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outputTest.xml
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<?xml version="1.0" encoding="UTF-8"?>
<!-- Created by BioNetGen 2.1.7 -->
<sbml xmlns="http://www.sbml.org/sbml/level3" level="3" version="1">
<Model>
<ListOfParameters>
<Parameter id="egf_0" type="Constant" value="1.2e6"/>
<Parameter id="egfr_0" type="Constant" value="1.8e5"/>
<Parameter id="Grb2_0" type="Constant" value="1.0e5"/>
<Parameter id="Shc_0" type="Constant" value="2.7e5"/>
<Parameter id="Sos_0" type="Constant" value="1.3e4"/>
<Parameter id="Grb2_Sos_0" type="Constant" value="4.9e4"/>
<Parameter id="kp1" type="Constant" value="1.667e-06"/>
<Parameter id="km1" type="Constant" value="1.06"/>
<Parameter id="kp2" type="Constant" value="5.556e-06"/>
<Parameter id="km2" type="Constant" value="0.1"/>
<Parameter id="kp3" type="Constant" value="0.5"/>
<Parameter id="km3" type="Constant" value="4.505"/>
<Parameter id="kp14" type="Constant" value="3"/>
<Parameter id="km14" type="Constant" value="0.03"/>
<Parameter id="km16" type="Constant" value="0.005"/>
<Parameter id="kp9" type="Constant" value="8.333e-07"/>
<Parameter id="km9" type="Constant" value="0.05"/>
<Parameter id="kp10" type="Constant" value="5.556e-06"/>
<Parameter id="km10" type="Constant" value="0.06"/>
<Parameter id="kp11" type="Constant" value="1.25e-06"/>
<Parameter id="km11" type="Constant" value="0.03"/>
<Parameter id="kp13" type="Constant" value="2.5e-05"/>
<Parameter id="km13" type="Constant" value="0.6"/>
<Parameter id="kp15" type="Constant" value="2.5e-07"/>
<Parameter id="km15" type="Constant" value="0.3"/>
<Parameter id="kp17" type="Constant" value="1.667e-06"/>
<Parameter id="km17" type="Constant" value="0.1"/>
<Parameter id="kp18" type="Constant" value="2.5e-07"/>
<Parameter id="km18" type="Constant" value="0.3"/>
<Parameter id="kp19" type="Constant" value="5.556e-06"/>
<Parameter id="km19" type="Constant" value="0.0214"/>
<Parameter id="kp20" type="Constant" value="6.667e-08"/>
<Parameter id="km20" type="Constant" value="0.12"/>
<Parameter id="kp24" type="Constant" value="5e-06"/>
<Parameter id="km24" type="Constant" value="0.0429"/>
<Parameter id="kp21" type="Constant" value="1.667e-06"/>
<Parameter id="km21" type="Constant" value="0.01"/>
<Parameter id="kp23" type="Constant" value="1.167e-05"/>
<Parameter id="km23" type="Constant" value="0.1"/>
<Parameter id="kp12" type="Constant" value="5.556e-08"/>
<Parameter id="km12" type="Constant" value="0.0015"/>
<Parameter id="kp22" type="Constant" value="1.667e-05"/>
<Parameter id="km22" type="Constant" value="0.064"/>
<Parameter id="loop1" type="Constant" value="(kp9/km9)*(kp10/km10)/((kp11/km11)*(kp12/km12))"/>
<Parameter id="loop2" type="Constant" value="(kp15/km15)*(kp17/km17)/((kp21/km21)*(kp18/km18))"/>
<Parameter id="loop3" type="Constant" value="(kp18/km18)*(kp19/km19)/((kp22/km22)*(kp20/km20))"/>
<Parameter id="loop4" type="Constant" value="(kp12/km12)*(kp23/km23)/((kp22/km22)*(kp21/km21))"/>
<Parameter id="loop5" type="Constant" value="(kp15/km15)*(kp24/km24)/((kp20/km20)*(kp23/km23))"/>
</ListOfParameters>
<ListOfMoleculeTypes>
</ListOfMoleculeTypes>
<ListOfSpecies>
<Species id="S1" concentration="egf_0" name="egf(r)">
<ListofMolecules>
<Molecule id="S1_M1" name="egf" >
<ListOfComponents>
<Component id="S1_M1_C1" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S2" concentration="Grb2_0" name="Grb2(SH2,SH3)">
<ListofMolecules>
<Molecule id="S2_M1" name="Grb2" >
<ListOfComponents>
<Component id="S2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="S2_M1_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S3" concentration="Shc_0" name="Shc(PTB,Y317~Y)">
<ListofMolecules>
<Molecule id="S3_M1" name="Shc" >
<ListOfComponents>
<Component id="S3_M1_C1" name="PTB" numberOfBonds="0" />
<Component id="S3_M1_C2" name="Y317" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S4" concentration="Sos_0" name="Sos(dom)">
<ListofMolecules>
<Molecule id="S4_M1" name="Sos" >
<ListOfComponents>
<Component id="S4_M1_C1" name="dom" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S5" concentration="egfr_0" name="egfr(l,r,Y1068~Y,Y1148~Y)">
<ListofMolecules>
<Molecule id="S5_M1" name="egfr" >
<ListOfComponents>
