CANDy v2.0.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "id": "0a250a1b",
   "metadata": {},
   "source": [
    "# Getting started"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "62854253",
   "metadata": {},
   "source": [
    "### Requirements\n",
    "\n",
    "This Notebook uses several Python packages. To avoid compatibility issues we recommend running this Notebook in a __virtual environment__.\n",
    "- Therefore, install [Anaconda](https://www.anaconda.com/) and follow the installation instructions.\n",
    "- Go to 'Environments' in Anaconda and click 'create'. Give your environment a name, for example '__myenv__'. The virual environment will be launched automatically.\n",
    "- Go to the package search bar and search for '__ipywidgets__'. Download the package to be able to use the interactive widgets in this Notebook. Repeat for the '__h5py__' package.\n",
    "- Next, go back to the 'Home' page in Anaconda and install __Jupyter Notebook__. Once completed, press launch and go to the directory where you saved this Notebook. \n",
    "- Verify that you see the name of the virtual enivronment on the right top of the Notebook, for example: __Python (myenv)__. If that's not the case, go to Kernel and choose the environment.\n",
    "\n",
    "The workflow uses several non-Python tools ([CD-HIT](https://academic.oup.com/bioinformatics/article/22/13/1658/194225?login=true), [MAFFT](https://academic.oup.com/nar/article/30/14/3059/2904316?login=true) and [FastTree](https://academic.oup.com/mbe/article/26/7/1641/1128976?login=true)). To use this Notebook to its full strength, make sure to download these packages and compile them according to your system. Installation instructions can be found on the [GitHub](https://github.com/PyEED/CANDy) page. Make sure you have them installed in the same directory as this Notebook before running.\n",
    "\n",
    "### Running CANDy\n",
    "\n",
    "If you wish to analyze bigger CAZy families, avoid your computer entering sleep mode since this will interrupt the script. Do this in the settings of your system or by running __caffeinate__ in your Terminal. "
   ]
  },
  {
   "cell_type": "markdown",
   "id": "1845c518",
   "metadata": {},
   "source": [
    "# Install dependencies"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "id": "19fdc220",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Collecting Bio\n",
      "  Using cached bio-1.6.2-py3-none-any.whl.metadata (5.1 kB)\n",
      "Collecting biopython>=1.80 (from Bio)\n",
      "  Using cached biopython-1.83-cp38-cp38-macosx_10_9_x86_64.whl.metadata (13 kB)\n",
      "Collecting requests (from Bio)\n",
      "  Using cached requests-2.32.3-py3-none-any.whl.metadata (4.6 kB)\n",
      "Collecting tqdm (from Bio)\n",
      "  Using cached tqdm-4.66.4-py3-none-any.whl.metadata (57 kB)\n",
      "Collecting mygene (from Bio)\n",
      "  Using cached mygene-3.2.2-py2.py3-none-any.whl.metadata (10 kB)\n",
      "Collecting pandas (from Bio)\n",
      "  Using cached pandas-2.0.3-cp38-cp38-macosx_10_9_x86_64.whl.metadata (18 kB)\n",
      "Collecting pooch (from Bio)\n",
      "  Using cached pooch-1.8.2-py3-none-any.whl.metadata (10 kB)\n",
      "Collecting gprofiler-official (from Bio)\n",
      "  Using cached gprofiler_official-1.0.0-py3-none-any.whl.metadata (11 kB)\n",
      "Collecting numpy (from biopython>=1.80->Bio)\n",
      "  Using cached numpy-1.24.4-cp38-cp38-macosx_10_9_x86_64.whl.metadata (5.6 kB)\n",
      "Collecting biothings-client>=0.2.6 (from mygene->Bio)\n",
      "  Using cached biothings_client-0.3.1-py2.py3-none-any.whl.metadata (9.8 kB)\n",
      "Collecting python-dateutil>=2.8.2 (from pandas->Bio)\n",
      "  Using cached python_dateutil-2.9.0.post0-py2.py3-none-any.whl.metadata (8.4 kB)\n",
      "Collecting pytz>=2020.1 (from pandas->Bio)\n",
      "  Using cached pytz-2024.1-py2.py3-none-any.whl.metadata (22 kB)\n",
      "Collecting tzdata>=2022.1 (from pandas->Bio)\n",
      "  Using cached tzdata-2024.1-py2.py3-none-any.whl.metadata (1.4 kB)\n",
      "Collecting platformdirs>=2.5.0 (from pooch->Bio)\n",
      "  Using cached platformdirs-4.2.2-py3-none-any.whl.metadata (11 kB)\n",
      "Collecting packaging>=20.0 (from pooch->Bio)\n",
      "  Using cached packaging-24.1-py3-none-any.whl.metadata (3.2 kB)\n",
      "Collecting charset-normalizer<4,>=2 (from requests->Bio)\n",
      "  Using cached charset_normalizer-3.3.2-cp38-cp38-macosx_10_9_x86_64.whl.metadata (33 kB)\n",
      "Collecting idna<4,>=2.5 (from requests->Bio)\n",
      "  Using cached idna-3.7-py3-none-any.whl.metadata (9.9 kB)\n",
      "Collecting urllib3<3,>=1.21.1 (from requests->Bio)\n",
      "  Using cached urllib3-2.2.1-py3-none-any.whl.metadata (6.4 kB)\n",
      "Collecting certifi>=2017.4.17 (from requests->Bio)\n",
      "  Using cached certifi-2024.6.2-py3-none-any.whl.metadata (2.2 kB)\n",
      "Collecting six>=1.5 (from python-dateutil>=2.8.2->pandas->Bio)\n",
      "  Using cached six-1.16.0-py2.py3-none-any.whl.metadata (1.8 kB)\n",
      "Using cached bio-1.6.2-py3-none-any.whl (278 kB)\n",
      "Using cached biopython-1.83-cp38-cp38-macosx_10_9_x86_64.whl (2.7 MB)\n",
      "Using cached gprofiler_official-1.0.0-py3-none-any.whl (9.3 kB)\n",
      "Using cached mygene-3.2.2-py2.py3-none-any.whl (5.4 kB)\n",
      "Using cached pandas-2.0.3-cp38-cp38-macosx_10_9_x86_64.whl (11.7 MB)\n",
      "Using cached pooch-1.8.2-py3-none-any.whl (64 kB)\n",
      "Using cached requests-2.32.3-py3-none-any.whl (64 kB)\n",
      "Using cached tqdm-4.66.4-py3-none-any.whl (78 kB)\n",
      "Using cached biothings_client-0.3.1-py2.py3-none-any.whl (29 kB)\n",
      "Using cached certifi-2024.6.2-py3-none-any.whl (164 kB)\n",
      "Using cached charset_normalizer-3.3.2-cp38-cp38-macosx_10_9_x86_64.whl (121 kB)\n",
      "Using cached idna-3.7-py3-none-any.whl (66 kB)\n",
      "Using cached numpy-1.24.4-cp38-cp38-macosx_10_9_x86_64.whl (19.8 MB)\n",
      "Using cached packaging-24.1-py3-none-any.whl (53 kB)\n",
      "Using cached platformdirs-4.2.2-py3-none-any.whl (18 kB)\n",
      "Using cached python_dateutil-2.9.0.post0-py2.py3-none-any.whl (229 kB)\n",
      "Using cached pytz-2024.1-py2.py3-none-any.whl (505 kB)\n",
      "Using cached tzdata-2024.1-py2.py3-none-any.whl (345 kB)\n",
      "Using cached urllib3-2.2.1-py3-none-any.whl (121 kB)\n",
      "Using cached six-1.16.0-py2.py3-none-any.whl (11 kB)\n",
      "Installing collected packages: pytz, urllib3, tzdata, tqdm, six, platformdirs, packaging, numpy, idna, charset-normalizer, certifi, requests, python-dateutil, biopython, pooch, pandas, gprofiler-official, biothings-client, mygene, Bio\n",
      "\u001b[31mERROR: pip's dependency resolver does not currently take into account all the packages that are installed. This behaviour is the source of the following dependency conflicts.\n",
      "mlflow 2.9.1 requires packaging<24, but you have packaging 24.1 which is incompatible.\n",
      "mlflow 2.9.1 requires pytz<2024, but you have pytz 2024.1 which is incompatible.\n",
      "selenium 4.7.2 requires urllib3[socks]~=1.26, but you have urllib3 2.2.1 which is incompatible.\u001b[0m\u001b[31m\n",
      "\u001b[0mSuccessfully installed Bio-1.6.2 biopython-1.83 biothings-client-0.3.1 certifi-2024.6.2 charset-normalizer-3.3.2 gprofiler-official-1.0.0 idna-3.7 mygene-3.2.2 numpy-1.24.4 packaging-24.1 pandas-2.0.3 platformdirs-4.2.2 pooch-1.8.2 python-dateutil-2.9.0.post0 pytz-2024.1 requests-2.32.3 six-1.16.0 tqdm-4.66.4 tzdata-2024.1 urllib3-2.2.1\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/tqdm-4.66.4.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/packaging already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/tzdata-2024.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/certifi-2024.6.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/Bio already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/gprofiler_official-1.0.0.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/mygene-3.2.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/requests-2.32.3.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/six-1.16.0.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/bio-1.6.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/packaging-24.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/tzdata already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pytz-2024.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/idna already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/biopython-1.83.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pytz already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/numpy already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/charset_normalizer already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/requests already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/gprofiler already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/certifi already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/python_dateutil-2.9.0.post0.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/charset_normalizer-3.3.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pooch already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/urllib3-2.2.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/tqdm already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/numpy-1.24.4.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/six.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/idna-3.7.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pooch-1.8.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/BioSQL already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/urllib3 already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pandas-2.0.3.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/biothings_client already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/biorun already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/platformdirs-4.2.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pandas already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/dateutil already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/mygene already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/platformdirs already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/biothings_client-0.3.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/bin already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\u001b[0mCollecting pandas\n",
      "  Using cached pandas-2.0.3-cp38-cp38-macosx_10_9_x86_64.whl.metadata (18 kB)\n",
      "Collecting python-dateutil>=2.8.2 (from pandas)\n",
      "  Using cached python_dateutil-2.9.0.post0-py2.py3-none-any.whl.metadata (8.4 kB)\n",
      "Collecting pytz>=2020.1 (from pandas)\n",
      "  Using cached pytz-2024.1-py2.py3-none-any.whl.metadata (22 kB)\n",
      "Collecting tzdata>=2022.1 (from pandas)\n",
      "  Using cached tzdata-2024.1-py2.py3-none-any.whl.metadata (1.4 kB)\n",
      "Collecting numpy>=1.20.3 (from pandas)\n",
      "  Using cached numpy-1.24.4-cp38-cp38-macosx_10_9_x86_64.whl.metadata (5.6 kB)\n",
      "Collecting six>=1.5 (from python-dateutil>=2.8.2->pandas)\n",
      "  Using cached six-1.16.0-py2.py3-none-any.whl.metadata (1.8 kB)\n",
      "Using cached pandas-2.0.3-cp38-cp38-macosx_10_9_x86_64.whl (11.7 MB)\n",
      "Using cached numpy-1.24.4-cp38-cp38-macosx_10_9_x86_64.whl (19.8 MB)\n",
      "Using cached python_dateutil-2.9.0.post0-py2.py3-none-any.whl (229 kB)\n",
      "Using cached pytz-2024.1-py2.py3-none-any.whl (505 kB)\n",
      "Using cached tzdata-2024.1-py2.py3-none-any.whl (345 kB)\n",
      "Using cached six-1.16.0-py2.py3-none-any.whl (11 kB)\n",
      "Installing collected packages: pytz, tzdata, six, numpy, python-dateutil, pandas\n",
      "\u001b[31mERROR: pip's dependency resolver does not currently take into account all the packages that are installed. This behaviour is the source of the following dependency conflicts.\n",
      "mlflow 2.9.1 requires pytz<2024, but you have pytz 2024.1 which is incompatible.\u001b[0m\u001b[31m\n",
      "\u001b[0mSuccessfully installed numpy-1.24.4 pandas-2.0.3 python-dateutil-2.9.0.post0 pytz-2024.1 six-1.16.0 tzdata-2024.1\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/tzdata-2024.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/six-1.16.0.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/tzdata already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pytz-2024.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pytz already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/numpy already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/python_dateutil-2.9.0.post0.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/numpy-1.24.4.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/six.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pandas-2.0.3.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/pandas already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/dateutil already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/bin already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0mCollecting requests\n",
      "  Using cached requests-2.32.3-py3-none-any.whl.metadata (4.6 kB)\n",
      "Collecting charset-normalizer<4,>=2 (from requests)\n",
      "  Using cached charset_normalizer-3.3.2-cp38-cp38-macosx_10_9_x86_64.whl.metadata (33 kB)\n",
      "Collecting idna<4,>=2.5 (from requests)\n",
      "  Using cached idna-3.7-py3-none-any.whl.metadata (9.9 kB)\n",
      "Collecting urllib3<3,>=1.21.1 (from requests)\n",
      "  Using cached urllib3-2.2.1-py3-none-any.whl.metadata (6.4 kB)\n",
      "Collecting certifi>=2017.4.17 (from requests)\n",
      "  Using cached certifi-2024.6.2-py3-none-any.whl.metadata (2.2 kB)\n",
      "Using cached requests-2.32.3-py3-none-any.whl (64 kB)\n",
      "Using cached certifi-2024.6.2-py3-none-any.whl (164 kB)\n",
      "Using cached charset_normalizer-3.3.2-cp38-cp38-macosx_10_9_x86_64.whl (121 kB)\n",
      "Using cached idna-3.7-py3-none-any.whl (66 kB)\n",
      "Using cached urllib3-2.2.1-py3-none-any.whl (121 kB)\n",
      "Installing collected packages: urllib3, idna, charset-normalizer, certifi, requests\n",
      "\u001b[31mERROR: pip's dependency resolver does not currently take into account all the packages that are installed. This behaviour is the source of the following dependency conflicts.\n",
      "bio 1.5.2 requires biopython==1.79, but you have biopython 1.81 which is incompatible.\n",
      "selenium 4.7.2 requires urllib3[socks]~=1.26, but you have urllib3 2.2.1 which is incompatible.\u001b[0m\u001b[31m\n",
      "\u001b[0mSuccessfully installed certifi-2024.6.2 charset-normalizer-3.3.2 idna-3.7 requests-2.32.3 urllib3-2.2.1\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/certifi-2024.6.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/requests-2.32.3.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/idna already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/charset_normalizer already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/requests already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/certifi already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/charset_normalizer-3.3.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/urllib3-2.2.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/idna-3.7.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/urllib3 already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/bin already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0mCollecting ete3\n",
      "  Using cached ete3-3.1.3-py3-none-any.whl\n",
      "Installing collected packages: ete3\n",
      "Successfully installed ete3-3.1.3\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/ete3 already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/ete3-3.1.3.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/ete3 already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/bin already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\u001b[0mCollecting biopython\n",
      "  Using cached biopython-1.83-cp38-cp38-macosx_10_9_x86_64.whl.metadata (13 kB)\n",
      "Collecting numpy (from biopython)\n",
      "  Using cached numpy-1.24.4-cp38-cp38-macosx_10_9_x86_64.whl.metadata (5.6 kB)\n",
      "Using cached biopython-1.83-cp38-cp38-macosx_10_9_x86_64.whl (2.7 MB)\n",
      "Using cached numpy-1.24.4-cp38-cp38-macosx_10_9_x86_64.whl (19.8 MB)\n",
      "Installing collected packages: numpy, biopython\n",
      "\u001b[31mERROR: pip's dependency resolver does not currently take into account all the packages that are installed. This behaviour is the source of the following dependency conflicts.\n",
      "bio 1.5.2 requires biopython==1.79, but you have biopython 1.83 which is incompatible.\u001b[0m\u001b[31m\n",
      "\u001b[0mSuccessfully installed biopython-1.83 numpy-1.24.4\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/Bio already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/biopython-1.83.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/numpy already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/numpy-1.24.4.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/BioSQL already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/bin already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0mCollecting db-sqlite3\n",
      "  Using cached db_sqlite3-0.0.1-py3-none-any.whl\n",
      "Collecting db (from db-sqlite3)\n",
      "  Using cached db-0.1.1-py3-none-any.whl\n",
      "Collecting antiorm (from db->db-sqlite3)\n",
      "  Using cached antiorm-1.2.1-py3-none-any.whl\n",
      "Installing collected packages: antiorm, db, db-sqlite3\n",
      "Successfully installed antiorm-1.2.1 db-0.1.1 db-sqlite3-0.0.1\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/antiorm-1.2.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/antipool.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/db_sqlite3.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/db-0.1.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/db_sqlite3-0.0.1.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/dbapiext.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/antiorm.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/dbrelmgr.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/db already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0mCollecting SQLAlchemy\n",
      "  Using cached SQLAlchemy-2.0.30-cp38-cp38-macosx_10_9_x86_64.whl.metadata (9.6 kB)\n",
      "Collecting typing-extensions>=4.6.0 (from SQLAlchemy)\n",
      "  Using cached typing_extensions-4.12.2-py3-none-any.whl.metadata (3.0 kB)\n",
      "Collecting greenlet!=0.4.17 (from SQLAlchemy)\n",
      "  Using cached greenlet-3.0.3-cp38-cp38-macosx_11_0_universal2.whl.metadata (3.8 kB)\n",
      "Using cached SQLAlchemy-2.0.30-cp38-cp38-macosx_10_9_x86_64.whl (2.1 MB)\n",
      "Using cached greenlet-3.0.3-cp38-cp38-macosx_11_0_universal2.whl (269 kB)\n",
      "Using cached typing_extensions-4.12.2-py3-none-any.whl (37 kB)\n",
      "Installing collected packages: typing-extensions, greenlet, SQLAlchemy\n",
      "Successfully installed SQLAlchemy-2.0.30 greenlet-3.0.3 typing-extensions-4.12.2\n",
      "\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/sqlalchemy already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/SQLAlchemy-2.0.30.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/greenlet-3.0.3.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/typing_extensions-4.12.2.dist-info already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/greenlet already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/typing_extensions.py already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m\u001b[33mWARNING: Target directory /Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/site_packages_dir/include already exists. Specify --upgrade to force replacement.\u001b[0m\u001b[33m\n",
      "\u001b[0m"
     ]
    }
   ],
   "source": [
    "import site\n",
    "import sys\n",
    "\n",
    "site_packages_dir = site.getsitepackages()[0]\n",
    "\n",
    "!pip3 install Bio --target site_packages_dir\n",
    "!pip3 install pandas --target site_packages_dir\n",
    "!pip3 install requests --target site_packages_dir\n",
    "!pip3 install ete3 --target site_packages_dir\n",
    "!pip3 install biopython --target site_packages_dir\n",
    "!pip3 install db-sqlite3 --target site_packages_dir\n",
    "!pip3 install SQLAlchemy --target site_packages_dir\n",
    "    \n",
    "go = False"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "1fd1bdef",
   "metadata": {},
   "source": [
    "# Input options"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "99d2b3db",
   "metadata": {},
   "source": [
    "### CAZy family\n",
    "\n",
    "Pick the CAZy enzyme class and family (and subfamily) you want to analyze from the dropdown menu.\n",
    "\n",
    "### Taxonomy selection\n",
    "\n",
    "If desired, you can perform the actual analysis for a taxonomic subset of the chosen CAZy family (Archaea, Bacteria, Eukaryota, Viruses, Unclassified). \n",
    "\n",
    "### Clustering\n",
    "\n",
    "For a large number of sequences, it is useful to perform a clustering step (CD-HIT). This can significantly reduce the number of input sequences and thus speed up the process. Since CANDy focusses on the occurence of entire protein domains, the clustering cut-off can be set quite low (default: 0.85). \n",
    "\n",
    "### Curation\n",
    "\n",
    "An iterative cleaning step to remove overlapping domains and low quality annotations is done. To improve performance, a max expected domain length can be set (default 800 AA). This way any erronous annotations can be avoided. For small proteins, this value can decreased.\n",
    "\n",
    "### Visualization\n",
    "\n",
    "The found domain architectures can be viualized on a phylogenetic tree, which can be useful for further analysis. When chosen 'Yes' in the dropdown menu, a MSA (MAFFT) and PTI (FastTree) step is performed. This generates a tree file in .nwk format and an [iTOL](https://itol.embl.de/) annotation file containing the domain reprentation of each protein.    \n",
    "\n",
    "\n",
    "### Option 1: Run only the following cell to choose from the input options (or skip to cell 3 to use an input FASTA file instead):"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 40,
   "id": "feb38f0b",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Enter your e-mail adress: alex.windels@ugent.be\n",
      "Jobname: GH173_clustering_test\n"
     ]
    },
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "611c1f501c76431fa1dd7ac99c8ae7ce",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "VBox(children=(Label(value='Choose the enzyme class: '), Dropdown(options=(('', ''), ('Glycoside hydrolases', …"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "import ipywidgets as widgets\n",
    "from ipywidgets import HBox, VBox, Label, IntSlider\n",
    "\n",
    "\n",
    "ECdropdown = widgets.Dropdown(\n",
    "    options = [(\"\", \"\"), (\"Glycoside hydrolases\", \"GH\"), (\"Glycosyl transferases\", \"GT\"), (\"Polysaccharide lyases\", \"PL\"), (\"Carbohydrate esterases\", \"CE\"), (\"Auxiliary activities\", \"AA\")])\n",
    "\n",
    "famsize = {\"GH\":183, \"GT\": 116, \"PL\": 42, \"CE\": 20, \"AA\": 17}\n",
    "\n",
    "subfamilies = {'GH5': ['1', '2', '4', '5', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21', '22', '23', '24', '25', '26', '27', '28', '29', '30', '31', '32', '33', '34', '35', '36', '37', '38', '39', '40', '41', '42', '43', '44', '45', '46', '47', '48', '49', '50', '51', '52', '53', '54', '55', '56', '57'],\n",
    "'GH13': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21', '22', '23', '24', '25', '26', '27', '28', '29', '30', '31', '32', '33', '34', '35', '36', '37', '38', '39', '40', '41', '42', '43', '44', '45', '46'],\n",
    "'GH16': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21', '22', '23', '24', '25', '26', '27'],\n",
    "'GH19': ['1', '2'],\n",
    "'GH30': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10'],\n",
    "'GH31': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20'],\n",
    "'GH43': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17', '18', '19', '20', '21', '22', '23', '24', '25', '26', '27', '28', '29', '30', '31', '32', '33', '34', '35', '36', '37', '39'],\n",
    "'GH45': ['1', '2', '3', '4'],\n",
    "'GH51': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14'],\n",
    "'GH55': ['1', '2', '3'],\n",
    "'GH68': ['1', '2'],\n",
    "'GH130': ['1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16']}\n",
    "\n",
    "famdropdown = widgets.Dropdown()\n",
    "\n",
    "subfamdropdown = widgets.Dropdown()\n",
    "\n",
    "taxdropdown =  widgets.Dropdown(\n",
    "    options = [(\"All\", \"All\"), (\"Archaea\", \"A\"), (\"Bacteria\", \"B\"), (\"Eukaryota\", \"E\"), (\"Viruses\", \"V\"), (\"Unclassified\", \"U\")])\n",
    "\n",
    "clustervalue = IntSlider(min=0, max=100, step=1, value=85)\n",
    "blastidentityvalue = IntSlider(min=0, max=100, step=1, value=95)\n",
    "overlap_percentage = IntSlider(min=0, max=100, step=1, value=31)\n",
    "aS_percentage = IntSlider(min=0, max=100, step=1, value=0)\n",
    "aL_percentage = IntSlider(min=0, max=100, step=1, value=0)\n",
    "max_domainlengthvalue = IntSlider(min=10, max=1500, step=1, value=800)\n",
    "\n",
    "treedropdown = widgets.Dropdown(options = [(\"No\", False), (\"Yes\", True)])\n",
    "\n",
    "\n",
    "# Define a function to update the options of dropdown2 based on the selected value of dropdown1\n",
    "def update_dropdown2_options(change):\n",
    "    famdropdown.options = [i for i in range(1, famsize[change.new] + 1)]\n",
    "    \n",
    "# Use the observe method of dropdown1 to observe changes to its value and update the options of dropdown2 accordingly\n",
    "ECdropdown.observe(update_dropdown2_options, names='value')\n",
    "\n",
    "family = str(ECdropdown.value) + str(famdropdown.label)\n",
    "\n",
    "def update_dropdown3_options(change):\n",
    "    family = str(ECdropdown.value) + str(change.new)\n",
    "    subfamdropdown.options = ['N.a.']\n",
    "    if family in subfamilies:\n",
    "        subfamdropdown.options += tuple(subfamilies[family])\n",
    "    \n",
    "    \n",
    "famdropdown.observe(update_dropdown3_options, names='value')\n",
    "\n",
    "#print('Enter your e-mail adress: ')\n",
    "email = input('Enter your e-mail adress: ')\n",
    "basejobname = input('Jobname: ')\n",
    "\n",
    "#display the dropdown widgets\n",
    "VBox([Label(\"Choose the enzyme class: \"), ECdropdown, \n",
    "      Label(\"Choose the family number: \"), famdropdown,\n",
    "      Label(\"Choose the subfamily (if applicable): \"), subfamdropdown,\n",
    "      Label(\"Choose a taxonomy subset: \"), taxdropdown,\n",
    "      Label(\"Choose a clustering cut-off (%): \"), clustervalue,\n",
    "      Label(\"Choose a clustering cut-off (%) in the case of a characterized protein BLAST search: \"), blastidentityvalue,\n",
    "      Label(\"Choose a cut-off (%) for which overlapping annotations are considered to be the same: \"), overlap_percentage,\n",
    "      Label(\"Indicate the minimal coverage for the shorter sequence when clustering (%): \"), aS_percentage,\n",
    "      Label(\"Indicate the minimal coverage for the shorter sequence when clustering (%): \"), aL_percentage,\n",
    "      Label(\"Choose a max expected domain size (AA): \"), max_domainlengthvalue,\n",
    "      Label(\"Do you wish to construct a phylogenetic tree? \"), treedropdown])\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "68e4bddf",
   "metadata": {},
   "source": [
    "### Save the queries and innitiate CANDy by hitting Cell -> Execute everything below"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 41,
   "id": "d4221231",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Input summary \n",
      " \n",
      " - Chosen CAZy family: GH173 \n",
      " - Taxonomy subset: All \n",
      " - Clustering cut-off: 85 \n",
      " - BLAST identity treshold: 95 \n",
      " - Max domain length: 800 \n",
      " - Phylogenetic tree construction: Yes \n"
     ]
    }
   ],
   "source": [
    "import os\n",
    "import re\n",
    "\n",
    "family = str(ECdropdown.value) + str(famdropdown.label) + '_' + str(subfamdropdown.label)\n",
    "family = family.strip('_N.a.')\n",
    "taxsubset = taxdropdown.label\n",
    "taxsubsetvalue = taxdropdown.value\n",
    "clustercutoff = clustervalue.value\n",
    "blastidentitycutoff = blastidentityvalue.value\n",
    "overlap_percentagecutoff = overlap_percentage.value\n",
    "aS_percentage_value = aS_percentage.value\n",
    "aL_percentage_value = aL_percentage.value\n",
    "max_domainlength = max_domainlengthvalue.value\n",
    "treeconstruction = treedropdown.label\n",
    "execute = treedropdown.value\n",
    "\n",
    "print(f\"Input summary \\n \\n - Chosen CAZy family: {family} \\n - Taxonomy subset: {taxsubset} \\n - Clustering cut-off: {clustercutoff} \\n - BLAST identity treshold: {blastidentitycutoff} \\n - Max domain length: {max_domainlength} \\n - Phylogenetic tree construction: {treeconstruction} \")\n",
    "\n",
    "\n",
    "basejobname = \"\".join(basejobname.split())\n",
    "#replaces any non-alphanumeric character\n",
    "basejobname = re.sub(r'\\W+', '', basejobname)\n",
    "jobname = basejobname \n",
    "\n",
    "#check if directory with jobname exists\n",
    "def check(folder):\n",
    "    if os.path.exists(folder):\n",
    "        return False\n",
    "    else:\n",
    "        return True\n",
    "    \n",
    "if not check(jobname):\n",
    "    n = 0\n",
    "    while not check(f\"{basejobname}_{n}\"): \n",
    "        n += 1\n",
    "    jobname = f\"{basejobname}_{n}\"\n",
    "    \n",
    "# make directory to save results\n",
    "os.makedirs(jobname, exist_ok=True)\n",
    "\n",
    "# save queries\n",
    "queries_path = os.path.join(jobname, f\"{jobname}.csv\")\n",
    "\n",
    "with open(queries_path, \"w\") as text_file:\n",
    "    text_file.write(f\"Jobname,Family,Taxonomy subset,Clustering cut-off, BLAST identity, Overlap percentage, aL coverage (clustering), aS coverage (clustering), Max domain length, Phylogenetic analysis\\n{jobname},{family}, {taxsubset}, {clustercutoff}, {blastidentitycutoff}, {overlap_percentage}, {aS_percentage_value}, {aL_percentage_value}, {max_domainlength}, {treeconstruction}\")\n",
    "\n",
    "if family != 'one_None':\n",
    "    go = True"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "42d7df21",
   "metadata": {},
   "source": [
    "### Option 2: Copy the path of your input FASTA file containing custom sequences"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 42,
   "id": "ef8c1a30",
   "metadata": {},
   "outputs": [],
   "source": [
    "import ipywidgets as widgets\n",
    "from ipywidgets import HBox, VBox, Label, IntSlider\n",
    "\n",
    "inputfile_path = \"/Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/test_fasta_file.fasta\"\n",
    "    \n",
    "if go == False: \n",
    "\n",
    "\n",
    "\n",
    "    max_domainlengthvalue = IntSlider(min=10, max=1500, step=1, value=800)\n",
    "    overlap_percentage = IntSlider(min=0, max=100, step=1, value=31)\n",
    "    aS_percentage = IntSlider(min=0, max=100, step=1, value=0)\n",
    "    aL_percentage = IntSlider(min=0, max=100, step=1, value=0)\n",
    "    treedropdown = widgets.Dropdown(options = [(\"No\", False), (\"Yes\", True)])\n",
    "\n",
    "    #display the dropdown widgets\n",
    "    display(VBox([Label(\"Choose a max expected domain size (AA): \"), max_domainlengthvalue,\n",
    "                  Label(\"Choose a cut-off (%) for which overlapping annotations are considered to be the same: \"),overlap_percentage,\n",
    "                  Label(\"Indicate the minimal coverage for the shorter sequence when clustering (%): \"), aS_percentage,\n",
    "                  Label(\"Indicate the minimal coverage for the shorter sequence when clustering (%): \"), aL_percentage,\n",
    "                  Label(\"Do you wish to construct a phylogenetic tree? \"), treedropdown]))\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "6160be67",
   "metadata": {},
   "source": [
    "### Initiate CANDy by hitting Cell -> Execute everything below"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 43,
   "id": "c7a2fe55",
   "metadata": {},
   "outputs": [],
   "source": [
    "import os\n",
    "\n",
    "max_domainlength = max_domainlengthvalue.value\n",
    "overlap_percentagecutoff = overlap_percentage.value\n",
    "aS_percentage_value = aS_percentage.value\n",
    "aL_percentage_value = aL_percentage.value\n",
    "treeconstruction = treedropdown.label\n",
    "execute = treedropdown.value\n",
    "\n",
    "\n",
    "def is_fasta(filename, go = False):\n",
    "    \"\"\"\n",
    "    Check if a file is in FASTA format.\n",
    "\n",
    "    Args:\n",
    "    filename (str): The name of the file to check.\n",
    "\n",
    "    Returns:\n",
    "    bool: True if the file is in FASTA format, False otherwise.\n",
    "    \"\"\"\n",
    "    with open(filename, 'r') as file:\n",
    "        # Read the first line\n",
    "        first_line = file.readline().strip()\n",
    "        \n",
    "        # Check if the first line starts with '>'\n",
    "        if first_line.startswith('>'):\n",
    "            return True\n",
    "        else:\n",
    "            return False\n",
    "\n",
    "\n",
    "\n",
    "if go == False:\n",
    "    jobname = inputfile_path.split('/')[-1].split('.')[0]\n",
    "    #check if directory with jobname exists\n",
    "    \n",
    "    if is_fasta(inputfile_path, go):\n",
    "        print(f\"{inputfile_path} is in FASTA format.\")\n",
    "    else:\n",
    "        print(f\"WARNING {inputfile_path} is not in FASTA format.\")\n",
    "    \n",
    "    def check(folder):\n",
    "        if os.path.exists(folder):\n",
    "            return False\n",
    "        else:\n",
    "            return True\n",
    "\n",
    "    if not check(jobname):\n",
    "        n = 0\n",
    "        while not check(f\"{jobname}_{n}\"): \n",
    "            n += 1\n",
    "        jobname = f\"{jobname}_{n}\"\n",
    "\n",
    "    # make directory to save results\n",
    "    os.makedirs(jobname, exist_ok=True)\n",
    "\n",
    "    # save queries\n",
    "    queries_path = os.path.join(jobname, f\"{jobname}.csv\")\n",
    "\n",
    "    with open(queries_path, \"w\") as text_file:\n",
    "        text_file.write(f\"Jobname,F Max domain length, Overlap percentage, aS coverage (clustering), aL coverage (clustering), Phylogenetic analysis\\n{jobname}, {max_domainlength}, {overlap_percentage}, {aS_percentage_value}, {aL_percentage_value}, {treeconstruction}\")"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "3edfa400",
   "metadata": {},
   "source": [
    "# Generic functions"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 44,
   "id": "87a7bd0d",
   "metadata": {},
   "outputs": [],
   "source": [
    "def sizefastafile (inputfile):\n",
    "    \"\"\"Count the number of protein sequences in a given fasta file\"\"\"\n",
    "    with open (inputfile) as file:\n",
    "        size = 0\n",
    "        for line in file:\n",
    "            if line.startswith(\">\"):\n",
    "                size += 1\n",
    "                \n",
    "    return size"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "f94eaf9a",
   "metadata": {},
   "source": [
    "# Extract CAZy family sequences"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 45,
   "id": "771e8274",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import the necessary modules\n",
    "\n",
    "import pandas as pd\n",
    "import requests\n",
    "import Bio\n",
    "from Bio import Entrez\n",
    "from Bio import SeqIO\n",
    "from urllib.request import HTTPError\n",
    "from tqdm import tqdm\n",
    "from time import sleep\n",
    "\n",
    "if go:\n",
    "    Entrez.email = email\n",
    "\n",
    "#pandas configuration\n",
    "pd.set_option('display.max_rows', None)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 46,
   "id": "f1718e9d",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Working on family GH173.\n",
      "Retrieving data from page http://www.cazy.org/IMG/cazy_data/GH173.txt\n",
      "Writing the GH173 CAZy data file.\n",
      "Taxonomydict written.\n",
      "Writing the GH173 GenBank ID file.\n",
      "Extracting protein sequences from NCBI.\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "100%|█████████████████████████████████████████| 185/185 [03:10<00:00,  1.03s/it]"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Writing GH173_All FASTA sequences file.\n",
      "Finished!\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "\n"
     ]
    }
   ],
   "source": [
    "#script\n",
    "\n",
    "def CAZy_extract(family, data, taxsubset):\n",
    "    \"\"\"This function extracts the GenBank IDs from a CAZy family and builds a FASTA file with corresponding protein\n",
    "    sequences\"\"\"\n",
    "    \n",
    "    print(f'Writing the {family} CAZy data file.')\n",
    "    \n",
    "    #write the CAZy ouput to a file\n",
    "    with open(os.path.join(jobname, f\"CAZy_data_{family}.txt\"),'w') as file:\n",
    "        file.write(data)\n",
    "    \n",
    "    #this is the dataframe\n",
    "    df = pd.read_table(os.path.join(jobname, f\"CAZy_data_{family}.txt\"),engine = 'python', header=None)\n",
    "    \n",
    "    #Let's shorten the Taxonomy description\n",
    "    tax_dict = {'BACTERIA': 'B', 'EUKARYOTA': 'E', 'ARCHAEA': 'A', 'VIRUSES': 'V', 'UNCLASSIFIED': 'U'}\n",
    "    \n",
    "    #Create a dictionary with the identifiers as keys and the kingdom as value, e.g., AW1234:E\n",
    "    taxonomydict = {}\n",
    "    \n",
    "    \n",
    "    #go over each row in the df\n",
    "    for index, line in df.iterrows():\n",
    "        \n",
    "        #the kingdom of this identifier is at position 1\n",
    "        tax = line[1].upper()\n",
    "        \n",
    "        #the identifier is at position 3\n",
    "        ID = line[3]\n",
    "        \n",
    "        #build the taxonomydict\n",
    "        taxonomydict[ID] = tax_dict[tax]\n",
    "        \n",
    "     \n",
    "    with open(os.path.join(jobname, f\"Taxonomydict_CAZy_{family}.txt\"), 'w') as file:\n",
    "        file.write(str(taxonomydict))\n",
    "        print('Taxonomydict written.')\n",
    "        \n",
    "    #check whether there exist sequences belongling to the chosen taxonomy subset\n",
    "    if taxsubset != 'All' and tax_dict[taxsubset.upper()] not in taxonomydict.values():\n",
    "        print(f'WARNING: Sorry, no sequences belonging to {taxsubset} have been found. Please change your selection at the input options and restart CANDy')\n",
    "        #stop the function\n",
    "        return \n",
    "        \n",
    "    ncbi_vs_jgi = df.iloc[:,-1]\n",
    "    length = len(ncbi_vs_jgi)\n",
    "    desired_indices = []\n",
    "    for i in range(0,length,1):\n",
    "        if str(ncbi_vs_jgi.iloc[i]) == 'ncbi':\n",
    "            desired_indices.append(i)\n",
    "\n",
    "    df = df.iloc[:,-2]\n",
    "    df = df.iloc[desired_indices]\n",
    "    #print(df)\n",
    "    #write the ID's to a separate file\n",
    "    #df = df[3]\n",
    "    output = df.to_string(index=False)\n",
    "\n",
    "    \n",
    "    print(f'Writing the {family} GenBank ID file.')\n",
    "    with open(os.path.join(jobname, f\"CAZy_{family}_GenBankIDs.txt\"), 'w') as file:\n",
    "        file.write(output)\n",
    "        \n",
    "    with open(os.path.join(jobname, f\"CAZy_{family}_GenBankIDs.txt\"), 'r') as file:\n",
    "        total_length = len(file.readlines()) #can't be integrated in the next lines: tqdm(file, total) because files gets closed\n",
    "\n",
    "    print(f'Extracting protein sequences from NCBI.')\n",
    "    \n",
    "    #fetch the protein sequences using Entrez.efetch\n",
    "    fastasequences = ''\n",
    "    with open(os.path.join(jobname, f\"CAZy_{family}_GenBankIDs.txt\"), 'r') as file:\n",
    "        for line in tqdm(file, total = total_length):\n",
    "            \n",
    "            #take into account the selected taxonomic subset\n",
    "            if taxonomydict[line.strip()] == taxsubsetvalue if taxsubsetvalue != 'All' else (True):\n",
    "                attempts = 0\n",
    "\n",
    "                #during peak hours, a HTTP out error may occur. Try 10 times untill going to the next ID\n",
    "                while attempts < 10:\n",
    "                    try:\n",
    "\n",
    "                        #fetch the sequences\n",
    "                        handle = Entrez.efetch(\"Protein\", id = line, retmode = \"text\", rettype = \"fasta\")\n",
    "                        try:\n",
    "                            seq_record = SeqIO.read(handle, \"fasta\")\n",
    "                        except:\n",
    "                            print(\"Something went wrong, let's skip this one.\")\n",
    "                            continue  # Something went wrong retrieving data\n",
    "\n",
    "                        thisoutput = \">\"+seq_record.description+\"\\n\"+str(seq_record.seq)+\"\\n\"\n",
    "                        fastasequences = fastasequences + thisoutput\n",
    "                        handle.close()\n",
    "                        break\n",
    "\n",
    "                    except HTTPError:\n",
    "                        #HTTP Error. Let's try waiting for a little bit\n",
    "                        attempts += 1\n",
    "                        sleep(3)\n",
    "\n",
    "    return fastasequences, taxonomydict\n",
    "\n",
    "\n",
    "\n",
    "if go == True:\n",
    "    print(f'Working on family {family}.')\n",
    "    #url\n",
    "    url = 'http://www.cazy.org/IMG/cazy_data/'+family+'.txt'\n",
    "    print(f'Retrieving data from page {url}')\n",
    "    response = requests.get(url)\n",
    "    data = response.text\n",
    "\n",
    "    #extract GenBank ID's from this page\n",
    "\n",
    "    sequence_extraction = CAZy_extract(family,data, taxsubset)\n",
    "    result = sequence_extraction[0]\n",
    "    taxonomydict = sequence_extraction[1]\n",
    "\n",
    "    print(f'Writing {family}_{taxsubset} FASTA sequences file.')\n",
    "    with open(os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_FASTA_sequences.fasta\"),'w') as file:\n",
    "        file.write(result)\n",
    "\n",
    "\n",
    "    print('Finished!')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "00f27039",
   "metadata": {},
   "source": [
    "# Exclude sequences not available in UniParc\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 47,
   "id": "4dc41f8b",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import necessary modules\n",
    "import hashlib\n",
    "import urllib\n",
    "import sys\n",
    "import xml.etree.ElementTree as ET\n",
    "from urllib.parse import urlencode\n",
    "from urllib.request import urlopen\n",
    "import time\n",
    "import numpy as np\n",
    "\n",
    "if go == True:\n",
    "    #inputfile\n",
    "    inputfile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_FASTA_sequences.fasta\")\n",
    "\n",
    "    #outputfile\n",
    "    outputfile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_Verified_FASTA_sequences.fasta\")\n",
    "\n",
    "    #API url\n",
    "    URL = \"https://www.ebi.ac.uk/interpro/match-lookup/matches\""
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 48,
   "id": "52a4a1d0",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Checking UniParc ID's.\n",
      "180 out of 185 sequences will be included.\n",
      "5 sequences can not be found in UniParc and will be excluded. \n",
      "\n",
      "0 partial sequences in this family. They are removed from the analysis.\n"
     ]
    }
   ],
   "source": [
    "#Here we generate a file only containing UNIQUE and complete sequences that can be used for InterPro domain detection\n",
    "def parse_fasta(inputfile):\n",
    "    \"\"\"This function parses trough a given FASTA file and creates a dict of ID: sequence\"\"\"\n",
    "    proteins = {}\n",
    "    \n",
    "    with open(inputfile, 'r') as file:\n",
    "        count = 0\n",
    "        for seq_record in SeqIO.parse(file, \"fasta\"):\n",
    "            proteins[seq_record.id] = str(seq_record.seq)\n",
    "            count += 1\n",
    "            \n",
    "    return proteins\n",
    "\n",
    "def split_dict(dictionary, n):\n",
    "    dict_list = np.array_split(list(dictionary.items()), n)\n",
    "    return [dict(item) for item in dict_list]\n",
    "\n",
    "def check_uniparc(proteins, print_output = True):\n",
    "    \"\"\"This function checks which sequences have a UniParc ID and thus can be used for InterPro domain detection\"\"\"\n",
    "    \n",
    "    md5_to_id = {}\n",
    "    print(\"Checking UniParc ID's.\")\n",
    "    #converts the protein sequences to a hexadecimal representation in uppercase\n",
    "    for identifier, sequence in proteins.items():\n",
    "        md5 = hashlib.md5(sequence.encode()).hexdigest().upper()\n",
    "        #if the sequences are 100% identical the old identifier gets removed... \n",
    "        if md5 not in md5_to_id:\n",
    "            md5_to_id[md5] = identifier\n",
    "        else:\n",
    "            md5_to_id[md5] += ' ' + identifier\n",
    "    \n",
    "    #print(md5_to_id)\n",
    "    md5_to_id_len = len(md5_to_id)   \n",
    "    \n",
    "    if md5_to_id_len > 5000:\n",
    "        div = md5_to_id_len//5000 #we want to send the sequences in packages of 5000\n",
    "        md5_to_id_list = split_dict(md5_to_id, div) #this will return a list of dictionaries\n",
    "        \n",
    "    else:\n",
    "        md5_to_id_list = [md5_to_id]\n",
    "    \n",
    "    domain_ids = []\n",
    "    unknown_ids = []\n",
    "    \n",
    "    for subdictionary in md5_to_id_list:\n",
    "        \n",
    "        attempts = 0\n",
    "        \n",
    "        #params is a dictionary that contains all the sequences in hexadecimal representation\n",
    "        params = {\"md5\": list(subdictionary.keys())}\n",
    "        #print(params)\n",
    "        data = urlencode(params, doseq=True).encode(\"ascii\")\n",
    "        #print(data)\n",
    "    \n",
    "        #while attempts < 10:\n",
    "        while True:\n",
    "            try:\n",
    "                with urlopen(URL, data) as res:\n",
    "                    data = res.read().decode(\"utf-8\")\n",
    "                    break\n",
    "                \n",
    "            except urllib.error.HTTPError as e:\n",
    "                attempts += 1\n",
    "                print('Retrying in 5 seconds.')\n",
    "                time.sleep(5)\n",
    "            \n",
    "\n",
    "        root = ET.fromstring(data)\n",
    "        for m in root.findall(\".//match\"):\n",
    "            md5 = m.find(\"proteinMD5\").text\n",
    "        \n",
    "            #The pop() method removes the item at the given index from the list and returns the removed item\n",
    "            protein_id = subdictionary.pop(md5) \n",
    "        \n",
    "            for identifier in protein_id.split(' '):\n",
    "                domain_ids.append(identifier)\n",
    "\n",
    "\n",
    "        for protein_id in subdictionary.values():\n",
    "            \n",
    "            #for these sequences no match could be found\n",
    "            for identifier in protein_id.split(' '):\n",
    "                unknown_ids.append(identifier)\n",
    "                \n",
    "    if print_output: \n",
    "        print(f'{len(domain_ids)} out of {len(domain_ids) + len(unknown_ids)} sequences will be included.')\n",
    "        print(f'{len(unknown_ids)} sequences can not be found in UniParc and will be excluded. \\n' )\n",
    "    return domain_ids, unknown_ids\n",
    "\n",
    "def verified_sequences(domain_ids, inputfile):\n",
    "    output = ''\n",
    "    partialcount = 0\n",
    "\n",
    "    with open(inputfile, 'r') as file:\n",
    "        for seq_record in SeqIO.parse(file, \"fasta\"):\n",
    "\n",
    "            if str(seq_record.id) in domain_ids and 'partial' not in seq_record.description:\n",
    "                output += '>' + str(seq_record.description) + '\\n' + str(seq_record.seq) + '\\n'\n",
    "           \n",
    "            elif 'partial' in seq_record.description:\n",
    "                partialcount += 1\n",
    "                \n",
    "    with open (outputfile, 'w') as f:\n",
    "        f.write(output)\n",
    "\n",
    "    print(f'{partialcount} partial sequences in this family. They are removed from the analysis.')\n",
    "    return output\n",
    "\n",
    "if go == True:\n",
    "    uniparccheck = check_uniparc(parse_fasta(inputfile))\n",
    "    verseq = verified_sequences(uniparccheck[0], inputfile)\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "e55ad44d",
   "metadata": {},
   "source": [
    "# Format FASTA file"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 49,
   "id": "6ec3827f",
   "metadata": {},
   "outputs": [],
   "source": [
    "# DESCRIPTION A fasta file will be formatted to remove duplicate sequences, and to remove duplicate identifiers.\n",
    "\n",
    "# EXAMPLES\n",
    "# >gi|2660639|emb|CAA04523.1| alpha-glucan phosphorylase [Thermotoga maritima]\n",
    "# will be changed to\n",
    "# >2660639\n",
    "# \n",
    "# >gi|754097242|ref|WP_041736169.1| alpha-glucan phosphorylase [Coprothermobacter proteolyticus] >gi|639380266|gb|ACI17870.2| alpha-glucan phosphorylase [Coprothermobacter proteolyticus DSM 5265]\n",
    "# will be changed to\n",
    "# >754097242\n",
    "# \n",
    "# And if multiple identifiers contain the exact same sequence, only one is retained.\n",
    "\n",
    "import ast\n",
    "\n",
    "if go == True:\n",
    "    # Route to the fasta files\n",
    "    fastafile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_Verified_FASTA_sequences.fasta\")\n",
    "    outputfile_name = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_FASTA_sequences_formatted.fasta\")\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 50,
   "id": "6f506853",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n",
      "136 unique sequences were obtained after formatting.\n",
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "def format_fasta(fastafile, taxsubsetvalue):\n",
    "    \"\"\"This function file formats an input fasta file to detelete the description \n",
    "    and special characters in the header\"\"\"\n",
    "\n",
    "    sequence_list = []\n",
    "    id_list = []\n",
    "\n",
    "    output = ''\n",
    "\n",
    "    with open(fastafile,'r') as file,  open(os.path.join(jobname, f\"Taxonomydict_CAZy_{family}.txt\"), 'r') as r:\n",
    "        taxonomydict = ast.literal_eval(r.read())\n",
    "\n",
    "        for seq_record in SeqIO.parse(file, \"fasta\"):\n",
    "            if seq_record.seq not in sequence_list:\n",
    "                sequence_list.append(seq_record.seq)\n",
    "                if seq_record.id not in id_list:\n",
    "\n",
    "                    sequenceidentifier = seq_record.id\n",
    "\n",
    "                    id_list.append(sequenceidentifier)\n",
    "\n",
    "                    desc = seq_record.description\n",
    "                    \n",
    "                    #if there's no organism in the description, stop and continue with the next sequence\n",
    "                    if desc.find('[') == -1:\n",
    "                        #remove the sequence from the list again\n",
    "                        sequence_list.remove(seq_record.seq)\n",
    "                        continue\n",
    "                        \n",
    "                    tax = desc[desc.find('[') + 1:desc.rfind(']')]\n",
    "\n",
    "                    #in case of: [[Candida] auris]\n",
    "                    if tax.find('[') != -1 and tax.find(']') != -1:\n",
    "                        tax = tax[tax.find('[') + 1:tax.find(']')] + tax[tax.find(']') + 1:]\n",
    "                        \n",
    "                        \n",
    "                    #if there are still other special characters, just remove them:\n",
    "                    tax = tax.replace(' ', '_')\n",
    "                    tax = re.sub(r'\\W+', '', tax)\n",
    "\n",
    "                    #sometimes the tax is weird (NCBI?) description. Just shorten the tax \n",
    "\n",
    "                    if len(tax) > 100:\n",
    "                        tax = tax[:100]\n",
    "\n",
    "                    #if the last character is a '_' it will be removed from the string\n",
    "                    tax = tax.rstrip('_')\n",
    "\n",
    "                    #ID's like AW_12345 will be converted to AW12345\n",
    "                    if sequenceidentifier.find('_') != -1:\n",
    "                        sequenceidentifier = sequenceidentifier.replace('_', '')\n",
    "\n",
    "                    output += '>' + sequenceidentifier + '_' + tax + '_' + taxonomydict[seq_record.id] + '\\n' + seq_record.seq + '\\n'\n",
    "            \n",
    "    \n",
    "    #write the formatted sequences to the outputfile\n",
    "    with open(outputfile_name, 'w') as f:\n",
    "        f.write(str(output))\n",
    "    \n",
    "    return output\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    formatted_file = format_fasta(fastafile, taxsubsetvalue)\n",
    "\n",
    "    with open(outputfile_name, 'w') as f:\n",
    "        f.write(str(formatted_file))\n",
    "\n",
    "    numberofseq = sizefastafile(outputfile_name)\n",
    "    print(f'Only sequences belonging to {taxsubset} will be included and used for further analysis.' if taxsubset != 'All' else '')\n",
    "    print(f'{numberofseq} unique sequences were obtained after formatting.')\n",
    "\n",
    "    print('Finished!')\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "b48b5982",
   "metadata": {},
   "source": [
    "# Clustering sequences: CD-HIT"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 53,
   "id": "e7a9ac7a",
   "metadata": {},
   "outputs": [],
   "source": [
    "if go == True:\n",
    "    \n",
    "    #clustering cut-off chosen at input options \n",
    "    #name of the input file\n",
    "    inputfastafile = os.path.join(outputfile_name)\n",
    "\n",
    "    #name of the output file\n",
    "    cutoff = \"{0:.0%}\".format(clustercutoff/100)\n",
    "    outputfastafile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_formatted_{cutoff}.fasta\")\n",
    "\n",
    "    #path of cd-hit exe\n",
    "\n",
    "    cdhit = r\"/Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/cd-hit\" #os.getcwd() + '/cd-hit' #r\"/Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/cd-hit\""
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 54,
   "id": "ca2d9c30",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Number of sequences of the inputfile: 136 \n",
      "Number of sequences of the outputfile after clustering at 85%: 68\n",
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "#run CD-HIT\n",
    "\n",
    "from subprocess import Popen, PIPE\n",
    "\n",
    "if go == True:\n",
    "\n",
    "    cdhit_process = Popen([cdhit, \"-i\", inputfastafile, \"-o\", outputfastafile, \"-c\", str(clustercutoff/100), \"-aL\", str(aL_percentage_value/100), \"-aS\", str(aS_percentage_value/100)], stdout=PIPE, stderr=PIPE)\n",
    "    stdout, stderr = cdhit_process.communicate()\n",
    "\n",
    "    print(f\"Number of sequences of the inputfile: {sizefastafile(inputfastafile)} \")\n",
    "    print(f\"Number of sequences of the outputfile after clustering at {clustercutoff}%: {sizefastafile(outputfastafile)}\")\n",
    "    print('Finished!')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "31dcce47",
   "metadata": {},
   "source": [
    "# Include characterized sequences"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 55,
   "id": "2ac399c1",
   "metadata": {},
   "outputs": [],
   "source": [
    "# This script checks if characterized enzymes are retained in the file after clustering and adds the full description of the characterized enzymes\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    #name of the inputfile\n",
    "\n",
    "    inputfile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_formatted_{cutoff}.fasta\")\n",
    "    outputfile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_inclchar.fasta\")\n",
    "\n",
    "    #Following files will be saved locally:\n",
    "    # 1. A TXT file with the characterized GenBANK ID's from the CAZy family\n",
    "    # 2. A FASTA file with the characterized FASTA sequences corresponding to the ID's\n",
    "    # 3. A FASTA file containing the clustered sequences WITH all characterized sequences"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 56,
   "id": "013a817f",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import the necessary modules\n",
    "import pandas as pd\n",
    "from tabulate import tabulate\n",
    "import requests\n",
    "import Bio\n",
    "from Bio import Entrez\n",
    "from Bio import SeqIO\n",
    "from urllib.request import HTTPError\n",
    "from tqdm import tqdm\n",
    "\n",
    "#pandas configuration\n",
    "pd.set_option(\"display.max_rows\", None, \"display.max_columns\", None, 'display.max_colwidth', None)\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    Entrez.email = email"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 57,
   "id": "f67ef65a",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Retrieving data from page http://www.cazy.org/GH173_characterized.html?debut_FUNC=000#pagination_FUNC\n",
      "Too many requests. Let's wait for a little bit.\n",
      "Too many requests. Let's wait for a little bit.\n",
      "Too many requests. Let's wait for a little bit.\n",
      "Too many requests. Let's wait for a little bit.\n",
      "Writing GH173 Characterized GenBank ID file\n",
      "Extracting FASTA sequences from NCBI\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "100%|█████████████████████████████████████████████| 2/2 [00:02<00:00,  1.12s/it]"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Writing GH173_All Characterized FASTA sequences file\n",
      "Finished!\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "\n"
     ]
    }
   ],
   "source": [
    "def fetch_pages(family):\n",
    "    \"\"\"This function fetches the number of pages with characterized enzymes for this CAZy family\"\"\"\n",
    "    #The servers easily get overloaded, resulting in a HTTPError 429. Therefore, keep on trying with 5s waiting time.\n",
    "    \n",
    "    url =  'http://www.cazy.org/'+family+'_characterized.html#pagination_FUNC'\n",
    "    \n",
    "    while True:\n",
    "        try:\n",
    "            df = pd.read_html(url)[1][4]\n",
    "            break\n",
    "        except HTTPError:\n",
    "            print(\"Too many requests. Let's wait for a little bit.\")\n",
    "            time.sleep(5)\n",
    "\n",
