT_signaling_pathway             NaN      NaN  ...    NaN    NaN   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF9    FGF10  ...    NaN    NaN   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF9    FGF10  ...    NaN    NaN   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     ARAF     BRAF  ...    NaN    NaN   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway  PIK3CA   PIK3CB  ...    NaN    NaN   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway        NaN      NaN  ...    NaN    NaN   \n",
       "Hedgehog_signaling_pathway               PTCH1    PTCH2  ...    NaN    NaN   \n",
       "HGF-MET-PI3K_signaling_pathway            AKT3      BAD  ...    NaN    NaN   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         ARAF     BRAF  ...    NaN    NaN   \n",
       "HIF-1_signaling_pathway                   TGFA      NaN  ...    NaN    NaN   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         NRAS     ARAF  ...    NaN    NaN   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       MTOR  RPS6KB1  ...    NaN    NaN   \n",
       "Intrinsic_apoptotic_pathway               CYCS    APAF1  ...    NaN    NaN   \n",
       "KEAP1-NRF2_signaling_pathway             GSTA3    GSTA4  ...    NaN    NaN   \n",
       "KITLG-KIT-PI3K_signaling_pathway          MTOR  RPS6KB1  ...    NaN    NaN   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       ARAF     BRAF  ...    NaN    NaN   \n",
       "MDM2-p21-Cell_cycle_G1-S                  CDK6      RB1  ...    NaN    NaN   \n",
       "NOTCH_signaling_pathway                 NOTCH4     HES1  ...    NaN    NaN   \n",
       "p15-Cell_cycle_G1-S                       CDK6      RB1  ...    NaN    NaN   \n",
       "p16-Cell_cycle_G1-S                       E2F2     E2F3  ...    NaN    NaN   \n",
       "p27-Cell_cycle_G1-S                      CCNE2     CDK2  ...    NaN    NaN   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway         AKT2     AKT3  ...    NaN    NaN   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   CALM3    CAMK1  ...    NaN    NaN   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      KRAS     NRAS  ...    NaN    NaN   \n",
       "PTEN-PIP3-AKT_signaling_pathway            NaN      NaN  ...    NaN    NaN   \n",
       "Telomerase_activity                        NaN      NaN  ...    NaN    NaN   \n",
       "TGFA-EGFR-PI3K_signaling_pathway           NaN      NaN  ...    NaN    NaN   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      MTOR      NaN  ...    NaN    NaN   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway        NaN      NaN  ...    NaN    NaN   \n",
       "TGF-beta_signaling_pathway                ARAF     BRAF  ...    NaN    NaN   \n",
       "WNT_signaling_pathway                     WNT6    WNT7A  ...  AXIN1  AXIN2   \n",
       "NaN                                        NaN      NaN  ...    NaN    NaN   \n",
       "\n",
       "                                           39      40     41      42      43  \\\n",
       "0                                                                              \n",
       "Androgen_receptor_signaling_pathway       NaN     NaN    NaN     NaN     NaN   \n",
       "Cytokine-Jak-STAT_signaling_pathway     STAT2   STAT3  STAT4  STAT5A  STAT5B   \n",
       "DCC-apoptotic_pathway                     NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-EGFR-PI3K_signaling_pathway           NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway      NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway     NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway     NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       NaN     NaN    NaN     NaN     NaN   \n",
       "EGF-Jak-STAT_signaling_pathway            NaN     NaN    NaN     NaN     NaN   \n",
       "FGF-FGFR-PI3K_signaling_pathway           NaN     NaN    NaN     NaN     NaN   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        NaN     NaN    NaN     NaN     NaN   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     NaN     NaN    NaN     NaN     NaN   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway    NaN     NaN    NaN     NaN     NaN   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway       NaN     NaN    NaN     NaN     NaN   \n",
       "Hedgehog_signaling_pathway                NaN     NaN    NaN     NaN     NaN   \n",
       "HGF-MET-PI3K_signaling_pathway            NaN     NaN    NaN     NaN     NaN   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         NaN     NaN    NaN     NaN     NaN   \n",
       "HIF-1_signaling_pathway                   NaN     NaN    NaN     NaN     NaN   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         NaN     NaN    NaN     NaN     NaN   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       NaN     NaN    NaN     NaN     NaN   \n",
       "Intrinsic_apoptotic_pathway               NaN     NaN    NaN     NaN     NaN   \n",
       "KEAP1-NRF2_signaling_pathway              NaN     NaN    NaN     NaN     NaN   \n",
       "KITLG-KIT-PI3K_signaling_pathway          NaN     NaN    NaN     NaN     NaN   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       NaN     NaN    NaN     NaN     NaN   \n",
       "MDM2-p21-Cell_cycle_G1-S                  NaN     NaN    NaN     NaN     NaN   \n",
       "NOTCH_signaling_pathway                   NaN     NaN    NaN     NaN     NaN   \n",
       "p15-Cell_cycle_G1-S                       NaN     NaN    NaN     NaN     NaN   \n",
       "p16-Cell_cycle_G1-S                       NaN     NaN    NaN     NaN     NaN   \n",
       "p27-Cell_cycle_G1-S                       NaN     NaN    NaN     NaN     NaN   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway         NaN     NaN    NaN     NaN     NaN   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway    NaN     NaN    NaN     NaN     NaN   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      NaN     NaN    NaN     NaN     NaN   \n",
       "PTEN-PIP3-AKT_signaling_pathway           NaN     NaN    NaN     NaN     NaN   \n",
       "Telomerase_activity                       NaN     NaN    NaN     NaN     NaN   \n",
       "TGFA-EGFR-PI3K_signaling_pathway          NaN     NaN    NaN     NaN     NaN   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      NaN     NaN    NaN     NaN     NaN   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway       NaN     NaN    NaN     NaN     NaN   \n",
       "TGF-beta_signaling_pathway                NaN     NaN    NaN     NaN     NaN   \n",
       "WNT_signaling_pathway                     APC  CTNNB1   TCF7  TCF7L1  TCF7L2   \n",
       "NaN                                       NaN     NaN    NaN     NaN     NaN   \n",
       "\n",
       "                                           44    45     46  \n",
       "0                                                           \n",
       "Androgen_receptor_signaling_pathway       NaN   NaN    NaN  \n",
       "Cytokine-Jak-STAT_signaling_pathway     STAT6  PIM1    NaN  \n",
       "DCC-apoptotic_pathway                     NaN   NaN    NaN  \n",
       "EGF-EGFR-PI3K_signaling_pathway           NaN   NaN    NaN  \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway      NaN   NaN    NaN  \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        NaN   NaN    NaN  \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway     NaN   NaN    NaN  \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway     NaN   NaN    NaN  \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       NaN   NaN    NaN  \n",
       "EGF-Jak-STAT_signaling_pathway            NaN   NaN    NaN  \n",
       "FGF-FGFR-PI3K_signaling_pathway           NaN   NaN    NaN  \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        NaN   NaN    NaN  \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     NaN   NaN    NaN  \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway    NaN   NaN    NaN  \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway       NaN   NaN    NaN  \n",
       "Hedgehog_signaling_pathway                NaN   NaN    NaN  \n",
       "HGF-MET-PI3K_signaling_pathway            NaN   NaN    NaN  \n",
       "HGF-MET-RAS-ERK_signaling_pathway         NaN   NaN    NaN  \n",
       "HIF-1_signaling_pathway                   NaN   NaN    NaN  \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         NaN   NaN    NaN  \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       NaN   NaN    NaN  \n",
       "Intrinsic_apoptotic_pathway               NaN   NaN    NaN  \n",
       "KEAP1-NRF2_signaling_pathway              NaN   NaN    NaN  \n",
       "KITLG-KIT-PI3K_signaling_pathway          NaN   NaN    NaN  \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       NaN   NaN    NaN  \n",
       "MDM2-p21-Cell_cycle_G1-S                  NaN   NaN    NaN  \n",
       "NOTCH_signaling_pathway                   NaN   NaN    NaN  \n",
       "p15-Cell_cycle_G1-S                       NaN   NaN    NaN  \n",
       "p16-Cell_cycle_G1-S                       NaN   NaN    NaN  \n",
       "p27-Cell_cycle_G1-S                       NaN   NaN    NaN  \n",
       "PDGF-PDGFR-PI3K_signaling_pathway         NaN   NaN    NaN  \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway    NaN   NaN    NaN  \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      NaN   NaN    NaN  \n",
       "PTEN-PIP3-AKT_signaling_pathway           NaN   NaN    NaN  \n",
       "Telomerase_activity                       NaN   NaN    NaN  \n",
       "TGFA-EGFR-PI3K_signaling_pathway          NaN   NaN    NaN  \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      NaN   NaN    NaN  \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway       NaN   NaN    NaN  \n",
       "TGF-beta_signaling_pathway                NaN   NaN    NaN  \n",
       "WNT_signaling_pathway                    LEF1   MYC  CCND1  \n",
       "NaN                                       NaN   NaN    NaN  \n",
       "\n",
       "[41 rows x 46 columns]"
      ]
     },
     "execution_count": 2,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pathways=pd.read_csv('D:/MyData/Pathway_Attention/data/All_Sub-pathways/allPathways.csv',sep='\\,',engine='python',header=None,index_col=0)\n",
    "pathways"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "6024167e",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>10</th>\n",
       "      <th>...</th>\n",
       "      <th>37</th>\n",
       "      <th>38</th>\n",
       "      <th>39</th>\n",
       "      <th>40</th>\n",
       "      <th>41</th>\n",
       "      <th>42</th>\n",
       "      <th>43</th>\n",
       "      <th>44</th>\n",
       "      <th>45</th>\n",
       "      <th>46</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>Androgen_receptor_signaling_pathway</th>\n",
       "      <td>AR</td>\n",
       "      <td>KLK3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Cytokine-Jak-STAT_signaling_pathway</th>\n",
       "      <td>IL2</td>\n",
       "      <td>IL3</td>\n",
       "      <td>IL4</td>\n",
       "      <td>IL5</td>\n",
       "      <td>IL6</td>\n",
       "      <td>IL7</td>\n",
       "      <td>IL12A</td>\n",
       "      <td>IL12B</td>\n",
       "      <td>IL13</td>\n",
       "      <td>IL15</td>\n",
       "      <td>...</td>\n",
       "      <td>JAK3</td>\n",
       "      <td>STAT1</td>\n",
       "      <td>STAT2</td>\n",
       "      <td>STAT3</td>\n",
       "      <td>STAT4</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>STAT6</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DCC-apoptotic_pathway</th>\n",
       "      <td>CASP3</td>\n",
       "      <td>DCC</td>\n",
       "      <td>CASP9</td>\n",
       "      <td>APPL1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-PI3K_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-PLCG-CAMK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>CALM1</td>\n",
       "      <td>CALM2</td>\n",
       "      <td>CALM3</td>\n",
       "      <td>CAMK1</td>\n",
       "      <td>CAMK1D</td>\n",
       "      <td>CAMK1G</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-RalGDS_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>RALGDS</td>\n",
       "      <td>RALA</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-RASSF1_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>RASSF1</td>\n",
       "      <td>RASSF5</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-ERBB2-RAS-ERK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>ERBB2</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-Jak-STAT_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>JAK1</td>\n",
       "      <td>STAT1</td>\n",
       "      <td>STAT3</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGF-FGFR-PI3K_signaling_pathway</th>\n",
       "      <td>FGF1</td>\n",
       "      <td>FGF2</td>\n",
       "      <td>FGF3</td>\n",
       "      <td>FGF4</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>FGF6</td>\n",
       "      <td>FGF7</td>\n",
       "      <td>FGF8</td>\n",
       "      <td>FGF9</td>\n",
       "      <td>FGF10</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGF-FGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>FGF1</td>\n",
       "      <td>FGF2</td>\n",
       "      <td>FGF3</td>\n",
       "      <td>FGF4</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>FGF6</td>\n",
       "      <td>FGF7</td>\n",
       "      <td>FGF8</td>\n",
       "      <td>FGF9</td>\n",
       "      <td>FGF10</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-RAS-ERK_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-RAS-PI3K_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-STAT5_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Hedgehog_signaling_pathway</th>\n",
       "      <td>SHH</td>\n",
       "      <td>PTCH1</td>\n",
       "      <td>SMO</td>\n",
       "      <td>SUFU</td>\n",
       "      <td>GLI1</td>\n",
       "      <td>GLI2</td>\n",
       "      <td>GLI3</td>\n",
       "      <td>GLI1</td>\n",
       "      <td>PTCH1</td>\n",
       "      <td>PTCH2</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HGF-MET-PI3K_signaling_pathway</th>\n",
       "      <td>HGF</td>\n",
       "      <td>MET</td>\n",
       "      <td>GAB1</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HGF-MET-RAS-ERK_signaling_pathway</th>\n",
       "      <td>HGF</td>\n",
       "      <td>MET</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HIF-1_signaling_pathway</th>\n",
       "      <td>HIF1A</td>\n",
       "      <td>ARNT</td>\n",
       "      <td>SLC2A1</td>\n",
       "      <td>VEGFA</td>\n",
       "      <td>TGFB1</td>\n",
       "      <td>TGFB2</td>\n",
       "      <td>TGFB3</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>TGFA</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF2-IGF1R-PI3K_signaling_pathway</th>\n",
       "      <td>IGF1</td>\n",
       "      <td>IGF2</td>\n",
       "      <td>IGF1R</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF-IGF1R-RAS-ERK_signaling_pathway</th>\n",
       "      <td>IGF2</td>\n",
       "      <td>IGF1R</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>RPS6KB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Intrinsic_apoptotic_pathway</th>\n",
       "      <td>PMAIP1</td>\n",
       "      <td>BBC3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>BCL2L11</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>BCL2L1</td>\n",
       "      <td>BAX</td>\n",
       "      <td>BAK1</td>\n",
       "      <td>CYCS</td>\n",
       "      <td>APAF1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KEAP1-NRF2_signaling_pathway</th>\n",
       "      <td>KEAP1</td>\n",
       "      <td>NFE2L2</td>\n",
       "      <td>HMOX1</td>\n",
       "      <td>NQO1</td>\n",
       "      <td>GSTO2</td>\n",
       "      <td>GSTA5</td>\n",
       "      <td>GSTA1</td>\n",
       "      <td>GSTA2</td>\n",
       "      <td>GSTA3</td>\n",
       "      <td>GSTA4</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KITLG-KIT-PI3K_signaling_pathway</th>\n",
       "      <td>KITLG</td>\n",
       "      <td>KIT</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>RPS6KB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KITLG-KIT-RAS-ERK_signaling_pathway</th>\n",
       "      <td>KITLG</td>\n",
       "      <td>KIT</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MDM2-p21-Cell_cycle_G1-S</th>\n",
       "      <td>CDKN2A</td>\n",
       "      <td>MDM2</td>\n",
       "      <td>TP53</td>\n",
       "      <td>CDKN1A</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NOTCH_signaling_pathway</th>\n",
       "      <td>DLL1</td>\n",
       "      <td>DLL3</td>\n",
       "      <td>DLL4</td>\n",
       "      <td>JAG1</td>\n",
       "      <td>JAG2</td>\n",
       "      <td>NOTCH1</td>\n",
       "      <td>NOTCH2</td>\n",
       "      <td>NOTCH3</td>\n",
       "      <td>NOTCH4</td>\n",
       "      <td>HES1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p15-Cell_cycle_G1-S</th>\n",
       "      <td>MYC</td>\n",
       "      <td>MAX</td>\n",
       "      <td>ZBTB17</td>\n",
       "      <td>CDKN2B</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p16-Cell_cycle_G1-S</th>\n",
       "      <td>CDKN2A</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>E2F1</td>\n",
       "      <td>E2F2</td>\n",
       "      <td>E2F3</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p27-Cell_cycle_G1-S</th>\n",
       "      <td>SKP1</td>\n",
       "      <td>CUL1</td>\n",
       "      <td>RBX1</td>\n",
       "      <td>SKP2</td>\n",
       "      <td>CDKN1B</td>\n",
       "      <td>CCNA2</td>\n",
       "      <td>CCNA1</td>\n",
       "      <td>CCNE1</td>\n",
       "      <td>CCNE2</td>\n",
       "      <td>CDK2</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-PI3K_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-PLCG-CAMK_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>CALM1</td>\n",
