diff --git a/packages/block-editor/src/components/writing-flow/use-home-end.js b/packages/block-editor/src/components/writing-flow/use-home-end.js
index a3641dcccc4967..ce8d6a1b7a2369 100644
--- a/packages/block-editor/src/components/writing-flow/use-home-end.js
+++ b/packages/block-editor/src/components/writing-flow/use-home-end.js
@@ -12,10 +12,16 @@ import { getSelectionEditableElement } from '../../utils/dom';
 import { store as blockEditorStore } from '../../store';
 
 /**
- * While the wrapper is the contentEditable editing host (a selected block
- * supports `editableRoot`), browsers don't perform the default caret
- * movement for Home and End. Perform the equivalent movement with
- * `Selection.modify()`.
+ * Moves the caret to the start or end of the visual line for Home and End
+ * with `Selection.modify()`, because the browser's default caret movement
+ * cannot be relied on in two cases:
+ *
+ * - While the wrapper is the contentEditable editing host (a selected block
+ *   supports `editableRoot`), browsers don't perform the default caret
+ *   movement for Home and End.
+ * - Chromium on macOS maps Home and End to scroll commands, so it never
+ *   moves the caret in editable content on that platform, including nested
+ *   editable elements like the tab labels in the tab-list block.
  */
 export default function useHomeEnd() {
 	const { hasMultiSelection } = useSelect( blockEditorStore );
@@ -33,11 +39,13 @@ export default function useHomeEnd() {
 				return;
 			}
 
-			if (
-				node.contentEditable !== 'true' ||
-				node.ownerDocument.activeElement !== node ||
-				hasMultiSelection()
-			) {
+			// Only handle keys pressed in editable content, in both of the
+			// cases mentioned above: `event.target` is the focused element,
+			// and `isContentEditable` is true both for the wrapper as the
+			// editing host and for a nested editable element like a tab label.
+			// Anything else that takes focus like inputs and textareas keep
+			// default behavior.
+			if ( ! event.target.isContentEditable || hasMultiSelection() ) {
 				return;
 			}
 
diff --git a/test/e2e/specs/editor/blocks/tabs.spec.js b/test/e2e/specs/editor/blocks/tabs.spec.js
index 5935b98915fb16..48ee010574a013 100644
--- a/test/e2e/specs/editor/blocks/tabs.spec.js
+++ b/test/e2e/specs/editor/blocks/tabs.spec.js
@@ -164,8 +164,13 @@ test.describe( 'Tabs', () => {
 			).toBeFocused();
 
 			// The new tab's panel is the active one and is visible.
+			// Use `exact: true` to avoid matching the parent 'Block: Tab Panels' name.
+			// Use `includeHidden: true` to check the number of hidden panels. getByRole()
+			// only returns visible elements by default.
 			const panels = editor.canvas.getByRole( 'document', {
 				name: 'Block: Tab Panel',
+				exact: true,
+				includeHidden: true,
 			} );
 			await expect( panels ).toHaveCount( 3 );
 			await expect( panels.nth( 2 ) ).toBeVisible();