    "    if str(df.iloc[0]) != 'nan':\n",
    "        pages = df.iloc[0].count('|') - 1\n",
    "\n",
    "    else:\n",
    "        pages = 1\n",
    "    \n",
    "    return pages\n",
    "    \n",
    "def extract_characterized(url):\n",
    "    \"\"\"Extract GenBank ID's of characterized proteins from CAZy\"\"\"\n",
    "    #The servers easily get overloaded, resulting in a HTTPError 429. Therefore, keep on trying with 5s waiting time.\n",
    "    while True:\n",
    "        try:\n",
    "            df = pd.read_html(url)[1][4]\n",
    "            time.sleep(5)\n",
    "            dfact = pd.read_html(url)[1]\n",
    "            break\n",
    "        except HTTPError:\n",
    "            print(\"Too many requests. Let's wait for a little bit.\")\n",
    "            time.sleep(5)\n",
    "    \n",
    "    #create a dictionary containing the EC numbers of the characterized enzymes        \n",
    "    activitydictionary = {}\n",
    "    for i in range(len(dfact)):\n",
    "        identifier = str(dfact[4].loc[i])\n",
    "        identifier = identifier.split(' ')[0] #if there are multiple ID's for this protein, only take the first one\n",
    "        if identifier.find('.') != -1:\n",
    "            activitydictionary[identifier] = dfact[1].loc[i] #EC number\n",
    "        \n",
    "    #drop duplicate identifiers\n",
    "    df = df.drop_duplicates()\n",
    "    output = df.to_list()\n",
    "    \n",
    "    #create a list containing the identifiers of the characterized enzymes\n",
    "    id_list = ''\n",
    "    \n",
    "    #fetch the taxonomy of every characterized sequence. This is necessary to be able to include only seq by specified tax\n",
    "    txdct = {\"Archaea\": \"A\", \"Bacteria\": \"B\", \"Eukaryota\": \"E\", \"Viruses\": \"V\", \"Unclassified\": \"U\"}\n",
    "    tx = ''\n",
    "    \n",
    "    #create a dictionary of type 'identifier':tax e.g., 'AW1234.1':'E'\n",
    "    chartaxdct = {}\n",
    "    \n",
    "    for element in output:\n",
    "        element = str(element)\n",
    "        pointposition = element.find('.')\n",
    "        \n",
    "        #fetch tax\n",
    "        if element in txdct:\n",
    "            tx = txdct[element]\n",
    "            \n",
    "        elif pointposition != -1:\n",
    "            element = element[:pointposition + 2]\n",
    "            if element not in id_list:\n",
    "                id_list += element + '\\n'\n",
    "                chartaxdct[element] = tx\n",
    "\n",
    "    return id_list, chartaxdct, activitydictionary\n",
    "\n",
    "def CAZy_extract(characterized_ID, characterizedtaxdict):\n",
    "    \"\"\"Convert extracted GenBank ID's to FASTA sequences\"\"\"\n",
    "    \n",
    "    data = characterized_ID\n",
    "    chartaxdct = characterizedtaxdict\n",
    "    total_length = data.count('\\n')\n",
    "\n",
    "\n",
    "    print(f'Extracting FASTA sequences from NCBI')\n",
    "    fastasequences = ''\n",
    "    with open(os.path.join(jobname, f\"Characterized_{family}_GenBankID_file.txt\"), 'r') as file:\n",
    "        for line in tqdm(file, total = total_length):\n",
    "            \n",
    "            #take into account the selected taxonomic subset\n",
    "\n",
    "            if chartaxdct[line.strip()] == taxsubsetvalue if taxsubsetvalue != 'All' else (True):\n",
    "\n",
    "                try:\n",
    "                    handle = Entrez.efetch(\"Protein\", id = line, retmode = \"text\", rettype = \"fasta\")\n",
    "                    try:\n",
    "                        seq_record = SeqIO.read(handle, \"fasta\")\n",
    "                    except:\n",
    "                        print(\"Something went wrong, let's skip this one.\")\n",
    "                        break  # Something went wrong retrieving data\n",
    "\n",
    "                    thisoutput = \">\"+seq_record.id[0:str(seq_record).find('.')+1] + \" \"+ seq_record.description[str(seq_record.description).find('[')+1:str(seq_record.description).find(']')]+'_'+chartaxdct[line.strip()]+\"\\n\"+str(seq_record.seq)+ \"\\n\"\n",
    "                    thisoutput = thisoutput.replace(' ','_')\n",
    "                    fastasequences = fastasequences + thisoutput\n",
    "                    handle.close()\n",
    "                except HTTPError:\n",
    "                    print(\"HTTP Error. Let's try waiting for a little bit.\")\n",
    "                    #time.sleep(1)\n",
    "\n",
    "    return fastasequences\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    characterized_ID = ''\n",
    "    characterizedtaxdict = {}\n",
    "    characterizedECnumbers = {}\n",
    "\n",
    "    #retrieve the number of pages containing characterized enzymes\n",
    "    pages = fetch_pages(family)\n",
    "    for page in range(pages):\n",
    "        url = 'http://www.cazy.org/'+family+'_characterized.html?debut_FUNC='+str(page)+'00#pagination_FUNC'\n",
    "        print(f'Retrieving data from page {url}')\n",
    "        fetchsequences = extract_characterized(url)\n",
    "        characterized_ID += fetchsequences[0]\n",
    "        characterizedtaxdict.update(fetchsequences[1])\n",
    "        characterizedECnumbers.update(fetchsequences[2])\n",
    "        time.sleep(1)\n",
    "\n",
    "    print(f'Writing {family} Characterized GenBank ID file')\n",
    "    with open(os.path.join(jobname, f\"Characterized_{family}_GenBankID_file.txt\"), 'w') as file:\n",
    "        file.write(characterized_ID)\n",
    "\n",
    "    characterized_sequences = CAZy_extract(characterized_ID, characterizedtaxdict)\n",
    "    print(f'Writing {family}_{taxsubset} Characterized FASTA sequences file')\n",
    "    with open(os.path.join(jobname, f\"Characterized_{family}_{taxsubset}_FASTA_sequences.fasta\"), 'w') as file:\n",
    "        file.write(characterized_sequences)\n",
    "\n",
    "        print('Finished!')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 58,
   "id": "fcdca1eb",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CBK67650.1: UniParc ID found\n",
      "Warning: No UniParc entry not found for UMW87594.1. A BLAST step will be performed.\n",
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "#verify that the GenBank IDs of the characterized sequences are included in the uniparccheck list \n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    verified_IDs = []\n",
    "    no_uniparc = []\n",
    "\n",
    "    with open(os.path.join(jobname, f\"Characterized_{family}_{taxsubset}_FASTA_sequences.fasta\"), 'r') as file:\n",
    "        for seq_record in SeqIO.parse(file,'fasta'):\n",
    "            identifier = seq_record.id[:seq_record.id.find('.')+2]\n",
    "            if identifier in uniparccheck[0]:\n",
    "                print(f'{identifier}: UniParc ID found')\n",
    "                verified_IDs.append(identifier)\n",
    "\n",
    "            else:\n",
    "                no_uniparc.append(identifier)\n",
    "                print(f'Warning: No UniParc entry not found for {identifier}. A BLAST step will be performed.')\n",
    "\n",
    "    print('Finished!')            \n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "id": "c990fcde",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "UMW87594.1_uncultured_Bacteroidales_bacterium_B\n",
      "Doing a BLASTP search.\n",
      "Going over BLAST results.\n",
      "Checking UniParc ID's.\n",
      "Sorry, no good match could be found for UMW87594.1. \n"
     ]
    }
   ],
   "source": [
    "from Bio.Blast import NCBIWWW\n",
    "from Bio.Blast import NCBIXML\n",
    "\n",
    "def blast_char_id(infile, no_uniparc, verified_IDs):\n",
    "    #default identity threshold is 95%. Anything lower may result in different domain compositions.\n",
    "    identity_threshold = blastidentitycutoff\n",
    "    E_value_tresh = 1e-20 \n",
    "\n",
    "    #output a dictionary with characterized GenBank ID's that we found an appropriate Uniprot ID for using BLASTP\n",
    "    outputblastdict = {}\n",
    "    outputchar = []\n",
    "    charblastdict = {}\n",
    "\n",
    "    with open (infile, 'r') as file:\n",
    "        #go over each protein sequence in the characterized fasta file\n",
    "        for seq_record in SeqIO.parse(file, \"fasta\"):\n",
    "            ID = seq_record.id\n",
    "            ID = ID[:ID.find('_')]\n",
    "\n",
    "            #if the ID is also present in the list of characterized ID's without corresponding Uniprot ID, blast the sequence\n",
    "            if ID in no_uniparc:\n",
    "            #if ID == 'AAL81357.1':\n",
    "                charidlist = []\n",
    "                identitydict = {}\n",
    "                print(seq_record.id)\n",
    "                print('Doing a BLASTP search.')\n",
    "                result_handle = NCBIWWW.qblast(\"blastp\", \"nr\", seq_record.seq, expect=5.0, word_size=6)\n",
    "                print('Going over BLAST results.')\n",
    "\n",
    "                #go over the blast results\n",
    "                blast_records = NCBIXML.parse(result_handle)\n",
    "                #print(blast_records)\n",
    "                for blast_record in blast_records:\n",
    "                    #print(blast_record)\n",
    "                    #go over the alignments\n",
    "                    query_length = blast_record.query_length\n",
    "                    for alignment in blast_record.alignments:\n",
    "                        for hsp in alignment.hsps:\n",
    "                            proteinsequence = hsp.sbjct\n",
    "                            #identity = hsp.identities / hsp.align_length * 100\n",
    "\n",
    "                            # Calculate identity percentage based on the full query length\n",
    "                            identity = hsp.identities / query_length * 100\n",
    "\n",
    "                            if identity >= identity_threshold:\n",
    "                                #add this id to list\n",
    "                                charidlist.append(alignment.accession)\n",
    "                                #add this id with corresponding identity to dict\n",
    "                                identitydict[alignment.accession] = float(\"{:.2f}\".format(identity))\n",
    "                                outputblastdict[alignment.accession] = proteinsequence\n",
    "\n",
    "\n",
    "                #use the InterPro API to check for UniParc matches. check_uniparc takes a dict as input\n",
    "                #print(outputblastdict)\n",
    "                inuniparc = []\n",
    "                if len(outputblastdict) != 0:\n",
    "                    inuniparc = check_uniparc(outputblastdict, print_output = False)[0]\n",
    "        \n",
    "                #create a new dictionary with matches:identity for matches that have a UniParc ID\n",
    "                newiddict = {}\n",
    "        \n",
    "                #if there is a UniParc identifier for the found BLAST matches:\n",
    "                if len(inuniparc) != 0:\n",
    "                    for ele in inuniparc:\n",
    "                            if ele in identitydict:\n",
    "                                newiddict[ele] = identitydict[ele]\n",
    "\n",
    "                    #use the match with highest identity to the query\n",
    "                    maxid = max(newiddict, key = newiddict.get)\n",
    "\n",
    "                    #add the ID to the verified_IDs list\n",
    "                    verified_IDs.append(ID)\n",
    "                    charblastdict[ID] = maxid\n",
    "                    print(f'For characterized sequence {ID}, {maxid} ({newiddict[maxid]}% identical) will be used for domain-detection. \\n')\n",
    "\n",
    "                else:\n",
    "                    print(f'Sorry, no good match could be found for {ID}. ')\n",
    "\n",
    "\n",
    "    return charblastdict, outputblastdict, verified_IDs\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    infile = os.path.join(jobname, f\"Characterized_{family}_{taxsubset}_FASTA_sequences.fasta\")\n",
    "    blastchar = blast_char_id(infile, no_uniparc, verified_IDs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 61,
   "id": "ce5a67ca",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Creating a file containing clustered sequences and all characterized sequences with corresponding CAZy description\n",
      "Writing GH173_clustering_test/CAZy_GH173_All_85%_inclchar.fasta\n",
      "\n",
      ">ATO84721.1_Actinoplanes_sp_SE50_B\n",
      "MRNRLLPLALTALTLVAAGPPAPAGAARSPAEPVAGTWIGFGYNQDPQYAGGTGTPTPWD\n",
      "PRAFQRMTERTTFIRPPIVRVMLNRDWFNPTGVAGRYEWASVQMTNLYQVLTHYRSLGTR\n",
      "VQLGLWGVQPSSAVNPYTATETATVQADLMRRLYVTDAYTNIVRYTGVNEPNVKNEAKNY\n",
      "SYADWVTATTNLRAAFAAENLPVTLLGGPDTAEATISGQDGDLGLESVTGGAAATGQNAV\n",
      "WRADGLAGFDATFYVSPDTGAADWKFYTSRDGSSWAQLDPASLVQSAPVKTVATNPWYRY\n",
      "EVRNGAPLAAGTDYLRITLPAHAGTERALASLTMTTGAGGTVADPMNDWSHATSHSSGWT\n",
      "HLQGAPTDDWWLEAAGSSLVSGLQTHFYAHELDLADAGYPVQQLQEYPEATLREAVRQVR\n",
      "AAAPGVPVILGETGMKAPKSTDGKDYAFTDEPEHGVRMADLAVQEVRAGVDGAMAWCLDG\n",
      "YAAAVQCGMWDHEGTTEATTALRPWFYTWSLLCRYLPAGSTLYAPAQQPGLRLLQAQAPG\n",
      "SGGWTFVLVNRGTTAVTVPMTAPTGKVTFHRYLYQAAANPPGPVDADGFPVPAGTFLGSF\n",
      "DGGRPVTVPADAVVLITSMS\n",
      ">BBL06275.1_Alistipes_dispar_B\n",
      "MGCGVQWDPYDVHGDGGRLSAADRIRLEKRLDYLSPRIIRVMVSIGSYLTDGRFDPASDM\n",
      "EDLHMILGYCTGRSIPVVFGDWGGGFVDVAAKTVDENRMEQSAKLVRYLLEDCGYTCIRY\n",
      "FNMVNEPNGSWSSTQGDCDLWVRAARAMHASLRRCGLGDRVTLVGPDAAVWTTAETHWVS\n",
      "RTADELGDAVGLYDIHTYPSKAEINAGEYGEMIAAYRAAAPAERRMIVGEIGIKFIDERD\n",
      "AAYAAENERRAARCPYASPADSQMSVFDHMYGTDMADAIMQTAANGYSGCIVWMLDDAMH\n",
      "VNEPGRLKIWGFWNILGEERYGASAERIRPWYYAVALLSRYFPAGSQILESTVRGVPGVR\n",
      "TMWGRSDGKPTLAIVNTSRDRAVELTLEGADSSLAGLDRYLYAEGGLKLDEERLLPVDER\n",
      "IALRSGDRIRIDPGSMVVYTALE\n",
      ">BBL01040.1_Alistipes_onderdonkii_subsp_vulgaris_B\n",
      "MLTLSGRVIDDAYIGNGVQWDPYEVHDVDGRFSAADRKRLTDRLEYMQPRFIRVMGGIRS\n",
      "YLTDGRFDPSRNMEDLHMILGFCNTHGVTVLLGDWGGSLVDRQAQTVDQALIDSSGEMVR\n",
      "YLVEECGYDCIRYYNIVNEPNGSWASTRGDYALWLRAARAMDASLRRHGMAGRVKLVAPD\n",
      "AAVWTTLETHWVSNSVRDLGDAVGLYDIHTYPSKAQVNTGEYSAMISAYRAAAPAGTKMI\n",
      "LGELGLKFIDERDVAYAAENERRIAADPDASPGDSQMFVFDHMYGIDVADAVMQTAACGY\n",
      "SGCVVWMLDDAMHMNEPGKLKIWGFWNILGEERYGAGKERIRPWYYAMSLLCRYFPQGAQ\n",
      "ILASGVSGVGGVRSMFGRTEKGVTLAVVNTDSERTVELTLENPQPGLSDLALYVYAPGRL\n",
      "RLGGERLLPVERGVALAPGSRISLAPETMLVYTSME\n",
      ">UWN65549.1_Alistipes_senegalensis_JC50_B\n",
      "MRQTKTVRTLLLALLALAGCSASLAESNDDERLPESTRTPGYESGASLEVRVGRSTGVTL\n",
      "AGLGVELDPHFLSQNVTRHDGAKASDWDEIVVPRIRKMGIQRFRVMLLPHWWEPLNDNGD\n",
      "PGVAALDRFTFESAEMRSLYKVLDIAQEMNADVTLVLWGCPTYCDLLDPAYAGVKRHFLC\n",
      "SSEGTNWVVEPADSEEFAESFSTVVKHLIERRGYTCIKELTPFNEPDGNIIPLERYVPLA\n",
      "KVLDRRLRADGIRDKVRLNLSDNTDTRHFFLEGCARELSQEADLFNSHTYIFGYDTPNST\n",
      "VLAWEEANVAAAATAGKNHFVGEFGSNQCVGATRQTDIDRYDRGVLMTRLVVNFLNAGAV\n",
      "GTSYWSLIDQYYGRNESYAAMQQLGMWRYMRAAYRQDPDPGVYDRLTDDYQPRPQYYAYS\n",
      "LLTRFIRKGSEVYPLDLGNEFAAGTAVRAAAGRWTYVIANATDETLSFDLKNTLRGGMSA\n",
      "CKVYVYEERRLPDGDELIAPSLQLENSGGTFCVGVKARSVIVLTQL\n",
      ">CBK63196.1_Alistipes_shahii_WAL_8301_B\n",
      "MKNFGNLLLACMAALLGACAGESAGKCDAVVRIDADSVVNRGYIGNGVQWDPYALDYGQG\n",
      "RVEISDADWAKLYARLDFMRPAFIRVMTNTTSVVRNGRLDRMRGFEHLSHILGYCQSHGV\n",
      "TVMFGDWGGSLMDARAGTVNRTLLDHAAAYVAWLVGEKGYDCIRYYNLVNEPNGFWSAAD\n",
      "GDFDLWAKAVSYFRGRLDAEGLAGKVELVGPDAAIWGPEEAWWVSRSRDELGDRIGLYDI\n",
      "HTYPSKCTVNSGEYTRILEAYRREVPAGKKIVMGEIGFKFVEPADSLLQAENLRRAAAHP\n",
      "NASTDDSQMFVYDPMYGTDMADALFQTIHAGYSGCIAWMLDDAMHFKEAPDKLKIWGFWN\n",
      "IFGDEIFGAGEERVRPWYYAWSLLCRTLRPGSDFFAANVRGAAGVKAVAAVKDGRRTVAV\n",
      "VNVSREPRRVRIECPGWERFRQATRYRYGEGLMRTEGDHTLLPDATGLRIDFRSGAEYDM\n",
      "PGESMILLTEQND\n",
      ">UZO80939.1_Aquimarina_sp_ERC38_B\n",
      "MLKNINYKYVLLLAFLVTGISCSDDFEAPAEEPISTELVIELGTVINDSYIGNGVQWDPY\n",
      "PQAYKFWDLPIQDVDWQKMYDRLDYMKPSFLRVVFGSYDKYAHLGADNYNPIIFLEGMER\n",
      "ILQYCQDNNITVMLGDWGYNQMDVNQNRIFENRITNAAKYVKFLVEEKGFTCIKYYTTVN\n",
      "EPNLEGSATEGDYDLWKRTTEAFYRKLDSLGVSSKVKLAGPDIAPFSDNLTNWVTDMTAD\n",
      "LGDKVKLYDIHTYPPKEAMYNGVYERTLAAYKNAAPAGTPIVIGEYGFKYETGTSQIDQN\n",
      "LYNANLENINSSANIALDSNTLVDEYFHGVDLIAATMKIVNAGYSGAINWNLDDAMHSGS\n",
      "NSGQDLKVWGFWNILGVEILGNPQKEEVRPHFYSFSLISRYMQNGTKVFKVNIPRLVGVD\n",
      "AIAVENDGKYMIAINNIFSEDYEINVKAIGLSLSGAKKFVYKENDRTVDVNGYPTPEEEN\n",
      "LSYDFSAGETLSVPGTTLTVITNFDY\n",
      ">UZO80937.1_Aquimarina_sp_ERC38_B\n",
      "MMRSTLLFLVFVVLLLTVNCNEKVGESAFAKAGISLSFLKENTINTQFLGHGVQWSAYPH\n",
      "ADSEDAEWGFLMTDEKWEELYRRLDFVNPHVIRVMDGAGWRYYQGNDKDGNPIVDYNTQE\n",
      "VKSLYKLLDYCQKNDIKVMFGEWGAPQSGSKVKNPIDRADDDRWIEMITGYLNHLVIEKG\n",
      "YTCITYYNLVNEPNGYWASTDGDWDQWSAGYTKMAKALANSPLSKYVGMVGPDATVQWNH\n",
      "PTHPKPSADWMYSTIEEHNEITKAYEVHIYANQDEIRSGNLIKFLQPFADSLKNIDKPFL\n",
      "LGEIGMKYNGELGEENKKRAAADPYASTEDSEMFVYDHFYGVDMADAAAQSMLVGMGSAI\n",
      "AWNVDDAMHTKGDAGEKSKLKKWGMWNILGEHFNGPDELTPRPWSYPWTVLCNIFPPGSK\n",
      "VMKPIINVKNDSIRAVGAYKNDMFSMMLVNQSKTGQTYNVATDTYTNGVPLYLYNYVDGE\n",
      "NIKNSSGFPVPAREVTYKKDLGVQVELPANSVVFISTIKLK\n",
      ">AGY53053.1_Bacteroidales_bacterium_CF_B\n",
      "MMKNLLLSLLLITGLASCTTNATIITISPKVSNPDIIGNGAEWDPYCEAVQWGSPLTDQM\n",
      "WATIFERTDKMGMSIVRCMINSPFRYYDKKTGSFKKEQNSESLLKVLEYCQKNNIAVMYG\n",
      "EFNPPAPELKKDPKWIKMSIEYLNYLVADCGFTCIRFFIPTNEPDGNWSMYDGDYQMYRD\n",
      "IVEMFNKEIKSYPALASHIRFAAPDVVLGYKNPKYDMDNSAWISRTSEIDSLVGVYEIHA\n",
      "YPGYKQVRSGEFARMFREVAQSVPKGKKIILGEAGYKPGREEDSLENKSHFERLQATPLI\n",
      "ENKEGADCNMRVYDFEYGLDMALLAMEVMNNGGAGVAVWMLDDSHSVGDTGEAKNLKIWG\n",
      "MWNIFGEKVWKMKDEEKIRPWYYAWSLMCKYFPAGSDILTPGEILDKDIKVVAAVKDDKL\n",
      "TIALLNLSTEKKVLHINLPKTIQNASMYTYKKDTGVNDYSLDPARSGLTAEKVLKTDIAA\n",
      "CSLLVVTEL\n",
      ">ANU59401.1_Bacteroides_caecimuris_B\n",
      "MAMKMTHISKTLLSIVCTLWGMSACSDDYNKYDDCPACNYYPVAVGNSTGTPVHAIGVEM\n",
      "DPHFFSQNITRNDGSKAEDWENIVVQRVKKMKVQQFRIMMQPQWWEPSNDNNDPNVADMS\n",
      "KFTFDSEEMQSVYKVLDMAQENNIGVTLVVWGAITNIDLLSGINNGQKHFLCDARSYNVN\n",
      "PGWIAGIDNYEEFAENFSTMVKYLIEEKHYTCINQITPFNEPDSHIAGYGRIMWQGDFET\n",
      "MGWQDTYAPMVKALDAKFKADGIRSKVHFNLSDNTDGTPGYIAACVSAFTNDEADLYNSH\n",
      "VYKFDYNTPNSTLVNWERQNIASAGGKRHFVGEFGFPGYGSARQYGIDTYTRGVQLIRVA\n",
      "LNYLNAGACGVSYWSLIDQYYNRNASYSEMQQLGLWKYLKSAYTEDPDVYSKIKEDYEVR\n",
      "PQYYAYSLLTRFVRQGDEVYPLDLGDELIAGSAFLNTEGKWTYVLSNATDKDKMIQLEND\n",
      "KEGANGEYNVYKYMEGRLPEGDNLIESTETVNTQENNLKLKLSRSSIRVLVQK\n",
      ">ANU59398.1_Bacteroides_caecimuris_B\n",
      "MKKRILYYLFILLLFPHNGTGQTVARMSDRPVNTSQWITTHFARGVVPPFSFEYEGKPSQ\n",
      "EFIKNWSYTATRQKSDDPKVLKYLYTYREPSGGLKVECEVKGFTDFNTVEWVLRFTNQGK\n",
      "KNTPEIANVKVSDITFRYQHPGVFNLHHSEGSHASKSDFSQQLTILSPGDNLYMRPEGGR\n",
      "SSQMRMPFFNIESPANQGVIVAIGWTGTWFADVRCADQQSVALTSGIERLKTYLYPEESI\n",
      "RTSSVCLSFWNGSDRMKGHNQFRRFVQAHHTWKVGGKPTVYPISTSFNYGDPTPCNEYTC\n",
      "LTTDYAIAMVKRYEQFKLVPEVFWLDAGWYNHSADVANHKNWANTVGNWTVDSIRFPEGL\n",
      "RPIADEVHRVGSKFMVWFEPERVMKGSAWALQHPQWMLDARGKAKQEDWTRDGEHDSYLF\n",
      "NLGNPEACRWMSKYIGDFLEENGIDYYRQDFNIEPEGFWAANDEPGRQGICEIRYIEGLY\n",
      "SFWEYLLNRFPGLLVDNCASGGRRIDLESISRSAPMWRTDYSYGEPIGYQCHTYGLNLYL\n",
      "PLHGTGTVSADKFTFRSSLGTSIIYNWKITEAGQSIYDMRDRQAEFKELRPYFYEDYYPL\n",
      "SGINNITSENIWLAYQLYRPSDDSGYIVAFRRKDNPDKSYTVNLSGLHPDHTYILTNKDT\n",
      "GEAIKKTGKELANGFTLTLDNPQSSLIIKYQSSTTAIQKLSVGKKTGVKLRAIGAELDPH\n",
      "FLSQNVTRNDGAKAEDWERIVVKRVKEMGLQSLRVMVMPQWYEPKNDNPDASKIDWHNFT\n",
      "FNSVEMQSLYKVLDMAQEQKMEVTLVLWGAPPGHFLAEGNYGNWVVAPTNYEEWSENFSA\n",
      "LVQHLLNNKKYTCVKEITPINEPDWSYIIKGKAAPTADYIEMCKVLDRRFKEDGIRNKVH\n",
      "FSLSDNSDGGTGTHKYLAACTKGLANVADVFNSHTYIFGYETPNSTILDWEKQNSQLASS\n",
      "VGKAHFIGEFGGNQCVGATRQKDIDLYERGVLMTRIAINLLNAGASGVSYWSLIDQYYGK\n",
      "DADYGAMQQLGLWKYVKKTYASEPYYNDIKSDYEVRPQYYAYSLLTRFIRPGAEIYPIAT\n",
      "PEEWYAGTAVRNTNGKWVYVFASGMDQEKAISLINQHTQTKGNYQVYRYIKDGLPTTDQM\n",
      "LAPDAQPLKVNDKILCLLPAHSVIVLKQE\n",
      ">UBD71149.1_Bacteroides_cellulosilyticus_B\n",
      "MKRFAILSVFFLWGGYAASQTVVSVDTKQIINEGYIGNGAQWDPYQLDYGKGRLDISEAD\n",
      "WKKMYDRLDFMRPQFIRVMTNTTSVMQDGVLYPERGLEHLSHILDYCQSRDVTVMFGDWG\n",
      "GGMVDARKEMIREKNLSAAAEYVRFLIEEKGYSCIKYYNLVNEPNGYWSSTDGKYSLWAR\n",
      "AIRFFYGELQKNKLAGKLSVVGPDAAIWTADEAWWVDSCATHLKDEIGLYDIHTYPSKIT\n",
      "VNSGEYTDIIRAYKQAVPAGRKIVMGEIGFKFVEPADSVYQRENLRRAAAKPYASMDDSQ\n",
      "MFVYDFMYGTDMADALFQTVNAGYSGSVVWMLDDAMHAKEAPDKLKVWGFWNIFGEEYFG\n",
      "TEEEEVRPWFYAWSLLTRYMPAGSRAYKVEVEGDKSLKAIAVEKDGKYMIAVVNVSREEK\n",
      "SVLLKSTSLPVLKGVKQYLYAEGRLQKEGDCRLLPHRQGMTLRPAEGEAFQMPGESLVVY\n",
      "TNFDY\n",
      ">QUT88730.1_Bacteroides_cellulosilyticus_B\n",
      "MKINMILSCMLLWLVSACTSQEVVEITVSPEVTNAGYIGNGAEWDPYDEAEAWGASISDK\n",
      "DWETLCKRLDFMKPQYIRCMINSPYRYYDSETGTYDKTRNIASISRLLRYCTERGITVMY\n",
      "GEYNPPTWDMKQDQKWVDMSVDYLNYLVNDLGFSCIKYFVIFNEPDGNWASTNGDYEMWK\n",
      "QMLFRFHRKMKEYPGLTEKVMLAGPDVVADYKNEASAYDAEGWVKQTALDADSIIGLYDV\n",
      "HAYPGQNEVRTGQYPEILSRYKRHVPEGKKIVLGEAGYKYWRDADSLLMAEYNRRVEGHP\n",
      "FTKGSDCNMLCYDYFYGLDMPLLAMEVMNGGYSGMAVWMLDDAMHSSGDSGKTEDVKIWG\n",
      "MWNILGEEVFNKPDEEQIRPWFYTWSLMCRYFPAGTDILHTAVASEDKDVYVVAGTYQGK\n",
      "LTVAMVNVGEKDKSVQLTLPRPMENASLYKYEENLQPKDADGFPVPQETGFHLKGTYKTT\n",
      "LKAQTFQLLTDIQ\n",
      ">UWN88717.1_Bacteroides_eggerthii_B\n",
      "MKRNIFLSCAALLAASVFASCYKDDHQPPMVEGGHAGVDFVIDNNKVITDNFLGFGTQYN\n",
      "NNLYTTRTFENDGVSEENLPDLEKKVLALGSQYVRIFFDKKNWESVSGYNPEYKASFIRT\n",
      "VELAQKTGALVNITYWHSSIPEDMGRFADEIYDLIVNKGLTCVKQVTIQNEVNSTKITPD\n",
      "EYRVLYSVFIDRLKELGIRDKIQLVGGDLVQDNQKTWFEYMSTSMATLLDGYSSHIYWDY\n",
      "WDKVKPVDRLSGVADLLSNMQGQGIKPCYITEYGVRGEKSGGAFNNPGYLRGTDTPIGRT\n",
      "NECALRHVTFHINALNYGFAGLVKWDCYKAKYDNGNQYFPVIGSGTDGYPLYPSYWMTWA\n",
      "FTHSCQPGWKVLSATSVVSSAHKLCAAMSDGVSNYTIYAQTTATVQTPFVISGIPANKKF\n",
      "RVLAWNDDLMGGLTELEPVTSDAEGVVRFNVKPDGFITLTTIDFTLPEGLE\n",
      ">UVR10658.1_Bacteroides_ovatus_B\n",
      "MSDITFRYQHPGAFNLHHSEGSHASKSDFSQQLTILSPGDNLYMRPEGGRSSQMRMPFFN\n",
      "IESPANQGVIVAIGWTGTWFADVRCADQQSVALTSGIERLKTYLYPEESIRTSSVCLSFW\n",
      "NGSDRMKGHNQFRRFVQAHHTWKVGGKPTVYPISTSFNYGDPTPCNEYTCLTTDYAIAMV\n",
      "KRYEQFKLVPEVFWLDAGWYNHSADVANHKNWANTVGNWTVDSIRFPEGLRPIADEVHRV\n",
      "GSKFMVWFEPERVMKGSAWALQHPQWMLDARGKAKQEDWTRDGEHDSYLFNLGNPEACRW\n",
      "MSKYIGDFLEENGIDYYRQDFNIEPEGFWAANDEPGRQGICEIRYIEGLYSFWEYLLNRF\n",
      "PGLLVDNCASGGRRIDLESISRSAPMWRTDYSYGEPIGYQCHTYGLNLYLPLHGTGTVSA\n",
      "DKFTFRSSLGTSIIYNWKITEAGQSIYDMRDRQAEFKELRPYFYEDYYPLSGINNITSEN\n",
      "IWLAYQLYRPSDDSGYIVAFRRKDNPDKSYTVNLSGLHPDHTYILTNKDTGEAIKKTGKE\n",
      "LANGFTLTLDNPQSSLIIKYQSSTTAIQKLSVGKKTGVKLRAIGAELDPHFLSQNVTRND\n",
      "GAKAEDWERIVVKRVKEMGLQSLRVMVMPQWYEPKNDNPDASKIDWHNFTFNSVEMQSLY\n",
      "KVLDMAQEQKMEVTLVLLGAPPGHFLAEGNYGNWVVAPTNYEEWSENFSALVQHLLNNKK\n",
      "YTCVKEITPINEPDWSYIIKGKAAPTANYIEMCKVLDRRFKEDGIRNKVHFSLSDNSDGG\n",
      "TGTHKYLAACTKGLANVADVFNSHTYIFGYETPNSTILDWEKQNSQLAASVGKAHFIGEF\n",
      "GGNQCVGATRQKDIDLYERGVLMTRIAINLLNAGASGVSYWSLIDQYYGKDADYGAMQQL\n",
      "GLWKYVKKTYASEPYYNDIKSDYEVRPQYYAYSLLTRFIRPGAEIYPIATPEEWYAGTAV\n",
      "RNTNGKWVYVFANGMDQEKAISLINQHTQTKGNYQVYRYIKDGLPTTDQMLAPDAQPLKV\n",
      "NDKILCLLPAHSVIVLKQE\n",
      ">UVO70767.1_Bacteroides_ovatus_B\n",
      "MTLVVWGAITNIDLLSGINNGQKHFLCDARSYNVNPGWIAGIDNYEEFAENFSTMVKYLI\n",
      "EEKHYTCINQITPFNEPDSHIAGYGRIMWQGDFETMGWQDTYAPMVKALDAKFKADGIRS\n",
      "KVHFNLSDNTDGTPGYIAACVSAFTNDEADLYNSHVYKFDYNTPNSTLVNWERQNIASAG\n",
      "GKRHFVGEFGFPGYGSARQYGIDTYTRGVQLIRVALNYLNAGACGVSYWSLIDQYYNRNA\n",
      "SYSEMQQLGLWKYLKSAYTEDPDVYSKIKEDYEVRPQYYAYSLLTRFVRRGDEVYPLDLG\n",
      "DELIAGSAFLNTEGKWTYVLSNATDKDKMIQLENDKEGANGEYNVYKYMEGRLPEGDNLI\n",
      "ESTETVNTQENNLKLKLSRSSIRVLVQK\n",
      ">UVO70768.1_Bacteroides_ovatus_B\n",
      "MKMTHISKTLLSIVCTLWGMSACSDDYNKYDDCPACNYYPVAVGNSTGTPVHAIGVEMDP\n",
      "HFFSQNITRNDGSKAEDWENIVVQRVKKMKVQQFRIMMQPQWWEPSNDNNDPNVADMSKF\n",
      "TFDSEEMQSVYKVLDLATRRIISE\n",
      ">QGT72561.1_Bacteroides_ovatus_B\n",
      "MKKYFFIFIVAFFASCSPVEQDVIITIDTETVLNDCYIGNGAQWDPYQLDYGKGKLTISE\n",
      "ADWEKLYDRLDFMRPQFIRIMINTSSFVDQGRLVPERGMEVLSKMLDYCQSRNVTVMFGD\n",
      "WGWSVIRAREAEIDSQSLRHAAALVDYLVHNKGYSCIRYYNLVNEPNGYWAATNKSFPLW\n",
      "ASSVRQFYQYMKEFDLIGEVGIVGPDIAIWDKAETGWMDSCAVQLNEQIELYDIHTYPSK\n",
      "VTVNSGEYADIIAAYKEKIPERKKIVMGEIGFKFVEKADSLYQKENIRRARSKVNASLED\n",
      "SQMFVYDYMYGTDMADALIQTVNTGFSGSIAWMLDDAMHSNEAPDKLKIWGFWNIFGEEC\n",
      "FGAEEENVRPWYYAWSLLTRYMPAGTAVYRTDTTGEPFVKAAVSGKDGKYMIALVNVSDS\n",
      "PKTVKLKSDVLSSLSGCKKFIYSDGTLKQKGDCLLLPNDENLILHLEKGETVTMPAESLI\n",
      "VYTNYDY\n",
      ">UWO00929.1_Bacteroides_sp_D2_B\n",
      "MKVLLQILFLLFCIGCQKPVQNAEVIFRINKDSIISTSYLGNGVQWDPYQLDYGNGRVTI\n",
      "SESDWNKLYARLDHMRPQFIRMMVYTTDYLKNGKLDEMYDFDQVSKILTYCQERGITVMM\n",
      "GDWGGRMVDPVTNRIDTFMLSNAARYADFLVNRKGYDCIKYYNMINEPNGDWSSNQANYD\n",
      "LWARAIRYFDRRMHDYGLADKVGLAGPDAAIWDQSEAWWIDSCATRFNEAIKLYDIHTYP\n",
      "PKSTVNSGEYSKIIRAYKERVPQGSQIIMGEIGLKFLKTDTLLEKENNERISKVPHASRE\n",
      "DSQMFVYDHFYGIDMADALFQTMNEGFSGALIWMLDDAMHSKTEEGPDKLKIWGFWNILG\n",
      "EEYFGGAKEEEVRPSYYAWSLLSKYIPKGSTVYAVETGEDKGVRAVAVEHKGKYTIGVVN\n",
      "VSGQERTVLFKSNSLPVLEDIRQYNYIENEILKEGDCKQLPNVTGIKLNLEKGLFLELPT\n",
      "DGLVVYTNME\n",
      ">UWO00930.1_Bacteroides_sp_D2_B\n",
      "MKNIIKGLICLALFLSGCGKDNGGDTPPVPEPDVNTLLVTPKVLTNSYLGNGPQWGGYDI\n",
      "VNAWTGNATLSEQDWNTLFKRVSFMRPSLIRIMVSQGWNYMNGEVYSPEKSDPVLGKILS\n",
      "YCQEKGITVQLGEWGHVGGSGIDATWVDHATDFLSYLVKEKGFTCIKYYTIVNEPNGDWS\n",
      "STVGSYPLWKNIIQQFYRKMNEKQLTDKVRIMGPDVAIWSIAETSWVVNTRNELAEEVKA\n",
      "FDIHAYPNNDDVHTTSFLQLLKAYKAASNLDAPIIMGELGFKYSATSSLGKANASRIKAD\n",
      "PFAADDSQMHVYDAFYGIDMADATIQVMLAGFGGVTYWDLDDAMYNDDGSSSSTKLKRWG\n",
      "FWNILGSEKFHNPDDEKIRPWFYTTSLLCRYFPSGSTIYDVTLPKPVKSGLRAIAGMRNG\n",
      "KVTIAIVDSSTNDYLFNLGMENGALLQGIKTYKYQSQQGAHFIGTVDADGFASPVDAGET\n",
      "IDLSGGKLREINLPAQSFMLLTNME\n",
      ">UVR93289.1_Bacteroides_thetaiotaomicron_B\n",
      "MTIDMKLIFVQLVIVCFLFACKSENTVEITVLKDTVSHNYLGNGVEWDPYDEAESWGHSV\n",
      "SEDDWNKLFKRLDFMKPQYVRCMINSPYRYFISKDGSFDKTRNINSISRLLRYCTDRNIT\n",
      "VIFGEYNPPTFDMKDSEKWVDMSVAYLKYLVCDLGFTCIKYFNIFNEPDGDWASTNGDYL\n",
      "LWKKMLFLFHKKISEYPMLAKQVKLAAPDVVMDYHNSNSEYDAEGWLMQTIADADDIIGV\n",
      "YDLHAYPGQAEVRSGSYSKLLASYKNHIPSDKQIILGEAGYKYWRTADSLLMAEYNRRLV\n",
      "NHPYTKGTDCNMLCYDYFYGLDMPLLAMEVMNAGYSGLAMWMLDDAMHSNGDSGKPEDIK\n",
      "IWGMWNILGEEVFNSPKEEELRPSFYTWSLMCRYFPSGADILKTEVLDGNNEIYAVAGMY\n",
      "KGKLTVAIVNIGKEDKKINLSLPKEMTSALLYVYEEEHLNKDENGFPLPVQTGMKLNSYS\n",
      "NTIKSNSFIILTDLSDE\n",
      ">QZU84679.1_Bacteroides_thetaiotaomicron_B\n",
      "MNKVIPLLAILLWFCTACGEKKSTLVISDQPVSANFMGNGVEWSAYPHGDSPEAEWGYLM\n",
      "TDEKLQKVCSRLDYMKPRIVRLMDVAGWRYFKGVDTKGNPIVDFECAEVKMVCKLLDYCQ\n",
      "KNGITVLIGDYGVPGFWGYKGKVDRVDDPRYVDMTIRYLSYLIKERGYDCIKYYIITNEP\n",
      "NGTWACTNGDWEQWKRGVSMFAEGFKAAGLPLEMSAPDVVEMSDNPASEYTGRQWVEQTM\n",
      "IQLDSIVGNYNIHCYADAYFVRDGRFQKHHKEVADILKTTGKPVIFGEIGVLYKTGELGE\n",
      "EYKKLLPQKPFASEDSQLHVYDYVYGIDAADALIQSMKAGFQGASAWMLDDAMHTIGDLG\n",
      "DKNQLKVWGFWNSLGTELLNDEKEEEIRPWFFTWSLMCRYFLPGMEIFNPENEELFPNLR\n",
      "VVAGRKGEEATIALLNAGDSTYTFCLKMNVGSSKQDFAVYSYTQTGYKTDENSFPVAESV\n",
      "ARAKDLLSGEEEIKILPRSFKLYTNIKID\n",
      ">CBK67267.1_Bacteroides_xylanisolvens_XB1A_B\n",
      "MMNLKTIIGTFVVGMLLVSCTHSDNRLTVNVFQEVVTSGYIGNGVEWDPYDEAESWGASV\n",
      "SDEDWQKLFKRLDFMRMGYVRCMINSPFRYYDPQTGKYDKTRNIASLSRLLQYCTDHNIV\n",
      "VMYGEYNPPTWAMKDEQCWVDMSVDYLNYLVNDLGFSCIKYFVIFNEPDGNWASTDGDYD\n",
      "LWKSMLLRFADKMKEYPGLDGKVKFAGPDAVVDYKNPSSPFDAAGWVKQAATDLDSHIGI\n",
      "YDIHAYPGQHEVRSGQYAEILARHKEFIPAGKKIVLGEAGYKYWREADSLLMKEYNRRVE\n",
      "GHPFTKGTDSNMLVYDYFYGLDMPLLCMEVMNGGYSGIAAWMLDDAMHSSGDSGKTEDIK\n",
      "LWGMWNILGEEVFDDPSQEEIRPWYYTWSLMCRYFPTGSNILKTTLDRTKGVYAAAGEYQ\n",
      "GKYVFAAVNIGDEDRSLDISLPAALENVSLYVYEEGNRQTNNEGHPVPVQTGLTVDGTYQ\n",
      "TILKAQSFILLTNID\n",
      ">QEG33916.1_Bythopirellula_goksoeyrii_B\n",
      "MRSNYLSSELGTPRQLPIIEVRVDLSRAVSRDFLGVGVQCDAYPWWDINELEWDRIFKRL\n",
      "SYMRSPLFRTMQSAFYYWHDIDGSGKPTYRFDSSYVNKLVKLLDWCEANGTQVILGEWGA\n",
      "PTSVTGISLANDDPLWTRIVVEFLMELFRRRSYQCVRYFNLINEPHGSWSSTAGCFDEWR\n",
      "SAILNLHQDLQRSGLHDRVAIAAPDANSEWLRKTLTDSELREVTAIYDEHWYVTRDEINA\n",
      "GAVEQRCREQCRCISQCDPGKPYILGELGIVDGKTEDDRQPNVFGFSYGVEMADAAVQLM\n",
      "RGGSHGFIAWYLDDAMHFFGDGEIVRSDDEPLPKDAYERRKVWGMWNSLGNQMGDPSDAQ\n",
      "LRPWFFTWSLLSRYFPAGCEIVNVELDQDAPVIIAAARISQEGTNHISLAIVNREDAPRT\n",
      "VRVHIPEMQVLTTLARFDYFDLDSDDRPDSWPTSIDNQGCDVFPSPSLFLSEVDFQSGLK\n",
      "IALDGRGVVILTSLETAETMPPLYRSP\n",
      ">ABP68096.1_Caldicellulosiruptor_saccharolyticus_DSM_8903_B\n",
      "MKRWMKFFKSLSGGILILTLVFVGTFFAIDFSKVKAADGTAVINFNKVYWGDFLGVGIQW\n",
      "DPQDGSLPEIDSTMWDKVIQRVDFMNAKFARVMINVEDYFNGSTYNWNSVVMQRLYKILD\n",
      "YCQSRGVTVMLGNWWKPSWASSFTDSRFLTAICDLLNYLRNSKGYTCIRYYNFLNEPNGE\n",
      "WMYGENPPDLETRWNNWKDGIIALHNMLSSRGYTNWVQLVGPDTAYQDDWVDRALNNLGS\n",
      "QMGAYEFHIYKDYDSQVYNGEIEATVGAKRNLINSSTQSNKHLWLGELGMKEGKDPIYDC\n",
      "QPRVTTFEYAVVMSDGIAQVIRAGGSGVIPWCLDDAMHLASSDGTLKKWGMWNSLGGKTV\n",
      "GTKTYPISDQNLRPWFYPVSLFSKFFVQGSQVVEVSGPSIPGVRVAAVKKQNGTNWDVSI\n",
      "VVVNNNDSAKSILITAPGVTNTAIFKQYNFFASDQPKDNDGFPLPKMDRVNNLSNGILVD\n",
      "LPSRGVVFLTTLNGGTPVSVSSNLALNKPAYASSTENSNYPPNYAFDGNLNTRWSSAWSD\n",
      "PQWIYVDLGSVQTISRVKLVWEAAYAKQFQIQVSTDNVNWTTVYSNYNGTGGTNDITFTP\n",
      "VNARYVKMYAWQRATQYGYSLWEFEVYQ\n",
      ">BDI31947.1_Capsulimonas_corticalis_B\n",
      "MKKSLVSPPSIAALAWTLALAAGPIWAASASDVTVRLGKTVTSPFMGLGVQWDRFYYTPT\n",
      "PAAWNMIVRRMDYCRPGYLRVMVGTGDYCVGFDAQGKPKYIWTEGTAAQKADFKNLTDIL\n",
      "DYAQSRGVPVILGEWSPPKKELMAEETDPRWPQVMADFVSYLRDKRGYSTITFFNCINEP\n",
      "NGDWSGNKDYATWLSVVRSLRREFDARGLNASVRIIGPDTTGNTQWLEPFTWIDRATKDA\n",
      "PDTFGAWDLHWYALDSEVLDGSMEKLLAEKREVIAKNDPDGLSKPRFLGESGLITGRVNG\n",
      "DQQPRVRAYEYGVMMADYVAQVARAGWQGALAWDMDDAMHLVSWDRRPDPPDALTMKLWG\n",
      "FWNSQGSRMTPPEDESPRPWFYTWSLMSRLFPRGSRIVETTSPAIARFRAVAATIQRSGR\n",
      "TDVSVMLVNNDAISRTMTVKVPDLKQSPTLTCYRYFETDRPEDDRRFPKAASLLKKVDLR\n",
      "KGCTVMLPSRGVVFLTTMIDRQKNQSP\n",
      ">ADV49313.1_Cellulophaga_algicola_DSM_14237_B\n",
      "MLKKQLFNYIILLIFLPLASCQTVKKTELVKIEADKIISSEFIGNGIEWSAYPHADADDA\n",
      "EWGLLMTDKKWETVFKRLDYMKPKIVRVLDQANWRYLEGIDKDGSPILNFENQEMHALYK\n",
      "LLDYCEKNNIKVILGEWGQPYKVHDTHLKMQNTFTGATDPKWLNSIAQHVDYLVNTKGYT\n",
      "CIKYYNLVNEPNGYWSSIDGNWNEWKLGVKKLDSAFVSKKLKTPVHVIGPDATPFNNEKS\n",
      "KYTGAEWAKESVLQLNDVLAAYDVHDYPTKEFVRSGDFEKHYTAMISFADSVARKPFILG\n",
      "EIGFEKYVESNIKRYEADPFASPDSQLSIYDYDYGVDMADVLVQSMNSGFDAVIAWGLDD\n",
      "AMHTNGDTGEKNQLKKWGMWNILGKELTGDVKEEDIRPWFYTWSILTRYFTNDMKIVKTT\n",
      "GLDINKVRMVAGWSASNDVTFSVVNNSDKEATFYLETENLKNKSFKKYSYSENNRPVDSN\n",
      "NFPKAVQNNLSFTSGTEQITIPAKSVLLYTTYNY\n",
      ">ADV49311.1_Cellulophaga_algicola_DSM_14237_B\n",
      "MTVKNIFAAVLPMLLIAASCDDEEPAFTSLEKNREVVITEELVSTDFVGNGAQWGGYEMT\n",
      "PTWLGTETLSDADWNTLFNRIDFMRPPFLRIVTNPAWSYDNNGTYDETTKTVSLFKMLDY\n",
      "AKDRNIEITFGEWGHSSTDDISTIDMGWIQNSVKFLNHLVNEKGYTNIKTINIINEPNGD\n",
      "WSSTKGDYNIWKNVQLAYLEEIKKYSLADLKVMGPDIAVFNTASQTDWFTKTEADLGDNV\n",
      "GLYDIHVYPQQQLIRSGEFAQMLRAYKKETPADKRIVLGEIGFKYTEVDAQLKQENEEAI\n",
      "ANDPYAGEDSNMMIYKAFYGIDMADALIQAMREGYSGSLVWNMDDAMYNSPDNGDYQSDK\n",
      "LKRWGFWNILGEEHTGNAADEAIRPYFYPVSLLTRFFPAGSDIYKVNLPNKKGLRAVVGT\n",
      "YNGKQTIAIVNSHYTTYELELKSDFLGAITANKYSYKSKADGSFTGTVDADGFAVPSENN\n",
      "MNLNFAEGVKMTLEGESFILFTNME\n",
      ">APU67655.1_Christiangramia_flava_JLT2011_B\n",
      "MPDRLKAIFFVGTFLLLFGCDQKKDSETFDSLTLHPERIISPSDDFIGGGVEWSAYPHAD\n",
      "SDKAEWGLLMTDQKWQEVFKRLDFMQPKIVRVLDQANWRYLEGINDNGNPIVNFDNQEMQ\n",
      "ALYKLLDYCEKNKIKVILGEWGQPYKVHDPELQLQNAFSGASDSKWISIIVEHIDHLVNK\n",
      "KGYTCIRYFNLVNEPNGYWSSVDGNWKEWKSAVTKLDSAFKKNGINQVDVMGPDSTPYNN\n",
      "EKSDYQGMEWPKQAVLQLNDVLGAYDVHDYPTVEKVRSGKFQEEYTKLISFADSVAHKQF\n",
      "VLGEVGFEKYVEPNITRYEEDPHASPDSQMRVYDYDYGVDMADVMAQSLNAGFDGVIAWG\n",
      "LDDAMHTNGDSGDTTQLKRWGMWNILGEELTGDKSDEAIRPWFYTWSLMTKYFKGDLNIL\n",
      "HVQGSLPEGVRAVAGKSTKGDCTLTLVNNSGQPVSLSIDGKSFSMNDQRFQKYLYSEKER\n",
      "PVDSEGFPVALKRNIRMPEALTIPAKSVMLFTTYTN\n",
      ">APU67659.1_Christiangramia_flava_JLT2011_B\n",
      "MQREHNSLPGLIILTFLILAFYGNSCIAQTRATVSINGNSLMPNKYLGNGVQWDPYQLDY\n",
      "GAVTLEIDDQDWKKLYDRLDFMRPQVIRVMINTTSSLNNGKLDPQKNLSNLKPILDYCQS\n",
      "RKVSVTFGDWGGGMVDSSANLINKENLEFAAEYLDFLVNEQGYSCIKYYNLINEPNGFWS\n",
      "AADGNYELWRDAAVYFQQSLERLKLVNKVQIMAPDIAIWTADKTDWVSRSAKDLKGAIGL\n",
      "FDIHTYPSKITVNSGEYEKIIKEYRKAAPANVPMIMGEIGFKFVEDEDSIYQKENLRRAA\n",
      "SKPYASVEDSQMYVYDHSYGIDMADALFQTINAGYSGCVVWMLDDAMHSKESPEKLKVWG\n",
      "FWNILGEEYFGESEESVRPWFYAWSLLTKYMPSGSRVLKMGNTGDKEIKAVALRYGNAYT\n",
      "IALLNIADEDKDVQLSTKNIQTSGKFQKFTYAKGNLQTSGDHELLADGYLKINESGIEHM\n",
      "SLKPGSLTVLTTLK\n",
      ">WLC65246.1_Clostridium_tagluense_B\n",
      "MEFKVFKGKSKLGETGIIILIFTIMWLLLLPLQVQATSVISVNNNKVIQEKFLGVNAVYH\n",
      "GFAYMPEEESKGMNDNYRKIEFNRVENMNLHIARTWYRPDFACGDDLMNNFDWNSVKMKA\n",
      "FYSWCQKMKDRNVDIAINPWWSSGTNADVWWGGQSYQWKVYLPRFSEWLSESINQLVNVR\n",
      "GFTNIKYVMLLTEGSQGYLDTEKPSGFLSLWDWHRNIIKEVHIKLVEDNRRNLVKIVGPN\n",
      "NGNGGEHFEEALLGCSNEIDILSGHNYDLHDYNAWYDEAKKMVDYAKLINKPMWFDEYGE\n",
      "TDKNLRSSPLYGNYIAQAVAGFMNAGCATSMLWLLFDQGYPYPLDKISNKDSFYNGIHEW\n",
      "GTTYWLPESMEPRPSFYAFSMISKLMGGTGTKVYETTCSSDVYISASKQLDENWSFLIVN\n",
      "GSNLEKDISVNLSIDINKKLYRYLYDPTLMQTNVKSKIISHDKVFNKVLNNFTDTIPPKA\n",
      "VVIYSSINDSHKGLSVLNNINDTFKFVLSCIIVLSILLIAVVVSKIIPRR\n",
      ">QTH43817.1_Cohnella_sp_LGH_B\n",
      "MTRLKLSFVLGLIVALTLGSLPYYESANKVYASSTVDIELRNNSPAYGGTTLGMGGTIMP\n",
      "FGYHASWQVKDFNDDDLAAIMTQFKKTGTTVARLWLDGSWWEPENDNNDPDVMLDSGFTW\n",
      "DSIEMRSLYKYLEAFKAMGVDVFVDVMVDDPRVMYPWLIAENKVNTGPNVGQIPEYAEHI\n",
      "AAMVKHLVVTKGFTNVKYVSFSGEPNNFFLAPPGVSKLDNYKASMTAVHDRLQLEGLLAY\n",
      "VKLIGPEIGYSDHDTAAWLDDLSLNIPSSLDAYTIHSGQTKAEATDGSYVALLQSFIDIV\n",
      "KSNDPDGADKPIMITDYTPTGTIRRPEDGLNAVALIANGLRTGVSEFGRWSFADDIWTWP\n",
      "PGSNQTSTSFGDYGFGMIGSKQENFTPRPNYKATALAYKFVPRGSTTYEAVTSDEAVIPA\n",
      "MIRTAEGKHTIIAVNWSDNDANVSFALDSALNTTFKKYRFSSASLDLVDKFGEIPSSFGT\n",
      "KTVNGVSFTDTVPANTIYFYTDIPDDSAPGQVTGLSAASADFKKATLSWTAGTEADLSYY\n",
      "RIYRGNTSGFAPSRDNKVGEIWIPAGDAPAFNDRNVEQGQTYYYKVSAVDTSENEGGYSS\n",
      "EASVTIGSETYSNTLSMTDSTDYDYYEIDSDYENGYKVRVYKNAGVIGYVQDKLGYNRQN\n",
      "LGLDIFSAPMVFKYDANAYSDKIVNGGAENGTTAPSDWHSWNNANGTFTWDSSVKHSGSR\n",
      "SLKIHNSAQTANSTWYQQTTNFVPGKHYEASYWIKTDNLIGPNSAGRGAYLNIQFLDSSG\n",
      "NTIRATGGADAYSNVGTQDWTYFTSDVTVPLGTATIQIGANLYENSGTVWFDDIRFEEQP\n",
      "EVALAGQHGGYYAADSVTAQSISATHKQIVTVAGDETMVYDFYPDRIEMKVQGPNPGGYF\n",
      "VEDGGIVPRNVTTAYWSDGSANTLSDTYAGTLIEKTTISLAFYQPPSPQTIRYEFGSPKP\n",
      "LTVKNGARFRGYYPRFQIDSNEAFTLKFPKKIDNPNGGAENGSAAPADWTMWNQSGHGAL\n",
      "TWDAGTFHWGGKSLKISHASTDNSAWYAQVEVSAPTPSIQLSAWIKTSAISGSQGAFISV\n",
      "EAKDAAMNVLATYRTPFVTGTTDWKRYALSLNPPAGTAYLFVEGNLFAATGTAWFDDFEL\n",
      "NSADTGIANPGTEVGSGSPADWWSWTSSGTPFEWDGTTYYSGKKSLKITNTANQTSTWYT\n",
      "KRSNLQMSKEYEFGGWVKTSGVSPGSMGAQLQAIALDSNGKWLQANIAPNVLHGTNDWTY\n",
      "VSGKITLPPMASSLQLEAQLWGVNGTAWFDDLFIRLVDKS\n",
      ">QHS51394.1_Edaphobacter_sp_12200R103_B\n",
      "MKNVLCFSLLLIAASLATAAPAQPSEHPKNVPQEMKVDLSAQPLGKFLGLGVQFDPYVNQ\n",
      "VDAHRWAEMMDHLAYMKPGFLRVMSGATDYCSGFDAKGEPIYRWDTDPTARQFQAILTVL\n",
      "DFAQAHHIEVYLGEWSPPGSLGIHSPDDPRWQRIISDFVQYLVRDRHYTVIHHYIFMNEP\n",
      "NGDWMWHGRKPDFTSWSTGVRNLRHQLDARGLDDVILTGPDNSGGRQWFDRTVTEMHDVF\n",
      "GTWEQHIYAKDQEVESGTLERELISDRETILKHDPDGASKPRFIAESGLVTGKIQAVDQQ\n",
      "PRVHDFDYGARMADYIVQVARAGWGGADAWDLDDAMHRGPGGGWKIWGFFDSNSDAGMKP\n",
      "RPWYYAWTILSRSMPNGAEILPVTGSSETPVRATIAKWNSSGKTQWTLVLVNHTDASASV\n",
      "NLKLPKQDELHVFRYFATEQNVDGALEPKESELEENPQRSQTVSLPSRGVVVLTTATAGT\n",
      "GSAARQAVLNYLKDISGSKTAVGVQNKDVANLTRDTDRIAALTGKQPSFWGADFSYGPRA\n",
      "LDKNREAMIKEAIAQYKAGALVGLMYHACAPILPDETCDWNSVGGTKPVHLTDAEWSQLT\n",
      "TPGTVLYKTWIARLNKLSVYFQQLKDADVAVLFRPLHEMNQCVFWWGCHLGPNGSAKLYQ\n",
      "ITHDYLVNTKGFDNIVWVWNVQDFNTLDTDVNSYNPGSSYFDIATLDVYNTGYTQNNYNA\n",
      "MVGIAEGKPIAVAECQYVPTPALLARQNRWVYVMLWSDFISNPRNQIALPALYHSPNVVT\n",
      "LDQMPGWGTR\n",
      ">QWG05959.1_Flammeovirga_kamogawensis_B\n",
      "MVKSKFRTNPITVFICTLILCLSSCSESELPTTILTFDNSEVINTNFLGLGVQWSTYPHA\n",
      "DANQDKWGNIMMDKKRWEFLYKRLDYMKPQFIRILDHAEQRYFRGIINQSTPNINFDRME\n",
      "MHALYQVLDYCQENSITVIMGEWNPPWQLRNNQYSIWVKMIGKYMHHLIVKKKYTCIKFY\n",
      "SLINKPNTITANTKGDYNQYHTAISLVKKEFEKVNINQQLSLLGPSIDPLLHYSKNGLTS\n",
      "LDWLQKSLSDTVYDAIDIQVYPSENNILSNSLSTVFNLDKKIIKQKNKPLIISEFGIRPQ\n",
      "KNSEESYYNDSLIALDEHASRLSQMKVYQNDYAIYTSDAVIQLLQAKADGIIAWHLDDAM\n",
      "FTEANDGNKNQLIKYGMWNSLSDTLFNNPSDMKLRPWYFSWSWISKNLPRGSQVIKLTNN\n",
      "NHQKIKGVGTINNNDYVILLSNLTDRDEYVEINFTDNIVDKTFYSFSIGQDDTILKFNSM\n",
      "ILPKNKHHRIGINHPLFVKLSAREMLILTTKK\n",
      ">ANQ50808.1_Flammeovirga_sp_MY04_B\n",
      "MTLKRLLLSLLSISIIFCLSTCKKGKPTSKLTFNKKNKINHDFKGFGIQWSTYQHADAPG\n",
      "DSWGFLMKDSSRWNLMFERLQHMKPSIIRIIDNAEDRYFRGLDPKGKPIVSYNRHEMHAL\n",
      "YKILDFCQQNSIQVILGEWNPPWQMQNGNEHLWTEMIADYMYHLVRVKRYSCIKYFTLVN\n",
      "APNTYKAKNQGDYDVWKNWVIGLENEFSKYHLNKYVTIMGPSSDPTWDMPLKTLKGKDWL\n",
      "AQSNEDLKETIGAFDVHAFLDEEAVIDGRTEDFLHLNPNEIQNLHGPLFISELGIKPMGD\n",
      "VLKDGRSSRLSQPKVFDEEYAELTTLACMDLLQVGVDGIVAWYLDDAMYTEANDGNTEQI\n",
      "MRWGMWNSLGDTLYHDPSELKIRPWYYTWSLLSSNIQKGSTIVQINNNNHQNINAVGVVN\n",
      "ARNEYVILLSNSTSEEQIIEIDFTEGLDNEEFYCVRMNHKKKSDGNSIILPKNDDIELVD\n",
      "NRSLLVRLSNKEMKLITSGEFLYSFK\n",
      ">QWG01382.1_Flammeovirga_yaeyamensis_B\n",
      "MKLLTKVFLSGIITTTFLSCQEEKQHQYFAKIEADKYISKNFIGNGIQWAAYPHADGPNS\n",
      "EWGDLITPAKWDTIYERLDYMQPQTMRVLDQANWRYYKGRDQKGQPIFDIDNPEMKTLYK\n",
      "VLDYCQTRNVDVVFGEWGTPFHVHDLHIKNAKENRFENAYDPQWISLIGQYVEHLIVEKG\n",
      "YTCIKFYNHINEPNGDWASTNGDYEEWKKGVIDLQKEFEKRGLDKYLSITGPGTVPQYTK\n",
      "KGFDYTGEEWVTKTIADIDTIVGAYEIHTYLGTDNTRNGKAAESMHMLMDMPEVNKTGKR\n",
      "FFVGEIGIKDEWDSKYQELNVEAAKKDGYASIYDSQMAVYTYQYGVDMADAVIQLMNAGA\n",
      "QGMIAWDLDDAMHTKDDLGKVDQLKRWGCWNILGTELIDRPEDENIRPWFYPWSWLCKYF\n",
      "PKGTDIHTMDTQLPEGIRMTAGKINDDYSILMVNNSDTLQNIAVSAPIQKSVKLKQLQYT\n",
      "ADDYKLNTEMGRPALNNTDLDLRKGGVVPLPARSVTILSSL\n",
      ">UII20690.1_Fulvivirga_ligni_B\n",
      "MKRLLIYPLALAMGLAACQSTNETSSQKDLVSIYPDQVISDEFIGNGVEWSAYPHADADD\n",
      "AEWGLLMTDAKWQKVFDRLDFMQPRIARVMDQANWRYLEGFDDKGEPILNFESQEMKSLY\n",
      "KLLDYCQEHNVTVILGEWGQPYKVHDPQLHMEDKFTGANDPNWIKIITANLKNLIQNKQY\n",
      "TCIKYYNLVNEPNGYWASTDGDWEQWKEGITMLNTSIKEAGLSDHIAVIGPDATPYNNDK\n",
      "SKYTGYNWAIEAVRQLGNVLGAYDVHDYPQKDFVRSGEFGQHYKEMVSFADSVNEKPFIF\n",
      "GEIGFEKYVEGNIKRYEADSFASPDSQLGIYDYDYGVDMADAVIQAMNAGFDATLAWGLD\n",
      "DAMHTNGDSGDKHQLKKWGMWNILGTELTGDSTEENIRPWFYTWSLMCRYFPGEMNIVKS\n",
      "DSVPAKNVRMTAGVFGKYMSMAIVNNSDSTANFTVHPGNLGEGATFKKFLYTEKQRHKDE\n",
      "NGFPKPVETDLKGSTALEVEVPARSFVLYTSYNY\n",
      ">UII20686.1_Fulvivirga_ligni_B\n",
      "MKYLLTLTFLSLICWACSHESPTDATITINSATVINDSYIGNGAQWDPYQLNYGDTTLQI\n",
      "SSQDWDKLYSRLDFMKPQLMRVMTNTRNSVRDGKLQPELHFSNLKPILDYCQTHNIQVLF\n",
      "GDWGGDMVHSKENKIDSANLHFAAEYLDFLINQKGYSCIKYYNMINEPNGFWSATDGNYQ\n",
      "LWANAIRFLHKGIVDLGLDNKVALVGPDAAIWSGEEAWWADSCATHLSKEVGLFDIHTYP\n",
      "SKVTVNSGEYTDIIKAYEEKVPEGKKIVMGEIGFKFVEPADSAFNKENISRAEAKKYAST\n",
      "DDSQMFVYDYSYGTDMADALFQTVNAGYSGSIVWMLDDAMHSKEAPNKLKVWGFWNIFGD\n",
      "EYFGSEEENVRPWYYAWSLLTKYMPQGSQIFEVKSTGDPSIKAIALNKNGQYMLAVVNVS\n",
      "QESHSVKIQSTDLKSLQGANKYIYSKNTLKKEGDHGLLPNETDLNINLSEGVSLDMPAES\n",
      "LIVISTFKNE\n",
      ">WPO86937.1_Herbiconiux_sp_KACC_21604_B\n",
      "MRRDVRRAALAAIAVGGLLVGALAGGVQAATAAPGGDQPVDVVVHTGDLVQDDYLGVGVN\n",
      "VIPWSLMGDTATLGYDEADWQVDVERILTLRPKVARFWFQIDWMELQKGQYDFDSPEMKA\n",
      "VYRYLDAFKQAGTEIELNFGWKVGERIHDWFTIPGVEDPYISAPADLPAYGRSASALLQN\n",
      "LWGRGYENVKYLTYYNEPNGSWDFEAPGDEKAYYAQMAQAVSDQLVADGIRDRIEIWGPE\n",
      "EVSAPDWTAFMEQNAPDAFDGYSFHLYGEAYSSLDDIIAARTSVANGKPVSMTEFGWASP\n",
      "EASVWETGYANYVIDSANKGVHTNLVWQLNGVMTDDPRGDTNGDYNLWDSVILGLEPSPA\n",
      "FYEAGPLLRYIPAHSSVYATEVSSPDARATAFRDGDGEWTVLVETKDGAAKDVTVRFDGD\n",
      "KSREASKGSYTRIAMTDADAQPEQNALLPASSGSLKVKKGAFTDREVTDAHTQLVYTQAP\n",
      "AQTQVALDDPQIEVVGGSTTKLGASVIDGHANVTWSVIGSDDGTVSPSGKYTAPQVTTER\n",
      "TVAITATSRSDGSSYAVQQVLVTPAHRDGVTDAPVFSLPAGQYDSLEGVTITSPTEGASI\n",
      "HYTTDGSQPTAESPEYTGQIVLPALKTTYLRAIAIAPGQEASGTTSRLYKVLDVQNAPDG\n",
      "YTFCAYDGQQCAFDGEQSVVYGSDGLFAYGTFAGGVECTAEAFGSDPNPGGDNRCFVNPV\n",
      "IPDEVPAVTVFNAGFEKPATSSAANGPMVNGWTFSVRSGVQSNTSPFVPAFPAPEGERTA\n",
      "YLKTDSGLASSIEQTVRFPAGSYAITFQAANRSGFGGQQEFDVTVDGTVVAHVVPSMTGE\n",
      "YALYTSDTFTVEAGEHTIAFVATTTDGDNTAFVDQVAVVSAP\n",
      ">WPO86936.1_Herbiconiux_sp_KACC_21604_B\n",
      "MTRTFLSRGLAAATAVLLSSAALVAVTAAPAHAADAVTVSIDPDTVVQSDFLGIGVNVIP\n",
      "GSLMEGTTELGYTDADWAIDSARIEKLRPKVARIWFQTDWMEPSKGSYTFTSDRMLAFYR\n",
      "YLDAFQAAGTDVELNFGWKVGSSIQSWFSIPGVDPWTSAPDDIPAFADAASALLDELITQ\n",
      "RGYDNVKYLTYYNEPNGSWDFEAPGDQKAYYLAMAQAVSDQLETDGLRDDVEVWGPEESG\n",
      "APDWTSYMAANGGDAFDQYSFHTYGDSYSSVAGSIAARTSVAGGKPVNMSEFGWSSDTAS\n",
      "GWDSGYANYVIAGANQGLHSLLVWQLNGVWTADPDGDTNGTYNMWDSVLLGLEPRNTFAA\n",
      "AGLLTRYVPAHSDVVQATSSSGDVRVAAFRDADGEYTVLVESKAGADKNLTVDFGSLDLG\n",
      "SDVHRVEYTPDLVPDENALLPASSASIPATTSFSDTLGGDYTVAVYTTADPAVQVALDDV\n",
      "DPTVASGSTLQLGASVVDGAAGVTWSVEGTGNGSVSSSGVYTPPAVTTERKVAVIATSTA\n",
      "DPSATAVARVLVTPASDPAVVSPPSFSLESGVYDGARMLTLSTATAGAEIRYTTDGTTPT\n",
      "ASSTLYEHPIVLAESTTRLYQAAAFAPGLTASGSASRLYKVGAVSDGPDGYTLCADENGT\n",
      "CFFSGQQSVAFGGDGLFSYQTRTGDTACTTAEFGDPNPGVEQHCYVSPTIPAEYPIVTIT\n",
      "NAGFEKPGGTKSKTGPFVNGWTFNNRSGIQNAQGPLGPGTPPEGAQVAYLKTDAGVQGEI\n",
      "SQELTFPAGTFQLAFELSGRSGYPAQTFDVLYDSTVIGSFTVSSTTSYTPVRSAIFASAG\n",
      "GKHTVTFRATAPSGDRTAFLDDVRVELPAAPAVPALANAGFESPATTNVKSAPFTDGWAF\n",
      "VGKAGIQHNGSAFGATTAPEGTQTALLQSKDGSHGSFTQSVDFVPGDYRLTFQASKRAGY\n",
      "ATPQPIEVLVDGTVVATATPSASSWTGYTTPVFTVGRGAHSIAFRGSAPTGDATAFVDAV\n",
      "GLEAVPAAGLEAATTAAAWSLCVGTEAYVAVYSINKAGRDVDMRLGAVGAEKEETGVADG\n",
      "TAAYGLFPSGASTLAAGTAEVEASYLDGTEHTSTQTPSYAALDCSAEEG\n",
      ">WEV39865.1_Lactobacillus_sp_ESL0681_B\n",
      "MKHKKIKLFTILSVVTTLMAPILAPVTTSVAAKSATNQKKTKNELTKYDRKWQTYNSNDS\n",
      "DVKLDYHDDEVIASFNKSNGKDYWDSQLFLPDIKLANGKYQLSFKVKATKPSSIYFDIED\n",
      "SNDYQTKYYPEKLLDLDTQYQTKTINFDLKDQSILDDKKQIKLQFNLGPNENTKSLAQQK\n",
      "LTFADFKLVKKANASKVKKQKASFTVNGDNVLVKDYKGFGVQWDPYTARPVTDQEWTMIT\n",
      "KRVDYLHPSFVRVMLYANTYCKGLDKSGNPIYDFDSKANQALLRELRYLKQKKIPVILGE\n",
      "WEAPGRFNGAFSGINADNPKWAKIIVGFLNYLVNEQGFTNIKHFNYINEANSDWSYCADY\n",
      "DKWHQGITYLYDELSKYQLTDKVTITGPDTVWDDQNSWLHNIANDHDFSQKLGLYDTHMY\n",
      "PSVEEITDGKVEQQVAEQRSVVKGKDFYMTELGLVTGKTNGDSQSYIRDYRYGILMADAA\n",
      "AQVARGGFNGVSLWDLDDAMHDQDNGFPSSDIRSLKQWGFWNSVGGRLYNEPKEEQIRPH\n",
      "FYTWSLMTKLIPPHSEILGETKTGKSAGFRILTAKKGKDVTYVLIKDSNKSGSLKLKSKN\n",
      "LSKTKQKFYRYNYFKNQRKVNTNGFPVATSKKTIKLNHGKTFNFSGPGVIILSTKKVK\n",
      ">QHO70380.1_Marisediminicola_antarctica_B\n",
      "MVAVLAVSLAAVTDSADRSFADSLSGSSAVSVVVANSTTGVVKEGLGWNAENVWQSENKI\n",
      "DGGINWGTTQWDQYNNMVKFLNPQVVRLGVQVPYWSPSYGTYTWNSSWMQNLYQQLDAYK\n",
      "AAGVTVMLSNWWTSSNYPDNFWWSETSRNGTTDPDSFKRNDLPYDNAKFSEALVAGIKHL\n",
      "TVTKGYTNIKYLSAWNEPDWNFVSANASYPASATSGSNTFWPLYTSIGNALTTAGIRSQV\n",
      "SIVGPETSWIERFGPNIKTYVKTPAAGQPQQFGQVVDAIAVHDYDSFSDHDTRTYDNARD\n",
      "YFTATSTIGRVADIKTSVNATYAAAGKPAPPMFVAECCNTAYGAAYINDASAVTDDGLFS\n",
      "AEMSARYLSSGVDGVMRWNLTTTSQGGLPYETGFVPITYDFPSQTFSAQGGSYYSAAILS\n",
      "RYLSKGASVHSTTVTGAGSPARVFATALKRADGNWTIYLVNNDYTDRQADLDLSALGIPT\n",
      "STPLYQYEWSSGNPNGILAKQALTYQGRTFNLPLAPRSVSTFTTLGSDFTPQSMLTVNQA\n",
      "TGGVTATSVAAPVANSGFETGSSSGWTTTGSVTVQNSPVWANAGSYVGTLNSSVGAAELA\n",
      "QTLTGLSAGSYVLSAHIRTAGTNTATIGVKNFDGTKNYSQDVTSSVYRSASVYFTVPTGG\n",
      "GSATVYVKVPAGSSGTFVNLDDVRVVRIANLANGGFENASPFYWTASGSASRQAVTSARS\n",
      "GGVVGTISTSTGAGSFSQTVNGLAPGRYSFSGFVRGSAGITSSISVSGYGGATVTASGTS\n",
      "SSWQRVSVPFTVTTANSTATVTYSAPAGSAGSYSNGDDFEVKRNPSPQPNYTDLLADFSK\n",
      "MSSHSANLAFDGANSEFLGYNSHRLVRSSNTAAYVAYTVPSGTTMKGFVVSSYFWPGEAI\n",
      "ANFQFATSPDGVTYTPIAPTQTAVPDPIGTNWTVVGYTNSTVPAGTKFLKITFANTTANY\n",
      "WNPQLSSVQIFH\n",
      ">APF34734.1_Microbacterium_paludicola_B\n",
      "MKRRIGAAVAAAATVIAGSVSVGALGPVSPATADDTAPAEQRTVTVALDETVQEDYLGIG\n",
      "VNVIPWSLLEGTTRLGYDDADWEVDVERILTLQPKVARVWFQIDWMELEKGQYDFDSPEM\n",
      "RAFYRYLDAFEQAGTEVLLNFGWKVGERVHDWFLYPGVTKPYESAPGDLDAYGRSASALL\n",
      "DELINARGYDNIDFLTFYNEPNGSWDFEGPADQKAYYAEMARKVHDQLIADGLRDEVQIW\n",
      "GPEEVNAPDWTQYMAENAGDVFDQYSFHLYGESYEFLGNAIDQRRSTIGDAPLNLSEMGW\n",
      "TNPGTSVWETGYANYIIGSANNGIHSNLVWQLNGVMTHDPAGDTNGSYNLWDSLVLGLEP\n",
      "TAAFYEAGLLMRYIPEHSTVLGTETSHDDVRATAFRDRDGELTVLVETQSGSPKDVRVEF\n",
      "TGGDVTESFTRLAYSDSIVEREKNALLPASSGTLTPTSNAFTDDAIGDENTFAIYTTSPA\n",
      "ATQVAVDPVESTVAGGEQLDLDARVIDGSGDLTWSVVGDDNGAVDADGVFTAPDVTTERT\n",
      "VAIRATLDDGVYGVAQVLVTPASEPGVADAPVFSLEPGLYESVEAVSITTGTPDAEIRYT\n",
      "TDGSVPTADSTLYTGQIVLAPLKTTYLRAIAVGDGLEDSGVTSRLYKVRDVQNAPDGYAF\n",
      "CQYQDRGVCAFEGEASVAFGSDGLFRYGTFTGGVDCTAASFGGDPNPDGDNRCFVNPDVP\n",
      "DEQPIVTIYNAGFERPATGGTSNGPMVNGWTFSARAGIQHNNSVFQPAFPAPQGERTAYL\n",
      "KSDSGLASRIDQTVRFPAGTFAITFAAANRVGFGGQQEFDVLVDDQKLGHFVPTRDGKYT\n",
      "AYETEPFTVAEGEHTISFVATTTEGDNTGFVDDVQVIAAGTPDPEPDTVKPVVTLTAPTT\n",
      "AGPHRSLELKVDATDDRGLARIVANVYRDGTLVKSTQTAVDGAAAATHAASVTLPDGTYT\n",
      "VRYNAHDLAGNVAQTKTFDVTIDATAPTVTVKDGASFTARDGDDYSLVSFKLRDAGKIDK\n",
      "AVLNGVTKDLTDNAWSDVNFVKPGVFGAVPGANTLVVHDVAGNTTTVEFTLR\n",
      ">BAJ75160.1_Microbacterium_testaceum_StLB037_B\n",
      "MTSPHPLRRWTALTTTGAVIASLAVAGSVSSAAADTSATVTIDTGTVVQDDFLGIGVNVI\n",
      "PSALMERSRGFGYSDADWAIDAERIATIRPKVARVWFQIDWMEPDKGVYTWDSDRMKAFY\n",
      "KYLDAFKAAGTDIELNFGWKVGSTVHDWFGIPGVDPWTSAPADNAAYAASASALIDQLKN\n",
      "VRGYDNVKYLTYYNEPNGSWDFEAPGDQQAAYVQMAQAVHQRLVADGLRDEVEIWGPEET\n",
      "GAPAWTTYMAQNGGDAFDQYSFHTYGDSYGSVPASINARKSVAGGKPVNMSEFGWSDDNA\n",
      "SGWDSGYANYVIAGANLGLHSLLVWQLNGTWTVDPDGDTNGTYNMWDALPLGLEPRKTFL\n",
      "SAGLLNRYIPAHSQVLQSSSSTSDVRTAAFRDAAGEYTVLVEAKGTAPTDLDVSFGTTAV\n",
      "NKDFHRVVYANDLVPDKNALLPTVSATLPAATGFSDQLDDGYSFAIYTTAAPAVQVRLGD\n",
      "VDPSVASGSTLPLTAEVLDGAPGVTWSVEGTGNGSVTSAGVFTPPVVDSERTVAVRATST\n",
      "ADPSSSAVARVTVTPQLTAGRVDPVQFDLDSGVYAGSEVLTLSTPTSGAQIRYTTDGSAP\n",
      "TANSTLYERPLILAETSTKLYRAAAFATGKQDSGVTSRLFKVGGVSQGPDGYTLCANEGG\n",
      "TCFFSGQQSVAFGGDGLFTYQAKTGPVSCDAATLGDPNPNGTQRCYVSPELPSSYPLVTL\n",
      "TNAGFEKPGGTKSKTGPFTNGWTFNSRSGIQNGQGPLGPPTPSEGQQVGYLKTDAGVQGT\n",
      "ISQEAAFPAGEYQVVFALSGRSGYPAQSFDVLYDDSVIGSFSVGSTSSYETKRTPAFTSA\n",
      "GGRHTITFRATAPSGDRTAFLDAVRIEAPVPPEPAQLQNTGFEAPATTGVKSAPFTEGWS\n",
      "FVGRSGIQHNGSAFGAPTAPEGTQTALLQSRNGEHGSFTQTLDMAAGDYTLSYQASRRPG\n",
      "YSAVQTVQVLVDGVVVDSFAPPTATFTAHTSATFTVPAGDRQITFRGSAPSGDATAFVDQ\n",
      "VVLTPVP\n",
      ">BAJ74095.1_Microbacterium_testaceum_StLB037_B\n",
      "MRRRRTALALTATTSVVAAALLVPATAASAADEQRTVTVHLDQTVQEDYLGVGVNVIPWS\n",
      "LLEGTTKYGYDDADWEVDVERIHTLQPKVARIWFQIDWMELEKGRYDFESPEMKAFYRYL\n",
      "DAFKAAGTEIELNFGWKVGARVHDWFTIPGAPDPYISAPADLPAYGASASALLQNLFDRG\n",
      "YDDVDHLTFYNEPNGSWDFWAPGDEKAYYADMARAVSDRLTADGLRDEVDIWGPEEVNAV\n",
      "AWTQYMAENAGDVFDQYSFHLYGESYDAMGDAIAQRRAVIGDAPLNLSEMGWTNPGTSVW\n",
      "ETGYANYIIRSANDGVHSNLIWQLNGVMTGDPAGDTNGSYNLWDSLILGLEPTAAFSEAG\n",
      "PLMRYVPTRSTVLGTEISDADVRATAFRAPDGELTVLVETQSGSSKDVRVQFEGGDAAGD\n",
      "FTRIAYTDAIAQPGENALLPASSGTLTPDANAFTDTEIGDEHTYAIYTTAPAATQVEMTP\n",
      "VRTSVAGGSRVQLGANVIDGTGTPTWSVVGSDNGTIDANGVFTAPSVTTERTVAVRATLA\n",
      "DGEYGVAQVEVTPASTAGVTDAPVFSLERGVYDSIEAVTITSATPDAQIFYTTDGSEPTA\n",
      "SSTPYTGQIFLEPLKTTYLRAVAVAPGADASGVTSRLYKVRDVQNAPDGYSFCQYAGGGE\n",
      "CAFEGEANVAFGSDGLFVFGTFTDGVDCAVASFGSDPNPGGDNRCFVNPDVSEEPPLVSI\n",
      "LNAGFERPATGGTANGPMVNGWTFSARAGIQHDNSVFVPASPAPQGERTAYLKSDSGLAS\n",
      "RIDQTVVFPAGTFAITFAAANRVGFGGQQEFDVEVDGQKLGHYVPVGGDYRYYETAPFTV\n",
      "TQGEHTISFVATTTEGDNTGFVDDVRVVAAEEEPGDTTAPTVTVKEGAAFTQGTAEAYDK\n",
      "VSFKLYDEGKIDRAVLNGVVKDLADNTWSDVNFVAPGVFGAVSGENTLVVSDVAGNSTTV\n",
      "TFTLR\n",
      ">AHF17862.1_Niabella_soli_DSM_19437_B\n",
      "MKSINMIKNTFILLTLVVLMANCSKGSASNKGTDNGGEAPGEQVTIDVTKTVSANFAGFG\n",
      "TQYNQNVYAAISAVDGITTANIGQLEAKVKALKSRYVRIFFDSRAWPADPGYSTATADFM\n",
      "TSFLKTVQLAQDGGAATINITFWHTSTPEEMPAFADILKELIVTRGLSSVKEVTIQNEPN\n",
      "STSMTMDYYKTCYTALDQALTIRGIRNKINFVGGDLVQTNQQAWFGYLAANMGDLLSGYS\n",
      "THIYWDDNDAAKPMTRLTEVAAIVKAPGSANKPVYITEYGVRGGNKTGAPDPGYLTGTST\n",
      "PIAQTPVAAMQNALFQINGLNLGFSGFIRWDCYKAKYDNGTQYFSCIGSGTDGYPLYPLY\n",
      "YMTWLFNHTSEPGWRVVSSYPTAGDNRPIIAAAMINATASEQTIYVINKSSGQVAYTAGG\n",
      "LIPNKKYTVCSFNNNNNGQLEKSEATAGGDGKILHTIKPNSFVAITTYDLTLP\n",
      ">AHF89993.1_Opitutaceae_bacterium_TAV5_B\n",
      "MTCSESSGIRVPVFAILVACLPFAAFSSRPLVAQDKPSPDARQERLVVAETTGINPLDGP\n",
      "FIGFGAQWDSTAYIRNGITDADFDLIEKRLGWMRTPIVRMMMVSGWCYQGNGRYDWDSPQ\n",
      "MRMVLRQLDVCQKLGISVILTEWGYNTRWMRTPEVSDIGDPKHVEIIGSYMEYLVKTKGY\n",
      "SCIRYFGYVNEPSSSYAQKQDLWLQGIDGIAAEFRRRDLADKVRLVGPDSASLALAMFDR\n",
      "KSWLAPLQKRAASVGAYQFHTYIVLEDMRRGGLKDLYSEAWRQVREGDPDKTKPLIIGEA\n",
      "GIWKWGPTRETKTGADNNAWNREDPWAYGIYMAEYAIQAIEAGSWGVLAWMLDDNSHYGF\n",
      "NWGMWTSKKDGMQLRPWFYTWSLLSRSFPPGSEFSKVYPPPVYSNMRILAAKLPVRTGDA\n",
      "KQAGAGREWAFLIVNTGTSHSRIRVRVPGGHVQKSDVYSWSRNAASADADGFPRPSTTLE\n",
      "SSLDEGFPMSFPPQSVTIVVPQGRDERI\n",
      ">AHF91408.1_Opitutaceae_bacterium_TAV5_B\n",
      "MHHKNHVSLKLAAAPVHRMQSGVGASWHSILNAPVGHGGSAFGGQPPVLPVHEPLWRSIE\n",
      "AQADWLKLRFIRLEFEWRQFEPRRGEFTWDSPGMRILDRICAWAERAGADVMLQQQWGGV\n",
      "AWNSFPEFRGDPAMETYSAPADLHAFADGWMRLLEELSVRRGYRCIRWINPINEPGYWWW\n",
      "HLPESYRLLRVEGNREASRRLQLSYLAEACAILRRRLRAEHPAVRLMGPDETDLPVYERL\n",
      "AAEPWFAAVDDVDFHSYNSVFDHEPLPAAWNYHIGDRIDSLVRRYCDEAHAAGKGLFLTE\n",
      "VGSMAYGYGADNPAPGCHLSSLKDVEVLIRSLAAGVDGFSHWSFTNRGDIDGQWQLVDTW\n",
      "SIEHKNWLPEARPHRPAFDVLGRAMRHVPKCARIFPVEVDGGRIGQPPHRRVWAVAAQDP\n",
      "STGVTRLLVVNNAEEPFEFTLSLPETRRGDGTASDAGAGAWSVLDPCSDKATPLDRSLRD\n",
      "SRCRSGVLPPRQLVILSNGAATPEERSLPARYLPQHDIAKRPANASDSRLAPSHLHPSSV\n",
      "IQSAIP\n",
      ">WFR61027.1_Paenibacillus_amylolyticus_B\n",
      "MKSRSGRLASRWAIPFLISTMLASFVPAPSLIYANQNESQNLNRTSHTITMDTSDVIQDD\n",
      "FLGVGVNTIPTALMPGQTQYGYSEAHWEVDNKRIQTIQPKVARVWFQIDWMEPAKGTYTW\n",
      "DSAKMKAFYKYLDAFKAAGTEIELNFGWKVGSTVHDWFTIPGIDPWTSAPADLDAYAASA\n",
      "SALLEELILNRGYDNVKYLTFYNEPNGSWDFEAPGDQKAYYAEMVNKTSARLTADGLRDL\n",
      "IEIWGPEETGAPAWIEYMKQHADDAIDGYSFHVYGESYEGLGNAFALRKGYVGDKPLHLT\n",
      "EFGWADDQASNWDAGYANSVIQTANMGVKSALMWQLNGVWTNDPTGGTNGTYTMWDALVL\n",
      "GLTPRKTFYIAGMLNRYIPEHSEVLAVDTGGSNDVRAAAFRGDDGNYTVLVETKAGTEKE\n",
      "IKLDFGDTAVNQAFRKFVYNNDIVQEANAVLPPVAATFPGGTSLTDSNVDGDYNVIIYTT\n",
      "RPAETQIKLDEVNPTVRSGDSITLGAEVIDNTGSVTWSVVGQNNGTINSSSGVYQAPQVT\n",
      "DETLIAVRATSTADPSAYGVALVRVLPSSQAGKVEVPTFSLDRHIFPSSEMLYLETTTSG\n",
      "AQIRYTTDGSEPTAQSSLYVRPIVLNEGSLALYKAKAFKDGLQPSGTVSSLYQIGQISSA\n",
      "PDGYKLCMIENGGECYFQGKAVVAYGADGLFNYSIQENGVACTSAILGDPIPGVDKRCFV\n",
      "NPEIPDELPVVTFFNAGFEKPATTSARPGPMTNGWVFDSRSGVQHNNGPFQATAAPQGVQ\n",
      "TGYLKTDGGVSGTIRQSIHFKPGTYQMSFKAAKRTSFGGTQSFDIYFDDQVIGSYRPESG\n",
      "NFQTFRTEPFETAGANTRSNL\n",
      ">ANF97338.1_Paenibacillus_bovis_B\n",
      "MNKKARSAFSIMGTSILLLSLILPSVSAPSQAKAAEPTAATAVTRTISIDPDKVTHSDFL\n",
      "GVGVNIIPTNTMDLGARYGYNDAYWAMDVNRIQKIQPKVARVWFQIDWMEPEKGQYTFDS\n",
      "PKMKEFYRYMDALQSAGTEVELNFGWKVGKTVQDWFNFPNLKDPYVSAPTDLNAYAASAS\n",
      "AALNELINKRGYDNVKYMTFYNESNGSWDFEGPADQKAYFAEMSRKVSDRLKADGLRDRI\n",
      "EIWGPEESGALDWISYMKQNADSVFDAYTFHVYGTSYDGLKSVVDQRTSIAGSKPVVMTE\n",
      "FGWSADDASGWDAGFANSIIRAANDGLKGALMWQMNGAWTSDPDGDTNGTYTMWSSLPLD\n",
      "RMPRKTYYSAGFLNRYIPEHSDVLAVDTGGASDVRAAAFKGQDGNYTVLVESKGGEARNL\n",
      "NIDFGDNTINKTFYKMTYRDNVNIDANAILPQVEKAFAATRSFTDNDSDTAYHFSIYTTA\n",
      "KPQTQVEVTPVEKTVTGAGTLQLQARVIDATYNGQAAVTEDTYATENTANTDASTTRSTD\n",
      "TDASEAAALGEVTTLADQADSAASQASDRTDSGDSSVQVAGQSAAIADSTDVQAASSENT\n",
      "VNADTYAADDTQQSLAAAGGVTWTVLGTNNGTIDANGLYTAPDLASERMIAIKASSSQAT\n",
      "GAYGIALIKVIPRSVPNRVDAPTFSLKPGTYDSAEAVFIETKTPGAQIYYTMDGSTPTAS\n",
      "SSLYKYGAILPNGGNRMLKAIAIKPGLDNSGITAALYKTKDVAMGPDGYEFCMYEGKVCD\n",
      "FKGKAMVAYGADGIFKYKTFTDGIECTDESFGGDPAPGSAKRCFFTNTIPDETPVVTIFN\n",
      "AGFEKPGTETTRTGPFTNGWTFDSRSGVSANGSQLVSKDIKAPQGLQVGYLKTDGGVNGT\n",
      "ISQQMNFPAGTYELSFDLATRSGYGIQTFDVYMDNQKISSHTADSVNFQKVTTRPFTVTS\n",
      "GKHTVKFIATSADPALPKLDRTAFLDSLFIRPANSLPAQLKNGGFETPVIAADSKAKTKP\n",
      "GPFTSDWVFDSRSGVQGNNSVLGSVTIPEGAQSAYLKTDNGVNGTITQKLKFPQGSYTLS\n",
      "FKAAQRTNLRGTQKFNVMLDNQVLGSYTPASGAYEAFTISPFTVTAGEHTIQFVATSTTG\n",
      "DNTAFIDDVKLAPVQ\n",
      ">WPP43235.1_Paenibacillus_hunanensis_B\n",
      "MNRQARTMWRTLGVQVMTLALMLPAFTWGSADTNRAEAATVSRTISVDTSQVVQSDFLGV\n",
      "GVNIIPTNLMELGTRYGYNDAYWAMDANRIEKIQPKVARVWFQIDWMEPQKGTYTFNSDK\n",
      "MKAFYKYMDALKTAGTEVELNFGWKVGSTVQSWFNIPGLKDPYVSAPADLDAYAVSASAA\n",
      "LNELLNQRGYNNIKYLTFYNEPNGSWDFEGPADQKAYYAQMVQKVHNRLTADGLRDRIEI\n",
      "WGPEETGALDWMQYMKNNADSAFDAYTFHVYGTSYDGLGNVISDRHAAAGSKPVVMTEFG\n",
      "WADDDASNWNAGFANSVIRAANDGLRGALMWQMNGAWSSDPDGDTNGTYTMWHSLPLDRD\n",
      "PRKTYYSAGFLNRYIPEHSQVLKVNTGGASDVRASAFRGADGNYTVLVESKGDSAQQLTI\n",
      "DFGNTSINKTFYKMTYRDSVQPNAQATLPVVENTFAAQKSFIDNSTDTGYHFSIYTSAKP\n",
      "QTQVEVTPIEKTVTGGQTLQLQANTIDATYGNTSVAAVTEDTYGTETDSDSTSSETMKSS\n",
      "TAEGTRSNADEQAVAALSASEQVTSTVTASSVSKSGDSTANAVAASSEATATEQATTDQA\n",
      "TANTQAPDESTTSSDAKVDTDKEKGTAVADQTSATEQSAPSSEEASATEAESVTESTYTL\n",
      "AATNVTWTVLGSNNGTITSNGLYTAPDVSTERMVAIRATSSTAPGAYGIALIKVIPRHVD\n",
      "TRVDAPTFSLTPGIYNSAEAVFIESATAGAQIRYTLDGTTPTASSTLYSNSVILPNGGTR\n",
      "MLKAIAIKSGLTNSGVTSGLYKTLDQSIGPDGYQFCAYESKTCSFNGQAMVAYGADGIFK\n",
      "YKKLTDGALCTDEVFGGDPAPNAAKRCFYTTTIPNEVPVVTIFNTDFEKPETSSIKPGPF\n",
      "TNGWVFDSRSGVQRNGSAFGAATAPSGQQTAYLKTDGGINGTMSQQLNFPAGTYKLSFQG\n",
      "ATRSGYGIQTFDVYVDSQKVGSFAPQSSSYTTLTTNAFTVTAGKHNVKFVATSNTGDHTA\n",
      "FLDSMIIREASSTPDPEPPVTGELKNGGFETPAIASSSSTKTRVGPFTSDWVFDSRAGIQ\n",
      "GNGSVFAPAANAPEGTQTAYLKTDNGVNGSIQQQLTMAAGTYKLSFKGAKRTNLGGTQTF\n",
      "DVYVDSNKVGTFAPNSGIYTSYTTSAFTVTAGQHTIRFAATSTTGDNTAFIDDVKLTAQ\n",
      ">ANY71428.1_Paenibacillus_ihbetae_B\n",
      "MTSKKSMFALCRKGLLCAALLLSSIGAGTAAADSSLADSPASHTVRIDPGTVIQEDFRGV\n",
      "GVNVIPSSLMPGTTQFGYTDTDWEIDKKRIVAMKPKVARVWFQVDWMEKTKGSYDWESAE\n",
      "MQAFYKYMDAFQAAGTEIELNFGWKNGSAIHDWFVLPGVDPYISAPADLGAFARSASAAL\n",
      "SELIDGRGYDNIKYLTFYNEPNGNWDYETTGDQKAYYAEMVRKVSQQLSTDGLRDRIEIW\n",
      "APEETGAPDWTAYMAEHASEHIDGYSFHVYGASYESVTAAMNERIQAAAGKPVHLTEFGW\n",
      "SDDGMSGWDAGFANHVIQAANMGVKSALVWQLNGVWPTDPFGDTNGNYTMWDSTVQGMTP\n",
      "KKTFYSAGLLARYVPAHSTVVKVDTGSPDLRAAAFKTERGDYTIVLESKAGSRKEITFDF\n",
      "GGVKINKTFRKFVYSDDVIRDGNALLPSSSGAFKAKSSFRDTSIGPDYNVIVYTTEAPQT\n",
      "QIKLTPIEATVAGKGTIQLSAELLDNNGAVKWSVIGGEGNGTISSKGLYTAPDVATQRQV\n",
      "AIKAASSKDPASYNIAKITVTPASTPGKVDAPVFSLPYGVYDSAEAVTVTSSTPGAEIRY\n",
      "TTDGSIPTASSRLYTGPVILNNGTVQLFQAIAIKPGMQDSGVTSAYYRIRDISNAPDGYQ\n",
      "FCTYEGGFCDFEGEAVVAYGAEGLFNYAIHADGAACSDEVFGDPSPNSAKRCYYSKEIPE\n",
      "ELPLVTFYNAGFEKPATGNTRVGPFTNGWVFGDRTGIMHNGSVFENPDAPQGVQAAYLKT\n",
      "DGGVAGQFSQRIQFKEGTYQMSFQAAKRTSFGGLQTFNVYFDDTVIGSYAPSSGTYMTFT\n",
      "TDTFTASAGEHTIKFVATTAEGDNTAYIDDIRIGSPQPPKAPAFANAGFESPSTSGAKAG\n",
      "PMTDGWVFNNRAGVQRNGSAFGAAEAPEGIQTGLLQSKDGEQAEIKQSLYFPAGSYSIRF\n",
      "QAAKRGGFGGLQSFDVYVDDTRIGSYQPATTAFEAYTTDVFTVSSGNHTVTFRATTTAGD\n",
      "NTAFIDDVQIVVP\n",
      ">WCT54208.1_Paenibacillus_kyungheensis_B\n",
      "MKKKARSVCSSIGIAILMLSLLLPCFQSPLLAATSTAASAEINRTVTINTSNVVQSDFLG\n",
      "IGVNIIPTNLMALGAKYGYNDAYWAMDTQRIYQFQPKVARVWFQLDWMEPSKGTYTWNSE\n",
      "KMQKFYQYIDALKASGTEVELNFGWKVGSSIQSWFNFPNLKDPYVSAPTDLPAYARSASA\n",
      "LLNELINKRGYDNIKYMTFYNEPNGSWDFEGPTDQKAYFAQMSRAVSEQLKADGLRDRIQ\n",
      "LWGPEETGALDWTQYMKQNADDVFDAYTFHVYGASYNDLGARIAERKSAVGSKPIVMTEF\n",
      "GWGDDNASNWDSGFANSVIRAANDGLQGALMWQLNGAWTSDPDGDTNGSYTMWDGLPLGL\n",
      "KPNKTYYSAGLLARYVPEHSQVLAVNTGGASDIRAAAFKAKDGNYTIVLESKSGQSKNVT\n",
      "FDFGTTTIGKTFYKMNYQDDVQRDGNALLPAVENSFTANQSFTDSAINSEYNVSIYTTAK\n",
      "PQAQVKMTPIESTVASGSTLTLNATVIDASYSQTSVAADTYTTDDILPVTENDVKTKEKQ\n",
      "DIFNNYSTTTATSDTYVTPAEEYTLASASTDVTWSVVGSGNGTISSTGVYSPPDVTTEKL\n",
      "VAIKATSVADPKGYGIALIKVIPQSIASRVDATTLSLKAGVYDTSEAVTVKTGTAGAEIR\n",
      "YTLDGSVPTTSSSLYTKPVILPEGGTKVFKAKAFKSGLTASGVTSALYKILQNSTGPEGY\n",
      "QFCMYEGGTCSFDGTASVAYGADGLFKYGTFTNGVACTDEAFGGDPTPNLPKRCYYTNDV\n",
      "PEQTPVVAIYNTGFEKPTVSTTKTGPFTSGWTFDSRSGVQRNGSAFGATTAPEGQQTAYL\n",
      "KTDGGVAGSITQQLNFPKGEYKLSFKAAKRTSFGGTQTFDVFVDQTKIGSYAPTSGNYTT\n",
      "YTTNAFTANGKRTIRFVATTTTGDNTAFLDQISIQLASDISVPPSNPEAVIANTSFENPA\n",
      "TTNTKVGPFTSDWVFSTRSGIQRNGSVFNPAANAPDGVQTAYLKTDSGVAGSISQSITFP\n",
      "AGTYALTFQAAKRTSVGGTQTFDVYVDNKVVGSYSPTSGTYTSYTTNNFVVTAGEHTIKF\n",
      "VATTSTGDNTAFIDQVKLIQK\n",
      ">AYB42811.1_Paenibacillus_lautus_B\n",
      "MSKERRWLGGILSFFIFAGILTTPTSIQAEDNVSTINIDTTSVVNSDFLGIGAEYDPFHF\n",
      "MPESVEAGFNEHWWEMEKRRLAKVKPNLVRVWYQIDWMEPANDNNDPNIIDWSGMQTESV\n",
      "KMQAVYRVLDYLKAQDIDVILVAGWKMNADVRSWLGFSGLQKPETSAPTDLNEWAEWVSA\n",
      "TLQQLIVNKGYDNIKYVMSYNEPNLGDFETPASINQKEYYEDMYRAIHNRLVTDGIRSEV\n",
      "KLLGPDESSGLDWMQHAVQNMNDILDIYEGHAYGKEYDTMDSWTTERLALVEPTGKPLMT\n",
      "TEFAAPGDKTTYQNAVELADLMVSGMRSGNSGMLMWRLADQFLVDPLNFLDSSAYGTWPW\n",
      "LPDSAVPRYTYYTFSLFTRFGGAHSQVLLTETDDPDLHVTSLKRLDGEYSVFVVNKSLHS\n",
      "SKSVSIEFSNHVGKTFRRHLFSDAITPTASATIIPSDTLWNSVATSFNDASIPANSVAVY\n",
      "TSVPEPVQIEIAPDEVSAAPGASITFEGNVYGAAPGIEWSVAGGPTYGVIDNQGVYTAPA\n",
      "IVPSMPEALVKAKINGEQDFAVIRFQVTGASALGDDGSIKLNWSPSMGASGYNVKRSQTR\n",
      "GGPYSTIAGQVSATEYIDAGLANGQTYYYVVSAVSSTGEGADSKEVSAMPTSNAMEDDFN\n",
      "DNQIDSAKWSVINRGLRSSLPTQIVASEANGVLTFNGSTGINYWSGKAVESVLPFHASAT\n",
      "EPLTVQVDRISLSGTGTGQRSGLWLYVSGSEYLRFSQNKDTGVWAYNLNGGSDTLVLADN\n",
      "NLGNHEMKLVHDGSHVHIYVDDIKYKSVPVAWSSNMKVVLSAEARADGDSIQVVYDNLSV\n",
      "SSGSP\n",
      ">QGG55106.1_Paenibacillus_sp_B01_B\n",
      "MKAVEERLDGAGGLDGERMAAALDRAAVETAAGHEGPAAVGAEYSGLVAEAAPVVGRLDA\n",
      "AAAAWTVRIDADDVLVGDFDGIGFEWDPCDTYEHTDEQWETLLERVDFTRTPLVRVMLRA\n",
      "NAYTAGWDGRGEPVYDWETPMMRRLWRILDHCERRGIDAIVGEWSRSPELGLTASDDPAW\n",
      "AELIGEFLHQLLDVRGYRCARWYNFINEPNGDWATEDGDRFALWRRGMLQLAQVLERRGL\n",
      "AGRIGLIGPDSSNEDEWVELAVYGVGGLLSAYDIHRYVQDADLISGRLERQVREKRRFID\n",
      "RNDPDGAAKPYLMTEAGIVEGKNEAHDQQPRVRTFEYGVLMADFALQAMRGGQSGLIAWM\n",
      "LDDVMHHAKGYPWSSGEWKTWGFWNSSGDAQERALRPWYDPMALLSRLFPRGSRIVAASV\n",
      "WDDEGTGGAGPGTGGSGGVSVGEPGAGGVGGAGGAGPETGGSGSVSVGEPGAGGVEGAGG\n",
      "AGPGSWREPVLAGVRGVAALVPLDGGGRGWSAAIVSHRQGRQSLRLVLPQASGGADLAVY\n",
      "RCSERERSADADGYPAPALTLSGADAARGIELELYGPGVLFVTTAMPEDGPHGRQTASRQ\n",
      "TTLAAAGREPQRPEAFGLSWGVQPFAGEGDLARGRPASGSISLHHRGSGPECAVDGLRHT\n",
      "AWRTRVRGEHEIAVRLDGLRRIGRVKLEWGEGCPSRYRLEASADGANWTAVLERNGEEAN\n",
      "MRLNHLASDTSASGGAGAEELAFPTIEAAHVRLAAIRPAGTLGLELRRLSVYGPDAASAD\n",
      "VPAAEAGAGGGGVAASPREASDPRDASDSSDPADAPDSTDAASAAGAPKGGGRR\n",
      ">WJH29034.1_Paenibacillus_sp_CCCFT742_B\n",
      "MKSKSGYRTSRWGISLLITTMLTSFIPVSPQAYAAVQNQNQSQNENSTSHTITIDTSDVI\n",
      "QDDFLGVGVNTIPTALMPGQTQYGYTEAHWEVDKKRIQTIEPKVARVWFQIDWMEPTKGT\n",
      "YTWDSAKMKAFYKYLDAFKTAGTEVELNFGWKVGSTVHDWFPIPGIDPWTSAPADLDAYA\n",
      "VSASALLEELIHNRGYDNVKYLTFYNEPNGSWDFEAPGDQKAYYAEMVNKTSARLTADGL\n",
      "RDLIEIWGPEETGAPAWIEYMKEHADDAIDGYSFHVYGESYDGLGSAFAQRKEYVGDKPL\n",
      "HLTEFGWADDNASNWDAGYANSVIQTANMGVKSALMWQLNGVWTNDPTGGTNGTYTMWDA\n",
      "LPLGLNPRKTFYIAGMLNRYIPEHSKVLAVDTNGSTDVRAAAFRDNDGHYTVLVEAKAGT\n",
      "EKEITLDFGSTAVNNTIRKMVYKNDILQEPNAILPPVTATFPGGAMLTDSNVSDDYNVII\n",
      "YTTQPAETQVKLDNVNPTVRSGDSITLGAEVIDNIGSVTWSVVGQNNGTINSTSGVYQAP\n",
      "QVTDETLIAVRATSTADPSAYGVVLVRVLPSSLAGKVEVPTFSLDRHVFPSSEVLYLETA\n",
      "TSGAQIRYTTDGSEPTAQSSLYVRPIILNEGSLALYKAKAFKTGMQPSGTVSSLYQIGQI\n",
      "SSSPDGYKLCMVENGGDCYFQGKAVVAYGADGLFNYSIQEDGVACTSAILGDPIPGVNKR\n",
      "CYVNPEIPDELPVVTFFNAGFEKPATTSARPGPLTNGWVFDSRSGVQHNNGPFQAPAAPQ\n",