       "      <td>CALM2</td>\n",
       "      <td>CALM3</td>\n",
       "      <td>CAMK1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTEN-PIP3-AKT_signaling_pathway</th>\n",
       "      <td>PTEN</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Telomerase_activity</th>\n",
       "      <td>TERC</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-PI3K_signaling_pathway</th>\n",
       "      <td>TGFB1</td>\n",
       "      <td>TGFB2</td>\n",
       "      <td>TGFB3</td>\n",
       "      <td>TGFBR2</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>SMAD2</td>\n",
       "      <td>SMAD3</td>\n",
       "      <td>SMAD4</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-PLCG-PKC_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>PRKCA</td>\n",
       "      <td>PRKCB</td>\n",
       "      <td>PRKCG</td>\n",
       "      <td>ELK1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGF-beta_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WNT_signaling_pathway</th>\n",
       "      <td>WNT1</td>\n",
       "      <td>WNT2</td>\n",
       "      <td>WNT2B</td>\n",
       "      <td>WNT3</td>\n",
       "      <td>WNT3A</td>\n",
       "      <td>WNT4</td>\n",
       "      <td>WNT5A</td>\n",
       "      <td>WNT5B</td>\n",
       "      <td>WNT6</td>\n",
       "      <td>WNT7A</td>\n",
       "      <td>...</td>\n",
       "      <td>AXIN1</td>\n",
       "      <td>AXIN2</td>\n",
       "      <td>APC</td>\n",
       "      <td>CTNNB1</td>\n",
       "      <td>TCF7</td>\n",
       "      <td>TCF7L1</td>\n",
       "      <td>TCF7L2</td>\n",
       "      <td>LEF1</td>\n",
       "      <td>MYC</td>\n",
       "      <td>CCND1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NaN</th>\n",
       "      <td>\u001a</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>41 rows × 46 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                            1       2       3        4   \\\n",
       "0                                                                         \n",
       "Androgen_receptor_signaling_pathway         AR    KLK3       0        0   \n",
       "Cytokine-Jak-STAT_signaling_pathway        IL2     IL3     IL4      IL5   \n",
       "DCC-apoptotic_pathway                    CASP3     DCC   CASP9    APPL1   \n",
       "EGF-EGFR-PI3K_signaling_pathway            EGF    EGFR  PIK3CA   PIK3CB   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway       EGF    EGFR   PLCG1    PLCG2   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway         EGF    EGFR    GRB2     SOS1   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway      EGF    EGFR    GRB2     SOS1   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway      EGF    EGFR    GRB2     SOS1   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway        EGF   ERBB2    EGFR     GRB2   \n",
       "EGF-Jak-STAT_signaling_pathway             EGF    EGFR    JAK1    STAT1   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF1    FGF2    FGF3     FGF4   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF1    FGF2    FGF3     FGF4   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway   FLT3LG    FLT3    GRB2     SOS1   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway  FLT3LG    FLT3    GRB2     SOS1   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway     FLT3LG    FLT3  STAT5A   STAT5B   \n",
       "Hedgehog_signaling_pathway                 SHH   PTCH1     SMO     SUFU   \n",
       "HGF-MET-PI3K_signaling_pathway             HGF     MET    GAB1   PIK3CA   \n",
       "HGF-MET-RAS-ERK_signaling_pathway          HGF     MET    GRB2     SOS1   \n",
       "HIF-1_signaling_pathway                  HIF1A    ARNT  SLC2A1    VEGFA   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         IGF1    IGF2   IGF1R     GRB2   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       IGF2   IGF1R  PIK3CA   PIK3CB   \n",
       "Intrinsic_apoptotic_pathway             PMAIP1    BBC3     BAD  BCL2L11   \n",
       "KEAP1-NRF2_signaling_pathway             KEAP1  NFE2L2   HMOX1     NQO1   \n",
       "KITLG-KIT-PI3K_signaling_pathway         KITLG     KIT  PIK3CA   PIK3CB   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway      KITLG     KIT    GRB2     SOS1   \n",
       "MDM2-p21-Cell_cycle_G1-S                CDKN2A    MDM2    TP53   CDKN1A   \n",
       "NOTCH_signaling_pathway                   DLL1    DLL3    DLL4     JAG1   \n",
       "p15-Cell_cycle_G1-S                        MYC     MAX  ZBTB17   CDKN2B   \n",
       "p16-Cell_cycle_G1-S                     CDKN2A   CCND1   CCND2    CCND3   \n",
       "p27-Cell_cycle_G1-S                       SKP1    CUL1    RBX1     SKP2   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway        PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway     PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PTEN-PIP3-AKT_signaling_pathway           PTEN    AKT1    AKT2     AKT3   \n",
       "Telomerase_activity                       TERC       0       0        0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway         TGFB1   TGFB2   TGFB3   TGFBR2   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      TGFA    EGFR  PIK3CA   PIK3CB   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway       TGFA    EGFR   PLCG1    PLCG2   \n",
       "TGF-beta_signaling_pathway                TGFA    EGFR    GRB2     SOS1   \n",
       "WNT_signaling_pathway                     WNT1    WNT2   WNT2B     WNT3   \n",
       "NaN                                          \u001a       0       0        0   \n",
       "\n",
       "                                            5       6       7       8   \\\n",
       "0                                                                        \n",
       "Androgen_receptor_signaling_pathway          0       0       0       0   \n",
       "Cytokine-Jak-STAT_signaling_pathway        IL6     IL7   IL12A   IL12B   \n",
       "DCC-apoptotic_pathway                        0       0       0       0   \n",
       "EGF-EGFR-PI3K_signaling_pathway         PIK3CD    AKT1    AKT2    AKT3   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway     CALM1   CALM2   CALM3   CAMK1   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       SOS1    SOS2    HRAS    KRAS   \n",
       "EGF-Jak-STAT_signaling_pathway           STAT3  STAT5A  STAT5B       0   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF5    FGF6    FGF7    FGF8   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF5    FGF6    FGF7    FGF8   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway    SOS2    HRAS    KRAS    NRAS   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway          0       0       0       0   \n",
       "Hedgehog_signaling_pathway                GLI1    GLI2    GLI3    GLI1   \n",
       "HGF-MET-PI3K_signaling_pathway          PIK3CB  PIK3CD    AKT1    AKT2   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         SOS2    HRAS    KRAS    NRAS   \n",
       "HIF-1_signaling_pathway                  TGFB1   TGFB2   TGFB3   PDGFB   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         SOS1    SOS2    HRAS    KRAS   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway     PIK3CD    AKT1    AKT2    AKT3   \n",
       "Intrinsic_apoptotic_pathway               BCL2  BCL2L1     BAX    BAK1   \n",
       "KEAP1-NRF2_signaling_pathway             GSTO2   GSTA5   GSTA1   GSTA2   \n",
       "KITLG-KIT-PI3K_signaling_pathway        PIK3CD    AKT1    AKT2    AKT3   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       SOS2    HRAS    KRAS    NRAS   \n",
       "MDM2-p21-Cell_cycle_G1-S                 CCND1   CCND2   CCND3    CDK4   \n",
       "NOTCH_signaling_pathway                   JAG2  NOTCH1  NOTCH2  NOTCH3   \n",
       "p15-Cell_cycle_G1-S                      CCND1   CCND2   CCND3    CDK4   \n",
       "p16-Cell_cycle_G1-S                       CDK4    CDK6     RB1    E2F1   \n",
       "p27-Cell_cycle_G1-S                     CDKN1B   CCNA2   CCNA1   CCNE1   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway       PIK3CA  PIK3CB  PIK3CD    AKT1   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   PLCG1   PLCG2   CALM1   CALM2   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      GRB2    SOS1    SOS2    HRAS   \n",
       "PTEN-PIP3-AKT_signaling_pathway              0       0       0       0   \n",
       "Telomerase_activity                          0       0       0       0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway        TGFBR1   SMAD2   SMAD3   SMAD4   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway    PIK3CD    AKT1    AKT2    AKT3   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway      PRKCA   PRKCB   PRKCG    ELK1   \n",
       "TGF-beta_signaling_pathway                SOS2    HRAS    KRAS    NRAS   \n",
       "WNT_signaling_pathway                    WNT3A    WNT4   WNT5A   WNT5B   \n",
       "NaN                                          0       0       0       0   \n",
       "\n",
       "                                            9        10  ...     37     38  \\\n",
       "0                                                        ...                 \n",
       "Androgen_receptor_signaling_pathway          0        0  ...      0      0   \n",
       "Cytokine-Jak-STAT_signaling_pathway       IL13     IL15  ...   JAK3  STAT1   \n",
       "DCC-apoptotic_pathway                        0        0  ...      0      0   \n",
       "EGF-EGFR-PI3K_signaling_pathway            BAD        0  ...      0      0   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway    CAMK1D   CAMK1G  ...      0      0   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        ARAF     BRAF  ...      0      0   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway   RALGDS     RALA  ...      0      0   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway   RASSF1   RASSF5  ...      0      0   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       NRAS     ARAF  ...      0      0   \n",
       "EGF-Jak-STAT_signaling_pathway               0        0  ...      0      0   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF9    FGF10  ...      0      0   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF9    FGF10  ...      0      0   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     ARAF     BRAF  ...      0      0   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway  PIK3CA   PIK3CB  ...      0      0   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway          0        0  ...      0      0   \n",
       "Hedgehog_signaling_pathway               PTCH1    PTCH2  ...      0      0   \n",
       "HGF-MET-PI3K_signaling_pathway            AKT3      BAD  ...      0      0   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         ARAF     BRAF  ...      0      0   \n",
       "HIF-1_signaling_pathway                   TGFA        0  ...      0      0   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         NRAS     ARAF  ...      0      0   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       MTOR  RPS6KB1  ...      0      0   \n",
       "Intrinsic_apoptotic_pathway               CYCS    APAF1  ...      0      0   \n",
       "KEAP1-NRF2_signaling_pathway             GSTA3    GSTA4  ...      0      0   \n",
       "KITLG-KIT-PI3K_signaling_pathway          MTOR  RPS6KB1  ...      0      0   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       ARAF     BRAF  ...      0      0   \n",
       "MDM2-p21-Cell_cycle_G1-S                  CDK6      RB1  ...      0      0   \n",
       "NOTCH_signaling_pathway                 NOTCH4     HES1  ...      0      0   \n",
       "p15-Cell_cycle_G1-S                       CDK6      RB1  ...      0      0   \n",
       "p16-Cell_cycle_G1-S                       E2F2     E2F3  ...      0      0   \n",
       "p27-Cell_cycle_G1-S                      CCNE2     CDK2  ...      0      0   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway         AKT2     AKT3  ...      0      0   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   CALM3    CAMK1  ...      0      0   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      KRAS     NRAS  ...      0      0   \n",
       "PTEN-PIP3-AKT_signaling_pathway              0        0  ...      0      0   \n",
       "Telomerase_activity                          0        0  ...      0      0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway             0        0  ...      0      0   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      MTOR        0  ...      0      0   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway          0        0  ...      0      0   \n",
       "TGF-beta_signaling_pathway                ARAF     BRAF  ...      0      0   \n",
       "WNT_signaling_pathway                     WNT6    WNT7A  ...  AXIN1  AXIN2   \n",
       "NaN                                          0        0  ...      0      0   \n",
       "\n",
       "                                           39      40     41      42      43  \\\n",
       "0                                                                              \n",
       "Androgen_receptor_signaling_pathway         0       0      0       0       0   \n",
       "Cytokine-Jak-STAT_signaling_pathway     STAT2   STAT3  STAT4  STAT5A  STAT5B   \n",
       "DCC-apoptotic_pathway                       0       0      0       0       0   \n",
       "EGF-EGFR-PI3K_signaling_pathway             0       0      0       0       0   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway        0       0      0       0       0   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway          0       0      0       0       0   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway       0       0      0       0       0   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway       0       0      0       0       0   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "EGF-Jak-STAT_signaling_pathway              0       0      0       0       0   \n",
       "FGF-FGFR-PI3K_signaling_pathway             0       0      0       0       0   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway          0       0      0       0       0   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway       0       0      0       0       0   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway      0       0      0       0       0   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway         0       0      0       0       0   \n",
       "Hedgehog_signaling_pathway                  0       0      0       0       0   \n",
       "HGF-MET-PI3K_signaling_pathway              0       0      0       0       0   \n",
       "HGF-MET-RAS-ERK_signaling_pathway           0       0      0       0       0   \n",
       "HIF-1_signaling_pathway                     0       0      0       0       0   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway           0       0      0       0       0   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "Intrinsic_apoptotic_pathway                 0       0      0       0       0   \n",
       "KEAP1-NRF2_signaling_pathway                0       0      0       0       0   \n",
       "KITLG-KIT-PI3K_signaling_pathway            0       0      0       0       0   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "MDM2-p21-Cell_cycle_G1-S                    0       0      0       0       0   \n",
       "NOTCH_signaling_pathway                     0       0      0       0       0   \n",
       "p15-Cell_cycle_G1-S                         0       0      0       0       0   \n",
       "p16-Cell_cycle_G1-S                         0       0      0       0       0   \n",
       "p27-Cell_cycle_G1-S                         0       0      0       0       0   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway           0       0      0       0       0   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway      0       0      0       0       0   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway        0       0      0       0       0   \n",
       "PTEN-PIP3-AKT_signaling_pathway             0       0      0       0       0   \n",
       "Telomerase_activity                         0       0      0       0       0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway            0       0      0       0       0   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway        0       0      0       0       0   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "TGF-beta_signaling_pathway                  0       0      0       0       0   \n",
       "WNT_signaling_pathway                     APC  CTNNB1   TCF7  TCF7L1  TCF7L2   \n",
       "NaN                                         0       0      0       0       0   \n",
       "\n",
       "                                           44    45     46  \n",
       "0                                                           \n",
       "Androgen_receptor_signaling_pathway         0     0      0  \n",
       "Cytokine-Jak-STAT_signaling_pathway     STAT6  PIM1      0  \n",
       "DCC-apoptotic_pathway                       0     0      0  \n",
       "EGF-EGFR-PI3K_signaling_pathway             0     0      0  \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway        0     0      0  \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway          0     0      0  \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway       0     0      0  \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway       0     0      0  \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway         0     0      0  \n",
       "EGF-Jak-STAT_signaling_pathway              0     0      0  \n",
