diff --git a/CHANGES.rst b/CHANGES.rst
index 8df29b931..8bd04e26e 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -18,6 +18,12 @@ Fixes:
 ------
 - Fix missing Node.js requirement in built Docker image in order to evaluate definitions that employ
   `CWL` ``InlineJavascriptRequirement``, such as ``valueFrom`` employed for numeric ``Enum`` input type validation.
+- Fix ``processes.wps_package.WpsPackage.make_inputs`` unable to parse multi-type `CWL` definitions due parsing
+  as single-type element with ``parse_cwl_array_type``. Function ``get_cwl_io_type`` is used instead to resolve any
+  `CWL` type combination properly.
+- Fix ``get_cwl_io_type`` function that would modify the I/O definition passed as argument, which could lead to failing
+  `CWL` ``class`` reference resolutions later on due to different ``type`` with ``org.w3id.cwl.cwl`` prefix simplified
+  before ``cwltool`` had the chance to resolve them.
 
 .. _changes_4.31.0:
 
diff --git a/tests/processes/test_convert.py b/tests/processes/test_convert.py
index 44e31bf39..0f8f1601a 100644
--- a/tests/processes/test_convert.py
+++ b/tests/processes/test_convert.py
@@ -1,6 +1,8 @@
 """
 Unit tests of functions within :mod:`weaver.processes.convert`.
 """
+import copy
+
 # pylint: disable=R1729  # ignore non-generator representation employed for displaying test log results
 
 import json
@@ -708,7 +710,7 @@ def test_cwl2wps_io_record_format():
 
 
 @pytest.mark.parametrize(
-    "io_type, io_info",
+    ["io_type", "io_info"],
     [
         (WPS_LITERAL, {"type": WPS_LITERAL}),
         (WPS_COMPLEX, {"type": WPS_COMPLEX}),
@@ -727,28 +729,64 @@ def test_get_io_type_category(io_type, io_info):
     assert get_io_type_category(io_info) == io_type, f"Testing: {io_info}"
 
 
-@pytest.mark.parametrize("io_info, io_def", [
-    ({"type": "string"},
-     CWLIODefinition(type="string")),
-    ({"type": "int"},
-     CWLIODefinition(type="int")),
-    ({"type": "float"},
-     CWLIODefinition(type="float")),
-    ({"type": {"type": "enum", "symbols": ["a", "b", "c"]}},
-     CWLIODefinition(type="string", enum=True, symbols=["a", "b", "c"], mode=MODE.SIMPLE)),
-    ({"type": {"type": "array", "items": "string"}},
-     CWLIODefinition(type="string", array=True, min_occurs=1, max_occurs=PACKAGE_ARRAY_MAX_SIZE)),
-    ({"type": ["null", "string"]},
-     CWLIODefinition(type="string", null=True, min_occurs=0)),
-    ({"type": "string?"},
-     CWLIODefinition(type="string", null=True, min_occurs=0)),
-])
+@pytest.mark.parametrize(
+    ["io_info", "io_def"],
+    [
+        ({"type": "string"},
+         CWLIODefinition(type="string")),
+        ({"type": "int"},
+         CWLIODefinition(type="int")),
+        ({"type": "float"},
+         CWLIODefinition(type="float")),
+        ({"type": {"type": "enum", "symbols": ["a", "b", "c"]}},
+         CWLIODefinition(type="string", enum=True, symbols=["a", "b", "c"], mode=MODE.SIMPLE)),
+        ({"type": {"type": "array", "items": "string"}},
+         CWLIODefinition(type="string", array=True, min_occurs=1, max_occurs=PACKAGE_ARRAY_MAX_SIZE)),
+        ({"type": ["null", "string"]},
+         CWLIODefinition(type="string", null=True, min_occurs=0)),
+        ({"type": "string?"},
+         CWLIODefinition(type="string", null=True, min_occurs=0)),
+    ]
+)
 def test_get_cwl_io_type(io_info, io_def):
     io_def.name = io_info["name"] = "test"
     io_res = get_cwl_io_type(io_info)
     assert io_res == io_def
 
 
+@pytest.mark.parametrize(
+    ["io_info", "io_def"],
+    [
+        (
+            {
+                "name": "test",
+                "type": "org.w3id.cwl.cwl.File",
+                "format": "https://www.iana.org/assignments/media-types/application/json",
+                "location": "/tmp/random.json",
+            },
+            CWLIODefinition(name="test", type="File")
+        )
+    ]
+)
+def test_get_cwl_io_type_unmodified(io_info, io_def):
+    """
+    Ensure that the input I/O details do not cause a side effect modification of the data when parsing the definition.
+
+    When :func:`get_cwl_io_type` was called with a definition containing ``type: org.w3id.cwl.cwl.File``, the resulting
+    parsing caused the input information to be overriden by ``type: File``. Although they are essentially equivalent
+    once resolved, this modification performed before :mod:`cwltool` had the time to parse the definition made it
+    incorrectly resolve ``class: File``, which in turn, caused :class:`cwltool.pathmapper.PathMapper` to be missing
+    the mapped ``location`` of provided inputs, leading to full :term:`CWL` execution failure.
+
+    .. seealso::
+        - https://github.com/crim-ca/weaver/pull/546
+    """
+    io_copy = copy.deepcopy(io_info)
+    io_res = get_cwl_io_type(io_info)
+    assert io_res == io_def
+    assert io_info == io_copy, "Argument I/O information should not be modified from parsing."
+
+
 def test_parse_cwl_array_type_explicit_invalid_item():
     io_info = {
         "name": "test",
diff --git a/weaver/processes/convert.py b/weaver/processes/convert.py
index d79af1e5f..9016e0cb0 100644
--- a/weaver/processes/convert.py
+++ b/weaver/processes/convert.py
@@ -1337,6 +1337,7 @@ def get_cwl_io_type(io_info, strict=True):
         LOGGER.debug("I/O parsed for multiple base types")
 
     # parse single-definition
+    io_info = io_info.copy()
     io_info["type"] = io_type  # override resolved multi-type base for more parsing
     io_name = io_info["name"]
     io_min_occurs = 0 if is_null else 1