      "GVQTGYLKTDGGVSGTLSQSIHFKPGTYQMSFEAAKRTSFGGTQSFDVYFDDQVIGSYQP\n",
      "ESGSFETFRTDAFETTGGKHTIQFVATTTQGDNTAFIDDVRITLPLTPEDPYISNSSFES\n",
      "PVVTHPTGVLSGITADWSFNDQSGILRNGSSMTSMNAPTGLQAAFVRSQNGVQGSIHQSV\n",
      "TFPAGSYVLNLKAAAQTAEQPQPVQIQVGGQTVGTITPSSSTYQSFTTDWFTVADGSHTI\n",
      "TLTATGTGTHATFIDQITVEEVDVPDQAVLQNNGFEHPAITSQNGVAVGSGEAWSFKNNA\n",
      "GRIRNGSVFGASDAPEGTQAAYLQTLNGKQGEFSQSLIFPAGSYVIQFQAAKRTSFGGQQ\n",
      "SFDVYLDDQSIGSFTPGSGSYTAYTSNPFQITKPGKHQIRFVGTSGTGDNTAFIDDIVIT\n",
      "PNP\n",
      ">QNK55806.1_Paenibacillus_sp_PAMC21692_B\n",
      "MKSNRLPFMLVACVALLLASFIVFESADKVLANSTVNITLKNNTKAFEGTTLGMGGTVMP\n",
      "FGYHSSWKVKDFNDDDLAVLMTQFKKTGSTVARLWLDGAWWEPTNDNADPDVMLDSGFTW\n",
      "NSIEMNSLYKYLQAFKDMNVDVFVDVMVDDPRVMYPWLTAEYASNTGPNTGMIPEYAEHI\n",
      "AAMVKHLVVTKGFTNVKYVSFSGEPNNFFLTPPGVSKLTSYKDSMTAVRSRLQSENLLQY\n",
      "VKLIGPEIGYSDHDTASWLDDLSTNISASLDAYTIHSGQTKAEATDGSYVSLIKSFIDII\n",
      "KTNDPNGADKPIMITDYTPTGTIRRAEDGLNSVALIANGLRAGVSEFGRWSFADDIWTWP\n",
      "AGSNQTSTSFGDYGFGIIGSKQENFTPRPNYKATALAYKLIPKGSTAYQATTSNEAVIPA\n",
      "IIKTAEGKHTIIVVNWSNNDADVSFTLENAIHTTFKKYKFESASIDLVDKFGEIPASFGT\n",
      "KSISGTAFTDTIPANTIYYYSDIPDQTAPAQVAGLNVTAPDFHKANLSWTAGAEADLSYY\n",
      "RVYRSETSAFTPAQANKVGEIWIKPGGVPSFHDRAVEQGKTYYYKVSAVDSSENEGAASA\n",
      "YASVQVGAEAYSDTLSVIDSTDYDYYEIDSDFANGYKVRVYKKAGVIGFLQDKQGFSRQN\n",
      "LGLDFYSTPMVLKYNGSAFTDKVQNGGAESGSTAPDNWYTWNNANGSFTWDASVKHSGNR\n",
      "SLKITNANQSANSTWYQQTTDFIPGKHYEVSYWIKTDQVDGPNGAGRGAYLNIQFLDANG\n",
      "VSLGARGGADAYSNVGTQDWTYFVSDVTVPIGTATVQIGANFYENSGTVWFDDIRFEEQP\n",
      "DVSIVGQHGMFYEADSVTYSDISSTHKRIVTVVGDETLYYDFYTDRIEIKVQGPNAGGYL\n",
      "IEDGGIVPRNVTSAYWSDGSEDVMSDTFPGAFVTKNTTSLGLYQPPSSQMIRYEFGSAKS\n",
      "VTLKNGGRFRGYYPRFQINSNEVFTMKFPRKTDNPNGGAESGTTSPDHWTTWNQSSSGTF\n",
      "AWDSGTRHWGNKSLKITNATTDHSAWIAQMNAPGNLAKTLQLSAWIKTLSVAGTQGAFIS\n",
      "VEAKDSAHNVLATYRIPFVTGTNDWNKYQLSFNPPEGTAYLFIVGNLYSASGTAWFDDFE\n",
      "LSVADTGISNAGMEIGTGGPTGWSSWTSSGTPFAWDNSTYYKGKKSLKITNNANQYSAWL\n",
      "TSRSNLQVSKEYEFGGWIKTSNVSSGAMGAQLQAIAMDSNGKWLQADVSATVLHGTNDWT\n",
      "YVRGKITLPPLTASVQLQAQLWGVNGTAWFDDLFIRLVDKS\n",
      ">QNK57010.1_Paenibacillus_sp_PAMC21692_B\n",
      "MTKGEQMMDKGVKTVVKTICLLGLTAVLLLQTLLLSPTPLQANPAAHTVSIQPNVIVQDD\n",
      "FLGVGVNVIPVSFMEGTSQYGYQEAHWEMDKKRILALQPKVARVWFQIDWMEPTKGNYTW\n",
      "NSPKMLTFYKYMDALKEAGTEIEFNFGWKVGADIQSWFSIPGVDAKISAPADLDAYAAST\n",
      "SAVLNELINNRGYTNIKYLTFYNEPNGNWDFESPGDQQAYYATMVQKASDRLTADGLRDL\n",
      "VDIWGPEETVASWTQYMSANADAYFDAYSFHVYSQTYDGLSASIASRTNHAGGKPVMMTE\n",
      "FGFAQDDMSGWDGGLANSVIKAANEGVSAALVWQLNGVWLPDPYVGSDTNGNYALWDSLV\n",
      "VGTKPYKRYYETSLLTRYIPAHSSVVSVNTGSPDIRAAVFKTSGGDYTIVLETKEGTSKD\n",
      "VTFDFNGVNIGKTFYKHVYRDDVTLEGNAIIPAASASFAAGATFTDTGIDSEHNVVVYTT\n",
      "IPSQTQVEITPLEPMVTGGQSQQLSANVIDNTGGVTWSVIGSGNGSITGGGLYTAPQVAA\n",
      "ERLIAVKATSTNDPSSYGIALVKVRPAPSTGKVDIPTFSLAYGKYPSAEAVTITTTTPGA\n",
      "TIRYTTNGSTPTSSSAVYTGPIFLNPGMTRLKAVAFKTGLTSSAEAYNLYRIADASGGPD\n",
      "GYQFCAYENGFDCSFSGTASVAYGADGLFHYETLTNGTPCTNAVFGNPNPGAAKRCYFSF\n",
      "DIPAEPPVVTIYNAGFEKPGTSTYLTGPITNGWKFNVRSGVQRNGSALGAATAPEGVQTA\n",
      "FMISRDGLSGEMSQSLNFNAGTYNLSFQLAERTSYGGKLPFDVYVDNTKIGSFTPSTANF\n",
      "TTSTTDSFTVTAGYHTIKFVGAVTSSEASAFIDAVTIQLAEPTNPPAAELINDGFETPSV\n",
      "ASYLKGPMTHGWTFNSRAGVQKNGGAFGAAPAPEGVQTAFLQSVNGNHGEISQTASFAAG\n",
      "TYNISFKAAKRTNSGGTQSFDVFFDQTLIGSYMPTSGNFTAYTTDNFAASAGNHTITFIG\n",
      "TSSTGDNTSFIDEVKIQLVQPQNPPSLVIANDGFETPSVASYLKGPMTHGWTFNSRAGVQ\n",
      "KNGGAFGADPAPEGVQTAFLQSVNGDHGEISQIVDFEAGTYTLSFQAAKRTNSGGTQSFN\n",
      "VYFDQTLIGSYMPTSGSFSSYTTNSFAASAGYHTIKFVGTSVSGDNTAFIDSVAVQ\n",
      ">QNK57015.1_Paenibacillus_sp_PAMC21692_B\n",
      "MKIIKKYGMLLLAAAVMFQTLLFSPEPAAANASPESFTVDIDLQTIINDDFLGVGANIIP\n",
      "VSFMEGTNRFGYNEAHWEMDRKRILAMKPRVARVWFQTDWMELEKGVYQWDSDKMIEFYR\n",
      "YMDVLQEAGTEIEFNFGWKVGVEAQEWFSFPDVDKRISAPVDLDAFANAASAALNQLINV\n",
      "KGYDHIKYLTFYNEANGNWDFEAPGDQKAYFAQMVKKVSDKLTADGLRDLVDIWGPEESG\n",
      "APDWTQYMQENADEYFDAYTFHVYGQSYDGLTKSITDRTSVAGGKPVMMTEFGFAEDNSA\n",
      "WNAGLAGSVIKAANMGLGGALIWQLNGVWLPNPYVGNDTNGNYTMWDSLVLGTDPYRRYY\n",
      "ESSLLTRYIPPHSSVVAVDTGSEDIRAAVFKTDDGEMTIVLETKEGTNKEVAFDFNEAVN\n",
      "KSFNKHVYRADVSIDGNALIPGVSHTFAAGDSFADDEINAEHNVIVYTTMSAQTQVEVTP\n",
      "LESTVEGGETQTFDANVIDNSSGVTWSVIGEGNGTITNDGLYTAPSVTEEKLIALKATSI\n",
      "QDDEGYGIALVKVRPTAAEGQATIPAFSLPYGKYPSGEAVTITTATPDAEIRYTLDGSTP\n",
      "TLASELYTKPIFLLRGTTPLKAVAFKDGMNPSPVSFSLYKMANASLGPDGYQFCAYENGF\n",
      "DCEFTGEASVAFGSDGLFHYANLTDGAACTSALFGDPNPGTEKRCYFTYNIPAELPVVTV\n",
      "YNAGFEKPNVANYQTGPMTNGWYFNVRAGIQRNGGQFGAARAPEGGQTAFMVGRSFIGGE\n",
      "ISQKLHFKEGDYELWFSMASRSTPGGELPFDIYFDDTLIGSFEPNSSDFTLHKTDSFTAA\n",
      "AGYHTIKFVGAATETDHAVFLDGIKVRTAGMAPPPPDVQEPLPPEKPLETLGNAGFEEPQ\n",
      "VATHRAGPMKFSWNFNLLSGVQRNGGAFAAATAPEGIQTAFLQTKGGQFGEISQYLNFEE\n",
      "GRYKLEFSAAKRSTNGGRTQSFDVYFDDTIIGSYSLTSPDFESLSTISFNASEGPHTIKF\n",
      "VATHTSGQSETGESTGFIDEVSLRDVSGEPPDPEEPAEEPVALLEGPSEVHAGDTLDLKI\n",
      "GISKANEGYSAMDVIVHYDPAKLEFETIVDDDGHLILSSNAIQSLVGQLQVIGTGVKPEQ\n",
      "GQIRILMLGTGAPVSEDGHVIALQGKAKASASAGSTIITLSDFGISNESAAWQVDSHEAM\n",
      "LTVQVIEVDKSALNAEIVAAQALHDGATEGSHSGQYPVGSKNVLHAAILAAKAVNENSNA\n",
      "TKQQVMEAVSTLQQAVMMFRNSVHVAVPADKTALIAAIDNAQSKHDAAVDDGKLGHYAPG\n",
      "SKASLQTAIDAAKAVRESTSVTQTNVNDAVSGLNDAVQHFASQLVTLVEGNSRISIADLS\n",
      "IVAKYYGINSENASWNEIAIADLLDEGEITIRTLAAVARMILDDWLAE\n",
      ">WMJ22082.1_Paludicola_sp_MB14C6_B\n",
      "MKSKITARKEPIMARFCGAGFHNSEAGLYRKMSDRQFNEVVGKIYRELSPGFTRMWGGAP\n",
      "NWTKEEMDDFAEYCEKTHIPANTSIYLTGHTTRHQTQQEKEEYARNVADKLDYLINEKGI\n",
      "KNIEFYCMSNELSIEDWGNIFFELPVFKDYHTYLYREFKRRNLPVKLLATDASPYERWES\n",
      "IDWAISNGMVPISEIFGGHHYVNDFEPQDLDFYKVFYKNVKKTVKKLLPYERRFILGEFG\n",
      "LAQDMNNVNGVKMDVCKYFYDGQEAYSALMITEMALAAINAGVYACALWTFTDYPNPKGT\n",
      "DFRYNKWGLTKWDGDDYSPRDWLYCYGLIAKYFNKDSKPLTIETEDYYLRCGGVSNDDGS\n",
      "FSIAIVNRHEESTDITVSLKALSTNQPMRKYVYDSANVPRNKFGDMQSYTELISVTEDTA\n",
      "CIQVPANSVTLLTTDYINRTPCTVEDVSEDNGMIRWSKSTDPYFCYYRIYKGDSQNFVPS\n",
      "YDNQIASTIVESYRDESGVAGFYKVKVVDRFGNV\n",
      ">UVQ47681.1_Parabacteroides_faecis_B\n",
      "MRKKIFYFVVALIIYPYICIGQTIASMDSRATDVEHWISSHFAQGTVPPFSFEYGGKPSK\n",
      "EFIKDWAYSAKPLKSDDQHEVRYCYTYQDPASGLKVDCDVKGFTDSQAVEWVLHFTNTGS\n",
      "GNTPEIANVCVSDIVFRYDRPGNFRLHYANGSFPSKADFAPRLKELTSGENLYMRPDGGR\n",
      "SSHTAFPFFNIESPSGQGVMVAIGWTGTWFSDVRCTDVQSIQLKSGIERLKAYLYPKETI\n",
      "RTSSVCLLFWQGNDRMIGHNQFRRFILAHHTRKVDGKPAQYPFCKGFNYGDPTPCNEYTC\n",
      "LTADYAIALVKRYKQFKLLPEVFWLDAGWYDQSADVANNKNWANTVGNWTVDSVRFPEGL\n",
      "KPIADEIHKVGSKFMVWFEPERVYYGSAWAIEHPEYMLERPGADACLVNLGNPKACRWMS\n",
      "EYIGDFIEENNIDYYRQDFNIEPAGFWEANDEPGRQGICEIKYIEGLYAFWDYLLERFPN\n",
      "LLIDNCASGGRRLDLETTTRSAPLWRTDYSYGEPDGYQCHTYGLNFYLPLHGTGAWGVDK\n",
      "YTCRSSLSSAVTFNWKITEAGVSIYDMRDRQAEFEELRPYFLEDYYPLSGIDNTTAENTW\n",
      "LAYQLYRKSDDSGYIVAFRRKECPDKDCRVELFGVNPDKTYLLINKDTGDSIRKTGKELS\n",
      "EGLTLTLDEPRSSMIIRYQSDLSESVHDLVVGEKTDAVLQAIGAEFDPHFLSQNVTRNDG\n",
      "AKEKDWKNIIEKRIKDMDIHRFRVMVLPQWYEPENDNDDPDLINWDKFTFNSPEMQSLYR\n",
      "ELDLAQQQQMEVTLTLWGAPDKHFLAGRNSGDWVVAPESNEEWSENFSALIQYLIKEKKY\n",
      "TCIKEITPVNEPDWSFLVNGKRASTAKYIEMCKALDRRFKKDGIRELVDFSLSDNSDGGI\n",
      "GTHKYLAACTRELADVADVFNSHTYIFGYETPNSTILDWERQNYELSRSAGKPHFVGEFG\n",
      "GNQCVGAARQKDINLYERGVLMVRIAINLLNAGASGVSYWSLIDQYYGKNDSYEGMQQLG\n",
      "LWKYVKNAYAQDTCYENMTVDYEVRPQYFAYSLLTRFIRPGAEVYPISTPNEFYAGTAIK\n",
      "NKDGKWVYIFANGTAQEKKIKISNKHVGAKGTYEVYKYTQNALPKGDKQISPEKQVMKGG\n",
      "NEFFYTLPTNSVILLREK\n",
      ">BDD02170.1_Persicobacter_psychrovividus_B\n",
      "MNLLALMVAGGLAFGGCNNETDLPNPAANLSMNSKVVSTDFIGNGAQWGGYEMASKWLNG\n",
      "QESLSEADWATLFKRIDFMRPPFLRIMFNSGGIAPADYSSAKTKSLFKMLEYAQSRNIEV\n",
      "VFGEWGYAHKGADLLDVDQEWVSNSVQFLDYLIEKKGFSCIKTTNIINEPNGDWSAARSR\n",
      "YDVWLKVQQQYIQAMKKFPALQAVQLTGPDIAVFKDAAAKDWIQRASNDIGKNIGMYDIH\n",
      "AYVGQQFVKSGQYGQMLHEFKEATPAGKKLVLTELGFKYISQEDVDLKNENIKAIENDKF\n",
      "AGDDSNMMVYKPFYGVDMADAIIQGMRQGVSGTLVWSMDDAMYNSPKGNDYNTPELKKWG\n",
      "FWNILGEEHCNDAKDEAIRPFFYPVSLLCRYFPAGSTIYTLDLGAKKGLRAVMAEKDGKY\n",
      "TIAMVNGHYATYELNLLNKKLGGQDMDVYRYQAKFDGSDTFDAPTDKDGFAVPTETNRHF\n",
      "QFNENTPFEIKGQSVVLLTNMK\n",
      ">BDD02164.1_Persicobacter_psychrovividus_B\n",
      "MLNKYFFGAGLLLALQACNQAPQHPTVTVHKEQVVCNQYIGNGVEWDAYPHADSKSAEWG\n",
      "DLMNNPAKWDTLYARLDRMQPQFIRMMDQANWRYYMGLNRHKKAVLNFNTPEIKTLFKLL\n",
      "DYCQSRNITVVMGEWGTPHHMHDIENKKDKLKAADDPRWSKMIAQYLDFLINKKGYSCIK\n",
      "YYNLVNEPNGDWASTLGDFDLWKRGVKQLHKELKAKGLDDKIQISGPGTVPQYSYPKYKS\n",
      "QYEGKDWVKMSVDSLNDELGAYEIHAYMPTMIVREGKAAKDVFWKEAIAQTHKTGKPFLI\n",
      "GELGLKDNFGPFHEKNIARAKKDAFTSPEDSQMAIYDYQYGVDMADAVVQFMNAGCAGTI\n",
      "AWALDDAMHTMGDKGDKTKLKRWGFWNILGTEIENSPKDEQIRPWFYPWSWACKYFPAHT\n",
      "EILKVDVPAIKGLRITAGTKEDKYSVMAVNNSEEIQTVTVQIDGLKSSPQLKKLTYTREQ\n",
      "ATAEKAKISTEQVSVSAQGGLSVTLPAKSVVVMTNMNK\n",
      ">AGB28643.1_Prevotella_dentalis_DSM_3688_B\n",
      "MIMMKRFYIGLIIFLSATPIFAQTQIVVRQKSGGMKAIPITSISNITFGEERLKSIDLGL\n",
      "PSGTLWSNCNLGSTYPEEYGDFFAWGEPIQKASFTQQNYLYYSNGTYTAIGNNISSTSHD\n",
      "AATENLGGQWAIPTIQQLQELIDHCTWTWNSYNNIPGYTVTGTNGNCIFLPANGNYYDGT\n",
      "THDNIGTCGFYWSANSGTQARNARFLGFKKGEYTIQENTRDLGFCIRPVTHQPENQPLQL\n",
      "SVGNPTGVSLQGIGVEFDPHFLTACLAKNDGAKTEDWDNVIVPRVKQMKPHNFRVWVMSQ\n",
      "WFEPTNDNDDPYTIDWNTLNFNTKEMRALCKELDLAQEINAEVTIVFWGASVGSWMAGGQ\n",
      "TGNWLFVPKDYDEWAENCAILAKYLIDTKHYTCVKMLTPINEPNFYYGHFQYMTAANYSI\n",
      "ICHKIADQLDRLGIKDKISLNLSDNIHDDIDFLAKACENVKDVAGMFNSHCYRFGYESSN\n",
      "EEIGAWEKRNVDLAKAAGKMHFVGEFGSNRTMLSARQADIDYYRRGILIDRLVLNFLNYG\n",
      "ACGCSYWQLFDEWYSAHDSYASMQQLGMWRYVKDVYRNEPYYYKLKYDYQPRPQYYAYGL\n",
      "LTQHTRPGADIHPISINQGKMAATAFRNVDGRWVYVFANPDNTSYTIDLTNKYHNQSNKF\n",
      "SVFRYMADELPYDDKLLAPVDEVEAGNHLYCKIPATSVVLIKEK\n",
      ">AGB28629.1_Prevotella_dentalis_DSM_3688_B\n",
      "MKTIRLYRFLACCFCLVMPFLLKAQTAIDFRGERMDVGRWAATHFARHGEHPFSFTYGGR\n",
      "ASATFLKGWSYTVSRRMSPLSDVTNTVYTYTAPDRSLRVDCDVKLYRRQQAVMWTLRFTN\n",
      "IGQRPSQPIAQVKTTDLSLQNRGRQPFTVHYAKGSNADPDDFAPRQTVLSGDAGLSLRPV\n",
      "GGRSSQGNFPFFNLDTGRGQGVIAAIGWTGTWMADFRSTAPGCMSMVTGIERLNTWLKPG\n",
      "ESIRSSSACLLFWQGENHVDGQNQWRRFVLSCLTPRVDGRPVCYPLTTSFNYGDPYPCNE\n",
      "YTCLDEDYAIALVQRYKQFNLAPKVFWLDAGWYAESARVKEGCNWYNTVGNWTVDRDRFP\n",
      "NGLKPVSDAVHAIGSELMVWFEPERIFKGSQWSKELPKAWLIDGGPQTESYLFNLCDTAA\n",
      "VAWLSRYINRFMDENGIDHYRQDYNIEPAGFWAANDEPGREGVTENHYVEGLYAYWDNIL\n",
      "KHHPHGFIDNCAGGGRRLDLETIQRSAPLWRTDYRYGEPVGYQTHTFGLALWLPQTGTGV\n",
      "MGSDKFSSRSSLSTTVVYDWKITEPEFNLTEVRQLMDEYEELRPYYFEDYYPLTGTDRVL\n",
      "GDSIWLAYELNRPSGQDGVVVAFRRASVPDSSCTVRLRGLDPRLTYTLTDRDSRRSFTQT\n",
      "GAQLARGLRLVLPQPRSSLILTYTANPAARPAQLAVADPNPQKVVGMGVEFDPHFLSQNV\n",
      "TRSEGCRAEDWDSVICRRVAEMQVQRFRVMVLPSWYEPQNDDADAHHIRAAGFTWESREM\n",
      "QSLYAELDLAQRLGIQVNLTVWGAERNHFLAQGNDGDWVVAPTNLEEWAENISALVQHLL\n",
      "HDRHYSCIREITPVNEPDWAFIHNGRKSTPDPYIRMCRVLDARFRQDGIRDKVDFCLADN\n",
      "SDGGMGTHKYLQACTRGLADVADGFNSHTYIFGYDTPNSVIYHWEWENCQLAGRAGKPHF\n",
      "VGEFGGNQCVGSTRQRDINLYERGVLLARIAINCLQAGASGLSYWSLLDQYYGRQSDYNA\n",
      "MQQLGLWKSVWRAYAGDSLYQGLHTDYEVRPQYYAYSLLTRFVRSGAEVYPIPTNDEFYA\n",
      "GMALKNTDGRWTYVFANAHATPRHIRLSNRRAPKGTFEVYRYVQQELPTDGRQIQAAAQR\n",
      "LRGQTELDYVLPASSVVVFYQTTF\n",
      ">QMW75430.1_Thomasclavelia_ramosa_DSM_1402_B\n",
      "MVHRVKQVSIVVLSMLVLLSTLIVGTYAKATNLVSNGDFSQGTNYWSMNQSDGSLAMMSS\n",
      "DNHSLKVQIEKVNSDDYWWSLTLKQDNIALSANKKYQLSFDVEASMSGDISLDIESTSDY\n",
      "NKKYLDRQMIAISNQKKTYTFDFEKKDDDAVTLVYHLAKGDGISDFSNQIIKLSNVTIIE\n",
      "IGDIEIQKAGDWYLNEGDGANGKLSGEPNDLKVKVTSINQENYWWALSLKKENLVLSGNK\n",
      "IYKIVFDAKASKAGTIGIDIEKSADYNVKYLDKQNFDLTTTSKEYSFNFIKKDNDDVSIV\n",
      "FLLNEGDGISNFKDETINIRNVRIEEVNDLGDEYVVNGDFETNTTSGWNTYNSNGSNLKI\n",
      "NAVNQQLEVTFPNSNGSNYWDCQLFQGDILLDNGIYRLSYDLKGSKAGTIYFDVEDTGDY\n",
      "ATKYYPETMVDFTKDVQTYNFEFEINADNLLGTQKNAKIQFNLGPNEHCDSLAGETLYFD\n",
      "NIKIEKIGSGAGTGELQTTNVTFDGNDVLVNNFKGLGVQWDPYVVHPLTDEEWQTVTKRV\n",
      "DFLNPAFVRCMIYANTYCEGFDDEGNPIYDFDSLANQALIRELDYLESRDIEVVLGEWET\n",
      "PGRFGGEFEGITVDDPRWASIIGGFLDYLINQKGYTCIKYFNYVNEANSDWSYCGDFDKW\n",
      "QTGINYLHTELDKYGLNEKIKITGPDTVWDSDNTWLKEINSNQDLGAKIGLYDTHMYPTI\n",
      "DEITNGTIEEMVAEQRSCVTGKDFYMTEIGMVTGKSDGDSQPYTKEFSYGVIMADAASQV\n",
      "MRGGFSGLAIWDLDDAMHDQQNGFPITDIRSLKQWGFWNSVAGRVFNQPEEEEIRPFFYT\n",
      "WSLMANLFPRNSKIIGSTANKELNGLRTVGMEKDGQMTYMIVNDSNSPKEVTIDVKNLNA\n",
      "NNLKLFKYDYFDNDRKVDSNGYPVASKVLENVNLEEGYEVSLPSGGVVMLSTIDIEDAKK\n",
      "ELVDQNDSKQDNENKNEVAIKTGDDLKAAGFMISGLLATAFIYGMKKKG\n",
      ">QQV06122.1_Thomasclavelia_ramosa_B\n",
      "MREKYKGERNIMNRKFKRFLTSLLSLAVVASSGIGPVKAVDNTPKLDSKVYINSDNVLTK\n",
      "DFEGFGVQWDPSDLFDYTDEQWSSFYEKASFLSPNVMRVMLHDGDSYCIGFEDDGTPIYD\n",
      "WESVMMKRVYKILDFAQQNDIPIMLGEWRSISERGYLSYDDHGKTVNWSSPTWARMIGDC\n",
      "LEHLIVDKGYTCIKYYNMINEPNYYKRDHGDVTNEYVYDQWKQAITNLRNEMDSSGIEKI\n",
      "ENIKIVGPDVYDSQEAWINQATSDEMKDKIELTEVHRYAPQSEVESGLIEKKLKTWKEQA\n",
      "ESLDPEVAEEGFALGEMGISGTGPGDSQLNARKYDYGVDIFDYGVQAIRAGLKFGSVWGF\n",
      "EDSMHVQHNDIVNNFKDQYGPAATTEEGRDYVVHTPTGDPSIDNDIKIWGFWNELGEEMA\n",
      "AQNAEHNVTGRANTVKASDENLKPWYYTWSMLCRYFPSGTKILETTDSYVDQLRVTSGII\n",
      "PVADDKGDISIAVVNNSSSQKTLEVNMPNAASKVDLNQYFYYDGEIDGKTRPVNEKGQLL\n",
      "QYDTIENANLKDGVNVTLPAKSCMILTSLGYEGESHPMSFTTGQTTDVEKVEIYETTNAN\n",
      "QLEVGKSYQLAANYIPSISKGEMEWSVVDYFGNASDKALIDENGLLTVKKAGQFKVIGNL\n",
      "KGKPEIQDTLVFKATSSSILVDELNDLENGVALSYQDIIKDDNSANFNGDKTVKRSDSNA\n",
      "NGKPGIITYQANNIYDFEFSAYSLNNNLDKSGNFVVEVSQNGDSWSPVECEFIQGSKLSS\n",
      "GWYPYTIKNKAEIKDDGYQYLRVTITSKSGYKTYDPQYAGGSIYYDYQGASQIDIQSHNE\n",
      "FIVKGQELQFKAEVLPSIASQEVSWKVLSLEGKPTELATISPDGILTAKAKGEVVVVATA\n",
      "KDTDVSAYSHINIINGYFVDEIEDFSKMYQYGEFAFDDPKSSNFTDKTRIKRLSDSNQSI\n",
      "VYALSDIEKATFEIYKNGSFVNDSVDIYASSDGLTYNKVEKNVVNAGKAASSTEYYLYEV\n",
      "STKELGDNVNYIKLELKNDEIIYCPMLGKTKIIYNPIENVEVTNVTLDQKELSINVGQSK\n",
      "TLVKKLAPLYADEQLTWSSRDEDIASVDQNGIVTAKKVGSTIIYAKYNDEIYATSVINVL\n",
      "GENMALNKDVSASTETNQWNKNPTGKLVNDGDYDTRWVSKDGTSITKEQITIDLGEVTTV\n",
      "DNVKLYWESARATDFNIEVSTDGSKYDIVEKLRDEDKNKLTNEISFDPVEARYVRMQGLT\n",
      "PATKYGYSIYEFEIYNNSDLKLASSVEFKEMSSELYLGENTALDVVVTPDDATYQDASYT\n",
      "SSNEFVVVCKNNQMIAVGEGTATITANVNGQKITKEITVVKDNARKIAQELTSLTVENGR\n",
      "VDFPTVDGYSFSVFSSDLEKVIAKDGSVNLPVEDQEVALVVTVSKDGSEDSANTDEIKVM\n",
      "VKGSRDKYELLEKRIKEIEETDWTVYKPGTVKTFKEKLQAVKESLNAGVLLVSEVEKAGE\n",
      "NLEAAFKGLEIKSDKKTLDALIKELEELDTKVYTEVSVARVEKALEKAETVSENEDASEA\n",
      "EVNDAVQALYEAKLGLVEQINYDNLKDRIEEIEKEDLSIYSEATAARLKEQIAEAKEALK\n",
      "NENITNEELQEELAGLNEKYSSLKLNHEPGSVEELIKRIEEMDLSGYSEASVKELERVIK\n",
      "EIKEELLEGVDQVRYAKLAEKLQTAYEGLERKSEVKPVEPEQLETPKGDEQAAKTGDNMI\n",
      "IGTWLITMSAAVMVVIFLNKRRSLEK\n",
      ">ADB80105.1_uncultured_microorganism_U\n",
      "MKTCPLLLLSAFSLAWLATACEKRIELTITDEVINAHYLGNGVEWDPYDEAISWGCPLSE\n",
      "TEWDTLYARLDYMQPQYVRCMINSPFTYFTGEGFEDGRNAENLLKLLSYCQSRDVMVVYG\n",
      "EYNPPTWEMKGSQEWVEASVKHLNWLVADQGFDCIKHFVIFNEPDGNWASTDGDFGFWRE\n",
      "MVRRFQAEMDKYPVLKEKVSIAGPDAVIDYRNPASPYDAAGWLKATVEGVPEIGIYDMHA\n",
      "YPGQRYVRSGEFEETLKGLKALVDKPIILGEAGFKYFSDPADSALAQEYWKRVEGHPFTK\n",
      "GSDCNMLVYDSFYALDMPLLLMSVMNAGFSGAAAWMLDDAMHSNGDSGKTEDVKLWGMWN\n",
      "ILGDKVFGDASQEEVRPWYYTWSLMCRHFPAGSRILRLQGLPEGMAAAVAQKPDGTYAVA\n",
      "LVNFGDQAQEVRLQLPETCDGYSVQYYTDHLEKQSVPASRKPALTIPAQAFAIFAIE\n",
      ">CAZ94303.1_Zobellia_galactanivorans_B\n",
      "MKKMILYNLFLLLILACSSESSTDTPPADKDLSTEKPGETLLIKNQNPLSVDFVGNGAQW\n",
      "GGYELIENFTGVDDFNEADWNTLKERIDFMRPSFMRIMVSSGWNYTDTDGAFQPEKGNNA\n",
      "FHRMMQYCTDNQITVMFGEWGHSYLNDDRNQVDETWLDNAVNYLDYLIDTKGYSCIKYYN\n",
      "MVNEPNGDWSSTNTDYELWQKVASGFQSRLESKGLHQSVKLAGPDIAVFGDAGAVSWITR\n",
      "SKSKFNEKLGLYDIHAYPTKSFVTEGGYLEMLKAYKGAIPEGEQIVLGEIGIKFYGADAD\n",
      "LQTENLKRINADPYASDDSNMSVYDGTYAIDISDAMVQSMMAGFSGALVWDVDDAMYNKS\n",
      "GSGSGPDAKKLKRWGFWNILGEEAFGGASDEEIRPFFYPVSLLCRYFPKGADIYEVQLPN\n",
      "KKGLRAIAAKKGDTYTLAIVNSNFVAYDDLSIKAEDNFSFDGVSQYVCTSMPDGSFQAKV\n",
      "DANGFALPLEQDISIPLDGKHKVNIPARSVIVLTNMP\n",
      ">CBK67650.1_Bacteroides_xylanisolvens_XB1A_B\n",
      "MKKRILYYLFILLLFPHNGTGQTVARMSDRPVNTSQWITTHFARGVVPPFSFEYGGKPSQEFIKSWSYTATRQKSDDPKVLKYLYTYREPSGGLKVECEVKGFTDFNTVEWVLRFTNQGKKNTPEIANIKVSDITFRYQHPGAFNLHHSEGSHASKSDFSQQLTILSPGDNLYMRPEGGRSSQMRMPFFNIESPANQGVIVAIGWTGTWFADVRCADQQSVALTSGIERLKTYLYPEESIRTSSVCLSFWNGSDRMKGHNQFRRFVQAHHTWKVGGKPTVYPISTSFNYGDPTPCNEYTCLTTDYAIAMVKRYEQFKLVPEVFWLDAGWYNHSADVANHKNWANTVGNWTVDSIRFPEGLRPIADEVHRVGSKFMVWFEPERVMKGSAWALQHPQWMLDARGKAKQEDWTKDGEHDSYLFNLGNPEACRWMSKYIGDFLEENGIDYYRQDFNIEPEGFWAANDEPGRQGICEIRYIEGLYSFWEYLLNRFPGLLVDNCASGGRRIDLESISRSAPMWRTDYSYGEPIGYQCHTYGLNLYLPLHGTGTVSADKFTFRSSLGTSIIYNWKITEAGQSIYDMRDRQAEFKELRPYFYEDYYPLSGINNITSENIWLAYQLYRPSDDSGYIVAFRRKDNPDKSYTVNLSGLHPDHTYILTNKDTGEAIKKTGKELANGFTLTLDNPQSSLIIKYQSSTTAIQKLSVGKKTGVKLRAIGAELDPHFLSQNVTRNDGAKAEDWDRIVVKRVKEMGLQSLRVMVMPQWYEPKNDNPDASKIDWHNFTFNSVEMQSLYKVLDMAQEQKMEVTLVLWGAPPGHFLTEGNYGNWVVAPTNYEEWSENFSALVQHLLNNKKYTCVKEITPINEPDWSYIIKGKAAPTADYIEMCKVLDRRFKEDGIRNKVHFSLSDNSDGGTGTHKYLAACTKGLANVADVFNSHTYIFGYETPNSTILDWEKQNSQLASSVGKAHFIGEFGGNQCVGATRQKDIDLYERGVLMTRIAINLLNAGASGVSYWSLIDQYYGKDADYGAMQQLGLWKYVKKTYASEPYYNDIKSDYEVRPQYYAYSLLTRFIRPGAEIYPIATPEEWYAGTAVRNTNGKWVYVFANGMDQEKAISLINQHTQTKGNYQVYRYIKDGLPTTDQMLAPDAQPLKVNDKILCLLPAHSVIVLKQE\n",
      "\n",
      "Number of sequences of the outputfile after including characterized sequences: 69\n",
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "#following code checks if the ID's of characterized enzymes are present in the FASTA sequences file. If so it removes the ID and sequence\n",
    "#afterwards all ID's and sequences of characterized enzymes are added at the end of the file\n",
    "\n",
    "if go == True:\n",
    "\n",
    "\n",
    "    print('Creating a file containing clustered sequences and all characterized sequences with corresponding CAZy description')\n",
    "    verified_IDs = blastchar[2]\n",
    "\n",
    "    #create a list of sequences from characterized proteins that were verified to have domain results\n",
    "    characterizedsequences = []\n",
    "    for seq_record in SeqIO.parse(os.path.join(jobname, f\"Characterized_{family}_{taxsubset}_FASTA_sequences.fasta\"), 'fasta'):\n",
    "        characterizedsequences.append(str(seq_record.seq))\n",
    "\n",
    "    with open(outputfile,'w') as f:\n",
    "        for seq in SeqIO.parse(inputfile,'fasta'):\n",
    "\n",
    "            if seq.id.find('_') >2: \n",
    "                proteinidentifier = seq.id.split('_')[0]\n",
    "            elif seq.id.find('_') != -1:\n",
    "                proteinidentifier = seq.id.split('_')[0]+'_'+seq.id.split('_')[1]\n",
    "            else:\n",
    "                #print(seq.id.split('_'))\n",
    "                proteinidentifier = seq.id.split('_')[0]\n",
    "\n",
    "            #if by chance a protein has the same ID or sequence as a characterized enzyme, the protein won't be included this time\n",
    "            if proteinidentifier not in verified_IDs: \n",
    "                SeqIO.write(seq,f,\"fasta\")\n",
    "\n",
    "        charoutput = ''\n",
    "\n",
    "        #Lets make sure to only add unique sequences (so no duplicate characterized proteins)\n",
    "        charsequences = []\n",
    "\n",
    "        #Let's add the characterized enzymes. Take into account the chosen taxonomy subset\n",
    "        with open (os.path.join(jobname, f\"Characterized_{family}_{taxsubset}_FASTA_sequences.fasta\"),'r') as r:\n",
    "\n",
    "\n",
    "            for seq_record in SeqIO.parse(r, 'fasta'):\n",
    "\n",
    "                #extract the protein ID from the header\n",
    "                if seq_record.id.find('_') >2: \n",
    "                    proteinidentifier = seq_record.id.split('_')[0]\n",
    "\n",
    "                #if there is an '_' in the identifier, we need to combine the two parts after splitting them    \n",
    "                else:\n",
    "                    proteinidentifier = seq_record.id.split('_')[0]+'_'+seq_record.id.split('_')[1]\n",
    "\n",
    "                if proteinidentifier in verified_IDs and seq_record.id[-1] == taxsubsetvalue if taxsubsetvalue != 'All' else proteinidentifier in verified_IDs:\n",
    "                    #ID's like AW_12345 will be converted to AW12345\n",
    "                    if proteinidentifier.find('_') != -1:\n",
    "                        protid = proteinidentifier.replace('_', '')\n",
    "\n",
    "                    #all other IDs remain the same\n",
    "                    else:\n",
    "                        protid = proteinidentifier\n",
    "\n",
    "                    #we need to add the description again\n",
    "                    if seq_record.id.find('_') >2: \n",
    "                        desc = \"_\".join(seq_record.id.split(\"_\", 1)[1:])\n",
    "\n",
    "                    else:\n",
    "                        desc = \"_\".join(seq_record.id.split(\"_\", 2)[2:])\n",
    "\n",
    "                    #for the characterised ID's we did a succesful BLAST search for:\n",
    "                    if proteinidentifier in blastchar[0] and str(seq_record.seq) not in charsequences: #only unique sequences!\n",
    "\n",
    "                        charoutput += '>' + protid+ '_' + desc + '\\n' + blastchar[1][blastchar[0][proteinidentifier]]+ '\\n'\n",
    "\n",
    "                    #for all other characterised ID's\n",
    "                    elif str(seq_record.seq) not in charsequences: #only unique sequences!\n",
    "\n",
    "                        charoutput += '>' + protid + '_' + desc + '\\n' + seq_record.seq + '\\n'\n",
    "\n",
    "                #add the sequence to the list\n",
    "                charsequences.append(str(seq_record.seq))\n",
    "\n",
    "        print('Writing '+ outputfile + '\\n' )\n",
    "        f.write(str(charoutput))\n",
    "\n",
    "    with open(outputfile,'r') as f:\n",
    "        print(f.read())\n",
    "\n",
    "\n",
    "    print(f\"Number of sequences of the outputfile after including characterized sequences: {sizefastafile(outputfile)}\") \n",
    "    print('Finished!')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "38869ed8",
   "metadata": {},
   "source": [
    "# Domain detection: InterPro"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 62,
   "id": "3d537fc1",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import necessary modules\n",
    "import urllib\n",
    "from urllib import request\n",
    "from urllib.error import HTTPError\n",
    "from urllib.error import URLError\n",
    "from time import sleep\n",
    "import json\n",
    "import sys, errno, re, json, ssl"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 66,
   "id": "8f0d454a",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ATO84721.1': {'[5, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 26]': 'SIGNAL_PEPTIDE', '[19, 26]': 'SIGNAL_PEPTIDE_C_REGION', '[27, 620]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 18]': 'SignalP-noTM', '[333, 503]': 'G3DSA:3.20.20.80', '[358, 495]': 'SSF51445'}, 'BBL06275.1': {'[86, 340]': 'G3DSA:3.20.20.80', '[4, 240]': 'SSF51445'}, 'BBL01040.1': {'[15, 251]': 'PF00150', '[22, 352]': 'G3DSA:3.20.20.80', '[30, 348]': 'SSF51445'}, 'UWN65549.1': {'[1, 25]': 'SIGNAL_PEPTIDE', '[26, 526]': 'NON_CYTOPLASMIC_DOMAIN', '[125, 430]': 'SSF51445', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[189, 523]': 'PTHR42767', '[97, 430]': 'G3DSA:3.20.20.80', '[1, 20]': 'PS51257', '[26, 45]': 'mobidb-lite', '[9, 20]': 'SIGNAL_PEPTIDE_H_REGION', '[21, 25]': 'SIGNAL_PEPTIDE_C_REGION'}, 'CBK63196.1': {'[1, 20]': 'SIGNAL_PEPTIDE', '[59, 384]': 'G3DSA:3.20.20.80', '[7, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[21, 493]': 'NON_CYTOPLASMIC_DOMAIN', '[47, 381]': 'SSF51445', '[17, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 21]': 'SignalP-noTM', '[1, 19]': 'PS51257', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'UZO80939.1': {'[24, 506]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 30]': 'SignalP-TM', '[19, 23]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 23]': 'SignalP-noTM', '[45, 306]': 'G3DSA:3.20.20.80', '[10, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[75, 373]': 'SSF51445', '[53, 300]': 'PF00150', '[1, 22]': 'PS51257'}, 'UZO80937.1': {'[5, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[21, 521]': 'NON_CYTOPLASMIC_DOMAIN', '[89, 353]': 'G3DSA:3.20.20.80', '[70, 314]': 'SSF51445', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 20]': 'SIGNAL_PEPTIDE', '[17, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 24]': 'SignalP-TM', '[74, 317]': 'PF00150'}, 'AGY53053.1': {'[1, 22]': 'SIGNAL_PEPTIDE', '[5, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[31, 377]': 'G3DSA:3.20.20.80', '[1, 24]': 'SignalP-TM', '[5, 27]': 'TMhelix', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[23, 489]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 18]': 'PS51257', '[17, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[57, 284]': 'SSF51445'}, 'ANU59401.1': {'[181, 436]': 'SSF51445', '[27, 533]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 26]': 'SIGNAL_PEPTIDE', '[65, 434]': 'G3DSA:3.20.20.80', '[22, 26]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 24]': 'SignalP-TM', '[1, 25]': 'PS51257', '[11, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[188, 531]': 'PTHR42767'}, 'ANU59398.1': {'[50, 256]': 'G3DSA:2.70.98.60', '[308, 626]': 'SSF51445', '[318, 333]': 'PR00743', '[791, 1129]': 'PTHR42767', '[314, 521]': 'PF02065', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[722, 1071]': 'G3DSA:3.20.20.80', '[321, 586]': 'cd14791', '[22, 1169]': 'NON_CYTOPLASMIC_DOMAIN', '[291, 591]': 'G3DSA:3.20.20.70', '[1, 21]': 'SignalP-noTM', '[492, 508]': 'PR00743', '[374, 396]': 'PR00743', '[743, 1073]': 'SSF51445', '[16, 21]': 'SIGNAL_PEPTIDE_C_REGION'}, 'UBD71149.1': {'[1, 19]': 'SignalP-noTM', '[18, 485]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[4, 12]': 'SIGNAL_PEPTIDE_H_REGION', '[39, 360]': 'SSF51445', '[1, 17]': 'SIGNAL_PEPTIDE', '[16, 351]': 'G3DSA:3.20.20.80', '[13, 17]': 'SIGNAL_PEPTIDE_C_REGION'}, 'QUT88730.1': {'[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 20]': 'SIGNAL_PEPTIDE', '[21, 493]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 22]': 'SignalP-TM', '[57, 390]': 'G3DSA:3.20.20.80', '[1, 18]': 'PS51257', '[6, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[67, 349]': 'SSF51445'}, 'UWN88717.1': {'[1, 19]': 'SignalP-noTM', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[16, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[79, 362]': 'SSF51445', '[40, 302]': 'G3DSA:3.20.20.80', '[1, 21]': 'PS51257', '[20, 471]': 'NON_CYTOPLASMIC_DOMAIN'}, 'UVR10658.1': {'[161, 461]': 'G3DSA:3.20.20.70', '[178, 496]': 'SSF51445', '[930, 1037]': 'G3DSA:2.60.40.1180', '[184, 391]': 'PF02065', '[244, 266]': 'PR00743', '[661, 999]': 'PTHR42767', '[362, 378]': 'PR00743', '[582, 907]': 'G3DSA:3.20.20.80', '[2, 126]': 'G3DSA:2.70.98.60', '[613, 943]': 'SSF51445', '[188, 203]': 'PR00743', '[191, 456]': 'cd14791'}, 'UVO70767.1': {'[19, 289]': 'G3DSA:3.20.20.80', '[36, 291]': 'SSF51445', '[43, 386]': 'PTHR42767'}, 'UVO70768.1': {'[1, 24]': 'SIGNAL_PEPTIDE', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 22]': 'SignalP-noTM', '[25, 144]': 'NON_CYTOPLASMIC_DOMAIN', '[9, 19]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'PS51257', '[20, 24]': 'SIGNAL_PEPTIDE_C_REGION'}, 'QGT72561.1': {'[5, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 21]': 'SignalP-noTM', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[41, 375]': 'SSF51445', '[37, 346]': 'G3DSA:3.20.20.80', '[22, 487]': 'NON_CYTOPLASMIC_DOMAIN', '[17, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 16]': 'PS51257'}, 'UWO00929.1': {'[42, 278]': 'PF00150', '[1, 2]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 22]': 'SIGNAL_PEPTIDE', '[36, 352]': 'G3DSA:3.20.20.80', '[1, 23]': 'SignalP-noTM', '[15, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[43, 379]': 'SSF51445', '[23, 490]': 'NON_CYTOPLASMIC_DOMAIN', '[3, 14]': 'SIGNAL_PEPTIDE_H_REGION'}, 'UWO00930.1': {'[46, 372]': 'G3DSA:3.20.20.80', '[1, 18]': 'PS51257', '[20, 505]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 19]': 'SIGNAL_PEPTIDE', '[16, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION', '[74, 364]': 'SSF51445'}, 'UVR93289.1': {'[19, 23]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'SignalP-noTM', '[58, 366]': 'SSF51445', '[24, 377]': 'G3DSA:3.20.20.80', '[1, 21]': 'PS51257', '[24, 497]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'QZU84679.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[20, 509]': 'NON_CYTOPLASMIC_DOMAIN', '[16, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[21, 374]': 'G3DSA:3.20.20.80', '[1, 19]': 'SIGNAL_PEPTIDE', '[61, 301]': 'SSF51445', '[4, 15]': 'SIGNAL_PEPTIDE_H_REGION'}, 'CBK67267.1': {'[19, 23]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'SignalP-noTM', '[1, 20]': 'PS51257', '[24, 495]': 'NON_CYTOPLASMIC_DOMAIN', '[44, 288]': 'SSF51445', '[22, 378]': 'G3DSA:3.20.20.80', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'QEG33916.1': {'[27, 330]': 'G3DSA:3.20.20.80', '[44, 315]': 'SSF51445'}, 'ABP68096.1': {'[499, 627]': 'G3DSA:2.60.120.260', '[11, 23]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[75, 307]': 'PF00150', '[1, 28]': 'SignalP-TM', '[24, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 29]': 'TMhelix', '[391, 574]': 'PTHR45713', '[15, 378]': 'SSF51445', '[511, 623]': 'PF00754', '[29, 628]': 'NON_CYTOPLASMIC_DOMAIN', '[57, 347]': 'G3DSA:3.20.20.80', '[377, 492]': 'G3DSA:2.60.40.1180', '[493, 628]': 'PS50022', '[501, 627]': 'SSF49785'}, 'BDI31947.1': {'[1, 27]': 'SignalP-TM', '[23, 30]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 30]': 'SIGNAL_PEPTIDE', '[67, 342]': 'SSF51445', '[11, 22]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[97, 390]': 'G3DSA:3.20.20.80', '[31, 507]': 'NON_CYTOPLASMIC_DOMAIN'}, 'ADV49313.1': {'[6, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[401, 512]': 'G3DSA:2.60.40.1180', '[22, 514]': 'NON_CYTOPLASMIC_DOMAIN', '[70, 382]': 'SSF51445', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 21]': 'SignalP-noTM', '[28, 393]': 'G3DSA:3.20.20.80', '[17, 21]': 'SIGNAL_PEPTIDE_C_REGION'}, 'ADV49311.1': {'[6, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 20]': 'SIGNAL_PEPTIDE', '[21, 505]': 'NON_CYTOPLASMIC_DOMAIN', '[54, 291]': 'SSF51445', '[17, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[47, 365]': 'G3DSA:3.20.20.80'}, 'APU67655.1': {'[45, 382]': 'G3DSA:3.20.20.80', '[7, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[19, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 22]': 'SIGNAL_PEPTIDE', '[69, 291]': 'PF00150', '[23, 516]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 20]': 'PS51257', '[1, 26]': 'SignalP-noTM', '[74, 385]': 'SSF51445', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'APU67659.1': {'[50, 364]': 'SSF51445', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[7, 29]': 'TMhelix', '[10, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 28]': 'SIGNAL_PEPTIDE', '[29, 494]': 'NON_CYTOPLASMIC_DOMAIN', '[22, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[22, 375]': 'G3DSA:3.20.20.80'}, 'WLC65246.1': {'[506, 528]': 'TMhelix', '[51, 387]': 'SSF51445', '[12, 34]': 'TMhelix', '[1, 11]': 'CYTOPLASMIC_DOMAIN', '[506, 527]': 'TRANSMEMBRANE', '[33, 505]': 'NON_CYTOPLASMIC_DOMAIN', '[314, 336]': 'TMhelix', '[528, 530]': 'CYTOPLASMIC_DOMAIN', '[12, 32]': 'TRANSMEMBRANE', '[60, 386]': 'G3DSA:3.20.20.80'}, 'QTH43817.1': {'[64, 343]': 'G3DSA:3.20.20.80', '[995, 1145]': 'G3DSA:2.60.120.260', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 27]': 'SIGNAL_PEPTIDE', '[506, 605]': 'SSF49265', '[683, 838]': 'SSF49785', '[28, 1300]': 'NON_CYTOPLASMIC_DOMAIN', '[509, 605]': 'cd00063', '[1146, 1300]': 'G3DSA:2.60.120.260', '[1, 19]': 'SignalP-TM', '[509, 617]': 'G3DSA:2.60.40.10', '[508, 609]': 'PS50853', '[6, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[681, 845]': 'G3DSA:2.60.120.260', '[85, 405]': 'SSF51445', '[1160, 1280]': 'PF02018', '[19, 27]': 'SIGNAL_PEPTIDE_C_REGION', '[1160, 1295]': 'SSF49785', '[397, 503]': 'G3DSA:2.60.40.1180', '[681, 814]': 'PF02018'}, 'QHS51394.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 19]': 'SIGNAL_PEPTIDE', '[474, 789]': 'G3DSA:3.20.20.80', '[484, 782]': 'PF02156', '[697, 709]': 'PR00739', '[484, 774]': 'SSF51445', '[658, 681]': 'PR00739', '[1, 22]': 'SignalP-TM', '[554, 568]': 'PR00739', '[4, 14]': 'SIGNAL_PEPTIDE_H_REGION', '[20, 790]': 'NON_CYTOPLASMIC_DOMAIN', '[630, 647]': 'PR00739', '[483, 782]': 'PS51764', '[83, 372]': 'G3DSA:3.20.20.80', '[64, 372]': 'SSF51445', '[15, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[468, 750]': 'PTHR40079'}, 'QWG05959.1': {'[42, 374]': 'G3DSA:3.20.20.80', '[1, 28]': 'SIGNAL_PEPTIDE', '[1, 30]': 'SignalP-TM', '[29, 512]': 'NON_CYTOPLASMIC_DOMAIN', '[11, 22]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[23, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[115, 378]': 'SSF51445'}, 'ANQ50808.1': {'[1, 25]': 'SignalP-TM', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[28, 364]': 'G3DSA:3.20.20.80', '[6, 17]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 22]': 'SignalP-noTM', '[18, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[23, 506]': 'NON_CYTOPLASMIC_DOMAIN', '[72, 372]': 'SSF51445'}, 'QWG01382.1': {'[21, 521]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 20]': 'PS51257', '[57, 315]': 'SSF51445', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[34, 316]': 'G3DSA:3.20.20.80', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'UII20690.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 18]': 'PS51257', '[1, 19]': 'SignalP-noTM', '[4, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 20]': 'SignalP-noTM', '[92, 383]': 'SSF51445', '[36, 395]': 'G3DSA:3.20.20.80', '[21, 514]': 'NON_CYTOPLASMIC_DOMAIN'}, 'UII20686.1': {'[18, 25]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[35, 363]': 'G3DSA:3.20.20.80', '[26, 490]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 25]': 'SignalP-noTM', '[4, 17]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 16]': 'SignalP-noTM', '[43, 375]': 'SSF51445'}, 'WPO86937.1': {'[579, 645]': 'PF13290', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[21, 29]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 29]': 'SIGNAL_PEPTIDE', '[727, 880]': 'G3DSA:2.60.120.260', '[94, 373]': 'SSF51445', '[1, 32]': 'PS51318', '[163, 375]': 'G3DSA:3.20.20.80', '[795, 865]': 'SSF49785', '[727, 837]': 'PF22825', '[30, 882]': 'NON_CYTOPLASMIC_DOMAIN', '[8, 20]': 'SIGNAL_PEPTIDE_H_REGION', '[7, 29]': 'TMhelix'}, 'WPO86936.1': {'[1, 33]': 'SIGNAL_PEPTIDE', '[26, 33]': 'SIGNAL_PEPTIDE_C_REGION', '[10, 25]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[34, 1129]': 'NON_CYTOPLASMIC_DOMAIN', '[569, 632]': 'PF13290'}, 'WEV39865.1': {'[1, 20]': 'SignalP-noTM', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[20, 31]': 'SIGNAL_PEPTIDE_C_REGION', '[40, 193]': 'G3DSA:2.60.120.260', '[1, 31]': 'SIGNAL_PEPTIDE', '[9, 31]': 'TMhelix', '[32, 658]': 'NON_CYTOPLASMIC_DOMAIN', '[217, 553]': 'SSF51445', '[8, 19]': 'SIGNAL_PEPTIDE_H_REGION', '[51, 171]': 'SSF49785', '[238, 555]': 'G3DSA:3.20.20.80'}, 'QHO70380.1': {'[425, 527]': 'G3DSA:2.60.40.1180', '[1, 1]': 'SIGNAL_PEPTIDE_N_REGION', '[548, 687]': 'G3DSA:2.60.120.260', '[1, 21]': 'SIGNAL_PEPTIDE', '[2, 13]': 'SIGNAL_PEPTIDE_H_REGION', '[22, 972]': 'NON_CYTOPLASMIC_DOMAIN', '[14, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[37, 383]': 'G3DSA:3.20.20.80', '[67, 383]': 'SSF51445', '[690, 823]': 'G3DSA:2.60.120.260'}, 'APF34734.1': {'[889, 993]': 'G3DSA:2.60.40.10', '[576, 642]': 'PF13290', '[5, 27]': 'TMhelix', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 33]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 33]': 'SIGNAL_PEPTIDE', '[95, 374]': 'SSF51445', '[726, 878]': 'G3DSA:2.60.120.260', '[34, 1072]': 'NON_CYTOPLASMIC_DOMAIN', '[158, 378]': 'G3DSA:3.20.20.80'}, 'BAJ75160.1': {'[570, 636]': 'PF13290', '[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 34]': 'PS51318', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[718, 867]': 'G3DSA:2.60.120.260', '[1, 26]': 'SignalP-noTM', '[873, 1025]': 'G3DSA:2.60.120.260', '[11, 26]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 33]': 'SignalP-noTM', '[67, 367]': 'G3DSA:3.20.20.80', '[35, 1027]': 'NON_CYTOPLASMIC_DOMAIN', '[71, 349]': 'SSF51445'}, 'BAJ74095.1': {'[64, 329]': 'G3DSA:3.20.20.80', '[23, 30]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 30]': 'SignalP-noTM', '[7, 22]': 'SIGNAL_PEPTIDE_H_REGION', '[719, 869]': 'G3DSA:2.60.120.260', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION', '[569, 634]': 'PF13290', '[7, 29]': 'TMhelix', '[31, 965]': 'NON_CYTOPLASMIC_DOMAIN', '[56, 324]': 'SSF51445'}, 'AHF17862.1': {'[1, 28]': 'SignalP-TM', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[27, 473]': 'NON_CYTOPLASMIC_DOMAIN', '[85, 366]': 'SSF51445', '[10, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[44, 317]': 'G3DSA:3.20.20.80', '[22, 26]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 26]': 'SIGNAL_PEPTIDE'}, 'AHF89993.1': {'[25, 33]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 27]': 'SignalP-noTM', '[13, 24]': 'SIGNAL_PEPTIDE_H_REGION', '[61, 376]': 'G3DSA:3.20.20.80', '[466, 486]': 'mobidb-lite', '[34, 508]': 'NON_CYTOPLASMIC_DOMAIN', '[75, 363]': 'SSF51445', '[1, 35]': 'SignalP-TM', '[1, 12]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 33]': 'SIGNAL_PEPTIDE', '[7, 26]': 'TMhelix'}, 'AHF91408.1': {'[531, 546]': 'mobidb-lite', '[524, 546]': 'mobidb-lite', '[51, 370]': 'G3DSA:3.20.20.80', '[34, 358]': 'SSF51445'}, 'WFR61027.1': {'[77, 377]': 'G3DSA:3.20.20.80', '[78, 377]': 'SSF51445', '[35, 861]': 'NON_CYTOPLASMIC_DOMAIN', '[16, 26]': 'SIGNAL_PEPTIDE_H_REGION', '[588, 648]': 'PF13290', '[1, 15]': 'SIGNAL_PEPTIDE_N_REGION', '[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 34]': 'SignalP-TM', '[12, 34]': 'TMhelix', '[1, 28]': 'SignalP-noTM'}, 'ANF97338.1': {'[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 34]': 'SignalP-noTM', '[76, 376]': 'SSF51445', '[1, 14]': 'SIGNAL_PEPTIDE_N_REGION', '[687, 752]': 'PF13290', '[31, 356]': 'G3DSA:3.20.20.80', '[557, 593]': 'mobidb-lite', '[835, 987]': 'G3DSA:2.60.120.260', '[1, 27]': 'SignalP-noTM', '[7, 29]': 'TMhelix', '[248, 306]': 'PF11790', '[35, 1155]': 'NON_CYTOPLASMIC_DOMAIN', '[554, 593]': 'mobidb-lite', '[997, 1152]': 'G3DSA:2.60.120.260', '[15, 26]': 'SIGNAL_PEPTIDE_H_REGION'}, 'WPP43235.1': {'[583, 653]': 'mobidb-lite', '[59, 344]': 'SSF51445', '[189, 306]': 'PF11790', '[943, 1027]': 'SSF49785', '[22, 29]': 'SIGNAL_PEPTIDE_C_REGION', '[1042, 1198]': 'G3DSA:2.60.120.260', '[731, 797]': 'PF13290', '[11, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[926, 1028]': 'G3DSA:2.60.120.260', '[1, 30]': 'SignalP-noTM', '[49, 348]': 'G3DSA:3.20.20.80', '[520, 563]': 'mobidb-lite', '[583, 613]': 'mobidb-lite', '[1, 29]': 'SIGNAL_PEPTIDE', '[1031, 1062]': 'mobidb-lite', '[1, 38]': 'SignalP-TM', '[12, 31]': 'TMhelix', '[30, 1199]': 'NON_CYTOPLASMIC_DOMAIN', '[627, 653]': 'mobidb-lite'}, 'ANY71428.1': {'[26, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[14, 25]': 'SIGNAL_PEPTIDE_H_REGION', '[726, 874]': 'G3DSA:2.60.120.260', '[1, 32]': 'SignalP-noTM', '[882, 1032]': 'G3DSA:2.60.120.260', '[1, 13]': 'SIGNAL_PEPTIDE_N_REGION', '[792, 873]': 'SSF49785', '[33, 1033]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 31]': 'SignalP-noTM', '[64, 372]': 'SSF51445', '[73, 372]': 'G3DSA:3.20.20.80', '[189, 307]': 'PF11790', '[578, 643]': 'PF13290'}, 'WCT54208.1': {'[638, 704]': 'PF13290', '[1016, 1085]': 'SSF49785', '[8, 23]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[24, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[33, 1101]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 32]': 'SignalP-noTM', '[784, 935]': 'G3DSA:2.60.120.260', '[945, 1100]': 'G3DSA:2.60.120.260', '[60, 336]': 'SSF51445', '[70, 343]': 'G3DSA:3.20.20.80', '[7, 26]': 'TMhelix'}, 'AYB42811.1': {'[63, 381]': 'G3DSA:3.20.20.80', '[575, 648]': 'cd00063', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[22, 29]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 29]': 'SIGNAL_PEPTIDE', '[561, 654]': 'PS50853', '[30, 845]': 'NON_CYTOPLASMIC_DOMAIN', '[185, 321]': 'PF11790', '[566, 658]': 'G3DSA:2.60.40.10', '[8, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[7, 29]': 'TMhelix', '[52, 363]': 'SSF51445'}, 'QGG55106.1': {'[644, 755]': 'PF00754', '[423, 484]': 'mobidb-lite', '[587, 608]': 'mobidb-lite', '[91, 408]': 'G3DSA:3.20.20.80', '[626, 773]': 'G3DSA:2.60.120.260', '[611, 774]': 'PS50022', '[642, 774]': 'SSF49785', '[110, 413]': 'SSF51445', '[781, 834]': 'mobidb-lite'}, 'WJH29034.1': {'[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[84, 380]': 'SSF51445', '[1, 34]': 'SignalP-TM', '[1, 14]': 'SIGNAL_PEPTIDE_N_REGION', '[959, 1038]': 'SSF49785', '[35, 1203]': 'NON_CYTOPLASMIC_DOMAIN', '[911, 1040]': 'PS51175', '[79, 380]': 'G3DSA:3.20.20.80', '[736, 883]': 'G3DSA:2.60.120.260', '[12, 34]': 'TMhelix', '[1072, 1200]': 'G3DSA:2.60.120.260', '[593, 651]': 'PF13290', '[1, 25]': 'SignalP-noTM', '[15, 26]': 'SIGNAL_PEPTIDE_H_REGION', '[942, 1039]': 'G3DSA:2.60.120.260'}, 'QNK55806.1': {'[504, 603]': 'SSF49265', '[25, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[689, 837]': 'SSF49785', '[509, 618]': 'G3DSA:2.60.40.10', '[420, 500]': 'SSF51011', '[683, 814]': 'PF02018', '[10, 24]': 'SIGNAL_PEPTIDE_H_REGION', '[71, 342]': 'G3DSA:3.20.20.80', '[1147, 1301]': 'G3DSA:2.60.120.260', '[396, 503]': 'G3DSA:2.60.40.1180', '[508, 609]': 'PS50853', '[33, 1301]': 'NON_CYTOPLASMIC_DOMAIN', '[996, 1118]': 'PF02018', '[958, 1146]': 'G3DSA:2.60.120.260', '[1, 32]': 'SIGNAL_PEPTIDE', '[989, 1010]': 'mobidb-lite', '[1, 27]': 'SignalP-TM', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[1159, 1296]': 'SSF49785', '[7, 24]': 'TMhelix', '[1158, 1281]': 'PF02018', '[112, 405]': 'SSF51445', '[996, 1010]': 'mobidb-lite', '[681, 845]': 'G3DSA:2.60.120.260', '[1, 25]': 'SignalP-noTM'}, 'QNK57010.1': {'[31, 42]': 'SIGNAL_PEPTIDE_C_REGION', '[43, 1196]': 'NON_CYTOPLASMIC_DOMAIN', '[1044, 1196]': 'G3DSA:2.60.120.260', '[168, 380]': 'G3DSA:3.20.20.80', '[886, 1037]': 'G3DSA:2.60.120.260', '[1113, 1191]': 'SSF49785', '[1, 18]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 42]': 'SignalP-TM', '[582, 644]': 'PF13290', '[763, 879]': 'G3DSA:2.60.120.260', '[13, 35]': 'TMhelix', '[796, 861]': 'SSF49785', '[192, 306]': 'PF11790', '[100, 380]': 'SSF51445', '[19, 30]': 'SIGNAL_PEPTIDE_H_REGION'}, 'QNK57015.1': {'[1068, 1191]': 'PF00963', '[37, 348]': 'G3DSA:3.20.20.80', '[1, 30]': 'SignalP-TM', '[24, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[753, 867]': 'G3DSA:2.60.120.260', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[571, 635]': 'PF13290', '[1024, 1060]': 'mobidb-lite', '[887, 1045]': 'G3DSA:2.60.120.260', '[1290, 1358]': 'PF07554', '[1368, 1426]': 'G3DSA:1.10.1330.10', '[90, 347]': 'SSF51445', '[242, 298]': 'PF11790', '[1, 28]': 'SignalP-noTM', '[1, 32]': 'SignalP-noTM', '[1289, 1366]': 'G3DSA:1.20.1270.90', '[1209, 1275]': 'PF07554', '[1208, 1284]': 'G3DSA:1.20.1270.90', '[1054, 1207]': 'G3DSA:2.60.40.680', '[1059, 1187]': 'SSF49384', '[10, 23]': 'SIGNAL_PEPTIDE_H_REGION', '[1068, 1209]': 'cd08547', '[33, 1428]': 'NON_CYTOPLASMIC_DOMAIN'}, 'WMJ22082.1': {'[21, 319]': 'SSF51445', '[346, 435]': 'G3DSA:2.60.40.1180'}, 'UVQ47681.1': {'[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 27]': 'TMhelix', '[14, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[835, 1153]': 'PTHR42767', '[374, 396]': 'PR00743', '[737, 1062]': 'SSF51445', '[480, 496]': 'PR00743', '[295, 495]': 'cd14791', '[1050, 1155]': 'G3DSA:2.60.40.1180', '[1, 21]': 'SIGNAL_PEPTIDE', '[55, 256]': 'G3DSA:2.70.98.60', '[291, 578]': 'G3DSA:3.20.20.70', '[5, 13]': 'SIGNAL_PEPTIDE_H_REGION', '[318, 333]': 'PR00743', '[302, 609]': 'SSF51445', '[22, 1158]': 'NON_CYTOPLASMIC_DOMAIN', '[193, 208]': 'PR00743', '[317, 508]': 'PF02065', '[709, 1030]': 'G3DSA:3.20.20.80'}, 'BDD02170.1': {'[1, 2]': 'SIGNAL_PEPTIDE_N_REGION', '[20, 502]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 19]': 'SIGNAL_PEPTIDE', '[131, 279]': 'G3DSA:3.20.20.80', '[15, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[3, 14]': 'SIGNAL_PEPTIDE_H_REGION', '[37, 279]': 'SSF51445'}, 'BDD02164.1': {'[24, 397]': 'G3DSA:3.20.20.80', '[1, 20]': 'SIGNAL_PEPTIDE', '[21, 518]': 'NON_CYTOPLASMIC_DOMAIN', '[420, 517]': 'G3DSA:2.60.40.1180', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[64, 313]': 'SSF51445', '[1, 18]': 'PS51257', '[6, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'SignalP-TM', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[181, 313]': 'PF00150'}, 'AGB28643.1': {'[1, 22]': 'SIGNAL_PEPTIDE', '[7, 29]': 'TMhelix', '[366, 698]': 'PTHR42767', '[295, 609]': 'SSF51445', '[23, 704]': 'NON_CYTOPLASMIC_DOMAIN', '[7, 17]': 'SIGNAL_PEPTIDE_H_REGION', '[260, 573]': 'G3DSA:3.20.20.80', '[18, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'AGB28629.1': {'[302, 607]': 'SSF51445', '[18, 24]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 24]': 'SignalP-noTM', '[761, 1067]': 'SSF51445', '[295, 585]': 'G3DSA:3.20.20.70', '[25, 1164]': 'NON_CYTOPLASMIC_DOMAIN', '[738, 1064]': 'G3DSA:3.20.20.80', '[320, 514]': 'PF02065', '[43, 258]': 'G3DSA:2.70.98.60', '[9, 17]': 'SIGNAL_PEPTIDE_H_REGION'}, 'QMW75430.1': {'[331, 484]': 'G3DSA:2.60.120.260', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[988, 1005]': 'TRANSMEMBRANE', '[1006, 1009]': 'CYTOPLASMIC_DOMAIN', '[8, 19]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 28]': 'SignalP-TM', '[32, 157]': 'PF02018', '[9, 28]': 'TMhelix', '[183, 330]': 'G3DSA:2.60.120.260', '[579, 808]': 'SSF51445', '[1, 30]': 'SignalP-TM', '[29, 987]': 'NON_CYTOPLASMIC_DOMAIN', '[333, 466]': 'PF02018', '[20, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[955, 975]': 'Coil', '[25, 182]': 'G3DSA:2.60.120.260', '[329, 487]': 'SSF49785', '[190, 328]': 'SSF49785', '[31, 181]': 'SSF49785'}, 'QQV06122.1': {'[1061, 1137]': 'SM00635', '[1605, 1646]': 'Coil', '[1511, 1531]': 'Coil', '[1672, 1692]': 'Coil', '[1, 39]': 'SignalP-noTM', '[829, 910]': 'SM00635', '[1141, 1275]': 'G3DSA:2.60.120.260', '[73, 362]': 'SSF51445', '[40, 1738]': 'NON_CYTOPLASMIC_DOMAIN', '[1740, 1759]': 'TMhelix', '[1150, 1270]': 'PF00754', '[1282, 1358]': 'SM00635', '[1648, 1735]': 'G3DSA:1.20.1270.90', '[829, 914]': 'G3DSA:2.60.40.1080', '[19, 30]': 'SIGNAL_PEPTIDE_H_REGION', '[1710, 1734]': 'mobidb-lite', '[31, 39]': 'SIGNAL_PEPTIDE_C_REGION', '[1282, 1359]': 'SSF49373', '[832, 904]': 'PF02368', '[1058, 1140]': 'G3DSA:2.60.40.1080', '[1061, 1125]': 'PF02368', '[1513, 1586]': 'G3DSA:1.20.1270.90', '[1759, 1766]': 'CYTOPLASMIC_DOMAIN', '[1, 18]': 'SIGNAL_PEPTIDE_N_REGION', '[1739, 1758]': 'TRANSMEMBRANE', '[20, 37]': 'TMhelix', '[1541, 1561]': 'Coil', '[1282, 1361]': 'G3DSA:2.60.40.1080', '[1059, 1139]': 'SSF49373', '[1132, 1277]': 'PS50022', '[1441, 1461]': 'Coil', '[587, 670]': 'SM00635', '[1710, 1731]': 'mobidb-lite', '[1148, 1276]': 'SSF49785'}, 'ADB80105.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[38, 355]': 'G3DSA:3.20.20.80', '[1, 20]': 'SignalP-noTM', '[4, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[63, 359]': 'SSF51445', '[21, 477]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 21]': 'PS51257'}, 'CAZ94303.1': {'[1, 23]': 'SignalP-TM', '[23, 517]': 'NON_CYTOPLASMIC_DOMAIN', '[36, 384]': 'G3DSA:3.20.20.80', '[1, 21]': 'SignalP-noTM', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[18, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 22]': 'SIGNAL_PEPTIDE', '[69, 300]': 'SSF51445', '[1, 17]': 'PS51257', '[9, 17]': 'SIGNAL_PEPTIDE_H_REGION'}, 'CBK67650.1': {'[711, 1037]': 'G3DSA:3.20.20.80', '[318, 333]': 'PR00743', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[321, 586]': 'cd14791', '[1, 21]': 'SignalP-noTM', '[791, 1129]': 'PTHR42767', '[54, 256]': 'G3DSA:2.70.98.60', '[741, 1073]': 'SSF51445', '[308, 626]': 'SSF51445', '[22, 1169]': 'NON_CYTOPLASMIC_DOMAIN', '[492, 508]': 'PR00743', '[314, 521]': 'PF02065', '[374, 396]': 'PR00743', '[16, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[291, 591]': 'G3DSA:3.20.20.70', '[1060, 1167]': 'G3DSA:2.60.40.1180'}}\n",
      "dict_keys(['ATO84721.1', 'BBL06275.1', 'BBL01040.1', 'UWN65549.1', 'CBK63196.1', 'UZO80939.1', 'UZO80937.1', 'AGY53053.1', 'ANU59401.1', 'ANU59398.1', 'UBD71149.1', 'QUT88730.1', 'UWN88717.1', 'UVR10658.1', 'UVO70767.1', 'UVO70768.1', 'QGT72561.1', 'UWO00929.1', 'UWO00930.1', 'UVR93289.1', 'QZU84679.1', 'CBK67267.1', 'QEG33916.1', 'ABP68096.1', 'BDI31947.1', 'ADV49313.1', 'ADV49311.1', 'APU67655.1', 'APU67659.1', 'WLC65246.1', 'QTH43817.1', 'QHS51394.1', 'QWG05959.1', 'ANQ50808.1', 'QWG01382.1', 'UII20690.1', 'UII20686.1', 'WPO86937.1', 'WPO86936.1', 'WEV39865.1', 'QHO70380.1', 'APF34734.1', 'BAJ75160.1', 'BAJ74095.1', 'AHF17862.1', 'AHF89993.1', 'AHF91408.1', 'WFR61027.1', 'ANF97338.1', 'WPP43235.1', 'ANY71428.1', 'WCT54208.1', 'AYB42811.1', 'QGG55106.1', 'WJH29034.1', 'QNK55806.1', 'QNK57010.1', 'QNK57015.1', 'WMJ22082.1', 'UVQ47681.1', 'BDD02170.1', 'BDD02164.1', 'AGB28643.1', 'AGB28629.1', 'QMW75430.1', 'QQV06122.1', 'ADB80105.1', 'CAZ94303.1', 'CBK67650.1'])\n",
      "\n",
      "\n",
      "{'ATO84721.1': [[5, 18], [1, 26], [19, 26], [27, 620], [1, 26], [1, 4], [1, 18], [333, 503], [1, 26], [358, 495]], 'BBL06275.1': [[86, 340], [4, 240]], 'BBL01040.1': [[15, 251], [22, 352], [30, 348]], 'UWN65549.1': [[1, 25], [26, 526], [1, 25], [1, 25], [125, 430], [1, 8], [189, 523], [97, 430], [1, 20], [26, 45], [1, 25], [9, 20], [21, 25]], 'CBK63196.1': [[1, 20], [59, 384], [7, 16], [21, 493], [47, 381], [1, 20], [17, 20], [1, 20], [1, 21], [1, 19], [1, 6]], 'UZO80939.1': [[24, 506], [1, 30], [19, 23], [1, 9], [1, 23], [1, 23], [45, 306], [10, 18], [75, 373], [53, 300], [1, 22], [1, 22]], 'UZO80937.1': [[5, 16], [21, 521], [89, 353], [70, 314], [1, 4], [1, 20], [17, 20], [1, 24], [1, 20], [74, 317]], 'AGY53053.1': [[1, 22], [5, 16], [31, 377], [1, 24], [5, 27], [1, 4], [23, 489], [1, 18], [1, 22], [1, 22], [17, 22], [57, 284]], 'ANU59401.1': [[181, 436], [27, 533], [1, 26], [65, 434], [22, 26], [1, 24], [1, 25], [11, 21], [1, 10], [188, 531], [1, 26], [1, 24]], 'ANU59398.1': [[50, 256], [308, 626], [318, 333], [791, 1129], [314, 521], [1, 4], [5, 15], [722, 1071], [321, 586], [22, 1169], [291, 591], [1, 21], [492, 508], [1, 21], [374, 396], [1, 21], [743, 1073], [16, 21]], 'UBD71149.1': [[1, 19], [18, 485], [1, 3], [4, 12], [39, 360], [1, 19], [1, 17], [16, 351], [13, 17]], 'QUT88730.1': [[1, 5], [1, 20], [21, 493], [1, 22], [57, 390], [1, 18], [6, 15], [16, 20], [67, 349], [1, 20], [1, 20]], 'UWN88717.1': [[1, 19], [1, 4], [16, 19], [5, 15], [79, 362], [1, 19], [1, 19], [40, 302], [1, 21], [20, 471], [1, 19]], 'UVR10658.1': [[161, 461], [178, 496], [930, 1037], [184, 391], [244, 266], [661, 999], [362, 378], [582, 907], [2, 126], [613, 943], [188, 203], [191, 456]], 'UVO70767.1': [[19, 289], [36, 291], [43, 386]], 'UVO70768.1': [[1, 24], [1, 8], [1, 22], [25, 144], [1, 24], [9, 19], [1, 23], [20, 24], [1, 22]], 'QGT72561.1': [[5, 16], [1, 21], [1, 4], [1, 21], [41, 375], [37, 346], [22, 487], [17, 21], [1, 16]], 'UWO00929.1': [[42, 278], [1, 2], [1, 22], [36, 352], [1, 23], [15, 22], [1, 22], [43, 379], [23, 490], [3, 14]], 'UWO00930.1': [[46, 372], [1, 18], [20, 505], [1, 19], [16, 19], [7, 15], [1, 19], [1, 6], [74, 364]], 'UVR93289.1': [[19, 23], [7, 18], [1, 23], [58, 366], [1, 23], [24, 377], [1, 21], [24, 497], [1, 6]], 'QZU84679.1': [[1, 3], [20, 509], [16, 19], [21, 374], [1, 19], [61, 301], [4, 15], [1, 19]], 'CBK67267.1': [[19, 23], [7, 18], [1, 23], [1, 20], [1, 23], [24, 495], [44, 288], [22, 378], [1, 6]], 'QEG33916.1': [[27, 330], [44, 315]], 'ABP68096.1': [[499, 627], [11, 23], [1, 10], [75, 307], [1, 28], [24, 28], [7, 29], [391, 574], [15, 378], [511, 623], [29, 628], [57, 347], [377, 492], [493, 628], [501, 627], [1, 28]], 'BDI31947.1': [[1, 27], [1, 27], [23, 30], [1, 30], [67, 342], [11, 22], [1, 27], [1, 10], [97, 390], [31, 507]], 'ADV49313.1': [[6, 16], [401, 512], [22, 514], [70, 382], [1, 5], [1, 21], [28, 393], [1, 21], [17, 21]], 'ADV49311.1': [[6, 16], [1, 5], [1, 20], [21, 505], [1, 20], [54, 291], [17, 20], [1, 20], [47, 365], [1, 20]], 'APU67655.1': [[45, 382], [7, 18], [19, 22], [1, 22], [69, 291], [23, 516], [1, 20], [1, 26], [74, 385], [1, 6]], 'APU67659.1': [[50, 364], [1, 9], [7, 29], [10, 21], [1, 28], [29, 494], [1, 28], [22, 28], [22, 375]], 'WLC65246.1': [[506, 528], [51, 387], [12, 34], [1, 11], [506, 527], [33, 505], [314, 336], [528, 530], [12, 32], [60, 386]], 'QTH43817.1': [[64, 343], [995, 1145], [1, 5], [1, 27], [506, 605], [683, 838], [28, 1300], [509, 605], [1146, 1300], [1, 19], [509, 617], [508, 609], [6, 18], [681, 845], [85, 405], [1160, 1280], [19, 27], [1160, 1295], [397, 503], [681, 814]], 'QHS51394.1': [[1, 3], [1, 19], [474, 789], [484, 782], [697, 709], [484, 774], [658, 681], [1, 22], [554, 568], [4, 14], [1, 19], [20, 790], [630, 647], [483, 782], [83, 372], [64, 372], [15, 19], [1, 19], [468, 750]], 'QWG05959.1': [[42, 374], [1, 28], [1, 30], [29, 512], [1, 28], [11, 22], [1, 10], [1, 28], [23, 28], [115, 378]], 'ANQ50808.1': [[1, 25], [1, 5], [28, 364], [6, 17], [1, 22], [18, 22], [23, 506], [1, 22], [72, 372]], 'QWG01382.1': [[21, 521], [1, 20], [57, 315], [16, 20], [7, 15], [1, 20], [1, 20], [34, 316], [1, 6]], 'UII20690.1': [[1, 3], [1, 18], [1, 19], [1, 19], [4, 15], [16, 20], [1, 20], [1, 20], [92, 383], [36, 395], [21, 514]], 'UII20686.1': [[18, 25], [1, 3], [35, 363], [26, 490], [1, 25], [4, 17], [1, 25], [1, 25], [1, 16], [43, 375]], 'WPO86937.1': [[579, 645], [1, 7], [21, 29], [1, 29], [727, 880], [94, 373], [1, 32], [163, 375], [1, 29], [1, 29], [795, 865], [727, 837], [30, 882], [8, 20], [1, 32], [7, 29]], 'WPO86936.1': [[1, 33], [26, 33], [1, 33], [1, 33], [10, 25], [1, 9], [34, 1129], [569, 632], [1, 33]], 'WEV39865.1': [[1, 20], [1, 7], [20, 31], [40, 193], [1, 31], [9, 31], [32, 658], [217, 553], [8, 19], [1, 31], [51, 171], [238, 555]], 'QHO70380.1': [[425, 527], [1, 1], [548, 687], [1, 21], [2, 13], [22, 972], [14, 21], [37, 383], [67, 383], [690, 823]], 'APF34734.1': [[889, 993], [576, 642], [5, 27], [1, 4], [5, 15], [16, 33], [1, 33], [95, 374], [726, 878], [34, 1072], [1, 33], [158, 378], [1, 33]], 'BAJ75160.1': [[570, 636], [27, 34], [1, 34], [1, 10], [718, 867], [1, 26], [1, 34], [873, 1025], [11, 26], [1, 34], [1, 33], [67, 367], [35, 1027], [71, 349]], 'BAJ74095.1': [[64, 329], [23, 30], [1, 30], [1, 30], [7, 22], [1, 30], [719, 869], [1, 6], [1, 30], [1, 30], [569, 634], [7, 29], [31, 965], [56, 324]], 'AHF17862.1': [[1, 28], [1, 9], [27, 473], [85, 366], [10, 21], [44, 317], [22, 26], [1, 28], [1, 28], [1, 26]], 'AHF89993.1': [[25, 33], [1, 27], [13, 24], [61, 376], [466, 486], [34, 508], [75, 363], [1, 35], [1, 12], [1, 33], [7, 26]], 'AHF91408.1': [[531, 546], [524, 546], [51, 370], [34, 358]], 'WFR61027.1': [[77, 377], [78, 377], [35, 861], [16, 26], [588, 648], [1, 15], [27, 34], [1, 34], [12, 34], [1, 34], [1, 28]], 'ANF97338.1': [[27, 34], [1, 34], [1, 34], [76, 376], [1, 14], [687, 752], [31, 356], [1, 34], [557, 593], [835, 987], [1, 27], [7, 29], [248, 306], [35, 1155], [554, 593], [997, 1152], [15, 26]], 'WPP43235.1': [[583, 653], [59, 344], [189, 306], [943, 1027], [22, 29], [1042, 1198], [731, 797], [11, 21], [1, 10], [926, 1028], [1, 30], [49, 348], [520, 563], [583, 613], [1, 29], [1, 29], [1031, 1062], [1, 38], [12, 31], [30, 1199], [627, 653]], 'ANY71428.1': [[26, 32], [14, 25], [726, 874], [1, 32], [882, 1032], [1, 13], [792, 873], [33, 1033], [1, 32], [1, 31], [64, 372], [1, 32], [73, 372], [189, 307], [578, 643]], 'WCT54208.1': [[638, 704], [1016, 1085], [8, 23], [1, 7], [24, 32], [33, 1101], [1, 32], [784, 935], [945, 1100], [60, 336], [70, 343], [1, 32], [1, 32], [1, 32], [7, 26]], 'AYB42811.1': [[63, 381], [575, 648], [1, 7], [22, 29], [1, 29], [561, 654], [30, 845], [1, 29], [185, 321], [566, 658], [8, 21], [1, 29], [7, 29], [52, 363], [575, 648]], 'QGG55106.1': [[644, 755], [423, 484], [587, 608], [91, 408], [626, 773], [611, 774], [642, 774], [110, 413], [781, 834]], 'WJH29034.1': [[27, 34], [84, 380], [1, 34], [1, 14], [959, 1038], [35, 1203], [911, 1040], [79, 380], [1, 34], [736, 883], [12, 34], [1072, 1200], [593, 651], [1, 25], [1, 34], [15, 26], [942, 1039]], 'QNK55806.1': [[504, 603], [25, 32], [689, 837], [509, 618], [420, 500], [683, 814], [10, 24], [71, 342], [1147, 1301], [396, 503], [508, 609], [33, 1301], [996, 1118], [958, 1146], [1, 32], [989, 1010], [1, 27], [1, 9], [1159, 1296], [7, 24], [1158, 1281], [1, 27], [112, 405], [996, 1010], [681, 845], [1, 25]], 'QNK57010.1': [[31, 42], [43, 1196], [1044, 1196], [168, 380], [886, 1037], [1113, 1191], [1, 18], [1, 42], [582, 644], [763, 879], [1, 42], [13, 35], [796, 861], [192, 306], [100, 380], [19, 30]], 'QNK57015.1': [[1068, 1191], [37, 348], [1, 30], [24, 32], [753, 867], [1, 9], [571, 635], [1024, 1060], [887, 1045], [1290, 1358], [1368, 1426], [90, 347], [242, 298], [1, 28], [1, 32], [1289, 1366], [1209, 1275], [1208, 1284], [1054, 1207], [1059, 1187], [1, 32], [10, 23], [1068, 1209], [33, 1428]], 'WMJ22082.1': [[21, 319], [346, 435]], 'UVQ47681.1': [[1, 4], [5, 27], [14, 21], [835, 1153], [374, 396], [737, 1062], [480, 496], [295, 495], [1050, 1155], [1, 21], [55, 256], [291, 578], [5, 13], [318, 333], [302, 609], [22, 1158], [193, 208], [317, 508], [709, 1030]], 'BDD02170.1': [[1, 2], [20, 502], [1, 19], [131, 279], [15, 19], [1, 19], [3, 14], [37, 279]], 'BDD02164.1': [[24, 397], [1, 20], [21, 518], [420, 517], [1, 5], [64, 313], [1, 18], [6, 15], [1, 23], [16, 20], [181, 313], [1, 20]], 'AGB28643.1': [[1, 22], [7, 29], [366, 698], [1, 22], [295, 609], [23, 704], [7, 17], [260, 573], [1, 22], [18, 22], [1, 6]], 'AGB28629.1': [[302, 607], [18, 24], [1, 8], [1, 24], [1, 24], [761, 1067], [295, 585], [25, 1164], [1, 24], [738, 1064], [320, 514], [43, 258], [1, 24], [9, 17]], 'QMW75430.1': [[331, 484], [1, 7], [988, 1005], [1006, 1009], [8, 19], [1, 28], [32, 157], [9, 28], [183, 330], [579, 808], [1, 30], [29, 987], [988, 1005], [333, 466], [1, 28], [20, 28], [955, 975], [25, 182], [329, 487], [190, 328], [31, 181]], 'QQV06122.1': [[1061, 1137], [1605, 1646], [1511, 1531], [1672, 1692], [1, 39], [829, 910], [1, 39], [1141, 1275], [73, 362], [40, 1738], [1740, 1759], [1150, 1270], [1282, 1358], [1648, 1735], [829, 914], [19, 30], [1710, 1734], [31, 39], [1282, 1359], [832, 904], [1058, 1140], [1, 39], [1061, 1125], [1513, 1586], [1759, 1766], [1, 18], [1739, 1758], [20, 37], [1541, 1561], [1282, 1361], [1059, 1139], [1132, 1277], [1441, 1461], [1, 39], [587, 670], [1710, 1731], [1148, 1276]], 'ADB80105.1': [[1, 3], [38, 355], [1, 20], [1, 20], [4, 15], [16, 20], [63, 359], [21, 477], [1, 20], [1, 21], [1, 20]], 'CAZ94303.1': [[1, 23], [23, 517], [36, 384], [1, 21], [1, 8], [18, 22], [1, 22], [69, 300], [1, 17], [9, 17], [1, 23]], 'CBK67650.1': [[711, 1037], [318, 333], [1, 4], [5, 15], [321, 586], [1, 21], [791, 1129], [54, 256], [741, 1073], [308, 626], [22, 1169], [1, 21], [492, 508], [314, 521], [374, 396], [1, 21], [16, 21], [291, 591], [1060, 1167]]}\n",
      "\n",
      "\n",