       "FGF-FGFR-PI3K_signaling_pathway             0     0      0  \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway          0     0      0  \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway       0     0      0  \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway      0     0      0  \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway         0     0      0  \n",
       "Hedgehog_signaling_pathway                  0     0      0  \n",
       "HGF-MET-PI3K_signaling_pathway              0     0      0  \n",
       "HGF-MET-RAS-ERK_signaling_pathway           0     0      0  \n",
       "HIF-1_signaling_pathway                     0     0      0  \n",
       "IGF2-IGF1R-PI3K_signaling_pathway           0     0      0  \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway         0     0      0  \n",
       "Intrinsic_apoptotic_pathway                 0     0      0  \n",
       "KEAP1-NRF2_signaling_pathway                0     0      0  \n",
       "KITLG-KIT-PI3K_signaling_pathway            0     0      0  \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway         0     0      0  \n",
       "MDM2-p21-Cell_cycle_G1-S                    0     0      0  \n",
       "NOTCH_signaling_pathway                     0     0      0  \n",
       "p15-Cell_cycle_G1-S                         0     0      0  \n",
       "p16-Cell_cycle_G1-S                         0     0      0  \n",
       "p27-Cell_cycle_G1-S                         0     0      0  \n",
       "PDGF-PDGFR-PI3K_signaling_pathway           0     0      0  \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway      0     0      0  \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway        0     0      0  \n",
       "PTEN-PIP3-AKT_signaling_pathway             0     0      0  \n",
       "Telomerase_activity                         0     0      0  \n",
       "TGFA-EGFR-PI3K_signaling_pathway            0     0      0  \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway        0     0      0  \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway         0     0      0  \n",
       "TGF-beta_signaling_pathway                  0     0      0  \n",
       "WNT_signaling_pathway                    LEF1   MYC  CCND1  \n",
       "NaN                                         0     0      0  \n",
       "\n",
       "[41 rows x 46 columns]"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pathways=pathways.fillna(0)\n",
    "pathways"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "id": "3e6a220e",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>1</th>\n",
       "      <th>2</th>\n",
       "      <th>3</th>\n",
       "      <th>4</th>\n",
       "      <th>5</th>\n",
       "      <th>6</th>\n",
       "      <th>7</th>\n",
       "      <th>8</th>\n",
       "      <th>9</th>\n",
       "      <th>10</th>\n",
       "      <th>...</th>\n",
       "      <th>37</th>\n",
       "      <th>38</th>\n",
       "      <th>39</th>\n",
       "      <th>40</th>\n",
       "      <th>41</th>\n",
       "      <th>42</th>\n",
       "      <th>43</th>\n",
       "      <th>44</th>\n",
       "      <th>45</th>\n",
       "      <th>46</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>Androgen_receptor_signaling_pathway</th>\n",
       "      <td>AR</td>\n",
       "      <td>KLK3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Cytokine-Jak-STAT_signaling_pathway</th>\n",
       "      <td>IL2</td>\n",
       "      <td>IL3</td>\n",
       "      <td>IL4</td>\n",
       "      <td>IL5</td>\n",
       "      <td>IL6</td>\n",
       "      <td>IL7</td>\n",
       "      <td>IL12A</td>\n",
       "      <td>IL12B</td>\n",
       "      <td>IL13</td>\n",
       "      <td>IL15</td>\n",
       "      <td>...</td>\n",
       "      <td>JAK3</td>\n",
       "      <td>STAT1</td>\n",
       "      <td>STAT2</td>\n",
       "      <td>STAT3</td>\n",
       "      <td>STAT4</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>STAT6</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DCC-apoptotic_pathway</th>\n",
       "      <td>CASP3</td>\n",
       "      <td>DCC</td>\n",
       "      <td>CASP9</td>\n",
       "      <td>APPL1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-PI3K_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-PLCG-CAMK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>CALM1</td>\n",
       "      <td>CALM2</td>\n",
       "      <td>CALM3</td>\n",
       "      <td>CAMK1</td>\n",
       "      <td>CAMK1D</td>\n",
       "      <td>CAMK1G</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-RalGDS_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>RALGDS</td>\n",
       "      <td>RALA</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-EGFR-RAS-RASSF1_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>RASSF1</td>\n",
       "      <td>RASSF5</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-ERBB2-RAS-ERK_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>ERBB2</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGF-Jak-STAT_signaling_pathway</th>\n",
       "      <td>EGF</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>JAK1</td>\n",
       "      <td>STAT1</td>\n",
       "      <td>STAT3</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGF-FGFR-PI3K_signaling_pathway</th>\n",
       "      <td>FGF1</td>\n",
       "      <td>FGF2</td>\n",
       "      <td>FGF3</td>\n",
       "      <td>FGF4</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>FGF6</td>\n",
       "      <td>FGF7</td>\n",
       "      <td>FGF8</td>\n",
       "      <td>FGF9</td>\n",
       "      <td>FGF10</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGF-FGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>FGF1</td>\n",
       "      <td>FGF2</td>\n",
       "      <td>FGF3</td>\n",
       "      <td>FGF4</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>FGF6</td>\n",
       "      <td>FGF7</td>\n",
       "      <td>FGF8</td>\n",
       "      <td>FGF9</td>\n",
       "      <td>FGF10</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-RAS-ERK_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-RAS-PI3K_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT3LG-FLT3-STAT5_signaling_pathway</th>\n",
       "      <td>FLT3LG</td>\n",
       "      <td>FLT3</td>\n",
       "      <td>STAT5A</td>\n",
       "      <td>STAT5B</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Hedgehog_signaling_pathway</th>\n",
       "      <td>SHH</td>\n",
       "      <td>PTCH1</td>\n",
       "      <td>SMO</td>\n",
       "      <td>SUFU</td>\n",
       "      <td>GLI1</td>\n",
       "      <td>GLI2</td>\n",
       "      <td>GLI3</td>\n",
       "      <td>GLI1</td>\n",
       "      <td>PTCH1</td>\n",
       "      <td>PTCH2</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HGF-MET-PI3K_signaling_pathway</th>\n",
       "      <td>HGF</td>\n",
       "      <td>MET</td>\n",
       "      <td>GAB1</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HGF-MET-RAS-ERK_signaling_pathway</th>\n",
       "      <td>HGF</td>\n",
       "      <td>MET</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HIF-1_signaling_pathway</th>\n",
       "      <td>HIF1A</td>\n",
       "      <td>ARNT</td>\n",
       "      <td>SLC2A1</td>\n",
       "      <td>VEGFA</td>\n",
       "      <td>TGFB1</td>\n",
       "      <td>TGFB2</td>\n",
       "      <td>TGFB3</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>TGFA</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF2-IGF1R-PI3K_signaling_pathway</th>\n",
       "      <td>IGF1</td>\n",
       "      <td>IGF2</td>\n",
       "      <td>IGF1R</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF-IGF1R-RAS-ERK_signaling_pathway</th>\n",
       "      <td>IGF2</td>\n",
       "      <td>IGF1R</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>RPS6KB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Intrinsic_apoptotic_pathway</th>\n",
       "      <td>PMAIP1</td>\n",
       "      <td>BBC3</td>\n",
       "      <td>BAD</td>\n",
       "      <td>BCL2L11</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>BCL2L1</td>\n",
       "      <td>BAX</td>\n",
       "      <td>BAK1</td>\n",
       "      <td>CYCS</td>\n",
       "      <td>APAF1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KEAP1-NRF2_signaling_pathway</th>\n",
       "      <td>KEAP1</td>\n",
       "      <td>NFE2L2</td>\n",
       "      <td>HMOX1</td>\n",
       "      <td>NQO1</td>\n",
       "      <td>GSTO2</td>\n",
       "      <td>GSTA5</td>\n",
       "      <td>GSTA1</td>\n",
       "      <td>GSTA2</td>\n",
       "      <td>GSTA3</td>\n",
       "      <td>GSTA4</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KITLG-KIT-PI3K_signaling_pathway</th>\n",
       "      <td>KITLG</td>\n",
       "      <td>KIT</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>RPS6KB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KITLG-KIT-RAS-ERK_signaling_pathway</th>\n",
       "      <td>KITLG</td>\n",
       "      <td>KIT</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MDM2-p21-Cell_cycle_G1-S</th>\n",
       "      <td>CDKN2A</td>\n",
       "      <td>MDM2</td>\n",
       "      <td>TP53</td>\n",
       "      <td>CDKN1A</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NOTCH_signaling_pathway</th>\n",
       "      <td>DLL1</td>\n",
       "      <td>DLL3</td>\n",
       "      <td>DLL4</td>\n",
       "      <td>JAG1</td>\n",
       "      <td>JAG2</td>\n",
       "      <td>NOTCH1</td>\n",
       "      <td>NOTCH2</td>\n",
       "      <td>NOTCH3</td>\n",
       "      <td>NOTCH4</td>\n",
       "      <td>HES1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p15-Cell_cycle_G1-S</th>\n",
       "      <td>MYC</td>\n",
       "      <td>MAX</td>\n",
       "      <td>ZBTB17</td>\n",
       "      <td>CDKN2B</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p16-Cell_cycle_G1-S</th>\n",
       "      <td>CDKN2A</td>\n",
       "      <td>CCND1</td>\n",
       "      <td>CCND2</td>\n",
       "      <td>CCND3</td>\n",
       "      <td>CDK4</td>\n",
       "      <td>CDK6</td>\n",
       "      <td>RB1</td>\n",
       "      <td>E2F1</td>\n",
       "      <td>E2F2</td>\n",
       "      <td>E2F3</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>p27-Cell_cycle_G1-S</th>\n",
       "      <td>SKP1</td>\n",
       "      <td>CUL1</td>\n",
       "      <td>RBX1</td>\n",
       "      <td>SKP2</td>\n",
       "      <td>CDKN1B</td>\n",
       "      <td>CCNA2</td>\n",
       "      <td>CCNA1</td>\n",
       "      <td>CCNE1</td>\n",
       "      <td>CCNE2</td>\n",
       "      <td>CDK2</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-PI3K_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-PLCG-CAMK_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>CALM1</td>\n",
       "      <td>CALM2</td>\n",
       "      <td>CALM3</td>\n",
       "      <td>CAMK1</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGF-PDGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>PDGFA</td>\n",
       "      <td>PDGFB</td>\n",
       "      <td>PDGFRA</td>\n",
       "      <td>PDGFRB</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTEN-PIP3-AKT_signaling_pathway</th>\n",
       "      <td>PTEN</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Telomerase_activity</th>\n",
       "      <td>TERC</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-PI3K_signaling_pathway</th>\n",
       "      <td>TGFB1</td>\n",
       "      <td>TGFB2</td>\n",
       "      <td>TGFB3</td>\n",
       "      <td>TGFBR2</td>\n",
       "      <td>TGFBR1</td>\n",
       "      <td>SMAD2</td>\n",
       "      <td>SMAD3</td>\n",
       "      <td>SMAD4</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-PLCG-PKC_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PIK3CA</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>AKT1</td>\n",
       "      <td>AKT2</td>\n",
       "      <td>AKT3</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGFA-EGFR-RAS-ERK_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>PLCG1</td>\n",
       "      <td>PLCG2</td>\n",
       "      <td>PRKCA</td>\n",
       "      <td>PRKCB</td>\n",
       "      <td>PRKCG</td>\n",
       "      <td>ELK1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TGF-beta_signaling_pathway</th>\n",
       "      <td>TGFA</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>GRB2</td>\n",
       "      <td>SOS1</td>\n",
       "      <td>SOS2</td>\n",
       "      <td>HRAS</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>NRAS</td>\n",
       "      <td>ARAF</td>\n",
       "      <td>BRAF</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WNT_signaling_pathway</th>\n",
       "      <td>WNT1</td>\n",
       "      <td>WNT2</td>\n",
       "      <td>WNT2B</td>\n",
       "      <td>WNT3</td>\n",
       "      <td>WNT3A</td>\n",
       "      <td>WNT4</td>\n",
       "      <td>WNT5A</td>\n",
       "      <td>WNT5B</td>\n",
       "      <td>WNT6</td>\n",
       "      <td>WNT7A</td>\n",
       "      <td>...</td>\n",
       "      <td>AXIN1</td>\n",
       "      <td>AXIN2</td>\n",
       "      <td>APC</td>\n",
       "      <td>CTNNB1</td>\n",
       "      <td>TCF7</td>\n",
       "      <td>TCF7L1</td>\n",
       "      <td>TCF7L2</td>\n",
       "      <td>LEF1</td>\n",
       "      <td>MYC</td>\n",
       "      <td>CCND1</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>40 rows × 46 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                            1       2       3        4   \\\n",
       "0                                                                         \n",
       "Androgen_receptor_signaling_pathway         AR    KLK3       0        0   \n",
       "Cytokine-Jak-STAT_signaling_pathway        IL2     IL3     IL4      IL5   \n",
       "DCC-apoptotic_pathway                    CASP3     DCC   CASP9    APPL1   \n",
       "EGF-EGFR-PI3K_signaling_pathway            EGF    EGFR  PIK3CA   PIK3CB   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway       EGF    EGFR   PLCG1    PLCG2   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway         EGF    EGFR    GRB2     SOS1   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway      EGF    EGFR    GRB2     SOS1   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway      EGF    EGFR    GRB2     SOS1   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway        EGF   ERBB2    EGFR     GRB2   \n",
       "EGF-Jak-STAT_signaling_pathway             EGF    EGFR    JAK1    STAT1   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF1    FGF2    FGF3     FGF4   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF1    FGF2    FGF3     FGF4   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway   FLT3LG    FLT3    GRB2     SOS1   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway  FLT3LG    FLT3    GRB2     SOS1   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway     FLT3LG    FLT3  STAT5A   STAT5B   \n",
       "Hedgehog_signaling_pathway                 SHH   PTCH1     SMO     SUFU   \n",
       "HGF-MET-PI3K_signaling_pathway             HGF     MET    GAB1   PIK3CA   \n",
       "HGF-MET-RAS-ERK_signaling_pathway          HGF     MET    GRB2     SOS1   \n",
       "HIF-1_signaling_pathway                  HIF1A    ARNT  SLC2A1    VEGFA   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         IGF1    IGF2   IGF1R     GRB2   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       IGF2   IGF1R  PIK3CA   PIK3CB   \n",
       "Intrinsic_apoptotic_pathway             PMAIP1    BBC3     BAD  BCL2L11   \n",
       "KEAP1-NRF2_signaling_pathway             KEAP1  NFE2L2   HMOX1     NQO1   \n",
       "KITLG-KIT-PI3K_signaling_pathway         KITLG     KIT  PIK3CA   PIK3CB   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway      KITLG     KIT    GRB2     SOS1   \n",
       "MDM2-p21-Cell_cycle_G1-S                CDKN2A    MDM2    TP53   CDKN1A   \n",
       "NOTCH_signaling_pathway                   DLL1    DLL3    DLL4     JAG1   \n",
       "p15-Cell_cycle_G1-S                        MYC     MAX  ZBTB17   CDKN2B   \n",
       "p16-Cell_cycle_G1-S                     CDKN2A   CCND1   CCND2    CCND3   \n",
       "p27-Cell_cycle_G1-S                       SKP1    CUL1    RBX1     SKP2   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway        PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway     PDGFA   PDGFB  PDGFRA   PDGFRB   \n",
       "PTEN-PIP3-AKT_signaling_pathway           PTEN    AKT1    AKT2     AKT3   \n",
       "Telomerase_activity                       TERC       0       0        0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway         TGFB1   TGFB2   TGFB3   TGFBR2   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      TGFA    EGFR  PIK3CA   PIK3CB   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway       TGFA    EGFR   PLCG1    PLCG2   \n",
       "TGF-beta_signaling_pathway                TGFA    EGFR    GRB2     SOS1   \n",
       "WNT_signaling_pathway                     WNT1    WNT2   WNT2B     WNT3   \n",
       "\n",
       "                                            5       6       7       8   \\\n",
       "0                                                                        \n",
       "Androgen_receptor_signaling_pathway          0       0       0       0   \n",
       "Cytokine-Jak-STAT_signaling_pathway        IL6     IL7   IL12A   IL12B   \n",
       "DCC-apoptotic_pathway                        0       0       0       0   \n",
       "EGF-EGFR-PI3K_signaling_pathway         PIK3CD    AKT1    AKT2    AKT3   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway     CALM1   CALM2   CALM3   CAMK1   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       SOS1    SOS2    HRAS    KRAS   \n",
