diff --git a/dpdata/amber/md.py b/dpdata/amber/md.py
index cb4f2d25e..32396f0f7 100644
--- a/dpdata/amber/md.py
+++ b/dpdata/amber/md.py
@@ -18,6 +18,78 @@
 force_convert = energy_convert
 
 
+def cell_lengths_angles_to_cell(
+    cell_lengths: np.ndarray, cell_angles: np.ndarray
+) -> np.ndarray:
+    """Convert cell lengths and angles to cell vectors.
+
+    Parameters
+    ----------
+    cell_lengths : np.ndarray
+        Cell lengths with shape (..., 3) where the last dimension
+        corresponds to [a, b, c]
+    cell_angles : np.ndarray
+        Cell angles in degrees with shape (..., 3) where the last dimension
+        corresponds to [alpha, beta, gamma]
+
+    Returns
+    -------
+    np.ndarray
+        Cell vectors with shape (..., 3, 3) where the last two dimensions
+        form the cell matrix
+
+    Notes
+    -----
+    Uses the standard crystallographic convention:
+    - v1 = [a, 0, 0]
+    - v2 = [b*cos(gamma), b*sin(gamma), 0]
+    - v3 = [c*cos(beta), c*(cos(alpha) - cos(beta)*cos(gamma))/sin(gamma), c*z]
+    where z = sqrt(1 - cos²(alpha) - cos²(beta) - cos²(gamma) + 2*cos(alpha)*cos(beta)*cos(gamma))/sin(gamma)
+    """
+    # Convert to radians
+    alpha = np.deg2rad(cell_angles[..., 0])  # angle between b and c
+    beta = np.deg2rad(cell_angles[..., 1])  # angle between a and c
+    gamma = np.deg2rad(cell_angles[..., 2])  # angle between a and b
+
+    a = cell_lengths[..., 0]
+    b = cell_lengths[..., 1]
+    c = cell_lengths[..., 2]
+
+    cos_alpha = np.cos(alpha)
+    cos_beta = np.cos(beta)
+    cos_gamma = np.cos(gamma)
+    sin_gamma = np.sin(gamma)
+
+    # Calculate the z-component of the third vector
+    z_factor = (
+        1
+        - cos_alpha**2
+        - cos_beta**2
+        - cos_gamma**2
+        + 2 * cos_alpha * cos_beta * cos_gamma
+    )
+    z_factor = np.maximum(z_factor, 0)  # Ensure non-negative for sqrt
+    z = np.sqrt(z_factor) / sin_gamma
+
+    # Build cell vectors
+    shape = cell_lengths.shape[:-1] + (3, 3)
+    cell = np.zeros(shape)
+
+    # First vector: [a, 0, 0]
+    cell[..., 0, 0] = a
+
+    # Second vector: [b*cos(gamma), b*sin(gamma), 0]
+    cell[..., 1, 0] = b * cos_gamma
+    cell[..., 1, 1] = b * sin_gamma
+
+    # Third vector: [c*cos(beta), c*(cos(alpha) - cos(beta)*cos(gamma))/sin(gamma), c*z]
+    cell[..., 2, 0] = c * cos_beta
+    cell[..., 2, 1] = c * (cos_alpha - cos_beta * cos_gamma) / sin_gamma
+    cell[..., 2, 2] = c * z
+
+    return cell
+
+
 def read_amber_traj(
     parm7_file,
     nc_file,
@@ -85,15 +157,8 @@ def read_amber_traj(
         coords = np.array(f.variables["coordinates"][:])
         cell_lengths = np.array(f.variables["cell_lengths"][:])
         cell_angles = np.array(f.variables["cell_angles"][:])
-        if np.all(cell_angles > 89.99) and np.all(cell_angles < 90.01):
-            # only support 90
-            # TODO: support other angles
-            shape = cell_lengths.shape
-            cells = np.zeros((shape[0], 3, 3))
-            for ii in range(3):
-                cells[:, ii, ii] = cell_lengths[:, ii]
-        else:
-            raise RuntimeError("Unsupported cells")
+        # Convert cell lengths and angles to cell vectors for all cases
+        cells = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
 
     if labeled:
         with netcdf_file(mdfrc_file, "r") as f:
diff --git a/tests/test_amber_nonorthogonal.py b/tests/test_amber_nonorthogonal.py
new file mode 100644
index 000000000..b1b111111
--- /dev/null
+++ b/tests/test_amber_nonorthogonal.py
@@ -0,0 +1,166 @@
+from __future__ import annotations
+
+import unittest
+
+import numpy as np
+
+from dpdata.amber.md import cell_lengths_angles_to_cell
+
+
+class TestAmberNonOrthogonalCells(unittest.TestCase):
+    def test_orthogonal_cell_conversion(self):
+        """Test that orthogonal cells (90° angles) work correctly."""