      "{'ATO84721.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445']], 'BBL06275.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445']], 'BBL01040.1': [['PFAM', 'PF00150'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445']], 'UWN65549.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PANTHER', 'PTHR42767'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PROSITE_PROFILES', 'PS51257'], ['MOBIDB_LITE', 'mobidb-lite'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'CBK63196.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'UZO80939.1': [['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', 'SSF51445'], ['PFAM', 'PF00150'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'PS51257']], 'UZO80937.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'PF00150']], 'AGY53053.1': [['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'PS51257'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF51445']], 'ANU59401.1': [['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PANTHER', 'PTHR42767'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM']], 'ANU59398.1': [['GENE3D', 'G3DSA:2.70.98.60'], ['SUPERFAMILY', 'SSF51445'], ['PRINTS', 'PR00743'], ['PANTHER', 'PTHR42767'], ['PFAM', 'PF02065'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['CDD', 'cd14791'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'G3DSA:3.20.20.70'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PRINTS', 'PR00743'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PRINTS', 'PR00743'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'UBD71149.1': [['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'QUT88730.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'UWN88717.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM']], 'UVR10658.1': [['GENE3D', 'G3DSA:3.20.20.70'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PFAM', 'PF02065'], ['PRINTS', 'PR00743'], ['PANTHER', 'PTHR42767'], ['PRINTS', 'PR00743'], ['GENE3D', 'G3DSA:3.20.20.80'], ['GENE3D', 'G3DSA:2.70.98.60'], ['SUPERFAMILY', 'SSF51445'], ['PRINTS', 'PR00743'], ['CDD', 'cd14791']], 'UVO70767.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445'], ['PANTHER', 'PTHR42767']], 'UVO70768.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM']], 'QGT72561.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PROSITE_PROFILES', 'PS51257']], 'UWO00929.1': [['PFAM', 'PF00150'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'UWO00930.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'SSF51445']], 'UVR93289.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'QZU84679.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'CBK67267.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PROSITE_PROFILES', 'PS51257'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'QEG33916.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445']], 'ABP68096.1': [['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PFAM', 'PF00150'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['TMHMM', 'TMhelix'], ['PANTHER', 'PTHR45713'], ['SUPERFAMILY', 'SSF51445'], ['PFAM', 'PF00754'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'G3DSA:3.20.20.80'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PROSITE_PROFILES', 'PS50022'], ['SUPERFAMILY', 'SSF49785'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM']], 'BDI31947.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-TM'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN']], 'ADV49313.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'ADV49311.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'PS51257'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'APU67655.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'PF00150'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'PS51257'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'APU67659.1': [['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:3.20.20.80']], 'WLC65246.1': [['TMHMM', 'TMhelix'], ['SUPERFAMILY', 'SSF51445'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'TRANSMEMBRANE'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'TRANSMEMBRANE'], ['GENE3D', 'G3DSA:3.20.20.80']], 'QTH43817.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF49265'], ['SUPERFAMILY', 'SSF49785'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['CDD', 'cd00063'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_EUK', 'SignalP-TM'], ['GENE3D', 'G3DSA:2.60.40.10'], ['PROSITE_PROFILES', 'PS50853'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF51445'], ['PFAM', 'PF02018'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF49785'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PFAM', 'PF02018']], 'QHS51394.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PFAM', 'PF02156'], ['PRINTS', 'PR00739'], ['SUPERFAMILY', 'SSF51445'], ['PRINTS', 'PR00739'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PRINTS', 'PR00739'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PRINTS', 'PR00739'], ['PROSITE_PROFILES', 'PS51764'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PANTHER', 'PTHR40079']], 'QWG05959.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF51445']], 'ANQ50808.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445']], 'QWG01382.1': [['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PROSITE_PROFILES', 'PS51257'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'UII20690.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PROSITE_PROFILES', 'PS51257'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN']], 'UII20686.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445']], 'WPO86937.1': [['PFAM', 'PF13290'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF49785'], ['PFAM', 'PF22825'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PROSITE_PROFILES', 'PS51318'], ['TMHMM', 'TMhelix']], 'WPO86936.1': [['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PFAM', 'PF13290'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'WEV39865.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF49785'], ['GENE3D', 'G3DSA:3.20.20.80']], 'QHO70380.1': [['GENE3D', 'G3DSA:2.60.40.1180'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:2.60.120.260']], 'APF34734.1': [['GENE3D', 'G3DSA:2.60.40.10'], ['PFAM', 'PF13290'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'BAJ75160.1': [['PFAM', 'PF13290'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PROSITE_PROFILES', 'PS51318'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445']], 'BAJ74095.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PROSITE_PROFILES', 'PS51318'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PFAM', 'PF13290'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445']], 'AHF17862.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'AHF89993.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['MOBIDB_LITE', 'mobidb-lite'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['TMHMM', 'TMhelix']], 'AHF91408.1': [['MOBIDB_LITE', 'mobidb-lite'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445']], 'WFR61027.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PFAM', 'PF13290'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['TMHMM', 'TMhelix'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_EUK', 'SignalP-noTM']], 'ANF97338.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PFAM', 'PF13290'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_EUK', 'SignalP-noTM'], ['TMHMM', 'TMhelix'], ['PFAM', 'PF11790'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'WPP43235.1': [['MOBIDB_LITE', 'mobidb-lite'], ['SUPERFAMILY', 'SSF51445'], ['PFAM', 'PF11790'], ['SUPERFAMILY', 'SSF49785'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PFAM', 'PF13290'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['MOBIDB_LITE', 'mobidb-lite'], ['MOBIDB_LITE', 'mobidb-lite'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['MOBIDB_LITE', 'mobidb-lite'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['MOBIDB_LITE', 'mobidb-lite']], 'ANY71428.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'SSF49785'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PFAM', 'PF11790'], ['PFAM', 'PF13290']], 'WCT54208.1': [['PFAM', 'PF13290'], ['SUPERFAMILY', 'SSF49785'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['TMHMM', 'TMhelix']], 'AYB42811.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SUPERFAMILY', 'SSF49265'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'PS50853'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PFAM', 'PF11790'], ['GENE3D', 'G3DSA:2.60.40.10'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['TMHMM', 'TMhelix'], ['SUPERFAMILY', 'SSF51445'], ['CDD', 'cd00063']], 'QGG55106.1': [['PFAM', 'PF00754'], ['MOBIDB_LITE', 'mobidb-lite'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'G3DSA:3.20.20.80'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PROSITE_PROFILES', 'PS50022'], ['SUPERFAMILY', 'SSF49785'], ['SUPERFAMILY', 'SSF51445'], ['MOBIDB_LITE', 'mobidb-lite']], 'WJH29034.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'SSF49785'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'PS51175'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['TMHMM', 'TMhelix'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PFAM', 'PF13290'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:2.60.120.260']], 'QNK55806.1': [['SUPERFAMILY', 'SSF49265'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF49785'], ['GENE3D', 'G3DSA:2.60.40.10'], ['SUPERFAMILY', 'SSF51011'], ['PFAM', 'PF02018'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['GENE3D', 'G3DSA:2.60.120.260'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PROSITE_PROFILES', 'PS50853'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PFAM', 'PF02018'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['MOBIDB_LITE', 'mobidb-lite'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'SSF49785'], ['TMHMM', 'TMhelix'], ['PFAM', 'PF02018'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SUPERFAMILY', 'SSF51445'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM']], 'QNK57010.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'G3DSA:2.60.120.260'], ['GENE3D', 'G3DSA:3.20.20.80'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF49785'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'PF13290'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['SUPERFAMILY', 'SSF49785'], ['PFAM', 'PF11790'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'QNK57015.1': [['PFAM', 'PF00963'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PFAM', 'PF13290'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'G3DSA:2.60.120.260'], ['PFAM', 'PF07554'], ['GENE3D', 'G3DSA:1.10.1330.10'], ['SUPERFAMILY', 'SSF51445'], ['PFAM', 'PF11790'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'G3DSA:1.20.1270.90'], ['PFAM', 'PF07554'], ['GENE3D', 'G3DSA:1.20.1270.90'], ['GENE3D', 'G3DSA:2.60.40.680'], ['SUPERFAMILY', 'SSF49384'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['CDD', 'cd08547'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN']], 'WMJ22082.1': [['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:2.60.40.1180']], 'UVQ47681.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PANTHER', 'PTHR42767'], ['PRINTS', 'PR00743'], ['SUPERFAMILY', 'SSF51445'], ['PRINTS', 'PR00743'], ['CDD', 'cd14791'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'G3DSA:2.70.98.60'], ['GENE3D', 'G3DSA:3.20.20.70'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PRINTS', 'PR00743'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PRINTS', 'PR00743'], ['PFAM', 'PF02065'], ['GENE3D', 'G3DSA:3.20.20.80']], 'BDD02170.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', 'SSF51445']], 'BDD02164.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'G3DSA:2.60.40.1180'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'SSF51445'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PFAM', 'PF00150'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'AGB28643.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PANTHER', 'PTHR42767'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'AGB28629.1': [['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445'], ['GENE3D', 'G3DSA:3.20.20.70'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'G3DSA:3.20.20.80'], ['PFAM', 'PF02065'], ['GENE3D', 'G3DSA:2.70.98.60'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'QMW75430.1': [['GENE3D', 'G3DSA:2.60.120.260'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'PF02018'], ['TMHMM', 'TMhelix'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF51445'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'TRANSMEMBRANE'], ['PFAM', 'PF02018'], ['SIGNALP_EUK', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['COILS', 'Coil'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF49785'], ['SUPERFAMILY', 'SSF49785'], ['SUPERFAMILY', 'SSF49785']], 'QQV06122.1': [['SMART', 'SM00635'], ['COILS', 'Coil'], ['COILS', 'Coil'], ['COILS', 'Coil'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SMART', 'SM00635'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'G3DSA:2.60.120.260'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['TMHMM', 'TMhelix'], ['PFAM', 'PF00754'], ['SMART', 'SM00635'], ['GENE3D', 'G3DSA:1.20.1270.90'], ['GENE3D', 'G3DSA:2.60.40.1080'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['MOBIDB_LITE', 'mobidb-lite'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF49373'], ['PFAM', 'PF02368'], ['GENE3D', 'G3DSA:2.60.40.1080'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PFAM', 'PF02368'], ['GENE3D', 'G3DSA:1.20.1270.90'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'TRANSMEMBRANE'], ['TMHMM', 'TMhelix'], ['COILS', 'Coil'], ['GENE3D', 'G3DSA:2.60.40.1080'], ['SUPERFAMILY', 'SSF49373'], ['PROSITE_PROFILES', 'PS50022'], ['COILS', 'Coil'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SMART', 'SM00635'], ['MOBIDB_LITE', 'mobidb-lite'], ['SUPERFAMILY', 'SSF49785']], 'ADB80105.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PROSITE_PROFILES', 'PS51257'], ['SIGNALP_EUK', 'SignalP-noTM']], 'CAZ94303.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'G3DSA:3.20.20.80'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'SSF51445'], ['PROSITE_PROFILES', 'PS51257'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM']], 'CBK67650.1': [['GENE3D', 'G3DSA:3.20.20.80'], ['PRINTS', 'PR00743'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['CDD', 'cd14791'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PANTHER', 'PTHR42767'], ['GENE3D', 'G3DSA:2.70.98.60'], ['SUPERFAMILY', 'SSF51445'], ['SUPERFAMILY', 'SSF51445'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PRINTS', 'PR00743'], ['PFAM', 'PF02065'], ['PRINTS', 'PR00743'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'G3DSA:3.20.20.70'], ['GENE3D', 'G3DSA:2.60.40.1180']]}\n"
     ]
    }
   ],
   "source": [
    "#API url\n",
    "URL = \"https://www.ebi.ac.uk/interpro/match-lookup/matches\"\n",
    "\n",
    "#Here we generate a file only containing UNIQUE sequences that can be used for InterPro domain detection\n",
    "def prep_input(inputfastafile, charblastdict, outputblastdict):\n",
    "    \"\"\"This function parses trough a given FASTA file and creates a dict of ID: sequence\"\"\"\n",
    "    proteins = {}\n",
    "    \n",
    "    with open(inputfastafile,'r') as f:\n",
    "        for seq_record in SeqIO.parse(f, 'fasta'):\n",
    "            seq_id = seq_record.id[:seq_record.id.find('_')]\n",
    "            \n",
    "            #if we did a BLAST search for characterized proteins, we'll use the sequence of the result\n",
    "            if seq_id in charblastdict:\n",
    "                proteins[seq_id] = outputblastdict[charblastdict[seq_id]]\n",
    "            else:\n",
    "                proteins[seq_id] = str(seq_record.seq)\n",
    "    \n",
    "    return proteins\n",
    "\n",
    "def domain_detection(inputfastafile, charblastdict, outputblastdict):\n",
    "    \"\"\"This function uses the InterPro API and returns the domains that can be found in several databases\"\"\"\n",
    "    \n",
    "    md5_to_id = {}\n",
    "    \n",
    "    domainoutput = {}\n",
    "    positionoutput = {}\n",
    "    databaseoutput = {}\n",
    "    \n",
    "    #create a dictionary of ID:sequence\n",
    "    \n",
    "    proteins = prep_input(inputfastafile, blastchar[0], blastchar[1])\n",
    "    #converts the protein sequences to a hexadecimal representation in uppercase\n",
    "    for identifier, sequence in proteins.items():\n",
    "        md5 = hashlib.md5(sequence.encode()).hexdigest().upper()\n",
    "        md5_to_id[md5] = identifier\n",
    "    \n",
    "        \n",
    "    #print(md5_to_id)\n",
    "    params = {\"md5\": list(md5_to_id.keys())}\n",
    "    #print(params)\n",
    "    data = urlencode(params, doseq=True).encode(\"ascii\")\n",
    "    #print(data)\n",
    "    \n",
    "    try:\n",
    "\n",
    "        with urlopen(URL, data) as res:\n",
    "            data = res.read().decode(\"utf-8\")\n",
    "\n",
    "    except HTTPError as err:\n",
    "          print(f\"HTTP error occured: {err}\")\n",
    "            \n",
    "    domain_ids = []\n",
    "    unknown_ids = []\n",
    "    \n",
    "\n",
    "    root = ET.fromstring(data)\n",
    "    for m in root.findall(\".//match\"):\n",
    "        md5 = m.find(\"proteinMD5\").text\n",
    "        protein_id = md5_to_id.pop(md5) #ID's of proteins that have a UniParc Identifier\n",
    "        domain_ids.append(protein_id)\n",
    "        \n",
    "        #print(protein_id)\n",
    "        domaindictionary = {}\n",
    "        positionlist = []\n",
    "        databaselist = []\n",
    "        \n",
    "        #find domains on InterPro\n",
    "        for hit in m.findall(\"hit\"):\n",
    "\n",
    "            #print(hit)\n",
    "            columns = hit.text.split(\",\")\n",
    "            \n",
    "            fragments = []\n",
    "            for frag in columns[6].split(\";\"):\n",
    "                start, end, _ = frag.split(\"-\")\n",
    "                fragments.append((int(start), int(end)))\n",
    "            \n",
    "                \n",
    "                domaindatabase = columns[0]\n",
    "                domainname = columns[2]\n",
    "                domainstart = fragments[0][0]\n",
    "                domainend = fragments[0][1]\n",
    "            \n",
    "            domaindictionary[str([domainstart, domainend])] = domainname\n",
    "            positionlist.append([domainstart, domainend])\n",
    "            databaselist.append([domaindatabase, domainname])\n",
    "            \n",
    "\n",
    "        domainoutput[protein_id] = domaindictionary\n",
    "        positionoutput[protein_id] = positionlist\n",
    "        databaseoutput[protein_id] = databaselist\n",
    "\n",
    "    \n",
    "    for protein_id in md5_to_id.values():\n",
    "        unknown_ids.append(protein_id)\n",
    "        \n",
    "        sys.stderr.write(f\"No domains found in {protein_id}:\"f\" try to run InterProScan\\n\")\n",
    "        \n",
    "    print(domainoutput)\n",
    "    print(domainoutput.keys())\n",
    "    print('\\n')\n",
    "    print(positionoutput)\n",
    "    print('\\n')\n",
    "    print(databaseoutput)\n",
    "    \n",
    "    return domainoutput, positionoutput, databaseoutput\n",
    "\n",
    "\n",
    "if go == True:\n",
    "    #inputfile\n",
    "    fastaseq = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_inclchar.fasta\")\n",
    "    #fetch the domains\n",
    "    finddomains = domain_detection(fastaseq, blastchar[0], blastchar[1])\n",
    "    \n",
    "else:\n",
    "    #when using an own input FASTA file\n",
    "    fastaseq = inputfile_path\n",
    "    blastchar = [{},{},[]]\n",
    "    finddomains = domain_detection(fastaseq, blastchar[0], blastchar[1])\n",
    "    "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 67,
   "id": "386eeb0d",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import packages\n",
    "from operator import itemgetter\n",
    "# standard library modules\n",
    "import sys, errno, re, json, ssl\n",
    "import urllib\n",
    "from urllib import request\n",
    "from urllib.error import HTTPError\n",
    "from urllib.error import URLError\n",
    "from time import sleep\n",
    "import itertools"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 68,
   "id": "75354a55",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fetching the corresponding names for all domains.\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "100%|███████████████████████████████████████████| 69/69 [00:53<00:00,  1.28it/s]"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ATO84721.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases']], 'BBL06275.1': [['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases']], 'BBL01040.1': [['PFAM', 'Cellulase (glycosyl hydrolase family 5)'], ['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases']], 'UWN65549.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['GENE3D', 'Glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['MOBIDB_LITE', 'mobidb-lite'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'CBK63196.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'UZO80939.1': [['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PFAM', 'Cellulase (glycosyl hydrolase family 5)'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile']], 'UZO80937.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'Cellulase (glycosyl hydrolase family 5)']], 'AGY53053.1': [['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Glycosidases'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', '(Trans)glycosidases']], 'ANU59401.1': [['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM']], 'ANU59398.1': [['GENE3D', 'alpha-galactosidase from lactobacil brevis'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PRINTS', 'None'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['PFAM', 'Melibiase'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Glycosidases'], ['CDD', 'glycosyl hydrolase family 36 (GH36)'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'Aldolase class I'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PRINTS', 'None'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PRINTS', 'None'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'UBD71149.1': [['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'QUT88730.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'UWN88717.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM']], 'UVR10658.1': [['GENE3D', 'Aldolase class I'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PFAM', 'Melibiase'], ['PRINTS', 'None'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['PRINTS', 'None'], ['GENE3D', 'Glycosidases'], ['GENE3D', 'alpha-galactosidase from lactobacil brevis'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PRINTS', 'None'], ['CDD', 'glycosyl hydrolase family 36 (GH36)']], 'UVO70767.1': [['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE']], 'UVO70768.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM']], 'QGT72561.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile']], 'UWO00929.1': [['PFAM', 'Cellulase (glycosyl hydrolase family 5)'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'UWO00930.1': [['GENE3D', 'Glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', '(Trans)glycosidases']], 'UVR93289.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'QZU84679.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'CBK67267.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'QEG33916.1': [['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases']], 'ABP68096.1': [['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PFAM', 'Cellulase (glycosyl hydrolase family 5)'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['TMHMM', 'TMhelix'], ['PANTHER', 'Blood Group Antigen-Binding Lectin'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PFAM', 'F5/8 type C domain'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'Glycosidases'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PROSITE_PROFILES', 'Coagulation factors 5/8 type C domain (FA58C) profile'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM']], 'BDI31947.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-TM'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN']], 'ADV49313.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'Glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION']], 'ADV49311.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'APU67655.1': [['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'Cellulase (glycosyl hydrolase family 5)'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'APU67659.1': [['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Glycosidases']], 'WLC65246.1': [['TMHMM', 'TMhelix'], ['SUPERFAMILY', '(Trans)glycosidases'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'TRANSMEMBRANE'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'TRANSMEMBRANE'], ['GENE3D', 'Glycosidases']], 'QTH43817.1': [['GENE3D', 'Glycosidases'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'Fibronectin type III'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['CDD', 'None'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_EUK', 'SignalP-TM'], ['GENE3D', 'Immunoglobulins'], ['PROSITE_PROFILES', 'Fibronectin type-III domain profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PFAM', 'Carbohydrate binding domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PFAM', 'Carbohydrate binding domain']], 'QHS51394.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PFAM', 'Glycosyl hydrolase family 26'], ['PRINTS', 'None'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PRINTS', 'None'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PRINTS', 'None'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PRINTS', 'None'], ['PROSITE_PROFILES', 'Glycosyl hydrolases family 26 (GH26) domain profile'], ['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PANTHER', 'MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED']], 'QWG05959.1': [['GENE3D', 'Glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', '(Trans)glycosidases']], 'ANQ50808.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases']], 'QWG01382.1': [['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'UII20690.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN']], 'UII20686.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases']], 'WPO86937.1': [['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PFAM', 'HpiC1 cyclase'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PROSITE_PROFILES', 'Twin arginine translocation (Tat) signal profile'], ['TMHMM', 'TMhelix']], 'WPO86936.1': [['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'WEV39865.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['GENE3D', 'Glycosidases']], 'QHO70380.1': [['GENE3D', 'Golgi alpha-mannosidase II'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Galactose-binding domain-like']], 'APF34734.1': [['GENE3D', 'Immunoglobulins'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'BAJ75160.1': [['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PROSITE_PROFILES', 'Twin arginine translocation (Tat) signal profile'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases']], 'BAJ74095.1': [['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PROSITE_PROFILES', 'Twin arginine translocation (Tat) signal profile'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases']], 'AHF17862.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'AHF89993.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Glycosidases'], ['MOBIDB_LITE', 'mobidb-lite'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['TMHMM', 'TMhelix']], 'AHF91408.1': [['MOBIDB_LITE', 'mobidb-lite'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases']], 'WFR61027.1': [['GENE3D', 'Glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['TMHMM', 'TMhelix'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_EUK', 'SignalP-noTM']], 'ANF97338.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['GENE3D', 'Glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_EUK', 'SignalP-noTM'], ['TMHMM', 'TMhelix'], ['PFAM', 'Glycosyl hydrolase catalytic core'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'WPP43235.1': [['MOBIDB_LITE', 'mobidb-lite'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PFAM', 'Glycosyl hydrolase catalytic core'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['MOBIDB_LITE', 'mobidb-lite'], ['MOBIDB_LITE', 'mobidb-lite'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['MOBIDB_LITE', 'mobidb-lite'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['MOBIDB_LITE', 'mobidb-lite']], 'ANY71428.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PFAM', 'Glycosyl hydrolase catalytic core'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain']], 'WCT54208.1': [['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'Galactose-binding domain-like'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['TMHMM', 'TMhelix']], 'AYB42811.1': [['GENE3D', 'Glycosidases'], ['SUPERFAMILY', 'Fibronectin type III'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PROSITE_PROFILES', 'Fibronectin type-III domain profile'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PFAM', 'Glycosyl hydrolase catalytic core'], ['GENE3D', 'Immunoglobulins'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['TMHMM', 'TMhelix'], ['SUPERFAMILY', '(Trans)glycosidases'], ['CDD', 'None']], 'QGG55106.1': [['PFAM', 'F5/8 type C domain'], ['MOBIDB_LITE', 'mobidb-lite'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'Glycosidases'], ['GENE3D', 'Galactose-binding domain-like'], ['PROSITE_PROFILES', 'Coagulation factors 5/8 type C domain (FA58C) profile'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['SUPERFAMILY', '(Trans)glycosidases'], ['MOBIDB_LITE', 'mobidb-lite']], 'WJH29034.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PROSITE_PROFILES', 'CBM6 (carbohydrate binding type-6) domain profile'], ['GENE3D', 'Glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Galactose-binding domain-like'], ['TMHMM', 'TMhelix'], ['GENE3D', 'Galactose-binding domain-like'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Galactose-binding domain-like']], 'QNK55806.1': [['SUPERFAMILY', 'Fibronectin type III'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['GENE3D', 'Immunoglobulins'], ['SUPERFAMILY', 'Glycosyl hydrolase domain'], ['PFAM', 'Carbohydrate binding domain'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Glycosidases'], ['GENE3D', 'Galactose-binding domain-like'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PROSITE_PROFILES', 'Fibronectin type-III domain profile'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PFAM', 'Carbohydrate binding domain'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['MOBIDB_LITE', 'mobidb-lite'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['TMHMM', 'TMhelix'], ['PFAM', 'Carbohydrate binding domain'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM']], 'QNK57010.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'Galactose-binding domain-like'], ['GENE3D', 'Glycosidases'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['GENE3D', 'Galactose-binding domain-like'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['PFAM', 'Glycosyl hydrolase catalytic core'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'QNK57015.1': [['PFAM', 'Cohesin domain'], ['GENE3D', 'Glycosidases'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain'], ['MOBIDB_LITE', 'mobidb-lite'], ['GENE3D', 'Galactose-binding domain-like'], ['PFAM', 'FIVAR domain'], ['GENE3D', 'Dockerin domain'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PFAM', 'Glycosyl hydrolase catalytic core'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'AF1782-like'], ['PFAM', 'FIVAR domain'], ['GENE3D', 'AF1782-like'], ['GENE3D', 'None'], ['SUPERFAMILY', 'Carbohydrate-binding domain'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['CDD', 'Type II cohesin domain, interaction partner of dockerin'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN']], 'WMJ22082.1': [['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Golgi alpha-mannosidase II']], 'UVQ47681.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['PRINTS', 'None'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PRINTS', 'None'], ['CDD', 'glycosyl hydrolase family 36 (GH36)'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['GENE3D', 'alpha-galactosidase from lactobacil brevis'], ['GENE3D', 'Aldolase class I'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PRINTS', 'None'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PRINTS', 'None'], ['PFAM', 'Melibiase'], ['GENE3D', 'Glycosidases']], 'BDD02170.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_EUK', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SUPERFAMILY', '(Trans)glycosidases']], 'BDD02164.1': [['GENE3D', 'Glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'Golgi alpha-mannosidase II'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PFAM', 'Cellulase (glycosyl hydrolase family 5)'], ['PHOBIUS', 'SIGNAL_PEPTIDE']], 'AGB28643.1': [['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['TMHMM', 'TMhelix'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['GENE3D', 'Glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION']], 'AGB28629.1': [['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases'], ['GENE3D', 'Aldolase class I'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['GENE3D', 'Glycosidases'], ['PFAM', 'Melibiase'], ['GENE3D', 'alpha-galactosidase from lactobacil brevis'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION']], 'QMW75430.1': [['GENE3D', 'Galactose-binding domain-like'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['TMHMM', 'TMhelix'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PFAM', 'Carbohydrate binding domain'], ['TMHMM', 'TMhelix'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'TRANSMEMBRANE'], ['PFAM', 'Carbohydrate binding domain'], ['SIGNALP_EUK', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['COILS', 'Coil'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['SUPERFAMILY', 'Galactose-binding domain-like'], ['SUPERFAMILY', 'Galactose-binding domain-like']], 'QQV06122.1': [['SMART', 'Bacterial Ig-like domain 2'], ['COILS', 'Coil'], ['COILS', 'Coil'], ['COILS', 'Coil'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SMART', 'Bacterial Ig-like domain 2'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['GENE3D', 'Galactose-binding domain-like'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['TMHMM', 'TMhelix'], ['PFAM', 'F5/8 type C domain'], ['SMART', 'Bacterial Ig-like domain 2'], ['GENE3D', 'AF1782-like'], ['GENE3D', 'None'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['MOBIDB_LITE', 'mobidb-lite'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', 'Invasin/intimin cell-adhesion fragments'], ['PFAM', 'Bacterial Ig-like domain (group 2)'], ['GENE3D', 'None'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PFAM', 'Bacterial Ig-like domain (group 2)'], ['GENE3D', 'AF1782-like'], ['PHOBIUS', 'CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'TRANSMEMBRANE'], ['TMHMM', 'TMhelix'], ['COILS', 'Coil'], ['GENE3D', 'None'], ['SUPERFAMILY', 'Invasin/intimin cell-adhesion fragments'], ['PROSITE_PROFILES', 'Coagulation factors 5/8 type C domain (FA58C) profile'], ['COILS', 'Coil'], ['SIGNALP_EUK', 'SignalP-noTM'], ['SMART', 'Bacterial Ig-like domain 2'], ['MOBIDB_LITE', 'mobidb-lite'], ['SUPERFAMILY', 'Galactose-binding domain-like']], 'ADB80105.1': [['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['GENE3D', 'Glycosidases'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['SIGNALP_EUK', 'SignalP-noTM']], 'CAZ94303.1': [['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['GENE3D', 'Glycosidases'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PROSITE_PROFILES', 'Prokaryotic membrane lipoprotein lipid attachment site profile'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['SIGNALP_GRAM_POSITIVE', 'SignalP-TM']], 'CBK67650.1': [['GENE3D', 'Glycosidases'], ['PRINTS', 'None'], ['PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION'], ['PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION'], ['CDD', 'glycosyl hydrolase family 36 (GH36)'], ['SIGNALP_GRAM_NEGATIVE', 'SignalP-noTM'], ['PANTHER', 'ENDO-BETA-1,6-GALACTANASE'], ['GENE3D', 'alpha-galactosidase from lactobacil brevis'], ['SUPERFAMILY', '(Trans)glycosidases'], ['SUPERFAMILY', '(Trans)glycosidases'], ['PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN'], ['PHOBIUS', 'SIGNAL_PEPTIDE'], ['PRINTS', 'None'], ['PFAM', 'Melibiase'], ['PRINTS', 'None'], ['SIGNALP_EUK', 'SignalP-noTM'], ['PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION'], ['GENE3D', 'Aldolase class I'], ['GENE3D', 'Golgi alpha-mannosidase II']]}\n",
      "{'ATO84721.1': {'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'BBL06275.1': {'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY'}, 'BBL01040.1': {'Cellulase (glycosyl hydrolase family 5)': 'PFAM', 'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY'}, 'UWN65549.1': {'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'Glycosidases': 'GENE3D', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'mobidb-lite': 'MOBIDB_LITE', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS'}, 'CBK63196.1': {'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS'}, 'UZO80939.1': {'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'Cellulase (glycosyl hydrolase family 5)': 'PFAM', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES'}, 'UZO80937.1': {'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Cellulase (glycosyl hydrolase family 5)': 'PFAM'}, 'AGY53053.1': {'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'TMhelix': 'TMHMM', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'ANU59401.1': {'(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE'}, 'ANU59398.1': {'alpha-galactosidase from lactobacil brevis': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'None': 'PRINTS', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'Melibiase': 'PFAM', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'glycosyl hydrolase family 36 (GH36)': 'CDD', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Aldolase class I': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS'}, 'UBD71149.1': {'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS'}, 'QUT88730.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'Glycosidases': 'GENE3D', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'UWN88717.1': {'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS'}, 'UVR10658.1': {'Aldolase class I': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'Golgi alpha-mannosidase II': 'GENE3D', 'Melibiase': 'PFAM', 'None': 'PRINTS', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'Glycosidases': 'GENE3D', 'alpha-galactosidase from lactobacil brevis': 'GENE3D', 'glycosyl hydrolase family 36 (GH36)': 'CDD'}, 'UVO70767.1': {'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER'}, 'UVO70768.1': {'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS'}, 'QGT72561.1': {'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosidases': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES'}, 'UWO00929.1': {'Cellulase (glycosyl hydrolase family 5)': 'PFAM', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS'}, 'UWO00930.1': {'Glycosidases': 'GENE3D', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'UVR93289.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS'}, 'QZU84679.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'CBK67267.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SignalP-noTM': 'SIGNALP_EUK', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS'}, 'QEG33916.1': {'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY'}, 'ABP68096.1': {'Galactose-binding domain-like': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Cellulase (glycosyl hydrolase family 5)': 'PFAM', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'TMhelix': 'TMHMM', 'Blood Group Antigen-Binding Lectin': 'PANTHER', '(Trans)glycosidases': 'SUPERFAMILY', 'F5/8 type C domain': 'PFAM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'Golgi alpha-mannosidase II': 'GENE3D', 'Coagulation factors 5/8 type C domain (FA58C) profile': 'PROSITE_PROFILES', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE'}, 'BDI31947.1': {'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS'}, 'ADV49313.1': {'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Golgi alpha-mannosidase II': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS'}, 'ADV49311.1': {'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'APU67655.1': {'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Cellulase (glycosyl hydrolase family 5)': 'PFAM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SignalP-noTM': 'SIGNALP_EUK', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS'}, 'APU67659.1': {'(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'TMhelix': 'TMHMM', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D'}, 'WLC65246.1': {'TMhelix': 'TMHMM', '(Trans)glycosidases': 'SUPERFAMILY', 'CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'TRANSMEMBRANE': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Glycosidases': 'GENE3D'}, 'QTH43817.1': {'Glycosidases': 'GENE3D', 'Galactose-binding domain-like': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Fibronectin type III': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'None': 'CDD', 'SignalP-TM': 'SIGNALP_EUK', 'Immunoglobulins': 'GENE3D', 'Fibronectin type-III domain profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'Carbohydrate binding domain': 'PFAM', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Golgi alpha-mannosidase II': 'GENE3D'}, 'QHS51394.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'Glycosidases': 'GENE3D', 'Glycosyl hydrolase family 26': 'PFAM', 'None': 'PRINTS', '(Trans)glycosidases': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Glycosyl hydrolases family 26 (GH26) domain profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED': 'PANTHER'}, 'QWG05959.1': {'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'ANQ50808.1': {'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', '(Trans)glycosidases': 'SUPERFAMILY'}, 'QWG01382.1': {'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS'}, 'UII20690.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosidases': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS'}, 'UII20686.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', '(Trans)glycosidases': 'SUPERFAMILY'}, 'WPO86937.1': {'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Galactose-binding domain-like': 'SUPERFAMILY', '(Trans)glycosidases': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'HpiC1 cyclase': 'PFAM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Twin arginine translocation (Tat) signal profile': 'PROSITE_PROFILES', 'TMhelix': 'TMHMM'}, 'WPO86936.1': {'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'WEV39865.1': {'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'TMhelix': 'TMHMM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Glycosidases': 'GENE3D'}, 'QHO70380.1': {'Golgi alpha-mannosidase II': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY'}, 'APF34734.1': {'Immunoglobulins': 'GENE3D', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'TMhelix': 'TMHMM', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', '(Trans)glycosidases': 'SUPERFAMILY', 'Galactose-binding domain-like': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'BAJ75160.1': {'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'GENE3D', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Twin arginine translocation (Tat) signal profile': 'PROSITE_PROFILES', 'Glycosidases': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'BAJ74095.1': {'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Galactose-binding domain-like': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Twin arginine translocation (Tat) signal profile': 'PROSITE_PROFILES', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'TMhelix': 'TMHMM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'AHF17862.1': {'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'AHF89993.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'mobidb-lite': 'MOBIDB_LITE', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'TMhelix': 'TMHMM'}, 'AHF91408.1': {'mobidb-lite': 'MOBIDB_LITE', 'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY'}, 'WFR61027.1': {'Glycosidases': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'TMhelix': 'TMHMM', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SignalP-noTM': 'SIGNALP_EUK'}, 'ANF97338.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'mobidb-lite': 'MOBIDB_LITE', 'Galactose-binding domain-like': 'GENE3D', 'TMhelix': 'TMHMM', 'Glycosyl hydrolase catalytic core': 'PFAM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS'}, 'WPP43235.1': {'mobidb-lite': 'MOBIDB_LITE', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosyl hydrolase catalytic core': 'PFAM', 'Galactose-binding domain-like': 'GENE3D', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'TMhelix': 'TMHMM', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS'}, 'ANY71428.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosidases': 'GENE3D', 'Glycosyl hydrolase catalytic core': 'PFAM', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM'}, 'WCT54208.1': {'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'Galactose-binding domain-like': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'TMhelix': 'TMHMM'}, 'AYB42811.1': {'Glycosidases': 'GENE3D', 'Fibronectin type III': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Fibronectin type-III domain profile': 'PROSITE_PROFILES', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'Glycosyl hydrolase catalytic core': 'PFAM', 'Immunoglobulins': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'TMhelix': 'TMHMM', '(Trans)glycosidases': 'SUPERFAMILY', 'None': 'CDD'}, 'QGG55106.1': {'F5/8 type C domain': 'PFAM', 'mobidb-lite': 'MOBIDB_LITE', 'Glycosidases': 'GENE3D', 'Galactose-binding domain-like': 'SUPERFAMILY', 'Coagulation factors 5/8 type C domain (FA58C) profile': 'PROSITE_PROFILES', '(Trans)glycosidases': 'SUPERFAMILY'}, 'WJH29034.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'CBM6 (carbohydrate binding type-6) domain profile': 'PROSITE_PROFILES', 'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'TMhelix': 'TMHMM', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS'}, 'QNK55806.1': {'Fibronectin type III': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'GENE3D', 'Immunoglobulins': 'GENE3D', 'Glycosyl hydrolase domain': 'SUPERFAMILY', 'Carbohydrate binding domain': 'PFAM', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'Golgi alpha-mannosidase II': 'GENE3D', 'Fibronectin type-III domain profile': 'PROSITE_PROFILES', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'mobidb-lite': 'MOBIDB_LITE', 'SignalP-noTM': 'SIGNALP_GRAM_NEGATIVE', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'TMhelix': 'TMHMM', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', '(Trans)glycosidases': 'SUPERFAMILY'}, 'QNK57010.1': {'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Galactose-binding domain-like': 'SUPERFAMILY', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'TMhelix': 'TMHMM', 'Glycosyl hydrolase catalytic core': 'PFAM', '(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS'}, 'QNK57015.1': {'Cohesin domain': 'PFAM', 'Glycosidases': 'GENE3D', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Galactose-binding domain-like': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Chitobiase/beta-hexosaminidase C-terminal domain': 'PFAM', 'mobidb-lite': 'MOBIDB_LITE', 'FIVAR domain': 'PFAM', 'Dockerin domain': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'Glycosyl hydrolase catalytic core': 'PFAM', 'SignalP-noTM': 'SIGNALP_EUK', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'AF1782-like': 'GENE3D', 'None': 'GENE3D', 'Carbohydrate-binding domain': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Type II cohesin domain, interaction partner of dockerin': 'CDD', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS'}, 'WMJ22082.1': {'(Trans)glycosidases': 'SUPERFAMILY', 'Golgi alpha-mannosidase II': 'GENE3D'}, 'UVQ47681.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'TMhelix': 'TMHMM', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'None': 'PRINTS', '(Trans)glycosidases': 'SUPERFAMILY', 'glycosyl hydrolase family 36 (GH36)': 'CDD', 'Golgi alpha-mannosidase II': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'alpha-galactosidase from lactobacil brevis': 'GENE3D', 'Aldolase class I': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Melibiase': 'PFAM', 'Glycosidases': 'GENE3D'}, 'BDD02170.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY'}, 'BDD02164.1': {'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Golgi alpha-mannosidase II': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Cellulase (glycosyl hydrolase family 5)': 'PFAM', 'SIGNAL_PEPTIDE': 'PHOBIUS'}, 'AGB28643.1': {'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'TMhelix': 'TMHMM', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'SignalP-noTM': 'SIGNALP_EUK', '(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS'}, 'AGB28629.1': {'(Trans)glycosidases': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Aldolase class I': 'GENE3D', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SignalP-noTM': 'SIGNALP_EUK', 'Glycosidases': 'GENE3D', 'Melibiase': 'PFAM', 'alpha-galactosidase from lactobacil brevis': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS'}, 'QMW75430.1': {'Galactose-binding domain-like': 'SUPERFAMILY', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'TMhelix': 'TMHMM', 'CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Carbohydrate binding domain': 'PFAM', '(Trans)glycosidases': 'SUPERFAMILY', 'SignalP-TM': 'SIGNALP_EUK', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'TRANSMEMBRANE': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Coil': 'COILS'}, 'QQV06122.1': {'Bacterial Ig-like domain 2': 'SMART', 'Coil': 'COILS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'Galactose-binding domain-like': 'SUPERFAMILY', '(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'TMhelix': 'TMHMM', 'F5/8 type C domain': 'PFAM', 'AF1782-like': 'GENE3D', 'None': 'GENE3D', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'mobidb-lite': 'MOBIDB_LITE', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Invasin/intimin cell-adhesion fragments': 'SUPERFAMILY', 'Bacterial Ig-like domain (group 2)': 'PFAM', 'SignalP-noTM': 'SIGNALP_EUK', 'CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'TRANSMEMBRANE': 'PHOBIUS', 'Coagulation factors 5/8 type C domain (FA58C) profile': 'PROSITE_PROFILES'}, 'ADB80105.1': {'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SignalP-noTM': 'SIGNALP_EUK', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES'}, 'CAZ94303.1': {'SignalP-noTM': 'SIGNALP_EUK', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'Glycosidases': 'GENE3D', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', '(Trans)glycosidases': 'SUPERFAMILY', 'Prokaryotic membrane lipoprotein lipid attachment site profile': 'PROSITE_PROFILES', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'SignalP-TM': 'SIGNALP_GRAM_POSITIVE'}, 'CBK67650.1': {'Glycosidases': 'GENE3D', 'None': 'PRINTS', 'SIGNAL_PEPTIDE_N_REGION': 'PHOBIUS', 'SIGNAL_PEPTIDE_H_REGION': 'PHOBIUS', 'glycosyl hydrolase family 36 (GH36)': 'CDD', 'SignalP-noTM': 'SIGNALP_EUK', 'ENDO-BETA-1,6-GALACTANASE': 'PANTHER', 'alpha-galactosidase from lactobacil brevis': 'GENE3D', '(Trans)glycosidases': 'SUPERFAMILY', 'NON_CYTOPLASMIC_DOMAIN': 'PHOBIUS', 'SIGNAL_PEPTIDE': 'PHOBIUS', 'Melibiase': 'PFAM', 'SIGNAL_PEPTIDE_C_REGION': 'PHOBIUS', 'Aldolase class I': 'GENE3D', 'Golgi alpha-mannosidase II': 'GENE3D'}}\n",
      "Finished!\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "\n"
     ]
    }
   ],
   "source": [
    "def get_domain_name(databaseoutput):\n",
    "    \"\"\"This function retrieves the appropriate name for each found domain. it converts the InterPro ID to the corresponding name\"\"\"\n",
    "    \n",
    "    ROOTURL = 'https://www.ebi.ac.uk/interpro/api/entry/'\n",
    "    entryDB = {'GENE3D':'cathgene3d', 'CDD':'cdd', 'HAMAP':'hamap', 'PANTHER':'panther', 'PFAM':'pfam', 'PIRSF':'pirsf', 'PRINTS':'prints', 'PROSITE_PROFILES':'profile', 'PROSITE_PATTERNS':'prosite', 'SFLD':'sfld', 'SMART':'smart', 'SUPERFAMILY':'ssf', 'TIGRFAMS':'tigrfams', 'NCBIfam':'ncbifam'}\n",
    "    \n",
    "    #output\n",
    "    domainnamelist = {}\n",
    "    domainnamedictionary = {}\n",
    "    \n",
    "    #let's speed up the proces by creating a dictionary: 'domain code': 'domain name'\n",
    "    domaincode_name_dict = {}\n",
    "    \n",
    "    total_length = len(databaseoutput)\n",
    "    for key, value in tqdm(databaseoutput.items(), total = total_length):\n",
    "        templist = []\n",
    "        tempdict = {}\n",
    "        \n",
    "        for domain in value:\n",
    "            \n",
    "        #database = domain[0]\n",
    "        #domain code = domain[1]\n",
    "        \n",
    "            #first, check if the domain code is already present in the domaincode_name_dict, if so fetch the name\n",
    "            if domain[1] in domaincode_name_dict:\n",
    "                #fetch the name\n",
    "                name = domaincode_name_dict[domain[1]]\n",
    "                    \n",
    "                #add the name to a dictionary and list\n",
    "                tempdict[name] = domain[0]  \n",
    "                templist.append([domain[0], name])\n",
    "                \n",
    "            #if this domain code is not yet present in domaincode_name_dict, use the API to fetch and append it     \n",
    "            else:\n",
    "        \n",
    "                if domain[0] in entryDB:\n",
    "\n",
    "                    #disable SSL verification to avoid config issues\n",
    "                    context = ssl._create_unverified_context()\n",
    "\n",
    "                    next = ROOTURL + entryDB[domain[0]] + '/' + domain[1]\n",
    "                    last_page = False\n",
    "                    attempts = 0\n",
    "\n",
    "                    while next:\n",
    "                        try:\n",
    "\n",
    "                            req = request.Request(next, headers={\"Accept\": \"application/json\"})\n",
    "                            res = request.urlopen(req, context=context)\n",
    "                            # If the API times out due a long running query\n",
    "                            if res.status == 408:\n",
    "                            # wait just over a minute\n",
    "                                sleep(61)\n",
    "                            # then continue this loop with the same URL\n",
    "                                continue\n",
    "\n",
    "                            elif res.status == 204:\n",
    "                                print('sorry no data could be retrieved for this entry' + '\\n')\n",
    "                                break\n",
    "\n",
    "                            elif res.status == 404:\n",
    "                                print('sorry no data could be retrieved for this entry' + '\\n')\n",
    "                                break\n",
    "\n",
    "                            payload = json.loads(res.read().decode())\n",
    "                            attempts = 0\n",
    "\n",
    "                            last_page = True\n",
    "                            next = False #needed to avoid loop\n",
    "\n",
    "                        except HTTPError as e:\n",
    "                            if e.code == 408:\n",
    "                                sleep(61)\n",
    "                                continue\n",
    "                            else:\n",
    "                                #If there is a different HTTP error, it wil re-try 3 times before failing\n",
    "                                if attempts < 3:\n",
    "                                    attempts += 1\n",
    "                                    sleep(61)\n",
    "                                    continue\n",
    "                                else:\n",
    "                                    sys.stderr.write(\"LAST URL: \" + next)\n",
    "                                    raise e\n",
    "\n",
    "                        except urllib.error.URLError as e:\n",
    "                            if attempts < 3:\n",
    "                                attempts += 1\n",
    "                                sleep(61)\n",
    "                                continue\n",
    "                            else:\n",
    "                                raise e\n",
    "\n",
    "                        #fetch the name\n",
    "                        name = str(payload['metadata']['name']['name'])\n",
    "\n",
    "                        #add the name to a dictionary and list\n",
    "                        tempdict[name] = domain[0]  \n",
    "                        templist.append([domain[0], name])\n",
    "                        \n",
    "                        #add the name to domaincode_name_dict to speed up the proces\n",
    "                        domaincode_name_dict[domain[1]] = name\n",
    "\n",
    "                        if next:\n",
    "                            sleep(1)\n",
    "                    sleep(1)\n",
    "\n",
    "                else:\n",
    "\n",
    "                    tempdict[domain[1]] = domain[0]\n",
    "                    templist.append(domain)\n",
    "        \n",
    "        #create a dictionary that has the identifiers as keys and a list of lists containing the database and domain names for every found domain as values\n",
    "        domainnamedictionary[key] = tempdict\n",
    "        \n",
    "        #create a dictionary that has the identifiers as keys and a dictionary containing the names and the databases it was fetched from, as values\n",
    "        domainnamelist[key] = templist\n",
    "        \n",
    "    print(domainnamelist)\n",
    "    print(domainnamedictionary)\n",
    "    \n",
    "    return domainnamelist, domainnamedictionary\n",
    "\n",
    "#find the domain names for every protein\n",
    "print('Fetching the corresponding names for all domains.')\n",
    "finddomainnames = get_domain_name(finddomains[2])\n",
    "\n",
    "#save this output in case the script gets interrupted later\n",
    "with open(os.path.join(jobname, f\"domainnamelist.fasta\"), 'w') as file:\n",
    "    file.write(str(finddomainnames[0]))\n",
    "    \n",
    "with open(os.path.join(jobname, f\"domainnamedictionary.fasta\"), 'w') as file:\n",
    "    file.write(str(finddomainnames[1]))  \n",
    "    \n",
    "print('Finished!')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 69,