<Component id="S5_M1_C1" name="l" numberOfBonds="0" />
<Component id="S5_M1_C2" name="r" numberOfBonds="0" />
<Component id="S5_M1_C3" name="Y1068" state= "Y" numberOfBonds="0" />
<Component id="S5_M1_C4" name="Y1148" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
</ListOfSpecies>
<ListOfCompartments>
</ListOfCompartments>
<ListOfReactionRules>
<ReactionRule id="RR1" name="egfrLigRecBind " expression="egfrLigRecBind :egfr(l,r) + egf(r) <-> egfr(l!1,r).egf(r!1) kp1, km1">
<ListOfReactantPatterns>
<ReactantPattern id="RR1_RP1">
<ListofMolecules>
<Molecule id="RR1_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR1_RP1_M1_C1" name="l" numberOfBonds="0" />
<Component id="RR1_RP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR1_RP2">
<ListofMolecules>
<Molecule id="RR1_RP2_M1" name="egf" >
<ListOfComponents>
<Component id="RR1_RP2_M1_C1" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR1_PP1">
<ListofMolecules>
<Molecule id="RR1_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR1_PP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR1_PP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
<Molecule id="RR1_PP1_M2" name="egf" >
<ListOfComponents>
<Component id="RR1_PP1_M2_C1" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR1_PP1_B1" site1="RR1_PP1_M1_C1" site2="RR1_PP1_M2_C1" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.667E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR1_RP2_M1" targetID="RR1_PP1_M2"/>
<MapItem sourceID="RR1_RP2_M1_C1" targetID="RR1_PP1_M2_C1"/>
<MapItem sourceID="RR1_RP1_M1" targetID="RR1_PP1_M1"/>
<MapItem sourceID="RR1_RP1_M1_C1" targetID="RR1_PP1_M1_C1"/>
<MapItem sourceID="RR1_RP1_M1_C2" targetID="RR1_PP1_M1_C2"/>
</Map>
<ListOfOperations>
<AddBond site1="RR1_RP2_M1_C1" site2="RR1_RP1_M1_C1"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR2" name="egfrLigRecBind " expression="egfrLigRecBind :egfr(l,r) + egf(r) <-> egfr(l!1,r).egf(r!1) kp1, km1">
<ListOfReactantPatterns>
<ReactantPattern id="RR2_RP1">
<ListofMolecules>
<Molecule id="RR2_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR2_RP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR2_RP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
<Molecule id="RR2_RP1_M2" name="egf" >
<ListOfComponents>
<Component id="RR2_RP1_M2_C1" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR2_RP1_B1" site1="RR2_RP1_M1_C1" site2="RR2_RP1_M2_C1" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR2_PP1">
<ListofMolecules>
<Molecule id="RR2_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR2_PP1_M1_C1" name="l" numberOfBonds="0" />
<Component id="RR2_PP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
<ProductPattern id="RR2_PP2">
<ListofMolecules>
<Molecule id="RR2_PP2_M1" name="egf" >
<ListOfComponents>
<Component id="RR2_PP2_M1_C1" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.667E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR2_RP1_M2" targetID="RR2_PP2_M1"/>
<MapItem sourceID="RR2_RP1_M2_C1" targetID="RR2_PP2_M1_C1"/>
<MapItem sourceID="RR2_RP1_M1" targetID="RR2_PP1_M1"/>
<MapItem sourceID="RR2_RP1_M1_C1" targetID="RR2_PP1_M1_C1"/>
<MapItem sourceID="RR2_RP1_M1_C2" targetID="RR2_PP1_M1_C2"/>
</Map>
<ListOfOperations>
<DeleteBond site1="RR2_PP2_M1_C1" site2="RR2_PP1_M1_C1"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR3" name="RecAggr " expression="RecAggr :egfr(l!1,r) + egfr(l!2,r) <-> egfr(l!1,r!3).egfr(l!2,r!3) kp2,km2">
<ListOfReactantPatterns>
<ReactantPattern id="RR3_RP1">
<ListofMolecules>
<Molecule id="RR3_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR3_RP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR3_RP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR3_RP1_B1" site1="RR3_RP1_M1_C1" site2="" />
</ListofBonds>
</ReactantPattern>
<ReactantPattern id="RR3_RP2">
<ListofMolecules>
<Molecule id="RR3_RP2_M1" name="egfr" >
<ListOfComponents>
<Component id="RR3_RP2_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR3_RP2_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR3_RP2_B1" site1="RR3_RP2_M1_C1" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR3_PP1">
<ListofMolecules>
<Molecule id="RR3_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR3_PP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR3_PP1_M1_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR3_PP1_M2" name="egfr" >
