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toy-jim.bngl
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toy-jim.bngl
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<?xml version="1.0" encoding="UTF-8"?>
<!-- Created by BioNetGen 2.1.7 -->
<sbml xmlns="http://www.sbml.org/sbml/level3" level="3" version="1">
<ListOfParameters>
<Parameter id="egf_0" type="Constant" value="1200000.0"/>
<Parameter id="egfr_0" type="Constant" value="180000.0"/>
<Parameter id="Grb2_0" type="Constant" value="100000.0"/>
<Parameter id="Shc_0" type="Constant" value="270000.0"/>
<Parameter id="Sos_0" type="Constant" value="13000.0"/>
<Parameter id="Grb2_Sos_0" type="Constant" value="49000.0"/>
<Parameter id="kp1" type="Constant" value="1.667E-6"/>
<Parameter id="km1" type="Constant" value="1.06"/>
<Parameter id="kp2" type="Constant" value="5.556E-6"/>
<Parameter id="km2" type="Constant" value="0.1"/>
<Parameter id="kp3" type="Constant" value="0.5"/>
<Parameter id="km3" type="Constant" value="4.505"/>
<Parameter id="kp14" type="Constant" value="3.0"/>
<Parameter id="km14" type="Constant" value="0.03"/>
<Parameter id="km16" type="Constant" value="0.005"/>
<Parameter id="kp9" type="Constant" value="8.333E-7"/>
<Parameter id="km9" type="Constant" value="0.05"/>
<Parameter id="kp10" type="Constant" value="5.556E-6"/>
<Parameter id="km10" type="Constant" value="0.06"/>
<Parameter id="kp11" type="Constant" value="1.25E-6"/>
<Parameter id="km11" type="Constant" value="0.03"/>
<Parameter id="kp13" type="Constant" value="2.5E-5"/>
<Parameter id="km13" type="Constant" value="0.6"/>
<Parameter id="kp15" type="Constant" value="2.5E-7"/>
<Parameter id="km15" type="Constant" value="0.3"/>
<Parameter id="kp17" type="Constant" value="1.667E-6"/>
<Parameter id="km17" type="Constant" value="0.1"/>
<Parameter id="kp18" type="Constant" value="2.5E-7"/>
<Parameter id="km18" type="Constant" value="0.3"/>
<Parameter id="kp19" type="Constant" value="5.556E-6"/>
<Parameter id="km19" type="Constant" value="0.0214"/>
<Parameter id="kp20" type="Constant" value="6.667E-8"/>
<Parameter id="km20" type="Constant" value="0.12"/>
<Parameter id="kp24" type="Constant" value="5.0E-6"/>
<Parameter id="km24" type="Constant" value="0.0429"/>
<Parameter id="kp21" type="Constant" value="1.667E-6"/>
<Parameter id="km21" type="Constant" value="0.01"/>
<Parameter id="kp23" type="Constant" value="1.167E-5"/>
<Parameter id="km23" type="Constant" value="0.1"/>
<Parameter id="kp12" type="Constant" value="5.556E-8"/>
<Parameter id="km12" type="Constant" value="0.0015"/>
<Parameter id="kp22" type="Constant" value="1.667E-5"/>
<Parameter id="km22" type="Constant" value="0.064"/>
<Parameter id="loop1" type="Constant" value="0.9999599999999998"/>
<Parameter id="loop2" type="Constant" value="0.09999999999999999"/>
<Parameter id="loop3" type="Constant" value="1.4950729457847869"/>
<Parameter id="loop4" type="Constant" value="0.09955214188116183"/>
<Parameter id="loop5" type="Constant" value="1.497998577579046"/>
</ListOfParameters>
<ListOfMoleculeTypes>
</ListOfMoleculeTypes>
<ListOfSpecies>
<Species id="S1" concentration="egf_0" name="egf(r)">
<ListofMolecules>
<Molecule id="S1_M1" name="egf" >
<ListOfComponents>
<Component id="S1_M1_C1" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S2" concentration="Grb2_0" name="Grb2(SH2,SH3)">
<ListofMolecules>
<Molecule id="S2_M1" name="Grb2" >
<ListOfComponents>
<Component id="S2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="S2_M1_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S3" concentration="Shc_0" name="Shc(PTB,Y317~Y)">
<ListofMolecules>
<Molecule id="S3_M1" name="Shc" >
<ListOfComponents>
<Component id="S3_M1_C1" name="PTB" numberOfBonds="0" />
<Component id="S3_M1_C2" name="Y317" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S4" concentration="Sos_0" name="Sos(dom)">
<ListofMolecules>
<Molecule id="S4_M1" name="Sos" >
<ListOfComponents>
<Component id="S4_M1_C1" name="dom" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
<Species id="S5" concentration="egfr_0" name="egfr(l,r,Y1068~Y,Y1148~Y)">
