diff --git a/lib/experimental/script-modules.php b/lib/experimental/script-modules.php
index 5a14e1418ed6d..a113df02b9d75 100644
--- a/lib/experimental/script-modules.php
+++ b/lib/experimental/script-modules.php
@@ -200,3 +200,30 @@ function gutenberg_dequeue_module( $module_identifier ) {
 	_deprecated_function( __FUNCTION__, 'Gutenberg 17.6.0', 'wp_dequeue_script_module' );
 	wp_script_modules()->dequeue( $module_identifier );
 }
+
+/**
+ * Registers Gutenberg Script Modules.
+ *
+ * @since 19.3
+ */
+function gutenberg_register_script_modules() {
+	// When in production, use the plugin's version as the default asset version;
+	// else (for development or test) default to use the current time.
+	$default_version = defined( 'GUTENBERG_VERSION' ) && ! SCRIPT_DEBUG ? GUTENBERG_VERSION : time();
+
+	wp_deregister_script_module( '@wordpress/a11y' );
+	wp_register_script_module(
+		'@wordpress/a11y',
+		gutenberg_url( 'build-module/a11y/index.min.js' ),
+		array(),
+		$default_version
+	);
+	add_filter(
+		'script_module_data_@wordpress/a11y',
+		function ( $data ) {
+			$data['i18n'] = array( 'Notifications' => __( 'Notifications', 'default' ) );
+			return $data;
+		}
+	);
+}
+add_action( 'init', 'gutenberg_register_script_modules' );
diff --git a/packages/a11y/README.md b/packages/a11y/README.md
index 0f40d9edd010e..755396d2bb8f0 100644
--- a/packages/a11y/README.md
+++ b/packages/a11y/README.md
@@ -39,7 +39,7 @@ speak( 'The message you want to send to the ARIA live region', 'assertive' );
 _Parameters_
 
 -   _message_ `string`: The message to be announced by assistive technologies.
--   _ariaLive_ `[string]`: The politeness level for aria-live; default: 'polite'.
+-   _ariaLive_ `['polite'|'assertive']`: The politeness level for aria-live; default: 'polite'.
 
 <!-- END TOKEN(Autogenerated API docs) -->
 
diff --git a/packages/a11y/package.json b/packages/a11y/package.json
index 88123b3c6c712..327d6b9ff0716 100644
--- a/packages/a11y/package.json
+++ b/packages/a11y/package.json
@@ -28,6 +28,7 @@
 	"module": "build-module/index.js",
 	"react-native": "src/index",
 	"types": "build-types",
+	"wpScriptModuleExports": "./build-module/module/index.js",
 	"dependencies": {
 		"@babel/runtime": "^7.16.0",
 		"@wordpress/dom-ready": "file:../dom-ready",
diff --git a/packages/a11y/src/index.js b/packages/a11y/src/index.js
index 957c76500c434..59e93da780bd8 100644
--- a/packages/a11y/src/index.js
+++ b/packages/a11y/src/index.js
@@ -2,87 +2,20 @@
  * WordPress dependencies
  */
 import domReady from '@wordpress/dom-ready';
+import { __ } from '@wordpress/i18n';
 
 /**
  * Internal dependencies
  */
-import addIntroText from './add-intro-text';
-import addContainer from './add-container';
-import clear from './clear';
-import filterMessage from './filter-message';
+import { makeSetupFunction } from './shared/index';
+export { speak } from './shared/index';
 
 /**
  * Create the live regions.
  */
-export function setup() {
-	const introText = document.getElementById( 'a11y-speak-intro-text' );
-	const containerAssertive = document.getElementById(
-		'a11y-speak-assertive'
-	);
-	const containerPolite = document.getElementById( 'a11y-speak-polite' );
-
-	if ( introText === null ) {
-		addIntroText();
-	}
-
-	if ( containerAssertive === null ) {
-		addContainer( 'assertive' );
-	}
-
-	if ( containerPolite === null ) {
-		addContainer( 'polite' );
-	}
-}
+export const setup = makeSetupFunction( __( 'Notifications' ) );
 