<ListOfComponents>
<Component id="RR3_PP1_M2_C1" name="l" numberOfBonds="1" />
<Component id="RR3_PP1_M2_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR3_PP1_B1" site1="RR3_PP1_M1_C1" site2="" />
<Bond id="RR3_PP1_B2" site1="RR3_PP1_M2_C1" site2="" />
<Bond id="RR3_PP1_B3" site1="RR3_PP1_M1_C2" site2="RR3_PP1_M2_C2" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="5.556E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR3_RP1_M1" targetID="RR3_PP1_M1"/>
<MapItem sourceID="RR3_RP1_M1_C1" targetID="RR3_PP1_M1_C1"/>
<MapItem sourceID="RR3_RP1_M1_C2" targetID="RR3_PP1_M1_C2"/>
<MapItem sourceID="RR3_RP2_M1" targetID="RR3_PP1_M2"/>
<MapItem sourceID="RR3_RP2_M1_C1" targetID="RR3_PP1_M2_C1"/>
<MapItem sourceID="RR3_RP2_M1_C2" targetID="RR3_PP1_M2_C2"/>
</Map>
<ListOfOperations>
<AddBond site1="RR3_RP1_M1_C2" site2="RR3_RP2_M1_C2"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR4" name="RecAggr " expression="RecAggr :egfr(l!1,r) + egfr(l!2,r) <-> egfr(l!1,r!3).egfr(l!2,r!3) kp2,km2">
<ListOfReactantPatterns>
<ReactantPattern id="RR4_RP1">
<ListofMolecules>
<Molecule id="RR4_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR4_RP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR4_RP1_M1_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR4_RP1_M2" name="egfr" >
<ListOfComponents>
<Component id="RR4_RP1_M2_C1" name="l" numberOfBonds="1" />
<Component id="RR4_RP1_M2_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR4_RP1_B1" site1="RR4_RP1_M1_C1" site2="" />
<Bond id="RR4_RP1_B2" site1="RR4_RP1_M2_C1" site2="" />
<Bond id="RR4_RP1_B3" site1="RR4_RP1_M1_C2" site2="RR4_RP1_M2_C2" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR4_PP1">
<ListofMolecules>
<Molecule id="RR4_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR4_PP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR4_PP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR4_PP1_B1" site1="RR4_PP1_M1_C1" site2="" />
</ListofBonds>
</ProductPattern>
<ProductPattern id="RR4_PP2">
<ListofMolecules>
<Molecule id="RR4_PP2_M1" name="egfr" >
<ListOfComponents>
<Component id="RR4_PP2_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR4_PP2_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR4_PP2_B1" site1="RR4_PP2_M1_C1" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="5.556E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR4_RP1_M1" targetID="RR4_PP1_M1"/>
<MapItem sourceID="RR4_RP1_M1_C1" targetID="RR4_PP1_M1_C1"/>
<MapItem sourceID="RR4_RP1_M1_C2" targetID="RR4_PP1_M1_C2"/>
<MapItem sourceID="RR4_RP1_M2" targetID="RR4_PP2_M1"/>
<MapItem sourceID="RR4_RP1_M2_C1" targetID="RR4_PP2_M1_C1"/>
<MapItem sourceID="RR4_RP1_M2_C2" targetID="RR4_PP2_M1_C2"/>
</Map>
<ListOfOperations>
<DeleteBond site1="RR4_PP1_M1_C2" site2="RR4_PP2_M1_C2"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR5" name="PhosY1068 " expression="PhosY1068 :egfr(r!1,Y1068~Y) -> egfr(r!1,Y1068~pY) kp3">
<ListOfReactantPatterns>
<ReactantPattern id="RR5_RP1">
<ListofMolecules>
<Molecule id="RR5_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR5_RP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR5_RP1_M1_C2" name="Y1068" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR5_RP1_B1" site1="RR5_RP1_M1_C1" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR5_PP1">
<ListofMolecules>
<Molecule id="RR5_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR5_PP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR5_PP1_M1_C2" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR5_PP1_B1" site1="RR5_PP1_M1_C1" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="0.5"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR5_RP1_M1" targetID="RR5_PP1_M1"/>
<MapItem sourceID="RR5_RP1_M1_C1" targetID="RR5_PP1_M1_C1"/>
<MapItem sourceID="RR5_RP1_M1_C2" targetID="RR5_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR6" name="PhosY1148 " expression="PhosY1148 :egfr(r!1,Y1148~Y) -> egfr(r!1,Y1148~pY) kp3">
<ListOfReactantPatterns>
<ReactantPattern id="RR6_RP1">
<ListofMolecules>
<Molecule id="RR6_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR6_RP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR6_RP1_M1_C2" name="Y1148" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR6_RP1_B1" site1="RR6_RP1_M1_C1" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR6_PP1">
