-
Notifications
You must be signed in to change notification settings - Fork 0
Origins of this Project
Dr. Daren Fearon and Dr. Jasmin Aschenbrenner at the Diamond Light Source obtained crystals of the CHIKV nsp3-macrodomain and soaked 1339 fragments to generate the initial dataset. They determined 20 hits in active site, and 20 outside the active site. The protein target is a priority project for the READDI-AViDD antiviral discovery consortium, and the hit triage/validation is slated to start in January 2024.
The aim of the project is to convert the fragments identified into a chemical probe for this protein, helping to kick-start drug discovery efforts.
Construct and Protein Production
Crystallisation of CHIKV nsP3 macrodomain
Fragment Screen and Data Analysis
Fast Forward Fragment Approach
Algorithmic Fragment Elaboration
Grating-coupled interferometry (GCI)
Biological Data Not Yet Incorporated into this Wiki