       "EGF-Jak-STAT_signaling_pathway           STAT3  STAT5A  STAT5B       0   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF5    FGF6    FGF7    FGF8   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF5    FGF6    FGF7    FGF8   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     SOS2    HRAS    KRAS    NRAS   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway    SOS2    HRAS    KRAS    NRAS   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway          0       0       0       0   \n",
       "Hedgehog_signaling_pathway                GLI1    GLI2    GLI3    GLI1   \n",
       "HGF-MET-PI3K_signaling_pathway          PIK3CB  PIK3CD    AKT1    AKT2   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         SOS2    HRAS    KRAS    NRAS   \n",
       "HIF-1_signaling_pathway                  TGFB1   TGFB2   TGFB3   PDGFB   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         SOS1    SOS2    HRAS    KRAS   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway     PIK3CD    AKT1    AKT2    AKT3   \n",
       "Intrinsic_apoptotic_pathway               BCL2  BCL2L1     BAX    BAK1   \n",
       "KEAP1-NRF2_signaling_pathway             GSTO2   GSTA5   GSTA1   GSTA2   \n",
       "KITLG-KIT-PI3K_signaling_pathway        PIK3CD    AKT1    AKT2    AKT3   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       SOS2    HRAS    KRAS    NRAS   \n",
       "MDM2-p21-Cell_cycle_G1-S                 CCND1   CCND2   CCND3    CDK4   \n",
       "NOTCH_signaling_pathway                   JAG2  NOTCH1  NOTCH2  NOTCH3   \n",
       "p15-Cell_cycle_G1-S                      CCND1   CCND2   CCND3    CDK4   \n",
       "p16-Cell_cycle_G1-S                       CDK4    CDK6     RB1    E2F1   \n",
       "p27-Cell_cycle_G1-S                     CDKN1B   CCNA2   CCNA1   CCNE1   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway       PIK3CA  PIK3CB  PIK3CD    AKT1   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   PLCG1   PLCG2   CALM1   CALM2   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      GRB2    SOS1    SOS2    HRAS   \n",
       "PTEN-PIP3-AKT_signaling_pathway              0       0       0       0   \n",
       "Telomerase_activity                          0       0       0       0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway        TGFBR1   SMAD2   SMAD3   SMAD4   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway    PIK3CD    AKT1    AKT2    AKT3   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway      PRKCA   PRKCB   PRKCG    ELK1   \n",
       "TGF-beta_signaling_pathway                SOS2    HRAS    KRAS    NRAS   \n",
       "WNT_signaling_pathway                    WNT3A    WNT4   WNT5A   WNT5B   \n",
       "\n",
       "                                            9        10  ...     37     38  \\\n",
       "0                                                        ...                 \n",
       "Androgen_receptor_signaling_pathway          0        0  ...      0      0   \n",
       "Cytokine-Jak-STAT_signaling_pathway       IL13     IL15  ...   JAK3  STAT1   \n",
       "DCC-apoptotic_pathway                        0        0  ...      0      0   \n",
       "EGF-EGFR-PI3K_signaling_pathway            BAD        0  ...      0      0   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway    CAMK1D   CAMK1G  ...      0      0   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway        ARAF     BRAF  ...      0      0   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway   RALGDS     RALA  ...      0      0   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway   RASSF1   RASSF5  ...      0      0   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway       NRAS     ARAF  ...      0      0   \n",
       "EGF-Jak-STAT_signaling_pathway               0        0  ...      0      0   \n",
       "FGF-FGFR-PI3K_signaling_pathway           FGF9    FGF10  ...      0      0   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway        FGF9    FGF10  ...      0      0   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway     ARAF     BRAF  ...      0      0   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway  PIK3CA   PIK3CB  ...      0      0   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway          0        0  ...      0      0   \n",
       "Hedgehog_signaling_pathway               PTCH1    PTCH2  ...      0      0   \n",
       "HGF-MET-PI3K_signaling_pathway            AKT3      BAD  ...      0      0   \n",
       "HGF-MET-RAS-ERK_signaling_pathway         ARAF     BRAF  ...      0      0   \n",
       "HIF-1_signaling_pathway                   TGFA        0  ...      0      0   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway         NRAS     ARAF  ...      0      0   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway       MTOR  RPS6KB1  ...      0      0   \n",
       "Intrinsic_apoptotic_pathway               CYCS    APAF1  ...      0      0   \n",
       "KEAP1-NRF2_signaling_pathway             GSTA3    GSTA4  ...      0      0   \n",
       "KITLG-KIT-PI3K_signaling_pathway          MTOR  RPS6KB1  ...      0      0   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway       ARAF     BRAF  ...      0      0   \n",
       "MDM2-p21-Cell_cycle_G1-S                  CDK6      RB1  ...      0      0   \n",
       "NOTCH_signaling_pathway                 NOTCH4     HES1  ...      0      0   \n",
       "p15-Cell_cycle_G1-S                       CDK6      RB1  ...      0      0   \n",
       "p16-Cell_cycle_G1-S                       E2F2     E2F3  ...      0      0   \n",
       "p27-Cell_cycle_G1-S                      CCNE2     CDK2  ...      0      0   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway         AKT2     AKT3  ...      0      0   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway   CALM3    CAMK1  ...      0      0   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway      KRAS     NRAS  ...      0      0   \n",
       "PTEN-PIP3-AKT_signaling_pathway              0        0  ...      0      0   \n",
       "Telomerase_activity                          0        0  ...      0      0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway             0        0  ...      0      0   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway      MTOR        0  ...      0      0   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway          0        0  ...      0      0   \n",
       "TGF-beta_signaling_pathway                ARAF     BRAF  ...      0      0   \n",
       "WNT_signaling_pathway                     WNT6    WNT7A  ...  AXIN1  AXIN2   \n",
       "\n",
       "                                           39      40     41      42      43  \\\n",
       "0                                                                              \n",
       "Androgen_receptor_signaling_pathway         0       0      0       0       0   \n",
       "Cytokine-Jak-STAT_signaling_pathway     STAT2   STAT3  STAT4  STAT5A  STAT5B   \n",
       "DCC-apoptotic_pathway                       0       0      0       0       0   \n",
       "EGF-EGFR-PI3K_signaling_pathway             0       0      0       0       0   \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway        0       0      0       0       0   \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway          0       0      0       0       0   \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway       0       0      0       0       0   \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway       0       0      0       0       0   \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "EGF-Jak-STAT_signaling_pathway              0       0      0       0       0   \n",
       "FGF-FGFR-PI3K_signaling_pathway             0       0      0       0       0   \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway          0       0      0       0       0   \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway       0       0      0       0       0   \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway      0       0      0       0       0   \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway         0       0      0       0       0   \n",
       "Hedgehog_signaling_pathway                  0       0      0       0       0   \n",
       "HGF-MET-PI3K_signaling_pathway              0       0      0       0       0   \n",
       "HGF-MET-RAS-ERK_signaling_pathway           0       0      0       0       0   \n",
       "HIF-1_signaling_pathway                     0       0      0       0       0   \n",
       "IGF2-IGF1R-PI3K_signaling_pathway           0       0      0       0       0   \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "Intrinsic_apoptotic_pathway                 0       0      0       0       0   \n",
       "KEAP1-NRF2_signaling_pathway                0       0      0       0       0   \n",
       "KITLG-KIT-PI3K_signaling_pathway            0       0      0       0       0   \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "MDM2-p21-Cell_cycle_G1-S                    0       0      0       0       0   \n",
       "NOTCH_signaling_pathway                     0       0      0       0       0   \n",
       "p15-Cell_cycle_G1-S                         0       0      0       0       0   \n",
       "p16-Cell_cycle_G1-S                         0       0      0       0       0   \n",
       "p27-Cell_cycle_G1-S                         0       0      0       0       0   \n",
       "PDGF-PDGFR-PI3K_signaling_pathway           0       0      0       0       0   \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway      0       0      0       0       0   \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway        0       0      0       0       0   \n",
       "PTEN-PIP3-AKT_signaling_pathway             0       0      0       0       0   \n",
       "Telomerase_activity                         0       0      0       0       0   \n",
       "TGFA-EGFR-PI3K_signaling_pathway            0       0      0       0       0   \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway        0       0      0       0       0   \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway         0       0      0       0       0   \n",
       "TGF-beta_signaling_pathway                  0       0      0       0       0   \n",
       "WNT_signaling_pathway                     APC  CTNNB1   TCF7  TCF7L1  TCF7L2   \n",
       "\n",
       "                                           44    45     46  \n",
       "0                                                           \n",
       "Androgen_receptor_signaling_pathway         0     0      0  \n",
       "Cytokine-Jak-STAT_signaling_pathway     STAT6  PIM1      0  \n",
       "DCC-apoptotic_pathway                       0     0      0  \n",
       "EGF-EGFR-PI3K_signaling_pathway             0     0      0  \n",
       "EGF-EGFR-PLCG-CAMK_signaling_pathway        0     0      0  \n",
       "EGF-EGFR-RAS-ERK_signaling_pathway          0     0      0  \n",
       "EGF-EGFR-RAS-RalGDS_signaling_pathway       0     0      0  \n",
       "EGF-EGFR-RAS-RASSF1_signaling_pathway       0     0      0  \n",
       "EGF-ERBB2-RAS-ERK_signaling_pathway         0     0      0  \n",
       "EGF-Jak-STAT_signaling_pathway              0     0      0  \n",
       "FGF-FGFR-PI3K_signaling_pathway             0     0      0  \n",
       "FGF-FGFR-RAS-ERK_signaling_pathway          0     0      0  \n",
       "FLT3LG-FLT3-RAS-ERK_signaling_pathway       0     0      0  \n",
       "FLT3LG-FLT3-RAS-PI3K_signaling_pathway      0     0      0  \n",
       "FLT3LG-FLT3-STAT5_signaling_pathway         0     0      0  \n",
       "Hedgehog_signaling_pathway                  0     0      0  \n",
       "HGF-MET-PI3K_signaling_pathway              0     0      0  \n",
       "HGF-MET-RAS-ERK_signaling_pathway           0     0      0  \n",
       "HIF-1_signaling_pathway                     0     0      0  \n",
       "IGF2-IGF1R-PI3K_signaling_pathway           0     0      0  \n",
       "IGF-IGF1R-RAS-ERK_signaling_pathway         0     0      0  \n",
       "Intrinsic_apoptotic_pathway                 0     0      0  \n",
       "KEAP1-NRF2_signaling_pathway                0     0      0  \n",
       "KITLG-KIT-PI3K_signaling_pathway            0     0      0  \n",
       "KITLG-KIT-RAS-ERK_signaling_pathway         0     0      0  \n",
       "MDM2-p21-Cell_cycle_G1-S                    0     0      0  \n",
       "NOTCH_signaling_pathway                     0     0      0  \n",
       "p15-Cell_cycle_G1-S                         0     0      0  \n",
       "p16-Cell_cycle_G1-S                         0     0      0  \n",
       "p27-Cell_cycle_G1-S                         0     0      0  \n",
       "PDGF-PDGFR-PI3K_signaling_pathway           0     0      0  \n",
       "PDGF-PDGFR-PLCG-CAMK_signaling_pathway      0     0      0  \n",
       "PDGF-PDGFR-RAS-ERK_signaling_pathway        0     0      0  \n",
       "PTEN-PIP3-AKT_signaling_pathway             0     0      0  \n",
       "Telomerase_activity                         0     0      0  \n",
       "TGFA-EGFR-PI3K_signaling_pathway            0     0      0  \n",
       "TGFA-EGFR-PLCG-PKC_signaling_pathway        0     0      0  \n",
       "TGFA-EGFR-RAS-ERK_signaling_pathway         0     0      0  \n",
       "TGF-beta_signaling_pathway                  0     0      0  \n",
       "WNT_signaling_pathway                    LEF1   MYC  CCND1  \n",
       "\n",
       "[40 rows x 46 columns]"
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pathways=pathways.drop(pathways.index[40])\n",
    "pathways"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "id": "7850cea7",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[['AR',\n",
       "  'KLK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['IL2',\n",
       "  'IL3',\n",
       "  'IL4',\n",
       "  'IL5',\n",
       "  'IL6',\n",
       "  'IL7',\n",
       "  'IL12A',\n",
       "  'IL12B',\n",
       "  'IL13',\n",
       "  'IL15',\n",
       "  'IL23A',\n",
       "  'EPO',\n",
       "  'IFNA1',\n",
       "  'IFNG',\n",
       "  'IL2RA',\n",
       "  'IL2RB',\n",
       "  'IL2RG',\n",
       "  'IL3RA',\n",
       "  'IL4R',\n",
       "  'CSF2RB',\n",
       "  'IL5RA',\n",
       "  'IL6R',\n",
       "  'IL6ST',\n",
       "  'IL7R',\n",
       "  'IL12RB1',\n",
       "  'IL12RB2',\n",
       "  'IL13RA1',\n",
       "  'IL15RA',\n",
       "  'IL23R',\n",
       "  'EPOR',\n",
       "  'IFNAR1',\n",
       "  'IFNAR2',\n",
       "  'IFNGR1',\n",
       "  'IFNGR2',\n",
       "  'JAK1',\n",
       "  'JAK2',\n",
       "  'JAK3',\n",
       "  'STAT1',\n",
       "  'STAT2',\n",
       "  'STAT3',\n",
       "  'STAT4',\n",
       "  'STAT5A',\n",
       "  'STAT5B',\n",
       "  'STAT6',\n",
       "  'PIM1',\n",
       "  0],\n",
       " ['CASP3',\n",
       "  'DCC',\n",
       "  'CASP9',\n",
       "  'APPL1',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'EGFR',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'BAD',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'EGFR',\n",
       "  'PLCG1',\n",
       "  'PLCG2',\n",
       "  'CALM1',\n",
       "  'CALM2',\n",
       "  'CALM3',\n",
       "  'CAMK1',\n",
       "  'CAMK1D',\n",
       "  'CAMK1G',\n",
       "  'CAMK2A',\n",
       "  'CAMK2B',\n",
       "  'CAMK2D',\n",
       "  'CAMK2G',\n",
       "  'CAMK4',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'EGFR',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  'CCND1',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'EGFR',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'RALGDS',\n",
       "  'RALA',\n",
       "  'RALB',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'EGFR',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'RASSF1',\n",
       "  'RASSF5',\n",
       "  'STK4',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'ERBB2',\n",
       "  'EGFR',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['EGF',\n",
       "  'EGFR',\n",
       "  'JAK1',\n",
       "  'STAT1',\n",
       "  'STAT3',\n",
       "  'STAT5A',\n",
       "  'STAT5B',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['FGF1',\n",
       "  'FGF2',\n",
       "  'FGF3',\n",
       "  'FGF4',\n",
       "  'FGF5',\n",
       "  'FGF6',\n",
       "  'FGF7',\n",
       "  'FGF8',\n",
       "  'FGF9',\n",
       "  'FGF10',\n",
       "  'FGF16',\n",
       "  'FGF17',\n",
       "  'FGF18',\n",
       "  'FGF19',\n",
       "  'FGF20',\n",
       "  'FGF21',\n",
       "  'FGF22',\n",
       "  'FGF23',\n",
       "  'FGFR1',\n",
       "  'FGFR2',\n",
       "  'FGFR3',\n",
       "  'FGFR4',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'MTOR',\n",
       "  'RPS6KB1',\n",
       "  'RPS6KB2',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['FGF1',\n",
       "  'FGF2',\n",
       "  'FGF3',\n",
       "  'FGF4',\n",
       "  'FGF5',\n",
       "  'FGF6',\n",
       "  'FGF7',\n",
       "  'FGF8',\n",
       "  'FGF9',\n",
       "  'FGF10',\n",
       "  'FGF16',\n",
       "  'FGF17',\n",
       "  'FGF18',\n",
       "  'FGF19',\n",
       "  'FGF20',\n",
       "  'FGF21',\n",
       "  'FGF22',\n",
       "  'FGF23',\n",
       "  'FGFR1',\n",
       "  'FGFR2',\n",
       "  'FGFR3',\n",
       "  'FGFR4',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['FLT3LG',\n",
       "  'FLT3',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['FLT3LG',\n",
       "  'FLT3',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'MTOR',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['FLT3LG',\n",
       "  'FLT3',\n",
       "  'STAT5A',\n",
       "  'STAT5B',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['SHH',\n",
       "  'PTCH1',\n",
       "  'SMO',\n",
       "  'SUFU',\n",
       "  'GLI1',\n",
       "  'GLI2',\n",
       "  'GLI3',\n",
       "  'GLI1',\n",
       "  'PTCH1',\n",
       "  'PTCH2',\n",
       "  'HHIP',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['HGF',\n",
       "  'MET',\n",
       "  'GAB1',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'BAD',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['HGF',\n",
