GPR curation for Carnitine shuttle (2)

[JHL-452b]

Current behavior:

27 genes are discovered to be uncorrelated with their corresponding reactions in Carnitine shuttle.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000197119	Q8N8R3	MAR02649: heptadecenoylcarnitine(7) + L-carnitine <=> heptadecenoylcarnitine(7) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter that is involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. This transporter operates by counter-exchange and uniport mechanisms and plays a role in amino acid import essential for mitochondrial protein synthesis and degradation. However, the reaction provided involves the exchange of heptadecenoylcarnitine and L-carnitine, which are not substrates for the gene's encoded transporter, as it does not transport carnitine or acylcarnitines. Therefore, these functional and catalytic activities do not align with the reaction mentioned.	No
ENSG00000197119	Q8N8R3	MAR02652: heptadecenoylcarnitine(8) + L-carnitine <=> heptadecenoylcarnitine(8) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter specifically involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines. The reaction provided involves the exchange of heptadecenoylcarnitine and L-carnitine, which are not substrates of the gene¡¯s encoded protein, thus indicating that the gene is not related to the reaction.	No
ENSG00000149742	Q8IVM8	MAR02655: L-carnitine + stearoylcarnitine <=> L-carnitine + stearoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149742 encodes for a sodium-independent organic anion transporter that specifically facilitates the transport of sulfated conjugates of xenobiotics and steroid hormones like estrone 3-sulfate and dehydroepiandrosterone sulfate, as well as statin pravastatin. The catalytic activities of this gene involve the exchange of these sulfated compounds with short-chain fatty acids such as butanoate, propanoate, and pentanoate. However, the reaction provided involves the exchange of L-carnitine and stearoylcarnitine, which is unrelated to the functions and catalytic activities of the gene encoded by ENSG00000149742. Therefore, the gene does not correlate with the provided reaction.	No
ENSG00000175003	O15245	MAR02655: L-carnitine + stearoylcarnitine <=> L-carnitine + stearoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000175003 is involved in the transport of various organic cations, including bioactive amines, neurotransmitters, and drugs, through bidirectional electrogenic voltage-dependent mechanisms. However, the reaction specified¡ªL-carnitine + stearoylcarnitine <=> L-carnitine + stearoylcarnitine¡ªdoes not align with the transport functions associated with this gene. The gene's functions do not include the handling or transport of carnitine or its derivatives, which makes it irrelevant to the reaction provided.	No
ENSG00000197119	Q8N8R3	MAR02655: L-carnitine + stearoylcarnitine <=> L-carnitine + stearoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 is annotated to transport arginine, lysine, homoarginine, methylarginine, ornithine, and histidine within the mitochondria by both counter-exchange and uniport mechanisms. It does not transport carnitine or acylcarnitines, as confirmed by multiple PubMed references. The reaction provided involves L-carnitine and stearoylcarnitine, which the gene specifically does not transport, making it not relevant to the reaction.	No
ENSG00000149742	Q8IVM8	MAR02658: L-carnitine + octadecenoylcarnitine(5) <=> L-carnitine + octadecenoylcarnitine(5)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS), as well as short-chain fatty acids (SCFAs) like propionate, butyrate, and valerate. The reactions associated with this gene involve the exchange of sulfated organic components against SCFAs, specifically butanoate, propanoate, and pentanoate. However, the reaction provided involves L-carnitine and octadecenoylcarnitine, which are not substrates or products linked to the transporter activity described for ENSG00000149742. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000197119	Q8N8R3	MAR02658: L-carnitine + octadecenoylcarnitine(5) <=> L-carnitine + octadecenoylcarnitine(5)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter that specifically transports arginine, lysine, homoarginine, methylarginine, and to a much lesser extent, ornithine and histidine. It does not transport carnitine or acylcarnitines according to the provided annotations and evidence from PubMed. The provided reaction involves L-carnitine and octadecenoylcarnitine, substances that this gene does not transport. Therefore, based on the gene's documented function and specificity, it is not relevant to the reaction involving L-carnitine and octadecenoylcarnitine.	No
ENSG00000149742	Q8IVM8	MAR02661: L-carnitine + octadecenoylcarnitine(7) <=> L-carnitine + octadecenoylcarnitine(7)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that has high specificity for sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, and can transport molecules like pravastatin. It specifically handles the exchange of sulfated organic components against short-chain fatty acids. The reactions described for this gene involve the transport of butanoate, propanoate, pentanoate, estrone 3-sulfate, and dehydroepiandrosterone 3-sulfate. However, the provided reaction involves L-carnitine and octadecenoylcarnitine, which do not match the substrates handled by the gene product. Thus, the gene and the reaction are not related.	No
