diff --git a/crates/uv-distribution/src/pyproject.rs b/crates/uv-distribution/src/pyproject.rs
index 258d1529be2e..fb2589285066 100644
--- a/crates/uv-distribution/src/pyproject.rs
+++ b/crates/uv-distribution/src/pyproject.rs
@@ -83,6 +83,14 @@ pub struct ToolUv {
         )
     )]
     pub dev_dependencies: Option<Vec<pep508_rs::Requirement<VerbatimParsedUrl>>>,
+    #[cfg_attr(
+        feature = "schemars",
+        schemars(
+            with = "Option<Vec<String>>",
+            description = "PEP 508 style requirements, e.g. `flask==3.0.0`, or `black @ https://...`."
+        )
+    )]
+    pub override_dependencies: Option<Vec<pep508_rs::Requirement<VerbatimParsedUrl>>>,
 }
 
 #[derive(Serialize, Deserialize, Default, Debug, Clone, PartialEq, Eq)]
diff --git a/crates/uv/src/commands/project/lock.rs b/crates/uv/src/commands/project/lock.rs
index 4cb0f62d4366..b1a506473ba4 100644
--- a/crates/uv/src/commands/project/lock.rs
+++ b/crates/uv/src/commands/project/lock.rs
@@ -4,6 +4,7 @@ use anstream::eprint;
 
 use distribution_types::{IndexLocations, UnresolvedRequirementSpecification};
 use install_wheel_rs::linker::LinkMode;
+use pep508_rs::RequirementOrigin;
 use uv_cache::Cache;
 use uv_client::{Connectivity, FlatIndexClient, RegistryClientBuilder};
 use uv_configuration::{
@@ -124,7 +125,30 @@ pub(super) async fn do_lock(
         .map(UnresolvedRequirementSpecification::from)
         .collect();
     let constraints = vec![];
-    let overrides = vec![];
+
+    let mut overrides: Vec<UnresolvedRequirementSpecification> = vec![];
+    for workspace_package in workspace.packages().values() {
+        if workspace_package.root() == workspace.root() {
+            if let Some(override_dependencies) = workspace_package
+                .pyproject_toml()
+                .tool
+                .as_ref()
+                .and_then(|tool| tool.uv.as_ref())
+                .and_then(|uv| uv.override_dependencies.as_ref())
+            {
+                for override_dependency in override_dependencies {
+                    let req = pypi_types::Requirement::from(
+                        override_dependency
+                            .clone()
+                            .with_origin(RequirementOrigin::Workspace),
+                    );
+                    overrides.push(UnresolvedRequirementSpecification::from(req));
+                }
+            }
+            break;
+        }
+    }
+
     let dev = vec![DEV_DEPENDENCIES.clone()];
 
     let source_trees = vec![];
diff --git a/crates/uv/tests/lock.rs b/crates/uv/tests/lock.rs
index 9abc58879eb5..5507f718da56 100644
--- a/crates/uv/tests/lock.rs
+++ b/crates/uv/tests/lock.rs
@@ -583,6 +583,56 @@ fn lock_project_extra() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn lock_project_with_overrides() -> Result<()> {
+    let context = TestContext::new("3.12");
+
+    let pyproject_toml = context.temp_dir.child("pyproject.toml");
+    pyproject_toml.write_str(
+        r#"
+        [project]
+        name = "project"
+        version = "0.1.0"
+        requires-python = ">=3.12"
+        dependencies = ["flask==3.0.0"]
+
+        [tool.uv]
+        override-dependencies = ["werkzeug==2.3.8"]
+        "#,
+    )?;
+
+    uv_snapshot!(context.filters(), context.lock(), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    warning: `uv lock` is experimental and may change without warning.
+    Resolved 9 packages in [TIME]
+    "###);
+
+    // Install the base dependencies from the lockfile.
+    uv_snapshot!(context.filters(), context.sync(), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    warning: `uv sync` is experimental and may change without warning.
+    Prepared 8 packages in [TIME]
+    Installed 8 packages in [TIME]
+     + blinker==1.7.0
+     + click==8.1.7
+     + flask==3.0.0
+     + itsdangerous==2.1.2
+     + jinja2==3.1.3
+     + markupsafe==2.1.5
+     + project==0.1.0 (from file://[TEMP_DIR]/)
+     + werkzeug==2.3.8
+    "###);
+
+    Ok(())
+}
 /// Lock a project with a dependency that has an extra.
 #[test]
 fn lock_dependency_extra() -> Result<()> {