<ListofMolecules>
<Molecule id="S5_M1" name="egfr" >
<ListOfComponents>
<Component id="S5_M1_C1" name="l" numberOfBonds="0" />
<Component id="S5_M1_C2" name="r" numberOfBonds="0" />
<Component id="S5_M1_C3" name="Y1068" state= "Y" numberOfBonds="0" />
<Component id="S5_M1_C4" name="Y1148" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</Species>
</ListOfSpecies>
<ListOfCompartments>
</ListOfCompartments>
<ListOfReactionRules>
<ReactionRule id="RR1" name="egfrLigRecBind">
<ListOfReactantPatterns>
<ReactantPattern id="RR1_RP1">
<ListofMolecules>
<Molecule id="RR1_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR1_RP1_M1_C1" name="l" numberOfBonds="0" />
<Component id="RR1_RP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR1_RP2">
<ListofMolecules>
<Molecule id="RR1_RP2_M1" name="egf" >
<ListOfComponents>
<Component id="RR1_RP2_M1_C1" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR1_PP1">
<ListofMolecules>
<Molecule id="RR1_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR1_PP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR1_PP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
<Molecule id="RR1_PP1_M2" name="egf" >
<ListOfComponents>
<Component id="RR1_PP1_M2_C1" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR1_PP1_M1_C1", site2="RR1_PP1_M2_C1" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.667E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR1_RP2_M1" targetID="RR1_PP1_M2"/>
<MapItem sourceID="RR1_RP2_M1_C1" targetID="RR1_PP1_M2_C1"/>
<MapItem sourceID="RR1_RP1_M1" targetID="RR1_PP1_M1"/>
<MapItem sourceID="RR1_RP1_M1_C1" targetID="RR1_PP1_M1_C1"/>
<MapItem sourceID="RR1_RP1_M1_C2" targetID="RR1_PP1_M1_C2"/>
</Map>
<ListOfOperations>
<AddBond site1="RR1_RP2_M1_C1" site2="RR1_RP1_M1_C1"/>
</ListOfOperations>
<ReactionRule id="RR2" name="egfrLigRecBind(reverse)">
<ListOfReactantPatterns>
<ProductPattern id="RR2_RP1">
<ListofMolecules>
<Molecule id="RR2_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR2_RP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR2_RP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
<Molecule id="RR2_RP1_M2" name="egf" >
<ListOfComponents>
<Component id="RR2_RP1_M2_C1" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR2_PP1_M1_C1", site2="RR2_RP1_M2_C1" />
</ListofBonds>
</ProductPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ReactantPattern id="RR2_PP1">
<ListofMolecules>
<Molecule id="RR2_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR2_PP1_M1_C1" name="l" numberOfBonds="0" />
<Component id="RR2_PP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR2_PP2">
<ListofMolecules>
<Molecule id="RR2_PP2_M1" name="egf" >
<ListOfComponents>
<Component id="RR2_PP2_M1_C1" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.667E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR2_RP1_M2" targetID="RR2_PP2_M1"/>
<MapItem sourceID="RR2_RP1_M2_C1" targetID="RR2_PP2_M1_C1"/>
<MapItem sourceID="RR2_RP1_M1" targetID="RR2_PP1_M1"/>
<MapItem sourceID="RR2_RP1_M1_C1" targetID="RR2_PP1_M1_C1"/>
<MapItem sourceID="RR2_RP1_M1_C2" targetID="RR2_PP1_M1_C2"/>
</Map>
<ListOfOperations>
<AddBond site1="RR2_RP2_M1_C1" site2="RR2_RP1_M1_C1"/>
</ListOfOperations>
<ReactionRule id="RR3" name="RecAggr">
<ListOfReactantPatterns>
<ReactantPattern id="RR3_RP1">
<ListofMolecules>
<Molecule id="RR3_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR3_RP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR3_RP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR3_RP1_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
<ReactantPattern id="RR3_RP2">
<ListofMolecules>
<Molecule id="RR3_RP2_M1" name="egfr" >
<ListOfComponents>
<Component id="RR3_RP2_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR3_RP2_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR3_RP2_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR3_PP1">
<ListofMolecules>
<Molecule id="RR3_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR3_PP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR3_PP1_M1_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR3_PP1_M2" name="egfr" >