 /**
  * Run setup on domReady.
  */
 domReady( setup );
-
-/**
- * Allows you to easily announce dynamic interface updates to screen readers using ARIA live regions.
- * This module is inspired by the `speak` function in `wp-a11y.js`.
- *
- * @param {string} message    The message to be announced by assistive technologies.
- * @param {string} [ariaLive] The politeness level for aria-live; default: 'polite'.
- *
- * @example
- * ```js
- * import { speak } from '@wordpress/a11y';
- *
- * // For polite messages that shouldn't interrupt what screen readers are currently announcing.
- * speak( 'The message you want to send to the ARIA live region' );
- *
- * // For assertive messages that should interrupt what screen readers are currently announcing.
- * speak( 'The message you want to send to the ARIA live region', 'assertive' );
- * ```
- */
-export function speak( message, ariaLive ) {
-	/*
-	 * Clear previous messages to allow repeated strings being read out and hide
-	 * the explanatory text from assistive technologies.
-	 */
-	clear();
-
-	message = filterMessage( message );
-
-	const introText = document.getElementById( 'a11y-speak-intro-text' );
-	const containerAssertive = document.getElementById(
-		'a11y-speak-assertive'
-	);
-	const containerPolite = document.getElementById( 'a11y-speak-polite' );
-
-	if ( containerAssertive && ariaLive === 'assertive' ) {
-		containerAssertive.textContent = message;
-	} else if ( containerPolite ) {
-		containerPolite.textContent = message;
-	}
-
-	/*
-	 * Make the explanatory text available to assistive technologies by removing
-	 * the 'hidden' HTML attribute.
-	 */
-	if ( introText ) {
-		introText.removeAttribute( 'hidden' );
-	}
-}
diff --git a/packages/a11y/src/index.native.js b/packages/a11y/src/index.native.js
index f6f53b6343adb..e17597a8b2747 100644
--- a/packages/a11y/src/index.native.js
+++ b/packages/a11y/src/index.native.js
@@ -1,7 +1,7 @@
 /**
  * Internal dependencies
  */
-import filterMessage from './filter-message';
+import filterMessage from './shared/filter-message';
 
 /**
  * Update the ARIA live notification area text node.
diff --git a/packages/a11y/src/module/index.ts b/packages/a11y/src/module/index.ts
new file mode 100644
index 0000000000000..a2c87f397f487
--- /dev/null
+++ b/packages/a11y/src/module/index.ts
@@ -0,0 +1,25 @@
+/**
+ * Internal dependencies
+ */
+import { makeSetupFunction } from '../shared/index';
+export { speak } from '../shared/index';
+
+// Without an i18n Script Module, "Notifications" (the only localized text used in this module)
+// will be translated on the server and provided as script-module data.
+let notificationsText = 'Notifications';
+try {
+	const textContent = document.getElementById(
+		'wp-script-module-data-@wordpress/a11y'
+	)?.textContent;
+	if ( textContent ) {
+		const parsed = JSON.parse( textContent );
+		notificationsText = parsed?.i18n?.Notifications ?? notificationsText;
+	}
+} catch {}
+
+/**
+ * Create the live regions.
+ */
+export const setup = makeSetupFunction( notificationsText );
+
+setup();
diff --git a/packages/a11y/src/add-container.js b/packages/a11y/src/shared/add-container.js
similarity index 100%
rename from packages/a11y/src/add-container.js
rename to packages/a11y/src/shared/add-container.js
diff --git a/packages/a11y/src/add-intro-text.js b/packages/a11y/src/shared/add-intro-text.ts
similarity index 83%
rename from packages/a11y/src/add-intro-text.js
rename to packages/a11y/src/shared/add-intro-text.ts
index 2bcf453ec44c8..6bd97c887664d 100644
--- a/packages/a11y/src/add-intro-text.js
+++ b/packages/a11y/src/shared/add-intro-text.ts
@@ -1,22 +1,18 @@
-/**
- * WordPress dependencies
- */
-import { __ } from '@wordpress/i18n';
-
 /**
  * Build the explanatory text to be placed before the aria live regions.
  *
  * This text is initially hidden from assistive technologies by using a `hidden`
  * HTML attribute which is then removed once a message fills the aria-live regions.
  *
+ * @param {string} introTextContent The translated intro text content.
  * @return {HTMLParagraphElement} The explanatory text HTML element.
  */
-export default function addIntroText() {
+export default function addIntroText( introTextContent: string ) {
 	const introText = document.createElement( 'p' );
 
 	introText.id = 'a11y-speak-intro-text';
 	introText.className = 'a11y-speak-intro-text';
-	introText.textContent = __( 'Notifications' );
+	introText.textContent = introTextContent;
 
