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The Story So Far
Mat Todd edited this page Jan 16, 2024
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The starting point for the project is the dataset derived from a fragment screen vs the macrodomain carried out at the Diamond Light Source by Daren Fearon and Jasmin Aschenbrenner in late 2023. The data are being refined (January 2024).
The aim of the project is to use these fragments to design a chemical probe binding to the CHIKV nsp3 macrodomain.
Here are a few fragments have been identified so far:
Construct and Protein Production
Crystallisation of CHIKV nsP3 macrodomain
Fragment Screen and Data Analysis
Fast Forward Fragment Approach
Algorithmic Fragment Elaboration
Grating-coupled interferometry (GCI)
Biological Data Not Yet Incorporated into this Wiki