<ListOfComponents>
<Component id="RR3_PP1_M2_C1" name="l" numberOfBonds="1" />
<Component id="RR3_PP1_M2_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR3_PP1_M1_C1", site2="" />
<Bond id="_B2" site1="RR3_PP1_M2_C1", site2="" />
<Bond id="_B3" site1="RR3_PP1_M1_C2", site2="RR3_PP1_M2_C2" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="5.556E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR3_RP1_M1" targetID="RR3_PP1_M1"/>
<MapItem sourceID="RR3_RP1_M1_C1" targetID="RR3_PP1_M1_C1"/>
<MapItem sourceID="RR3_RP1_M1_C2" targetID="RR3_PP1_M1_C2"/>
<MapItem sourceID="RR3_RP2_M1" targetID="RR3_PP1_M2"/>
<MapItem sourceID="RR3_RP2_M1_C1" targetID="RR3_PP1_M2_C1"/>
<MapItem sourceID="RR3_RP2_M1_C2" targetID="RR3_PP1_M2_C2"/>
</Map>
<ListOfOperations>
<AddBond site1="RR3_RP1_M1_C2" site2="RR3_RP2_M1_C2"/>
</ListOfOperations>
<ReactionRule id="RR4" name="RecAggr(reverse)">
<ListOfReactantPatterns>
<ProductPattern id="RR4_RP1">
<ListofMolecules>
<Molecule id="RR4_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR4_RP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR4_RP1_M1_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR4_RP1_M2" name="egfr" >
<ListOfComponents>
<Component id="RR4_RP1_M2_C1" name="l" numberOfBonds="1" />
<Component id="RR4_RP1_M2_C2" name="r" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR4_RP1_M1_C1", site2="" />
<Bond id="_B2" site1="RR4_RP1_M2_C1", site2="" />
<Bond id="_B3" site1="RR4_PP1_M1_C2", site2="RR4_RP1_M2_C2" />
</ListofBonds>
</ProductPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ReactantPattern id="RR4_PP1">
<ListofMolecules>
<Molecule id="RR4_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR4_PP1_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR4_PP1_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR4_PP1_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
<ReactantPattern id="RR4_PP2">
<ListofMolecules>
<Molecule id="RR4_PP2_M1" name="egfr" >
<ListOfComponents>
<Component id="RR4_PP2_M1_C1" name="l" numberOfBonds="1" />
<Component id="RR4_PP2_M1_C2" name="r" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR4_PP2_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="5.556E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR4_RP1_M1" targetID="RR4_PP1_M1"/>
<MapItem sourceID="RR4_RP1_M1_C1" targetID="RR4_PP1_M1_C1"/>
<MapItem sourceID="RR4_RP1_M1_C2" targetID="RR4_PP1_M1_C2"/>
<MapItem sourceID="RR4_RP1_M2" targetID="RR4_PP2_M1"/>
<MapItem sourceID="RR4_RP1_M2_C1" targetID="RR4_PP2_M1_C1"/>
<MapItem sourceID="RR4_RP1_M2_C2" targetID="RR4_PP2_M1_C2"/>
</Map>
<ListOfOperations>
<AddBond site1="RR4_RP1_M1_C2" site2="RR4_RP2_M1_C2"/>
</ListOfOperations>
<ReactionRule id="RR5" name="PhosY1068">
<ListOfReactantPatterns>
<ReactantPattern id="RR5_RP1">
<ListofMolecules>
<Molecule id="RR5_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR5_RP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR5_RP1_M1_C2" name="Y1068" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR5_RP1_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR5_PP1">
<ListofMolecules>
<Molecule id="RR5_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR5_PP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR5_PP1_M1_C2" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR5_PP1_M1_C1", site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="0.5"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR5_RP1_M1" targetID="RR5_PP1_M1"/>
<MapItem sourceID="RR5_RP1_M1_C1" targetID="RR5_PP1_M1_C1"/>
<MapItem sourceID="RR5_RP1_M1_C2" targetID="RR5_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
<ReactionRule id="RR6" name="PhosY1148">
<ListOfReactantPatterns>
<ReactantPattern id="RR6_RP1">
<ListofMolecules>
<Molecule id="RR6_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR6_RP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR6_RP1_M1_C2" name="Y1148" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR6_RP1_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR6_PP1">