       "  'MET',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['HIF1A',\n",
       "  'ARNT',\n",
       "  'SLC2A1',\n",
       "  'VEGFA',\n",
       "  'TGFB1',\n",
       "  'TGFB2',\n",
       "  'TGFB3',\n",
       "  'PDGFB',\n",
       "  'TGFA',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['IGF1',\n",
       "  'IGF2',\n",
       "  'IGF1R',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['IGF2',\n",
       "  'IGF1R',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'MTOR',\n",
       "  'RPS6KB1',\n",
       "  'RPS6KB2',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['PMAIP1',\n",
       "  'BBC3',\n",
       "  'BAD',\n",
       "  'BCL2L11',\n",
       "  'BCL2',\n",
       "  'BCL2L1',\n",
       "  'BAX',\n",
       "  'BAK1',\n",
       "  'CYCS',\n",
       "  'APAF1',\n",
       "  'CASP9',\n",
       "  'CASP3',\n",
       "  'CASP7',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['KEAP1',\n",
       "  'NFE2L2',\n",
       "  'HMOX1',\n",
       "  'NQO1',\n",
       "  'GSTO2',\n",
       "  'GSTA5',\n",
       "  'GSTA1',\n",
       "  'GSTA2',\n",
       "  'GSTA3',\n",
       "  'GSTA4',\n",
       "  'GSTM1',\n",
       "  'GSTM2',\n",
       "  'GSTM3',\n",
       "  'GSTM4',\n",
       "  'GSTM5',\n",
       "  'GSTP1',\n",
       "  'GSTT1',\n",
       "  'GSTT2',\n",
       "  'MGST1',\n",
       "  'MGST2',\n",
       "  'MGST3',\n",
       "  'GSTT2B',\n",
       "  'GSTO1',\n",
       "  'TXNRD1',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['KITLG',\n",
       "  'KIT',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'MTOR',\n",
       "  'RPS6KB1',\n",
       "  'RPS6KB2',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['KITLG',\n",
       "  'KIT',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['CDKN2A',\n",
       "  'MDM2',\n",
       "  'TP53',\n",
       "  'CDKN1A',\n",
       "  'CCND1',\n",
       "  'CCND2',\n",
       "  'CCND3',\n",
       "  'CDK4',\n",
       "  'CDK6',\n",
       "  'RB1',\n",
       "  'E2F1',\n",
       "  'E2F2',\n",
       "  'E2F3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['DLL1',\n",
       "  'DLL3',\n",
       "  'DLL4',\n",
       "  'JAG1',\n",
       "  'JAG2',\n",
       "  'NOTCH1',\n",
       "  'NOTCH2',\n",
       "  'NOTCH3',\n",
       "  'NOTCH4',\n",
       "  'HES1',\n",
       "  'HEY1',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['MYC',\n",
       "  'MAX',\n",
       "  'ZBTB17',\n",
       "  'CDKN2B',\n",
       "  'CCND1',\n",
       "  'CCND2',\n",
       "  'CCND3',\n",
       "  'CDK4',\n",
       "  'CDK6',\n",
       "  'RB1',\n",
       "  'E2F1',\n",
       "  'E2F2',\n",
       "  'E2F3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['CDKN2A',\n",
       "  'CCND1',\n",
       "  'CCND2',\n",
       "  'CCND3',\n",
       "  'CDK4',\n",
       "  'CDK6',\n",
       "  'RB1',\n",
       "  'E2F1',\n",
       "  'E2F2',\n",
       "  'E2F3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['SKP1',\n",
       "  'CUL1',\n",
       "  'RBX1',\n",
       "  'SKP2',\n",
       "  'CDKN1B',\n",
       "  'CCNA2',\n",
       "  'CCNA1',\n",
       "  'CCNE1',\n",
       "  'CCNE2',\n",
       "  'CDK2',\n",
       "  'RB1',\n",
       "  'E2F1',\n",
       "  'E2F2',\n",
       "  'E2F3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['PDGFA',\n",
       "  'PDGFB',\n",
       "  'PDGFRA',\n",
       "  'PDGFRB',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'MTOR',\n",
       "  'RPS6KB1',\n",
       "  'RPS6KB2',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['PDGFA',\n",
       "  'PDGFB',\n",
       "  'PDGFRA',\n",
       "  'PDGFRB',\n",
       "  'PLCG1',\n",
       "  'PLCG2',\n",
       "  'CALM1',\n",
       "  'CALM2',\n",
       "  'CALM3',\n",
       "  'CAMK1',\n",
       "  'CAMK1D',\n",
       "  'CAMK1G',\n",
       "  'CAMK2A',\n",
       "  'CAMK2B',\n",
       "  'CAMK2D',\n",
       "  'CAMK2G',\n",
       "  'CAMK4',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['PDGFA',\n",
       "  'PDGFB',\n",
       "  'PDGFRA',\n",
       "  'PDGFRB',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['PTEN',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['TERC',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['TGFB1',\n",
       "  'TGFB2',\n",
       "  'TGFB3',\n",
       "  'TGFBR2',\n",
       "  'TGFBR1',\n",
       "  'SMAD2',\n",
       "  'SMAD3',\n",
       "  'SMAD4',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['TGFA',\n",
       "  'EGFR',\n",
       "  'PIK3CA',\n",
       "  'PIK3CB',\n",
       "  'PIK3CD',\n",
       "  'AKT1',\n",
       "  'AKT2',\n",
       "  'AKT3',\n",
       "  'MTOR',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['TGFA',\n",
       "  'EGFR',\n",
       "  'PLCG1',\n",
       "  'PLCG2',\n",
       "  'PRKCA',\n",
       "  'PRKCB',\n",
       "  'PRKCG',\n",
       "  'ELK1',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['TGFA',\n",
       "  'EGFR',\n",
       "  'GRB2',\n",
       "  'SOS1',\n",
       "  'SOS2',\n",
       "  'HRAS',\n",
       "  'KRAS',\n",
       "  'NRAS',\n",
       "  'ARAF',\n",
       "  'BRAF',\n",
       "  'RAF1',\n",
       "  'MAP2K1',\n",
       "  'MAP2K2',\n",
       "  'MAPK1',\n",
       "  'MAPK3',\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0,\n",
       "  0],\n",
       " ['WNT1',\n",
       "  'WNT2',\n",
       "  'WNT2B',\n",
       "  'WNT3',\n",
       "  'WNT3A',\n",
       "  'WNT4',\n",
       "  'WNT5A',\n",
       "  'WNT5B',\n",
       "  'WNT6',\n",
       "  'WNT7A',\n",
       "  'WNT7B',\n",
       "  'WNT8A',\n",
       "  'WNT8B',\n",
       "  'WNT9A',\n",
       "  'WNT9B',\n",
       "  'WNT10A',\n",
       "  'WNT10B',\n",
       "  'WNT16',\n",
       "  'FZD1',\n",
       "  'FZD2',\n",
       "  'FZD3',\n",
       "  'FZD4',\n",
       "  'FZD5',\n",
       "  'FZD6',\n",
       "  'FZD7',\n",
       "  'FZD8',\n",
       "  'FZD9',\n",
       "  'FZD10',\n",
       "  'LRP5',\n",
       "  'LRP6',\n",
       "  'DVL1',\n",
       "  'DVL2',\n",
       "  'DVL3',\n",
       "  'FRAT1',\n",
       "  'FRAT2',\n",
       "  'GSK3B',\n",
       "  'AXIN1',\n",
       "  'AXIN2',\n",
       "  'APC',\n",
       "  'CTNNB1',\n",
       "  'TCF7',\n",
       "  'TCF7L1',\n",
       "  'TCF7L2',\n",
       "  'LEF1',\n",
       "  'MYC',\n",
       "  'CCND1']]"
      ]
     },
     "execution_count": 5,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pathway_list=np.array(pathways).tolist()\n",
    "pathway_list"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "d57c6d4b",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[0, 'IL4', 'CAMK2B', 'PRKCA', 'TERC', 'IL2', 'PIK3CA', 'CCND1', 'CDK6', 'CCNE2', 'TCF7', 'IL15RA', 'IL5', 'IL13RA1', 'WNT5A', 'KEAP1', 'FZD3', 'LEF1', 'IFNGR2', 'FZD4', 'PIK3CB', 'IL12RB2', 'GSTM3', 'STAT3', 'VEGFA', 'CCNA1', 'HES1', 'NOTCH3', 'IFNG', 'HHIP', 'RALGDS', 'HEY1', 'FGF17', 'AKT2', 'STAT6', 'CAMK4', 'CDKN2B', 'FGF4', 'PLCG1', 'RAF1', 'RPS6KB1', 'E2F2', 'SUFU', 'MET', 'GSTA4', 'GSTA1', 'KITLG', 'PDGFA', 'FLT3LG', 'TGFB3', 'GSTM2', 'EPO', 'MGST3', 'FZD7', 'FGF20', 'BAX', 'IL23A', 'JAK2', 'IL4R', 'CALM2', 'IL7', 'IL15', 'CALM3', 'RALA', 'PDGFB', 'IL13', 'FGFR3', 'NQO1', 'DLL3', 'FZD2', 'IL6', 'IFNAR2', 'CDKN1A', 'RBX1', 'RASSF1', 'FGF6', 'IL2RA', 'ERBB2', 'WNT2', 'AKT1', 'IL6ST', 'CAMK2G', 'RPS6KB2', 'SKP2', 'TXNRD1', 'CTNNB1', 'AXIN2', 'SHH', 'CDKN2A', 'JAG1', 'JAK3', 'NOTCH2', 'AR', 'IL2RB', 'BCL2L11', 'WNT8A', 'PRKCG', 'CASP3', 'CCND3', 'STAT1', 'TP53', 'DVL1', 'MAPK3', 'CAMK2A', 'TGFB1', 'IL12B', 'TCF7L2', 'PTEN', 'GSTT2B', 'IL7R', 'GSTO1', 'IL5RA', 'IGF2', 'MAX', 'BCL2L1', 'FGF19', 'PMAIP1', 'CDK2', 'FZD1', 'PTCH1', 'WNT3', 'NFE2L2', 'WNT6', 'FZD5', 'MGST1', 'JAK1', 'MAP2K1', 'DCC', 'FGF18', 'IL23R', 'WNT3A', 'EGF', 'FGF8', 'SMO', 'GSTM1', 'WNT7B', 'APPL1', 'E2F3', 'SOS1', 'APC', 'TGFBR1', 'WNT8B', 'WNT16', 'GLI3', 'CASP7', 'DVL2', 'CAMK2D', 'CAMK1D', 'FGF16', 'GSTA2', 'PDGFRA', 'BAK1', 'MYC', 'WNT5B', 'PDGFRB', 'MDM2', 'FGF3', 'IFNAR1', 'IL12RB1', 'STAT4', 'MAPK1', 'CASP9', 'AKT3', 'BRAF', 'NOTCH1', 'BCL2', 'STAT2', 'FGF9', 'CDKN1B', 'WNT10B', 'NOTCH4', 'IL3', 'IL6R', 'IGF1R', 'KIT', 'SMAD4', 'BBC3', 'NRAS', 'MTOR', 'GLI2', 'SMAD2', 'DVL3', 'RASSF5', 'SLC2A1', 'WNT2B', 'GSTP1', 'FZD9', 'IL3RA', 'FGF23', 'FZD8', 'GSTM5', 'STAT5A', 'WNT9A', 'HRAS', 'STK4', 'FLT3', 'APAF1', 'JAG2', 'WNT7A', 'GAB1', 'FRAT2', 'EGFR', 'WNT10A', 'CDK4', 'LRP5', 'MAP2K2', 'E2F1', 'MGST2', 'ARNT', 'EPOR', 'CALM1', 'GSTA3', 'GSTT2', 'ZBTB17', 'FZD10', 'FGFR4', 'FGFR1', 'CCND2', 'FZD6', 'CCNA2', 'PIK3CD', 'SOS2', 'TGFA', 'DLL1', 'GSTA5', 'HMOX1', 'RALB', 'PRKCB', 'FGF5', 'HIF1A', 'CAMK1', 'IL12A', 'RB1', 'ELK1', 'IFNGR1', 'FGF22', 'BAD', 'PIM1', 'GLI1', 'SKP1', 'GSK3B', 'FGF21', 'FGF1', 'STAT5B', 'HGF', 'TGFB2', 'CUL1', 'LRP6', 'CAMK1G', 'CCNE1', 'IL2RG', 'PLCG2', 'GRB2', 'PTCH2', 'IGF1', 'DLL4', 'ARAF', 'GSTO2', 'TGFBR2', 'CYCS', 'FRAT1', 'FGF2', 'GSTT1', 'WNT1', 'WNT9B', 'AXIN1', 'FGFR2', 'SMAD3', 'GSTM4', 'KLK3', 'TCF7L1', 'FGF10', 'WNT4', 'KRAS', 'IFNA1', 'CSF2RB', 'FGF7']\n"
     ]
    }
   ],
   "source": [
    "s =set()\n",
    "for item in pathway_list:\n",
    "    for i in item:\n",
    "        s.add(i)\n",
    "\n",
    "s=list(s)\n",
    "print(s)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "bc9c51c7",
   "metadata": {},
   "outputs": [],
   "source": [
    "s.remove(0)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "id": "eb7c3aac",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "276"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(s)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "7426d4fe",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['IL4',\n",
       " 'CAMK2B',\n",
       " 'PRKCA',\n",
       " 'TERC',\n",
       " 'IL2',\n",
       " 'PIK3CA',\n",
       " 'CCND1',\n",
       " 'CDK6',\n",
       " 'CCNE2',\n",
       " 'TCF7',\n",
       " 'IL15RA',\n",
       " 'IL5',\n",
       " 'IL13RA1',\n",
       " 'WNT5A',\n",
       " 'KEAP1',\n",
       " 'FZD3',\n",
       " 'LEF1',\n",
       " 'IFNGR2',\n",
       " 'FZD4',\n",
       " 'PIK3CB',\n",
       " 'IL12RB2',\n",
       " 'GSTM3',\n",
       " 'STAT3',\n",
       " 'VEGFA',\n",
       " 'CCNA1',\n",
       " 'HES1',\n",
       " 'NOTCH3',\n",
       " 'IFNG',\n",
       " 'HHIP',\n",
       " 'RALGDS',\n",
       " 'HEY1',\n",
       " 'FGF17',\n",
       " 'AKT2',\n",
       " 'STAT6',\n",
       " 'CAMK4',\n",
       " 'CDKN2B',\n",
       " 'FGF4',\n",
       " 'PLCG1',\n",
       " 'RAF1',\n",
       " 'RPS6KB1',\n",
       " 'E2F2',\n",
       " 'SUFU',\n",
       " 'MET',\n",
       " 'GSTA4',\n",
       " 'GSTA1',\n",
       " 'KITLG',\n",
       " 'PDGFA',\n",
       " 'FLT3LG',\n",
       " 'TGFB3',\n",
       " 'GSTM2',\n",
       " 'EPO',\n",
       " 'MGST3',\n",
       " 'FZD7',\n",
       " 'FGF20',\n",
       " 'BAX',\n",
       " 'IL23A',\n",
       " 'JAK2',\n",
       " 'IL4R',\n",
       " 'CALM2',\n",
       " 'IL7',\n",
       " 'IL15',\n",
       " 'CALM3',\n",
       " 'RALA',\n",
       " 'PDGFB',\n",
       " 'IL13',\n",
       " 'FGFR3',\n",
       " 'NQO1',\n",
       " 'DLL3',\n",
       " 'FZD2',\n",
       " 'IL6',\n",
       " 'IFNAR2',\n",
       " 'CDKN1A',\n",
       " 'RBX1',\n",
       " 'RASSF1',\n",
       " 'FGF6',\n",
       " 'IL2RA',\n",
       " 'ERBB2',\n",
       " 'WNT2',\n",
       " 'AKT1',\n",
       " 'IL6ST',\n",
       " 'CAMK2G',\n",
       " 'RPS6KB2',\n",
       " 'SKP2',\n",
       " 'TXNRD1',\n",
       " 'CTNNB1',\n",
       " 'AXIN2',\n",
       " 'SHH',\n",
       " 'CDKN2A',\n",
       " 'JAG1',\n",
       " 'JAK3',\n",
       " 'NOTCH2',\n",
       " 'AR',\n",
       " 'IL2RB',\n",
       " 'BCL2L11',\n",
       " 'WNT8A',\n",
       " 'PRKCG',\n",
       " 'CASP3',\n",
       " 'CCND3',\n",
       " 'STAT1',\n",
       " 'TP53',\n",
       " 'DVL1',\n",
       " 'MAPK3',\n",
       " 'CAMK2A',\n",
       " 'TGFB1',\n",
       " 'IL12B',\n",
       " 'TCF7L2',\n",
       " 'PTEN',\n",
       " 'GSTT2B',\n",
       " 'IL7R',\n",
       " 'GSTO1',\n",
       " 'IL5RA',\n",
       " 'IGF2',\n",
       " 'MAX',\n",
       " 'BCL2L1',\n",
       " 'FGF19',\n",
       " 'PMAIP1',\n",
       " 'CDK2',\n",
       " 'FZD1',\n",
       " 'PTCH1',\n",
       " 'WNT3',\n",
       " 'NFE2L2',\n",
       " 'WNT6',\n",
       " 'FZD5',\n",
       " 'MGST1',\n",
       " 'JAK1',\n",
       " 'MAP2K1',\n",
       " 'DCC',\n",
       " 'FGF18',\n",
       " 'IL23R',\n",
       " 'WNT3A',\n",
       " 'EGF',\n",
       " 'FGF8',\n",
       " 'SMO',\n",
       " 'GSTM1',\n",
       " 'WNT7B',\n",
       " 'APPL1',\n",
       " 'E2F3',\n",
       " 'SOS1',\n",
       " 'APC',\n",
       " 'TGFBR1',\n",
       " 'WNT8B',\n",
       " 'WNT16',\n",
       " 'GLI3',\n",
       " 'CASP7',\n",
       " 'DVL2',\n",
       " 'CAMK2D',\n",
       " 'CAMK1D',\n",
       " 'FGF16',\n",
       " 'GSTA2',\n",
       " 'PDGFRA',\n",
       " 'BAK1',\n",
       " 'MYC',\n",
       " 'WNT5B',\n",
       " 'PDGFRB',\n",
       " 'MDM2',\n",
       " 'FGF3',\n",
       " 'IFNAR1',\n",
       " 'IL12RB1',\n",
       " 'STAT4',\n",
       " 'MAPK1',\n",
       " 'CASP9',\n",
       " 'AKT3',\n",
       " 'BRAF',\n",
       " 'NOTCH1',\n",
       " 'BCL2',\n",
       " 'STAT2',\n",
       " 'FGF9',\n",
       " 'CDKN1B',\n",
       " 'WNT10B',\n",
       " 'NOTCH4',\n",
       " 'IL3',\n",
       " 'IL6R',\n",
       " 'IGF1R',\n",
       " 'KIT',\n",
       " 'SMAD4',\n",
       " 'BBC3',\n",
       " 'NRAS',\n",
       " 'MTOR',\n",
       " 'GLI2',\n",
       " 'SMAD2',\n",
       " 'DVL3',\n",
       " 'RASSF5',\n",
       " 'SLC2A1',\n",
       " 'WNT2B',\n",
       " 'GSTP1',\n",
       " 'FZD9',\n",
       " 'IL3RA',\n",
       " 'FGF23',\n",
       " 'FZD8',\n",
       " 'GSTM5',\n",
       " 'STAT5A',\n",
       " 'WNT9A',\n",
       " 'HRAS',\n",
       " 'STK4',\n",
       " 'FLT3',\n",
       " 'APAF1',\n",
       " 'JAG2',\n",
       " 'WNT7A',\n",
       " 'GAB1',\n",
       " 'FRAT2',\n",
       " 'EGFR',\n",
       " 'WNT10A',\n",
       " 'CDK4',\n",
       " 'LRP5',\n",
       " 'MAP2K2',\n",
       " 'E2F1',\n",
       " 'MGST2',\n",
       " 'ARNT',\n",
       " 'EPOR',\n",
       " 'CALM1',\n",
       " 'GSTA3',\n",
       " 'GSTT2',\n",
       " 'ZBTB17',\n",
       " 'FZD10',\n",
       " 'FGFR4',\n",
       " 'FGFR1',\n",
       " 'CCND2',\n",
       " 'FZD6',\n",
       " 'CCNA2',\n",
       " 'PIK3CD',\n",
       " 'SOS2',\n",
       " 'TGFA',\n",
       " 'DLL1',\n",
       " 'GSTA5',\n",
       " 'HMOX1',\n",
       " 'RALB',\n",
       " 'PRKCB',\n",
       " 'FGF5',\n",
       " 'HIF1A',\n",
       " 'CAMK1',\n",
       " 'IL12A',\n",
       " 'RB1',\n",
       " 'ELK1',\n",
       " 'IFNGR1',\n",
       " 'FGF22',\n",
       " 'BAD',\n",
       " 'PIM1',\n",
       " 'GLI1',\n",
       " 'SKP1',\n",
       " 'GSK3B',\n",
       " 'FGF21',\n",
       " 'FGF1',\n",
       " 'STAT5B',\n",
       " 'HGF',\n",
       " 'TGFB2',\n",
       " 'CUL1',\n",
       " 'LRP6',\n",
       " 'CAMK1G',\n",
       " 'CCNE1',\n",
       " 'IL2RG',\n",
       " 'PLCG2',\n",
       " 'GRB2',\n",
       " 'PTCH2',\n",
       " 'IGF1',\n",
       " 'DLL4',\n",
       " 'ARAF',\n",
       " 'GSTO2',\n",
       " 'TGFBR2',\n",
       " 'CYCS',\n",
       " 'FRAT1',\n",
       " 'FGF2',\n",
       " 'GSTT1',\n",
       " 'WNT1',\n",
       " 'WNT9B',\n",
       " 'AXIN1',\n",
       " 'FGFR2',\n",
       " 'SMAD3',\n",
       " 'GSTM4',\n",
       " 'KLK3',\n",
       " 'TCF7L1',\n",
       " 'FGF10',\n",
       " 'WNT4',\n",
       " 'KRAS',\n",
       " 'IFNA1',\n",
       " 'CSF2RB',\n",
       " 'FGF7']"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "s"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "id": "d4f76a42",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: total: 1.28 s\n",
      "Wall time: 1.3 s\n"
     ]
    }
   ],
   "source": [
    "%%time\n",
    "#导入ensembol-hugo字典\n",
    "hugo_to_ens = pd.read_csv('D:/MyData/deepSurvival/data/PanCancer/hugo_to_ens.tsv', \n",
    "                       sep='\\t', engine='python', index_col=None)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "id": "f539d810",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>geneId</th>\n",
       "      <th>geneName</th>\n",
       "      <th>geneType</th>\n",
       "      <th>geneStatus</th>\n",
       "      <th>transcriptId</th>\n",
       "      <th>transcriptName</th>\n",
       "      <th>transcriptType</th>\n",
       "      <th>transcriptStatus</th>\n",
       "      <th>havanaGeneId</th>\n",
       "      <th>havanaTranscriptId</th>\n",
       "      <th>ccdsId</th>\n",
       "      <th>level</th>\n",
       "      <th>transcriptClass</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>ENSG00000223972.5</td>\n",
       "      <td>DDX11L1</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000456328.2</td>\n",
       "      <td>DDX11L1-002</td>\n",
       "      <td>processed_transcript</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000961.2</td>\n",
       "      <td>OTTHUMT00000362751.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>ENSG00000223972.5</td>\n",
       "      <td>DDX11L1</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000450305.2</td>\n",
       "      <td>DDX11L1-001</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000961.2</td>\n",
       "      <td>OTTHUMT00000002844.2</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ENSG00000227232.5</td>\n",
       "      <td>WASH7P</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000488147.1</td>\n",
       "      <td>WASH7P-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000958.1</td>\n",
       "      <td>OTTHUMT00000002839.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ENSG00000278267.1</td>\n",
       "      <td>MIR6859-1</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000619216.1</td>\n",
