Add variant QA flags to VA

Author: phildarnowsky-broad

graphql-api/src/graphql/resolvers/va.spec.ts

@@ -67,6 +67,7 @@ describe('resolveVACohortAlleleFrequency', () => {
     exome: exomeEsDocument,
     joint: { fafmax: { faf95_max: 0.234, faf95_max_gen_anc: 'amr' } },
     coverage: { exome: { mean: 0.345, over_20: 0.456 } },
+    flags: ['monoallelic', 'lcr', 'lc_lof', 'lof_flag'],
   }
 
   test('parses a single CohortAlleleFrequency correctly', async () => {
@@ -98,10 +99,10 @@ describe('resolveVACohortAlleleFrequency', () => {
           meanDepth: 0.345,
           fractionCoverage20x: 0.456,
           qcFilters: ['AC0'],
-          monoallelic: null,
-          lowComplexityRegion: null,
-          lowConfidenceLossOfFunctionError: null,
-          lossOfFunctionWarning: null,
+          monoallelic: true,
+          lowComplexityRegion: true,
+          lowConfidenceLossOfFunctionError: true,
+          lossOfFunctionWarning: true,
           heterozygousSkewedAlleleCount: null,
         },
       },

graphql-api/src/graphql/resolvers/va.ts

@@ -389,10 +389,10 @@ export const resolveVACohortAlleleFrequencies = async (
     meanDepth: coverage && coverage.mean ? coverage.mean : null,
     fractionCoverage20x: coverage && coverage.over_20 ? coverage.over_20 : null,
     qcFilters: frequencies.filters,
-    monoallelic: null,
-    lowComplexityRegion: null,
-    lowConfidenceLossOfFunctionError: null,
-    lossOfFunctionWarning: null,
+    monoallelic: obj.flags.includes('monoallelic'),
+    lowComplexityRegion: obj.flags.includes('lcr'),
+    lowConfidenceLossOfFunctionError: obj.flags.includes('lc_lof'),
+    lossOfFunctionWarning: obj.flags.includes('lof_flag'),
     heterozygousSkewedAlleleCount: null,
   }