<ListofMolecules>
<Molecule id="RR6_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR6_PP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR6_PP1_M1_C2" name="Y1148" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR6_PP1_B1" site1="RR6_PP1_M1_C1" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="0.5"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR6_RP1_M1" targetID="RR6_PP1_M1"/>
<MapItem sourceID="RR6_RP1_M1_C1" targetID="RR6_PP1_M1_C1"/>
<MapItem sourceID="RR6_RP1_M1_C2" targetID="RR6_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR7" name="DephosY1068 " expression="DephosY1068 :egfr(Y1068~pY) -> egfr(Y1068~Y) km3">
<ListOfReactantPatterns>
<ReactantPattern id="RR7_RP1">
<ListofMolecules>
<Molecule id="RR7_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR7_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR7_PP1">
<ListofMolecules>
<Molecule id="RR7_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR7_PP1_M1_C1" name="Y1068" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="4.505"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR7_RP1_M1" targetID="RR7_PP1_M1"/>
<MapItem sourceID="RR7_RP1_M1_C1" targetID="RR7_PP1_M1_C1"/>
</Map>
<ListOfOperations>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR8" name="DephosY1148 " expression="DephosY1148 :egfr(Y1148~pY) -> egfr(Y1148~Y) km3">
<ListOfReactantPatterns>
<ReactantPattern id="RR8_RP1">
<ListofMolecules>
<Molecule id="RR8_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR8_RP1_M1_C1" name="Y1148" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR8_PP1">
<ListofMolecules>
<Molecule id="RR8_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR8_PP1_M1_C1" name="Y1148" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="4.505"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR8_RP1_M1" targetID="RR8_PP1_M1"/>
<MapItem sourceID="RR8_RP1_M1_C1" targetID="RR8_PP1_M1_C1"/>
</Map>
<ListOfOperations>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR9" name="SHCegfrtransphos " expression="SHCegfrtransphos :egfr(r!2,Y1148~pY!1).Shc(PTB!1,Y317~Y) -> egfr(r!2,Y1148~pY!1).Shc(PTB!1,Y317~pY) kp14">
<ListOfReactantPatterns>
<ReactantPattern id="RR9_RP1">
<ListofMolecules>
<Molecule id="RR9_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR9_RP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR9_RP1_M1_C2" name="Y1148" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR9_RP1_M2" name="Shc" >
<ListOfComponents>
<Component id="RR9_RP1_M2_C1" name="PTB" numberOfBonds="1" />
<Component id="RR9_RP1_M2_C2" name="Y317" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR9_RP1_B1" site1="RR9_RP1_M1_C2" site2="RR9_RP1_M2_C1" />
<Bond id="RR9_RP1_B2" site1="RR9_RP1_M1_C1" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR9_PP1">
<ListofMolecules>
<Molecule id="RR9_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR9_PP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR9_PP1_M1_C2" name="Y1148" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR9_PP1_M2" name="Shc" >
<ListOfComponents>
<Component id="RR9_PP1_M2_C1" name="PTB" numberOfBonds="1" />
<Component id="RR9_PP1_M2_C2" name="Y317" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR9_PP1_B1" site1="RR9_PP1_M1_C2" site2="RR9_PP1_M2_C1" />
<Bond id="RR9_PP1_B2" site1="RR9_PP1_M1_C1" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="3.0"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR9_RP1_M2" targetID="RR9_PP1_M2"/>
<MapItem sourceID="RR9_RP1_M2_C1" targetID="RR9_PP1_M2_C1"/>
<MapItem sourceID="RR9_RP1_M2_C2" targetID="RR9_PP1_M2_C2"/>
<MapItem sourceID="RR9_RP1_M1" targetID="RR9_PP1_M1"/>
<MapItem sourceID="RR9_RP1_M1_C1" targetID="RR9_PP1_M1_C1"/>
<MapItem sourceID="RR9_RP1_M1_C2" targetID="RR9_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR10" name="SHCtransphos " expression="SHCtransphos :Shc(PTB!1,Y317~pY) -> Shc(PTB!1,Y317~Y) km14">
<ListOfReactantPatterns>
<ReactantPattern id="RR10_RP1">
<ListofMolecules>
<Molecule id="RR10_RP1_M1" name="Shc" >
<ListOfComponents>
<Component id="RR10_RP1_M1_C1" name="PTB" numberOfBonds="1" />
