diff --git a/CHANGELOG.md b/CHANGELOG.md
index 2595f3f0..b816abff 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,8 @@
 - Move to WebGL rendering for regions
 - Refactor completely the region tab to better handle large number of items
 - Allow import of regions from multiple GeoJSON files
+- Add support for pbf region files
+- Add drag-and-drop opening of GeoJSON files
 - Add histogram button for analyzing individual regions
 - Make regions work in collection mode and with multiple image layers
 - Add marker outline and fill options in Advanced options
diff --git a/tissuumaps/gui.py b/tissuumaps/gui.py
index 4f301f0d..4c3a1fba 100644
--- a/tissuumaps/gui.py
+++ b/tissuumaps/gui.py
@@ -530,6 +530,8 @@ def dropEvent(self, event):
                     self.openImagePath(link)
                 elif file_extension == ".csv":
                     self.page().runJavaScript(f'flask.standalone.addCSV("{link}");')
+                elif file_extension in [".json", ".geojson", ".pbf"]:
+                    self.page().runJavaScript(f'flask.standalone.addGeoJSON("{link}");')
                 else:
                     self.page().runJavaScript(f'flask.standalone.addLayer("{link}");')
             # self.emit(SIGNAL("dropped"), links)
@@ -714,6 +716,18 @@ def openImagePath(self, folderpath):
             )
             self.page().runJavaScript(f'flask.standalone.addCSV("{folderpath}");')
             return True
+        elif file_extension in [".json", ".geojson", ".pbf"]:
+            logging.debug(
+                " ".join(
+                    [
+                        "Opening json:",
+                        str(self.app.basedir),
+                        str(self.location + imgPath),
+                    ]
+                )
+            )
+            self.page().runJavaScript(f'flask.standalone.addGeoJSON("{folderpath}");')
+            return True
         logging.debug(
             " ".join(
                 [
@@ -775,6 +789,39 @@ def addCSV(self, path, csvpath):
         }
         return returnDict
 
+    @Slot(str, str, result="QJsonObject")
+    def addGeoJSON(self, path, geoJSONpath):
+        if geoJSONpath == "":
+            geoJSONpath = QFileDialog.getOpenFileName(self, "Select a File")[0]
+        if not geoJSONpath:
+            returnDict = {"geoJSONPath": None}
+            return returnDict
+        parts = Path(geoJSONpath).parts
+        if parts[0] == "https:":
+            imgPath = parts[-1]
+            relativePath = "/".join(parts[:-1])
+
+        else:
+            if self.app.basedir != parts[0]:
+                if not self.app.basedir == os.path.abspath(
+                    self.app.config["SLIDE_DIR"]
+                ):
+                    QMessageBox.warning(
+                        self, "Error", "All files must be in the same drive."
+                    )
+                    returnDict = {"geoJSONPath": None}
+                    return returnDict
+                else:
+                    self.app.basedir = parts[0]
+            imgPath = os.path.join(*parts[1:])
+
+            path = os.path.abspath(os.path.join(self.app.basedir, path))
+            imgPath = os.path.abspath(os.path.join(self.app.basedir, imgPath))
+
+            relativePath = os.path.relpath(os.path.dirname(imgPath), path)
+        returnDict = {"geoJSONPath": relativePath + "/" + os.path.basename(imgPath)}
+        return returnDict
+
     @Slot(str, str, result="QJsonObject")
     def addLayer(self, path, layerpath):
         if layerpath == "":
diff --git a/tissuumaps/static/js/flask.js b/tissuumaps/static/js/flask.js
index 33f9d05c..8b8b45be 100644
--- a/tissuumaps/static/js/flask.js
+++ b/tissuumaps/static/js/flask.js
@@ -94,6 +94,17 @@ flask.standalone.init = function () {
     }, true);
 };
 
+flask.standalone.addGeoJSON = function (filename) {
+    const queryString = window.location.search;
+    const urlParams = new URLSearchParams(queryString);
+    const path = urlParams.get('path')
+    flask.standalone.backend.addGeoJSON(path, filename, function(geoJSONJSON) {
+        if (geoJSONJSON["geoJSONPath"]!=null) {
+            regionUtils.JSONToRegions(geoJSONJSON["geoJSONPath"]);
+        }
+    });
+}
+
 flask.standalone.addCSV = function (filename) {
     const queryString = window.location.search;
     const urlParams = new URLSearchParams(queryString);
diff --git a/tissuumaps/views.py b/tissuumaps/views.py
index 24e30b45..8497b7a6 100644
--- a/tissuumaps/views.py
+++ b/tissuumaps/views.py
@@ -655,10 +655,10 @@ def csvFile(completePath):
         abort(404)
 
 
-@app.route("/<path:completePath>.json")
+@app.route("/<path:completePath>.<any(json, geojson, pbf):ext>")
 @requires_auth
-def jsonFile(completePath):
-    completePath = os.path.join(app.basedir, completePath + ".json")
+def jsonFile(completePath, ext):
+    completePath = os.path.join(app.basedir, completePath + "." + ext)
     directory = os.path.dirname(completePath)
     filename = os.path.basename(completePath)
     if os.path.isfile(completePath):