 	introText.setAttribute(
 		'style',
diff --git a/packages/a11y/src/clear.js b/packages/a11y/src/shared/clear.js
similarity index 100%
rename from packages/a11y/src/clear.js
rename to packages/a11y/src/shared/clear.js
diff --git a/packages/a11y/src/filter-message.js b/packages/a11y/src/shared/filter-message.js
similarity index 100%
rename from packages/a11y/src/filter-message.js
rename to packages/a11y/src/shared/filter-message.js
diff --git a/packages/a11y/src/shared/index.js b/packages/a11y/src/shared/index.js
new file mode 100644
index 0000000000000..a05f891f42856
--- /dev/null
+++ b/packages/a11y/src/shared/index.js
@@ -0,0 +1,81 @@
+/**
+ * Internal dependencies
+ */
+import addContainer from './add-container';
+import addIntroText from './add-intro-text';
+import clear from './clear';
+import filterMessage from './filter-message';
+
+/**
+ * Create the live regions.
+ * @param {string} introTextContent The intro text content.
+ */
+export function makeSetupFunction( introTextContent ) {
+	return function setup() {
+		const introText = document.getElementById( 'a11y-speak-intro-text' );
+		const containerAssertive = document.getElementById(
+			'a11y-speak-assertive'
+		);
+		const containerPolite = document.getElementById( 'a11y-speak-polite' );
+
+		if ( introText === null ) {
+			addIntroText( introTextContent );
+		}
+
+		if ( containerAssertive === null ) {
+			addContainer( 'assertive' );
+		}
+
+		if ( containerPolite === null ) {
+			addContainer( 'polite' );
+		}
+	};
+}
+
+/**
+ * Allows you to easily announce dynamic interface updates to screen readers using ARIA live regions.
+ * This module is inspired by the `speak` function in `wp-a11y.js`.
+ *
+ * @param {string}               message    The message to be announced by assistive technologies.
+ * @param {'polite'|'assertive'} [ariaLive] The politeness level for aria-live; default: 'polite'.
+ *
+ * @example
+ * ```js
+ * import { speak } from '@wordpress/a11y';
+ *
+ * // For polite messages that shouldn't interrupt what screen readers are currently announcing.
+ * speak( 'The message you want to send to the ARIA live region' );
+ *
+ * // For assertive messages that should interrupt what screen readers are currently announcing.
+ * speak( 'The message you want to send to the ARIA live region', 'assertive' );
+ * ```
+ */
+export function speak( message, ariaLive ) {
+	/*
+	 * Clear previous messages to allow repeated strings being read out and hide
+	 * the explanatory text from assistive technologies.
+	 */
+	clear();
+
+	message = filterMessage( message );
+
+	const introText = document.getElementById( 'a11y-speak-intro-text' );
+	const containerAssertive = document.getElementById(
+		'a11y-speak-assertive'
+	);
+	const containerPolite = document.getElementById( 'a11y-speak-polite' );
+
+	if ( containerAssertive && ariaLive === 'assertive' ) {
+		containerAssertive.textContent = message;
+	} else if ( containerPolite ) {
+		containerPolite.textContent = message;
+	}
+
+	/*
+	 * Make the explanatory text available to assistive technologies by removing
+	 * the 'hidden' HTML attribute.
+	 */
+	if ( introText ) {
+		introText.removeAttribute( 'hidden' );
+	}
+}
diff --git a/packages/a11y/src/test/add-container.test.js b/packages/a11y/src/shared/test/add-container.test.js
similarity index 100%
rename from packages/a11y/src/test/add-container.test.js
rename to packages/a11y/src/shared/test/add-container.test.js
diff --git a/packages/a11y/src/test/clear.test.js b/packages/a11y/src/shared/test/clear.test.js
similarity index 100%
rename from packages/a11y/src/test/clear.test.js
rename to packages/a11y/src/shared/test/clear.test.js
diff --git a/packages/a11y/src/test/filter-message.test.js b/packages/a11y/src/shared/test/filter-message.test.js
similarity index 100%
rename from packages/a11y/src/test/filter-message.test.js
rename to packages/a11y/src/shared/test/filter-message.test.js
diff --git a/packages/a11y/src/test/index.test.js b/packages/a11y/src/test/index.test.js
index 4815baa220504..0f6b9d0bd572e 100644
--- a/packages/a11y/src/test/index.test.js
+++ b/packages/a11y/src/test/index.test.js
@@ -7,10 +7,10 @@ import domReady from '@wordpress/dom-ready';
  * Internal dependencies
  */
 import { setup, speak } from '../';
-import clear from '../clear';
-import filterMessage from '../filter-message';
+import clear from '../shared/clear';
+import filterMessage from '../shared/filter-message';
 
-jest.mock( '../clear', () => {
+jest.mock( '../shared/clear', () => {
 	return jest.fn();
 } );
 jest.mock( '@wordpress/dom-ready', () => {
@@ -18,7 +18,7 @@ jest.mock( '@wordpress/dom-ready', () => {
 		callback();
 	} );
 } );
-jest.mock( '../filter-message', () => {
+jest.mock( '../shared/filter-message', () => {
 	return jest.fn( ( message ) => {
 		return message;
 	} );
diff --git a/packages/dependency-extraction-webpack-plugin/lib/util.js b/packages/dependency-extraction-webpack-plugin/lib/util.js
index fcc6e5a0ed173..cc99986024476 100644
--- a/packages/dependency-extraction-webpack-plugin/lib/util.js
+++ b/packages/dependency-extraction-webpack-plugin/lib/util.js
@@ -90,9 +90,10 @@ function defaultRequestToExternalModule( request ) {
 		return `module ${ request }`;
 	}
 
-	if ( request === '@wordpress/interactivity-router' ) {
-		// Assumes this is usually going to be used as a dynamic import.
-		return `import ${ request }`;
+	switch ( request ) {
+		case '@wordpress/interactivity-router':
+		case '@wordpress/a11y':
+			return `import ${ request }`;
 	}
 
 	const isWordPressScript = Boolean( defaultRequestToExternal( request ) );