+        # Test case: simple cubic cell with a=10, b=15, c=20, all angles=90°
+        cell_lengths = np.array([[10.0, 15.0, 20.0]])
+        cell_angles = np.array([[90.0, 90.0, 90.0]])
+
+        expected_cell = np.array(
+            [[[10.0, 0.0, 0.0], [0.0, 15.0, 0.0], [0.0, 0.0, 20.0]]]
+        )
+
+        result_cell = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
+
+        np.testing.assert_allclose(result_cell, expected_cell, rtol=1e-12, atol=1e-14)
+
+    def test_monoclinic_cell_conversion(self):
+        """Test monoclinic cell (beta != 90°, alpha=gamma=90°)."""
+        # Test case: monoclinic cell with a=10, b=15, c=20, alpha=90°, beta=120°, gamma=90°
+        cell_lengths = np.array([[10.0, 15.0, 20.0]])
+        cell_angles = np.array([[90.0, 120.0, 90.0]])
+
+        # Expected result:
+        # v1 = [10, 0, 0]
+        # v2 = [0, 15, 0] (gamma=90°)
+        # v3 = [20*cos(120°), 0, 20*sin(120°)] = [-10, 0, 17.32...]
+        cos_120 = np.cos(np.deg2rad(120.0))  # -0.5
+        sin_120 = np.sin(np.deg2rad(120.0))  # sqrt(3)/2
+
+        expected_cell = np.array(
+            [
+                [
+                    [10.0, 0.0, 0.0],
+                    [0.0, 15.0, 0.0],
+                    [20.0 * cos_120, 0.0, 20.0 * sin_120],
+                ]
+            ]
+        )
+
+        result_cell = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
+
+        np.testing.assert_allclose(result_cell, expected_cell, rtol=1e-12, atol=1e-14)
+
+    def test_hexagonal_cell_conversion(self):
+        """Test hexagonal cell (gamma=120°, alpha=beta=90°)."""
+        # Test case: hexagonal cell with a=10, b=10, c=15, alpha=90°, beta=90°, gamma=120°
+        cell_lengths = np.array([[10.0, 10.0, 15.0]])
+        cell_angles = np.array([[90.0, 90.0, 120.0]])
+
+        # Expected result:
+        # v1 = [10, 0, 0]
+        # v2 = [10*cos(120°), 10*sin(120°), 0] = [-5, 8.66..., 0]
+        # v3 = [0, 0, 15] (alpha=beta=90°)
+        cos_120 = np.cos(np.deg2rad(120.0))  # -0.5
+        sin_120 = np.sin(np.deg2rad(120.0))  # sqrt(3)/2
+
+        expected_cell = np.array(
+            [
+                [
+                    [10.0, 0.0, 0.0],
+                    [10.0 * cos_120, 10.0 * sin_120, 0.0],
+                    [0.0, 0.0, 15.0],
+                ]
+            ]
+        )
+
+        result_cell = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
+
+        np.testing.assert_allclose(result_cell, expected_cell, rtol=1e-12, atol=1e-14)
+
+    def test_triclinic_cell_conversion(self):
+        """Test triclinic cell (all angles != 90°)."""