ENSG00000197119	Q8N8R3	MAR02661: L-carnitine + octadecenoylcarnitine(7) <=> L-carnitine + octadecenoylcarnitine(7)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes for a mitochondrial transporter responsible for the transport of amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines. The provided reaction involves the exchange of L-carnitine and octadecenoylcarnitine, which are not substrates or products of the catalytic activities described for this gene. Therefore, there is no relevance between the gene and the reaction.	No
ENSG00000197119	Q8N8R3	MAR02664: L-carnitine + L-oleoylcarnitine <=> L-carnitine + L-oleoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes for a mitochondrial transporter involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or any acylcarnitines. The provided reaction involves L-carnitine and L-oleoylcarnitine, which are not substrates handled by the transporter encoded by this gene. Therefore, the gene is not related to the given reaction.	No
ENSG00000197119	Q8N8R3	MAR02667: (9E)-octadecenoylcarnitine + L-carnitine <=> (9E)-octadecenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter of several basic amino acids including arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, but does not transport carnitine nor acylcarnitines. The provided reaction involves the interchange of (9E)-octadecenoylcarnitine and L-carnitine, which is unrelated to the known substrates and activities of the gene product according to the annotations and catalytic activities listed.	No
ENSG00000197119	Q8N8R3	MAR02670: L-carnitine + octadecenoylcarnitine(11) <=> L-carnitine + octadecenoylcarnitine(11)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter that specifically transports arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, and does not transport carnitine nor acylcarnitines. The reaction provided involves L-carnitine and octadecenoylcarnitine, which are substrates not transported by the gene product according to the given function and catalytic activities.	No
ENSG00000149742	Q8IVM8	MAR02673: (6Z,9Z)-octadecadienoylcarnitine + L-carnitine <=> (6Z,9Z)-octadecadienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter which specifically transports sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS), and is activated by short-chain fatty acids like propionate, butyrate, and valerate. The reactions catalyzed by this transporter involve exchanges of these sulfated compounds with short-chain fatty acids. However, the provided reaction involves the exchange of (6Z,9Z)-octadecadienoylcarnitine and L-carnitine, which are not recognized substrates or products for the transporter encoded by this gene. Thus, the gene is not relevant to the specified reaction.	No
ENSG00000197119	Q8N8R3	MAR02673: (6Z,9Z)-octadecadienoylcarnitine + L-carnitine <=> (6Z,9Z)-octadecadienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter that primarily facilitates the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines. The reaction provided involves L-carnitine and (6Z,9Z)-octadecadienoylcarnitine, which are outside the transport scope of the gene product, making the gene irrelevant to the specified reaction.	No
ENSG00000149742	Q8IVM8	MAR02676: L-carnitine + nonadecanoylcarnitine <=> L-carnitine + nonadecanoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically handles the transport of sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, in exchange for short-chain fatty acids like butanoate, propanoate, and pentanoate. Conversely, the reaction provided involves the interconversion of L-carnitine and nonadecanoylcarnitine, which is unrelated to the transport activities described for the gene. Hence, the gene's function does not align with the specific substrates and products involved in the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02676: L-carnitine + nonadecanoylcarnitine <=> L-carnitine + nonadecanoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter that specifically imports and exports amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines, which includes nonadecanoylcarnitine. Therefore, the gene's function and the reactions it catalyzes are unrelated to the reaction involving L-carnitine and nonadecanoylcarnitine.	No
ENSG00000197119	Q8N8R3	MAR02679: eicosanoylcarnitine + L-carnitine <=> eicosanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of specific amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It functions through both counter-exchange and uniport mechanisms. However, the provided reaction involves eicosanoylcarnitine and L-carnitine, which are not substrates for the transporter encoded by ENSG00000197119. The gene does not transport carnitine nor acylcarnitines, confirming that it is unrelated to the reaction involving eicosanoylcarnitine and L-carnitine.	No
ENSG00000197119	Q8N8R3	MAR02682: eicosenoylcarnitine(7) + L-carnitine <=> eicosenoylcarnitine(7) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter primarily involved in the transport of basic amino acids like arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It functions by both counter-exchange and uniport mechanisms, specifically for mitochondrial protein synthesis and amino acid degradation. It is explicitly stated that it does not transport carnitine or acylcarnitines. In contrast, the reaction provided involves eicosenoylcarnitine and L-carnitine, which are outside the functional scope of the gene's described transport activities. Therefore, the gene does not play any role in the given reaction.	No
