diff --git a/mcs/build/profiles/unityaot.make b/mcs/build/profiles/unityaot.make
index 779c260ad8ca..060115d09cac 100644
--- a/mcs/build/profiles/unityaot.make
+++ b/mcs/build/profiles/unityaot.make
@@ -31,7 +31,6 @@ PROFILE_MCS_FLAGS = \
 	-d:UNITY \
 	-d:UNITY_AOT \
 	-d:MOBILE,MOBILE_LEGACY \
-	-d:DISABLE_COM \
 	-d:FULL_AOT_DESKTOP	\
 	-d:FULL_AOT_RUNTIME \
 	$(PLATFORM_FLAGS) \
@@ -46,4 +45,12 @@ NO_INSTALL = yes
 AOT_FRIENDLY_PROFILE = yes
 ALWAYS_AOT_BCL = yes
 MOBILE_PROFILE = yes
-NO_SRE = yes
\ No newline at end of file
+NO_SRE = yes
+
+ifeq ($(HOST_PLATFORM),macos)
+PROFILE_MCS_FLAGS += -d:DISABLE_COM
+endif
+
+ifeq ($(HOST_PLATFORM),linux)
+PROFILE_MCS_FLAGS += -d:DISABLE_COM
+endif
diff --git a/mcs/build/profiles/unityjit.make b/mcs/build/profiles/unityjit.make
index 5133e933e1be..94495c6d708b 100644
--- a/mcs/build/profiles/unityjit.make
+++ b/mcs/build/profiles/unityjit.make
@@ -11,7 +11,7 @@ profile-check:
 	@:
 
 DEFAULT_REFERENCES = mscorlib
-PROFILE_MCS_FLAGS = -d:NET_4_0 -d:NET_4_5 -d:NET_4_6 -d:MONO -d:UNITY_JIT -d:UNITY -d:WIN_PLATFORM -d:DISABLE_COM -nowarn:1699 -nostdlib $(PLATFORM_DEBUG_FLAGS)
+PROFILE_MCS_FLAGS = -d:NET_4_0 -d:NET_4_5 -d:NET_4_6 -d:MONO -d:UNITY_JIT -d:UNITY -d:WIN_PLATFORM -nowarn:1699 -nostdlib $(PLATFORM_DEBUG_FLAGS)
 API_BIN_PROFILE = v4.7.1
 
 FRAMEWORK_VERSION = 4.5
@@ -20,8 +20,10 @@ XBUILD_VERSION = 4.0
 ifeq ($(HOST_PLATFORM),macos)
 MONO_FEATURE_APPLETLS=1
 ENABLE_GSS=1
+PROFILE_MCS_FLAGS += -d:DISABLE_COM
 endif
 
 ifeq ($(HOST_PLATFORM),linux)
 ENABLE_GSS=1
+PROFILE_MCS_FLAGS += -d:DISABLE_COM
 endif
diff --git a/mcs/class/corlib/System.Runtime.InteropServices/Marshal.cs b/mcs/class/corlib/System.Runtime.InteropServices/Marshal.cs
index 4e1a4982dcf4..29d55eeb5530 100644
--- a/mcs/class/corlib/System.Runtime.InteropServices/Marshal.cs
+++ b/mcs/class/corlib/System.Runtime.InteropServices/Marshal.cs
@@ -856,7 +856,7 @@ public static object GetUniqueObjectForIUnknown (IntPtr unknown)
 			throw new PlatformNotSupportedException ();
 		}
 
-#if (!MOBILE && !UNITY) || UNITY_AOT
+#if (!MOBILE && !DISABLE_COM) || (UNITY_AOT && !DISABLE_COM)
 		[MethodImplAttribute (MethodImplOptions.InternalCall)]
 		public extern static bool IsComObject (object o);
 #else