<ListofMolecules>
<Molecule id="RR6_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR6_PP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR6_PP1_M1_C2" name="Y1148" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR6_PP1_M1_C1", site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="0.5"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR6_RP1_M1" targetID="RR6_PP1_M1"/>
<MapItem sourceID="RR6_RP1_M1_C1" targetID="RR6_PP1_M1_C1"/>
<MapItem sourceID="RR6_RP1_M1_C2" targetID="RR6_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
<ReactionRule id="RR7" name="DephosY1068">
<ListOfReactantPatterns>
<ReactantPattern id="RR7_RP1">
<ListofMolecules>
<Molecule id="RR7_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR7_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR7_PP1">
<ListofMolecules>
<Molecule id="RR7_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR7_PP1_M1_C1" name="Y1068" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="4.505"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR7_RP1_M1" targetID="RR7_PP1_M1"/>
<MapItem sourceID="RR7_RP1_M1_C1" targetID="RR7_PP1_M1_C1"/>
</Map>
<ListOfOperations>
</ListOfOperations>
<ReactionRule id="RR8" name="DephosY1148">
<ListOfReactantPatterns>
<ReactantPattern id="RR8_RP1">
<ListofMolecules>
<Molecule id="RR8_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR8_RP1_M1_C1" name="Y1148" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR8_PP1">
<ListofMolecules>
<Molecule id="RR8_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR8_PP1_M1_C1" name="Y1148" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="4.505"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR8_RP1_M1" targetID="RR8_PP1_M1"/>
<MapItem sourceID="RR8_RP1_M1_C1" targetID="RR8_PP1_M1_C1"/>
</Map>
<ListOfOperations>
</ListOfOperations>
<ReactionRule id="RR9" name="SHCegfrtransphos">
<ListOfReactantPatterns>
<ReactantPattern id="RR9_RP1">
<ListofMolecules>
<Molecule id="RR9_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR9_RP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR9_RP1_M1_C2" name="Y1148" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR9_RP1_M2" name="Shc" >
<ListOfComponents>
<Component id="RR9_RP1_M2_C1" name="PTB" numberOfBonds="1" />
<Component id="RR9_RP1_M2_C2" name="Y317" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR9_RP1_M1_C2", site2="RR9_RP1_M2_C1" />
<Bond id="_B2" site1="RR9_RP1_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR9_PP1">
<ListofMolecules>
<Molecule id="RR9_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR9_PP1_M1_C1" name="r" numberOfBonds="1" />
<Component id="RR9_PP1_M1_C2" name="Y1148" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR9_PP1_M2" name="Shc" >
<ListOfComponents>
<Component id="RR9_PP1_M2_C1" name="PTB" numberOfBonds="1" />
<Component id="RR9_PP1_M2_C2" name="Y317" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR9_PP1_M1_C2", site2="RR9_PP1_M2_C1" />
<Bond id="_B2" site1="RR9_PP1_M1_C1", site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="3.0"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR9_RP1_M2" targetID="RR9_PP1_M2"/>
<MapItem sourceID="RR9_RP1_M2_C1" targetID="RR9_PP1_M2_C1"/>
<MapItem sourceID="RR9_RP1_M2_C2" targetID="RR9_PP1_M2_C2"/>
<MapItem sourceID="RR9_RP1_M1" targetID="RR9_PP1_M1"/>
<MapItem sourceID="RR9_RP1_M1_C1" targetID="RR9_PP1_M1_C1"/>
<MapItem sourceID="RR9_RP1_M1_C2" targetID="RR9_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
<ReactionRule id="RR10" name="SHCtransphos">
<ListOfReactantPatterns>
<ReactantPattern id="RR10_RP1">
<ListofMolecules>
<Molecule id="RR10_RP1_M1" name="Shc" >
<ListOfComponents>
<Component id="RR10_RP1_M1_C1" name="PTB" numberOfBonds="1" />
<Component id="RR10_RP1_M1_C2" name="Y317" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR10_RP1_M1_C1", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR10_PP1">
<ListofMolecules>
<Molecule id="RR10_PP1_M1" name="Shc" >
<ListOfComponents>