<Component id="RR10_RP1_M1_C2" name="Y317" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR10_RP1_B1" site1="RR10_RP1_M1_C1" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR10_PP1">
<ListofMolecules>
<Molecule id="RR10_PP1_M1" name="Shc" >
<ListOfComponents>
<Component id="RR10_PP1_M1_C1" name="PTB" numberOfBonds="1" />
<Component id="RR10_PP1_M1_C2" name="Y317" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR10_PP1_B1" site1="RR10_PP1_M1_C1" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="0.03"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR10_RP1_M1" targetID="RR10_PP1_M1"/>
<MapItem sourceID="RR10_RP1_M1_C1" targetID="RR10_PP1_M1_C1"/>
<MapItem sourceID="RR10_RP1_M1_C2" targetID="RR10_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR11" name="Y1068bindSH2freeSH3 " expression="Y1068bindSH2freeSH3 :egfr(Y1068~pY) + Grb2(SH2,SH3) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3) kp9,km9">
<ListOfReactantPatterns>
<ReactantPattern id="RR11_RP1">
<ListofMolecules>
<Molecule id="RR11_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR11_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR11_RP2">
<ListofMolecules>
<Molecule id="RR11_RP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR11_RP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR11_RP2_M1_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR11_PP1">
<ListofMolecules>
<Molecule id="RR11_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR11_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR11_PP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR11_PP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR11_PP1_M2_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR11_PP1_B1" site1="RR11_PP1_M1_C1" site2="RR11_PP1_M2_C1" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="8.333E-7"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR11_RP2_M1" targetID="RR11_PP1_M2"/>
<MapItem sourceID="RR11_RP2_M1_C1" targetID="RR11_PP1_M2_C1"/>
<MapItem sourceID="RR11_RP2_M1_C2" targetID="RR11_PP1_M2_C2"/>
<MapItem sourceID="RR11_RP1_M1" targetID="RR11_PP1_M1"/>
<MapItem sourceID="RR11_RP1_M1_C1" targetID="RR11_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<AddBond site1="RR11_RP2_M1_C1" site2="RR11_RP1_M1_C1"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR12" name="Y1068bindSH2freeSH3 " expression="Y1068bindSH2freeSH3 :egfr(Y1068~pY) + Grb2(SH2,SH3) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3) kp9,km9">
<ListOfReactantPatterns>
<ReactantPattern id="RR12_RP1">
<ListofMolecules>
<Molecule id="RR12_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR12_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR12_RP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR12_RP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR12_RP1_M2_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR12_RP1_B1" site1="RR12_RP1_M1_C1" site2="RR12_RP1_M2_C1" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR12_PP1">
<ListofMolecules>
<Molecule id="RR12_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR12_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
<ProductPattern id="RR12_PP2">
<ListofMolecules>
<Molecule id="RR12_PP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR12_PP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR12_PP2_M1_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="8.333E-7"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR12_RP1_M2" targetID="RR12_PP2_M1"/>
<MapItem sourceID="RR12_RP1_M2_C1" targetID="RR12_PP2_M1_C1"/>
<MapItem sourceID="RR12_RP1_M2_C2" targetID="RR12_PP2_M1_C2"/>
<MapItem sourceID="RR12_RP1_M1" targetID="RR12_PP1_M1"/>
<MapItem sourceID="RR12_RP1_M1_C1" targetID="RR12_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<DeleteBond site1="RR12_PP2_M1_C1" site2="RR12_PP1_M1_C1"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR13" name="Y1068bindSH2 " expression="Y1068bindSH2 :egfr(Y1068~pY) + Grb2(SH2,SH3!2) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3!2) kp11,km11">
<ListOfReactantPatterns>
<ReactantPattern id="RR13_RP1">
<ListofMolecules>
<Molecule id="RR13_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR13_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR13_RP2">
<ListofMolecules>
