Cannot Connect when M33 Fio is installed , and M3D printer is ticked for.

[V-ICE]

Merry Christmas :)

VirtualBox running Ubuntu Server
Octoprint 1.3.6
M33 Fio 1.21
iMe 1.25 (tried original firmware, same results)

As soon as I install M33 Fio it wont connect to printer
Also
When untick "not sing a Micro 3d printer" it wont connect
Log
"Connecting to: /dev/ttyACM0
Changing monitoring state from 'Offline' to 'Opening serial port'
Connected to: Serial<id=0xad4fbdac, open=True>(port='/dev/ttyACM0', baudrate=115200, bytesize=8, parity='N', stopbits=1, timeout=None, xonxoff=False, rtscts=False, dsrdtr=False), starting monitor
Changing monitoring state from 'Opening serial port' to 'Connecting'
Send: N0 M110 N0*125
Changing monitoring state from 'Connecting' to 'Offline'
Connection closed, closing down monitor"

Opens M33 Manager, connects, and switch back to bootloader mode. And the reconnects the usb in Virtualbox. Serilaport apperas in Octoprint, When clicking connect log says
"Connecting to: /dev/ttyACM0
Changing monitoring state from 'Offline' to 'Opening serial port'
Connected to: Serial<id=0xad4d4c0c, open=True>(port='/dev/ttyACM0', baudrate=115200, bytesize=8, parity='N', stopbits=1, timeout=None, xonxoff=False, rtscts=False, dsrdtr=False), starting monitor
Changing monitoring state from 'Opening serial port' to 'Connecting'
Send: N0 M110 N0*125
Connection closed, closing down monitor
Changing monitoring state from 'Connecting' to 'Offline'
"

Please Advise.

When connected log :
"
Connecting to: /dev/ttyACM0
Changing monitoring state from 'Offline' to 'Opening serial port'
Connected to: Serial<id=0xb241c46c, open=True>(port='/dev/ttyACM0', baudrate=115200, bytesize=8, parity='N', stopbits=1, timeout=10.0, xonxoff=False, rtscts=False, dsrdtr=False), starting monitor
Changing monitoring state from 'Opening serial port' to 'Connecting'
Send: N0 M110 N0125
Recv: ok 0
Changing monitoring state from 'Connecting' to 'Operational'
Send: N0 M110 N0125
Recv: ok 0
Send: N1 M11539
Recv: ok 1
Send: N2 M2118
Recv: PROTOCOL:RepRap FIRMWARE_NAME:iMe FIRMWARE_VERSION:00.00.01.25 MACHINE_TYPE:Micro_3D EXTRUDER_COUNT:1 SERIAL_NUMBER:BL1508060105000
Recv: ok 2
Send: M105
Recv: ok
Recv: T:0.0000
Recv: wait
"

[V-ICE]

Probably som Issue With VirtualBox.
Did a test with a windows install and it connect without problems.
But still would be nice to have a VM.

Look into how VirtualBox can be used ?