<Component id="RR10_PP1_M1_C1" name="PTB" numberOfBonds="1" />
<Component id="RR10_PP1_M1_C2" name="Y317" state= "Y" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR10_PP1_M1_C1", site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="0.03"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR10_RP1_M1" targetID="RR10_PP1_M1"/>
<MapItem sourceID="RR10_RP1_M1_C1" targetID="RR10_PP1_M1_C1"/>
<MapItem sourceID="RR10_RP1_M1_C2" targetID="RR10_PP1_M1_C2"/>
</Map>
<ListOfOperations>
</ListOfOperations>
<ReactionRule id="RR11" name="Y1068bindSH2freeSH3">
<ListOfReactantPatterns>
<ReactantPattern id="RR11_RP1">
<ListofMolecules>
<Molecule id="RR11_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR11_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR11_RP2">
<ListofMolecules>
<Molecule id="RR11_RP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR11_RP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR11_RP2_M1_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR11_PP1">
<ListofMolecules>
<Molecule id="RR11_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR11_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR11_PP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR11_PP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR11_PP1_M2_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR11_PP1_M1_C1", site2="RR11_PP1_M2_C1" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="8.333E-7"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR11_RP2_M1" targetID="RR11_PP1_M2"/>
<MapItem sourceID="RR11_RP2_M1_C1" targetID="RR11_PP1_M2_C1"/>
<MapItem sourceID="RR11_RP2_M1_C2" targetID="RR11_PP1_M2_C2"/>
<MapItem sourceID="RR11_RP1_M1" targetID="RR11_PP1_M1"/>
<MapItem sourceID="RR11_RP1_M1_C1" targetID="RR11_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<AddBond site1="RR11_RP2_M1_C1" site2="RR11_RP1_M1_C1"/>
</ListOfOperations>
<ReactionRule id="RR12" name="Y1068bindSH2freeSH3(reverse)">
<ListOfReactantPatterns>
<ProductPattern id="RR12_RP1">
<ListofMolecules>
<Molecule id="RR12_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR12_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR12_RP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR12_RP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR12_RP1_M2_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR12_PP1_M1_C1", site2="RR12_RP1_M2_C1" />
</ListofBonds>
</ProductPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ReactantPattern id="RR12_PP1">
<ListofMolecules>
<Molecule id="RR12_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR12_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR12_PP2">
<ListofMolecules>
<Molecule id="RR12_PP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR12_PP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR12_PP2_M1_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="8.333E-7"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR12_RP1_M2" targetID="RR12_PP2_M1"/>
<MapItem sourceID="RR12_RP1_M2_C1" targetID="RR12_PP2_M1_C1"/>
<MapItem sourceID="RR12_RP1_M2_C2" targetID="RR12_PP2_M1_C2"/>
<MapItem sourceID="RR12_RP1_M1" targetID="RR12_PP1_M1"/>
<MapItem sourceID="RR12_RP1_M1_C1" targetID="RR12_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<AddBond site1="RR12_RP2_M1_C1" site2="RR12_RP1_M1_C1"/>
</ListOfOperations>
<ReactionRule id="RR13" name="Y1068bindSH2">
<ListOfReactantPatterns>
<ReactantPattern id="RR13_RP1">
<ListofMolecules>
<Molecule id="RR13_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR13_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR13_RP2">
<ListofMolecules>
<Molecule id="RR13_RP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR13_RP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR13_RP2_M1_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR13_RP2_M1_C2", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR13_PP1">
<ListofMolecules>
<Molecule id="RR13_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR13_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR13_PP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR13_PP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR13_PP1_M2_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR13_PP1_M1_C1", site2="RR13_PP1_M2_C1" />