ENSG00000149742	Q8IVM8	MAR02685: eicosenoylcarnitine(9) + L-carnitine <=> eicosenoylcarnitine(9) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149742 encodes for a sodium-independent organic anion transporter that specifically interacts with sulfated conjugates of xenobiotics and steroid hormones like estrone 3-sulfate and dehydroepiandrosterone sulfate. It facilitates the exchange of these sulfated compounds against short-chain fatty acids. However, the reaction provided involves eicosenoylcarnitine and L-carnitine, which are not part of the substrates or products transported by the protein encoded by ENSG00000149742. Therefore, the gene does not correlate with the given reaction.	No
ENSG00000197119	Q8N8R3	MAR02685: eicosenoylcarnitine(9) + L-carnitine <=> eicosenoylcarnitine(9) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. The gene ENSG00000197119 encodes a mitochondrial transporter involved specifically in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. However, it does not transport carnitine or acylcarnitines as confirmed by the provided annotations. The reaction described involves eicosenoylcarnitine and L-carnitine, which are outside the transporter's substrate specificity, thus making the gene irrelevant to the provided reaction.	No
ENSG00000149742	Q8IVM8	MAR02688: eicosenoylcarnitine(11) + L-carnitine <=> eicosenoylcarnitine(11) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes for a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones like estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS). It is involved in the exchange of these sulfated organic components with short-chain fatty acids such as propionate, butyrate, and valerate. However, the reaction provided involves the exchange between eicosenoylcarnitine(11) and L-carnitine, which is unrelated to the substrates and functions of the gene product. Therefore, the gene's function and catalytic activities do not align with the reaction involving eicosenoylcarnitine(11) and L-carnitine.	No
ENSG00000149742	Q8IVM8	MAR02691: (8Z,11Z)-eicosadienoylcarnitine + L-carnitine <=> (8Z,11Z)-eicosadienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 is annotated as encoding a sodium-independent organic anion transporter with specificity for sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS), and it can transport short-chain fatty acids (SCFAs) like propionate, butyrate, and valerate. The reactions catalyzed by this transporter involve the exchange of sulfated organic components against SCFAs. However, the provided reaction involves (8Z,11Z)-eicosadienoylcarnitine and L-carnitine, substances not mentioned in the gene's function, thus indicating no relevance between the gene and the reaction.	No
ENSG00000197119	Q8N8R3	MAR02691: (8Z,11Z)-eicosadienoylcarnitine + L-carnitine <=> (8Z,11Z)-eicosadienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 is annotated to encode a mitochondrial transporter specific for several basic amino acids, including arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. Importantly, the annotation indicates that the gene product does not transport carnitine or acylcarnitines. The provided reaction involves the exchange of (8Z,11Z)-eicosadienoylcarnitine and L-carnitine, which are not substrates transported by the gene product. Therefore, there is no relevance between the gene and the provided reaction.	No
ENSG00000149742	Q8IVM8	MAR02695: (5Z,8Z,11Z)-eicosatrienoylcarnitine + L-carnitine <=> (5Z,8Z,11Z)-eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, and can transport statins like pravastatin. The catalyzed reactions involve the exchange of sulfated organic components against short-chain fatty acids. However, the provided reaction involves the conversion of (5Z,8Z,11Z)-eicosatrienoylcarnitine and L-carnitine, which are not sulfated conjugates or short-chain fatty acids, indicating no relevance to the gene¡¯s known transport activity.	No
ENSG00000197119	Q8N8R3	MAR02695: (5Z,8Z,11Z)-eicosatrienoylcarnitine + L-carnitine <=> (5Z,8Z,11Z)-eicosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, and it does not transport carnitine or acylcarnitines. The provided reaction involves (5Z,8Z,11Z)-eicosatrienoylcarnitine and L-carnitine, which are not substrates of the transporter encoded by this gene. Therefore, the gene is not related to the reaction.	No
ENSG00000149742	Q8IVM8	MAR02700: heneicosanoylcarnitine + L-carnitine <=> heneicosanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter with high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. It facilitates the exchange of these sulfated organic components against short-chain fatty acids at the sinusoidal membrane of hepatocytes. However, the reaction specified, heneicosanoylcarnitine + L-carnitine <=> heneicosanoylcarnitine + L-carnitine, does not involve sulfated conjugates or short-chain fatty acids and therefore is not related to the function of this gene.	No
ENSG00000197119	Q8N8R3	MAR02700: heneicosanoylcarnitine + L-carnitine <=> heneicosanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines. The reaction provided involves heneicosanoylcarnitine and L-carnitine, which are not substrates or products that the gene is known to transport, according to the given annotations and references. Therefore, the gene is not relevant to this reaction.	No

[feiranl]

LGTM! Those three genes (ENSG00000197119 ENSG00000149742 ENSG00000175003) cannot transport carnitine

[JHL-452b]

fixed by #923