   "id": "5de07684",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ATO84721.1': {'[5, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 26]': 'SignalP-TM', '[19, 26]': 'SIGNAL_PEPTIDE_C_REGION', '[27, 620]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 18]': 'SignalP-noTM', '[333, 503]': 'Glycosidases', '[358, 495]': '(Trans)glycosidases'}, 'BBL06275.1': {'[86, 340]': 'Glycosidases', '[4, 240]': '(Trans)glycosidases'}, 'BBL01040.1': {'[15, 251]': 'Cellulase (glycosyl hydrolase family 5)', '[22, 352]': 'Glycosidases', '[30, 348]': '(Trans)glycosidases'}, 'UWN65549.1': {'[1, 25]': 'SignalP-TM', '[26, 526]': 'NON_CYTOPLASMIC_DOMAIN', '[125, 430]': '(Trans)glycosidases', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[189, 523]': 'ENDO-BETA-1,6-GALACTANASE', '[97, 430]': 'Glycosidases', '[1, 20]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[26, 45]': 'mobidb-lite', '[9, 20]': 'SIGNAL_PEPTIDE_H_REGION', '[21, 25]': 'SIGNAL_PEPTIDE_C_REGION'}, 'CBK63196.1': {'[1, 20]': 'SignalP-noTM', '[59, 384]': 'Glycosidases', '[7, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[21, 493]': 'NON_CYTOPLASMIC_DOMAIN', '[47, 381]': '(Trans)glycosidases', '[17, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 21]': 'SignalP-noTM', '[1, 19]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'UZO80939.1': {'[24, 506]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 30]': 'SignalP-TM', '[19, 23]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 23]': 'SIGNAL_PEPTIDE', '[45, 306]': 'Glycosidases', '[10, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[75, 373]': '(Trans)glycosidases', '[53, 300]': 'Cellulase (glycosyl hydrolase family 5)', '[1, 22]': 'SignalP-noTM'}, 'UZO80937.1': {'[5, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[21, 521]': 'NON_CYTOPLASMIC_DOMAIN', '[89, 353]': 'Glycosidases', '[70, 314]': '(Trans)glycosidases', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 20]': 'SignalP-noTM', '[17, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 24]': 'SignalP-TM', '[74, 317]': 'Cellulase (glycosyl hydrolase family 5)'}, 'AGY53053.1': {'[1, 22]': 'SignalP-noTM', '[5, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[31, 377]': 'Glycosidases', '[1, 24]': 'SignalP-TM', '[5, 27]': 'TMhelix', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[23, 489]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 18]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[17, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[57, 284]': '(Trans)glycosidases'}, 'ANU59401.1': {'[181, 436]': '(Trans)glycosidases', '[27, 533]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 26]': 'SignalP-noTM', '[65, 434]': 'Glycosidases', '[22, 26]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 24]': 'SignalP-noTM', '[1, 25]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[11, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[188, 531]': 'ENDO-BETA-1,6-GALACTANASE'}, 'ANU59398.1': {'[50, 256]': 'alpha-galactosidase from lactobacil brevis', '[308, 626]': '(Trans)glycosidases', '[318, 333]': 'None', '[791, 1129]': 'ENDO-BETA-1,6-GALACTANASE', '[314, 521]': 'Melibiase', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[722, 1071]': 'Glycosidases', '[321, 586]': 'glycosyl hydrolase family 36 (GH36)', '[22, 1169]': 'NON_CYTOPLASMIC_DOMAIN', '[291, 591]': 'Aldolase class I', '[1, 21]': 'SIGNAL_PEPTIDE', '[492, 508]': 'None', '[374, 396]': 'None', '[743, 1073]': '(Trans)glycosidases', '[16, 21]': 'SIGNAL_PEPTIDE_C_REGION'}, 'UBD71149.1': {'[1, 19]': 'SignalP-noTM', '[18, 485]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[4, 12]': 'SIGNAL_PEPTIDE_H_REGION', '[39, 360]': '(Trans)glycosidases', '[1, 17]': 'SIGNAL_PEPTIDE', '[16, 351]': 'Glycosidases', '[13, 17]': 'SIGNAL_PEPTIDE_C_REGION'}, 'QUT88730.1': {'[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 20]': 'SignalP-noTM', '[21, 493]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 22]': 'SignalP-TM', '[57, 390]': 'Glycosidases', '[1, 18]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[6, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[67, 349]': '(Trans)glycosidases'}, 'UWN88717.1': {'[1, 19]': 'SignalP-TM', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[16, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[79, 362]': '(Trans)glycosidases', '[40, 302]': 'Glycosidases', '[1, 21]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[20, 471]': 'NON_CYTOPLASMIC_DOMAIN'}, 'UVR10658.1': {'[161, 461]': 'Aldolase class I', '[178, 496]': '(Trans)glycosidases', '[930, 1037]': 'Golgi alpha-mannosidase II', '[184, 391]': 'Melibiase', '[244, 266]': 'None', '[661, 999]': 'ENDO-BETA-1,6-GALACTANASE', '[362, 378]': 'None', '[582, 907]': 'Glycosidases', '[2, 126]': 'alpha-galactosidase from lactobacil brevis', '[613, 943]': '(Trans)glycosidases', '[188, 203]': 'None', '[191, 456]': 'glycosyl hydrolase family 36 (GH36)'}, 'UVO70767.1': {'[19, 289]': 'Glycosidases', '[36, 291]': '(Trans)glycosidases', '[43, 386]': 'ENDO-BETA-1,6-GALACTANASE'}, 'UVO70768.1': {'[1, 24]': 'SignalP-noTM', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 22]': 'SignalP-TM', '[25, 144]': 'NON_CYTOPLASMIC_DOMAIN', '[9, 19]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[20, 24]': 'SIGNAL_PEPTIDE_C_REGION'}, 'QGT72561.1': {'[5, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 21]': 'SIGNAL_PEPTIDE', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[41, 375]': '(Trans)glycosidases', '[37, 346]': 'Glycosidases', '[22, 487]': 'NON_CYTOPLASMIC_DOMAIN', '[17, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 16]': 'Prokaryotic membrane lipoprotein lipid attachment site profile'}, 'UWO00929.1': {'[42, 278]': 'Cellulase (glycosyl hydrolase family 5)', '[1, 2]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 22]': 'SignalP-TM', '[36, 352]': 'Glycosidases', '[1, 23]': 'SignalP-noTM', '[15, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[43, 379]': '(Trans)glycosidases', '[23, 490]': 'NON_CYTOPLASMIC_DOMAIN', '[3, 14]': 'SIGNAL_PEPTIDE_H_REGION'}, 'UWO00930.1': {'[46, 372]': 'Glycosidases', '[1, 18]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[20, 505]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 19]': 'SignalP-noTM', '[16, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION', '[74, 364]': '(Trans)glycosidases'}, 'UVR93289.1': {'[19, 23]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'SIGNAL_PEPTIDE', '[58, 366]': '(Trans)glycosidases', '[24, 377]': 'Glycosidases', '[1, 21]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[24, 497]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'QZU84679.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[20, 509]': 'NON_CYTOPLASMIC_DOMAIN', '[16, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[21, 374]': 'Glycosidases', '[1, 19]': 'SignalP-noTM', '[61, 301]': '(Trans)glycosidases', '[4, 15]': 'SIGNAL_PEPTIDE_H_REGION'}, 'CBK67267.1': {'[19, 23]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'SIGNAL_PEPTIDE', '[1, 20]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[24, 495]': 'NON_CYTOPLASMIC_DOMAIN', '[44, 288]': '(Trans)glycosidases', '[22, 378]': 'Glycosidases', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'QEG33916.1': {'[27, 330]': 'Glycosidases', '[44, 315]': '(Trans)glycosidases'}, 'ABP68096.1': {'[499, 627]': 'Galactose-binding domain-like', '[11, 23]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[75, 307]': 'Cellulase (glycosyl hydrolase family 5)', '[1, 28]': 'SIGNAL_PEPTIDE', '[24, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 29]': 'TMhelix', '[391, 574]': 'Blood Group Antigen-Binding Lectin', '[15, 378]': '(Trans)glycosidases', '[511, 623]': 'F5/8 type C domain', '[29, 628]': 'NON_CYTOPLASMIC_DOMAIN', '[57, 347]': 'Glycosidases', '[377, 492]': 'Golgi alpha-mannosidase II', '[493, 628]': 'Coagulation factors 5/8 type C domain (FA58C) profile', '[501, 627]': 'Galactose-binding domain-like'}, 'BDI31947.1': {'[1, 27]': 'SignalP-TM', '[23, 30]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 30]': 'SIGNAL_PEPTIDE', '[67, 342]': '(Trans)glycosidases', '[11, 22]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[97, 390]': 'Glycosidases', '[31, 507]': 'NON_CYTOPLASMIC_DOMAIN'}, 'ADV49313.1': {'[6, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[401, 512]': 'Golgi alpha-mannosidase II', '[22, 514]': 'NON_CYTOPLASMIC_DOMAIN', '[70, 382]': '(Trans)glycosidases', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 21]': 'SIGNAL_PEPTIDE', '[28, 393]': 'Glycosidases', '[17, 21]': 'SIGNAL_PEPTIDE_C_REGION'}, 'ADV49311.1': {'[6, 16]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 20]': 'SignalP-noTM', '[21, 505]': 'NON_CYTOPLASMIC_DOMAIN', '[54, 291]': '(Trans)glycosidases', '[17, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[47, 365]': 'Glycosidases'}, 'APU67655.1': {'[45, 382]': 'Glycosidases', '[7, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[19, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 22]': 'SIGNAL_PEPTIDE', '[69, 291]': 'Cellulase (glycosyl hydrolase family 5)', '[23, 516]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 20]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[1, 26]': 'SignalP-noTM', '[74, 385]': '(Trans)glycosidases', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'APU67659.1': {'[50, 364]': '(Trans)glycosidases', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[7, 29]': 'TMhelix', '[10, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 28]': 'SignalP-noTM', '[29, 494]': 'NON_CYTOPLASMIC_DOMAIN', '[22, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[22, 375]': 'Glycosidases'}, 'WLC65246.1': {'[506, 528]': 'TMhelix', '[51, 387]': '(Trans)glycosidases', '[12, 34]': 'TMhelix', '[1, 11]': 'CYTOPLASMIC_DOMAIN', '[506, 527]': 'TRANSMEMBRANE', '[33, 505]': 'NON_CYTOPLASMIC_DOMAIN', '[314, 336]': 'TMhelix', '[528, 530]': 'CYTOPLASMIC_DOMAIN', '[12, 32]': 'TRANSMEMBRANE', '[60, 386]': 'Glycosidases'}, 'QTH43817.1': {'[64, 343]': 'Glycosidases', '[995, 1145]': 'Galactose-binding domain-like', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 27]': 'SIGNAL_PEPTIDE', '[506, 605]': 'Fibronectin type III', '[683, 838]': 'Galactose-binding domain-like', '[28, 1300]': 'NON_CYTOPLASMIC_DOMAIN', '[509, 605]': 'None', '[1146, 1300]': 'Galactose-binding domain-like', '[1, 19]': 'SignalP-TM', '[509, 617]': 'Immunoglobulins', '[508, 609]': 'Fibronectin type-III domain profile', '[6, 18]': 'SIGNAL_PEPTIDE_H_REGION', '[681, 845]': 'Galactose-binding domain-like', '[85, 405]': '(Trans)glycosidases', '[1160, 1280]': 'Carbohydrate binding domain', '[19, 27]': 'SIGNAL_PEPTIDE_C_REGION', '[1160, 1295]': 'Galactose-binding domain-like', '[397, 503]': 'Golgi alpha-mannosidase II', '[681, 814]': 'Carbohydrate binding domain'}, 'QHS51394.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 19]': 'SignalP-noTM', '[474, 789]': 'Glycosidases', '[484, 782]': 'Glycosyl hydrolase family 26', '[697, 709]': 'None', '[484, 774]': '(Trans)glycosidases', '[658, 681]': 'None', '[1, 22]': 'SignalP-TM', '[554, 568]': 'None', '[4, 14]': 'SIGNAL_PEPTIDE_H_REGION', '[20, 790]': 'NON_CYTOPLASMIC_DOMAIN', '[630, 647]': 'None', '[483, 782]': 'Glycosyl hydrolases family 26 (GH26) domain profile', '[83, 372]': 'Glycosidases', '[64, 372]': '(Trans)glycosidases', '[15, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[468, 750]': 'MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED'}, 'QWG05959.1': {'[42, 374]': 'Glycosidases', '[1, 28]': 'SignalP-noTM', '[1, 30]': 'SignalP-TM', '[29, 512]': 'NON_CYTOPLASMIC_DOMAIN', '[11, 22]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[23, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[115, 378]': '(Trans)glycosidases'}, 'ANQ50808.1': {'[1, 25]': 'SignalP-TM', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[28, 364]': 'Glycosidases', '[6, 17]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 22]': 'SIGNAL_PEPTIDE', '[18, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[23, 506]': 'NON_CYTOPLASMIC_DOMAIN', '[72, 372]': '(Trans)glycosidases'}, 'QWG01382.1': {'[21, 521]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 20]': 'SignalP-noTM', '[57, 315]': '(Trans)glycosidases', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[7, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[34, 316]': 'Glycosidases', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'UII20690.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 18]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[1, 19]': 'SignalP-TM', '[4, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 20]': 'SIGNAL_PEPTIDE', '[92, 383]': '(Trans)glycosidases', '[36, 395]': 'Glycosidases', '[21, 514]': 'NON_CYTOPLASMIC_DOMAIN'}, 'UII20686.1': {'[18, 25]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[35, 363]': 'Glycosidases', '[26, 490]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 25]': 'SIGNAL_PEPTIDE', '[4, 17]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 16]': 'SignalP-noTM', '[43, 375]': '(Trans)glycosidases'}, 'WPO86937.1': {'[579, 645]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[21, 29]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 29]': 'SignalP-noTM', '[727, 880]': 'Galactose-binding domain-like', '[94, 373]': '(Trans)glycosidases', '[1, 32]': 'SignalP-TM', '[163, 375]': 'Glycosidases', '[795, 865]': 'Galactose-binding domain-like', '[727, 837]': 'HpiC1 cyclase', '[30, 882]': 'NON_CYTOPLASMIC_DOMAIN', '[8, 20]': 'SIGNAL_PEPTIDE_H_REGION', '[7, 29]': 'TMhelix'}, 'WPO86936.1': {'[1, 33]': 'SignalP-noTM', '[26, 33]': 'SIGNAL_PEPTIDE_C_REGION', '[10, 25]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[34, 1129]': 'NON_CYTOPLASMIC_DOMAIN', '[569, 632]': 'Chitobiase/beta-hexosaminidase C-terminal domain'}, 'WEV39865.1': {'[1, 20]': 'SignalP-noTM', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[20, 31]': 'SIGNAL_PEPTIDE_C_REGION', '[40, 193]': 'Galactose-binding domain-like', '[1, 31]': 'SignalP-TM', '[9, 31]': 'TMhelix', '[32, 658]': 'NON_CYTOPLASMIC_DOMAIN', '[217, 553]': '(Trans)glycosidases', '[8, 19]': 'SIGNAL_PEPTIDE_H_REGION', '[51, 171]': 'Galactose-binding domain-like', '[238, 555]': 'Glycosidases'}, 'QHO70380.1': {'[425, 527]': 'Golgi alpha-mannosidase II', '[1, 1]': 'SIGNAL_PEPTIDE_N_REGION', '[548, 687]': 'Galactose-binding domain-like', '[1, 21]': 'SIGNAL_PEPTIDE', '[2, 13]': 'SIGNAL_PEPTIDE_H_REGION', '[22, 972]': 'NON_CYTOPLASMIC_DOMAIN', '[14, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[37, 383]': 'Glycosidases', '[67, 383]': '(Trans)glycosidases', '[690, 823]': 'Galactose-binding domain-like'}, 'APF34734.1': {'[889, 993]': 'Immunoglobulins', '[576, 642]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[5, 27]': 'TMhelix', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 33]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 33]': 'SignalP-TM', '[95, 374]': '(Trans)glycosidases', '[726, 878]': 'Galactose-binding domain-like', '[34, 1072]': 'NON_CYTOPLASMIC_DOMAIN', '[158, 378]': 'Glycosidases'}, 'BAJ75160.1': {'[570, 636]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 34]': 'SIGNAL_PEPTIDE', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[718, 867]': 'Galactose-binding domain-like', '[1, 26]': 'SignalP-noTM', '[873, 1025]': 'Galactose-binding domain-like', '[11, 26]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 33]': 'SignalP-noTM', '[67, 367]': 'Glycosidases', '[35, 1027]': 'NON_CYTOPLASMIC_DOMAIN', '[71, 349]': '(Trans)glycosidases'}, 'BAJ74095.1': {'[64, 329]': 'Glycosidases', '[23, 30]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 30]': 'SIGNAL_PEPTIDE', '[7, 22]': 'SIGNAL_PEPTIDE_H_REGION', '[719, 869]': 'Galactose-binding domain-like', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION', '[569, 634]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[7, 29]': 'TMhelix', '[31, 965]': 'NON_CYTOPLASMIC_DOMAIN', '[56, 324]': '(Trans)glycosidases'}, 'AHF17862.1': {'[1, 28]': 'SignalP-noTM', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[27, 473]': 'NON_CYTOPLASMIC_DOMAIN', '[85, 366]': '(Trans)glycosidases', '[10, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[44, 317]': 'Glycosidases', '[22, 26]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 26]': 'SIGNAL_PEPTIDE'}, 'AHF89993.1': {'[25, 33]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 27]': 'SignalP-noTM', '[13, 24]': 'SIGNAL_PEPTIDE_H_REGION', '[61, 376]': 'Glycosidases', '[466, 486]': 'mobidb-lite', '[34, 508]': 'NON_CYTOPLASMIC_DOMAIN', '[75, 363]': '(Trans)glycosidases', '[1, 35]': 'SignalP-TM', '[1, 12]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 33]': 'SIGNAL_PEPTIDE', '[7, 26]': 'TMhelix'}, 'AHF91408.1': {'[531, 546]': 'mobidb-lite', '[524, 546]': 'mobidb-lite', '[51, 370]': 'Glycosidases', '[34, 358]': '(Trans)glycosidases'}, 'WFR61027.1': {'[77, 377]': 'Glycosidases', '[78, 377]': '(Trans)glycosidases', '[35, 861]': 'NON_CYTOPLASMIC_DOMAIN', '[16, 26]': 'SIGNAL_PEPTIDE_H_REGION', '[588, 648]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[1, 15]': 'SIGNAL_PEPTIDE_N_REGION', '[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 34]': 'SIGNAL_PEPTIDE', '[12, 34]': 'TMhelix', '[1, 28]': 'SignalP-noTM'}, 'ANF97338.1': {'[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 34]': 'SignalP-TM', '[76, 376]': '(Trans)glycosidases', '[1, 14]': 'SIGNAL_PEPTIDE_N_REGION', '[687, 752]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[31, 356]': 'Glycosidases', '[557, 593]': 'mobidb-lite', '[835, 987]': 'Galactose-binding domain-like', '[1, 27]': 'SignalP-noTM', '[7, 29]': 'TMhelix', '[248, 306]': 'Glycosyl hydrolase catalytic core', '[35, 1155]': 'NON_CYTOPLASMIC_DOMAIN', '[554, 593]': 'mobidb-lite', '[997, 1152]': 'Galactose-binding domain-like', '[15, 26]': 'SIGNAL_PEPTIDE_H_REGION'}, 'WPP43235.1': {'[583, 653]': 'mobidb-lite', '[59, 344]': '(Trans)glycosidases', '[189, 306]': 'Glycosyl hydrolase catalytic core', '[943, 1027]': 'Galactose-binding domain-like', '[22, 29]': 'SIGNAL_PEPTIDE_C_REGION', '[1042, 1198]': 'Galactose-binding domain-like', '[731, 797]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[11, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 10]': 'SIGNAL_PEPTIDE_N_REGION', '[926, 1028]': 'Galactose-binding domain-like', '[1, 30]': 'SignalP-noTM', '[49, 348]': 'Glycosidases', '[520, 563]': 'mobidb-lite', '[583, 613]': 'mobidb-lite', '[1, 29]': 'SignalP-noTM', '[1031, 1062]': 'mobidb-lite', '[1, 38]': 'SignalP-TM', '[12, 31]': 'TMhelix', '[30, 1199]': 'NON_CYTOPLASMIC_DOMAIN', '[627, 653]': 'mobidb-lite'}, 'ANY71428.1': {'[26, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[14, 25]': 'SIGNAL_PEPTIDE_H_REGION', '[726, 874]': 'Galactose-binding domain-like', '[1, 32]': 'SignalP-TM', '[882, 1032]': 'Galactose-binding domain-like', '[1, 13]': 'SIGNAL_PEPTIDE_N_REGION', '[792, 873]': 'Galactose-binding domain-like', '[33, 1033]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 31]': 'SignalP-noTM', '[64, 372]': '(Trans)glycosidases', '[73, 372]': 'Glycosidases', '[189, 307]': 'Glycosyl hydrolase catalytic core', '[578, 643]': 'Chitobiase/beta-hexosaminidase C-terminal domain'}, 'WCT54208.1': {'[638, 704]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[1016, 1085]': 'Galactose-binding domain-like', '[8, 23]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[24, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[33, 1101]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 32]': 'SignalP-noTM', '[784, 935]': 'Galactose-binding domain-like', '[945, 1100]': 'Galactose-binding domain-like', '[60, 336]': '(Trans)glycosidases', '[70, 343]': 'Glycosidases', '[7, 26]': 'TMhelix'}, 'AYB42811.1': {'[63, 381]': 'Glycosidases', '[575, 648]': 'Fibronectin type III', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[22, 29]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 29]': 'SignalP-noTM', '[561, 654]': 'Fibronectin type-III domain profile', '[30, 845]': 'NON_CYTOPLASMIC_DOMAIN', '[185, 321]': 'Glycosyl hydrolase catalytic core', '[566, 658]': 'Immunoglobulins', '[8, 21]': 'SIGNAL_PEPTIDE_H_REGION', '[7, 29]': 'TMhelix', '[52, 363]': '(Trans)glycosidases'}, 'QGG55106.1': {'[644, 755]': 'F5/8 type C domain', '[423, 484]': 'mobidb-lite', '[587, 608]': 'mobidb-lite', '[91, 408]': 'Glycosidases', '[626, 773]': 'Galactose-binding domain-like', '[611, 774]': 'Coagulation factors 5/8 type C domain (FA58C) profile', '[642, 774]': 'Galactose-binding domain-like', '[110, 413]': '(Trans)glycosidases', '[781, 834]': 'mobidb-lite'}, 'WJH29034.1': {'[27, 34]': 'SIGNAL_PEPTIDE_C_REGION', '[84, 380]': '(Trans)glycosidases', '[1, 34]': 'SIGNAL_PEPTIDE', '[1, 14]': 'SIGNAL_PEPTIDE_N_REGION', '[959, 1038]': 'Galactose-binding domain-like', '[35, 1203]': 'NON_CYTOPLASMIC_DOMAIN', '[911, 1040]': 'CBM6 (carbohydrate binding type-6) domain profile', '[79, 380]': 'Glycosidases', '[736, 883]': 'Galactose-binding domain-like', '[12, 34]': 'TMhelix', '[1072, 1200]': 'Galactose-binding domain-like', '[593, 651]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[1, 25]': 'SignalP-noTM', '[15, 26]': 'SIGNAL_PEPTIDE_H_REGION', '[942, 1039]': 'Galactose-binding domain-like'}, 'QNK55806.1': {'[504, 603]': 'Fibronectin type III', '[25, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[689, 837]': 'Galactose-binding domain-like', '[509, 618]': 'Immunoglobulins', '[420, 500]': 'Glycosyl hydrolase domain', '[683, 814]': 'Carbohydrate binding domain', '[10, 24]': 'SIGNAL_PEPTIDE_H_REGION', '[71, 342]': 'Glycosidases', '[1147, 1301]': 'Galactose-binding domain-like', '[396, 503]': 'Golgi alpha-mannosidase II', '[508, 609]': 'Fibronectin type-III domain profile', '[33, 1301]': 'NON_CYTOPLASMIC_DOMAIN', '[996, 1118]': 'Carbohydrate binding domain', '[958, 1146]': 'Galactose-binding domain-like', '[1, 32]': 'SIGNAL_PEPTIDE', '[989, 1010]': 'mobidb-lite', '[1, 27]': 'SignalP-noTM', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[1159, 1296]': 'Galactose-binding domain-like', '[7, 24]': 'TMhelix', '[1158, 1281]': 'Carbohydrate binding domain', '[112, 405]': '(Trans)glycosidases', '[996, 1010]': 'mobidb-lite', '[681, 845]': 'Galactose-binding domain-like', '[1, 25]': 'SignalP-noTM'}, 'QNK57010.1': {'[31, 42]': 'SIGNAL_PEPTIDE_C_REGION', '[43, 1196]': 'NON_CYTOPLASMIC_DOMAIN', '[1044, 1196]': 'Galactose-binding domain-like', '[168, 380]': 'Glycosidases', '[886, 1037]': 'Galactose-binding domain-like', '[1113, 1191]': 'Galactose-binding domain-like', '[1, 18]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 42]': 'SIGNAL_PEPTIDE', '[582, 644]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[763, 879]': 'Galactose-binding domain-like', '[13, 35]': 'TMhelix', '[796, 861]': 'Galactose-binding domain-like', '[192, 306]': 'Glycosyl hydrolase catalytic core', '[100, 380]': '(Trans)glycosidases', '[19, 30]': 'SIGNAL_PEPTIDE_H_REGION'}, 'QNK57015.1': {'[1068, 1191]': 'Cohesin domain', '[37, 348]': 'Glycosidases', '[1, 30]': 'SignalP-TM', '[24, 32]': 'SIGNAL_PEPTIDE_C_REGION', '[753, 867]': 'Galactose-binding domain-like', '[1, 9]': 'SIGNAL_PEPTIDE_N_REGION', '[571, 635]': 'Chitobiase/beta-hexosaminidase C-terminal domain', '[1024, 1060]': 'mobidb-lite', '[887, 1045]': 'Galactose-binding domain-like', '[1290, 1358]': 'FIVAR domain', '[1368, 1426]': 'Dockerin domain', '[90, 347]': '(Trans)glycosidases', '[242, 298]': 'Glycosyl hydrolase catalytic core', '[1, 28]': 'SignalP-noTM', '[1, 32]': 'SIGNAL_PEPTIDE', '[1289, 1366]': 'AF1782-like', '[1209, 1275]': 'FIVAR domain', '[1208, 1284]': 'AF1782-like', '[1054, 1207]': 'None', '[1059, 1187]': 'Carbohydrate-binding domain', '[10, 23]': 'SIGNAL_PEPTIDE_H_REGION', '[1068, 1209]': 'Type II cohesin domain, interaction partner of dockerin', '[33, 1428]': 'NON_CYTOPLASMIC_DOMAIN'}, 'WMJ22082.1': {'[21, 319]': '(Trans)glycosidases', '[346, 435]': 'Golgi alpha-mannosidase II'}, 'UVQ47681.1': {'[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 27]': 'TMhelix', '[14, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[835, 1153]': 'ENDO-BETA-1,6-GALACTANASE', '[374, 396]': 'None', '[737, 1062]': '(Trans)glycosidases', '[480, 496]': 'None', '[295, 495]': 'glycosyl hydrolase family 36 (GH36)', '[1050, 1155]': 'Golgi alpha-mannosidase II', '[1, 21]': 'SIGNAL_PEPTIDE', '[55, 256]': 'alpha-galactosidase from lactobacil brevis', '[291, 578]': 'Aldolase class I', '[5, 13]': 'SIGNAL_PEPTIDE_H_REGION', '[318, 333]': 'None', '[302, 609]': '(Trans)glycosidases', '[22, 1158]': 'NON_CYTOPLASMIC_DOMAIN', '[193, 208]': 'None', '[317, 508]': 'Melibiase', '[709, 1030]': 'Glycosidases'}, 'BDD02170.1': {'[1, 2]': 'SIGNAL_PEPTIDE_N_REGION', '[20, 502]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 19]': 'SignalP-noTM', '[131, 279]': 'Glycosidases', '[15, 19]': 'SIGNAL_PEPTIDE_C_REGION', '[3, 14]': 'SIGNAL_PEPTIDE_H_REGION', '[37, 279]': '(Trans)glycosidases'}, 'BDD02164.1': {'[24, 397]': 'Glycosidases', '[1, 20]': 'SignalP-noTM', '[21, 518]': 'NON_CYTOPLASMIC_DOMAIN', '[420, 517]': 'Golgi alpha-mannosidase II', '[1, 5]': 'SIGNAL_PEPTIDE_N_REGION', '[64, 313]': '(Trans)glycosidases', '[1, 18]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[6, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 23]': 'SignalP-TM', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[181, 313]': 'Cellulase (glycosyl hydrolase family 5)'}, 'AGB28643.1': {'[1, 22]': 'SignalP-TM', '[7, 29]': 'TMhelix', '[366, 698]': 'ENDO-BETA-1,6-GALACTANASE', '[295, 609]': '(Trans)glycosidases', '[23, 704]': 'NON_CYTOPLASMIC_DOMAIN', '[7, 17]': 'SIGNAL_PEPTIDE_H_REGION', '[260, 573]': 'Glycosidases', '[18, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 6]': 'SIGNAL_PEPTIDE_N_REGION'}, 'AGB28629.1': {'[302, 607]': '(Trans)glycosidases', '[18, 24]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[1, 24]': 'SignalP-TM', '[761, 1067]': '(Trans)glycosidases', '[295, 585]': 'Aldolase class I', '[25, 1164]': 'NON_CYTOPLASMIC_DOMAIN', '[738, 1064]': 'Glycosidases', '[320, 514]': 'Melibiase', '[43, 258]': 'alpha-galactosidase from lactobacil brevis', '[9, 17]': 'SIGNAL_PEPTIDE_H_REGION'}, 'QMW75430.1': {'[331, 484]': 'Galactose-binding domain-like', '[1, 7]': 'SIGNAL_PEPTIDE_N_REGION', '[988, 1005]': 'TMhelix', '[1006, 1009]': 'CYTOPLASMIC_DOMAIN', '[8, 19]': 'SIGNAL_PEPTIDE_H_REGION', '[1, 28]': 'SIGNAL_PEPTIDE', '[32, 157]': 'Carbohydrate binding domain', '[9, 28]': 'TMhelix', '[183, 330]': 'Galactose-binding domain-like', '[579, 808]': '(Trans)glycosidases', '[1, 30]': 'SignalP-TM', '[29, 987]': 'NON_CYTOPLASMIC_DOMAIN', '[333, 466]': 'Carbohydrate binding domain', '[20, 28]': 'SIGNAL_PEPTIDE_C_REGION', '[955, 975]': 'Coil', '[25, 182]': 'Galactose-binding domain-like', '[329, 487]': 'Galactose-binding domain-like', '[190, 328]': 'Galactose-binding domain-like', '[31, 181]': 'Galactose-binding domain-like'}, 'QQV06122.1': {'[1061, 1137]': 'Bacterial Ig-like domain 2', '[1605, 1646]': 'Coil', '[1511, 1531]': 'Coil', '[1672, 1692]': 'Coil', '[1, 39]': 'SIGNAL_PEPTIDE', '[829, 910]': 'Bacterial Ig-like domain 2', '[1141, 1275]': 'Galactose-binding domain-like', '[73, 362]': '(Trans)glycosidases', '[40, 1738]': 'NON_CYTOPLASMIC_DOMAIN', '[1740, 1759]': 'TMhelix', '[1150, 1270]': 'F5/8 type C domain', '[1282, 1358]': 'Bacterial Ig-like domain 2', '[1648, 1735]': 'AF1782-like', '[829, 914]': 'None', '[19, 30]': 'SIGNAL_PEPTIDE_H_REGION', '[1710, 1734]': 'mobidb-lite', '[31, 39]': 'SIGNAL_PEPTIDE_C_REGION', '[1282, 1359]': 'Invasin/intimin cell-adhesion fragments', '[832, 904]': 'Bacterial Ig-like domain (group 2)', '[1058, 1140]': 'None', '[1061, 1125]': 'Bacterial Ig-like domain (group 2)', '[1513, 1586]': 'AF1782-like', '[1759, 1766]': 'CYTOPLASMIC_DOMAIN', '[1, 18]': 'SIGNAL_PEPTIDE_N_REGION', '[1739, 1758]': 'TRANSMEMBRANE', '[20, 37]': 'TMhelix', '[1541, 1561]': 'Coil', '[1282, 1361]': 'None', '[1059, 1139]': 'Invasin/intimin cell-adhesion fragments', '[1132, 1277]': 'Coagulation factors 5/8 type C domain (FA58C) profile', '[1441, 1461]': 'Coil', '[587, 670]': 'Bacterial Ig-like domain 2', '[1710, 1731]': 'mobidb-lite', '[1148, 1276]': 'Galactose-binding domain-like'}, 'ADB80105.1': {'[1, 3]': 'SIGNAL_PEPTIDE_N_REGION', '[38, 355]': 'Glycosidases', '[1, 20]': 'SignalP-noTM', '[4, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[16, 20]': 'SIGNAL_PEPTIDE_C_REGION', '[63, 359]': '(Trans)glycosidases', '[21, 477]': 'NON_CYTOPLASMIC_DOMAIN', '[1, 21]': 'Prokaryotic membrane lipoprotein lipid attachment site profile'}, 'CAZ94303.1': {'[1, 23]': 'SignalP-noTM', '[23, 517]': 'NON_CYTOPLASMIC_DOMAIN', '[36, 384]': 'Glycosidases', '[1, 21]': 'SignalP-noTM', '[1, 8]': 'SIGNAL_PEPTIDE_N_REGION', '[18, 22]': 'SIGNAL_PEPTIDE_C_REGION', '[1, 22]': 'SIGNAL_PEPTIDE', '[69, 300]': '(Trans)glycosidases', '[1, 17]': 'Prokaryotic membrane lipoprotein lipid attachment site profile', '[9, 17]': 'SIGNAL_PEPTIDE_H_REGION'}, 'CBK67650.1': {'[711, 1037]': 'Glycosidases', '[318, 333]': 'None', '[1, 4]': 'SIGNAL_PEPTIDE_N_REGION', '[5, 15]': 'SIGNAL_PEPTIDE_H_REGION', '[321, 586]': 'glycosyl hydrolase family 36 (GH36)', '[1, 21]': 'SignalP-noTM', '[791, 1129]': 'ENDO-BETA-1,6-GALACTANASE', '[54, 256]': 'alpha-galactosidase from lactobacil brevis', '[741, 1073]': '(Trans)glycosidases', '[308, 626]': '(Trans)glycosidases', '[22, 1169]': 'NON_CYTOPLASMIC_DOMAIN', '[492, 508]': 'None', '[314, 521]': 'Melibiase', '[374, 396]': 'None', '[16, 21]': 'SIGNAL_PEPTIDE_C_REGION', '[291, 591]': 'Aldolase class I', '[1060, 1167]': 'Golgi alpha-mannosidase II'}}\n"
     ]
    }
   ],
   "source": [
    "def position_domains_dict(positiondict, domaindict):\n",
    "    \"\"\"Creates a dictionary that contains for every entry, for every found domainpositions, the corresponding domainname\"\"\"\n",
    "    \n",
    "    alldomainsdict = {}\n",
    "    for key, value in positiondict.items():\n",
    "        tempdict = {}\n",
    "        for positions in value:\n",
    "            placeinlist = value.index(positions)\n",
    "            domainsinseq = domaindict[key]\n",
    "            domainlist = domainsinseq[placeinlist]\n",
    "            tempdict[str(positions)] = domainlist[1] \n",
    "        alldomainsdict[key] = tempdict\n",
    "                   \n",
    "    print(alldomainsdict)\n",
    "    \n",
    "    return alldomainsdict\n",
    "\n",
    "all_domains_in_seq = position_domains_dict(finddomains[1], finddomainnames[0])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 70,
   "id": "8cab26c5",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ATO84721.1': [[[358, 495], '(Trans)glycosidases']], 'BBL06275.1': [[[4, 240], '(Trans)glycosidases']], 'BBL01040.1': [[[30, 348], '(Trans)glycosidases']], 'UWN65549.1': [[[125, 430], '(Trans)glycosidases']], 'CBK63196.1': [[[47, 381], '(Trans)glycosidases']], 'UZO80939.1': [[[75, 373], '(Trans)glycosidases']], 'UZO80937.1': [[[70, 314], '(Trans)glycosidases']], 'AGY53053.1': [[[57, 284], '(Trans)glycosidases']], 'ANU59401.1': [[[181, 436], '(Trans)glycosidases']], 'ANU59398.1': [[[50, 256], 'alpha-galactosidase from lactobacil brevis'], [[321, 586], 'glycosyl hydrolase family 36 (GH36)'], [[743, 1073], '(Trans)glycosidases']], 'UBD71149.1': [[[39, 360], '(Trans)glycosidases']], 'QUT88730.1': [[[67, 349], '(Trans)glycosidases']], 'UWN88717.1': [[[79, 362], '(Trans)glycosidases']], 'UVR10658.1': [[[2, 126], 'alpha-galactosidase from lactobacil brevis'], [[191, 456], 'glycosyl hydrolase family 36 (GH36)'], [[613, 943], '(Trans)glycosidases'], [[930, 1037], 'Golgi alpha-mannosidase II']], 'UVO70767.1': [[[36, 291], '(Trans)glycosidases']], 'UVO70768.1': [], 'QGT72561.1': [[[41, 375], '(Trans)glycosidases']], 'UWO00929.1': [[[43, 379], '(Trans)glycosidases']], 'UWO00930.1': [[[74, 364], '(Trans)glycosidases']], 'UVR93289.1': [[[58, 366], '(Trans)glycosidases']], 'QZU84679.1': [[[61, 301], '(Trans)glycosidases']], 'CBK67267.1': [[[44, 288], '(Trans)glycosidases']], 'QEG33916.1': [[[44, 315], '(Trans)glycosidases']], 'ABP68096.1': [[[15, 378], '(Trans)glycosidases'], [[501, 627], 'Galactose-binding domain-like']], 'BDI31947.1': [[[67, 342], '(Trans)glycosidases']], 'ADV49313.1': [[[70, 382], '(Trans)glycosidases'], [[401, 512], 'Golgi alpha-mannosidase II']], 'ADV49311.1': [[[54, 291], '(Trans)glycosidases']], 'APU67655.1': [[[74, 385], '(Trans)glycosidases']], 'APU67659.1': [[[50, 364], '(Trans)glycosidases']], 'WLC65246.1': [[[51, 387], '(Trans)glycosidases']], 'QTH43817.1': [[[85, 405], '(Trans)glycosidases'], [[397, 503], 'Golgi alpha-mannosidase II'], [[506, 605], 'Fibronectin type III'], [[683, 838], 'Galactose-binding domain-like'], [[995, 1145], 'Galactose-binding domain-like'], [[1160, 1295], 'Galactose-binding domain-like']], 'QHS51394.1': [[[64, 372], '(Trans)glycosidases'], [[484, 774], '(Trans)glycosidases']], 'QWG05959.1': [[[115, 378], '(Trans)glycosidases']], 'ANQ50808.1': [[[72, 372], '(Trans)glycosidases']], 'QWG01382.1': [[[57, 315], '(Trans)glycosidases']], 'UII20690.1': [[[92, 383], '(Trans)glycosidases']], 'UII20686.1': [[[43, 375], '(Trans)glycosidases']], 'WPO86937.1': [[[94, 373], '(Trans)glycosidases'], [[579, 645], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[795, 865], 'Galactose-binding domain-like']], 'WPO86936.1': [[[569, 632], 'Chitobiase/beta-hexosaminidase C-terminal domain']], 'WEV39865.1': [[[51, 171], 'Galactose-binding domain-like'], [[217, 553], '(Trans)glycosidases']], 'QHO70380.1': [[[67, 383], '(Trans)glycosidases'], [[425, 527], 'Golgi alpha-mannosidase II'], [[548, 687], 'Galactose-binding domain-like'], [[690, 823], 'Galactose-binding domain-like']], 'APF34734.1': [[[95, 374], '(Trans)glycosidases'], [[576, 642], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[726, 878], 'Galactose-binding domain-like'], [[889, 993], 'Immunoglobulins']], 'BAJ75160.1': [[[71, 349], '(Trans)glycosidases'], [[570, 636], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[718, 867], 'Galactose-binding domain-like'], [[873, 1025], 'Galactose-binding domain-like']], 'BAJ74095.1': [[[56, 324], '(Trans)glycosidases'], [[569, 634], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[719, 869], 'Galactose-binding domain-like']], 'AHF17862.1': [[[85, 366], '(Trans)glycosidases']], 'AHF89993.1': [[[75, 363], '(Trans)glycosidases']], 'AHF91408.1': [[[34, 358], '(Trans)glycosidases']], 'WFR61027.1': [[[78, 377], '(Trans)glycosidases'], [[588, 648], 'Chitobiase/beta-hexosaminidase C-terminal domain']], 'ANF97338.1': [[[76, 376], '(Trans)glycosidases'], [[687, 752], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[835, 987], 'Galactose-binding domain-like'], [[997, 1152], 'Galactose-binding domain-like']], 'WPP43235.1': [[[59, 344], '(Trans)glycosidases'], [[731, 797], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[943, 1027], 'Galactose-binding domain-like'], [[1042, 1198], 'Galactose-binding domain-like']], 'ANY71428.1': [[[64, 372], '(Trans)glycosidases'], [[578, 643], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[792, 873], 'Galactose-binding domain-like'], [[882, 1032], 'Galactose-binding domain-like']], 'WCT54208.1': [[[60, 336], '(Trans)glycosidases'], [[638, 704], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[784, 935], 'Galactose-binding domain-like'], [[1016, 1085], 'Galactose-binding domain-like']], 'AYB42811.1': [[[52, 363], '(Trans)glycosidases'], [[575, 648], 'Fibronectin type III']], 'QGG55106.1': [[[110, 413], '(Trans)glycosidases'], [[642, 774], 'Galactose-binding domain-like']], 'WJH29034.1': [[[84, 380], '(Trans)glycosidases'], [[593, 651], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[736, 883], 'Galactose-binding domain-like'], [[911, 1040], 'CBM6 (carbohydrate binding type-6) domain profile'], [[1072, 1200], 'Galactose-binding domain-like']], 'QNK55806.1': [[[112, 405], '(Trans)glycosidases'], [[420, 500], 'Glycosyl hydrolase domain'], [[504, 603], 'Fibronectin type III'], [[683, 814], 'Carbohydrate binding domain'], [[996, 1118], 'Carbohydrate binding domain'], [[1158, 1281], 'Carbohydrate binding domain']], 'QNK57010.1': [[[100, 380], '(Trans)glycosidases'], [[582, 644], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[796, 861], 'Galactose-binding domain-like'], [[886, 1037], 'Galactose-binding domain-like'], [[1113, 1191], 'Galactose-binding domain-like']], 'QNK57015.1': [[[90, 347], '(Trans)glycosidases'], [[571, 635], 'Chitobiase/beta-hexosaminidase C-terminal domain'], [[753, 867], 'Galactose-binding domain-like'], [[887, 1045], 'Galactose-binding domain-like'], [[1068, 1209], 'Type II cohesin domain, interaction partner of dockerin'], [[1209, 1275], 'FIVAR domain'], [[1290, 1358], 'FIVAR domain'], [[1368, 1426], 'Dockerin domain']], 'WMJ22082.1': [[[21, 319], '(Trans)glycosidases'], [[346, 435], 'Golgi alpha-mannosidase II']], 'UVQ47681.1': [[[55, 256], 'alpha-galactosidase from lactobacil brevis'], [[295, 495], 'glycosyl hydrolase family 36 (GH36)'], [[737, 1062], '(Trans)glycosidases']], 'BDD02170.1': [[[37, 279], '(Trans)glycosidases']], 'BDD02164.1': [[[64, 313], '(Trans)glycosidases'], [[420, 517], 'Golgi alpha-mannosidase II']], 'AGB28643.1': [[[295, 609], '(Trans)glycosidases']], 'AGB28629.1': [[[43, 258], 'alpha-galactosidase from lactobacil brevis'], [[302, 607], '(Trans)glycosidases'], [[761, 1067], '(Trans)glycosidases']], 'QMW75430.1': [[[31, 181], 'Galactose-binding domain-like'], [[190, 328], 'Galactose-binding domain-like'], [[331, 484], 'Galactose-binding domain-like'], [[579, 808], '(Trans)glycosidases']], 'QQV06122.1': [[[73, 362], '(Trans)glycosidases'], [[587, 670], 'Bacterial Ig-like domain 2'], [[829, 910], 'Bacterial Ig-like domain 2'], [[1061, 1137], 'Bacterial Ig-like domain 2'], [[1148, 1276], 'Galactose-binding domain-like'], [[1282, 1358], 'Bacterial Ig-like domain 2'], [[1513, 1586], 'AF1782-like'], [[1648, 1735], 'AF1782-like']], 'ADB80105.1': [[[63, 359], '(Trans)glycosidases']], 'CAZ94303.1': [[[69, 300], '(Trans)glycosidases']], 'CBK67650.1': [[[54, 256], 'alpha-galactosidase from lactobacil brevis'], [[321, 586], 'glycosyl hydrolase family 36 (GH36)'], [[741, 1073], '(Trans)glycosidases'], [[1060, 1167], 'Golgi alpha-mannosidase II']]}\n",
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "def overlap(a, b):\n",
    "    \"\"\"This function has two domains as an input. They are sorted by their position in the protein sequence.\n",
    "    If they have overlapping positions, the overlap percentage is calculated. \n",
    "    If it is above a certain cut-off, the two domains are considered to be the same\"\"\"\n",
    "    \n",
    "    #sort again\n",
    "    sortinglist = [a, b]\n",
    "    sortinglist.sort()\n",
    "    a = sortinglist[0]\n",
    "    b = sortinglist[1]\n",
    "    \n",
    "    x1, y1 = a[0], a[1]\n",
    "    length1 = y1 - x1\n",
    "    \n",
    "    x2, y2 = b[0], b[1]\n",
    "    length2 = y2 - x2\n",
    "    \n",
    "    if y1 in range(x2, y2+1):\n",
    "        #in the uncommon scenario that a 'domain' only consists of 1 AA\n",
    "        if x1 == y1 or x2 == y2:\n",
    "            identity = 1\n",
    "        else:\n",
    "            over = y1 - x2\n",
    "            identity = min(over/length1,over/length2)\n",
    "        \n",
    "    elif x2 in range (x1, y1+1) and y2 in range(x1, y1+1):\n",
    "        #this means that the second domain falls in the range of the first domain\n",
    "        #we'll consider these domains to be the same\n",
    "        identity = 100\n",
    "    \n",
    "    else:\n",
    "        identity = 0\n",
    "    \n",
    "    #if the identity between the domains is higher than this cut-off we assume they are the same domain\n",
    "    #there is no fixed value for this cut-off. The user could play around with this value and make it more/less strict\n",
    "    return(identity > overlap_percentagecutoff/100)\n",
    "        \n",
    "def extract_overlap(domainlist):\n",
    "    \"\"\"This function gets a list of all the domains and their positions found in a protein sequence as an input.\n",
    "    It uses the overlap function to iterate over this list and it groups all domains we consider to be the same in a list.\n",
    "    The output is a list of lists with every sublist representing an unique domain\"\"\"\n",
    "    \n",
    "    #create a list containing the final domain composition\n",
    "    outputlist = []\n",
    "    \n",
    "    #create a temporary list that is used while iterating over all the domains, using the overlap function\n",
    "    templist = []\n",
    "    \n",
    "    #sort the inputlist according to their position in the protein sequence. N-terminus -> C-terminus\n",
    "    domainlist = sorted(domainlist, key=lambda x: (x[0], x[1]))\n",
    "    \n",
    "    i = 0\n",
    "    while i in range(len(domainlist)):\n",
    "        \n",
    "        if i == len(domainlist) - 1:\n",
    "            if len(templist) != 0:\n",
    "                #remove doubles from templist\n",
    "                templist.sort()\n",
    "                templist = list(templist for templist,_ in itertools.groupby(templist))\n",
    "                outputlist.append(templist)\n",
    "            else:\n",
    "                outputlist.append(domainlist[i])\n",
    "            break\n",
    "            \n",
    "        #if the domains are found to be the same (overlap > cut-off)\n",
    "        elif overlap(domainlist[i], domainlist[i+1]) == True:\n",
    "            templist += domainlist[i], domainlist[i+1]\n",
    "            i += 1\n",
    "            \n",
    "        else:\n",
    "            \n",
    "            if len(templist) != 0:\n",
    "                #remove doubles from templist\n",
    "                templist.sort()\n",
    "                templist = list(templist for templist,_ in itertools.groupby(templist))\n",
    "                outputlist.append(templist)\n",
    "                templist = [] \n",
    "                \n",
    "            else:\n",
    "                outputlist.append(domainlist[i])\n",
    "            i += 1\n",
    "            \n",
    "    return outputlist\n",
    "\n",
    "def clean_domains(finddomains, alldomainsdict, databaseoutput):\n",
    "    \"\"\"This function uses the extract_overlap output as input, which is for every protein a list of sublists.\n",
    "    Every sublist represents a protein domain at a unique position in the sequence. The clean_domains function decides \n",
    "    which of the coördinates in the sublist (and corresponding domain name) is used for the final representation of the \n",
    "    proteins' domain architecture. The selection is based on database-preference.\"\"\"\n",
    "\n",
    "    \n",
    "    databasepreference = ['SMART', 'CDD','SUPERFAMILY', 'PFAM','NCBIFAM', 'PANTHER',' GENE3D', 'PIRSF', 'HAMAP', 'PRINTS', 'SFLD', 'PROFILE', 'PROSITE' ]\n",
    "    finaldomainoutput = {}\n",
    "    \n",
    "    #following comments show a practical example of this function\n",
    "    #finddomains[1]\n",
    "    #{'AFY45032.1': [[369, 787], [41, 372], [421, 796], [31, 801], [1, 802]], ...\n",
    "    \n",
    "    for key, val in finddomains[1].items():\n",
    "\n",
    "        #val\n",
    "        #[[369, 787], [41, 372], [421, 796], [31, 801], [1, 802]]\n",
    "        \n",
    "        numberofdomains = len(val)\n",
    "        temporarylength = 0\n",
    "       \n",
    "        #do the extract_overlap iteration several times, to otain one clean result without severely overlapping domains\n",
    "        #while length of the previous input != len(val) \n",
    "        while temporarylength != len(val):\n",
    "            \n",
    "            #length of the previous input\n",
    "            temporarylength = len(val)\n",
    "            \n",
    "            extract_overlap_dict = {}\n",
    "            \n",
    "            #use the overlap and extract_overlap functions to create a dictionary with the identifiers as keys \n",
    "            #and the unique positions containing a domains as values\n",
    "            domaincomposition = extract_overlap(val)\n",
    "            extract_overlap_dict[key] = domaincomposition\n",
    "            #{'AFY45032.1': [[[1, 802], [31, 801], [41, 372]], [[369, 787], [421, 796]]]}\n",
    "\n",
    "            for key, value in extract_overlap_dict.items():\n",
    "                #key\n",
    "                #'AFY45032.1'\n",
    "                #value\n",
    "                #[[[1, 802], [31, 801], [41, 372]], [[369, 787], [421, 796]]]\n",
    "                \n",
    "                numberofdomains = len(value)\n",
    "\n",
    "                temporaryoutput = []\n",
    "                cleanedpositiondict = {}\n",
    "                cleanedpositionlist = []\n",
    "\n",
    "                for domain in value:\n",
    "                    #domain\n",
    "                    #[[1, 802], [31, 801], [41, 372]] and [[369, 787], [421, 796]]\n",
    "                    \n",
    "                    #there can only be one position pair for this domain\n",
    "                    if all(isinstance(x, int) for x in domain):\n",
    "                        dname = alldomainsdict[key][str(domain)]\n",
    "                        db = databaseoutput[key][dname]\n",
    "\n",
    "                        #we'll not include signal peptides\n",
    "                        #also for some domains we could not retrieve a name. These domains are called 'None' and will not be included\n",
    "                        if dname != 'None' and dname != 'Prokaryotic membrane lipoprotein lipid attachment site profile' and db != 'PHOBIUS' and db != 'FUNFAM' and db.upper().find('SIGNAL') == -1 and db != 'TMHMM' and db != 'MOBIDB_LITE' and db != 'COILS': #and db != 'COILS'\n",
    "                            temporaryoutput.append([domain, dname])\n",
    "                            cleanedpositionlist.append(domain)\n",
    "\n",
    "\n",
    "                    else:\n",
    "                        #this means that we have multiple positions describing the same domain\n",
    "                        tempdict = {}\n",
    "                        tempposition = {}\n",
    "                        for simdomain in domain:\n",
    "                            \n",
    "                            #first filter on length. Very long domains may disrupt the output\n",
    "                            #they usually comprise several individual domains of the proteins and are faulty outputs\n",
    "                            #from the member databases \n",
    "                            \n",
    "                            domainlength = simdomain[1] - simdomain[0]\n",
    "                            #simdomain\n",
    "                            #[1, 802]\n",
    "                            dname = alldomainsdict[key][str(simdomain)]\n",
    "                            db = databaseoutput[key][dname]\n",
    "\n",
    "                            #we'll not include signal peptides\n",
    "                            if dname != 'None' and dname != 'Prokaryotic membrane lipoprotein lipid attachment site profile' and db != 'PHOBIUS' and db.upper().find('SIGNAL') == -1 and dname.upper().find('SIGNAL') == -1 and domainlength >= 10 and domainlength <=max_domainlength and db != 'TMHMM' and db != 'MOBIDB_LITE' and db != 'COILS': #db != 'COILS'\n",
    "                                tempdict[dname] = db\n",
    "                                tempposition[dname] = simdomain\n",
    "                        \n",
    "                        #if the tempdict is not empty\n",
    "                        if bool(tempdict) == True:\n",
    "                            #iterate over the dictionary\n",
    "                            count = 0\n",
    "                            stop = 0\n",
    "                            \n",
    "                            #create a temporary dict where we will store the position of the database domain was retrieved from\n",
    "                            domaindatabasescore = {}\n",
    "                            \n",
    "                            for k, v in tempdict.items():\n",
    "    \n",
    "                                #print(f'length tempdict: {len(tempdict)}  ')\n",
    "                                #while stop == 0:\n",
    "\n",
    "                                for i in range(len(databasepreference)): \n",
    "                                    # clean the output based on the database preference. Order matters\n",
    "\n",
    "                                    if v == databasepreference[i]:\n",
    "\n",
    "                                        #create a temprary domaindatabasescore e.g., {0: 'catalytic domain', 3:'...'}\n",
    "                                        domaindatabasescore[i] = k\n",
    "                                        #\n",
    "                                count += 1\n",
    "\n",
    "                            if len(domaindatabasescore) != 0:\n",
    "\n",
    "                                sorteddomainlist = sorted(domaindatabasescore)\n",
    "                                dom = domaindatabasescore[sorteddomainlist[0]]\n",
    "                                #choose the first domain in the list, meaning it has hgihest priority in\n",
    "                                #the database preference\n",
    "                                temporaryoutput.append([tempposition[dom], dom])\n",
    "                                cleanedpositionlist.append(tempposition[dom])\n",
    "                                stop = 1\n",
    "\n",
    "                            else:\n",
    "\n",
    "\n",
    "                                #when we reached the length of the tempdict, stop the iteration. This will be the final output\n",
    "                                #dom = the domain name\n",
    "                                dom = list(tempposition.keys())[0]\n",
    "                                #create a list of lists containing the position and name of the domain\n",
    "                                temporaryoutput.append([tempposition[dom], dom])\n",
    "                                cleanedpositionlist.append(tempposition[dom])\n",
    "                                stop = 1        \n",
    "\n",
    "\n",
    "                finaldomainoutput[key] = temporaryoutput \n",
    "                #{'AFY45032.1': [[[1, 802], 'Beta-glucosidase, GBA2 type'], [[369, 787], 'Six-hairpin glycosidases']],...\n",
    "            \n",
    "            #update the val so the iteration can go on    \n",
    "            val = cleanedpositionlist\n",
    "                \n",
    "        finaldomainoutput[key] = temporaryoutput\n",
    "    print(finaldomainoutput) \n",
    "    print('Finished!')\n",
    "    return finaldomainoutput\n",
    "\n",
    "finaldomainarchitecture = clean_domains(finddomains, all_domains_in_seq, finddomainnames[1] )\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "2a708c51",
   "metadata": {},
   "source": [
    "# Data curation"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 71,
   "id": "3cfd3201",
   "metadata": {
    "scrolled": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{0: '(Trans)glycosidases', 1: 'alpha-galactosidase from lactobacil brevis', 2: 'glycosyl hydrolase family 36 (GH36)', 3: 'Golgi alpha-mannosidase II', 4: 'Galactose-binding domain-like', 5: 'Fibronectin type III', 6: 'Chitobiase/beta-hexosaminidase C-terminal domain', 7: 'Immunoglobulins', 8: 'CBM6 (carbohydrate binding type-6) domain profile', 9: 'Glycosyl hydrolase domain', 10: 'Carbohydrate binding domain', 11: 'Type II cohesin domain, interaction partner of dockerin', 12: 'FIVAR domain', 13: 'Dockerin domain', 14: 'Bacterial Ig-like domain 2', 15: 'AF1782-like'}\n",
      "\n",
      "Lets curate the domain names!\n",
      "This step can be useful because the domains are retrieved from several databases which often have different names for the same domain. \n",
      "In the first input option, enter the domain name you want to use for the remainder of this workflow. \n",
      "Then, enter the number of the domain(s)(0 - 16) you want to include in this umbrella domain name, separated by a ','. For example: \n",
      "\n",
      "Domain name: Catalytic domain\n",
      "Includes: 0,2,5 \n",
      "\n",
      "When finished, write 'stop'. The proces will be continued with the curated domain names.\n",
      "\n",
      "\n",
      "Domains still to curate: \n",
      "\n",
      "0: (Trans)glycosidases\n",
      "1: alpha-galactosidase from lactobacil brevis\n",
      "2: glycosyl hydrolase family 36 (GH36)\n",
      "3: Golgi alpha-mannosidase II\n",
      "4: Galactose-binding domain-like\n",
      "5: Fibronectin type III\n",
      "6: Chitobiase/beta-hexosaminidase C-terminal domain\n",
      "7: Immunoglobulins\n",
      "8: CBM6 (carbohydrate binding type-6) domain profile\n",
      "9: Glycosyl hydrolase domain\n",
      "10: Carbohydrate binding domain\n",
      "11: Type II cohesin domain, interaction partner of dockerin\n",
      "12: FIVAR domain\n",
      "13: Dockerin domain\n",
      "14: Bacterial Ig-like domain 2\n",
      "15: AF1782-like\n",
      "\n",
      "Domain name: stop\n",
      "\n",
      "Curated domain dictionary: {'(Trans)glycosidases': ['(Trans)glycosidases'], 'alpha-galactosidase from lactobacil brevis': ['alpha-galactosidase from lactobacil brevis'], 'glycosyl hydrolase family 36 (GH36)': ['glycosyl hydrolase family 36 (GH36)'], 'Golgi alpha-mannosidase II': ['Golgi alpha-mannosidase II'], 'Galactose-binding domain-like': ['Galactose-binding domain-like'], 'Fibronectin type III': ['Fibronectin type III'], 'Chitobiase/beta-hexosaminidase C-terminal domain': ['Chitobiase/beta-hexosaminidase C-terminal domain'], 'Immunoglobulins': ['Immunoglobulins'], 'CBM6 (carbohydrate binding type-6) domain profile': ['CBM6 (carbohydrate binding type-6) domain profile'], 'Glycosyl hydrolase domain': ['Glycosyl hydrolase domain'], 'Carbohydrate binding domain': ['Carbohydrate binding domain'], 'Type II cohesin domain, interaction partner of dockerin': ['Type II cohesin domain, interaction partner of dockerin'], 'FIVAR domain': ['FIVAR domain'], 'Dockerin domain': ['Dockerin domain'], 'Bacterial Ig-like domain 2': ['Bacterial Ig-like domain 2'], 'AF1782-like': ['AF1782-like']}\n"
     ]
    }
   ],
   "source": [
    "#In this step we'll curate the names of the domains\n",
    "#The user will be able to input a domain name which groups all synonymous names describing the same domain\n",
    "\n",
    "def create_domain_list(finaldomainarchitecture):\n",
    "    \"\"\"This function creates a list and dictionary, containing the several domain names that have been found\"\"\"\n",
    "    \n",
    "    #first create a list containing unique protein domain names\n",
    "    domain_list = []\n",
    "    for value in finaldomainarchitecture.values():\n",
    "        for domains in value:\n",
    "            domainname = domains[1]\n",
    "            if domainname not in domain_list:\n",
    "                domain_list.append(domainname)\n",
    "    \n",
    "    #then use the list to create a dictionary. WIth the keys being the position of every domain in the domain_list\n",
    "    found_domains_dict = {}\n",
    "    for i in range(len(domain_list)):\n",
    "        found_domains_dict[i] = domain_list[i]\n",
    "        \n",
    "    return domain_list, found_domains_dict\n",
    "\n",
    "def print_dictionary(dictionary):\n",
    "    \"\"\"This function prints out the keys and values of a dictionary\"\"\"\n",
    "                                   \n",
    "    print('\\nDomains still to curate: \\n')\n",
    "    for key, value in dictionary.items():\n",
    "        print(f'{key}: {value}')\n",
    "                                   \n",
    "    return\n",
    "\n",
    "def data_curation(finaldomainarchitecture):\n",
    "    \"\"\"This function allowd the user to curate the data\"\"\"\n",
    "    \n",
    "    unique_domains = create_domain_list(finaldomainarchitecture)\n",
    "    \n",
    "    #create a list containing unique domain names\n",
    "    domain_list = unique_domains[0]\n",
    "    #create a dictionary with the positions of the domain names in the list as keys and the names as values\n",
    "    found_domains_dict = unique_domains[1]\n",
    "    print(found_domains_dict)\n",
    "    \n",
    "    print(f\"\"\"\\nLets curate the domain names!\n",
    "This step can be useful because the domains are retrieved from several databases which often have different names for the same domain. \n",
    "In the first input option, enter the domain name you want to use for the remainder of this workflow. \n",
    "Then, enter the number of the domain(s)(0 - {len(domain_list)}) you want to include in this umbrella domain name, separated by a ','. For example: \\n\n",
    "Domain name: Catalytic domain\n",
    "Includes: 0,2,5 \\n\n",
    "When finished, write 'stop'. The proces will be continued with the curated domain names.\n",
    "\"\"\")\n",
    "    \n",
    "    #store the curated domain names\n",
    "    curated_dictionary = {}\n",
    "    \n",
    "    #go over all domain names\n",
    "    for i in range(len(found_domains_dict)):\n",
    "        \n",
    "        #print which domains we still need to curate\n",
    "        print_dictionary(found_domains_dict)\n",
    "        \n",
    "        #the user can input the name for the domain \n",
    "        domainname = input('\\nDomain name: ')\n",
    "        \n",
    "        #if the user is done, all names that haven't been curated will be included in the curated_dicionary as is\n",
    "        if domainname.upper() == 'STOP':\n",
    "            for domain in found_domains_dict.values():\n",
    "                curated_dictionary[domain] = [domain]\n",
    "            break\n",
    "            \n",
    "        #the user can input which domains are synonymous \n",
    "        synonymousnames = input('Includes: ')\n",
    "        synonymousnames = synonymousnames.strip().split(',')\n",
    "        \n",
    "        #create a list containing all the synonymous domain names\n",
    "        dictvalue = []\n",
    "        for number in synonymousnames:\n",
    "            #append tthe names to the name list\n",
    "            dictvalue.append(domain_list[int(number)])\n",
    "            \n",
    "            #remove this domain name from the input dictionary\n",
    "            found_domains_dict.pop(int(number))\n",
    "        \n",
    "        #add the inputed domain name as key and synonymous name(s) as value to the output dictionary\n",
    "        curated_dictionary[domainname] = dictvalue\n",
    "    \n",
    "    return curated_dictionary\n",
    "                                   \n",
    "curated_domains = data_curation(finaldomainarchitecture)\n",
    "print(f'\\nCurated domain dictionary: {curated_domains}')\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "cae8e24e",
   "metadata": {},
   "source": [
    "# Write results to SQL db"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 72,
   "id": "6a0fd20c",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Database created.\n",
      "Database populated.\n"
     ]
    }
   ],
   "source": [
    "import sqlite3\n",
    "\n",
    "\n",
    "def parse_prot_seq(fastafile):\n",
    "    \"\"\"Parses through the fastafile containing the protein sequences\"\"\"\n",
    "    \n",
    "    with open(fastafile, 'r') as f:\n",
    "        sequences = SeqIO.parse(f, \"fasta\")\n",
    "        modified_sequences = []\n",
    "        \n",
    "        for seq_record in sequences:\n",
    "            modified_sequences.append(seq_record)\n",
    "    \n",
    "    return modified_sequences\n",
    "\n",
    "\n",
    "def create_database():\n",
    "    \"\"\"Function to create the SQLite database and tabless\"\"\"\n",
    "    \n",
    "    # Connect to the database (or create it if it doesn't exist)\n",
    "    conn = sqlite3.connect(os.path.join(jobname, f\"{jobname}_db.db\"))\n",
    "    c = conn.cursor()\n",
    "\n",
    "    # Create ProteinSequences table\n",
    "    c.execute('''CREATE TABLE ProteinSequences (\n",
