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The Story So Far
Dr. Hadia Almahli @hadiaamahli (Research fellow) in Prof. Matthew Todd's lab at University College London (UCL) is the lead chemist for the CHIKV-nsP3-Macrodomain, will be working on the fragments generated by the Fragment screening which is carried out by Diamond Light Source team. She will study the binding interactions of these fragments with the protein and then use the growing strategies to suggest different types of CHIKV-nsP3- Macrodomain inhibitors. Here are a few fragments have been identified so far:
Construct and Protein Production
Crystallisation of CHIKV nsP3 macrodomain
Fragment Screen and Data Analysis
Fast Forward Fragment Approach
Algorithmic Fragment Elaboration
Grating-coupled interferometry (GCI)
Biological Data Not Yet Incorporated into this Wiki