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I recommend trying metacell construction, using SEACell or SuperCell or some other tools. And then you would get only hundreds or thousands of cell, which can be easily run on a laptop and extremely fast (1000 cell, ~1min). Metacell processing should not bias any biological conclusion on the cell cluster level, which is the interest of most downstream analysis.
How to speed up, this tool is very slow to use . My configuration is HF 2.5HZ 108 cores, 186G RAM, still very slow!
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