    "                 protein_sequence_id TEXT PRIMARY KEY,\n",
    "                 taxonomy TEXT,\n",
    "                 characterized TEXT,\n",
    "                 organism_name TEXT,\n",
    "                 amino_acid_sequence TEXT,\n",
    "                 domain_architecture TEXT,\n",
    "                 domain_locations TEXT,\n",
    "                 domain_databases TEXT\n",
    "                 )''')\n",
    "\n",
    "    # Create DomainAssemblies table\n",
    "    c.execute('''CREATE TABLE DomainAssemblies (\n",
    "                 protein_domain TEXT PRIMARY KEY,\n",
    "                 protein_sequence_id TEXT\n",
    "                 )''')\n",
    "\n",
    "    # Create DomainCuration table\n",
    "    c.execute('''CREATE TABLE DomainCuration (\n",
    "                 domain_name TEXT PRIMARY KEY,\n",
    "                 synonymous_domain_name TEXT\n",
    "                 )''')\n",
    "\n",
    "    # Commit changes and close connection\n",
    "    conn.commit()\n",
    "    conn.close()\n",
    "    \n",
    "    print('Database created.')\n",
    "    \n",
    "    return\n",
    "\n",
    "\n",
    "def populate_database(chardict, proteinfile, domaindictionary, databasedictionary, curated_domains):\n",
    "    \"\"\"Function to insert  data into the tables\"\"\"\n",
    "    \n",
    "    # Connect to the database\n",
    "    conn = sqlite3.connect(os.path.join(jobname, f\"{jobname}_db.db\"))\n",
    "    c = conn.cursor()\n",
    "    \n",
    "    #dictionary used to annotate the domains of life\n",
    "    taxdictionary = {'B': 'Bacteria', 'A': 'Archaea', 'E': 'Eukaryota', 'V': 'Viruses', 'U': 'Unclassified'}\n",
    "    domainarchitectures = {}\n",
    "    \n",
    "    #Fetch the records for the ProteinSequences table\n",
    "    protein_sequences_data = []\n",
    "    for seq_record in proteinfile:\n",
    "        \n",
    "        seq_id = seq_record.id.split('_')[0]\n",
    "        seq_org = ' '.join(seq_record.id.split('_')[1:-1])\n",
    "        seq_seq = str(seq_record.seq)\n",
    "        seq_tax = taxdictionary[seq_record.id[-1]]\n",
    "        seq_char = ''\n",
    "        seq_dom = ''\n",
    "        seq_loc = ''\n",
    "        dom_db = ''\n",
    "        \n",
    "        if seq_id in chardict:\n",
    "            seq_char = 'C'\n",
    "        \n",
    "        if seq_id in domaindictionary and seq_id in databasedictionary:\n",
    "\n",
    "            for domain in domaindictionary[seq_id]:\n",
    "                \n",
    "                domainname = domain[1]\n",
    "                \n",
    "                #retrieve the curated name\n",
    "                for umbrellaname, includednames in curated_domains.items():\n",
    "                    #go over all the names that were included in a list to the corresponding umbrella domain name (key)\n",
    "                    for name in includednames:\n",
    "                        if name == domainname:\n",
    "                            domainname = umbrellaname\n",
    "                        \n",
    "                            seq_dom += domainname + '--'\n",
    "                            \n",
    "                seq_loc += str(domain[0]) + '--'\n",
    "                \n",
    "                dom_db += databasedictionary[seq_id][domain[1]] + '--'\n",
    "                    \n",
    "        seq_dom = seq_dom.rstrip('--')\n",
    "        seq_loc = seq_loc.rstrip('--')\n",
    "        dom_db = dom_db.rstrip('--')\n",
    "    \n",
    "        if seq_dom not in domainarchitectures:\n",
    "            domainarchitectures[seq_dom] = [seq_id]\n",
    "            \n",
    "        else:\n",
    "            domainarchitectures[seq_dom].append(seq_id)\n",
    "            \n",
    "        protein_sequences_data.append((seq_id, seq_org, seq_char, seq_tax, seq_seq, seq_dom, seq_loc, dom_db))\n",
    "\n",
    "    # Insert data into ProteinSequences table\n",
    "    c.executemany('INSERT INTO ProteinSequences VALUES (?,?,?,?,?,?,?,?)', protein_sequences_data)\n",
    "    \n",
    "    #build the DomainAssemblies database\n",
    "    domainarchitectures_data = []\n",
    "    for key, value in domainarchitectures.items():\n",
    "        domainarchitectures_data.append((key, str(', '.join(map(str, value)))))\n",
    "        \n",
    "\n",
    "    # Insert data into DomainAssemblies table\n",
    "    c.executemany('INSERT INTO DomainAssemblies VALUES (?,?)', domainarchitectures_data)\n",
    "    \n",
    "    \n",
    "\n",
    "    # Insert data for DomainCuration table\n",
    "    domaincuration_data = []\n",
    "    for key, value in curated_domains.items():\n",
    "        domaincuration_data.append((key, str(', '.join(map(str, value)))))\n",
    "        \n",
    "    # Insert data into DomainCuration table\n",
    "    c.executemany('INSERT INTO DomainCuration VALUES (?,?)', domaincuration_data)\n",
    "\n",
    "    # Commit changes and close connection\n",
    "    conn.commit()\n",
    "    conn.close()\n",
    "    \n",
    "    print('Database populated.')\n",
    "    return\n",
    "\n",
    "\n",
    "\n",
    "# Call functions to create the database and insert sample data\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    fastafile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_inclchar.fasta\")\n",
    "    #Fetch the protein sequences\n",
    "    proteinseq = parse_prot_seq(fastafile)\n",
    "    \n",
    "    # Create the database\n",
    "    create_database()\n",
    "       \n",
    "    populate_database(blastchar[2],proteinseq, finaldomainarchitecture, finddomainnames[1], curated_domains)\n",
    "    \n",
    "else:\n",
    "    \n",
    "    fastafile = inputfile_path\n",
    "    #Fetch the protein sequences\n",
    "    proteinseq = parse_prot_seq(fastafile)\n",
    "    \n",
    "    # Create the database\n",
    "    create_database()\n",
    "    \n",
    "    populate_database({},proteinseq, finaldomainarchitecture, finddomainnames[1], curated_domains)\n",
    "\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "e11fb4c8",
   "metadata": {},
   "source": [
    "# Protein domain co-occurence network"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 73,
   "id": "c74b28b1",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "import sqlite3\n",
    "import os\n",
    "\n",
    "#read in the database\n",
    "inputdb = os.path.join(jobname, f\"{jobname}_db.db\")\n",
    "\n",
    "def readin_db(database):\n",
    "    \n",
    "    # Connect to the database\n",
    "    conn = sqlite3.connect(database)\n",
    "\n",
    "    # Create a cursor object\n",
    "    cursor = conn.cursor()\n",
    "\n",
    "    # Execute a query to fetch data from a table\n",
    "    cursor.execute('SELECT * FROM ProteinSequences')\n",
    "\n",
    "    # Fetch the data returned by the query\n",
    "    rows = cursor.fetchall()\n",
    "\n",
    "    # Print the rows\n",
    "    #Create a identifier:sequence dictionary\n",
    "    sequencedict = {}\n",
    "    #Create a identifier:name dictionary\n",
    "    namedict = {}\n",
    "    #Create a identifier:domain architecture dictionary\n",
    "    architectdict = {}\n",
    "    #Create a identifier:domain positions dictionary\n",
    "    domainpositiondict = {}\n",
    "    #Create a identifier:taxonomy dictionary\n",
    "    tax_dict = {'BACTERIA': 'B', 'EUKARYOTA': 'E', 'ARCHAEA': 'A', 'VIRUSES': 'V', 'UNCLASSIFIED': 'U'}\n",
    "    taxonomydict = {}\n",
    "\n",
    "    for row in rows:\n",
    "        sequencedict[row[0]] = row[4]\n",
    "        namedict[row[0]] = row[1]\n",
    "        architectdict[row[0]] = row[5]\n",
    "        domainpositiondict[row[0]] = row[6]\n",
    "        taxonomydict[row[0]] = tax_dict[row[3].upper()]\n",
    "\n",
    "    # Close the cursor and the connection\n",
    "    cursor.close()\n",
    "    conn.close()\n",
    "\n",
    "    return sequencedict, namedict, architectdict, domainpositiondict, taxonomydict\n",
    "\n",
    "parsedb = readin_db(inputdb)\n",
    "\n",
    "print('Finished!')\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 75,
   "id": "e1483aec",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Counter({'(Trans)glycosidases': 69, 'Galactose-binding domain-like': 32, 'Chitobiase/beta-hexosaminidase C-terminal domain': 13, 'Golgi alpha-mannosidase II': 7, 'alpha-galactosidase from lactobacil brevis': 5, 'glycosyl hydrolase family 36 (GH36)': 4, 'Bacterial Ig-like domain 2': 4, 'Fibronectin type III': 3, 'Carbohydrate binding domain': 3, 'FIVAR domain': 2, 'AF1782-like': 2, '': 1, 'Immunoglobulins': 1, 'CBM6 (carbohydrate binding type-6) domain profile': 1, 'Glycosyl hydrolase domain': 1, 'Type II cohesin domain, interaction partner of dockerin': 1, 'Dockerin domain': 1})\n"
     ]
    },
    {
     "data": {
      "image/png": "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",
      "text/plain": [
       "<Figure size 640x480 with 1 Axes>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "import networkx as nx\n",
    "import matplotlib.pyplot as plt\n",
    "from collections import Counter\n",
    "\n",
    "#Create a protein domain co-occurence network\n",
    "\n",
    "# Example dictionary\n",
    "protein_domains = parsedb[2]\n",
    "\n",
    "# Create a domain co-occurrence network\n",
    "G = nx.Graph()\n",
    "\n",
    "# Process domain architectures and create co-occurrence edges\n",
    "for protein, architecture in protein_domains.items():\n",
    "    domains = architecture.split('--')\n",
    "    for i in range(len(domains) - 1):\n",
    "        G.add_edge(domains[i], domains[i + 1])\n",
    "\n",
    "# Count domain occurrences\n",
    "domain_counter = Counter('--'.join(protein_domains.values()).split('--'))\n",
    "print(domain_counter)\n",
    "\n",
    "# Create a list of node sizes based on domain occurrence count\n",
    "node_sizes = [domain_counter[domain] * 100 for domain in G.nodes()]\n",
    "\n",
    "# Create the network visualization\n",
    "pos = nx.spring_layout(G, seed=42)  # Layout algorithm\n",
    "\n",
    "# Draw nodes and edges\n",
    "nx.draw_networkx_nodes(G, pos, node_size=node_sizes, node_color='skyblue')\n",
    "nx.draw_networkx_edges(G, pos, edge_color='gray', alpha=0.7)\n",
    "\n",
    "# Add labels to nodes\n",
    "labels = {domain: domain for domain in G.nodes()}\n",
    "nx.draw_networkx_labels(G, pos, labels, font_size=10, font_color='black')\n",
    "\n",
    "# Set edge attributes for edge thickness based on interaction count\n",
    "for edge in G.edges():\n",
    "    source, target = edge\n",
    "    interaction_count = min(domain_counter[source], domain_counter[target])  # Minimum occurrence count between nodes\n",
    "    G.edges[edge]['width'] = interaction_count\n",
    "\n",
    "\n",
    "# Draw edges with variable thickness\n",
    "edge_widths = [G.edges[edge]['width'] for edge in G.edges()]\n",
    "nx.draw_networkx_edges(G, pos, width=edge_widths, edge_color='gray', alpha=0.7)\n",
    "\n",
    "\n",
    "#show the network in this Notebook\n",
    "plt.title(\"Domain Co-Occurrence Network\")\n",
    "plt.axis('off')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 76,
   "id": "ec736d9b",
   "metadata": {},
   "outputs": [],
   "source": [
    "#Save the network to a GraphML file for Cytoscape\n",
    "\n",
    "# Create a dictionary of node sizes based on domain occurrence count\n",
    "node_sizes = {domain: domain_counter[domain] for domain in G.nodes()}\n",
    "\n",
    "# Set node attributes for GraphML\n",
    "for node, size in node_sizes.items():\n",
    "    G.nodes[node]['size'] = size\n",
    "\n",
    "# Save the network in GraphML format\n",
    "file = os.path.join(jobname, f\"{jobname}_domain_cooccurence_network.graphml\")\n",
    "nx.write_graphml(G, file)\n",
    "\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "523e1e7d",
   "metadata": {},
   "source": [
    "# Exclude sequences without domain result"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 77,
   "id": "1a9184fd",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "['UVO70768.1']\n",
      "68 sequences will be used for MSA and PTI.\n",
      "For following proteins no domains were found: ['UVO70768.1']. These will be excluded from the subsequent analysis.\n"
     ]
    }
   ],
   "source": [
    "#only perform MSA and PTI for sequences which contain at least 1 domain\n",
    "\n",
    "if go == True: \n",
    "    inputfile = os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_inclchar.fasta\")\n",
    "else:\n",
    "    inputfile = inputfile_path\n",
    "    \n",
    "outputfile = os.path.join(jobname, f\"CAZy_{jobname}_inclchar_selected.fasta\")\n",
    "\n",
    "def select_sequences(inputfile, domaindictionary, go, execute = True):\n",
    "    \"\"\"This function creates an outputfile containing sequences that contain at least one domain.\"\"\"\n",
    "   \n",
    "    no_domains = []\n",
    "    output = ''\n",
    "    for key,value in domaindictionary.items():\n",
    "        if value == []:\n",
    "            no_domains.append(key)\n",
    "    \n",
    "    for seq_record in SeqIO.parse(inputfile, 'fasta'):\n",
    "        identifier = seq_record.id[:seq_record.id.find('.')+2]\n",
    "        if identifier not in no_domains:\n",
    "            output += '>' + seq_record.id + '\\n'+ seq_record.seq + '\\n'\n",
    "            \n",
    "    if go == True:\n",
    "        charseq = os.path.join(jobname, f\"Characterized_{family}_{taxsubset}_FASTA_sequences.fasta\")\n",
    "        for seq_record in SeqIO.parse(charseq, 'fasta'):\n",
    "            identifier = seq_record.id[:seq_record.id.find('.')+2]\n",
    "            if identifier in no_domains:  \n",
    "                print(f'Warning: Following characterized protein will be excluded from subsequent analysis {identifier}.')\n",
    "    print(no_domains)\n",
    "    return output, no_domains\n",
    "\n",
    "domaincontainingseq = select_sequences(inputfile, finaldomainarchitecture, go, execute)\n",
    "with open(outputfile, 'w') as file:\n",
    "    file.write(str(domaincontainingseq[0]))\n",
    "\n",
    "print(f'{sizefastafile(outputfile)} sequences will be used for MSA and PTI.')\n",
    "print(f'For following proteins no domains were found: {domaincontainingseq[1]}. These will be excluded from the subsequent analysis.')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "1fa04b37",
   "metadata": {},
   "source": [
    "# MSA: MAFFT"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 78,
   "id": "c19fa31d",
   "metadata": {},
   "outputs": [],
   "source": [
    "from Bio import SeqIO\n",
    "from Bio import AlignIO\n",
    "import os\n",
    "\n",
    "from subprocess import Popen, PIPE\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 79,
   "id": "9ceb6174",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      ">ATO84721.1_Actinoplanes_sp_SE50_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MR------------------------------------------------------\n",
      "-----NRL--------------------------------LPLALTALTL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------V-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------------------GP---------\n",
      "-------------------------------------P----APAGAAR---SPAEPV--\n",
      "AGTWIGFGYNQDPQ-YAGGTGT----------PTPW-DPRAF-QRMTERTTFIRPPIVRV\n",
      "MLNRDWFNPTGVAGR----------YEW------ASVQMTNLYQVLTHYRSLGT-RVQLG\n",
      "L-WGVQPS-------------------SAVN-------------PYTATETATVQADLMR\n",
      "RLYVTDAYTNIVRYTGVNEPNVK--NEAKN----------YS--------YADWVTATTN\n",
      "LRAAFAAE-NLPV---TLLGGPDTAEATISGQDGDLGLESVTGGAAATGQNAVWRADGLA\n",
      "GFDATFYVSPDTGAADWKFYTSRDGSSWAQLDPASLVQSAPVKTVATNPWYRYEVRNGAP\n",
      "LAAGTDYLRITLPAHAGTERALASLTMTTGAGGTVADPMNDWSHATSHSSGWTHLQGAPT\n",
      "DDWWLEAAGSSLVSG-----LQTHFYAHEL-------------DLADAGYPVQQLQEYPE\n",
      "ATLREAVRQVRAA---APGVPVILGETGMKAPK-------------------------ST\n",
      "DGKDYAFTDEPE-------HGVRMADLAVQEVRAGVDGAMAWCLDGYAAAV---------\n",
      "-----------------------------------QCG----MWDHEGT-----------\n",
      "-------TEATTALRPWFYTWSLLCRYLP-AGSTLYAPAQ--------------------\n",
      "--------------------------------------------------Q-PGLRLLQA\n",
      "Q-------APGSG---GWTFVLVNRG-TTAVTVPMTAPT-------GKVTFHRYLYQAAA\n",
      "N------PPGPVDADG--------FPVPAGTFLG-SFDGGR--PVTV-PADAVVLITSMS\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">BBL06275.1_Alistipes_dispar_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MGCGVQWDPY-DVHGDG------------GRL-SAADR-IRLEKRLDYLSPRIIRV\n",
      "MVSIGSYL---TDGRFDP-----------------ASDMEDLHMILGYCTGRSI-PVVFG\n",
      "D-WGGGFV-------------------DVAA-------------KTVDENRMEQSAKLVR\n",
      "YLLEDCGYTCIRYFNMVNEPNGS--WSSTQ---------G-D--------CDLWVRAARA\n",
      "MHASLRRC-GLG--DRVTLVGPDAAVWTT-------------------------------\n",
      "------------AETHWVSRTAD-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------ELGD-AVGL-----YDIHTYPSKA-------------EINAGEY---------G\n",
      "EMIAAYRAAAP------AERRMIVGEIGIKFID--E-RDAAYAAENERRAARCPY---AS\n",
      "PADSQMSVFDHM-------YGTDMADAIMQTAANGYSGCIVWMLDDAMHVN---------\n",
      "-----------------------------EPGRLKIWG----FWNILGEERY--------\n",
      "-------GASAERIRPWYYAVALLSRYFP-AGSQILESTV-RG-----------------\n",
      "--------------------------------------------------V-PGVRTMWG\n",
      "R---------SDG---KPTLAIVNTS--RDRAVELTLEGADS----SLAGLDRYLYAEGG\n",
      "L---------KLDEER---------LLPVDE--RIALRSGD--RIRI-DPGSMVVYTALE\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">BBL01040.1_Alistipes_onderdonkii_subsp_vulgaris_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MLT------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------------------LSGRVI--\n",
      "DDAYIGNGVQWDPY-EVHDVD------------GRF-SAADR-KRLTDRLEYMQPRFIRV\n",
      "MGGIRSYL---TDGRFDP-----------------SRNMEDLHMILGFCNTHGV-TVLLG\n",
      "D-WGGSLV-------------------DRQA-------------QTVDQALIDSSGEMVR\n",
      "YLVEECGYDCIRYYNIVNEPNGS--WASTR---------G-D--------YALWLRAARA\n",
      "MDASLRRH-GMA--GRVKLVAPDAAVWTT-------------------------------\n",
      "------------LETHWVSNSVR-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLGD-AVGL-----YDIHTYPSKA-------------QVNTGEY---------S\n",
      "AMISAYRAAAP------AGTKMILGELGLKFID--E-RDVAYAAENERRIAADPD---AS\n",
      "PGDSQMFVFDHM-------YGIDVADAVMQTAACGYSGCVVWMLDDAMHMN---------\n",
      "-----------------------------EPGKLKIWG----FWNILGEERY--------\n",
      "-------GAGKERIRPWYYAMSLLCRYFP-QGAQILASGV-SG-----------------\n",
      "--------------------------------------------------V-GGVRSMFG\n",
      "R---------TEK---GVTLAVVNTD--SERTVELTLENPQP----GLSDLALYVYAPGR\n",
      "L---------RLGGER---------LLPVER--GVALAPGS--RISL-APETMLVYTSME\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UWN65549.1_Alistipes_senegalensis_JC50_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MR---------QTKTV----------------------------------------\n",
      "----------------------------------------RTLLLALLAL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AG------------------\n",
      "-------------------CSASLAESN--------------------------------\n",
      "---------DDER--------L--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------PESTRTPGY---E----SGASLEV---RVGRST--\n",
      "GVTLAGLGVELDPH-FLSQNVT---------RHDGA-KASDWDEIVVPRIRKMGIQRFRV\n",
      "MLLPHWW--EPLNDNGDPGVAALDRFTF------ESAEMRSLYKVLDIAQEMNA-DVTLV\n",
      "L-WGCPTYCDLLDPAYAGVKRHFLCSSEGTN---------WVVEPADSEEFAESFSTVVK\n",
      "HLIERRGYTCIKELTPFNEPDGN------------------------IIPLERYVPLAKV\n",
      "LDRRLRAD-GIR--DKVRLNLSDNTD----------------------------------\n",
      "------------TRHFFLEGCAR-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------ELSQ-EADL-----FNSHTYIFGY-------------DTPNSTV---------L\n",
      "AWEEANVAAAA-----TAGKNHFVGEFGSNQCVG--------------------------\n",
      "-ATRQTDIDRYD-------RGVLMTRLVVNFLNAGAVGTSYWSLIDQYYGR---------\n",
      "---------------------------NESYAAMQQLG----MWRYMRAAYRQDPDP---\n",
      "--GVYDRLTDDYQPRPQYYAYSLLTRFIR-KGSEVYPLDL-GN-----------------\n",
      "----------------------------------------------------EFAAGTAV\n",
      "R--------AAAG---RWTYVIANAT-DETLSFDLKNTLR-G----GMSACKVYVYEERR\n",
      "L---------PDGDEL---------IAPSLQLENSGGT----FCVGV-KARSVIVLTQL-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">CBK63196.1_Alistipes_shahii_WAL_8301_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------NF------------------------------------------\n",
      "----------------------------------------GNLLLACMAA----------\n",
      "------------------------------------------------------------\n",
      "------------------------------L-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------L--GA------------------\n",
      "-------------------CAGESAG----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------K----CDAVVRI---DADSVV--\n",
      "NRGYIGNGVQWDPY-ALDYGQ----------GRVEI-SDADW-AKLYARLDFMRPAFIRV\n",
      "MTNTTSVV---RNGRLDR-----------------MRGFEHLSHILGYCQSHGV-TVMFG\n",
      "D-WGGSLM-------------------DARA-------------GTVNRTLLDHAAAYVA\n",
      "WLVGEKGYDCIRYYNLVNEPNGF--WSAAD---------G-D--------FDLWAKAVSY\n",
      "FRGRLDAE-GLA--GKVELVGPDAAIWGP-------------------------------\n",
      "------------EEAWWVSRSRD-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------ELGD-RIGL-----YDIHTYPSKC-------------TVNSGEY---------T\n",
      "RILEAYRREVP------AGKKIVMGEIGFKFVE--P-ADSLLQAENLRRAAAHPN---AS\n",
      "TDDSQMFVYDPM-------YGTDMADALFQTIHAGYSGCIAWMLDDAMHFK---------\n",
      "----------------------------EAPDKLKIWG----FWNIFGDEIF--------\n",
      "-------GAGEERVRPWYYAWSLLCRTLR-PGSDFFAANV-RG-----------------\n",
      "--------------------------------------------------A-AGVKAVAA\n",
      "V---------KDG---RRTVAVVNVS-REPRRVRIECPGW-E----RFRQATRYRYGEGL\n",
      "M---------RTEGDH--------TLLPDATGLRIDFRSGA--EYDM-PGESMILLTEQN\n",
      "D-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UZO80939.1_Aquimarina_sp_ERC38_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MLK----------NI---------N-Y------------------------------\n",
      "----------------------------------------KYVLLLAFLV----------\n",
      "------------------------------------------------------------\n",
      "------------------------------T-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------G--IS------------------\n",
      "-------------------CSDDFEA----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------PA--------\n",
      "-----------------------------------EEP----ISTELVI---ELGTVI--\n",
      "NDSYIGNGVQWDPY-PQAYKF----------WDLPI-QDVDW-QKMYDRLDYMKPSFLRV\n",
      "VFGSYDKYAHLGADNYNP-----------------IIFLEGMERILQYCQDNNI-TVMLG\n",
      "D-WGYNQM-------------------DVNQ-------------NRIFENRITNAAKYVK\n",
      "FLVEEKGFTCIKYYTTVNEPNLE--GSATE---------G-D--------YDLWKRTTEA\n",
      "FYRKLDSL-GVS--SKVKLAGPDIAPFSD-------------------------------\n",
      "------------NLTNWVTDMTA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLGD-KVKL-----YDIHTYPPKE-------------AMYNGVY---------E\n",
      "RTLAAYKNAAP------AGTPIVIGEYGFKYETGTSQIDQNLYNANLENINSSAN---IA\n",
      "-LDSNTLVDEYF-------HGVDLIAATMKIVNAGYSGAINWNLDDAMHSG---------\n",
      "-------------------------SNSGQ--DLKVWG----FWNILGVEILG-------\n",
      "-------NPQKEEVRPHFYSFSLISRYMQ-NGTKVFKVNI-PR-----------------\n",
      "--------------------------------------------------L-VGVDAIAV\n",
      "E---------NDG---KYMIAINNIF-SEDYEINVKAIGL------SLSGAKKFVYKEND\n",
      "R---------TVDVNG--------YPTPEEENLSYDFSAGE--TLSV-PGTTLTVITNFD\n",
      "Y-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UZO80937.1_Aquimarina_sp_ERC38_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MMR------------------------------------------------------\n",
      "--S-------------------------------------TLLFLVFVVL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------L-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------LT-VN------------------\n",
      "-------------------CNEKVGE----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------SAFAK----AGISLSF---LKENTI--\n",
      "NTQFLGHGVQWSAY-PHADSEDA-------EWGFLM-TDEKW-EELYRRLDFVNPHVIRV\n",
      "MDGAGWRYYQGNDKDGNPI------VDY------NTQEVKSLYKLLDYCQKNDI-KVMFG\n",
      "E-WGAPQSGS--------------KVKNPID-------------RADDDRWIEMITGYLN\n",
      "HLVIEKGYTCITYYNLVNEPNGY--WASTD---------G-D--------WDQWSAGYTK\n",
      "MAKALANS-PLS--KYVGMVGPDATVQWN-------------------------------\n",
      "------HPTHPKPSADWMYSTIE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------EHNE-ITKA-----YEVHIYANQD-------------EIRSGNL---------I\n",
      "KFLQPFADSLK-----NIDKPFLLGEIGMKYNG-------ELGEENKKRAAADPY---AS\n",
      "TEDSEMFVYDHF-------YGVDMADAAAQSMLVGMGSAIAWNVDDAMHTK---------\n",
      "-------------------------GDAGEKSKLKKWG----MWNILGEH-FN-------\n",
      "-------GPDELTPRPWSYPWTVLCNIFP-PGSKVMKPII-NVK----------------\n",
      "--------------------------------------------------N-DSIRAVGA\n",
      "Y---------KND---MFSMMLVNQS-KTGQTYNVATDTY-T----NGVPLYLYNYVDGE\n",
      "N---------IKNSSG--------FPVPARE-VTYKKDLGV--QVEL-PANSVVFISTIK\n",
      "LK----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">AGY53053.1_Bacteroidales_bacterium_CF_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MMK------------------------------------------------------\n",
      "-----------------------------------------NLLLSLLLI----------\n",
      "------------------------------------------------------------\n",
      "------------------------------T-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------GL-AS------------------\n",
      "-------------------CTT--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------NATIITI----SPKVS--\n",
      "NPDIIGNGAEWDPY-CEAVQ-----------WGSPL-TDQMW-ATIFERTDKMGMSIVRC\n",
      "MINSPFRYYDKKTGSFK-----------------KEQNSESLLKVLEYCQKNNI-AVMYG\n",
      "E-FNPPAPE-----------------------------------LKKDPKWIKMSIEYLN\n",
      "YLVADCGFTCIRFFIPTNEPDGN--WSMYD---------G-D--------YQMYRDIVEM\n",
      "FNKEIKSYPALA--SHIRFAAPDVVLGYK-------------------------------\n",
      "------NPKYDMDNSAWISRTS--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------EIDS-LVGV-----YEIHAYPGYK-------------QVRSGEF---------A\n",
      "RMFREVAQSVP------KGKKIILGEAGYKPGR--E-EDSLENKSHFERLQATPLIENKE\n",
      "GADCNMRVYDFE-------YGLDMALLAMEVMNNGGAGVAVWMLDDS-HSV---------\n",
      "-------------------------GDTGEAKNLKIWG----MWNIFGEKVWK-------\n",
      "-------MKDEEKIRPWYYAWSLMCKYFP-AGSDILTPGE-IL-----------------\n",
      "--------------------------------------------------D-KDIKVVAA\n",
      "V---------KDD---KLTIALLNLS-TEKKVLHINLPK-------TIQNASMYTYKKDT\n",
      "G---------VND----------YSLDPARSGLTAEKV----LKTDI-AACSLLVVTEL-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ANU59401.1_Bacteroides_caecimuris_B\n",
      "MA----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK---------MTHIS----------------------------------------\n",
      "----------------------------------------KTLLSIVCTL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------W----------------------------\n",
      "-----------GM---------------------------SA------------------\n",
      "-------------------CSDDYNK----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------YDDCP----ACNYYPV---AVGNST--\n",
      "GTPVHAIGVEMDPH-FFSQNIT---------RNDGS-KAEDWENIVVQRVKKMKVQQFRI\n",
      "MMQPQWW--EPSNDNNDPNVADMSKFTF------DSEEMQSVYKVLDMAQENNI-GVTLV\n",
      "V-WGAITNIDLLSGINNG-QKHFLCDARSYNV--NP---GWIAGIDNYEEFAENFSTMVK\n",
      "YLIEEKHYTCINQITPFNEPDSH--IAGYGRI----MWQG-DFE--TMGWQDTYAPMVKA\n",
      "LDAKFKAD-GIR--SKVHFNLSDNTD----------------------------------\n",
      "------------GTPGYIAACVS-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------AFTNDEADL-----YNSHVYKFDY-------------NTPNSTL---------V\n",
      "NWERQNIAS-------AGGKRHFVGEFGFPGYG---------------------------\n",
      "-SARQYGIDTYT-------RGVQLIRVALNYLNAGACGVSYWSLIDQYYNR---------\n",
      "---------------------------NASYSEMQQLG----LWKYLKSAYTEDPD----\n",
      "---VYSKIKEDYEVRPQYYAYSLLTRFVR-QGDEVYPLDL-GD-----------------\n",
      "----------------------------------------------------ELIAGSAF\n",
      "L--------NTEG---KWTYVLSNAT-DKDKMIQLENDKE-G----ANGEYNVYKYMEGR\n",
      "L---------PEGDNL---------IESTETVNTQENN----LKLKL-SRSSIRVLVQK-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ANU59398.1_Bacteroides_caecimuris_B\n",
      "MKKRILYYLFI----LLLFPHNGTGQTVARMSDRPVNTSQWITTHFARGVVPPFSFEYEG\n",
      "KPSQEFIKNWSYTATRQKSDDPKVLKYLYTYREPSGGLKVECEVKGFTDFNTVEWVLRFT\n",
      "NQGKKNTPEIANVKVSDITFRYQHPGVFNLHHSEGSHA----SKSDFSQQLTILSPGD--\n",
      "-NLYMRPEG-GRSS-QMRMPFFNIESPANQGVIVAIGWTGTWFADVRCADQQSV-----A\n",
      "LTSGIERLKTY-------------------------LYPEESIRTSSVCL-----SFWNG\n",
      "SDRMKGHNQFRRFVQAHHT--WKVGGKP--TVYPIST--SFNYGDPTPCNEYTCLTTDYA\n",
      "IAMVKRYEQFKL-VPEVFWLDAGWYNHSADVANHKNWANTVGNWTVDSIRFPEGLRPIAD\n",
      "EVHRVGSKFMVWFEPERVMKGSAWALQHPQ-WMLDARGKAKQEDWTRDGEHDSYLFNLGN\n",
      "PEACRWMSKYIGDFLEENGIDYYRQDF-----NIEPEGFWAANDEPGRQ-GICEIRYIEG\n",
      "LYSFWEYLLNRFPGLLVDNCASGGRRI---------------------------------\n",
      "---------DLES--------ISRSAPMWRTDYSYGEPIGYQ-CHTYGLNLYLPLHGTGT\n",
      "VSADKFTFRSSLGTS---IIYNWKITEAGQSIYDMRDRQAEFKELRPYFYEDYYPLSGIN\n",
      "NITSENI------WLAYQLYRPSDDSGYIVAFRRKDNPDKSYTVNLSGLHPDHTYILTNK\n",
      "DTGEAIKKTGKELANGFTLTLD--NPQSSLIIKYQS-S----TTAIQKL---SVGKKT--\n",
      "GVKLRAIGAELDPH-FLSQNVT---------RNDGA-KAEDWERIVVKRVKEMGLQSLRV\n",
      "MVMPQWY--EPKNDNPDASKIDWHNFTF------NSVEMQSLYKVLDMAQEQKM-EVTLV\n",
      "L-WGAP-------------PGHFLAEGNYGN---------WVVAPTNYEEWSENFSALVQ\n",
      "HLLNNKKYTCVKEITPINEPDWS--YIIKGK----------------AAPTADYIEMCKV\n",
      "LDRRFKED-GIR--NKVHFSLSDNSDGGT-------------------------------\n",
      "------------GTHKYLAACTK-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GLAN-VADV-----FNSHTYIFGY-------------ETPNSTI---------L\n",
      "DWEKQNSQLAS-----SVGKAHFIGEFGGNQCVG--------------------------\n",
      "-ATRQKDIDLYE-------RGVLMTRIAINLLNAGASGVSYWSLIDQYYGK---------\n",
      "---------------------------DADYGAMQQLG----LWKYVKKTYASEP-----\n",
      "---YYNDIKSDYEVRPQYYAYSLLTRFIR-PGAEIYPIAT-PE-----------------\n",
      "----------------------------------------------------EWYAGTAV\n",
      "R--------NTNG---KWVYVFASGM-DQEKAISLINQHT-Q----TKGNYQVYRYIKDG\n",
      "L---------PTTDQM---------LAPDAQPLKVNDK----ILCLL-PAHSVIVLKQE-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UBD71149.1_Bacteroides_cellulosilyticus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK------------------------------------------------------\n",
      "----------------------------------------RFAILSVFFL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------WG------------------\n",
      "-------------------GYA--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------A----SQTVVSV---DTKQII--\n",
      "NEGYIGNGAQWDPY-QLDYGK----------GRLDI-SEADW-KKMYDRLDFMRPQFIRV\n",
      "MTNTTSVM---QDGVLYP-----------------ERGLEHLSHILDYCQSRDV-TVMFG\n",
      "D-WGGGMV-------------------DARK-------------EMIREKNLSAAAEYVR\n",
      "FLIEEKGYSCIKYYNLVNEPNGY--WSSTD---------G-K--------YSLWARAIRF\n",
      "FYGELQKN-KLA--GKLSVVGPDAAIWTA-------------------------------\n",
      "------------DEAWWVDSCAT-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------HLKD-EIGL-----YDIHTYPSKI-------------TVNSGEY---------T\n",
      "DIIRAYKQAVP------AGRKIVMGEIGFKFVE--P-ADSVYQRENLRRAAAKPY---AS\n",
      "MDDSQMFVYDFM-------YGTDMADALFQTVNAGYSGSVVWMLDDAMHAK---------\n",
      "----------------------------EAPDKLKVWG----FWNIFGEEYF--------\n",
      "-------GTEEEEVRPWFYAWSLLTRYMP-AGSRAYKVEV-EG-----------------\n",
      "--------------------------------------------------D-KSLKAIAV\n",
      "E---------KDG---KYMIAVVNVS-REEKSVLLKSTSL-P----VLKGVKQYLYAEGR\n",
      "L---------QKEGDC--------RLLPHRQGMTLRPAEGE--AFQM-PGESLVVYTNFD\n",
      "Y-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QUT88730.1_Bacteroides_cellulosilyticus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK------------------------------------------------------\n",
      "----------------------------------------INMILSCMLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------WLVSA------------------\n",
      "-------------------CTS--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------Q----EVVEITV----SPEVT--\n",
      "NAGYIGNGAEWDPY-DEAEA-----------WGASI-SDKDW-ETLCKRLDFMKPQYIRC\n",
      "MINSPYRYYDSETGTYD-----------------KTRNIASISRLLRYCTERGI-TVMYG\n",
      "E-YNPPTWD-----------------------------------MKQDQKWVDMSVDYLN\n",
      "YLVNDLGFSCIKYFVIFNEPDGN--WASTN---------G-D--------YEMWKQMLFR\n",
      "FHRKMKEYPGLT--EKVMLAGPDVVADYK-------------------------------\n",
      "------NEASAYDAEGWVKQTAL-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DADS-IIGL-----YDVHAYPGQN-------------EVRTGQY---------P\n",
      "EILSRYKRHVP------EGKKIVLGEAGYKYWR--D-ADSLLMAEYNRRVEGHPF---TK\n",
      "GSDCNMLCYDYF-------YGLDMPLLAMEVMNGGYSGMAVWMLDDAMHSS---------\n",
      "-------------------------GDSGKTEDVKIWG----MWNILGEEVFN-------\n",
      "-------KPDEEQIRPWFYTWSLMCRYFP-AGTDILHTAV-ASE----------------\n",
      "--------------------------------------------------D-KDVYVVAG\n",
      "T---------YQG---KLTVAMVNVG-EKDKSVQLTLPR-------PMENASLYKYEENL\n",
      "Q---------PKDADG--------FPVPQETGFHLKGT----YKTTL-KAQTFQLLTDIQ\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UWN88717.1_Bacteroides_eggerthii_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK---------RNIFLS---------------------------------------\n",
      "----------------------------------------CAALLAASVF----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AS------------------\n",
      "-------------------CYKDDHQPP--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------MVEGGH----AGVDFVI---DNNKVI--\n",
      "TDNFLGFGTQYNNN-LYTTRTF---------ENDGV-SEENL-PDLEKKVLALGSQYVRI\n",
      "FFDKKNW--ESVSG-------------Y------NPEYKASFIRTVELAQKTGA-LVNIT\n",
      "Y-W-----------------------------------------HSSIPEDMGRFADEIY\n",
      "DLIVNKGLTCVKQVTIQNEVNST----------------KIT--------PDEYRVLYSV\n",
      "FIDRLKEL-GIR--DKIQLVGGDLVQD---------------------------------\n",
      "------------NQKTWFEYMST-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------SMAT-LLDG-----YSSHIYWDYW-------------DKVK-----------PV\n",
      "DRLSGVADLLSN-MQGQGIKPCYITEYGVRGEK----SGGAFNNPGYLRGTDTPI-----\n",
      "-------GRTNE-------CALRHVTFHINALNYGFAGLVKWDCYKAKYDN---------\n",
      "-------------------------------------GN--QYFPVIGS-----------\n",
      "-------GTDGYPLYPSYWMTWAFTHSCQ-PGWKVLSATS-VV-----------------\n",
      "--------------------------------------------------S-SAHKLCAA\n",
      "M---------SDGV-SNYTIYAQTTA---TVQTPFVISGI-P----ANKKFRVLAWNDDL\n",
      "MGGLTELEPVTSDAEG-----------------------VV--RFNV-KPDGFITLTTID\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------FTLPEGLE-----------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UVR10658.1_Bacteroides_ovatus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------MSDITFRYQHPGAFNLHHSEGSHA----SKSDFSQQLTILSPGD--\n",
      "-NLYMRPEG-GRSS-QMRMPFFNIESPANQGVIVAIGWTGTWFADVRCADQQSV-----A\n",
      "LTSGIERLKTY-------------------------LYPEESIRTSSVCL-----SFWNG\n",
      "SDRMKGHNQFRRFVQAHHT--WKVGGKP--TVYPIST--SFNYGDPTPCNEYTCLTTDYA\n",
      "IAMVKRYEQFKL-VPEVFWLDAGWYNHSADVANHKNWANTVGNWTVDSIRFPEGLRPIAD\n",
      "EVHRVGSKFMVWFEPERVMKGSAWALQHPQ-WMLDARGKAKQEDWTRDGEHDSYLFNLGN\n",
      "PEACRWMSKYIGDFLEENGIDYYRQDF-----NIEPEGFWAANDEPGRQ-GICEIRYIEG\n",
      "LYSFWEYLLNRFPGLLVDNCASGGRRI---------------------------------\n",
      "---------DLES--------ISRSAPMWRTDYSYGEPIGYQ-CHTYGLNLYLPLHGTGT\n",
      "VSADKFTFRSSLGTS---IIYNWKITEAGQSIYDMRDRQAEFKELRPYFYEDYYPLSGIN\n",
      "NITSENI------WLAYQLYRPSDDSGYIVAFRRKDNPDKSYTVNLSGLHPDHTYILTNK\n",
      "DTGEAIKKTGKELANGFTLTLD--NPQSSLIIKYQS-S----TTAIQKL---SVGKKT--\n",
      "GVKLRAIGAELDPH-FLSQNVT---------RNDGA-KAEDWERIVVKRVKEMGLQSLRV\n",
      "MVMPQWY--EPKNDNPDASKIDWHNFTF------NSVEMQSLYKVLDMAQEQKM-EVTLV\n",
      "L-LGAP-------------PGHFLAEGNYGN---------WVVAPTNYEEWSENFSALVQ\n",
      "HLLNNKKYTCVKEITPINEPDWS--YIIKGK----------------AAPTANYIEMCKV\n",
      "LDRRFKED-GIR--NKVHFSLSDNSDGGT-------------------------------\n",
      "------------GTHKYLAACTK-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GLAN-VADV-----FNSHTYIFGY-------------ETPNSTI---------L\n",
      "DWEKQNSQLAA-----SVGKAHFIGEFGGNQCVG--------------------------\n",
      "-ATRQKDIDLYE-------RGVLMTRIAINLLNAGASGVSYWSLIDQYYGK---------\n",
      "---------------------------DADYGAMQQLG----LWKYVKKTYASEP-----\n",
      "---YYNDIKSDYEVRPQYYAYSLLTRFIR-PGAEIYPIAT-PE-----------------\n",
      "----------------------------------------------------EWYAGTAV\n",
      "R--------NTNG---KWVYVFANGM-DQEKAISLINQHT-Q----TKGNYQVYRYIKDG\n",
      "L---------PTTDQM---------LAPDAQPLKVNDK----ILCLL-PAHSVIVLKQE-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UVO70767.1_Bacteroides_ovatus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------------MTLV\n",
      "V-WGAITNIDLLSGINNG-QKHFLCDARSYNV--NP---GWIAGIDNYEEFAENFSTMVK\n",
      "YLIEEKHYTCINQITPFNEPDSH--IAGYGRI----MWQG-DFE--TMGWQDTYAPMVKA\n",
      "LDAKFKAD-GIR--SKVHFNLSDNTD----------------------------------\n",
      "------------GTPGYIAACVS-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------AFTNDEADL-----YNSHVYKFDY-------------NTPNSTL---------V\n",
      "NWERQNIAS-------AGGKRHFVGEFGFPGYG---------------------------\n",
      "-SARQYGIDTYT-------RGVQLIRVALNYLNAGACGVSYWSLIDQYYNR---------\n",
      "---------------------------NASYSEMQQLG----LWKYLKSAYTEDPD----\n",
      "---VYSKIKEDYEVRPQYYAYSLLTRFVR-RGDEVYPLDL-GD-----------------\n",
      "----------------------------------------------------ELIAGSAF\n",
      "L--------NTEG---KWTYVLSNAT-DKDKMIQLENDKE-G----ANGEYNVYKYMEGR\n",
      "L---------PEGDNL---------IESTETVNTQENN----LKLKL-SRSSIRVLVQK-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QGT72561.1_Bacteroides_ovatus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------KY------------------------------------------\n",
      "----------------------------------------FFIFIVAFF-----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AS------------------\n",
      "-------------------CSP--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------VE----QDVIITI---DTETVL--\n",
      "NDCYIGNGAQWDPY-QLDYGK----------GKLTI-SEADW-EKLYDRLDFMRPQFIRI\n",
      "MINTSSFV---DQGRLVP-----------------ERGMEVLSKMLDYCQSRNV-TVMFG\n",
      "D-WGWSVI-------------------RARE-------------AEIDSQSLRHAAALVD\n",
      "YLVHNKGYSCIRYYNLVNEPNGY--WAATN---------K-S--------FPLWASSVRQ\n",
      "FYQYMKEF-DLI--GEVGIVGPDIAIWDK-------------------------------\n",
      "------------AETGWMDSCAV-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------QLNE-QIEL-----YDIHTYPSKV-------------TVNSGEY---------A\n",
      "DIIAAYKEKIP------ERKKIVMGEIGFKFVE--K-ADSLYQKENIRRARSKVN---AS\n",
      "LEDSQMFVYDYM-------YGTDMADALIQTVNTGFSGSIAWMLDDAMHSN---------\n",
      "----------------------------EAPDKLKIWG----FWNIFGEECF--------\n",
      "-------GAEEENVRPWYYAWSLLTRYMP-AGTAVYRTDT-TG-----------------\n",
      "--------------------------------------------------E-PFVKAAVS\n",
      "G---------KDG---KYMIALVNVS-DSPKTVKLKSDVL-S----SLSGCKKFIYSDGT\n",
      "L---------KQKGDC--------LLLPNDENLILHLEKGE--TVTM-PAESLIVYTNYD\n",
      "Y-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UWO00929.1_Bacteroides_sp_D2_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK------------------------------------------------------\n",
      "----------------------------------------VLLQILFLLF----------\n",
      "------------------------------------------------------------\n",
      "------------------------------C-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------IG------------------\n",
      "-------------------CQKPVQ-----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------N----AEVIFRI---NKDSII--\n",
      "STSYLGNGVQWDPY-QLDYGN----------GRVTI-SESDW-NKLYARLDHMRPQFIRM\n",
      "MVYTTDYL---KNGKLDE-----------------MYDFDQVSKILTYCQERGI-TVMMG\n",
      "D-WGGRMV-------------------DPVT-------------NRIDTFMLSNAARYAD\n",
      "FLVNRKGYDCIKYYNMINEPNGD--WSSNQ---------A-N--------YDLWARAIRY\n",
      "FDRRMHDY-GLA--DKVGLAGPDAAIWDQ-------------------------------\n",
      "------------SEAWWIDSCAT-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------RFNE-AIKL-----YDIHTYPPKS-------------TVNSGEY---------S\n",
      "KIIRAYKERVP------QGSQIIMGEIGLKFLK----TDTLLEKENNERISKVPH---AS\n",
      "REDSQMFVYDHF-------YGIDMADALFQTMNEGFSGALIWMLDDAMHSK---------\n",
      "-------------------------TE-EGPDKLKIWG----FWNILGEEYFG-------\n",
      "-------GAKEEEVRPSYYAWSLLSKYIP-KGSTVYAVET-GE-----------------\n",
      "--------------------------------------------------D-KGVRAVAV\n",
      "E---------HKG---KYTIGVVNVS-GQERTVLFKSNSL-P----VLEDIRQYNYIENE\n",
      "I---------LKEGDC--------KQLPNVTGIKLNLEKGL--FLEL-PTDGLVVYTNME\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UWO00930.1_Bacteroides_sp_D2_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------NI------------------------------------------\n",
      "-----------------------------------------IKGLICLAL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------F-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------L--SG------------------\n",
      "-------------------CGKDNGGDT--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------PP--------\n",
      "-----------------------------------VPE----PDVNTLL---VTPKVL--\n",
      "TNSYLGNGPQWGGY-DIVNAWT---------GNATL-SEQDW-NTLFKRVSFMRPSLIRI\n",
      "MVSQGWNYMNG--EVYSP-----------------EKSDPVLGKILSYCQEKGI-TVQLG\n",
      "E-WGHVGG------------------------------------SGIDATWVDHATDFLS\n",
      "YLVKEKGFTCIKYYTIVNEPNGD--WSSTV---------G-S--------YPLWKNIIQQ\n",
      "FYRKMNEK-QLT--DKVRIMGPDVAIWSI-------------------------------\n",
      "------------AETSWVVNTRN-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------ELAE-EVKA-----FDIHAYPNND-------------DVHTTSF---------L\n",
      "QLLKAYKAASN------LDAPIIMGELGFKYS-----ATSSLGKANASRIKADPF---AA\n",
      "-DDSQMHVYDAF-------YGIDMADATIQVMLAGFGGVTYWDLDDAMYND---------\n",
      "-------------------------DGSSSSTKLKRWG----FWNILGSEKFH-------\n",
      "-------NPDDEKIRPWFYTTSLLCRYFP-SGSTIYDVTL-PKP----------------\n",
      "-------------------------------------------------VK-SGLRAIAG\n",
      "M---------RNG---KVTIAIVDSS-TNDYLFNLGMENG-A----LLQGIKTYKYQSQQ\n",
      "GA----HFIGTVDADG--------FASPVDAGETIDLSGGKLREINL-PAQSFMLLTNME\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UVR93289.1_Bacteroides_thetaiotaomicron_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MT--------------------------ID--------------------------\n",
      "----------------------------------------MKLIFVQLVI----------\n",
      "------------------------------------------------------------\n",
      "-----------------------------VC-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------FL-FA------------------\n",
      "-------------------CKS--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------E----NTVEITV----LKDTV--\n",
      "SHNYLGNGVEWDPY-DEAES-----------WGHSV-SEDDW-NKLFKRLDFMKPQYVRC\n",
      "MINSPYRYFISKDGSFD-----------------KTRNINSISRLLRYCTDRNI-TVIFG\n",
      "E-YNPPTFD-----------------------------------MKDSEKWVDMSVAYLK\n",
      "YLVCDLGFTCIKYFNIFNEPDGD--WASTN---------G-D--------YLLWKKMLFL\n",
      "FHKKISEYPMLA--KQVKLAAPDVVMDYH-------------------------------\n",
      "------NSNSEYDAEGWLMQTIA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DADD-IIGV-----YDLHAYPGQA-------------EVRSGSY---------S\n",
      "KLLASYKNHIP------SDKQIILGEAGYKYWR--T-ADSLLMAEYNRRLVNHPY---TK\n",
      "GTDCNMLCYDYF-------YGLDMPLLAMEVMNAGYSGLAMWMLDDAMHSN---------\n",
      "-------------------------GDSGKPEDIKIWG----MWNILGEEVFN-------\n",
      "-------SPKEEELRPSFYTWSLMCRYFP-SGADILKTEV-LDG----------------\n",
      "--------------------------------------------------N-NEIYAVAG\n",
      "M---------YKG---KLTVAIVNIG-KEDKKINLSLPK-------EMTSALLYVYEEEH\n",
      "L---------NKDENG--------FPLPVQTGMKLNS-----YSNTI-KSNSFIILTDLS\n",
      "DE----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QZU84679.1_Bacteroides_thetaiotaomicron_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MN------------------------------------------------------\n",
      "----------------------------------------KVIPLLAILL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------W-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------FC-TA------------------\n",
      "-------------------CGEKKST----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------------------LV---ISDQPV--\n",
      "SANFMGNGVEWSAY-PHGDSPEA-------EWGYLM-TDEKL-QKVCSRLDYMKPRIVRL\n",
      "MDVAGWRYFKGVDTKGNPI------VDF------ECAEVKMVCKLLDYCQKNGI-TVLIG\n",
      "D-YGVPGFW---------------GYKGKVD-------------RVDDPRYVDMTIRYLS\n",
      "YLIKERGYDCIKYYIITNEPNGT--WACTN---------G-D--------WEQWKRGVSM\n",
      "FAEGFKAA-GLP----LEMSAPDVVEMSD-------------------------------\n",
      "------NPASEYTGRQWVEQTMI-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------QLDS-IVGN-----YNIHCYADAY-------------FVRDGRF---------Q\n",
      "KHHKEVADILK-----TTGKPVIFGEIGVLYKT------GELGEEYKKLLPQKPF---AS\n",
      "-EDSQLHVYDYV-------YGIDAADALIQSMKAGFQGASAWMLDDAMHTI---------\n",
      "-------------------------GDLGDKNQLKVWG----FWNSLGTELLN-------\n",
      "-------DEKEEEIRPWFFTWSLMCRYFL-PGMEIFNPEN-EE-----------------\n",
      "--------------------------------------------------LFPNLRVVAG\n",
      "R---------KGE---EATIALLNAG-DSTYTFCLKMNVG-S----SKQDFAVYSYTQTG\n",
      "Y---------KTDENS--------FPVAESVARAKDLLSGE-EEIKI-LPRSFKLYTNIK\n",
      "ID----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">CBK67267.1_Bacteroides_xylanisolvens_XB1A_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MMN------------------------------------------------------\n",
      "----------------------------------------LKTIIGTFVV----------\n",
      "------------------------------------------------------------\n",
      "-----------------------------GM-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------LL-VS------------------\n",
      "-------------------CTHS-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------D----NRLTVNV----FQEVV--\n",
      "TSGYIGNGVEWDPY-DEAES-----------WGASV-SDEDW-QKLFKRLDFMRMGYVRC\n",
      "MINSPFRYYDPQTGKYD-----------------KTRNIASLSRLLQYCTDHNI-VVMYG\n",
      "E-YNPPTWA-----------------------------------MKDEQCWVDMSVDYLN\n",
      "YLVNDLGFSCIKYFVIFNEPDGN--WASTD---------G-D--------YDLWKSMLLR\n",
      "FADKMKEYPGLD--GKVKFAGPDAVVDYK-------------------------------\n",
      "------NPSSPFDAAGWVKQAAT-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLDS-HIGI-----YDIHAYPGQH-------------EVRSGQY---------A\n",
      "EILARHKEFIP------AGKKIVLGEAGYKYWR--E-ADSLLMKEYNRRVEGHPF---TK\n",
      "GTDSNMLVYDYF-------YGLDMPLLCMEVMNGGYSGIAAWMLDDAMHSS---------\n",
      "-------------------------GDSGKTEDIKLWG----MWNILGEEVFD-------\n",
      "-------DPSQEEIRPWYYTWSLMCRYFP-TGSNILKTTL-DR-----------------\n",
      "--------------------------------------------------T-KGVYAAAG\n",
      "E---------YQG---KYVFAAVNIG-DEDRSLDISLPA-------ALENVSLYVYEEGN\n",
      "R---------QTNNEG--------HPVPVQTGLTVDGT----YQTIL-KAQSFILLTNID\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QEG33916.1_Bythopirellula_goksoeyrii_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MR----------SNY-----------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------L-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------SS------------------\n",
      "------------------------------------------------------------\n",
      "---------ELGT-----------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------PR--------\n",
      "------------------------------------QL----PIIEVRV---DLSRAV--\n",
      "SRDFLGVGVQCDAY-PW----------------WDI-NELEW-DRIFKRLSYMRSPLFRT\n",
      "MQSAFYYW-HDIDGSGKPT------YRF------DSSYVNKLVKLLDWCEANGT-QVILG\n",
      "E-WGAPTSV----------------------T--------GISLANDDPLWTRIVVEFLM\n",
      "ELFRRRSYQCVRYFNLINEPHGS--WSSTA---------G-C--------FDEWRSAILN\n",
      "LHQDLQRS-GLH--DRVAIAAPDA------------------------------------\n",
      "-------------NSEWLRKTLTDS-----------------------------------\n",
      "------------------------------------------------------------\n",
      "------ELRE-VTAI-----YDEHWYVTRD-------------EINAGAV---------E\n",
      "QRCREQCRCISQCD---PGKPYILGELGIVDGK-------------------------TE\n",
      "-DDRQPNVFGFS-------YGVEMADAAVQLMRGGSHGFIAWYLDDAMHFFGDGEIVRSD\n",
      "------------------DE----PLPKDAYERRKVWG----MWNSLGNQMG--------\n",
      "-------DPSDAQLRPWFFTWSLLSRYFP-AGCEIVNVEL-DQ-----------------\n",
      "--------------------------------------------------D-APVIIAAA\n",
      "R-------ISQEGT-NHISLAIVNRE-DAPRTVRVHIPEM-Q----VLTTLARFDYFDLD\n",
      "SDDRPDSWPTSIDNQGC-----DVFPSPSLFLSEVDFQSGL--KIAL-DGRGVVILTSLE\n",
      "TAETM-------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------PPLY-------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------RSP------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ABP68096.1_Caldicellulosiruptor_saccharolyticus_DSM_8903_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------RWMKFFKSLS----GGI---------------------------\n",
      "----------------------------------------LILTLVFVGT----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------FF---------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------AIDFSKVKA----ADGTAVI---NFNKVY--\n",
      "WGDFLGVGIQWDPQ------DG---------SLPEI-DSTMW-DKVIQRVDFMNAKFARV\n",
      "MINVEDYF-NGST------------YNW------NSVVMQRLYKILDYCQSRGV-TVMLG\n",
      "N-WWKPSWA-----------------S-----------------SFTDSRFLTAICDLLN\n",
      "YLRNSKGYTCIRYYNFLNEPNGE--WMYGEN-------PP-DLE----TRWNNWKDGIIA\n",
      "LHNMLSSR-GYT--NWVQLVGPDTAY----------------------------------\n",
      "-------------QDDWVDRALN-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NLGS-QMGA-----YEFHIYKDYDS------------QVYNGEI---------E\n",
      "ATVGAKRNLIN--SSTQSNKHLWLGELGMKEGK-------------------------DP\n",
      "IYDCQPRVTTFE-------YAVVMSDGIAQVIRAGGSGVIPWCLDDAMHLA---------\n",
      "-------------------------SSDG---TLKKWG----MWNSLGGKTVG-------\n",
      "---TKTYPISDQNLRPWFYPVSLFSKFFV-QGSQVVEVSG-PS-----------------\n",
      "--------------------------------------------------I-PGVRVAAV\n",
      "K--------KQNGTNWDVSIVVVNNN-DSAKSILITAPGV-T----NTAIFKQYNFFASD\n",
      "Q---------PKDNDG--------FPLPKMDRVN-NLSNGI--LVDL-PSRGVVFLTTLN\n",
      "GGTPVS---VSSNLALNKPAYAS-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------STENSNY------------------------------------\n",
      "------------------------------------------------PPNYAFDGNL--\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------NTR-----WSSAWS-------------------\n",
      "------DPQWIYVDLGSVQTIS--------RVKLVWEAAYAKQF----------------\n",
      "------------QIQVSTDNVNWTTVYSNY-----------------NGTGGTNDITFTP\n",
      "VNARYV-----------K------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------M--YAW-----------------------------------------QRATQYG\n",
      "YSL---------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------WEFEVYQ-----------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">BDI31947.1_Capsulimonas_corticalis_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------KSLVS---------------------------------------\n",
      "--------------------------------------PPSIAALAWTLA----------\n",
      "------------------------------------------------------------\n",
      "------------------------------L-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------------------GPIWA------\n",
      "-------------------------------------A----SASDVTV---RLGKTV--\n",
      "TSPFMGLGVQWDRF-YYTP------------------TPAAW-NMIVRRMDYCRPGYLRV\n",
      "MVGTGDYC-VGFDAQGKPK------YIWTEGTAAQKADFKNLTDILDYAQSRGV-PVILG\n",
      "E-WSPPKK-------------------ELMA-------------EETDPRWPQVMADFVS\n",
      "YLRDKRGYSTITFFNCINEPNGD--WSGNK-----------D--------YATWLSVVRS\n",
      "LRREFDAR-GLN--ASVRIIGPDTTGNTQW------------------------------\n",
      "-----------LEPFTWIDRATK-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DAPD-TFGA-----WDLHWYALDS-------------EVLDGSM---------E\n",
      "KLLAEKREVIAKNDPDGLSKPRFLGESGLITGR-------------------------VN\n",
      "-GDQQPRVRAYE-------YGVMMADYVAQVARAGWQGALAWDMDDAMHLVSWDR-----\n",
      "------------------------RPDPPDALTMKLWG----FWNSQGSRMT--------\n",
      "-------PPEDESPRPWFYTWSLMSRLFP-RGSRIVETTS-PA-----------------\n",
      "--------------------------------------------------I-ARFRAVAA\n",
      "T-------IQRSGR-TDVSVMLVNND-AISRTMTVKVPDL-K----QSPTLTCYRYFETD\n",
      "R---------PEDDRR--------FPKAASLLKKVDLRKGC--TVML-PSRGVVFLTTMI\n",
      "DRQKN-------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------QSP------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ADV49313.1_Cellulophaga_algicola_DSM_14237_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MLK----------KQLFN---------------------------------------\n",
      "----------------------------------------YIILLIFLPL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AS------------------\n",
      "-------------------CQTVKKT----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------ELVKI---EADKII--\n",
      "SSEFIGNGIEWSAY-PHADADDA-------EWGLLM-TDKKW-ETVFKRLDYMKPKIVRV\n",
      "LDQANWRYLEGIDKDGSPI------LNF------ENQEMHALYKLLDYCEKNNI-KVILG\n",
      "E-WGQPYKVH--------DTH--LKMQNTFT-------------GATDPKWLNSIAQHVD\n",
      "YLVNTKGYTCIKYYNLVNEPNGY--WSSID---------G-N--------WNEWKLGVKK\n",
      "LDSAFVSK-KLK--TPVHVIGPDATPFNN-------------------------------\n",
      "-------EKSKYTGAEWAKESVL-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------QLND-VLAA-----YDVHDYPTKE-------------FVRSGDF---------E\n",
      "KHYTAMISFAD----SVARKPFILGEIGFEKYV----------ESNIKRYEADPF---AS\n",
      "-PDSQLSIYDYD-------YGVDMADVLVQSMNSGFDAVIAWGLDDAMHTN---------\n",
      "-------------------------GDTGEKNQLKKWG----MWNILGKELTG-------\n",
      "-------DVKEEDIRPWFYTWSILTRYFT-NDMKIVKTTG-LD-----------------\n",
      "--------------------------------------------------I-NKVRMVAG\n",
      "W--------SASN---DVTFSVVNNS-DKEATFYLETENL------KNKSFKKYSYSENN\n",
      "R---------PVDSNN--------FPKAVQN--NLSFTSGT-EQITI-PAKSVLLYTTYN\n",
      "Y-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ADV49311.1_Cellulophaga_algicola_DSM_14237_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--MTVK----------NI------------------------------------------\n",
      "-----------------------------------------FAAVLPMLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------I-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------A--AS------------------\n",
      "-------------------CDDEEPA----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------FTSLEK----NREVV-----ITEELV--\n",
      "STDFVGNGAQWGGY-EMTPTWL---------GTETL-SDADW-NTLFNRIDFMRPPFLRI\n",
      "VTNPAWSY--DNNGTYDE-----------------TTKTVSLFKMLDYAKDRNI-EITFG\n",
      "E-WGHSST-------------------DDI--------------STIDMGWIQNSVKFLN\n",
      "HLVNEKGYTNIKTINIINEPNGD--WSSTK---------G-D--------YNIWKNVQLA\n",
      "YLEEIKKY-SLA---DLKVMGPDIAVFNT-------------------------------\n",
      "-----------ASQTDWFTKTEA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLGD-NVGL-----YDIHVYPQQQ-------------LIRSGEF---------A\n",
      "QMLRAYKKETP------ADKRIVLGEIGFKY---TE-VDAQLKQENEEAIANDPY---AG\n",
      "-EDSNMMIYKAF-------YGIDMADALIQAMREGYSGSLVWNMDDAMYNS---------\n",
      "-------------------P----DNGDYQSDKLKRWG----FWNILGEEHTG-------\n",
      "-------NAADEAIRPYFYPVSLLTRFFP-AGSDIYKVNL-PN-----------------\n",
      "--------------------------------------------------K-KGLRAVVG\n",
      "T---------YNG---KQTIAIVNSH-YTTYELELKSDFL------GAITANKYSYKSKA\n",
      "DG----SFTGTVDADG--------FAVPSENNMNLNFAEGV--KMTL-EGESFILFTNME\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">APU67655.1_Christiangramia_flava_JLT2011_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MP----------DRLKA---------------------------------------\n",
      "----------------------------------------IFFVGTFLLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------FG------------------\n",
      "-------------------CDQKKDS----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------E----TFDSLTL---HPERIISP\n",
      "SDDFIGGGVEWSAY-PHADSDKA-------EWGLLM-TDQKW-QEVFKRLDFMQPKIVRV\n",
      "LDQANWRYLEGINDNGNPI------VNF------DNQEMQALYKLLDYCEKNKI-KVILG\n",
      "E-WGQPYKVH--------DPE--LQLQNAFS-------------GASDSKWISIIVEHID\n",
      "HLVNKKGYTCIRYFNLVNEPNGY--WSSVD---------G-N--------WKEWKSAVTK\n",
      "LDSAFKKN-GI---NQVDVMGPDSTPYNN-------------------------------\n",
      "-------EKSDYQGMEWPKQAVL-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------QLND-VLGA-----YDVHDYPTVE-------------KVRSGKF---------Q\n",
      "EEYTKLISFAD----SVAHKQFVLGEVGFEKYV----------EPNITRYEEDPH---AS\n",
      "-PDSQMRVYDYD-------YGVDMADVMAQSLNAGFDGVIAWGLDDAMHTN---------\n",
      "-------------------------GDSGDTTQLKRWG----MWNILGEELTG-------\n",
      "-------DKSDEAIRPWFYTWSLMTKYFK-GDLNILHVQG-SL-----------------\n",
      "--------------------------------------------------P-EGVRAVAG\n",
      "K--------STKG---DCTLTLVNNS-GQPVSLSIDGKSF-SM---NDQRFQKYLYSEKE\n",
      "R---------PVDSEG--------FPVALKR--NIRMP----EALTI-PAKSVMLFTTYT\n",
      "N-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">APU67659.1_Christiangramia_flava_JLT2011_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MQ----------REHNS---------------------------------------\n",
      "--------------------------------------LPGLIILTFLIL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------A-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------FYGNS------------------\n",
      "-------------------CIA--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------Q----TRATVSI---NGNSLM--\n",
      "PNKYLGNGVQWDPY-QLDYGA----------VTLEI-DDQDW-KKLYDRLDFMRPQVIRV\n",
      "MINTTSSL---NNGKLDP-----------------QKNLSNLKPILDYCQSRKV-SVTFG\n",
      "D-WGGGMV-------------------DSSA-------------NLINKENLEFAAEYLD\n",
      "FLVNEQGYSCIKYYNLINEPNGF--WSAAD---------G-N--------YELWRDAAVY\n",
      "FQQSLERL-KLV--NKVQIMAPDIAIWTA-------------------------------\n",
      "------------DKTDWVSRSAK-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLKG-AIGL-----FDIHTYPSKI-------------TVNSGEY---------E\n",
      "KIIKEYRKAAP------ANVPMIMGEIGFKFVE--D-EDSIYQKENLRRAASKPY---AS\n",
      "VEDSQMYVYDHS-------YGIDMADALFQTINAGYSGCVVWMLDDAMHSK---------\n",
      "----------------------------ESPEKLKVWG----FWNILGEEYF--------\n",
      "-------GESEESVRPWFYAWSLLTKYMP-SGSRVLKMGN-TG-----------------\n",
      "--------------------------------------------------D-KEIKAVAL\n",
      "R---------YGN---AYTIALLNIA-DEDKDVQLSTKNI-Q----TSGKFQKFTYAKGN\n",
      "L---------QTSGDH--------ELLADGY-LKINESGIE--HMSL-KPGSLTVLTTLK\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">WLC65246.1_Clostridium_tagluense_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MEFKV--FKG-KSKLGETGIII----------------------------------\n",
      "----------------------------------------LIFTIMWLLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------L-----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------PLQV------\n",
      "-------------------------------------Q----ATSVISV---NNNKVI--\n",
      "QEKFLGVNAVYHGF-AYMPEEE----------SKGM-NDNYR-KIEFNRVENMNLHIART\n",