       "      <td>MIR6859-1-201</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>nonCoding</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ENSG00000243485.3</td>\n",
       "      <td>RP11-34P13.3</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000473358.1</td>\n",
       "      <td>RP11-34P13.3-001</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000959.2</td>\n",
       "      <td>OTTHUMT00000002840.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>nonCoding</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "              geneId      geneName                            geneType  \\\n",
       "0  ENSG00000223972.5       DDX11L1  transcribed_unprocessed_pseudogene   \n",
       "1  ENSG00000223972.5       DDX11L1  transcribed_unprocessed_pseudogene   \n",
       "2  ENSG00000227232.5        WASH7P              unprocessed_pseudogene   \n",
       "3  ENSG00000278267.1     MIR6859-1                               miRNA   \n",
       "4  ENSG00000243485.3  RP11-34P13.3                             lincRNA   \n",
       "\n",
       "  geneStatus       transcriptId    transcriptName  \\\n",
       "0      KNOWN  ENST00000456328.2       DDX11L1-002   \n",
       "1      KNOWN  ENST00000450305.2       DDX11L1-001   \n",
       "2      KNOWN  ENST00000488147.1        WASH7P-001   \n",
       "3      KNOWN  ENST00000619216.1     MIR6859-1-201   \n",
       "4      KNOWN  ENST00000473358.1  RP11-34P13.3-001   \n",
       "\n",
       "                       transcriptType transcriptStatus          havanaGeneId  \\\n",
       "0                processed_transcript            KNOWN  OTTHUMG00000000961.2   \n",
       "1  transcribed_unprocessed_pseudogene            KNOWN  OTTHUMG00000000961.2   \n",
       "2              unprocessed_pseudogene            KNOWN  OTTHUMG00000000958.1   \n",
       "3                               miRNA            KNOWN                   NaN   \n",
       "4                             lincRNA            KNOWN  OTTHUMG00000000959.2   \n",
       "\n",
       "     havanaTranscriptId ccdsId  level transcriptClass  \n",
       "0  OTTHUMT00000362751.1    NaN      2          pseudo  \n",
       "1  OTTHUMT00000002844.2    NaN      2          pseudo  \n",
       "2  OTTHUMT00000002839.1    NaN      2          pseudo  \n",
       "3                   NaN    NaN      3       nonCoding  \n",
       "4  OTTHUMT00000002840.1    NaN      2       nonCoding  "
      ]
     },
     "execution_count": 16,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hugo_to_ens.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "id": "d1d2c701",
   "metadata": {},
   "outputs": [],
   "source": [
    "geneId=hugo_to_ens['geneId']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "id": "02dae6ae",
   "metadata": {},
   "outputs": [],
   "source": [
    "ensembl=[]\n",
    "for ids in geneId:\n",
    "    ensembl.append(ids[0:15])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "id": "b42e0d1d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['ENSG00000223972',\n",
       " 'ENSG00000223972',\n",
       " 'ENSG00000227232',\n",
       " 'ENSG00000278267',\n",
       " 'ENSG00000243485',\n",
       " 'ENSG00000243485',\n",
       " 'ENSG00000274890',\n",
       " 'ENSG00000237613',\n",
       " 'ENSG00000237613',\n",
       " 'ENSG00000268020',\n",
       " 'ENSG00000240361',\n",
       " 'ENSG00000186092',\n",
       " 'ENSG00000238009',\n",
       " 'ENSG00000239945',\n",
       " 'ENSG00000238009',\n",
       " 'ENSG00000238009',\n",
       " 'ENSG00000238009',\n",
       " 'ENSG00000238009',\n",
       " 'ENSG00000233750',\n",
       " 'ENSG00000268903',\n",
       " 'ENSG00000269981',\n",
       " 'ENSG00000239906',\n",
       " 'ENSG00000241860',\n",
       " 'ENSG00000241860',\n",
       " 'ENSG00000241860',\n",
       " 'ENSG00000222623',\n",
       " 'ENSG00000241599',\n",
       " 'ENSG00000241860',\n",
       " 'ENSG00000279928',\n",
       " 'ENSG00000279457',\n",
       " 'ENSG00000279457',\n",
       " 'ENSG00000279457',\n",
       " 'ENSG00000273874',\n",
       " 'ENSG00000275135',\n",
       " 'ENSG00000228463',\n",
       " 'ENSG00000228463',\n",
       " 'ENSG00000241670',\n",
       " 'ENSG00000228463',\n",
       " 'ENSG00000228463',\n",
       " 'ENSG00000236679',\n",
       " 'ENSG00000236743',\n",
       " 'ENSG00000236601',\n",
       " 'ENSG00000236601',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000269732',\n",
       " 'ENSG00000278566',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000224813',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000233653',\n",
       " 'ENSG00000250575',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000237094',\n",
       " 'ENSG00000278757',\n",
       " 'ENSG00000231709',\n",
       " 'ENSG00000235146',\n",
       " 'ENSG00000235146',\n",
       " 'ENSG00000239664',\n",
       " 'ENSG00000239664',\n",
       " 'ENSG00000230021',\n",
       " 'ENSG00000223659',\n",
       " 'ENSG00000225972',\n",
       " 'ENSG00000225630',\n",
       " 'ENSG00000276171',\n",
       " 'ENSG00000237973',\n",
       " 'ENSG00000278791',\n",
       " 'ENSG00000229344',\n",
       " 'ENSG00000240409',\n",
       " 'ENSG00000248527',\n",
       " 'ENSG00000198744',\n",
       " 'ENSG00000268663',\n",
       " 'ENSG00000273547',\n",
       " 'ENSG00000230021',\n",
       " 'ENSG00000230021',\n",
       " 'ENSG00000230021',\n",
       " 'ENSG00000230021',\n",
       " 'ENSG00000230021',\n",
       " 'ENSG00000229376',\n",
       " 'ENSG00000224956',\n",
       " 'ENSG00000235373',\n",
       " 'ENSG00000223181',\n",
       " 'ENSG00000240618',\n",
       " 'ENSG00000229905',\n",
       " 'ENSG00000228327',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000230092',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000237491',\n",
       " 'ENSG00000230092',\n",
       " 'ENSG00000177757',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000225880',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000228794',\n",
       " 'ENSG00000230368',\n",
       " 'ENSG00000230368',\n",
       " 'ENSG00000230368',\n",
       " 'ENSG00000234711',\n",
       " 'ENSG00000272438',\n",
       " 'ENSG00000230699',\n",
       " 'ENSG00000241180',\n",
       " 'ENSG00000223764',\n",
       " 'ENSG00000223764',\n",
       " 'ENSG00000223764',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000187634',\n",
       " 'ENSG00000188976',\n",
       " 'ENSG00000188976',\n",
       " 'ENSG00000188976',\n",
       " 'ENSG00000188976',\n",
       " 'ENSG00000188976',\n",
       " 'ENSG00000188976',\n",
       " 'ENSG00000187961',\n",
       " 'ENSG00000187961',\n",
       " 'ENSG00000187961',\n",
       " 'ENSG00000187961',\n",
       " 'ENSG00000187961',\n",
       " 'ENSG00000277294',\n",
       " 'ENSG00000187583',\n",
       " 'ENSG00000187583',\n",
       " 'ENSG00000187583',\n",
       " 'ENSG00000187583',\n",
       " 'ENSG00000187583',\n",
       " 'ENSG00000187642',\n",
       " 'ENSG00000187642',\n",
       " 'ENSG00000187642',\n",
       " 'ENSG00000272512',\n",
       " 'ENSG00000188290',\n",
       " 'ENSG00000188290',\n",
       " 'ENSG00000188290',\n",
       " 'ENSG00000188290',\n",
       " 'ENSG00000187608',\n",
       " 'ENSG00000187608',\n",
       " 'ENSG00000231702',\n",
       " 'ENSG00000224969',\n",
       " 'ENSG00000187608',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000188157',\n",
       " 'ENSG00000242590',\n",
       " 'ENSG00000217801',\n",
       " 'ENSG00000217801',\n",
       " 'ENSG00000273443',\n",
       " 'ENSG00000217801',\n",
       " 'ENSG00000217801',\n",
       " 'ENSG00000217801',\n",
       " 'ENSG00000217801',\n",
       " 'ENSG00000237330',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000131591',\n",
       " 'ENSG00000223823',\n",
       " 'ENSG00000207730',\n",
       " 'ENSG00000207607',\n",
       " 'ENSG00000198976',\n",
       " 'ENSG00000272141',\n",
       " 'ENSG00000205231',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000162571',\n",
       " 'ENSG00000186891',\n",
       " 'ENSG00000186891',\n",
       " 'ENSG00000186891',\n",
       " 'ENSG00000186891',\n",
       " 'ENSG00000186827',\n",
       " 'ENSG00000186827',\n",
       " 'ENSG00000186827',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000078808',\n",
       " 'ENSG00000176022',\n",
       " 'ENSG00000184163',\n",
       " 'ENSG00000184163',\n",
       " 'ENSG00000184163',\n",
       " 'ENSG00000184163',\n",
       " 'ENSG00000184163',\n",
       " 'ENSG00000260179',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000160087',\n",
       " 'ENSG00000230415',\n",
       " 'ENSG00000230415',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000162572',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000278073',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000131584',\n",
       " 'ENSG00000169972',\n",
       " 'ENSG00000169972',\n",
       " 'ENSG00000169972',\n",
       " 'ENSG00000169972',\n",
       " 'ENSG00000169972',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000274153',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000240731',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000127054',\n",
       " 'ENSG00000224051',\n",
       " 'ENSG00000224051',\n",
       " 'ENSG00000224051',\n",
       " 'ENSG00000169962',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000275884',\n",
       " 'ENSG00000107404',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000162576',\n",
       " 'ENSG00000175756',\n",
       " 'ENSG00000175756',\n",
       " 'ENSG00000175756',\n",
       " 'ENSG00000175756',\n",
       " 'ENSG00000175756',\n",
       " 'ENSG00000175756',\n",
       " 'ENSG00000223663',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000221978',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000224870',\n",
       " 'ENSG00000242485',\n",
       " 'ENSG00000242485',\n",
       " 'ENSG00000242485',\n",
       " 'ENSG00000242485',\n",
       " 'ENSG00000242485',\n",
       " 'ENSG00000264293',\n",
       " 'ENSG00000242485',\n",
       " 'ENSG00000272455',\n",
       " 'ENSG00000235098',\n",
       " 'ENSG00000235098',\n",
       " 'ENSG00000235098',\n",
       " 'ENSG00000235098',\n",
       " 'ENSG00000235098',\n",
       " 'ENSG00000225905',\n",
       " 'ENSG00000205116',\n",
       " 'ENSG00000225285',\n",
       " 'ENSG00000225285',\n",
       " 'ENSG00000225285',\n",
       " 'ENSG00000225285',\n",
       " 'ENSG00000179403',\n",
       " 'ENSG00000179403',\n",
       " 'ENSG00000179403',\n",
       " 'ENSG00000179403',\n",
       " 'ENSG00000215915',\n",
       " 'ENSG00000215915',\n",
       " 'ENSG00000215915',\n",
       " 'ENSG00000160072',\n",
       " 'ENSG00000160072',\n",
       " 'ENSG00000160072',\n",
       " 'ENSG00000160072',\n",
       " 'ENSG00000160072',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000197785',\n",
       " 'ENSG00000205090',\n",
       " 'ENSG00000205090',\n",
       " 'ENSG00000205090',\n",
       " 'ENSG00000160075',\n",
       " 'ENSG00000160075',\n",
       " 'ENSG00000160075',\n",
       " 'ENSG00000160075',\n",
       " 'ENSG00000215014',\n",
       " 'ENSG00000279244',\n",
       " 'ENSG00000274481',\n",
       " 'ENSG00000280747',\n",
       " 'ENSG00000228594',\n",
       " 'ENSG00000272106',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000197530',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000189409',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000248333',\n",
       " 'ENSG00000272004',\n",
       " 'ENSG00000189339',\n",
       " 'ENSG00000189339',\n",
       " 'ENSG00000189339',\n",
       " 'ENSG00000189339',\n",
       " 'ENSG00000189339',\n",
       " 'ENSG00000269737',\n",
       " 'ENSG00000269227',\n",
       " 'ENSG00000215914',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000268575',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000008128',\n",
       " 'ENSG00000227775',\n",
       " 'ENSG00000227775',\n",
       " 'ENSG00000215790',\n",
       " 'ENSG00000215790',\n",
       " 'ENSG00000215790',\n",
       " 'ENSG00000227775',\n",
       " 'ENSG00000227775',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000008130',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000078369',\n",
       " 'ENSG00000231050',\n",
       " 'ENSG00000169885',\n",
       " 'ENSG00000169885',\n",
       " 'ENSG00000169885',\n",
       " 'ENSG00000169885',\n",
       " 'ENSG00000178821',\n",
       " 'ENSG00000178821',\n",
       " 'ENSG00000178821',\n",
       " 'ENSG00000178821',\n",
       " 'ENSG00000178821',\n",
       " 'ENSG00000178821',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000142609',\n",
       " 'ENSG00000233542',\n",
       " 'ENSG00000187730',\n",
       " 'ENSG00000226969',\n",
       " 'ENSG00000226969',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000271806',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000067606',\n",
       " 'ENSG00000182873',\n",
       " 'ENSG00000182873',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000162585',\n",
       " 'ENSG00000234396',\n",
       " 'ENSG00000277082',\n",
       " 'ENSG00000157933',\n",
       " 'ENSG00000157933',\n",
       " 'ENSG00000157933',\n",
       " 'ENSG00000157933',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000272161',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000269896',\n",
       " 'ENSG00000269896',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000272420',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000116151',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157916',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000157911',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000224387',\n",
       " 'ENSG00000229393',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000149527',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000157881',\n",
       " 'ENSG00000197921',\n",
       " 'ENSG00000272449',\n",
       " 'ENSG00000238164',\n",
       " 'ENSG00000238164',\n",
       " 'ENSG00000238164',\n",
       " 'ENSG00000238164',\n",
       " 'ENSG00000238164',\n",
       " 'ENSG00000238164',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000157873',\n",
       " 'ENSG00000225931',\n",
       " 'ENSG00000228037',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000157870',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000142606',\n",
       " 'ENSG00000237058',\n",
       " 'ENSG00000215912',\n",
       " 'ENSG00000215912',\n",
       " 'ENSG00000215912',\n",
       " 'ENSG00000233234',\n",
       " 'ENSG00000231630',\n",
       " 'ENSG00000169717',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000177133',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000226286',\n",
       " 'ENSG00000279839',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000272235',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000142611',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000130762',\n",
       " 'ENSG00000272088',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000162591',\n",
       " 'ENSG00000207776',\n",
       " 'ENSG00000238260',\n",
       " 'ENSG00000158109',\n",
       " 'ENSG00000158109',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000116213',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000227589',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000235131',\n",
       " 'ENSG00000078900',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000276189',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000227372',\n",
       " 'ENSG00000162592',\n",
       " 'ENSG00000162592',\n",
       " 'ENSG00000235169',\n",
       " 'ENSG00000235169',\n",
       " 'ENSG00000235169',\n",
       " 'ENSG00000130764',\n",
       " 'ENSG00000130764',\n",
       " 'ENSG00000130764',\n",
       " 'ENSG00000266075',\n",
       " 'ENSG00000272153',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000116198',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000169598',\n",
       " 'ENSG00000198912',\n",
       " 'ENSG00000198912',\n",
       " 'ENSG00000198912',\n",
       " 'ENSG00000236423',\n",
       " 'ENSG00000236423',\n",
       " 'ENSG00000236423',\n",
       " 'ENSG00000233304',\n",
       " 'ENSG00000233304',\n",
       " 'ENSG00000226374',\n",
       " 'ENSG00000229280',\n",
       " 'ENSG00000235054',\n",
       " 'ENSG00000235054',\n",
       " 'ENSG00000227169',\n",
       " 'ENSG00000232596',\n",
       " 'ENSG00000196581',\n",
       " 'ENSG00000196581',\n",
       " 'ENSG00000196581',\n",
       " 'ENSG00000277731',\n",
       " 'ENSG00000231510',\n",
       " 'ENSG00000260972',\n",
       " 'ENSG00000264341',\n",
       " 'ENSG00000236948',\n",
       " 'ENSG00000216045',\n",
       " 'ENSG00000264101',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000131697',\n",
       " 'ENSG00000266687',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000069424',\n",
       " 'ENSG00000116254',\n",
       " 'ENSG00000116254',\n",
       " 'ENSG00000116254',\n",
       " 'ENSG00000116254',\n",
       " 'ENSG00000116254',\n",
       " 'ENSG00000116254',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000116251',\n",
       " 'ENSG00000226944',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000158286',\n",
       " 'ENSG00000116237',\n",
       " 'ENSG00000116237',\n",
       " 'ENSG00000116237',\n",
       " 'ENSG00000116237',\n",
       " 'ENSG00000225077',\n",
       " 'ENSG00000225077',\n",
       " 'ENSG00000173673',\n",
       " 'ENSG00000158292',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000097021',\n",
       " 'ENSG00000271746',\n",
       " 'ENSG00000069812',\n",
       " 'ENSG00000069812',\n",
       " 'ENSG00000069812',\n",
       " 'ENSG00000069812',\n",
       " 'ENSG00000069812',\n",
       " 'ENSG00000069812',\n",
       " 'ENSG00000187017',\n",
       " 'ENSG00000265392',\n",
       " 'ENSG00000187017',\n",
       " 'ENSG00000187017',\n",
       " ...]"