<Bond id="_B2" site1="RR13_PP1_M2_C2", site2="" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.25E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR13_RP2_M1" targetID="RR13_PP1_M2"/>
<MapItem sourceID="RR13_RP2_M1_C1" targetID="RR13_PP1_M2_C1"/>
<MapItem sourceID="RR13_RP2_M1_C2" targetID="RR13_PP1_M2_C2"/>
<MapItem sourceID="RR13_RP1_M1" targetID="RR13_PP1_M1"/>
<MapItem sourceID="RR13_RP1_M1_C1" targetID="RR13_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<AddBond site1="RR13_RP2_M1_C1" site2="RR13_RP1_M1_C1"/>
</ListOfOperations>
<ReactionRule id="RR14" name="Y1068bindSH2(reverse)">
<ListOfReactantPatterns>
<ProductPattern id="RR14_RP1">
<ListofMolecules>
<Molecule id="RR14_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR14_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR14_RP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR14_RP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR14_RP1_M2_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR14_PP1_M1_C1", site2="RR14_RP1_M2_C1" />
<Bond id="_B2" site1="RR14_RP1_M2_C2", site2="" />
</ListofBonds>
</ProductPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ReactantPattern id="RR14_PP1">
<ListofMolecules>
<Molecule id="RR14_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR14_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
<ReactantPattern id="RR14_PP2">
<ListofMolecules>
<Molecule id="RR14_PP2_M1" name="Grb2" >
<ListOfComponents>
<Component id="RR14_PP2_M1_C1" name="SH2" numberOfBonds="0" />
<Component id="RR14_PP2_M1_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR14_PP2_M1_C2", site2="" />
</ListofBonds>
</ReactantPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="1.25E-6"/>
</ListOfRateConstants>
</RateLaw>
<Map>
<MapItem sourceID="RR14_RP1_M2" targetID="RR14_PP2_M1"/>
<MapItem sourceID="RR14_RP1_M2_C1" targetID="RR14_PP2_M1_C1"/>
<MapItem sourceID="RR14_RP1_M2_C2" targetID="RR14_PP2_M1_C2"/>
<MapItem sourceID="RR14_RP1_M1" targetID="RR14_PP1_M1"/>
<MapItem sourceID="RR14_RP1_M1_C1" targetID="RR14_PP1_M1_C1"/>
</Map>
<ListOfOperations>
<AddBond site1="RR14_RP2_M1_C1" site2="RR14_RP1_M1_C1"/>
</ListOfOperations>
<ReactionRule id="RR15" name="Y1068bindSH2SH3binddom">
<ListOfReactantPatterns>
<ReactantPattern id="RR15_RP1">
<ListofMolecules>
<Molecule id="RR15_RP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR15_RP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR15_RP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR15_RP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR15_RP1_M2_C2" name="SH3" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR15_RP1_M1_C1", site2="RR15_RP1_M2_C1" />
</ListofBonds>
</ReactantPattern>
<ReactantPattern id="RR15_RP2">
<ListofMolecules>
<Molecule id="RR15_RP2_M1" name="Sos" >
<ListOfComponents>
<Component id="RR15_RP2_M1_C1" name="dom" numberOfBonds="0" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
</ReactantPattern>
</ListOfReactantPatterns>
<ListOfProductPatterns>
<ProductPattern id="RR15_PP1">
<ListofMolecules>
<Molecule id="RR15_PP1_M1" name="egfr" >
<ListOfComponents>
<Component id="RR15_PP1_M1_C1" name="Y1068" state= "pY" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR15_PP1_M2" name="Grb2" >
<ListOfComponents>
<Component id="RR15_PP1_M2_C1" name="SH2" numberOfBonds="1" />
<Component id="RR15_PP1_M2_C2" name="SH3" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
<Molecule id="RR15_PP1_M3" name="Sos" >
<ListOfComponents>
<Component id="RR15_PP1_M3_C1" name="dom" numberOfBonds="1" />
</ListOfComponents>
</Molecule>
</ListofMolecules>
<ListofBonds>
<Bond id="_B1" site1="RR15_PP1_M1_C1", site2="RR15_PP1_M2_C1" />
<Bond id="_B2" site1="RR15_PP1_M2_C2", site2="RR15_PP1_M3_C1" />
</ListofBonds>
</ProductPattern>
</ListOfProductPatterns>
<RateLaw>
<ListOfRateConstants>
<RateConstant value="5.556E-6"/>
</ListOfRateConstants>