      "WYRPDFACGDDLMNN----------FDW------NSVKMKAFYSWCQKMKDRNV-DIAIN\n",
      "PWWSSGTN-----------ADVWWGGQSYQW-------------KVYLPRFSEWLSESIN\n",
      "QLVNVRGFTNIKYVMLLTEGSQG--YLDTEKP------SG------FLSLWDWHRNIIKE\n",
      "VHIKLVED-NRR--NLVKIVGPNNG-----------------------------------\n",
      "------------NGGEHFEEALL-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GCSN-EIDILSGHNYDLHDYNAWY-------------DEAKKMV----------\n",
      "-------DYAK-----LINKPMWFDEYGETDKN----------------LRSSPL-----\n",
      "-------------------YGNYIAQAVAGFMNAGCATSMLWLLFDQGYPY---------\n",
      "-------------------PLDKISNKDSFYNGIHEWGT--TYW----------------\n",
      "-------LPESMEPRPSFYAFSMISKLMGGTGTKVYETT--CS-----------------\n",
      "----------------------------------------------------SDVYISAS\n",
      "K--------QLDE---NWSFLIVNGS-NLEKDISVNLSID------INKKLYRYLYDPTL\n",
      "M---------QTNVKS--------KIISHDKVFNKVLN-NF--TDTI-PPKAVVIYSSIN\n",
      "DSHKG--------------------LSVLNNI----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------NDTFKFVLSCI----------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------IVL------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------SILLIA\n",
      "VVVSK----------------------------IIP------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------------------------RR-------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QTH43817.1_Cohnella_sp_LGH_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MT---------RLKLSF---------------------------------------\n",
      "----------------------------------------VLGLIVALTL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------GS------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------LPYYESANKVY--ASSTVDIELRNNSPAY--\n",
      "GGTTLGMGGTIMPF-GYHASWQ----------VKDF-NDDDL-AAIMTQFKKTGTTVARL\n",
      "WLDGSWW--EPENDNNDPDVMLDSGFTW------DSIEMRSLYKYLEAFKAMGV-DVFVD\n",
      "VMVDDPRV-----------MYPWLIAENKVN---------TGPNVGQIPEYAEHIAAMVK\n",
      "HLVVTKGFTNVKYVSFSGEPNNF--FLAPP---------GVSK-------LDNYKASMTA\n",
      "VHDRLQLE-GLL--AYVKLIGPEIGYSDH-------------------------------\n",
      "------------DTAAWLDDLSL-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NIPS-SLDA-----YTIHSGQTKA-------------EATDGSY---------V\n",
      "ALLQSFIDIVKSNDPDGADKPIMITDYTPTGTI---------------------------\n",
      "--------RRPE-------DGLNAVALIANGLRTGVSEFGRWSFADDIWTW---------\n",
      "-------------------P----PGSNQTSTSFGDYG-----FGMIGS-----------\n",
      "-------KQENFTPRPNYKATALAYKFVP-RGSTTYEAVT-SD-----------------\n",
      "----------------------------------------------------EAVIPAMI\n",
      "R--------TAEG---KHTIIAVNWS-DNDANVSFALDSA------LNTTFKKYRFSSAS\n",
      "LD--------LVDKFG---------EIPSSFGTKTVNGVSF--TDTV-PANTIYFYTDIP\n",
      "DDSAP--------------------GQVTGLSAASA------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-DFKKATLSWTAGTEADLSYYRIYRGNTSGFAPSRDNKVGEIWIPAGDAPAFNDRNVEQ-\n",
      "---GQTYYYKVSAVDTSENEGGYSSEASV-TIGSETYSNTLSMTDSTDYDYYEIDSDYEN\n",
      "GYKVRVYKNAGVIGYVQDKLGYNRQNLGLDIFSAPMVFKYDAN----------AYSDK--\n",
      "--IVNGGAENG--------TTAP----------SDWHSW---------------------\n",
      "---NNANGT--------------------------------FTWD-SSVKHSGSRSLK--\n",
      "--------------IHNSAQTANSTW-------------------------YQQTTN---\n",
      "-----F-----------------VPGKHYEASYWIKTDNLIGPNSAGRGAYLNIQ---FL\n",
      "DSSGNTIRATGGADAYSNVGTQDWTYFTSD------------------------------\n",
      "-----------------------------------VTVPLGTATIQIGANLYENSGTVWF\n",
      "DDIRFEEQPEVALAGQHGGYYAADSVTAQSISAT-----------HKQIVTVAGDETMVY\n",
      "DFYPDRIEMKVQGPNPGGYFVEDGGIVPRNVTTAYWSDGSANTLSDTYAGTLIEKTTISL\n",
      "AFYQPPSPQTIRYEFGSPKPLTVKNGARFRGYYPRFQIDSNEAFTLKF-PKKI-------\n",
      "----DNPNGGAEN----------GSAAPADWTMWNQSGHGALTWDAGTFHWGGKSLKISH\n",
      "ASTDNS-------AWYAQVEVSAP----------TPSIQLSAWI-----------KTSAI\n",
      "SGSQGAFIS-----------------------------------------VEAKD-----\n",
      "--------AAMNVL------------ATYRTPFVTG-------------------TTDWK\n",
      "RYALSLNPPAGTAYLFVEGN----------------------------------------\n",
      "---LFAATGTAWFD-DFELNSADTGIANPGTEVGSGSPADWW--------SWTSSGTPFE\n",
      "WDGTTYYSG----------------KKSLKITNTANQTSTWYTKRSNLQMSKEYEFGGWV\n",
      "KTSGVSPGSMGAQLQAIALDSN--------------------------------------\n",
      "--------------------------------------------------GKWLQANIA-\n",
      "-------PNVLHGTNDWTYVS------GKI-----------TLPPMASSLQLEAQLWGVN\n",
      "G--------------TAWFDDLFIRLVDKS------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QHS51394.1_Edaphobacter_sp_12200R103_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------NVLCF---------------------------------------\n",
      "----------------------------------------SLLLIAASLA----------\n",
      "------------------------------------------------------------\n",
      "------------------------------T-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------P---------\n",
      "-----------------------------AQPSEHPKN----VPQEMKV---DLSAQP--\n",
      "LGKFLGLGVQFDPYV------------------NQV-DAHRW-AEMMDHLAYMKPGFLRV\n",
      "MSGATDYC-SGFDAKGEPI------YRW--DTDPTARQFQAILTVLDFAQAHHI-EVYLG\n",
      "E-WSPPGS-------------------LGIH-------------SPDDPRWQRIISDFVQ\n",
      "YLVRDRHYTVIHHYIFMNEPNGDWMWHGRK---------P-D--------FTSWSTGVRN\n",
      "LRHQLDAR-GL---DDVILTGPDNS-----------------------------------\n",
      "------------GGRQWFDRTVT-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------EMHD-VFGT-----WEQHIYAKDQ-------------EVESGTL---------E\n",
      "RELISDRETILKHDPDGASKPRFIAESGLVTGK-------------------------IQ\n",
      "AVDQQPRVHDFD-------YGARMADYIVQVARAGWGGADAWDLDDAMHRG---------\n",
      "-------------------P----GG------GWKIWG----FFDS------N-------\n",
      "-------SDAGMKPRPWYYAWTILSRSMP-NGAEILPVTG-SS-----------------\n",
      "--------------------------------------------------E-TPVRATIA\n",
      "K-------WNSSGK-TQWTLVLVNHT-DASASVNLKLPKQ--------DELHVFRYFATE\n",
      "Q-----------NVDG--------ALEPKESELEENPQRSQ--TVSL-PSRGVVVLTTAT\n",
      "AGTG-S---AARQAVLNYLKDIS-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-GSK------TAV----GVQNKDV------------------------------------\n",
      "-------------------------------------------------ANLTRDTDR--\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------------------IAALTGKQP----\n",
      "-----------------SFWGAD--------------------------FSYGPRA----\n",
      "-----L--DKNREAMI-----------------------KEAIAQYKAGALV--------\n",
      "---GLMYHA---------------------------------------------------\n",
      "------------------------------------CAPILPDET-----------CDWN\n",
      "S---------------------------------------------------VGGTKPVH\n",
      "--LTDAEW---------SQLTTPGTVLYKT-----WIARLNK------------------\n",
      "-------------------------------LSVYFQQLKDADVAVLFRPLHEMNQCVFW\n",
      "WGCHLGPNGSAKLYQITHD-----------------------------------------\n",
      "-------------------------------------------------------YLVNT\n",
      "KGFD--------------------------------------------------------\n",
      "-----------NI-----------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------V--WVWNVQDFNTLDTDVNSYNPGSSYFDIATLDVY---------------NTG\n",
      "YT---------Q------------------NNYNAMV-----------------------\n",
      "-------GIAEGKPIAVA--------E---------------------------------\n",
      "--------------------------------------------------CQYVPTPAL-\n",
      "LARQNRWVYVMLWSDFISNPRNQIA-----------------LPALYHSPNVVTL-----\n",
      "-------------------DQM--------------------------------------\n",
      "------------PGW---------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------GTR--------------------------------------------\n",
      "------------\n",
      ">QWG05959.1_Flammeovirga_kamogawensis_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MVK----------SKFRT---------------------------------------\n",
      "----------------------------------------NPITVFICTL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------I-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------LCLSS------------------\n",
      "-------------------CSESE------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------L----PTTILTF---DNSEVI--\n",
      "NTNFLGLGVQWSTY-PHADANQD-------KWGNIMMDKKRW-EFLYKRLDYMKPQFIRI\n",
      "LDHAEQRYFRGIINQSTPN------INF------DRMEMHALYQVLDYCQENSI-TVIMG\n",
      "E-WNPPWQ-------------------LR---------------NNQYSIWVKMIGKYMH\n",
      "HLIVKKKYTCIKFYSLINKPNTI--TANTK---------G-D--------YNQYHTAISL\n",
      "VKKEFEKV-NIN--QQLSLLGPSIDPLLH-------------------------------\n",
      "------YSKNGLTSLDWLQKSLSDT-----------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------VYDA-----IDIQVYPSEN-------------NILSNSL---------S\n",
      "TVFNLDKKIIK-----QKNKPLIISEFGIRPQK-----NSEESYYNDSLIALDEH---AS\n",
      "-RLSQMKVYQND-------YAIYTSDAVIQLLQAKADGIIAWHLDDAMFTE---------\n",
      "-------------------------ANDGNKNQLIKYG----MWNSLSDTLFN-------\n",
      "-------NPSDMKLRPWYFSWSWISKNLP-RGSQVIKLTN-NN-----------------\n",
      "--------------------------------------------------H-QKIKGVGT\n",
      "I---------NNN---DYVILLSNLT-DRDEYVEINFTDN-I----VDKTFYSFSIGQDD\n",
      "T---------ILKFNS--------MILPKNKHHRIGINHPL--FVKL-SAREMLILTTKK\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ANQ50808.1_Flammeovirga_sp_MY04_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--MTLK------------------------------------------------------\n",
      "---------------------------------------RLLLSLLSISI----------\n",
      "------------------------------------------------------------\n",
      "------------------------------I-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------FCLST------------------\n",
      "-------------------CKKG-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------K----PTSKLTF---NKKNKI--\n",
      "NHDFKGFGIQWSTY-QHADAPGD-------SWGFLMKDSSRW-NLMFERLQHMKPSIIRI\n",
      "IDNAEDRYFRGLDPKGKPI------VSY------NRHEMHALYKILDFCQQNSI-QVILG\n",
      "E-WNPPWQMQ----------------------------------NGNEHLWTEMIADYMY\n",
      "HLVRVKRYSCIKYFTLVNAPNTY--KAKNQ---------G-D--------YDVWKNWVIG\n",
      "LENEFSKY-HLN--KYVTIMGPSSDPTWD-------------------------------\n",
      "------MPLKTLKGKDWLAQSNE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLKE-TIGA-----FDVHAFLDEE-------------AVIDGRT---------E\n",
      "DFLHLNPNEIQ-----NLHGPLFISELGIKPMG--D-------------VLKDGR---SS\n",
      "-RLSQPKVFDEE-------YAELTTLACMDLLQVGVDGIVAWYLDDAMYTE---------\n",
      "-------------------------ANDGNTEQIMRWG----MWNSLGDTLYH-------\n",
      "-------DPSELKIRPWYYTWSLLSSNIQ-KGSTIVQINN-NN-----------------\n",
      "--------------------------------------------------H-QNINAVGV\n",
      "V--------NARN---EYVILLSNST-SEEQIIEIDFTEG-L----DNEEFYCVRMNHKK\n",
      "K----------SDGNS--------IILPKNDDIELVDNRSL--LVRL-SNKEMKLITSGE\n",
      "F-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------LYSFK-----------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QWG01382.1_Flammeovirga_yaeyamensis_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------LLTKV---------------------------------------\n",
      "----------------------------------------FLSGIITTTF----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------LS------------------\n",
      "-------------------CQEEKQH----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------------QYFAKI---EADKYI--\n",
      "SKNFIGNGIQWAAY-PHADGPNS-------EWGDLI-TPAKW-DTIYERLDYMQPQTMRV\n",
      "LDQANWRYYKGRDQKGQPI------FDI------DNPEMKTLYKVLDYCQTRNV-DVVFG\n",
      "E-WGTPFHVH--------DLHIKNAKENRFE-------------NAYDPQWISLIGQYVE\n",
      "HLIVEKGYTCIKFYNHINEPNGD--WASTN---------G-D--------YEEWKKGVID\n",
      "LQKEFEKR-GLD--KYLSITGPGTVPQYT-------------------------------\n",
      "------KKGFDYTGEEWVTKTIA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DIDT-IVGA-----YEIHTYLGTD-------------NTRNGKA---------A\n",
      "ESMHMLMDMPE---VNKTGKRFFVGEIGIKDE-----WDSKYQELNVEAAKKDGY---AS\n",
      "IYDSQMAVYTYQ-------YGVDMADAVIQLMNAGAQGMIAWDLDDAMHTK---------\n",
      "-------------------------DDLGKVDQLKRWG----CWNILGTELID-------\n",
      "-------RPEDENIRPWFYPWSWLCKYFP-KGTDIHTMDT-QL-----------------\n",
      "--------------------------------------------------P-EGIRMTAG\n",
      "K---------IND---DYSILMVNNS-DTLQNIAVSAPIQ------KSVKLKQLQYTADD\n",
      "Y---------KLNTE---------MGRPALNNTDLDLRKGG--VVPL-PARSVTILSSL-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UII20690.1_Fulvivirga_ligni_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------RLL-----------------------------------------\n",
      "----------------------------------------IYPLALAMGL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA------------------\n",
      "-------------------CQSTNET----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------SS----QKDLVSI---YPDQVI--\n",
      "SDEFIGNGVEWSAY-PHADADDA-------EWGLLM-TDAKW-QKVFDRLDFMQPRIARV\n",
      "MDQANWRYLEGFDDKGEPI------LNF------ESQEMKSLYKLLDYCQEHNV-TVILG\n",
      "E-WGQPYKVH--------DPQ--LHMEDKFT-------------GANDPNWIKIITANLK\n",
      "NLIQNKQYTCIKYYNLVNEPNGY--WASTD---------G-D--------WEQWKEGITM\n",
      "LNTSIKEA-GLS--DHIAVIGPDATPYNN-------------------------------\n",
      "-------DKSKYTGYNWAIEAVR-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------QLGN-VLGA-----YDVHDYPQKD-------------FVRSGEF---------G\n",
      "QHYKEMVSFAD----SVNEKPFIFGEIGFEKYV----------EGNIKRYEADSF---AS\n",
      "-PDSQLGIYDYD-------YGVDMADAVIQAMNAGFDATLAWGLDDAMHTN---------\n",
      "-------------------------GDSGDKHQLKKWG----MWNILGTELTG-------\n",
      "-------DSTEENIRPWFYTWSLMCRYFP-GEMNIVKSDS-VP-----------------\n",
      "--------------------------------------------------A-KNVRMTAG\n",
      "V---------FGK---YMSMAIVNNS-DSTANFTVHPGNL-G----EGATFKKFLYTEKQ\n",
      "R---------HKDENG--------FPKPVET--DLKGSTAL--EVEV-PARSFVLYTSYN\n",
      "Y-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UII20686.1_Fulvivirga_ligni_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK------------------------------------------------------\n",
      "----------------------------------------YLLTLTFLSL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------I-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------C--WA------------------\n",
      "-------------------CSHES------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------P----TDATITI---NSATVI--\n",
      "NDSYIGNGAQWDPY-QLNYGD----------TTLQI-SSQDW-DKLYSRLDFMKPQLMRV\n",
      "MTNTRNSV---RDGKLQP-----------------ELHFSNLKPILDYCQTHNI-QVLFG\n",
      "D-WGGDMV-------------------HSKE-------------NKIDSANLHFAAEYLD\n",
      "FLINQKGYSCIKYYNMINEPNGF--WSATD---------G-N--------YQLWANAIRF\n",
      "LHKGIVDL-GLD--NKVALVGPDAAIWSG-------------------------------\n",
      "------------EEAWWADSCAT-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------HLSK-EVGL-----FDIHTYPSKV-------------TVNSGEY---------T\n",
      "DIIKAYEEKVP------EGKKIVMGEIGFKFVE--P-ADSAFNKENISRAEAKKY---AS\n",
      "TDDSQMFVYDYS-------YGTDMADALFQTVNAGYSGSIVWMLDDAMHSK---------\n",
      "----------------------------EAPNKLKVWG----FWNIFGDEYF--------\n",
      "-------GSEEENVRPWYYAWSLLTKYMP-QGSQIFEVKS-TG-----------------\n",
      "--------------------------------------------------D-PSIKAIAL\n",
      "N---------KNG---QYMLAVVNVS-QESHSVKIQSTDL-K----SLQGANKYIYSKNT\n",
      "L---------KKEGDH--------GLLPNETDLNINLSEGV--SLDM-PAESLIVISTFK\n",
      "NE----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">WPO86937.1_Herbiconiux_sp_KACC_21604_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MRRD-------VRRAALAAIAV----------------------------------\n",
      "----------------------------------------GGLLVGALAG----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------GV------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------QAATAAPGGD----QPVDVVV---HTGDLV--\n",
      "QDDYLGVGVNVIPW-SLMGDTA----------TLGY-DEADW-QVDVERILTLRPKVARF\n",
      "WFQIDWM--ELQKGQ----------YDF------DSPEMKAVYRYLDAFKQAGT-EIELN\n",
      "FGWKVGER-----------IHDWFTIPGVE----DP----YISAPADLPAYGRSASALLQ\n",
      "NLWG-RGYENVKYLTYYNEPNGS--WDFEA--------PG-DE-------KAYYAQMAQA\n",
      "VSDQLVAD-GIR--DRIEIWGPEEV-----------------------------------\n",
      "------------SAPDWTAFMEQ-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NAPD-AFDG-----YSFHLYGEAY-------------SSLDDII----------\n",
      "---AARTSVA-------NGKPVSMTEFGWASPE-------------------------AS\n",
      "VWE-----------------T-GYANYVIDSANKGVHTNLVWQLNGVMTDD---------\n",
      "-------------------P----RGD-----TNGDYN----LWDS--------------\n",
      "-------VILGLEPSPAFYEAGPLLRYIP-AHSSVYATEV-SS-----------------\n",
      "----------------------------------------------------PDARATAF\n",
      "R--------DGDG---EWTVLVETKD-GAAKDVTVRFDGD-KSREASKGSYTRIAMTDAD\n",
      "A---------QPEQNA---------LLPASSGSLKVKKGAF-TDREVTDAHTQLVYTQAP\n",
      "AQTQVALDDPQIEVVGGSTTKLG--ASVIDGH----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----ANVTWSVI----GSDDGTV-SPSGKYTAPQVTTERTVAITATSRSDGSSYAVQQV\n",
      "LVTPAHRDGVTDAPVFSLPAGQYDSLEGV-TITSPTEGASI---------HYTTDGSQPT\n",
      "AES--------------------------PEYTGQIVLPALKTTYLRAI----AIAPG--\n",
      "--QEASGTTSRLY-KVLDVQNAP-----------DGYTFCAYD-----------------\n",
      "-------GQ--------------------------------------QCAFDGEQS----\n",
      "-----------------VVYGSDGL------------------------FAYGTFAGGVE\n",
      "CTAEAFGSDPNPGGDNRCFVNPVIPDEVPAVTVFNAGFEKPATSSAANGPMVN-------\n",
      "---GWTFSVRSGVQSNTS-------PFVPA------------------------------\n",
      "-----------------------------------FPAPEGER-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAYLKTDSGLASS-------------------------------\n",
      "------IEQTVRFPAG--------------SYAITFQAANRSGF----------------\n",
      "--------GGQQEFDVTVDGTVVAHVVPSMTGEYALYTS-----DTFTVEAGEHTIAFVA\n",
      "TTTDG-----DNTAFVDQVAVVSA-----------P------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">WPO86936.1_Herbiconiux_sp_KACC_21604_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MT-----RTF-LSRGLAAAT------------------------------------\n",
      "----------------------------------------AVLLSSAALV----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------AVTAAPAHAA----DAVTVSI---DPDTVV--\n",
      "QSDFLGIGVNVIPG-SLMEGTT----------ELGY-TDADW-AIDSARIEKLRPKVARI\n",
      "WFQTDWM--EPSKGS----------YTF------TSDRMLAFYRYLDAFQAAGT-DVELN\n",
      "FGWKVGSS-----------IQSWFSIPGV-----DP----WTSAPDDIPAFADAASALLD\n",
      "ELITQRGYDNVKYLTYYNEPNGS--WDFEA--------PG-DQ-------KAYYLAMAQA\n",
      "VSDQLETD-GLR--DDVEVWGPEES-----------------------------------\n",
      "------------GAPDWTSYMAA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NGGD-AFDQ-----YSFHTYGDSY-------------SSVAGSI----------\n",
      "---AARTSVA-------GGKPVNMSEFGWSSDT-------------------------AS\n",
      "GWD-----------------S-GYANYVIAGANQGLHSLLVWQLNGVWTAD---------\n",
      "-------------------P----DGD-----TNGTYN----MWDS--------------\n",
      "-------VLLGLEPRNTFAAAGLLTRYVP-AHSDVVQATS-SS-----------------\n",
      "----------------------------------------------------GDVRVAAF\n",
      "R--------DADG---EYTVLVESKA-GADKNLTVDFGSL-D----LGSDVHRVEYTPDL\n",
      "V----------PDENA---------LLPASSASIPATT-SF-SDT-LGGDYTVAVYTTAD\n",
      "PAVQVALDDVDPTVASGSTLQLG--ASVVDGA----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----AGVTWSVE----GTGNGSV-SSSGVYTPPAVTTERKVAVIATSTADPSATAVARV\n",
      "LVTPASDPAVVSPPSFSLESGVYDGARML-TLSTATAGAEI---------RYTTDGTTPT\n",
      "ASS--------------------------TLYEHPIVLAESTTRLYQAA----AFAPG--\n",
      "--LTASGSASRLY-KVGAVSDGP-----------DGYTLCADE-----------------\n",
      "-------NG--------------------------------------TCFFSGQQS----\n",
      "-----------------VAFGGDGL------------------------FSYQTRTGDTA\n",
      "CTTAEF-GDPNPGVEQHCYVSPTIPAEYPIVTITNAGFEKPGGTKSKTGPFVN-------\n",
      "---GWTFNNRSGIQNAQG-------PLGPG------------------------------\n",
      "------------------------------------TPPEGAQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------VAYLKTDAGVQGE-------------------------------\n",
      "------ISQELTFPAG--------------TFQLAFELSGRSGY----------------\n",
      "---------PAQTFDVLYDSTVIGSFTVSSTTSYTPVRS-----AIFASAGGKHTVTFRA\n",
      "TAPSG-----DRTAFLDDVRVE------------LPAA------------PAVP--ALAN\n",
      "AGFESPATT---------------------------------------------------\n",
      "--------------------------NVKSAPFT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------DGWA------FVGKAGIQHNGSAFG-ATT--------------APEGTQTA\n",
      "LLQS---------------------KDGSHGSFTQSVDFVPGDYRLTFQASKR-------\n",
      "-----AGY-ATPQPIEVLVDGTVV------------------------------------\n",
      "--------------------------------------------------ATATPSAS--\n",
      "-------SWTGYTTPVFTVGR------G------------------AHSIAFRGS-----\n",
      "---------APTGDATAFVDAVGLEAVPAA-------GLEAATTAAAWSLCVGTEAYVAV\n",
      "YS-------INKAGRDVDMRLGA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------VGAEKEETGVADGTAAYGLFPS\n",
      "G------ASTLAA---------------------------------------GTAEVEA-\n",
      "-----------------SYLD-GTEHTSTQTPSYAA---------LDCSAE---------\n",
      "------------EG----------------------------------------------\n",
      "------------\n",
      ">WEV39865.1_Lactobacillus_sp_ESL0681_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK---------HKKIKLFTILS----------------------------------\n",
      "----------------------------------------VVTTLMAPIL----------\n",
      "--------------------------------APVTT-----------------------\n",
      "-----------------------------SV-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AAKS----------------\n",
      "-------------------ATNQKKTK---------------------------------\n",
      "--------NEL-----------TKYDRKWQTYNSNDSDVKLDYHDDEVIASFNKSNGKDY\n",
      "WDSQLFLPDIKLANGKYQLSFKVKATKPSSIYFDIEDSND--------YQTKYYPEKLLD\n",
      "LDTQYQTKTINFDLKDQSI-----------------LDDKKQIKLQFNLGPN--------\n",
      "-------ENTKSLAQQ-KLTFADFKLVK-KANASKVKK----QKASFTV---NGDNVL--\n",
      "VKDYKGFGVQWDPY-TA----------------RPV-TDQEW-TMITKRVDYLHPSFVRV\n",
      "MLYANTYC-KGLDKSGNPI------YDF------DSKANQALLRELRYLKQKKI-PVILG\n",
      "E-WEAPGR-------------------FNGA---------FSGINADNPKWAKIIVGFLN\n",
      "YLVNEQGFTNIKHFNYINEANSD--WSYCA-----------D--------YDKWHQGITY\n",
      "LYDELSKY-QLT--DKVTITGPDTVWD---------------------------------\n",
      "------------DQNSWLHNIANDH-----------------------------------\n",
      "------------------------------------------------------------\n",
      "------DFSQ-KLGL-----YDTHMYPSVE-------------EITDGKV---------E\n",
      "QQVAEQRSVV-------KGKDFYMTELGLVTGK-------------------------TN\n",
      "-GDSQSYIRDYR-------YGILMADAAAQVARGGFNGVSLWDLDDAMHDQD--------\n",
      "-------------------N----GFPSSDIRSLKQWG----FWNSVGGRLYN-------\n",
      "-------EPKEEQIRPHFYTWSLMTKLIP-PHSEILGETK-TGK----------------\n",
      "--------------------------------------------------S-AGFRILTA\n",
      "K---------KGK---DVTYVLIKDS-NKSGSLKLKSKNLSK----TKQKFYRYNYFKNQ\n",
      "R---------KVNTNG--------FPVATSK-KTIKLNHGK--TFNF-SGPGVIILSTKK\n",
      "VK----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QHO70380.1_Marisediminicola_antarctica_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------------MVAVLAVSL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA------------------\n",
      "-------------------VTDSADRS---------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------FADSLSGSS----AVSVVVA---NSTTGV--\n",
      "VKEGLGWNAE-----NVWQSENK------IDGGINW-GTTQW-DQYNNMVKFLNPQVVRL\n",
      "GVQVPYW--SPSYGT----------YTW------NSSWMQNLYQQLDAYKAAGV-TVMLS\n",
      "N-WWTSSNY----------PDNFWWSETSRNGTTDPDSFKRNDLPYDNAKFSEALVAGIK\n",
      "HLTVTKGYTNIKYLSAWNEPDWN--FVSANASYPASATSG----------SNTFWPLYTS\n",
      "IGNALTTA-GIR--SQVSIVGPETSWIERFGP----------------------------\n",
      "------------NIKTYVKTPAAGQ-------P---------------------------\n",
      "------------------------------------------------------------\n",
      "-----QQFGQ-VVDA-----IAVHDYDSFSDHDTRTYDNARDYFTATSTI--GRVA-DIK\n",
      "TSVNATYAAAG-----KPAPPMFVAECCNTAYGA------------------------AY\n",
      "INDASAVTDD----------GLFSAEMSARYLSSGVDGVMRWNLTTTSQGG---------\n",
      "--------------------------------LPYETGFVPITYDF--------P-----\n",
      "-------SQTFSAQGGSYYSAAILSRYLS-KGASVHSTTV-TGA----------------\n",
      "--GSP-----------------------------------------------ARVFATAL\n",
      "K--------RADG---NWTIYLVNND-YTDRQADLDLSAL-GIP--TSTPLYQYEWSSGN\n",
      "P-------------NG---------ILAKQALTYQGRT----FNLPL-APRSVSTFTTLG\n",
      "SDFTPQSMLTVNQATGGVTATSVA-APVANSGFETG------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----SSSGWTTTGS-VTVQNSPVWANAGSYVG---------------------------\n",
      "TLNSSVGAAELAQTLTGLSAGSYVLSAHIRTAGTNTATIGVKNFDGT--KNYSQDVTSSV\n",
      "YRSA-------------------------SVY----------------------F-----\n",
      "-TVPTGGGSATVYVKVPAGSSGTFVN-------LDDVRVVRIA-----------------\n",
      "------NLA--------------------------------------NGGFENASP----\n",
      "-----------------FYWTASGSA----------------------------------\n",
      "--------------------------------------SRQAVTSARSGGVVG-------\n",
      "-----TISTSTGA-----------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------GSFSQTVNGLAPG-------------------------------\n",
      "---RYSFSGFVRGSAGITSSIS-------V-----------SGY----------------\n",
      "--------GGA---------TVTASGTSSSWQRVSV---------PFTVTTANSTATVTY\n",
      "SAPAGS---AGSYSNGDDFEVKRN---------PSPQPNYTDLLAD---FSKMS-SHSAN\n",
      "LAFD-GANSEFLG----------YNSHR---------------------LVRSSN-----\n",
      "--------TAAYVA-------YTVPSGTTMKGFV--------------------------\n",
      "------------------------------------------------------------\n",
      "------VSSYFWP--GEAIANFQFATSPDGVTYTPIAPTQTA----------VPDPIGTN\n",
      "WTVVGYTN----------------------------------------------------\n",
      "-----STVPAGTKFLKITFANTTA------------------------------------\n",
      "--------------------------------------------------NYWNPQ----\n",
      "----------------------------------------------LSSVQI--------\n",
      "--------------------------------------------------------F---\n",
      "H-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">APF34734.1_Microbacterium_paludicola_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------RRIGAAVAAA----------------------------------\n",
      "----------------------------------------ATVIAGSVSV----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------GA------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------LGPVSPATADDTAPAEQRTVTV---ALDETV--\n",
      "QEDYLGIGVNVIPW-SLLEGTT----------RLGY-DDADW-EVDVERILTLQPKVARV\n",
      "WFQIDWM--ELEKGQ----------YDF------DSPEMRAFYRYLDAFEQAGT-EVLLN\n",
      "FGWKVGER-----------VHDWFLYPGVT----KP----YESAPGDLDAYGRSASALLD\n",
      "ELINARGYDNIDFLTFYNEPNGS--WDFEG--------PA-DQ-------KAYYAEMARK\n",
      "VHDQLIAD-GLR--DEVQIWGPEEV-----------------------------------\n",
      "------------NAPDWTQYMAE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NAGD-VFDQ-----YSFHLYGESY-------------EFLGNAI----------\n",
      "---DQRRSTI-------GDAPLNLSEMGWTNPG-------------------------TS\n",
      "VWE-----------------T-GYANYIIGSANNGIHSNLVWQLNGVMTHD---------\n",
      "-------------------P----AGD-----TNGSYN----LWDS--------------\n",
      "-------LVLGLEPTAAFYEAGLLMRYIP-EHSTVLGTET-SH-----------------\n",
      "----------------------------------------------------DDVRATAF\n",
      "R--------DRDG---ELTVLVETQS-GSPKDVRVEFTGG-D----VTESFTRLAYSDSI\n",
      "V---------EREKNA---------LLPASSGTLTPTSNAF-TDDAIGDENTFAIYTTSP\n",
      "AATQVAVDPVESTVAGGEQLDLD--ARVIDGS----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GDLTWSVV----GDDNGAV-DADGVFTAPDVTTERTVAIRAT--LDDGVYGVAQV\n",
      "LVTPASEPGVADAPVFSLEPGLYESVEAV-SITTGTPDAEI---------RYTTDGSVPT\n",
      "ADS--------------------------TLYTGQIVLAPLKTTYLRAI----AVGDG--\n",
      "--LEDSGVTSRLY-KVRDVQNAP-----------DGYAFCQYQ-----------------\n",
      "------DRG--------------------------------------VCAFEGEAS----\n",
      "-----------------VAFGSDGL------------------------FRYGTFTGGVD\n",
      "CTAASFGGDPNPDGDNRCFVNPDVPDEQPIVTIYNAGFERPATGGTSNGPMVN-------\n",
      "---GWTFSARAGIQHNNS-------VFQPA------------------------------\n",
      "-----------------------------------FPAPQGER-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAYLKSDSGLASR-------------------------------\n",
      "------IDQTVRFPAG--------------TFAITFAAANRVGF----------------\n",
      "--------GGQQEFDVLVDDQKLGHFVPTRDGKYTAYET-----EPFTVAEGEHTISFVA\n",
      "TTTEG-----DNTGFVDDVQVIAAGT-----PDPEPDTV----------KPVVT------\n",
      "--LTAPTTA---------------------------------------------------\n",
      "------------------------------GPHR--------------------------\n",
      "-----------SLELKVDAT----------------------------------------\n",
      "-------------D-DRGLARIVANVYRDGT---------------------LVKSTQTA\n",
      "V------------------------DGAAAATHAASVTLPDGTYTVRYNAHDLA------\n",
      "-----GNV-AQTKTFDVTIDATAP------------------------------------\n",
      "--------------------------------------------------TVTVKDGA--\n",
      "-------SFTARDGDDYSLVSFKLRDAGKIDKAVLNGVTKDLTDNAWSDVNFVKP--GVF\n",
      "G--------AVPGANTLVVHDV--------------------------------------\n",
      "------------AGNT--------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------------------TTVE---------\n",
      "----------------------------------------------------FTLR----\n",
      "------------\n",
      ">BAJ75160.1_Microbacterium_testaceum_StLB037_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MT-----SPHPLRRWTALTT------------------------------------\n",
      "----------------------------------------TGAVIASLAV----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------AGSVSSAAAD----TSATVTI---DTGTVV--\n",
      "QDDFLGIGVNVIPS-ALMERSR----------GFGY-SDADW-AIDAERIATIRPKVARV\n",
      "WFQIDWM--EPDKGV----------YTW------DSDRMKAFYKYLDAFKAAGT-DIELN\n",
      "FGWKVGST-----------VHDWFGIPGV-----DP----WTSAPADNAAYAASASALID\n",
      "QLKNVRGYDNVKYLTYYNEPNGS--WDFEA--------PG-DQ-------QAAYVQMAQA\n",
      "VHQRLVAD-GLR--DEVEIWGPEET-----------------------------------\n",
      "------------GAPAWTTYMAQ-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NGGD-AFDQ-----YSFHTYGDSY-------------GSVPASI----------\n",
      "---NARKSVA-------GGKPVNMSEFGWSDDN-------------------------AS\n",
      "GWD-----------------S-GYANYVIAGANLGLHSLLVWQLNGTWTVD---------\n",
      "-------------------P----DGD-----TNGTYN----MWDA--------------\n",
      "-------LPLGLEPRKTFLSAGLLNRYIP-AHSQVLQSSS-ST-----------------\n",
      "----------------------------------------------------SDVRTAAF\n",
      "R--------DAAG---EYTVLVEAKG-TAPTDLDVSFGTT-A----VNKDFHRVVYANDL\n",
      "V----------PDKNA---------LLPTVSATLPAAT-GF-SDQ-LDDGYSFAIYTTAA\n",
      "PAVQVRLGDVDPSVASGSTLPLT--AEVLDGA----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----PGVTWSVE----GTGNGSV-TSAGVFTPPVVDSERTVAVRATSTADPSSSAVARV\n",
      "TVTPQLTAGRVDPVQFDLDSGVYAGSEVL-TLSTPTSGAQI---------RYTTDGSAPT\n",
      "ANS--------------------------TLYERPLILAETSTKLYRAA----AFATG--\n",
      "--KQDSGVTSRLF-KVGGVSQGP-----------DGYTLCANE-----------------\n",
      "-------GG--------------------------------------TCFFSGQQS----\n",
      "-----------------VAFGGDGL------------------------FTYQAKTGPVS\n",
      "CDAATL-GDPNPNGTQRCYVSPELPSSYPLVTLTNAGFEKPGGTKSKTGPFTN-------\n",
      "---GWTFNSRSGIQNGQG-------PLGPP------------------------------\n",
      "------------------------------------TPSEGQQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------VGYLKTDAGVQGT-------------------------------\n",
      "------ISQEAAFPAG--------------EYQVVFALSGRSGY----------------\n",
      "---------PAQSFDVLYDDSVIGSFSVGSTSSYETKRT-----PAFTSAGGRHTITFRA\n",
      "TAPSG-----DRTAFLDAVRIE------------APVP------------PEPA--QLQN\n",
      "TGFEAPATT---------------------------------------------------\n",
      "--------------------------GVKSAPFT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------EGWS------FVGRSGIQHNGSAFG-APT--------------APEGTQTA\n",
      "LLQS---------------------RNGEHGSFTQTLDMAAGDYTLSYQASRR-------\n",
      "-----PGY-SAVQTVQVLVDGVVV------------------------------------\n",
      "--------------------------------------------------DSFAPPTA--\n",
      "-------TFTAHTSATFTVPA------G------------------DRQITFRGS-----\n",
      "---------APSGDATAFVDQVVLTPVP--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">BAJ74095.1_Microbacterium_testaceum_StLB037_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MR---------RRRTALALTAT----------------------------------\n",
      "----------------------------------------TSVVAAALLV----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------PATAASAAD----EQRTVTV---HLDQTV--\n",
      "QEDYLGVGVNVIPW-SLLEGTT----------KYGY-DDADW-EVDVERIHTLQPKVARI\n",
      "WFQIDWM--ELEKGR----------YDF------ESPEMKAFYRYLDAFKAAGT-EIELN\n",
      "FGWKVGAR-----------VHDWFTIPGAP----DP----YISAPADLPAYGASASALLQ\n",
      "NLFD-RGYDDVDHLTFYNEPNGS--WDFWA--------PG-DE-------KAYYADMARA\n",
      "VSDRLTAD-GLR--DEVDIWGPEEV-----------------------------------\n",
      "------------NAVAWTQYMAE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NAGD-VFDQ-----YSFHLYGESY-------------DAMGDAI----------\n",
      "---AQRRAVI-------GDAPLNLSEMGWTNPG-------------------------TS\n",
      "VWE-----------------T-GYANYIIRSANDGVHSNLIWQLNGVMTGD---------\n",
      "-------------------P----AGD-----TNGSYN----LWDS--------------\n",
      "-------LILGLEPTAAFSEAGPLMRYVP-TRSTVLGTEI-SD-----------------\n",
      "----------------------------------------------------ADVRATAF\n",
      "R--------APDG---ELTVLVETQS-GSSKDVRVQFEGG-D----AAGDFTRIAYTDAI\n",
      "A---------QPGENA---------LLPASSGTLTPDANAF-TDTEIGDEHTYAIYTTAP\n",
      "AATQVEMTPVRTSVAGGSRVQLG--ANVIDGT----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GTPTWSVV----GSDNGTI-DANGVFTAPSVTTERTVAVRAT--LADGEYGVAQV\n",
      "EVTPASTAGVTDAPVFSLERGVYDSIEAV-TITSATPDAQI---------FYTTDGSEPT\n",
      "ASS--------------------------TPYTGQIFLEPLKTTYLRAV----AVAPG--\n",
      "--ADASGVTSRLY-KVRDVQNAP-----------DGYSFCQYA-----------------\n",
      "------GGG--------------------------------------ECAFEGEAN----\n",
      "-----------------VAFGSDGL------------------------FVFGTFTDGVD\n",
      "CAVASFGSDPNPGGDNRCFVNPDVSEEPPLVSILNAGFERPATGGTANGPMVN-------\n",
      "---GWTFSARAGIQHDNS-------VFVPA------------------------------\n",
      "-----------------------------------SPAPQGER-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAYLKSDSGLASR-------------------------------\n",
      "------IDQTVVFPAG--------------TFAITFAAANRVGF----------------\n",
      "--------GGQQEFDVEVDGQKLGHYVPVG-GDYRYYET-----APFTVTQGEHTISFVA\n",
      "TTTEG-----DNTGFVDDVRVVAA--------EEEPG-----------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------DTTAP------------------------------------\n",
      "--------------------------------------------------TVTVKEGA--\n",
      "-------AFTQGTAEAYDKVSFKLYDEGKIDRAVLNGVVKDLADNTWSDVNFVAP--GVF\n",
      "G--------AVSGENTLVVSDV--------------------------------------\n",
      "------------AGNS--------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------------------TTVT---------\n",
      "----------------------------------------------------FTLR----\n",
      "------------\n",
      ">AHF17862.1_Niabella_soli_DSM_19437_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK---------SINMIKNT-------------------------------------\n",
      "----------------------------------------FILLTLVVLM----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AN------------------\n",
      "-------------------CSKGSASN---------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------KGTDNGGEA----PGEQVTI---DVTKTV--\n",
      "SANFAGFGTQYNQN-VYAAISAV----------DGI-TTANI-GQLEAKVKALKSRYVRI\n",
      "FFDSRAW--PADPGY----------STA------TADFMTSFLKTVQLAQDGGAATINIT\n",
      "F-W-----------------------------------------HTSTPEEMPAFADILK\n",
      "ELIVTRGLSSVKEVTIQNEPNST----------------SMT--------MDYYKTCYTA\n",
      "LDQALTIR-GIR--NKINFVGGDLVQT---------------------------------\n",
      "------------NQQAWFGYLAA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NMGD-LLSG-----YSTHIYWDDN-------------DAAK-----------PM\n",
      "TRLTEVAAIVK--APGSANKPVYITEYGVRGGN----KTGA-PDPGYLTGTSTPI-----\n",
      "-------AQTPV-------AAMQNALFQINGLNLGFSGFIRWDCYKAKYDN---------\n",
      "-------------------------------------GT--QYFSCIGS-----------\n",
      "-------GTDGYPLYPLYYMTWLFNHTSE-PGWRVVSSYP-TAG----------------\n",
      "----------------------------------------------------DNRPIIAA\n",
      "AM-----INATAS---EQTIYVINKS---SGQVAYTAGGL-I----PNKKYTVCSFNNNN\n",
      "NGQLEKSE-ATAGGDG-----------------------KI--LHTI-KPNSFVAITTYD\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------LTLP---------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">AHF89993.1_Opitutaceae_bacterium_TAV5_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MT----------CSESS---------G-----------------------------\n",
      "----------------------------------------IRVPVFAILVACLPF-----\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------------FSSRPLV-------\n",
      "-----------------------------AQDKPSPDA----RQERLVVAETTGINPL--\n",
      "DGPFIGFGAQWDST-AYIRN--------------GI-TDADF-DLIEKRLGWMRTPIVRM\n",
      "MMVSGWCY------QGNGR------YDW------DSPQMRMVLRQLDVCQKLGI-SVILT\n",
      "E-WGYNTR-------------------WMRT---------PEVSDIGDPKHVEIIGSYME\n",
      "YLVKTKGYSCIRYFGYVNEPSSS--YAQKQ---------------------DLWLQGIDG\n",
      "IAAEFRRR-DLA--DKVRLVGPDSASLAL-------------------------------\n",
      "---------AMFDRKSWLAPLQ--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------KRAA-SVGA-----YQFHTYIVLE-------------DMRRGGL---------K\n",
      "DLYSEAWRQVREGDP-DKTKPLIIGEAGIWKWG-PT-RETKT----------------GA\n",
      "DNNAWNREDPWA-------YGIYMAEYAIQAIEAGSWGVLAWMLDDNSHYGF--------\n",
      "-----------------------------------NWG----MWTS--------------\n",
      "-------KKDGMQLRPWFYTWSLLSRSFP-PGSEFSKVYP-PP-----------------\n",
      "--------------------------------------------------VYSNMRILAA\n",
      "KLPVRTGDAKQAGAGREWAFLIVNTG-TSHSRIRVRVPGG------HVQKSDVYSWSRNA\n",
      "A---------SADADG--------FPRPSTT-LESSLDEGF--PMSF-PPQSVTIVVPQG\n",
      "RDERI-------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">AHF91408.1_Opitutaceae_bacterium_TAV5_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MH------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------HKNHVSL--KLAAAPV--\n",
      "HRMQSGVGASWHSI-LNAPVGHGGSAFGGQPPVLPV-HEPLW-RSIEAQADWLKLRFIRL\n",
      "EFEWRQF--EPRRGE----------FTW------DSPGMRILDRICAWAERAGA-DVMLQ\n",
      "QQWGGVA---------------WNSFPEFRG---DP-AMETYSAPADLHAFADGWMRLLE\n",
      "ELSVRRGYRCIRWINPINEPGYW--WWHLPESYRLLRVEG-NREASRRLQLSYLAEACAI\n",
      "LRRRLRAE-----HPAVRLMGPDETDLPVY------------------------------\n",
      "---------ERLAAEPWFA-----------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------AVDD-----VDFHSYNSVFDH-----------EPLPAAW-NYHIGDRID\n",
      "SLVRRYCDEAH-----AAGKGLFLTEVGSMAYGY--------------------------\n",
      "-GADNPAPGCHL-------SSLKDVEVLIRSLAAGVDGFSHWSFTNRGDID---------\n",
      "----------------------------------GQWQLV-DTWSIEHKNW---------\n",
      "-------LPEARPHRPAFDVLGRAMRHVP-KCARIFPVEV-DGG----------------\n",
      "RIGQP--------------------------------------------PH-RRVWAVAA\n",
      "Q-------DPSTG---VTRLLVVNNA-EEPFEFTLSLPET-R------------------\n",
      "-----RGDGTASDAGAGAWSVLD-PCSDKATPLDRSLRDSRCRSGVL-PPRQLVILSNGA\n",
      "ATPEER------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------------------------SLPAR--\n",
      "------------YLPQHDIAKRP-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------ANASDS------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------------RLAPSHLH-----------------\n",
      "------------------------------------------------------------\n",
      "---------------PSSVIQS--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------AIP------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">WFR61027.1_Paenibacillus_amylolyticus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK-----SRS-GRLASRWAI------------------------------------\n",
      "-----------------------------------------PFLISTMLA----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------SF------------------\n",
      "-------------------VPAPSLIY---------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------ANQNESQNLNR----TSHTITM---DTSDVI--\n",
      "QDDFLGVGVNTIPT-ALMPGQT----------QYGY-SEAHW-EVDNKRIQTIQPKVARV\n",
      "WFQIDWM--EPAKGT----------YTW------DSAKMKAFYKYLDAFKAAGT-EIELN\n",
      "FGWKVGST-----------VHDWFTIPGI-----DP----WTSAPADLDAYAASASALLE\n",
      "ELILNRGYDNVKYLTFYNEPNGS--WDFEA--------PG-DQ-------KAYYAEMVNK\n",
      "TSARLTAD-GLR--DLIEIWGPEET-----------------------------------\n",
      "------------GAPAWIEYMKQ-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------HADD-AIDG-----YSFHVYGESY-------------EGLGNAF----------\n",
      "---ALRKGYV-------GDKPLHLTEFGWADDQ-------------------------AS\n",
      "NWD-----------------A-GYANSVIQTANMGVKSALMWQLNGVWTND---------\n",
      "-------------------P----TGG-----TNGTYT----MWDA--------------\n",
      "-------LVLGLTPRKTFYIAGMLNRYIP-EHSEVLAVDTGGS-----------------\n",
      "----------------------------------------------------NDVRAAAF\n",
      "R--------GDDG---NYTVLVETKA-GTEKEIKLDFGDT-A----VNQAFRKFVYNNDI\n",
      "V----------QEANA---------VLPPVAATFPGGT-SL-TDSNVDGDYNVIIYTTRP\n",
      "AETQIKLDEVNPTVRSGDSITLG--AEVIDNT----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GSVTWSVV----GQNNGTINSSSGVYQAPQVTDETLIAVRATSTADPSAYGVALV\n",
      "RVLPSSQAGKVEVPTFSLDRHIFPSSEML-YLETTTSGAQI---------RYTTDGSEPT\n",
      "AQS--------------------------SLYVRPIVLNEGSLALYKAK----AFKDG--\n",
      "--LQPSGTVSSLY-QIGQISSAP-----------DGYKLCMIE-----------------\n",
      "------NGG--------------------------------------ECYFQGKAV----\n",
      "-----------------VAYGADGL------------------------FNYSIQENGVA\n",
      "CTSAIL-GDPIPGVDKRCFVNPEIPDELPVVTFFNAGFEKPATTSARPGPMTN-------\n",
      "---GWVFDSRSGVQHNNG-------PFQAT------------------------------\n",
      "------------------------------------AAPQGVQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TGYLKTDGGVSGT-------------------------------\n",
      "------IRQSIHFKPG--------------TYQMSFKAAKRTSF----------------\n",
      "--------GGTQSFDIYFDDQVIGSYRPES-GNFQTFRT-----EPFETAGAN-------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------------------------TR-------\n",
      "-----SNL----------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ANF97338.1_Paenibacillus_bovis_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MN-----KKA-RSAFSIMGT------------------------------------\n",
      "-----------------------------------------SILLLSLIL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------PS------------------\n",
      "-------------------VSAPSQ-----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------AKAAEPTAATA----VTRTISI---DPDKVT--\n",
      "HSDFLGVGVNIIPT-NTMDLGA----------RYGY-NDAYW-AMDVNRIQKIQPKVARV\n",
      "WFQIDWM--EPEKGQ----------YTF------DSPKMKEFYRYMDALQSAGT-EVELN\n",
      "FGWKVGKT-----------VQDWFNFPNLK----DP----YVSAPTDLNAYAASASAALN\n",
      "ELINKRGYDNVKYMTFYNESNGS--WDFEG--------PA-DQ-------KAYFAEMSRK\n",
      "VSDRLKAD-GLR--DRIEIWGPEES-----------------------------------\n",
      "------------GALDWISYMKQ-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NADS-VFDA-----YTFHVYGTSY-------------DGLKSVV----------\n",
      "---DQRTSIA-------GSKPVVMTEFGWSADD-------------------------AS\n",
      "GWD-----------------A-GFANSIIRAANDGLKGALMWQMNGAWTSD---------\n",
      "-------------------P----DGD-----TNGTYT----MWSS--------------\n",
      "-------LPLDRMPRKTYYSAGFLNRYIP-EHSDVLAVDTGGA-----------------\n",
      "----------------------------------------------------SDVRAAAF\n",
      "K--------GQDG---NYTVLVESKG-GEARNLNIDFGDN-T----INKTFYKMTYRDNV\n",
      "N----------IDANA---------ILPQVEKAFAATR-SF-TDNDSDTAYHFSIYTTAK\n",
      "PQTQVEVTPVEKTVTGAGTLQLQ--ARVIDATYNGQ--AAVTEDTYATENTAN-------\n",
      "------------------------------TDASTTRSTDTDASEAAALGEVT----TLA\n",
      "DQADSAASQASDRTDSGDSSVQVAGQS-AAIADSTDVQAASSENTVNADTYAADD-TQQS\n",
      "LA-AAGGVTWTVL----GTNNGTI-DANGLYTAPDLASERMIAIKASSSQATGAYGIALI\n",
      "KVIPRSVPNRVDAPTFSLKPGTYDSAEAV-FIETKTPGAQI---------YYTMDGSTPT\n",
      "ASS--------------------------SLYKYGAILPNGGNRMLKAI----AIKPG--\n",
      "--LDNSGITAALY-KTKDVAMGP-----------DGYEFCMYE-----------------\n",
      "-------GK--------------------------------------VCDFKGKAM----\n",
      "-----------------VAYGADGI------------------------FKYKTFTDGIE\n",
      "CTDESFGGDPAPGSAKRCFFTNTIPDETPVVTIFNAGFEKPGTETTRTGPFTN-------\n",
      "---GWTFDSRSGVSANGS-------QLVSK------------------------------\n",
      "----------------------------------DIKAPQGLQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------VGYLKTDGGVNGT-------------------------------\n",
      "------ISQQMNFPAG--------------TYELSFDLATRSGY----------------\n",
      "---------GIQTFDVYMDNQKISSHTADS-VNFQKVTT-----RPFTVTSGKHTVKFIA\n",
      "TSADPALPKLDRTAFLDSLFIR-------------PAN------------SLPA--QLKN\n",
      "GGFETPVIA---------------------------------------------------\n",
      "---------------------ADSKAKTKPGPFT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------SDWV------FDSRSGVQGNNSVLG-SVT--------------IPEGAQSA\n",
      "YLKT---------------------DNGVNGTITQKLKFPQGSYTLSFKAAQR-------\n",
      "-----TNL-RGTQKFNVMLDNQVL------------------------------------\n",
      "--------------------------------------------------GSYTPASG--\n",
      "-------AYEAFTISPFTVTA------G------------------EHTIQFVAT-----\n",
      "---------STTGDNTAFIDDVKLAPVQ--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">WPP43235.1_Paenibacillus_hunanensis_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MN-----RQA-RTMWRTLGV------------------------------------\n",
      "-----------------------------------------QVMTLALML----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------PA------------------\n",
      "-------------------FTWG-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------SADTNRAEAAT----VSRTISV---DTSQVV--\n",
      "QSDFLGVGVNIIPT-NLMELGT----------RYGY-NDAYW-AMDANRIEKIQPKVARV\n",
      "WFQIDWM--EPQKGT----------YTF------NSDKMKAFYKYMDALKTAGT-EVELN\n",
      "FGWKVGST-----------VQSWFNIPGLK----DP----YVSAPADLDAYAVSASAALN\n",
      "ELLNQRGYNNIKYLTFYNEPNGS--WDFEG--------PA-DQ-------KAYYAQMVQK\n",
      "VHNRLTAD-GLR--DRIEIWGPEET-----------------------------------\n",
      "------------GALDWMQYMKN-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NADS-AFDA-----YTFHVYGTSY-------------DGLGNVI----------\n",
      "---SDRHAAA-------GSKPVVMTEFGWADDD-------------------------AS\n",
      "NWN-----------------A-GFANSVIRAANDGLRGALMWQMNGAWSSD---------\n",
      "-------------------P----DGD-----TNGTYT----MWHS--------------\n",
      "-------LPLDRDPRKTYYSAGFLNRYIP-EHSQVLKVNTGGA-----------------\n",
      "----------------------------------------------------SDVRASAF\n",
      "R--------GADG---NYTVLVESKG-DSAQQLTIDFGNT-S----INKTFYKMTYRDSV\n",
      "Q----------PNAQA---------TLPVVENTFAAQK-SF-IDNSTDTGYHFSIYTSAK\n",
      "PQTQVEVTPIEKTVTGGQTLQLQ--ANTIDATYGNTSVAAVTEDTYGTETDSDSTSSETM\n",
      "KSSTAEGTRSNADEQAVAALSASEQVTSTVTASSVSKSGDSTANAVAASSEATATEQATT\n",
      "DQATANTQAPDESTTSSDAKVDTDKEKGTAVADQTSATEQSAPSSEEASATEAESVTEST\n",
      "YTLAATNVTWTVL----GSNNGTI-TSNGLYTAPDVSTERMVAIRATSSTAPGAYGIALI\n",
      "KVIPRHVDTRVDAPTFSLTPGIYNSAEAV-FIESATAGAQI---------RYTLDGTTPT\n",
      "ASS--------------------------TLYSNSVILPNGGTRMLKAI----AIKSG--\n",
      "--LTNSGVTSGLY-KTLDQSIGP-----------DGYQFCAYE-----------------\n",
      "-------SK--------------------------------------TCSFNGQAM----\n",
      "-----------------VAYGADGI------------------------FKYKKLTDGAL\n",
      "CTDEVFGGDPAPNAAKRCFYTTTIPNEVPVVTIFNTDFEKPETSSIKPGPFTN-------\n",
      "---GWVFDSRSGVQRNGS-------AFGAA------------------------------\n",
      "------------------------------------TAPSGQQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAYLKTDGGINGT-------------------------------\n",
      "------MSQQLNFPAG--------------TYKLSFQGATRSGY----------------\n",
      "---------GIQTFDVYVDSQKVGSFAPQS-SSYTTLTT-----NAFTVTAGKHNVKFVA\n",
      "TSNTG-----DHTAFLDSMIIREAS------STPDPEP------------PVTG--ELKN\n",
      "GGFETPAIA---------------------------------------------------\n",
      "---------------------SSSSTKTRVGPFT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------SDWV------FDSRAGIQGNGSVFAPAAN--------------APEGTQTA\n",
      "YLKT---------------------DNGVNGSIQQQLTMAAGTYKLSFKGAKR-------\n",
      "-----TNL-GGTQTFDVYVDSNKV------------------------------------\n",
      "--------------------------------------------------GTFAPNSG--\n",
      "-------IYTSYTTSAFTVTA------G------------------QHTIRFAAT-----\n",
      "---------STTGDNTAFIDDVKLTAQ---------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">ANY71428.1_Paenibacillus_ihbetae_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MTSK-------KSMFALCRK------------------------------------\n",
      "-----------------------------------------GLLCAALLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------SS------------------\n",
      "-------------------IGAGT------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------AAADSSLADSP----ASHTVRI---DPGTVI--\n",
      "QEDFRGVGVNVIPS-SLMPGTT----------QFGY-TDTDW-EIDKKRIVAMKPKVARV\n",
      "WFQVDWM--EKTKGS----------YDW------ESAEMQAFYKYMDAFQAAGT-EIELN\n",
      "FGWKNGSA-----------IHDWFVLPGV-----DP----YISAPADLGAFARSASAALS\n",
      "ELIDGRGYDNIKYLTFYNEPNGN--WDYET--------TG-DQ-------KAYYAEMVRK\n",
      "VSQQLSTD-GLR--DRIEIWAPEET-----------------------------------\n",
      "------------GAPDWTAYMAE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------HASE-HIDG-----YSFHVYGASY-------------ESVTAAM----------\n",
      "---NERIQAA-------AGKPVHLTEFGWSDDG-------------------------MS\n",
      "GWD-----------------A-GFANHVIQAANMGVKSALVWQLNGVWPTD---------\n",
      "-------------------P----FGD-----TNGNYT----MWDS--------------\n",
      "-------TVQGMTPKKTFYSAGLLARYVP-AHSTVVKVDT-GS-----------------\n",
      "----------------------------------------------------PDLRAAAF\n",
      "K--------TERG---DYTIVLESKA-GSRKEITFDFGGV-K----INKTFRKFVYSDDV\n",
      "I----------RDGNA---------LLPSSSGAFKAKS-SF-RDTSIGPDYNVIVYTTEA\n",
      "PQTQIKLTPIEATVAGKGTIQLS--AELLDNN----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GAVKWSVIG---GEGNGTI-SSKGLYTAPDVATQRQVAIKAASSKDPASYNIAKI\n",
      "TVTPASTPGKVDAPVFSLPYGVYDSAEAV-TVTSSTPGAEI---------RYTTDGSIPT\n",
      "ASS--------------------------RLYTGPVILNNGTVQLFQAI----AIKPG--\n",
      "--MQDSGVTSAYY-RIRDISNAP-----------DGYQFCTYE-----------------\n",
      "-------GG--------------------------------------FCDFEGEAV----\n",
      "-----------------VAYGAEGL------------------------FNYAIHADGAA\n",
      "CSDEVF-GDPSPNSAKRCYYSKEIPEELPLVTFYNAGFEKPATGNTRVGPFTN-------\n",
      "---GWVFGDRTGIMHNGS-------VFENP------------------------------\n",
      "------------------------------------DAPQGVQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------AAYLKTDGGVAGQ-------------------------------\n",
      "------FSQRIQFKEG--------------TYQMSFQAAKRTSF----------------\n",
      "--------GGLQTFNVYFDDTVIGSYAPSS-GTYMTFTT-----DTFTASAGEHTIKFVA\n",
      "TTAEG-----DNTAYIDDIRIG------------SPQP------------PKAP--AFAN\n",
      "AGFESPSTS---------------------------------------------------\n",
      "--------------------------GAKAGPMT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------DGWV------FNNRAGVQRNGSAFG-AAE--------------APEGIQTG\n",
      "LLQS---------------------KDGEQAEIKQSLYFPAGSYSIRFQAAKR-------\n",
      "-----GGF-GGLQSFDVYVDDTRI------------------------------------\n",
      "--------------------------------------------------GSYQPATT--\n",
      "-------AFEAYTTDVFTVSS------G------------------NHTVTFRAT-----\n",
      "---------TTAGDNTAFIDDVQIVVP---------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">WCT54208.1_Paenibacillus_kyungheensis_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK-----KKA-RSVCSSIGI------------------------------------\n",
      "-----------------------------------------AILMLSLLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------PC------------------\n",
      "-------------------FQSPL------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------LAATSTAASAE----INRTVTI---NTSNVV--\n",
      "QSDFLGIGVNIIPT-NLMALGA----------KYGY-NDAYW-AMDTQRIYQFQPKVARV\n",
      "WFQLDWM--EPSKGT----------YTW------NSEKMQKFYQYIDALKASGT-EVELN\n",
      "FGWKVGSS-----------IQSWFNFPNLK----DP----YVSAPTDLPAYARSASALLN\n",
      "ELINKRGYDNIKYMTFYNEPNGS--WDFEG--------PT-DQ-------KAYFAQMSRA\n",
      "VSEQLKAD-GLR--DRIQLWGPEET-----------------------------------\n",
      "------------GALDWTQYMKQ-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NADD-VFDA-----YTFHVYGASY-------------NDLGARI----------\n",
      "---AERKSAV-------GSKPIVMTEFGWGDDN-------------------------AS\n",
      "NWD-----------------S-GFANSVIRAANDGLQGALMWQLNGAWTSD---------\n",
      "-------------------P----DGD-----TNGSYT----MWDG--------------\n",
      "-------LPLGLKPNKTYYSAGLLARYVP-EHSQVLAVNTGGA-----------------\n",
      "----------------------------------------------------SDIRAAAF\n",
      "K--------AKDG---NYTIVLESKS-GQSKNVTFDFGTT-T----IGKTFYKMNYQDDV\n",
      "Q----------RDGNA---------LLPAVENSFTANQ-SF-TDSAINSEYNVSIYTTAK\n",
      "PQAQVKMTPIESTVASGSTLTLN--ATVIDASYSQTSVAA---DTYTT------------\n",
      "------------------------------------------------------------\n",
      "-----------------DDILPVTEND-VKTKEKQDIFNNYSTTTATSDTYVTPA-EEYT\n",
      "LASASTDVTWSVV----GSGNGTI-SSTGVYSPPDVTTEKLVAIKATSVADPKGYGIALI\n",
      "KVIPQSIASRVDATTLSLKAGVYDTSEAV-TVKTGTAGAEI---------RYTLDGSVPT\n",
      "TSS--------------------------SLYTKPVILPEGGTKVFKAK----AFKSG--\n",
      "--LTASGVTSALY-KILQNSTGP-----------EGYQFCMYE-----------------\n",
      "-------GG--------------------------------------TCSFDGTAS----\n",
      "-----------------VAYGADGL------------------------FKYGTFTNGVA\n",
      "CTDEAFGGDPTPNLPKRCYYTNDVPEQTPVVAIYNTGFEKPTVSTTKTGPFTS-------\n",
      "---GWTFDSRSGVQRNGS-------AFGAT------------------------------\n",
      "------------------------------------TAPEGQQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAYLKTDGGVAGS-------------------------------\n",
      "------ITQQLNFPKG--------------EYKLSFKAAKRTSF----------------\n",
      "--------GGTQTFDVFVDQTKIGSYAPTS-GNYTTYTT-----NAFT-ANGKRTIRFVA\n",
      "TTTTG-----DNTAFLDQISIQLAS------DISVPPS------------NPEA--VIAN\n",
      "TSFENPATT---------------------------------------------------\n",
      "--------------------------NTKVGPFT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------SDWV------FSTRSGIQRNGSVFNPAAN--------------APDGVQTA\n",
      "YLKT---------------------DSGVAGSISQSITFPAGTYALTFQAAKR-------\n",
      "-----TSV-GGTQTFDVYVDNKVV------------------------------------\n",
      "--------------------------------------------------GSYSPTSG--\n",
      "-------TYTSYTTNNFVVTA------G------------------EHTIKFVAT-----\n",
      "---------TSTGDNTAFIDQVKLIQK---------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">AYB42811.1_Paenibacillus_lautus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MS---------KERRWLGGIL-----------------------------------\n",
      "----------------------------------------SFFIFAGILT----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------TPTSIQAED----NVSTINI---DTTSVV--\n",
      "NSDFLGIGAEYDPF-HFMPESV----------EAGF-NEHWW-EMEKRRLAKVKPNLVRV\n",
      "WYQIDWM--EPANDNNDPNI-----IDWS-GMQTESVKMQAVYRVLDYLKAQDI-DVILV\n",
      "AGWKMNAD-----------VRSWLGFSGL----QKP----ETSAPTDLNEWAEWVSATLQ\n",
      "QLIVNKGYDNIKYVMSYNEPNLGD-FETPA---------SINQ-------KEYYEDMYRA\n",
      "IHNRLVTD-GIR--SEVKLLGPDES-----------------------------------\n",
      "------------SGLDWMQHAVQ-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NMND-ILDI-----YEGHAYGKEY-------------DTMDSWT----------\n",
      "---TERLALVE-----PTGKPLMTTEFAAPGDK---------------------------\n",
      "--------TTYQ-------NAVELADLMVSGMRSGNSGMLMWRLADQFLVD---------\n",
      "-------------------PL--------NFLDSSAYG----TWPW--------------\n",
      "-------LPDSAVPRYTYYTFSLFTRFGG-AHSQVLLTET-DD-----------------\n",
      "----------------------------------------------------PDLHVTSL\n",
      "K--------RLDG---EYSVFVVNKSLHSSKSVSIEFSNH------VGKTFRRHLFSDAI\n",
      "T---------PTASAT---------IIPSDTLWNSVAT-SF-NDASI-PANSVAVYTSVP\n",
      "EPVQIEIAPDEVSAAPGASITFE--GNVYGAA----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----PGIEWSVAG---GPTYGVI-DNQGVYTAPAIVPSMPEALVKAKINGEQDFAVIRF\n",
      "QVTGASALGDDGSIKLNWSPSMGASGYNV-------------KRSQTRGGPYSTIAGQVS\n",
      "ATE---YIDAG--------------------------LANGQTYYYVVS----AVSST--\n",
      "----GEGADSK------EVSAMPTSNA-----MEDDF--------N--------------\n",
      "--DNQIDSA---------------------------------KWSVINRGLRSSLPTQ--\n",
      "----------------IVASEANGVL----------------------------------\n",
      "------------------------------------------------------------\n",
      "-----TFNGSTGINYWSGKAVESVLPFHAS------------------------------\n",
      "-----------------------------------ATEPLTVQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------VDRISLSGTGTGQ-------------------------------\n",
      "------RSGLWLYVSG--------------SEYLRFSQNKDTGV----------------\n",
      "WA--YNLNGGSDTL-VLADNNL-----------------------------GNHEMKLVH\n",
      "DGSHVH---I----YVDDIKYK-----------SVP------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------VAWS-----------------------------------------------\n",
      "-----------------------------------------SNMKVVLSAEAR-------\n",
      "---------ADGDSIQVVYDNLSV------------------------------------\n",
      "--------------------------------------------------SS--------\n",
      "---------------------------GSP------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QGG55106.1_Paenibacillus_sp_B01_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK------AV-EERLDGAGGLD----------------------------------\n",
      "-------------------------------------GERMAAALDRAAV----------\n",
      "------------------------------------------------------------\n",
      "-----------------------------ET-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AA----GHE-GP--------\n",
      "-------------------AAVGAEYSG--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------LVAEAAP---------\n",
      "-----------------------------VVGRLDAAA----AAWTVRI---DADDVL--\n",
      "VGDFDGIGFEWDPC-DTYEH-----------------TDEQW-ETLLERVDFTRTPLVRV\n",
      "MLRANAYT-AGWDGRGEPV------YDW------ETPMMRRLWRILDHCERRGI-DAIVG\n",
      "E-WSRSPE-------------------LGLT-------------ASDDPAWAELIGEFLH\n",
      "QLLDVRGYRCARWYNFINEPNGD--WATED---------G-DR-------FALWRRGMLQ\n",
      "LAQVLERR-GLA--GRIGLIGPDSS-----------------------------------\n",
      "------------NEDEWVELAVY-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GVGG-LLSA-----YDIHRYVQDA-------------DLISGRL---------E\n",
      "RQVREKRRFIDRNDPDGAAKPYLMTEAGIVEGK-------------------------NE\n",
      "AHDQQPRVRTFE-------YGVLMADFALQAMRGGQSGLIAWMLDDVMHHA---------\n",
      "------------------------KGYPWSSGEWKTWG----FWNSSG------------\n",
      "-------DAQERALRPWYDPMALLSRLFP-RGSRIVAASV-WDDEGTGGAGPGTGGSGGV\n",
      "SVGEPGAGGVGGAGGAGPETGGSGSVSVGEPGAGGVEGAGGAGPGSWREPVLAGVRGVAA\n",
      "L-------VPLDGGGRGWSAAIVSHR-QGRQSLRLVLPQA-S----GGADLAVYRCSERE\n",
      "R---------SADADG--------YPAPALTLSGADAARGI--ELEL-YGPGVLFVTTAM\n",