      ]
     },
     "execution_count": 19,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ensembl"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "id": "5bc74400",
   "metadata": {},
   "outputs": [],
   "source": [
    "hugo_to_ens['ensembl']=ensembl"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "id": "81f951ca",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>geneId</th>\n",
       "      <th>geneName</th>\n",
       "      <th>geneType</th>\n",
       "      <th>geneStatus</th>\n",
       "      <th>transcriptId</th>\n",
       "      <th>transcriptName</th>\n",
       "      <th>transcriptType</th>\n",
       "      <th>transcriptStatus</th>\n",
       "      <th>havanaGeneId</th>\n",
       "      <th>havanaTranscriptId</th>\n",
       "      <th>ccdsId</th>\n",
       "      <th>level</th>\n",
       "      <th>transcriptClass</th>\n",
       "      <th>ensembl</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>ENSG00000223972.5</td>\n",
       "      <td>DDX11L1</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000456328.2</td>\n",
       "      <td>DDX11L1-002</td>\n",
       "      <td>processed_transcript</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000961.2</td>\n",
       "      <td>OTTHUMT00000362751.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000223972</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>ENSG00000223972.5</td>\n",
       "      <td>DDX11L1</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000450305.2</td>\n",
       "      <td>DDX11L1-001</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000961.2</td>\n",
       "      <td>OTTHUMT00000002844.2</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000223972</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ENSG00000227232.5</td>\n",
       "      <td>WASH7P</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000488147.1</td>\n",
       "      <td>WASH7P-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000958.1</td>\n",
       "      <td>OTTHUMT00000002839.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000227232</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ENSG00000278267.1</td>\n",
       "      <td>MIR6859-1</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000619216.1</td>\n",
       "      <td>MIR6859-1-201</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000278267</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ENSG00000243485.3</td>\n",
       "      <td>RP11-34P13.3</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000473358.1</td>\n",
       "      <td>RP11-34P13.3-001</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000959.2</td>\n",
       "      <td>OTTHUMT00000002840.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000243485</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "              geneId      geneName                            geneType  \\\n",
       "0  ENSG00000223972.5       DDX11L1  transcribed_unprocessed_pseudogene   \n",
       "1  ENSG00000223972.5       DDX11L1  transcribed_unprocessed_pseudogene   \n",
       "2  ENSG00000227232.5        WASH7P              unprocessed_pseudogene   \n",
       "3  ENSG00000278267.1     MIR6859-1                               miRNA   \n",
       "4  ENSG00000243485.3  RP11-34P13.3                             lincRNA   \n",
       "\n",
       "  geneStatus       transcriptId    transcriptName  \\\n",
       "0      KNOWN  ENST00000456328.2       DDX11L1-002   \n",
       "1      KNOWN  ENST00000450305.2       DDX11L1-001   \n",
       "2      KNOWN  ENST00000488147.1        WASH7P-001   \n",
       "3      KNOWN  ENST00000619216.1     MIR6859-1-201   \n",
       "4      KNOWN  ENST00000473358.1  RP11-34P13.3-001   \n",
       "\n",
       "                       transcriptType transcriptStatus          havanaGeneId  \\\n",
       "0                processed_transcript            KNOWN  OTTHUMG00000000961.2   \n",
       "1  transcribed_unprocessed_pseudogene            KNOWN  OTTHUMG00000000961.2   \n",
       "2              unprocessed_pseudogene            KNOWN  OTTHUMG00000000958.1   \n",
       "3                               miRNA            KNOWN                   NaN   \n",
       "4                             lincRNA            KNOWN  OTTHUMG00000000959.2   \n",
       "\n",
       "     havanaTranscriptId ccdsId  level transcriptClass          ensembl  \n",
       "0  OTTHUMT00000362751.1    NaN      2          pseudo  ENSG00000223972  \n",
       "1  OTTHUMT00000002844.2    NaN      2          pseudo  ENSG00000223972  \n",
       "2  OTTHUMT00000002839.1    NaN      2          pseudo  ENSG00000227232  \n",
       "3                   NaN    NaN      3       nonCoding  ENSG00000278267  \n",
       "4  OTTHUMT00000002840.1    NaN      2       nonCoding  ENSG00000243485  "
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hugo_to_ens.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "id": "5d51c19c",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>geneId</th>\n",
       "      <th>geneName</th>\n",
       "      <th>geneType</th>\n",
       "      <th>geneStatus</th>\n",
       "      <th>transcriptId</th>\n",
       "      <th>transcriptName</th>\n",
       "      <th>transcriptType</th>\n",
       "      <th>transcriptStatus</th>\n",
       "      <th>havanaGeneId</th>\n",
       "      <th>havanaTranscriptId</th>\n",
       "      <th>ccdsId</th>\n",
       "      <th>level</th>\n",
       "      <th>transcriptClass</th>\n",
       "      <th>ensembl</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>ENSG00000223972.5</td>\n",
       "      <td>DDX11L1</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000456328.2</td>\n",
       "      <td>DDX11L1-002</td>\n",
       "      <td>processed_transcript</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000961.2</td>\n",
       "      <td>OTTHUMT00000362751.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000223972</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ENSG00000227232.5</td>\n",
       "      <td>WASH7P</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000488147.1</td>\n",
       "      <td>WASH7P-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000958.1</td>\n",
       "      <td>OTTHUMT00000002839.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000227232</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ENSG00000278267.1</td>\n",
       "      <td>MIR6859-1</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000619216.1</td>\n",
       "      <td>MIR6859-1-201</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000278267</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ENSG00000243485.3</td>\n",
       "      <td>RP11-34P13.3</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000473358.1</td>\n",
       "      <td>RP11-34P13.3-001</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000959.2</td>\n",
       "      <td>OTTHUMT00000002840.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000243485</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>ENSG00000274890.1</td>\n",
       "      <td>MIR1302-2</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000607096.1</td>\n",
       "      <td>MIR1302-2-201</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000274890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215272</th>\n",
       "      <td>ENSG00000224240.1</td>\n",
       "      <td>CYCSP49</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000420810.1</td>\n",
       "      <td>CYCSP49-001</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036760.1</td>\n",
       "      <td>OTTHUMT00000089321.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000224240</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215273</th>\n",
       "      <td>ENSG00000227629.1</td>\n",
       "      <td>SLC25A15P1</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000456738.1</td>\n",
       "      <td>SLC25A15P1-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036811.1</td>\n",
       "      <td>OTTHUMT00000089407.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000227629</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215274</th>\n",
       "      <td>ENSG00000237917.1</td>\n",
       "      <td>PARP4P1</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000435945.1</td>\n",
       "      <td>PARP4P1-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036812.1</td>\n",
       "      <td>OTTHUMT00000089408.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000237917</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215275</th>\n",
       "      <td>ENSG00000231514.1</td>\n",
       "      <td>FAM58CP</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000435741.1</td>\n",
       "      <td>FAM58CP-001</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036813.1</td>\n",
       "      <td>OTTHUMT00000089409.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000231514</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215276</th>\n",
       "      <td>ENSG00000235857.1</td>\n",
       "      <td>CTBP2P1</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000431853.1</td>\n",
       "      <td>CTBP2P1-001</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036770.1</td>\n",
       "      <td>OTTHUMT00000089331.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000235857</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>65670 rows × 14 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                   geneId      geneName                            geneType  \\\n",
       "0       ENSG00000223972.5       DDX11L1  transcribed_unprocessed_pseudogene   \n",
       "2       ENSG00000227232.5        WASH7P              unprocessed_pseudogene   \n",
       "3       ENSG00000278267.1     MIR6859-1                               miRNA   \n",
       "4       ENSG00000243485.3  RP11-34P13.3                             lincRNA   \n",
       "6       ENSG00000274890.1     MIR1302-2                               miRNA   \n",
       "...                   ...           ...                                 ...   \n",
       "215272  ENSG00000224240.1       CYCSP49                processed_pseudogene   \n",
       "215273  ENSG00000227629.1    SLC25A15P1              unprocessed_pseudogene   \n",
       "215274  ENSG00000237917.1       PARP4P1              unprocessed_pseudogene   \n",
       "215275  ENSG00000231514.1       FAM58CP                processed_pseudogene   \n",
       "215276  ENSG00000235857.1       CTBP2P1                processed_pseudogene   \n",
       "\n",
       "       geneStatus       transcriptId    transcriptName  \\\n",
       "0           KNOWN  ENST00000456328.2       DDX11L1-002   \n",
       "2           KNOWN  ENST00000488147.1        WASH7P-001   \n",
       "3           KNOWN  ENST00000619216.1     MIR6859-1-201   \n",
       "4           KNOWN  ENST00000473358.1  RP11-34P13.3-001   \n",
       "6           KNOWN  ENST00000607096.1     MIR1302-2-201   \n",
       "...           ...                ...               ...   \n",
       "215272      KNOWN  ENST00000420810.1       CYCSP49-001   \n",
       "215273      KNOWN  ENST00000456738.1    SLC25A15P1-001   \n",
       "215274      KNOWN  ENST00000435945.1       PARP4P1-001   \n",
       "215275      KNOWN  ENST00000435741.1       FAM58CP-001   \n",
       "215276      KNOWN  ENST00000431853.1       CTBP2P1-001   \n",
       "\n",
       "                transcriptType transcriptStatus          havanaGeneId  \\\n",
       "0         processed_transcript            KNOWN  OTTHUMG00000000961.2   \n",
       "2       unprocessed_pseudogene            KNOWN  OTTHUMG00000000958.1   \n",
       "3                        miRNA            KNOWN                   NaN   \n",
       "4                      lincRNA            KNOWN  OTTHUMG00000000959.2   \n",
       "6                        miRNA            KNOWN                   NaN   \n",
       "...                        ...              ...                   ...   \n",
       "215272    processed_pseudogene            KNOWN  OTTHUMG00000036760.1   \n",
       "215273  unprocessed_pseudogene            KNOWN  OTTHUMG00000036811.1   \n",
       "215274  unprocessed_pseudogene            KNOWN  OTTHUMG00000036812.1   \n",
       "215275    processed_pseudogene            KNOWN  OTTHUMG00000036813.1   \n",
       "215276    processed_pseudogene            KNOWN  OTTHUMG00000036770.1   \n",
       "\n",
       "          havanaTranscriptId ccdsId  level transcriptClass          ensembl  \n",
       "0       OTTHUMT00000362751.1    NaN      2          pseudo  ENSG00000223972  \n",
       "2       OTTHUMT00000002839.1    NaN      2          pseudo  ENSG00000227232  \n",
       "3                        NaN    NaN      3       nonCoding  ENSG00000278267  \n",
       "4       OTTHUMT00000002840.1    NaN      2       nonCoding  ENSG00000243485  \n",
       "6                        NaN    NaN      3       nonCoding  ENSG00000274890  \n",
       "...                      ...    ...    ...             ...              ...  \n",
       "215272  OTTHUMT00000089321.1    NaN      1          pseudo  ENSG00000224240  \n",
       "215273  OTTHUMT00000089407.1    NaN      2          pseudo  ENSG00000227629  \n",
       "215274  OTTHUMT00000089408.1    NaN      1          pseudo  ENSG00000237917  \n",
       "215275  OTTHUMT00000089409.1    NaN      1          pseudo  ENSG00000231514  \n",
       "215276  OTTHUMT00000089331.1    NaN      1          pseudo  ENSG00000235857  \n",
       "\n",
       "[65670 rows x 14 columns]"
      ]
     },
     "execution_count": 22,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hugo_to_ens.drop_duplicates(subset='ensembl',keep='first')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "id": "7bee2509",
   "metadata": {},
   "outputs": [],
   "source": [
    "hugo_to_ens=hugo_to_ens.drop_duplicates(subset='ensembl',keep='first')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "id": "86b76f46",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>geneId</th>\n",
       "      <th>geneName</th>\n",
       "      <th>geneType</th>\n",
       "      <th>geneStatus</th>\n",
       "      <th>transcriptId</th>\n",
       "      <th>transcriptName</th>\n",
       "      <th>transcriptType</th>\n",
       "      <th>transcriptStatus</th>\n",
       "      <th>havanaGeneId</th>\n",
       "      <th>havanaTranscriptId</th>\n",
       "      <th>ccdsId</th>\n",
       "      <th>level</th>\n",
       "      <th>transcriptClass</th>\n",
       "      <th>ensembl</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>ENSG00000223972.5</td>\n",
       "      <td>DDX11L1</td>\n",
       "      <td>transcribed_unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000456328.2</td>\n",
       "      <td>DDX11L1-002</td>\n",
       "      <td>processed_transcript</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000961.2</td>\n",
       "      <td>OTTHUMT00000362751.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000223972</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>ENSG00000227232.5</td>\n",
       "      <td>WASH7P</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000488147.1</td>\n",
       "      <td>WASH7P-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000958.1</td>\n",
       "      <td>OTTHUMT00000002839.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000227232</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>ENSG00000278267.1</td>\n",
       "      <td>MIR6859-1</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000619216.1</td>\n",
       "      <td>MIR6859-1-201</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000278267</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ENSG00000243485.3</td>\n",
       "      <td>RP11-34P13.3</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000473358.1</td>\n",
       "      <td>RP11-34P13.3-001</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000000959.2</td>\n",
       "      <td>OTTHUMT00000002840.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000243485</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>ENSG00000274890.1</td>\n",
       "      <td>MIR1302-2</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000607096.1</td>\n",
       "      <td>MIR1302-2-201</td>\n",
       "      <td>miRNA</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000274890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215272</th>\n",
       "      <td>ENSG00000224240.1</td>\n",
       "      <td>CYCSP49</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000420810.1</td>\n",
       "      <td>CYCSP49-001</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036760.1</td>\n",
       "      <td>OTTHUMT00000089321.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000224240</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215273</th>\n",
       "      <td>ENSG00000227629.1</td>\n",
       "      <td>SLC25A15P1</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000456738.1</td>\n",
       "      <td>SLC25A15P1-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036811.1</td>\n",
       "      <td>OTTHUMT00000089407.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000227629</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215274</th>\n",
       "      <td>ENSG00000237917.1</td>\n",
       "      <td>PARP4P1</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000435945.1</td>\n",
       "      <td>PARP4P1-001</td>\n",
       "      <td>unprocessed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036812.1</td>\n",
       "      <td>OTTHUMT00000089408.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000237917</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215275</th>\n",
       "      <td>ENSG00000231514.1</td>\n",
       "      <td>FAM58CP</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000435741.1</td>\n",
       "      <td>FAM58CP-001</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036813.1</td>\n",
       "      <td>OTTHUMT00000089409.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000231514</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>215276</th>\n",
       "      <td>ENSG00000235857.1</td>\n",
       "      <td>CTBP2P1</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000431853.1</td>\n",
       "      <td>CTBP2P1-001</td>\n",
       "      <td>processed_pseudogene</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000036770.1</td>\n",
       "      <td>OTTHUMT00000089331.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1</td>\n",
       "      <td>pseudo</td>\n",
       "      <td>ENSG00000235857</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>65670 rows × 14 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                   geneId      geneName                            geneType  \\\n",
       "0       ENSG00000223972.5       DDX11L1  transcribed_unprocessed_pseudogene   \n",
       "2       ENSG00000227232.5        WASH7P              unprocessed_pseudogene   \n",
       "3       ENSG00000278267.1     MIR6859-1                               miRNA   \n",
       "4       ENSG00000243485.3  RP11-34P13.3                             lincRNA   \n",
       "6       ENSG00000274890.1     MIR1302-2                               miRNA   \n",
       "...                   ...           ...                                 ...   \n",
       "215272  ENSG00000224240.1       CYCSP49                processed_pseudogene   \n",
       "215273  ENSG00000227629.1    SLC25A15P1              unprocessed_pseudogene   \n",
       "215274  ENSG00000237917.1       PARP4P1              unprocessed_pseudogene   \n",
       "215275  ENSG00000231514.1       FAM58CP                processed_pseudogene   \n",
       "215276  ENSG00000235857.1       CTBP2P1                processed_pseudogene   \n",
       "\n",
       "       geneStatus       transcriptId    transcriptName  \\\n",
       "0           KNOWN  ENST00000456328.2       DDX11L1-002   \n",
       "2           KNOWN  ENST00000488147.1        WASH7P-001   \n",
       "3           KNOWN  ENST00000619216.1     MIR6859-1-201   \n",
       "4           KNOWN  ENST00000473358.1  RP11-34P13.3-001   \n",
       "6           KNOWN  ENST00000607096.1     MIR1302-2-201   \n",
       "...           ...                ...               ...   \n",
       "215272      KNOWN  ENST00000420810.1       CYCSP49-001   \n",
       "215273      KNOWN  ENST00000456738.1    SLC25A15P1-001   \n",
       "215274      KNOWN  ENST00000435945.1       PARP4P1-001   \n",
       "215275      KNOWN  ENST00000435741.1       FAM58CP-001   \n",
       "215276      KNOWN  ENST00000431853.1       CTBP2P1-001   \n",
       "\n",
       "                transcriptType transcriptStatus          havanaGeneId  \\\n",
       "0         processed_transcript            KNOWN  OTTHUMG00000000961.2   \n",
       "2       unprocessed_pseudogene            KNOWN  OTTHUMG00000000958.1   \n",
       "3                        miRNA            KNOWN                   NaN   \n",
       "4                      lincRNA            KNOWN  OTTHUMG00000000959.2   \n",
       "6                        miRNA            KNOWN                   NaN   \n",
       "...                        ...              ...                   ...   \n",
       "215272    processed_pseudogene            KNOWN  OTTHUMG00000036760.1   \n",
       "215273  unprocessed_pseudogene            KNOWN  OTTHUMG00000036811.1   \n",
       "215274  unprocessed_pseudogene            KNOWN  OTTHUMG00000036812.1   \n",
       "215275    processed_pseudogene            KNOWN  OTTHUMG00000036813.1   \n",
       "215276    processed_pseudogene            KNOWN  OTTHUMG00000036770.1   \n",
       "\n",
       "          havanaTranscriptId ccdsId  level transcriptClass          ensembl  \n",
       "0       OTTHUMT00000362751.1    NaN      2          pseudo  ENSG00000223972  \n",
       "2       OTTHUMT00000002839.1    NaN      2          pseudo  ENSG00000227232  \n",
       "3                        NaN    NaN      3       nonCoding  ENSG00000278267  \n",