+        # Test case: triclinic cell with a=8, b=10, c=12, alpha=70°, beta=80°, gamma=110°
+        cell_lengths = np.array([[8.0, 10.0, 12.0]])
+        cell_angles = np.array([[70.0, 80.0, 110.0]])
+
+        result_cell = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
+
+        # Check that the result has the right shape
+        self.assertEqual(result_cell.shape, (1, 3, 3))
+
+        # Check that the cell vectors have the correct lengths
+        computed_lengths = np.linalg.norm(result_cell[0], axis=1)
+        expected_lengths = np.array([8.0, 10.0, 12.0])
+        np.testing.assert_allclose(computed_lengths, expected_lengths, rtol=1e-12)
+
+        # Check that the angles between vectors are correct
+        v1, v2, v3 = result_cell[0]
+
+        # Angle between v2 and v3 should be alpha (70°)
+        cos_alpha = np.dot(v2, v3) / (np.linalg.norm(v2) * np.linalg.norm(v3))
+        alpha_computed = np.rad2deg(np.arccos(cos_alpha))
+        np.testing.assert_allclose(alpha_computed, 70.0, rtol=1e-8)
+
+        # Angle between v1 and v3 should be beta (80°)
+        cos_beta = np.dot(v1, v3) / (np.linalg.norm(v1) * np.linalg.norm(v3))
+        beta_computed = np.rad2deg(np.arccos(cos_beta))
+        np.testing.assert_allclose(beta_computed, 80.0, rtol=1e-8)
+
+        # Angle between v1 and v2 should be gamma (110°)
+        cos_gamma = np.dot(v1, v2) / (np.linalg.norm(v1) * np.linalg.norm(v2))
+        gamma_computed = np.rad2deg(np.arccos(cos_gamma))
+        np.testing.assert_allclose(gamma_computed, 110.0, rtol=1e-8)
+
+    def test_extreme_angles_case(self):
+        """Test edge case with angles very far from 90°."""
+        cell_lengths = np.array([[5.0, 8.0, 12.0]])
+        cell_angles = np.array([[60.0, 70.0, 130.0]])  # all far from 90°
+
+        # Should work without error
+        result = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
+        self.assertEqual(result.shape, (1, 3, 3))
+
+        # Verify the lengths are preserved
+        computed_lengths = np.linalg.norm(result[0], axis=1)
+        expected_lengths = np.array([5.0, 8.0, 12.0])
+        np.testing.assert_allclose(computed_lengths, expected_lengths, rtol=1e-10)
+
+    def test_multiple_frames(self):
+        """Test that multiple frames are handled correctly."""
+        # Test case: 3 frames with different cell parameters
+        cell_lengths = np.array(
+            [
+                [10.0, 10.0, 10.0],  # cubic
+                [8.0, 12.0, 15.0],  # orthorhombic
+                [10.0, 10.0, 12.0],
+            ]
+        )  # hexagonal-like
+        cell_angles = np.array(
+            [[90.0, 90.0, 90.0], [90.0, 90.0, 90.0], [90.0, 90.0, 120.0]]
+        )
+
+        result_cell = cell_lengths_angles_to_cell(cell_lengths, cell_angles)
+
+        # Check shape
+        self.assertEqual(result_cell.shape, (3, 3, 3))
+
+        # Check first frame (cubic)
+        expected_frame1 = np.array(
+            [[10.0, 0.0, 0.0], [0.0, 10.0, 0.0], [0.0, 0.0, 10.0]]
+        )
+        np.testing.assert_allclose(
+            result_cell[0], expected_frame1, rtol=1e-12, atol=1e-14
+        )
+
+        # Check third frame (hexagonal-like)
+        cos_120 = np.cos(np.deg2rad(120.0))  # -0.5
+        sin_120 = np.sin(np.deg2rad(120.0))  # sqrt(3)/2
+        expected_frame3 = np.array(
+            [[10.0, 0.0, 0.0], [10.0 * cos_120, 10.0 * sin_120, 0.0], [0.0, 0.0, 12.0]]
+        )
+        np.testing.assert_allclose(
+            result_cell[2], expected_frame3, rtol=1e-12, atol=1e-14
+        )
+
+
+if __name__ == "__main__":
+    unittest.main()