      "PEDGP----HGRQTASRQTTLAAA------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------------GREP\n",
      "QRPEAFGLSWGVQP----------------------------------------------\n",
      "---------------------------------------------------FAGEGDLAR\n",
      "GRPA--------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------SGS-------------------------------------ISLHHRGSGPEC--\n",
      "--------------------AVDGL-----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------RHTA-----WRTRVR-------------------\n",
      "------GEHEIAVRLDGLRRIG--------RVKLEWGEGCPSRY----------------\n",
      "------------RLEASADGANWTAVLERNGEEANMRLNHLASDTSASGGAGAEELAFPT\n",
      "IEAAH-------------VRLAAI----------RPAG---------------------T\n",
      "LGLELRRLS---------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------V--YGPDAASADVPAAEAGAGGGGVAASPREASDPRDASDSSDPADAPDSTDAA\n",
      "SAA---------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------G--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------------APKG-----------------\n",
      "------------------------------------------------------------\n",
      "----------------G-------------------------------------------\n",
      "-------------GRR--------------------------------------------\n",
      "------------\n",
      ">WJH29034.1_Paenibacillus_sp_CCCFT742_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK-----SKS-GYRTSRWGI------------------------------------\n",
      "-----------------------------------------SLLITTMLT----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------SF------------------\n",
      "-------------------IPVSPQAYA--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------AVQNQNQSQNENS----TSHTITI---DTSDVI--\n",
      "QDDFLGVGVNTIPT-ALMPGQT----------QYGY-TEAHW-EVDKKRIQTIEPKVARV\n",
      "WFQIDWM--EPTKGT----------YTW------DSAKMKAFYKYLDAFKTAGT-EVELN\n",
      "FGWKVGST-----------VHDWFPIPGI-----DP----WTSAPADLDAYAVSASALLE\n",
      "ELIHNRGYDNVKYLTFYNEPNGS--WDFEA--------PG-DQ-------KAYYAEMVNK\n",
      "TSARLTAD-GLR--DLIEIWGPEET-----------------------------------\n",
      "------------GAPAWIEYMKE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------HADD-AIDG-----YSFHVYGESY-------------DGLGSAF----------\n",
      "---AQRKEYV-------GDKPLHLTEFGWADDN-------------------------AS\n",
      "NWD-----------------A-GYANSVIQTANMGVKSALMWQLNGVWTND---------\n",
      "-------------------P----TGG-----TNGTYT----MWDA--------------\n",
      "-------LPLGLNPRKTFYIAGMLNRYIP-EHSKVLAVDTNGS-----------------\n",
      "----------------------------------------------------TDVRAAAF\n",
      "R--------DNDG---HYTVLVEAKA-GTEKEITLDFGST-A----VNNTIRKMVYKNDI\n",
      "L----------QEPNA---------ILPPVTATFPGGA-ML-TDSNVSDDYNVIIYTTQP\n",
      "AETQVKLDNVNPTVRSGDSITLG--AEVIDNI----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GSVTWSVV----GQNNGTINSTSGVYQAPQVTDETLIAVRATSTADPSAYGVVLV\n",
      "RVLPSSLAGKVEVPTFSLDRHVFPSSEVL-YLETATSGAQI---------RYTTDGSEPT\n",
      "AQS--------------------------SLYVRPIILNEGSLALYKAK----AFKTG--\n",
      "--MQPSGTVSSLY-QIGQISSSP-----------DGYKLCMVE-----------------\n",
      "------NGG--------------------------------------DCYFQGKAV----\n",
      "-----------------VAYGADGL------------------------FNYSIQEDGVA\n",
      "CTSAIL-GDPIPGVNKRCYVNPEIPDELPVVTFFNAGFEKPATTSARPGPLTN-------\n",
      "---GWVFDSRSGVQHNNG-------PFQAP------------------------------\n",
      "------------------------------------AAPQGVQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TGYLKTDGGVSGT-------------------------------\n",
      "------LSQSIHFKPG--------------TYQMSFEAAKRTSF----------------\n",
      "--------GGTQSFDVYFDDQVIGSYQPES-GSFETFRT-----DAFETTGGKHTIQFVA\n",
      "TTTQG-----DNTAFIDDVRIT------------LPLT------------PEDP--YISN\n",
      "SSFESPVVTHPTGVLSGITADWSFNDQSGILRNGSSMTSMNAPTGLQAAFVRSQNGVQGS\n",
      "IHQSVTFPAGSYVL----NLKAAAQTAEQPQPVQIQVGGQTVGTITPSSSTYQSFTTDWF\n",
      "TVADG----SHTITLTATGTGTHATFIDQITVEEVDVPDQA--VLQNNGFEHPAITSQNG\n",
      "---VAVGSGEAWS------FKNNAGRIRNGSVFG-ASD--------------APEGTQAA\n",
      "YLQT---------------------LNGKQGEFSQSLIFPAGSYVIQFQAAKR-------\n",
      "-----TSF-GGQQSFDVYLDDQSI------------------------------------\n",
      "--------------------------------------------------GSFTPGSG--\n",
      "-------SYTAYTSNPFQITK-----PG------------------KHQIRFVGT-----\n",
      "---------SGTGDNTAFIDDIVITPNP--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QNK55806.1_Paenibacillus_sp_PAMC21692_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK---------SNRLPF---------------------------------------\n",
      "----------------------------------------MLVACVALLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AS------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------FIVFESADKVL--ANSTVNITLKNNTKAF--\n",
      "EGTTLGMGGTVMPF-GYHSSWK----------VKDF-NDDDL-AVLMTQFKKTGSTVARL\n",
      "WLDGAWW--EPTNDNADPDVMLDSGFTW------NSIEMNSLYKYLQAFKDMNV-DVFVD\n",
      "VMVDDPRV-----------MYPWLTAEYASN---------TGPNTGMIPEYAEHIAAMVK\n",
      "HLVVTKGFTNVKYVSFSGEPNNF--FLTPP---------GVSK-------LTSYKDSMTA\n",
      "VRSRLQSE-NLL--QYVKLIGPEIGYSDH-------------------------------\n",
      "------------DTASWLDDLST-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NISA-SLDA-----YTIHSGQTKA-------------EATDGSY---------V\n",
      "SLIKSFIDIIKTNDPNGADKPIMITDYTPTGTI---------------------------\n",
      "--------RRAE-------DGLNSVALIANGLRAGVSEFGRWSFADDIWTW---------\n",
      "-------------------P----AGSNQTSTSFGDYG-----FGIIGS-----------\n",
      "-------KQENFTPRPNYKATALAYKLIP-KGSTAYQATT-SN-----------------\n",
      "----------------------------------------------------EAVIPAII\n",
      "K--------TAEG---KHTIIVVNWS-NNDADVSFTLENA------IHTTFKKYKFESAS\n",
      "ID--------LVDKFG---------EIPASFGTKSISGTAF--TDTI-PANTIYYYSDIP\n",
      "DQTAP--------------------AQVAGLNVTAP------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-DFHKANLSWTAGAEADLSYYRVYRSETSAFTPAQANKVGEIWIKPGGVPSFHDRAVEQ-\n",
      "---GKTYYYKVSAVDSSENEGAASAYASV-QVGAEAYSDTLSVIDSTDYDYYEIDSDFAN\n",
      "GYKVRVYKKAGVIGFLQDKQGFSRQNLGLDFYSTPMVLKYNGS----------AFTDK--\n",
      "--VQNGGAESG--------STAP----------DNWYTW---------------------\n",
      "---NNANGS--------------------------------FTWD-ASVKHSGNRSLK--\n",
      "--------------ITNANQSANSTW-------------------------YQQTTD---\n",
      "-----F-----------------IPGKHYEVSYWIKTDQVDGPNGAGRGAYLNIQ---FL\n",
      "DANGVSLGARGGADAYSNVGTQDWTYFVSD------------------------------\n",
      "-----------------------------------VTVPIGTATVQIGANFYENSGTVWF\n",
      "DDIRFEEQPDVSIVGQHGMFYEADSVTYSDISST-----------HKRIVTVVGDETLYY\n",
      "DFYTDRIEIKVQGPNAGGYLIEDGGIVPRNVTSAYWSDGSEDVMSDTFPGAFVTKNTTSL\n",
      "GLYQPPSSQMIRYEFGSAKSVTLKNGGRFRGYYPRFQINSNEVFTMKF-PRKT-------\n",
      "----DNPNGGAES----------GTTSPDHWTTWNQSSSGTFAWDSGTRHWGNKSLKITN\n",
      "ATTDHS-------AWIAQMNAPGN---------LAKTLQLSAWI-----------KTLSV\n",
      "AGTQGAFIS-----------------------------------------VEAKD-----\n",
      "--------SAHNVL------------ATYRIPFVTG-------------------TNDWN\n",
      "KYQLSFNPPEGTAYLFIVGN----------------------------------------\n",
      "---LYSASGTAWFD-DFELSVADTGISNAGMEIGTGGPTGWS--------SWTSSGTPFA\n",
      "WDNSTYYKG----------------KKSLKITNNANQYSAWLTSRSNLQVSKEYEFGGWI\n",
      "KTSNVSSGAMGAQLQAIAMDSN--------------------------------------\n",
      "--------------------------------------------------GKWLQADVS-\n",
      "-------ATVLHGTNDWTYVR------GKI-----------TLPPLTASVQLQAQLWGVN\n",
      "G--------------TAWFDDLFIRLVDKS------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QNK57010.1_Paenibacillus_sp_PAMC21692_B\n",
      "MTK---------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "GEQMMDKGV--KTV-VKTICLLGLT-----------------------------------\n",
      "----------------------------------------AVLLLQTLLL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----------------------------SPTPLQANP----AAHTVSI---QPNVIV--\n",
      "QDDFLGVGVNVIPV-SFMEGTS----------QYGY-QEAHW-EMDKKRILALQPKVARV\n",
      "WFQIDWM--EPTKGN----------YTW------NSPKMLTFYKYMDALKEAGT-EIEFN\n",
      "FGWKVGAD-----------IQSWFSIPGV-----DA----KISAPADLDAYAASTSAVLN\n",
      "ELINNRGYTNIKYLTFYNEPNGN--WDFES--------PG-DQ-------QAYYATMVQK\n",
      "ASDRLTAD-GLR--DLVDIWGPEET-----------------------------------\n",
      "------------VA-SWTQYMSA-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NADA-YFDA-----YSFHVYSQTY-------------DGLSASI----------\n",
      "---ASRTNHA-------GGKPVMMTEFGFAQDD-------------------------MS\n",
      "GWD-----------------G-GLANSVIKAANEGVSAALVWQLNGVWLPD---------\n",
      "-------------------PY--VGSD-----TNGNYA----LWDS--------------\n",
      "-------LVVGTKPYKRYYETSLLTRYIP-AHSSVVSVNT-GS-----------------\n",
      "----------------------------------------------------PDIRAAVF\n",
      "K--------TSGG---DYTIVLETKE-GTSKDVTFDFNGV-N----IGKTFYKHVYRDDV\n",
      "T----------LEGNA---------IIPAASASFAAGA-TF-TDTGIDSEHNVVVYTTIP\n",
      "SQTQVEITPLEPMVTGGQSQQLS--ANVIDNT----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GGVTWSVI----GSGNGSI-TGGGLYTAPQVAAERLIAVKATSTNDPSSYGIALV\n",
      "KVRPAPSTGKVDIPTFSLAYGKYPSAEAV-TITTTTPGATI---------RYTTNGSTPT\n",
      "SSS--------------------------AVYTGPIFLNPGMTRL-KAV----AFKTG--\n",
      "--LTSSAEAYNLY-RIADASGGP-----------DGYQFCAYE-----------------\n",
      "------NGF--------------------------------------DCSFSGTAS----\n",
      "-----------------VAYGADGL------------------------FHYETLTNGTP\n",
      "CTNAVF-GNPNPGAAKRCYFSFDIPAEPPVVTIYNAGFEKPGTSTYLTGPITN-------\n",
      "---GWKFNVRSGVQRNGS-------ALGAA------------------------------\n",
      "------------------------------------TAPEGVQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAFMISRDGLSGE-------------------------------\n",
      "------MSQSLNFNAG--------------TYNLSFQLAERTSY----------------\n",
      "--------GGKLPFDVYVDNTKIGSFTPST-ANFTTSTT-----DSFTVTAGYHTIKFVG\n",
      "AVTSS-----EASAFIDAVTIQLA----------EPTN------------PPAA--ELIN\n",
      "DGFETPSVA---------------------------------------------------\n",
      "--------------------------SYLKGPMT--------------------------\n",
      "------------------------------------------------------------\n",
      "---------HGWT------FNSRAGVQKNGGAFG-AAP--------------APEGVQTA\n",
      "FLQS---------------------VNGNHGEISQTASFAAGTYNISFKAAKR-------\n",
      "-----TNS-GGTQSFDVFFDQTLI------------------------------------\n",
      "--------------------------------------------------GSYMPTSG--\n",
      "-------NFTAYTTDNFAASA------G------------------NHTITFIGT-----\n",
      "---------SSTGDNTSFIDEVKIQLVQPQNPPSLVIANDGFETPSVASYLKGPM-----\n",
      "-----------THGWTFNSRAGVQKNGGAFGA-------DPAPEGVQTAF----------\n",
      "--LQSVNG-----------DHGEIS-----------------------------------\n",
      "------------------------QIVDFEAGTYTLSFQAAKRTNSG---GTQSFNVY--\n",
      "------------------------------------------------------------\n",
      "----------FDQTLIGSYMPTSGSFSSYTTNSFAASAGYHTIKFVGTSVS---------\n",
      "-------------GDNTAFIDSVAVQ----------------------------------\n",
      "------------\n",
      ">QNK57015.1_Paenibacillus_sp_PAMC21692_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK--I------IKKYGMLLLA-----------------------------------\n",
      "----------------------------------------AAVMFQTLLF----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------SPEPAAANASP----ESFTVDI---DLQTII--\n",
      "NDDFLGVGANIIPV-SFMEGTN----------RFGY-NEAHW-EMDRKRILAMKPRVARV\n",
      "WFQTDWM--ELEKGV----------YQW------DSDKMIEFYRYMDVLQEAGT-EIEFN\n",
      "FGWKVGVE-----------AQEWFSFPDV-----DK----RISAPVDLDAFANAASAALN\n",
      "QLINVKGYDHIKYLTFYNEANGN--WDFEA--------PG-DQ-------KAYFAQMVKK\n",
      "VSDKLTAD-GLR--DLVDIWGPEES-----------------------------------\n",
      "------------GAPDWTQYMQE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NADE-YFDA-----YTFHVYGQSY-------------DGLTKSI----------\n",
      "---TDRTSVA-------GGKPVMMTEFGFAEDN--------------------------S\n",
      "AWN-----------------A-GLAGSVIKAANMGLGGALIWQLNGVWLPN---------\n",
      "-------------------PY--VGND-----TNGNYT----MWDS--------------\n",
      "-------LVLGTDPYRRYYESSLLTRYIP-PHSSVVAVDT-GS-----------------\n",
      "----------------------------------------------------EDIRAAVF\n",
      "K--------TDDG---EMTIVLETKE-GTNKEVAFDFNEA------VNKSFNKHVYRADV\n",
      "S----------IDGNA---------LIPGVSHTFAAGD-SF-ADDEINAEHNVIVYTTMS\n",
      "AQTQVEVTPLESTVEGGETQTFD--ANVIDNS----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----SGVTWSVI----GEGNGTI-TNDGLYTAPSVTEEKLIALKATSIQDDEGYGIALV\n",
      "KVRPTAAEGQATIPAFSLPYGKYPSGEAV-TITTATPDAEI---------RYTLDGSTPT\n",
      "LAS--------------------------ELYTKPIFLLRGTTPL-KAV----AFKDG--\n",
      "--MNPSPVSFSLY-KMANASLGP-----------DGYQFCAYE-----------------\n",
      "------NGF--------------------------------------DCEFTGEAS----\n",
      "-----------------VAFGSDGL------------------------FHYANLTDGAA\n",
      "CTSALF-GDPNPGTEKRCYFTYNIPAELPVVTVYNAGFEKPNVANYQTGPMTN-------\n",
      "---GWYFNVRAGIQRNGG-------QFGAA------------------------------\n",
      "------------------------------------RAPEGGQ-----------------\n",
      "------------------------------------------------------------\n",
      "----------------TAFMVGRSFIGGE-------------------------------\n",
      "------ISQKLHFKEG--------------DYELWFSMASRSTP----------------\n",
      "--------GGELPFDIYFDDTLIGSFEPNS-SDFTLHKT-----DSFTAAAGYHTIKFVG\n",
      "AATET-----DHAVFLDGIKVRTAGMAPPPPDVQEPLP------------PEKPLETLGN\n",
      "AGFEEPQVA---------------------------------------------------\n",
      "--------------------------THRAGPMK--------------------------\n",
      "------------------------------------------------------------\n",
      "---------FSWN------FNLLSGVQRNGGAFA-AAT--------------APEGIQTA\n",
      "FLQT---------------------KGGQFGEISQYLNFEEGRYKLEFSAAKRS------\n",
      "-----TNG-GRTQSFDVYFDDTII------------------------------------\n",
      "--------------------------------------------------GSYSLTSP--\n",
      "-------DFESLSTISFNASE------G------------------PHTIKFVAT--HTS\n",
      "G-------QSETGESTGFIDEVSLRDVSGEPPD----PEEPAEEP--VALLEGPSE----\n",
      "----------VHAGDTLDLKIGISKANEGYSAMDVIVHYDPAKLEFETIVDDDGHLILSS\n",
      "NAIQSLVGQLQVIGTGVKPEQGQIRILMLGTGAPVSEDGHVIALQGKAKASASAGSTIIT\n",
      "LSDFGISNESAAWQVDSHEAMLTVQVIEVDKSALNAEIVAAQALHDGATEGSHS-GQYPV\n",
      "GSKNVLHAAILAAKAVNENSNATKQQVMEAVSTLQQAVMMFRNSVHVAVPADKTALIAAI\n",
      "DNAQSKHDAAVDDGKLGHYAP--GSKASLQTAIDAAKAVRESTSVTQTNVNDAVSGLNDA\n",
      "VQHFASQLVTLVEGNSRISIADLSIVAKYYGINSENASWNEIAIADLLDEGEITIRTLAA\n",
      "VARMILDDWLAE\n",
      ">WMJ22082.1_Paludicola_sp_MB14C6_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------SKIT------ARKEPI--\n",
      "MARFCGAGFHNSEA----------------GLYRKM-SDRQFNEVVGKIYRELSPGFTRM\n",
      "WGGA---------------------PNW------TKEEMDDF---AEYCEKTHI-PANTS\n",
      "I-YLTGHTT-------------------------------RHQTQQEKEEYARNVADKLD\n",
      "YLINEKGIKNIEFYCMSNELSIED-WGNIF----------FE--------LPVFKDYHTY\n",
      "LYREFKRR-NLP----VKLLATDASPYERW------------------------------\n",
      "------------ESIDWA-ISN--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GMVP-ISEI-----FGGHHYVNDF-------------EPQDLDF--Y------K\n",
      "VFYKNVKKTVKKLLP--YERRFILGEFGLAQDM-------------------------NN\n",
      "VNGVKMDVCKYFYDGQEAYSALMITEMALAAINAGVYACALWTFTDYPNPK---------\n",
      "----------------------------GTDFRYNKWGL--TKW----------------\n",
      "-------DGDDYSPRDWLYCYGLIAKYFN-KDSKPLTIET-ED-----------------\n",
      "----------------------------------------------------YYLRCGGV\n",
      "S--------NDDG---SFSIAIVNRH-EESTDITVSLKAL-S----TNQPMRKYVYDSAN\n",
      "V---------PRNKFG--------DMQSYTELISVTEDTAC---IQV-PANSVTLLTTDY\n",
      "INRTP--------------------CTVEDVSEDN-------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----GMIRWSKS------------------T----------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------DPY-FCYYR-----------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------------IY-------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------KGDSQNFVPSYDNQIASTIVESY--------------RDESGVAGFYKVKVV-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------------------------------DRF------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------GNV------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">UVQ47681.1_Parabacteroides_faecis_B\n",
      "MRKKIFYFVVA----LIIYPYICIGQTIASMDSRATDVEHWISSHFAQGTVPPFSFEYGG\n",
      "KPSKEFIKDWAYSAKPLKSDDQHEVRYCYTYQDPASGLKVDCDVKGFTDSQAVEWVLHFT\n",
      "NTGSGNTPEIANVCVSDIVFRYDRPGNFRLHYANGSFP----SKADFAPRLKELTSGE--\n",
      "-NLYMRPDG-GRSS-HTAFPFFNIESPSGQGVMVAIGWTGTWFSDVRCTDVQSI-----Q\n",
      "LKSGIERLKAY-------------------------LYPKETIRTSSVCL-----LFWQG\n",
      "NDRMIGHNQFRRFILAHHT--RKVDGKP--AQYPFCK--GFNYGDPTPCNEYTCLTADYA\n",
      "IALVKRYKQFKL-LPEVFWLDAGWYDQSADVANNKNWANTVGNWTVDSVRFPEGLKPIAD\n",
      "EIHKVGSKFMVWFEPERVYYGSAWAIEHPE-YMLE-RPGA-----------DACLVNLGN\n",
      "PKACRWMSEYIGDFIEENNIDYYRQDF-----NIEPAGFWEANDEPGRQ-GICEIKYIEG\n",
      "LYAFWDYLLERFPNLLIDNCASGGRRL---------------------------------\n",
      "---------DLET--------TTRSAPLWRTDYSYGEPDGYQ-CHTYGLNFYLPLHGTGA\n",
      "WGVDKYTCRSSLSSA---VTFNWKITEAGVSIYDMRDRQAEFEELRPYFLEDYYPLSGID\n",
      "NTTAENT------WLAYQLYRKSDDSGYIVAFRRKECPDKDCRVELFGVNPDKTYLLINK\n",
      "DTGDSIRKTGKELSEGLTLTLD--EPRSSMIIRYQSDL----SESVHDL---VVGEKT--\n",
      "DAVLQAIGAEFDPH-FLSQNVT---------RNDGA-KEKDWKNIIEKRIKDMDIHRFRV\n",
      "MVLPQWY--EPENDNDDPDLINWDKFTF------NSPEMQSLYRELDLAQQQQM-EVTLT\n",
      "L-WGAP-------------DKHFLAGRNSGD---------WVVAPESNEEWSENFSALIQ\n",
      "YLIKEKKYTCIKEITPVNEPDWS--FLVNGK----------------RASTAKYIEMCKA\n",
      "LDRRFKKD-GIR--ELVDFSLSDNSDGGI-------------------------------\n",
      "------------GTHKYLAACTR-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------ELAD-VADV-----FNSHTYIFGY-------------ETPNSTI---------L\n",
      "DWERQNYELSR-----SAGKPHFVGEFGGNQCVG--------------------------\n",
      "-AARQKDINLYE-------RGVLMVRIAINLLNAGASGVSYWSLIDQYYGK---------\n",
      "---------------------------NDSYEGMQQLG----LWKYVKNAYAQDT-----\n",
      "---CYENMTVDYEVRPQYFAYSLLTRFIR-PGAEVYPIST-PN-----------------\n",
      "----------------------------------------------------EFYAGTAI\n",
      "K--------NKDG---KWVYIFANGT-AQEKKIKISNKHV-G----AKGTYEVYKYTQNA\n",
      "L---------PKGDKQ---------ISPEKQVMKGGNE----FFYTL-PTNSVILLREK-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">BDD02170.1_Persicobacter_psychrovividus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MN------------------------------------------------------\n",
      "----------------------------------------LLALMVAGGL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------A-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------F--GG------------------\n",
      "-------------------CNNETDL----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------P---------\n",
      "-------------------------------------N----PAANLSM----NSKVV--\n",
      "STDFIGNGAQWGGY-EMASKWL--------NGQESL-SEADW-ATLFKRIDFMRPPFLRI\n",
      "MFNSGGIA---------P-------ADY------SSAKTKSLFKMLEYAQSRNI-EVVFG\n",
      "E-WGYAHK-------------------GADL-------------LDVDQEWVSNSVQFLD\n",
      "YLIEKKGFSCIKTTNIINEPNGD--WSAAR---------S-R--------YDVWLKVQQQ\n",
      "YIQAMKKF-PAL--QAVQLTGPDIAVFKD-------------------------------\n",
      "-----------AAAKDWIQRASN-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------DIGK-NIGM-----YDIHAYVGQQ-------------FVKSGQY---------G\n",
      "QMLHEFKEATP------AGKKLVLTELGFKYIS--Q-EDVDLKNENIKAIENDKF---AG\n",
      "-DDSNMMVYKPF-------YGVDMADAIIQGMRQGVSGTLVWSMDDAMYNS---------\n",
      "-------------------P----KGNDYNTPELKKWG----FWNILGEEHCN-------\n",
      "-------DAKDEAIRPFFYPVSLLCRYFP-AGSTIYTLDL-GA-----------------\n",
      "--------------------------------------------------K-KGLRAVMA\n",
      "E---------KDG---KYTIAMVNGH-YATYELNLLNKKL------GGQDMDVYRYQAKF\n",
      "DG--SDTFDAPTDKDG--------FAVPTETNRHFQFNENT--PFEI-KGQSVVLLTNMK\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">BDD02164.1_Persicobacter_psychrovividus_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---MLN----------KY------------------------------------------\n",
      "----------------------------------------FFGAGLLLAL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------QA------------------\n",
      "-------------------CNQAPQH----------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------PTVTV---HKEQVV--\n",
      "CNQYIGNGVEWDAY-PHADSKSA-------EWGDLMNNPAKW-DTLYARLDRMQPQFIRM\n",
      "MDQANWRYYMGLNRHKKAV------LNF------NTPEIKTLFKLLDYCQSRNI-TVVMG\n",
      "E-WGTPHHMH--------DIE---NKKDKLK-------------AADDPRWSKMIAQYLD\n",
      "FLINKKGYSCIKYYNLVNEPNGD--WASTL---------G-D--------FDLWKRGVKQ\n",
      "LHKELKAK-GLD--DKIQISGPGTVPQYSYP-----------------------------\n",
      "------KYKSQYEGKDWVKMSVD-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------SLND-ELGA-----YEIHAYMPTM-------------IVREGKA---------A\n",
      "KDVFWKEAIAQ---THKTGKPFLIGELGLKDNF------GPFHEKNIARAKKDAF---TS\n",
      "PEDSQMAIYDYQ-------YGVDMADAVVQFMNAGCAGTIAWALDDAMHTM---------\n",
      "-------------------------GDKGDKTKLKRWG----FWNILGTEIEN-------\n",
      "-------SPKDEQIRPWFYPWSWACKYFP-AHTEILKVDV-PA-----------------\n",
      "--------------------------------------------------I-KGLRITAG\n",
      "T---------KED---KYSVMAVNNS-EEIQTVTVQIDGL-K----SSPQLKKLTYTREQ\n",
      "A---------TAEKAK-----------ISTEQVSVSAQGGL--SVTL-PAKSVVVMTNMN\n",
      "K-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">AGB28643.1_Prevotella_dentalis_DSM_3688_B\n",
      "M-----------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--IMMK------------------------------------------------------\n",
      "------RF-----------------------------YIGLIIFLSATPI----------\n",
      "------------FAQTQIVVRQKSGGM---KAIPITSISNITFGE---------------\n",
      "----ERLKSIDLGLP------------SGTLWSNCNLGST----------YPEEY-----\n",
      "------GDFFAWGEP--IQKAS--------------------------------------\n",
      "-------------FTQQNYLYYSNGTYTAIGNNISSTSHDAATENLGGQWAIPTIQQLQE\n",
      "L---------------IDHCT---------------------------------------\n",
      "----------------------------W-TWNSYNNIPGYTVTGTNGNCIFLPANG---\n",
      "---------------------------------------------------NYY-----D\n",
      "GTTHDNIGTCGFYWSAN-----------------------------SGTQARNARFLGFK\n",
      "KGEYTIQENTRDLGF--------------CIRPVTHQP----ENQPLQL---SVGNPT--\n",
      "GVSLQGIGVEFDPH-FLTACLA---------KNDGA-KTEDWDNVIVPRVKQMKPHNFRV\n",
      "WVMSQWF--EPTNDNDDPYTIDWNTLNF------NTKEMRALCKELDLAQEINA-EVTIV\n",
      "F-WGAS-------------VGSWMAGGQTGN---------WLFVPKDYDEWAENCAILAK\n",
      "YLIDTKHYTCVKMLTPINEPNFY--YGHFQ-----------------YMTAANYSIICHK\n",
      "IADQLDRL-GIK--DKISLNLSDNIH----------------------------------\n",
      "------------DDIDFLAKACE-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NVKD-VAGM-----FNSHCYRFGY-------------ESSNEEI---------G\n",
      "AWEKRNVDLAK-----AAGKMHFVGEFGSNRTML--------------------------\n",
      "-SARQADIDYYR-------RGILIDRLVLNFLNYGACGCSYWQLFDEWYSA---------\n",
      "---------------------------HDSYASMQQLG----MWRYVKDVYRNEP-----\n",
      "---YYYKLKYDYQPRPQYYAYGLLTQHTR-PGADIHPISI-NQ-----------------\n",
      "----------------------------------------------------GKMAATAF\n",
      "R--------NVDG---RWVYVFANPD-NTSYTIDLTNKYH-N----QSNKFSVFRYMADE\n",
      "L---------PYDDKL---------LAPVDEVEAGNH-----LYCKI-PATSVVLIKEK-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">AGB28629.1_Prevotella_dentalis_DSM_3688_B\n",
      "MKTIRLYRFLAC-CFCLVMPFLLKAQTAIDFRGERMDVGRWAATHFARHGEHPFSFTYGG\n",
      "RASATFLKGWSYTVSRRMSPLSDVTNTVYTYTAPDRSLRVDCDVKLYRRQQAVMWTLRFT\n",
      "NIGQRPSQPIAQVKTTDLSLQNRGRQPFTVHYAKGSNA----DPDDFAPRQTVLSGDA--\n",
      "-GLSLRPVG-GRSS-QGNFPFFNLDTGRGQGVIAAIGWTGTWMADFRSTAPGCM-----S\n",
      "MVTGIERLNTW-------------------------LKPGESIRSSSACL-----LFWQG\n",
      "ENHVDGQNQWRRFVLSCLT--PRVDGRP--VCYPLTT--SFNYGDPYPCNEYTCLDEDYA\n",
      "IALVQRYKQFNL-APKVFWLDAGWYAESARVKEGCNWYNTVGNWTVDRDRFPNGLKPVSD\n",
      "AVHAIGSELMVWFEPERIFKGSQWSKELPKAWLIDGGPQT-----------ESYLFNLCD\n",
      "TAAVAWLSRYINRFMDENGIDHYRQDY-----NIEPAGFWAANDEPGRE-GVTENHYVEG\n",
      "LYAYWDNILKHHPHGFIDNCAGGGRRL---------------------------------\n",
      "---------DLET--------IQRSAPLWRTDYRYGEPVGYQ-THTFGLALWLPQTGTGV\n",
      "MGSDKFSSRSSLSTT---VVYDWKITEPEFNLTEVRQLMDEYEELRPYYFEDYYPLTGTD\n",
      "RVLGDSI------WLAYELNRPSGQDGVVVAFRRASVPDSSCTVRLRGLDPRLTYTLTDR\n",
      "DSRRSFTQTGAQLARGLRLVLP--QPRSSLILTYTANP----AARPAQL---AVADPN--\n",
      "PQKVVGMGVEFDPH-FLSQNVT---------RSEGC-RAEDWDSVICRRVAEMQVQRFRV\n",
      "MVLPSWY--EPQNDDADAHHIRAAGFTW------ESREMQSLYAELDLAQRLGI-QVNLT\n",
      "V-WGAE-------------RNHFLAQGNDGD---------WVVAPTNLEEWAENISALVQ\n",
      "HLLHDRHYSCIREITPVNEPDWA--FIHNGR----------------KSTPDPYIRMCRV\n",
      "LDARFRQD-GIR--DKVDFCLADNSDGGM-------------------------------\n",
      "------------GTHKYLQACTR-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GLAD-VADG-----FNSHTYIFGY-------------DTPNSVI---------Y\n",
      "HWEWENCQLAG-----RAGKPHFVGEFGGNQCVG--------------------------\n",
      "-STRQRDINLYE-------RGVLLARIAINCLQAGASGLSYWSLLDQYYGR---------\n",
      "---------------------------QSDYNAMQQLG----LWKSVWRAYAGDS-----\n",
      "---LYQGLHTDYEVRPQYYAYSLLTRFVR-SGAEVYPIPT-ND-----------------\n",
      "----------------------------------------------------EFYAGMAL\n",
      "K--------NTDG---RWTYVFANAH-ATPRHIRLSNRRA------PKGTFEVYRYVQQE\n",
      "L---------PTDGRQ---------IQAAAQRLRGQTE----LDYVL-PASSVVVFYQTT\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-----F------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QMW75430.1_Thomasclavelia_ramosa_DSM_1402_B\n",
      "MVHRVKQVSIVVLSMLVLLSTLIVG-----------------------------------\n",
      "-----------------------------TYA-------------------------KAT\n",
      "NL----------VSNGDFS---QGTNYWSMNQSDGSLAMMSSDNHSLKVQIEKVNSDDYW\n",
      "WSLTLKQDNIALSA-NKKYQLSFDVEASMSGDISL---------DIESTSDYNKKYLDRQ\n",
      "MIAISNQKKTYTFDFEKKDDDAVTLVYHLAKGDGISDFSNQIIKLSNVTI------IEIG\n",
      "DIEIQKAGDW--YLNEGDGANGKLSGEPNDLKVKVTSINQENY-----------------\n",
      "-----------------------WW--ALSL-------------------KKENLVLSGN\n",
      "KIYKI------------VFDAK--------------------------------------\n",
      "----------------------------------------ASKA--GTI-GI-------D\n",
      "IEKSADYNVKYLDKQNFDLTTTSKEYSFNFIKKDNDDVSIVFLLNEGDGISNFKDETINI\n",
      "RNVRIEEVNDLGDEYVVNGDFETNTTSGWNTYNSNGSNLKINAVNQQLEVTFPNSNGSNY\n",
      "WDCQLFQGDILLDNGIYRLSYDLKGSKAGTIYFDVEDTGD--------YATKYYPETMVD\n",
      "FTKDVQTYNFEFEINADNL-----------------LGTQKNAKIQFNLGPN--------\n",
      "-------EHCDSLAGE-TLYFDNIKIEKIGSGAGTGEL----QTTNVTF---DGNDVL--\n",
      "VNNFKGLGVQWDPY-VV----------------HPL-TDEEW-QTVTKRVDFLNPAFVRC\n",
      "MIYANTYC-EGFDDEGNPI------YDF------DSLANQALIRELDYLESRDI-EVVLG\n",
      "E-WETPGR-------------------FGGE---------FEGITVDDPRWASIIGGFLD\n",
      "YLINQKGYTCIKYFNYVNEANSD--WSYCG-----------D--------FDKWQTGINY\n",
      "LHTELDKY-GLN--EKIKITGPDTVWD---------------------------------\n",
      "------------SDNTWLKEINSNQ-----------------------------------\n",
      "------------------------------------------------------------\n",
      "------DLGA-KIGL-----YDTHMYPTID-------------EITNGTI---------E\n",
      "EMVAEQRSCV-------TGKDFYMTEIGMVTGK-------------------------SD\n",
      "-GDSQPYTKEFS-------YGVIMADAASQVMRGGFSGLAIWDLDDAMHDQQ--------\n",
      "-------------------N----GFPITDIRSLKQWG----FWNSVAGRVFN-------\n",
      "-------QPEEEEIRPFFYTWSLMANLFP-RNSKIIGSTA-NKE----------------\n",
      "--------------------------------------------------L-NGLRTVGM\n",
      "E---------KDG---QMTYMIVNDS-NSPKEVTIDVKNLNA----NNLKLFKYDYFDND\n",
      "R---------KVDSNG--------YPVASKVLENVNLEEGY--EVSL-PSGGVVMLSTID\n",
      "IEDAK--------------------KELVDQNDSKQ------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------DNE-----------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------NKNEVAIKTG--------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------DDLKAAGFMI----------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------SGLLATAFI--------------------------\n",
      "------------------------------------------------------------\n",
      "---------YGMK-----------------------------------------------\n",
      "---------------------------------------------------KK-------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "---------------------------G--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">QQV06122.1_Thomasclavelia_ramosa_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MR----------EKYKGERNIM----------------------------------\n",
      "-----NRK-----------------------------FKRFLTSLLSLAV----------\n",
      "------------------------------------------------------------\n",
      "------------------------------V-----------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------AS------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------------SGIGP---------\n",
      "-----------------------------VKAVDNTPK----LDSKVYI---NSDNVL--\n",
      "TKDFEGFGVQWDPS-DL----------------FDY-TDEQW-SSFYEKASFLSPNVMRV\n",
      "MLHDGDSYCIGFEDDGTPI------YDW------ESVMMKRVYKILDFAQQNDI-PIMLG\n",
      "E-WRSISE-------------------RGYLSY-DD---HGKTVNWSSPTWARMIGDCLE\n",
      "HLIVDKGYTCIKYYNMINEPNY---YKRDH---------G-DVT--NEYVYDQWKQAITN\n",
      "LRNEMDSS-GIEKIENIKIVGPDVYD----------------------------------\n",
      "------------SQEAWINQATSD------------------------------------\n",
      "------------------------------------------------------------\n",
      "------EMKD-KIEL-----TEVHRYAPQS-------------EVESGLI---------E\n",
      "KKLKTWKEQAESLDPEVAEEGFALGEMGISG---------------------------TG\n",
      "PGDSQLNARKYD-------YGVDIFDYGVQAIRAGLKFGSVWGFEDSMHVQHNDIVNNFK\n",
      "DQYGPAATTEEGRDYVVHTP----TGDPSIDNDIKIWG----FWNELGEEMAAQNAEHNV\n",
      "TGRANTVKASDENLKPWYYTWSMLCRYFP-SGTKILETTD-SY-----------------\n",
      "--------------------------------------------------V-DQLRVTSG\n",
      "IIPV----ADDKG---DISIAVVNNS-SSQKTLEVNMPNA-A----SKVDLNQYFYYDGE\n",
      "IDGKTR----PVNEKG--------QLLQYDTIENANLKDGV--NVTL-PAKSCMILTSLG\n",
      "YEGES----HPMSFTTGQTTDVE-KVEIYETTNANQLEVG---KSYQLA-----------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------------ANYI\n",
      "PSISKGEMEWSVVDYFGNASDKALIDENGLLTVKKAGQFKVIGNLKGKPE------IQDT\n",
      "LVFKATSSSILVDELNDLENGVALSYQDI--------------IKDDNSANFNGDKTVKR\n",
      "SDSNA-NGKPGIITY----QANNIYDFEFSAYSLNNNLDKSGNFVVEVSQNGDSWSPVEC\n",
      "EFIQGSKLSSGWY---------PYTIKNKAEIKDDGYQYLRVTITSKSGYKTYDPQYAGG\n",
      "SIYYDYQGASQIDIQSHNEFIVKGQELQFKAEVLPSIASQEVSWK--VLSLEGKPTELAT\n",
      "ISPDGILTAKAKGEVVVVATAKDTDVSAYSHINIINGYFVDEIEDFSKMYQYGEFA----\n",
      "-----F-DDPKSSNFTDKTRIKRLSDSNQSIVYALSDIEKATFEIYKNGSFVNDSVDIYA\n",
      "SSDGLTYNKVEKNVVNAGKAASSTEYYLYEVSTKELGDNVNYIKLELKNDEIIYCPMLGK\n",
      "TKIIYNPIENVEVTNVTLDQKELSINVGQSKTLVKKLAPLYADEQ-----------LTWS\n",
      "SR-----DEDIASVDQNGI------VTAKKVGSTIIYAKYNDEIYATSVINVLGENMALN\n",
      "KDVSASTETNQWNKNPTGKLVNDGDY-DTR-----W------VSKD--------------\n",
      "--GTSITKEQITIDLGEVTTVD--------NVKLYWESARATDF----------------\n",
      "------------NIEVSTDGSKYDIVEKLRDEDKNKLTN---------------EISFDP\n",
      "VEARY-------------VRMQGL----------TPATKYGYSIYEFEIYNNSDLKLASS\n",
      "VEFKEMSSELYLG----------EN-----------------------------------\n",
      "--------TALDVVVTPDDATYQDASYTSSNEFVVV-------------------CKNNQ\n",
      "MIAVG----EGTATITANVNGQKIT--KEITV----VKDNARKIAQ----ELTSLTVENG\n",
      "RVDFPTVDGYSFS---VFSSDLEKVIAKDGSVNLPVEDQEVALVV-TVSKDGSEDSANTD\n",
      "EIKV-----MVKGSRDKYELLEKRIKEIEETDWTVYKPGTVKTFKEKLQAVKESLNAGVL\n",
      "L---VSEVEKAGENLEAAFKGLEIKSDKKTLDALIKELEELDTKVYTEVSVARVEKALEK\n",
      "AETVSENEDASEAEVNDAVQALYEAKLGLVEQINYDNLKDRIEEIEKEDLSIYSEATAAR\n",
      "LKEQIAEAKEALKNENITNEELQEELAG--------------LNEKYSSLKLNHEPGSVE\n",
      "ELIKRIEEMDLSGYSEASVKELERVIKEIK-----------------EELLEGVDQ-V-R\n",
      "YAKLAEKLQTAYEGLERKSEV------------------KP-------------------\n",
      "----------------VEPEQ---------------------------------------\n",
      "-------------------------------------LETPKGDEQAAKTG---------\n",
      "------------------------------------------------------------\n",
      "-----------DNMIIGTWL---------------------------ITMSAAV------\n",
      "------MVVIFLNKRRS-------------------------------------------\n",
      "---------LEK\n",
      ">ADB80105.1_uncultured_microorganism_U\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------TC------------------------------------------\n",
      "----------------------------------------PLLLLSAFSL----------\n",
      "------------------------------------------------------------\n",
      "------------------------------A-----------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------WL--A------------------\n",
      "-------------------TAC--------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "-------------------------------------E----KRIELTI----TDEVI--\n",
      "NAHYLGNGVEWDPY-DEAIS-----------WGCPL-SETEW-DTLYARLDYMQPQYVRC\n",
      "MINSPFTYFTGE--GFE-----------------DGRNAENLLKLLSYCQSRDV-MVVYG\n",
      "E-YNPPTWE-----------------------------------MKGSQEWVEASVKHLN\n",
      "WLVADQGFDCIKHFVIFNEPDGN--WASTD---------G-D--------FGFWREMVRR\n",
      "FQAEMDKYPVLK--EKVSIAGPDAVIDYR-------------------------------\n",
      "------NPASPYDAAGWLKAT-V-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------EGVP-EIGI-----YDMHAYPGQR-------------YVRSGEF---------E\n",
      "ETLKGLKALV--------DKPIILGEAGFKYFS--DPADSALAQEYWKRVEGHPF---TK\n",
      "GSDCNMLVYDSF-------YALDMPLLLMSVMNAGFSGAAAWMLDDAMHSN---------\n",
      "-------------------------GDSGKTEDVKLWG----MWNILGDKVFG-------\n",
      "-------DASQEEVRPWYYTWSLMCRHFP-AGSRILRLQG-LP-----------------\n",
      "--------------------------------------------------E-GMAAAVAQ\n",
      "K---------PDG---TYAVALVNFG-DQAQEVRLQLPE-------TCDGYSVQYYTDHL\n",
      "E---------KQS-------------VPASRKPAL----------TI-PAQAFAIFA-IE\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">CAZ94303.1_Zobellia_galactanivorans_B\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----MK----------KM------------------------------------------\n",
      "----------------------------------------ILYNLFLLLI----------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "----------------------------------------LA------------------\n",
      "-------------------CSSESSTDT--------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "--------------------------------------------------PP--------\n",
      "-----------------------------ADKDLSTEK----PGETLLI---KNQNPL--\n",
      "SVDFVGNGAQWGGY-ELIENFT---------GVDDF-NEADW-NTLKERIDFMRPSFMRI\n",
      "MVSSGWNY-TDTDGAFQP-----------------EKGNNAFHRMMQYCTDNQI-TVMFG\n",
      "E-WGHSYL-------------------NDDR-------------NQVDETWLDNAVNYLD\n",
      "YLIDTKGYSCIKYYNMVNEPNGD--WSSTN---------T-D--------YELWQKVASG\n",
      "FQSRLESK-GLH--QSVKLAGPDIAVFGD-------------------------------\n",
      "-----------AGAVSWITRSKS-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------KFNE-KLGL-----YDIHAYPTKS-------------FVTEGGY---------L\n",
      "EMLKAYKGAIP------EGEQIVLGEIGIKFYG----ADADLQTENLKRINADPY---AS\n",
      "-DDSNMSVYDGT-------YAIDISDAMVQSMMAGFSGALVWDVDDAMYNKS--------\n",
      "-------------------G----SGSGPDAKKLKRWG----FWNILGEEAFG-------\n",
      "-------GASDEEIRPFFYPVSLLCRYFP-KGADIYEVQL-PN-----------------\n",
      "--------------------------------------------------K-KGLRAIAA\n",
      "K---------KGD---TYTLAIVNSNFVAYDDLSIKAEDN-F----SFDGVSQYVCTSMP\n",
      "DG----SFQAKVDANG--------FALPLEQDISIPLDGKH--KVNI-PARSVIVLTNMP\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      ">CBK67650.1_Bacteroides_xylanisolvens_XB1A_B\n",
      "MKKRILYYLFI----LLLFPHNGTGQTVARMSDRPVNTSQWITTHFARGVVPPFSFEYGG\n",
      "KPSQEFIKSWSYTATRQKSDDPKVLKYLYTYREPSGGLKVECEVKGFTDFNTVEWVLRFT\n",
      "NQGKKNTPEIANIKVSDITFRYQHPGAFNLHHSEGSHA----SKSDFSQQLTILSPGD--\n",
      "-NLYMRPEG-GRSS-QMRMPFFNIESPANQGVIVAIGWTGTWFADVRCADQQSV-----A\n",
      "LTSGIERLKTY-------------------------LYPEESIRTSSVCL-----SFWNG\n",
      "SDRMKGHNQFRRFVQAHHT--WKVGGKP--TVYPIST--SFNYGDPTPCNEYTCLTTDYA\n",
      "IAMVKRYEQFKL-VPEVFWLDAGWYNHSADVANHKNWANTVGNWTVDSIRFPEGLRPIAD\n",
      "EVHRVGSKFMVWFEPERVMKGSAWALQHPQ-WMLDARGKAKQEDWTKDGEHDSYLFNLGN\n",
      "PEACRWMSKYIGDFLEENGIDYYRQDF-----NIEPEGFWAANDEPGRQ-GICEIRYIEG\n",
      "LYSFWEYLLNRFPGLLVDNCASGGRRI---------------------------------\n",
      "---------DLES--------ISRSAPMWRTDYSYGEPIGYQ-CHTYGLNLYLPLHGTGT\n",
      "VSADKFTFRSSLGTS---IIYNWKITEAGQSIYDMRDRQAEFKELRPYFYEDYYPLSGIN\n",
      "NITSENI------WLAYQLYRPSDDSGYIVAFRRKDNPDKSYTVNLSGLHPDHTYILTNK\n",
      "DTGEAIKKTGKELANGFTLTLD--NPQSSLIIKYQS-S----TTAIQKL---SVGKKT--\n",
      "GVKLRAIGAELDPH-FLSQNVT---------RNDGA-KAEDWDRIVVKRVKEMGLQSLRV\n",
      "MVMPQWY--EPKNDNPDASKIDWHNFTF------NSVEMQSLYKVLDMAQEQKM-EVTLV\n",
      "L-WGAP-------------PGHFLTEGNYGN---------WVVAPTNYEEWSENFSALVQ\n",
      "HLLNNKKYTCVKEITPINEPDWS--YIIKGK----------------AAPTADYIEMCKV\n",
      "LDRRFKED-GIR--NKVHFSLSDNSDGGT-------------------------------\n",
      "------------GTHKYLAACTK-------------------------------------\n",
      "------------------------------------------------------------\n",
      "------GLAN-VADV-----FNSHTYIFGY-------------ETPNSTI---------L\n",
      "DWEKQNSQLAS-----SVGKAHFIGEFGGNQCVG--------------------------\n",
      "-ATRQKDIDLYE-------RGVLMTRIAINLLNAGASGVSYWSLIDQYYGK---------\n",
      "---------------------------DADYGAMQQLG----LWKYVKKTYASEP-----\n",
      "---YYNDIKSDYEVRPQYYAYSLLTRFIR-PGAEIYPIAT-PE-----------------\n",
      "----------------------------------------------------EWYAGTAV\n",
      "R--------NTNG---KWVYVFANGM-DQEKAISLINQHT-Q----TKGNYQVYRYIKDG\n",
      "L---------PTTDQM---------LAPDAQPLKVNDK----ILCLL-PAHSVIVLKQE-\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------------------------------------------------------\n",
      "------------\n",
      "\n",
      "Finished!\n"
     ]
    }
   ],
   "source": [
    "#MAFFT\n",
    "import subprocess\n",
    "from subprocess import Popen, PIPE\n",
    "\n",
    "def MAFFT(execute = True):\n",
    "    \"\"\"When execute is True, this function runs the Clustal Omega executable to perform a MSA\"\"\"\n",
    "    if execute: \n",
    "        \n",
    "        #path to clustalo_exe\n",
    "        mafft = os.getcwd() + '/mafft' #r\"/Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/mafft\"\n",
    "        \n",
    "        #name of the input file\n",
    "        in_file = os.path.join(jobname, f\"CAZy_{jobname}_inclchar_selected.fasta\") #'/Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/CANDy/V1.0/GH57_All/GH57_MSA_Catdomains_75_cleaned_1.fasta' #s.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_inclchar_selected.fasta\")\n",
    "\n",
    "        #name you want to give to the outputfile\n",
    "        out_file = os.path.join(jobname, f\"CAZy_{jobname}_aligned.fasta\") #os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_aligned.fasta\")\n",
    "        \n",
    "        #perform the multiple sequence alignment using MAFFT\n",
    "        mafft_cmd = [\"mafft\", \"--auto\", in_file]\n",
    "        with open(out_file, \"w\") as outfile:\n",
    "            p = subprocess.Popen(mafft_cmd, stdout=outfile, stderr=subprocess.PIPE)\n",
    "            _, error_output = p.communicate()\n",
    "        if p.returncode != 0:\n",
    "            raise RuntimeError(\"An error occurred while running MAFFT:\\n{}\".format(error_output.decode()))\n",
    "    \n",
    "        with open(out_file, 'r') as r:\n",
    "            print(r.read())\n",
    "\n",
    "    print('Finished!')\n",
    "    return\n",
    "\n",
    "alignment = MAFFT(execute)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "af648417",
   "metadata": {},
   "source": [
    "# Phylogenetic tree: FastTree"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 80,
   "id": "5b2d773b",
   "metadata": {},
   "outputs": [],
   "source": [
    "from Bio import Phylo\n",
    "from Bio.Phylo.PhyloXML import Phylogeny\n",
    "from io import StringIO\n",
    "import matplotlib\n",
    "import matplotlib.pyplot as plt"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 81,
   "id": "0cfcbecd",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "GH173_clustering_test/CAZy_GH173_clustering_test_phyltree.nwk finished!\n"
     ]
    }
   ],
   "source": [
    "from subprocess import Popen, PIPE\n",
    "\n",
    "def FastTree(execute = True):\n",
    "    \"\"\"When execute is True, this function runs the FastTree executable to perform PTI\"\"\"\n",
    "    \n",
    "    if execute:\n",
    "        \n",
    "        #path to FastTree_exe\n",
    "        FastTree = os.getcwd() + '/FastTree' #'/Users/winde/Alex/Doctoraat/PyEED/Jupyter Notebooks/FastTree'\n",
    "        \n",
    "        #name of the inputfile\n",
    "        inputfile = os.path.join(jobname, f\"CAZy_{jobname}_aligned.fasta\") #os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_{cutoff}_aligned.fasta\")\n",
    "        \n",
    "        #name of the outputfile\n",
    "        outputfile = os.path.join(jobname, f\"CAZy_{jobname}_phyltree.nwk\") #os.path.join(jobname, f\"CAZy_{family}_{taxsubset}_phyltree.nwk\")\n",
    "        \n",
    "        #build a phylogenetic tree using FastTree\n",
    "        fasttree_process = Popen([FastTree, \"-quiet\", \"-out\", outputfile, inputfile], stdout=PIPE, stderr=PIPE)\n",
    "        stdout, stderr = fasttree_process.communicate()\n",
    "        \n",
    "        print(f\"{outputfile} finished!\")\n",
    "    \n",
    "    return \n",
    "\n",
    "phylogenetictree = FastTree(execute)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "a3a46531",
   "metadata": {},
   "source": [
    "# Domain visualization"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 82,
   "id": "1177fea6",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/Users/winde/opt/anaconda3/lib/python3.9/site-packages/scipy/__init__.py:146: UserWarning: A NumPy version >=1.16.5 and <1.23.0 is required for this version of SciPy (detected version 1.26.4\n",
      "  warnings.warn(f\"A NumPy version >={np_minversion} and <{np_maxversion}\"\n"
     ]
    }
   ],
   "source": [
    "#This can only be executed when a phylogenetic tree is constructed\n",
    "import ete3\n",
    "from ete3 import Tree, SeqMotifFace, TreeStyle, add_face_to_node, TextFace\n",
    "\n",
    "phyltree = os.path.join(jobname, f\"CAZy_{jobname}_phyltree.nwk\")\n",
    "proteinseq = os.path.join(jobname, f\"CAZy_{jobname}_inclchar_selected.fasta\")\n",
    "\n",
    "def parse_prot_seq(fastafile):\n",
    "    \"\"\"Parses through the fastafile containing the protein sequences\"\"\"\n",
    "    \n",
    "    with open(fastafile, 'r') as f:\n",
    "        sequences = SeqIO.parse(f, \"fasta\")\n",
    "        modified_sequences = []\n",
    "        \n",
    "        for seq_record in sequences:\n",
    "            modified_sequences.append(seq_record)\n",
    "    \n",
    "    return modified_sequences\n",
    "    \n",
    "def get_motifs(protein, curated_domains, shapedict, colordict):\n",
    "    \"\"\"This function gives a shape and color to each domain found in the protein sequences. It creates a protein motif\n",
    "    that annotates the phylogenetic tree\"\"\"\n",
    "    numberofshapes = len(shapedict)\n",
    "    numberofcolors = len(colordict)\n",
    "    \n",
    "    shapes = ['[]', 'o', '()', '^', '<>', 'v']\n",
    "    colors =  ['red', 'green', 'blue', 'yellow', 'purple', 'orange', 'pink', 'cyan', 'magenta', 'gray', 'black']\n",
    "    \n",
    "    proteinmotif = []\n",
    "    \n",
    "    for key, value in protein.items():\n",
    "        for domains in value:\n",
    "            domainname = domains[1]\n",
    "            \n",
    "            #retrieve the curated name\n",
    "            for umbrellaname, includednames in curated_domains.items():\n",
    "                \n",
    "                #go over all the names that were included in a list to the corresponding umbrella domain name (key)\n",
    "                for name in includednames:\n",
    "                    if name == domainname:\n",
    "                        domainname = umbrellaname\n",
    "                        \n",
    "            domainstart = domains[0][0]\n",
    "            domainend = domains[0][1]\n",
    "            \n",
    "            if domainname not in shapedict:\n",
    "                shapedict[domainname] = shapes[numberofshapes%len(shapes)]\n",
    "                \n",
    "            if domainname not in colordict:\n",
    "                colordict[domainname] = colors[numberofcolors%len(colors)]\n",
    "            \n",
    "            # [seq.start, seq.end, shape, width, height, fgcolor, bgcolor]\n",
    "            domainmotif = [\n",
    "                domainstart, domainend, shapedict[domainname], None, 15, colordict[domainname], colordict[domainname],f'arial|20|white|{domainname}']\n",
    "           \n",
    "            proteinmotif.append(domainmotif)\n",
    "\n",
    "\n",
    "    return proteinmotif\n",
    "\n",
    "def domain_vis(tree, finaldomainoutput, curated_domains, proteinsequences, execute = True):\n",
    "    \"\"\"Function gathers all protein motifs and assembles them to annotate the phylogenetic tree\"\"\"\n",
    "    \n",
    "    if execute:\n",
    "    \n",
    "        protseq = parse_prot_seq(proteinsequences)\n",
    "        seqmotifsdict = {}\n",
    "\n",
    "        #inputtree\n",
    "        t = Tree(tree)\n",
    "\n",
    "        shapedict = {}\n",
    "        colordict = {}\n",
    "\n",
    "        for key, value in finaldomainoutput.items():\n",
    "\n",
    "            domotif = get_motifs({key:value},curated_domains, shapedict, colordict)\n",
    "\n",
    "            for seq_record in protseq:\n",
    "\n",
    "                if seq_record.id.find('_') >2: \n",
    "                    proteinidentifier = seq_record.id.split('_')[0]\n",
    "\n",
    "                else:\n",
    "                    proteinidentifier = seq_record.id.split('_')[0]+'_'+seq_record.id.split('_')[1]\n",
    "                    #print(proteinidentifier)\n",
    "\n",
    "                if proteinidentifier == key:\n",
    "\n",
    "                    seq = str(seq_record.seq)\n",
    "                    leaf = seq_record.id\n",
    "                    seqmotifsdict[leaf] = domotif\n",
    "\n",
    "                    seqFace = SeqMotifFace(seq, motifs=domotif, seq_format=\"-\")\n",
    "                    (t & leaf).add_face(seqFace, 0, \"aligned\")\n",
    "        \n",
    "        return t\n",
    "\n",
    "if go == True:\n",
    "   \n",
    "    domainvisualisation_in_tree = domain_vis(phyltree, finaldomainarchitecture, curated_domains, proteinseq, execute)\n",
    "\n",
    "else:    \n",
    "    \n",
    "    domainvisualisation_in_tree = domain_vis(phyltree, finaldomainarchitecture, curated_domains, proteinseq, execute)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "7bbee687",
   "metadata": {},
   "outputs": [],
   "source": [
    "def ete3_visualisation(domainvisualisation, execute = True):\n",
    "    \"\"\"This function opens a ete3 browser tab containing the constructed phylogenetic tree,\n",
    "    annotated with the domain architecture of every protein. This function is executed automatically when \n",
    "    PTI is selected at the input options. \n",
    "    WARNING: the browser tab needs to be closed again before the workflow can be resumed.\"\"\"\n",
    "    \n",
    "    if execute:\n",
    "        \n",
    "        t = domainvisualisation_in_tree\n",
    "\n",
    "\n",
    "        ts = TreeStyle()\n",
    "        ts.show_leaf_name = True\n",
    "\n",
    "        ts.tree_width = 100\n",
    "        ts.branch_vertical_margin = 15\n",
    "\n",
    "        #circular representation \n",
    "        ts.mode = \"c\"\n",
    "        ts.arc_start = -180 # 0 degrees = 3 o'clock\n",
    "        ts.arc_span = 359\n",
    "\n",
    "        #add title\n",
    "        ts.title.add_face(TextFace(f\"{jobname} Phylogenetic Tree\", fsize=20), column=0)\n",
    "\n",
    "        t.show(tree_style=ts)\n",
    "        \n",
    "    return\n",
    "\n",
    "ete3_vis = ete3_visualisation(domainvisualisation_in_tree, execute)\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "eaac5539",
   "metadata": {},
   "source": [
    "# Create iTOL annotation file"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 83,
   "id": "f13d4916",
   "metadata": {},
   "outputs": [],
   "source": [
    "#import the necessary modules\n",
    "from ete3 import Tree, TreeStyle, TextFace, NodeStyle\n",
    "\n",
    "phyltree = os.path.join(jobname, f\"CAZy_{jobname}_phyltree.nwk\")\n",
    "proteinseq = os.path.join(jobname, f\"CAZy_{jobname}_inclchar_selected.fasta\")\n",
    "iTOL_annotation_file = os.path.join(jobname, f\"iTOL_annotation_CAZy_{jobname}.txt\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 84,
   "id": "dd0caa4f",
   "metadata": {},
   "outputs": [
    {
     "ename": "IndentationError",
     "evalue": "unexpected indent (2814681551.py, line 19)",
     "output_type": "error",
     "traceback": [
      "\u001b[0;36m  Cell \u001b[0;32mIn[84], line 19\u001b[0;36m\u001b[0m\n\u001b[0;31m    '#352310', '#4F0B79', '#CE07F3', '#12FC4F', '#79D626', '#4C45FE', '#DDFBE6', '#0842AF', '#83634C', '#82D4FF']\u001b[0m\n\u001b[0m    ^\u001b[0m\n\u001b[0;31mIndentationError\u001b[0m\u001b[0;31m:\u001b[0m unexpected indent\n"
     ]
    }
   ],
   "source": [
    "def parse_prot_seq(fastafile):\n",
    "    \"\"\"Parses through the fastafile containing the protein sequences\"\"\"\n",
    "    \n",
    "    with open(fastafile, 'r') as f:\n",
    "        sequences = SeqIO.parse(f, \"fasta\")\n",
    "        modified_sequences = []\n",
    "        \n",
    "        for seq_record in sequences:\n",
    "            modified_sequences.append(seq_record)\n",
    "    \n",
    "    return modified_sequences\n",
    "    \n",
    "def get_motifs(protein, curated_domains, shapedictionary, colordictionary):\n",
    "    \"\"\"This function gives a shape and color to each domain found in the protein sequences. It creates a protein motif\n",
    "    that annotates the phylogenetic tree in iTOL\"\"\"\n",
    "    \n",
    "    shapes = ['RE', 'EL', 'HH', 'HV', 'DI', 'TR', 'TL', 'PL', 'PR', 'PU', 'PD', 'OC']\n",
    "    colors = ['#BF0F0F', '#217D3B', '#23A5D9', '#F2C641', '#A276DB', '#D9560B', '#F294B6', '#1DF2DD', '#E80C7A', '#A6A6A6', '#000000',\n",
    "              '#352310', '#4F0B79', '#CE07F3', '#12FC4F', '#79D626', '#4C45FE', '#DDFBE6', '#0842AF', '#83634C', '#82D4FF']\n",
    "    \n",
    "    proteinmotif = ''\n",
    "    shapedict = shapedictionary\n",
    "    colordict = colordictionary\n",
    "    \n",
    "    for key, value in protein.items():\n",
    "        for domains in value:\n",
    "            domainname = domains[1]\n",
    "            \n",
    "            #retrieve the curated name\n",
    "            for umbrellaname, includednames in curated_domains.items():\n",
    "                \n",
    "                #go over all the names that were included in a list to the corresponding umbrella domain name (key)\n",
    "                for name in includednames:\n",
    "                    if name == domainname:\n",
    "                        domainname = umbrellaname\n",
    "                        \n",
    "            domainstart = domains[0][0]\n",
    "            domainend = domains[0][1]\n",
    "            \n",
    "            numberofshapes = len(shapedict)\n",
    "            numberofcolors = len(colordict)\n",
    "            \n",
    "            if domainname not in shapedict:\n",
    "                shapedict[domainname] = shapes[numberofshapes%len(shapes)]\n",
    "                \n",
    "            if domainname not in colordict:\n",
    "                colordict[domainname] = colors[numberofcolors%len(colors)]\n",
    "            \n",
    "            # shapedict[domainname]|domainstart|domainend|colordict[domainname]|domainname\n",
    "            domainmotif = f'{shapedict[domainname]}|{domainstart}|{domainend}|{colordict[domainname]}|{domainname}'\n",
    "            \n",
    "           \n",
    "            proteinmotif += '\\t' + domainmotif\n",
    "\n",
    "    return proteinmotif\n",
    "\n",
    "def domain_vis(tree, finaldomainoutput, curated_domains, proteinsequences, execute = True):\n",
    "    \"\"\"Function gathers all protein motifs and assembles them to annotate the phylogenetic tree\"\"\"\n",
    "    \n",
    "    protseq = parse_prot_seq(proteinsequences)\n",
    "    seqmotifsdict = {}\n",
    "    \n",
    "    #inputtree\n",
    "    t = Tree(tree)\n",
    "    \n",
    "    shapedictionary = {}\n",
    "    colordictionary = {}\n",
    "    iTOL_output = ''\n",
    "    iTOL_file = f\"\"\"DATASET_DOMAINS\n",
    "SEPARATOR TAB\n",
    "DATASET_LABEL\tSMART architecture export\n",
    "COLOR\t#0000ff\n",
    "BORDER_WIDTH\t1\n",
    "GRADIENT_FILL\t1\n",
    "SHOW_DOMAIN_LABELS\t1\n",
    "#Check iTOL help page for further dataset options\n",
    "LEGEND_TITLE\t {jobname} domains\n",
    "\"\"\"\n",
    "    \n",
    "    for key, value in finaldomainoutput.items():\n",
    "        \n",
    "        domotif = get_motifs({key:value},curated_domains, shapedictionary, colordictionary)\n",
    "        \n",
    "        for seq_record in protseq:\n",
    "            \n",
    "            if seq_record.id.find('_') >2: \n",
    "                proteinidentifier = seq_record.id.split('_')[0]\n",
    "                \n",
    "            else:\n",
    "                proteinidentifier = seq_record.id.split('_')[0]+'_'+seq_record.id.split('_')[1]\n",
    "\n",
    "            if proteinidentifier == key:\n",
    "               \n",
    "                len_seq = len(str(seq_record.seq))\n",
    "                leaf = seq_record.id\n",
    "                \n",
    "                iTOL_output += str(leaf) + '\\t' + str(len_seq) + '\\t' + domotif + '\\n'\n",
    "                \n",
    "            \n",
    "    iTOL_file += 'LEGEND_LABELS' + '\\t' + '\\t'        \n",
    "    for key, value in shapedictionary.items():\n",
    "        iTOL_file += key + '\\t'\n",
    "        \n",
    "    iTOL_file += '\\n' + 'LEGEND_SHAPES' + '\\t' + '\\t'        \n",
    "    for key, value in shapedictionary.items():\n",
    "        iTOL_file += value + '\\t'\n",
    "        \n",
    "    iTOL_file += '\\n' + 'LEGEND_COLORS' + '\\t' + '\\t'        \n",
    "    for key, value in shapedictionary.items():\n",
    "        iTOL_file += colordictionary[key] + '\\t'\n",
    "        \n",
    "    iTOL_file += '\\n' + 'DATA' + '\\n' + iTOL_output\n",
    "    \n",
    "    #print(shapedictionary)\n",
    "    #print(colordictionary)\n",
    "    #print(iTOL_file)\n",
    "    return iTOL_file\n",
    "\n",
    "def characterized_labeling(phyltree, characterizedECnumbers, execute = True):\n",
    "    #inputtree\n",
    "    t = Tree(phyltree)\n",
    "    \n",
    "    with open(os.path.join(jobname, f\"Characterized_{family}_GenBankID_file.txt\"), 'r') as file:\n",
    "        \n",
    "        colors =  ['#BF0F0F', '#217D3B', '#23A5D9', '#F2C641', '#A276DB', '#D9560B', '#F294B6', '#1DF2DD', '#E80C7A', '#A6A6A6',\n",
    "                   '#352310', '#4F0B79', '#CE07F3', '#12FC4F', '#79D626', '#4C45FE', '#DDFBE6', '#0842AF', '#83634C', '#82D4FF',\n",
    "                   '#FF5733', '#33FF57', '#5733FF', '#FFD700', '#00BFFF', '#FF69B4', '#8A2BE2', '#7FFF00', '#DC143C', '#20B2AA',\n",
    "                   '#008080', '#FF4500', '#DA70D6', '#4682B4', '#D2691E', '#9ACD32', '#00CED1', '#FF1493', '#1E90FF', '#B22222',\n",
    "                   '#FF6347', '#00FF7F', '#8B4513', '#2E8B57', '#6A5ACD', '#FFDAB9', '#7B68EE', '#32CD32', '#FF00FF', '#FFDEAD']\n",
    "        colordict = {}\n",
    "        outputfile = f\"\"\"DATASET_STYLE\n",
    "SEPARATOR SPACE\n",
    "DATASET_LABEL Characterized enzymes\n",
    "COLOR #0000ff\n",
    "BORDER_WIDTH 1\n",
    "GRADIENT_FILL 1\n",
    "SHOW_DOMAIN_LABELS 1\n",
    "#Check iTOL help page for further dataset options\n",
    "LEGEND_TITLE {jobname} characterized enzymes\n",
    "\"\"\"\n",
    "        tempoutput = ''\n",
    "        for ID in file:\n",
    "            ID = ID.strip()\n",
    "\n",
    "            if ID in characterizedECnumbers.keys(): #should be: ID in characterizedECnumbers\n",
    "                numberofcolors = len(colordict)\n",
    "                ecnumber = characterizedECnumbers[ID].split(' ')[0]\n",
    "                #print the identifiers that contain multiple EC numbers\n",
    "                if len(characterizedECnumbers[ID].split(' ')) > 1:\n",
    "                    print(f'{ID} has multiple EC numbers: {characterizedECnumbers[ID]}. EC number {ecnumber} will be used for annotation.')\n",
    "                if ecnumber not in colordict:\n",
    "                    colordict[ecnumber] = colors[numberofcolors%len(colors)]\n",
    "                \n",
    "            #color the labels of characterized sequences according to their activity\n",
    "            for node in t.traverse():\n",
    "                if node.is_leaf():\n",
    "                    if ID in node.name:\n",
    "                        tempoutput += node.name + ' ' + 'label'+ ' ' + 'node' + ' '+ str(colordict[ecnumber]) + ' ' +  '1' + ' ' + 'bold' + '\\n'\n",
    "    \n",
    "    outputfile += 'LEGEND_LABELS' + ' '        \n",
    "    for key, value in colordict.items():\n",
    "        outputfile += key + ' '\n",
    "    \n",
    "    outputfile += '\\n' + 'LEGEND_SHAPES' + ' ' \n",
    "    count = 1\n",
    "    for key, value in colordict.items():\n",
    "        outputfile += str(count) + ' '\n",
    "        #count += 1\n",
    "        \n",
    "    outputfile += '\\n' + 'LEGEND_COLORS' + ' '        \n",
    "    for key, value in colordict.items():\n",
    "        outputfile += colordict[key] + ' '\n",
    "    \n",
    "    outputfile += '\\n' + 'DATA' + '\\n' + tempoutput \n",
    "    \n",
    "    #print(colordict)\n",
    "    #print(outputfile)\n",
    "    return outputfile\n",
    "\n",
    "iTOL = domain_vis(phyltree, finaldomainarchitecture, curated_domains, proteinseq, execute)\n",
    "\n",
    "if execute: \n",
    "    \n",
    "    with open(iTOL_annotation_file, 'w') as f:\n",
    "        f.write(iTOL)\n",
    "        print(f'{iTOL_annotation_file} finished!')\n",
    "\n",
    "if go == True:\n",
    "    \n",
    "    characterized_annotation = characterized_labeling(phyltree, characterizedECnumbers, execute) \n",
    "    #create an annotation file so that the leaf labels of characterized enzymes are colored by activity\n",
    "    itolout = os.path.join(jobname, f\"iTOL_annotation_CAZy_{jobname}_characterized.txt\")\n",
    "    with open(itolout,'w') as r:\n",
    "        r.write(characterized_annotation)\n",
    "        print(f'{itolout} finished!')\n",
    "    "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "3f5d237c",
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
 "metadata": {
  "celltoolbar": "Raw-celnotatie",
  "kernelspec": {
   "display_name": "Python (myenv)",
   "language": "python",
   "name": "myenv"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.9.7"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 5
}