diff --git a/src/winetricks b/src/winetricks
index 3df7d51fa..4e9b8804d 100755
--- a/src/winetricks
+++ b/src/winetricks
@@ -9656,6 +9656,10 @@ load_dotnet40()
     # Avoid a popup on WINEPREFIX updates, see https://bugs.winehq.org/show_bug.cgi?id=41727#c5
     "${WINE}" reg add "HKLM\\Software\\Microsoft\\.NETFramework" /v OnlyUseLatestCLR /t REG_DWORD /d 0001 /f
 
+    if [ "${W_ARCH}" = "win64" ]; then
+        "${WINE}" reg add "HKLM\\Software\\Wow6432Node\\.NETFramework" /v OnlyUseLatestCLR /t REG_DWORD /d 0001 /f
+    fi
+
     # See https://bugs.winehq.org/show_bug.cgi?id=47277#c9
     case "${LANG}" in
         C|en_US.UTF-8*) ;;
@@ -9759,6 +9763,10 @@ load_dotnet45()
     # Avoid a popup on WINEPREFIX updates, see https://bugs.winehq.org/show_bug.cgi?id=41727#c5
     "${WINE}" reg add "HKLM\\Software\\Microsoft\\.NETFramework" /v OnlyUseLatestCLR /t REG_DWORD /d 0001 /f
 
+    if [ "${W_ARCH}" = "win64" ]; then
+        "${WINE}" reg add "HKLM\\Software\\Wow6432Node\\.NETFramework" /v OnlyUseLatestCLR /t REG_DWORD /d 0001 /f
+    fi
+
     w_warn "Setting Windows version to 2003, otherwise applications using .NET 4.5 will subtly fail"
     w_set_winver win2k3