       "4       OTTHUMT00000002840.1    NaN      2       nonCoding  ENSG00000243485  \n",
       "6                        NaN    NaN      3       nonCoding  ENSG00000274890  \n",
       "...                      ...    ...    ...             ...              ...  \n",
       "215272  OTTHUMT00000089321.1    NaN      1          pseudo  ENSG00000224240  \n",
       "215273  OTTHUMT00000089407.1    NaN      2          pseudo  ENSG00000227629  \n",
       "215274  OTTHUMT00000089408.1    NaN      1          pseudo  ENSG00000237917  \n",
       "215275  OTTHUMT00000089409.1    NaN      1          pseudo  ENSG00000231514  \n",
       "215276  OTTHUMT00000089331.1    NaN      1          pseudo  ENSG00000235857  \n",
       "\n",
       "[65670 rows x 14 columns]"
      ]
     },
     "execution_count": 24,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hugo_to_ens"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "id": "24140929",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>geneId</th>\n",
       "      <th>geneName</th>\n",
       "      <th>geneType</th>\n",
       "      <th>geneStatus</th>\n",
       "      <th>transcriptId</th>\n",
       "      <th>transcriptName</th>\n",
       "      <th>transcriptType</th>\n",
       "      <th>transcriptStatus</th>\n",
       "      <th>havanaGeneId</th>\n",
       "      <th>havanaTranscriptId</th>\n",
       "      <th>ccdsId</th>\n",
       "      <th>level</th>\n",
       "      <th>transcriptClass</th>\n",
       "      <th>ensembl</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>371</th>\n",
       "      <td>ENSG00000107404.17</td>\n",
       "      <td>DVL1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000378891.9</td>\n",
       "      <td>DVL1-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000003069.4</td>\n",
       "      <td>OTTHUMT00000008487.2</td>\n",
       "      <td>CCDS22.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000107404</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1261</th>\n",
       "      <td>ENSG00000171608.15</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000536656.5</td>\n",
       "      <td>PIK3CD-201</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000001450.2</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000171608</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1439</th>\n",
       "      <td>ENSG00000198793.12</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000376838.5</td>\n",
       "      <td>MTOR-002</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000002001.2</td>\n",
       "      <td>OTTHUMT00000005559.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000198793</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1766</th>\n",
       "      <td>ENSG00000132906.17</td>\n",
       "      <td>CASP9</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000546424.5</td>\n",
       "      <td>CASP9-009</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000002256.5</td>\n",
       "      <td>OTTHUMT00000407260.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000132906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1842</th>\n",
       "      <td>ENSG00000116809.11</td>\n",
       "      <td>ZBTB17</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000462525.1</td>\n",
       "      <td>ZBTB17-014</td>\n",
       "      <td>processed_transcript</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000009377.2</td>\n",
       "      <td>OTTHUMT00000026011.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000116809</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>209916</th>\n",
       "      <td>ENSG00000126767.17</td>\n",
       "      <td>ELK1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000247161.7</td>\n",
       "      <td>ELK1-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000021452.3</td>\n",
       "      <td>OTTHUMT00000056436.1</td>\n",
       "      <td>CCDS14283.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000126767</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>210910</th>\n",
       "      <td>ENSG00000169083.15</td>\n",
       "      <td>AR</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000396044.7</td>\n",
       "      <td>AR-201</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000021740.2</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000169083</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>211060</th>\n",
       "      <td>ENSG00000147168.12</td>\n",
       "      <td>IL2RG</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000276110.6</td>\n",
       "      <td>IL2RG-006</td>\n",
       "      <td>retained_intron</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000021787.2</td>\n",
       "      <td>OTTHUMT00000359097.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>problem</td>\n",
       "      <td>ENSG00000147168</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>211423</th>\n",
       "      <td>ENSG00000196468.7</td>\n",
       "      <td>FGF16</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000439435.2</td>\n",
       "      <td>FGF16-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000013133.2</td>\n",
       "      <td>OTTHUMT00000036814.2</td>\n",
       "      <td>CCDS75996.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000196468</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>212535</th>\n",
       "      <td>ENSG00000131724.10</td>\n",
       "      <td>IL13RA1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000371666.7</td>\n",
       "      <td>IL13RA1-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000022258.1</td>\n",
       "      <td>OTTHUMT00000058009.1</td>\n",
       "      <td>CCDS14573.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000131724</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>290 rows × 14 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                    geneId geneName        geneType geneStatus  \\\n",
       "371     ENSG00000107404.17     DVL1  protein_coding      KNOWN   \n",
       "1261    ENSG00000171608.15   PIK3CD  protein_coding      KNOWN   \n",
       "1439    ENSG00000198793.12     MTOR  protein_coding      KNOWN   \n",
       "1766    ENSG00000132906.17    CASP9  protein_coding      KNOWN   \n",
       "1842    ENSG00000116809.11   ZBTB17  protein_coding      KNOWN   \n",
       "...                    ...      ...             ...        ...   \n",
       "209916  ENSG00000126767.17     ELK1  protein_coding      KNOWN   \n",
       "210910  ENSG00000169083.15       AR  protein_coding      KNOWN   \n",
       "211060  ENSG00000147168.12    IL2RG  protein_coding      KNOWN   \n",
       "211423   ENSG00000196468.7    FGF16  protein_coding      KNOWN   \n",
       "212535  ENSG00000131724.10  IL13RA1  protein_coding      KNOWN   \n",
       "\n",
       "             transcriptId transcriptName        transcriptType  \\\n",
       "371     ENST00000378891.9       DVL1-001        protein_coding   \n",
       "1261    ENST00000536656.5     PIK3CD-201        protein_coding   \n",
       "1439    ENST00000376838.5       MTOR-002        protein_coding   \n",
       "1766    ENST00000546424.5      CASP9-009        protein_coding   \n",
       "1842    ENST00000462525.1     ZBTB17-014  processed_transcript   \n",
       "...                   ...            ...                   ...   \n",
       "209916  ENST00000247161.7       ELK1-001        protein_coding   \n",
       "210910  ENST00000396044.7         AR-201        protein_coding   \n",
       "211060  ENST00000276110.6      IL2RG-006       retained_intron   \n",
       "211423  ENST00000439435.2      FGF16-001        protein_coding   \n",
       "212535  ENST00000371666.7    IL13RA1-001        protein_coding   \n",
       "\n",
       "       transcriptStatus          havanaGeneId    havanaTranscriptId  \\\n",
       "371               KNOWN  OTTHUMG00000003069.4  OTTHUMT00000008487.2   \n",
       "1261              KNOWN  OTTHUMG00000001450.2                   NaN   \n",
       "1439              KNOWN  OTTHUMG00000002001.2  OTTHUMT00000005559.1   \n",
       "1766              KNOWN  OTTHUMG00000002256.5  OTTHUMT00000407260.1   \n",
       "1842              KNOWN  OTTHUMG00000009377.2  OTTHUMT00000026011.1   \n",
       "...                 ...                   ...                   ...   \n",
       "209916            KNOWN  OTTHUMG00000021452.3  OTTHUMT00000056436.1   \n",
       "210910            KNOWN  OTTHUMG00000021740.2                   NaN   \n",
       "211060            KNOWN  OTTHUMG00000021787.2  OTTHUMT00000359097.1   \n",
       "211423            KNOWN  OTTHUMG00000013133.2  OTTHUMT00000036814.2   \n",
       "212535            KNOWN  OTTHUMG00000022258.1  OTTHUMT00000058009.1   \n",
       "\n",
       "             ccdsId  level transcriptClass          ensembl  \n",
       "371        CCDS22.1      2          coding  ENSG00000107404  \n",
       "1261            NaN      3          coding  ENSG00000171608  \n",
       "1439            NaN      2          coding  ENSG00000198793  \n",
       "1766            NaN      2          coding  ENSG00000132906  \n",
       "1842            NaN      2       nonCoding  ENSG00000116809  \n",
       "...             ...    ...             ...              ...  \n",
       "209916  CCDS14283.1      2          coding  ENSG00000126767  \n",
       "210910          NaN      3          coding  ENSG00000169083  \n",
       "211060          NaN      2         problem  ENSG00000147168  \n",
       "211423  CCDS75996.1      2          coding  ENSG00000196468  \n",
       "212535  CCDS14573.1      2          coding  ENSG00000131724  \n",
       "\n",
       "[290 rows x 14 columns]"
      ]
     },
     "execution_count": 25,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hugo_to_ens = hugo_to_ens[hugo_to_ens['geneName'].isin(s)]\n",
    "hugo_to_ens"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 26,
   "id": "dff10260",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>geneId</th>\n",
       "      <th>geneName</th>\n",
       "      <th>geneType</th>\n",
       "      <th>geneStatus</th>\n",
       "      <th>transcriptId</th>\n",
       "      <th>transcriptName</th>\n",
       "      <th>transcriptType</th>\n",
       "      <th>transcriptStatus</th>\n",
       "      <th>havanaGeneId</th>\n",
       "      <th>havanaTranscriptId</th>\n",
       "      <th>ccdsId</th>\n",
       "      <th>level</th>\n",
       "      <th>transcriptClass</th>\n",
       "      <th>ensembl</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>371</th>\n",
       "      <td>ENSG00000107404.17</td>\n",
       "      <td>DVL1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000378891.9</td>\n",
       "      <td>DVL1-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000003069.4</td>\n",
       "      <td>OTTHUMT00000008487.2</td>\n",
       "      <td>CCDS22.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000107404</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1261</th>\n",
       "      <td>ENSG00000171608.15</td>\n",
       "      <td>PIK3CD</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000536656.5</td>\n",
       "      <td>PIK3CD-201</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000001450.2</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000171608</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1439</th>\n",
       "      <td>ENSG00000198793.12</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000376838.5</td>\n",
       "      <td>MTOR-002</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000002001.2</td>\n",
       "      <td>OTTHUMT00000005559.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000198793</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1766</th>\n",
       "      <td>ENSG00000132906.17</td>\n",
       "      <td>CASP9</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000546424.5</td>\n",
       "      <td>CASP9-009</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000002256.5</td>\n",
       "      <td>OTTHUMT00000407260.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000132906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1842</th>\n",
       "      <td>ENSG00000116809.11</td>\n",
       "      <td>ZBTB17</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000462525.1</td>\n",
       "      <td>ZBTB17-014</td>\n",
       "      <td>processed_transcript</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000009377.2</td>\n",
       "      <td>OTTHUMT00000026011.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>nonCoding</td>\n",
       "      <td>ENSG00000116809</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>209916</th>\n",
       "      <td>ENSG00000126767.17</td>\n",
       "      <td>ELK1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000247161.7</td>\n",
       "      <td>ELK1-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000021452.3</td>\n",
       "      <td>OTTHUMT00000056436.1</td>\n",
       "      <td>CCDS14283.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000126767</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>210910</th>\n",
       "      <td>ENSG00000169083.15</td>\n",
       "      <td>AR</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000396044.7</td>\n",
       "      <td>AR-201</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000021740.2</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000169083</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>211060</th>\n",
       "      <td>ENSG00000147168.12</td>\n",
       "      <td>IL2RG</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000276110.6</td>\n",
       "      <td>IL2RG-006</td>\n",
       "      <td>retained_intron</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000021787.2</td>\n",
       "      <td>OTTHUMT00000359097.1</td>\n",
       "      <td>NaN</td>\n",
       "      <td>2</td>\n",
       "      <td>problem</td>\n",
       "      <td>ENSG00000147168</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>211423</th>\n",
       "      <td>ENSG00000196468.7</td>\n",
       "      <td>FGF16</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000439435.2</td>\n",
       "      <td>FGF16-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000013133.2</td>\n",
       "      <td>OTTHUMT00000036814.2</td>\n",
       "      <td>CCDS75996.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000196468</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>212535</th>\n",
       "      <td>ENSG00000131724.10</td>\n",
       "      <td>IL13RA1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>ENST00000371666.7</td>\n",
       "      <td>IL13RA1-001</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>KNOWN</td>\n",
       "      <td>OTTHUMG00000022258.1</td>\n",
       "      <td>OTTHUMT00000058009.1</td>\n",
       "      <td>CCDS14573.1</td>\n",
       "      <td>2</td>\n",
       "      <td>coding</td>\n",
       "      <td>ENSG00000131724</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>276 rows × 14 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                    geneId geneName        geneType geneStatus  \\\n",
       "371     ENSG00000107404.17     DVL1  protein_coding      KNOWN   \n",
       "1261    ENSG00000171608.15   PIK3CD  protein_coding      KNOWN   \n",
       "1439    ENSG00000198793.12     MTOR  protein_coding      KNOWN   \n",
       "1766    ENSG00000132906.17    CASP9  protein_coding      KNOWN   \n",
       "1842    ENSG00000116809.11   ZBTB17  protein_coding      KNOWN   \n",
       "...                    ...      ...             ...        ...   \n",
       "209916  ENSG00000126767.17     ELK1  protein_coding      KNOWN   \n",
       "210910  ENSG00000169083.15       AR  protein_coding      KNOWN   \n",
       "211060  ENSG00000147168.12    IL2RG  protein_coding      KNOWN   \n",
       "211423   ENSG00000196468.7    FGF16  protein_coding      KNOWN   \n",
       "212535  ENSG00000131724.10  IL13RA1  protein_coding      KNOWN   \n",
       "\n",
       "             transcriptId transcriptName        transcriptType  \\\n",
       "371     ENST00000378891.9       DVL1-001        protein_coding   \n",
       "1261    ENST00000536656.5     PIK3CD-201        protein_coding   \n",
       "1439    ENST00000376838.5       MTOR-002        protein_coding   \n",
       "1766    ENST00000546424.5      CASP9-009        protein_coding   \n",
       "1842    ENST00000462525.1     ZBTB17-014  processed_transcript   \n",
       "...                   ...            ...                   ...   \n",
       "209916  ENST00000247161.7       ELK1-001        protein_coding   \n",
       "210910  ENST00000396044.7         AR-201        protein_coding   \n",
       "211060  ENST00000276110.6      IL2RG-006       retained_intron   \n",
       "211423  ENST00000439435.2      FGF16-001        protein_coding   \n",
       "212535  ENST00000371666.7    IL13RA1-001        protein_coding   \n",
       "\n",
       "       transcriptStatus          havanaGeneId    havanaTranscriptId  \\\n",
       "371               KNOWN  OTTHUMG00000003069.4  OTTHUMT00000008487.2   \n",
       "1261              KNOWN  OTTHUMG00000001450.2                   NaN   \n",
       "1439              KNOWN  OTTHUMG00000002001.2  OTTHUMT00000005559.1   \n",
       "1766              KNOWN  OTTHUMG00000002256.5  OTTHUMT00000407260.1   \n",
       "1842              KNOWN  OTTHUMG00000009377.2  OTTHUMT00000026011.1   \n",
       "...                 ...                   ...                   ...   \n",
       "209916            KNOWN  OTTHUMG00000021452.3  OTTHUMT00000056436.1   \n",
       "210910            KNOWN  OTTHUMG00000021740.2                   NaN   \n",
       "211060            KNOWN  OTTHUMG00000021787.2  OTTHUMT00000359097.1   \n",
       "211423            KNOWN  OTTHUMG00000013133.2  OTTHUMT00000036814.2   \n",
       "212535            KNOWN  OTTHUMG00000022258.1  OTTHUMT00000058009.1   \n",
       "\n",
       "             ccdsId  level transcriptClass          ensembl  \n",
       "371        CCDS22.1      2          coding  ENSG00000107404  \n",
       "1261            NaN      3          coding  ENSG00000171608  \n",
       "1439            NaN      2          coding  ENSG00000198793  \n",
       "1766            NaN      2          coding  ENSG00000132906  \n",
       "1842            NaN      2       nonCoding  ENSG00000116809  \n",
       "...             ...    ...             ...              ...  \n",
       "209916  CCDS14283.1      2          coding  ENSG00000126767  \n",
       "210910          NaN      3          coding  ENSG00000169083  \n",
       "211060          NaN      2         problem  ENSG00000147168  \n",
       "211423  CCDS75996.1      2          coding  ENSG00000196468  \n",
       "212535  CCDS14573.1      2          coding  ENSG00000131724  \n",
       "\n",
       "[276 rows x 14 columns]"
      ]
     },
     "execution_count": 26,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hugo_to_ens=hugo_to_ens.drop_duplicates(subset='geneName',keep='first')\n",
    "hugo_to_ens"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "id": "1f5f2639",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>ensembl</th>\n",
       "      <th>geneName</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>371</th>\n",
       "      <td>ENSG00000107404</td>\n",
       "      <td>DVL1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1261</th>\n",
       "      <td>ENSG00000171608</td>\n",
       "      <td>PIK3CD</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1439</th>\n",
       "      <td>ENSG00000198793</td>\n",
       "      <td>MTOR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1766</th>\n",
       "      <td>ENSG00000132906</td>\n",
       "      <td>CASP9</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1842</th>\n",
       "      <td>ENSG00000116809</td>\n",
       "      <td>ZBTB17</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>209916</th>\n",
       "      <td>ENSG00000126767</td>\n",
       "      <td>ELK1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>210910</th>\n",
       "      <td>ENSG00000169083</td>\n",
       "      <td>AR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>211060</th>\n",
       "      <td>ENSG00000147168</td>\n",
       "      <td>IL2RG</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>211423</th>\n",
       "      <td>ENSG00000196468</td>\n",
       "      <td>FGF16</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>212535</th>\n",
       "      <td>ENSG00000131724</td>\n",
       "      <td>IL13RA1</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>276 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                ensembl geneName\n",
       "371     ENSG00000107404     DVL1\n",
       "1261    ENSG00000171608   PIK3CD\n",
       "1439    ENSG00000198793     MTOR\n",
       "1766    ENSG00000132906    CASP9\n",
       "1842    ENSG00000116809   ZBTB17\n",
       "...                 ...      ...\n",
       "209916  ENSG00000126767     ELK1\n",
       "210910  ENSG00000169083       AR\n",
       "211060  ENSG00000147168    IL2RG\n",
       "211423  ENSG00000196468    FGF16\n",
       "212535  ENSG00000131724  IL13RA1\n",
       "\n",
       "[276 rows x 2 columns]"
      ]
     },
     "execution_count": 27,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "gene_mapping = hugo_to_ens[['ensembl', 'geneName']]\n",
    "gene_mapping"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 28,
   "id": "a59f0992",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: total: 15.6 ms\n",
      "Wall time: 195 ms\n"
     ]
    }
   ],
   "source": [
    "%%time\n",
    "with pd.HDFStore('data/LUAD/gene_map.h5','w') as store:\n",
    "    store['gene_map']=gene_mapping"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "34adc07a",
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3 (ipykernel)",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.10.4"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 5
}