<Molecule id="RR13_RP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR13_RP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR13_RP2_M1_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR13_RP2_B1" site1="RR13_RP2_M1_C2" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR13_PP1">
<ListofMolecules>
<Molecule id="RR13_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR13_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR13_PP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR13_PP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR13_PP1_M2_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR13_PP1_B1" site1="RR13_PP1_M1_C1" site2="RR13_PP1_M2_C1" />
<Bond id="RR13_PP1_B2" site1="RR13_PP1_M2_C2" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.25E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR13_RP2_M1" targetID="RR13_PP1_M2"/>
<MapItem sourceID="RR13_RP2_M1_C1" targetID="RR13_PP1_M2_C1"/>
<MapItem sourceID="RR13_RP2_M1_C2" targetID="RR13_PP1_M2_C2"/>
<MapItem sourceID="RR13_RP1_M1" targetID="RR13_PP1_M1"/>
<MapItem sourceID="RR13_RP1_M1_C1" targetID="RR13_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<AddBond site1="RR13_RP2_M1_C1" site2="RR13_RP1_M1_C1"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR14" name="Y1068bindSH2 " expression="Y1068bindSH2 :egfr(Y1068~pY) + Grb2(SH2,SH3!2) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3!2) kp11,km11">
<ListOfReactantPatterns>
<ReactantPattern id="RR14_RP1">
<ListofMolecules>
<Molecule id="RR14_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR14_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR14_RP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR14_RP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR14_RP1_M2_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR14_RP1_B1" site1="RR14_RP1_M1_C1" site2="RR14_RP1_M2_C1" />
<Bond id="RR14_RP1_B2" site1="RR14_RP1_M2_C2" site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR14_PP1">
<ListofMolecules>
<Molecule id="RR14_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR14_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
<ProductPattern id="RR14_PP2">
<ListofMolecules>
<Molecule id="RR14_PP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR14_PP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR14_PP2_M1_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR14_PP2_B1" site1="RR14_PP2_M1_C2" site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.25E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR14_RP1_M2" targetID="RR14_PP2_M1"/>
<MapItem sourceID="RR14_RP1_M2_C1" targetID="RR14_PP2_M1_C1"/>
<MapItem sourceID="RR14_RP1_M2_C2" targetID="RR14_PP2_M1_C2"/>
<MapItem sourceID="RR14_RP1_M1" targetID="RR14_PP1_M1"/>
<MapItem sourceID="RR14_RP1_M1_C1" targetID="RR14_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<DeleteBond site1="RR14_PP2_M1_C1" site2="RR14_PP1_M1_C1"/>
</ListOfOperations>
</ReactionRule>
<ReactionRule id="RR15" name="Y1068bindSH2SH3binddom " expression="Y1068bindSH2SH3binddom :egfr(Y1068~pY!1).Grb2(SH2!1,SH3) + Sos(dom) <-> egfr(Y1068~pY!1).Grb2(SH2!1,SH3!2).Sos(dom!2) kp10,km10">
<ListOfReactantPatterns>
<ReactantPattern id="RR15_RP1">
<ListofMolecules>
<Molecule id="RR15_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR15_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR15_RP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR15_RP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR15_RP1_M2_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="RR15_RP1_B1" site1="RR15_RP1_M1_C1" site2="RR15_RP1_M2_C1" />
</ListofBonds>
</ReactantPattern>
<ReactantPattern id="RR15_RP2">
<ListofMolecules>
<Molecule id="RR15_RP2_M1" name="Sos" >
<ListOfComponents>
<Component id="RR15_RP2_M1_C1" name="dom" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR15_PP1">
<ListofMolecules>
<Molecule id="RR15_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR15_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR15_PP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR15_PP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR15_PP1_M2_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR15_PP1_M3" name="Sos" >
<ListOfComponents>
<Component id="RR15_PP1_M3_C1" name="dom" numberOfBonds="1" />