diff --git a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.cpp b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.cpp
index d1821f6b74b728..8f6b0b548720a5 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.cpp
@@ -145,18 +145,6 @@ RuntimeAgent::~RuntimeAgent() {
   sessionState_.lastRuntimeAgentExportedState = getExportedState();
 }
 
-void RuntimeAgent::enableSamplingProfiler() {
-  targetController_.enableSamplingProfiler();
-}
-
-void RuntimeAgent::disableSamplingProfiler() {
-  targetController_.disableSamplingProfiler();
-}
-
-tracing::RuntimeSamplingProfile RuntimeAgent::collectSamplingProfile() {
-  return targetController_.collectSamplingProfile();
-}
-
 #pragma mark - Tracing
 
 RuntimeTracingAgent::RuntimeTracingAgent(
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.h b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.h
index 186eb0ba4e8d37..593f6d5d9e1286 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.h
+++ b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeAgent.h
@@ -85,21 +85,6 @@ class RuntimeAgent final {
    */
   ExportedState getExportedState();
 
-  /**
-   * Start sampling profiler for the corresponding RuntimeTarget.
-   */
-  void enableSamplingProfiler();
-
-  /**
-   * Stop sampling profiler for the corresponding RuntimeTarget.
-   */
-  void disableSamplingProfiler();
-
-  /**
-   * Return recorded sampling profile for the previous sampling session.
-   */
-  tracing::RuntimeSamplingProfile collectSamplingProfile();
-
  private:
   FrontendChannel frontendChannel_;
   RuntimeTargetController& targetController_;
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.cpp b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.cpp
index a42493ad55cc9e..0f84ecd0e17987 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.cpp
@@ -179,40 +179,71 @@ void RuntimeTarget::notifyDomainStateChanged(
     Domain domain,
     bool enabled,
     const RuntimeAgent& notifyingAgent) {
-  bool runtimeAndLogStatusBefore = false, runtimeAndLogStatusAfter = false;
-  if (domain == Domain::Log || domain == Domain::Runtime) {
-    runtimeAndLogStatusBefore =
-        agentsByEnabledDomain_[Domain::Runtime].contains(&notifyingAgent) &&
-        agentsByEnabledDomain_[Domain::Log].contains(&notifyingAgent);
-  }
-
-  if (enabled) {
-    agentsByEnabledDomain_[domain].insert(&notifyingAgent);
-  } else {
-    agentsByEnabledDomain_[domain].erase(&notifyingAgent);
-  }
-  threadSafeDomainStatus_[domain] = !agentsByEnabledDomain_[domain].empty();
-
-  if (domain == Domain::Log || domain == Domain::Runtime) {
-    runtimeAndLogStatusAfter =
-        agentsByEnabledDomain_[Domain::Runtime].contains(&notifyingAgent) &&
-        agentsByEnabledDomain_[Domain::Log].contains(&notifyingAgent);
+  auto [domainStateChangedLocally, domainStateChangedGlobally] =
+      processDomainChange(domain, enabled, notifyingAgent);
+
+  switch (domain) {
+    case Domain::Log:
+    case Domain::Runtime: {
+      auto otherDomain = domain == Domain::Log ? Domain::Runtime : Domain::Log;
+      // There should be an agent that enables both Log and Runtime domains.
+      if (!agentsByEnabledDomain_[otherDomain].contains(&notifyingAgent)) {
+        break;
+      }
 
-    if (runtimeAndLogStatusBefore != runtimeAndLogStatusAfter) {
-      if (runtimeAndLogStatusAfter) {
+      if (domainStateChangedGlobally && enabled) {
+        assert(agentsWithRuntimeAndLogDomainsEnabled_ == 0);
+        emitDebuggerSessionCreated();
+        ++agentsWithRuntimeAndLogDomainsEnabled_;
+      } else if (domainStateChangedGlobally) {
+        assert(agentsWithRuntimeAndLogDomainsEnabled_ == 1);
+        emitDebuggerSessionDestroyed();
+        --agentsWithRuntimeAndLogDomainsEnabled_;
+      } else if (domainStateChangedLocally && enabled) {
+        // This is a case when given domain was already enabled by other Agent,
+        // so global state didn't change.
         if (++agentsWithRuntimeAndLogDomainsEnabled_ == 1) {
           emitDebuggerSessionCreated();
         }
-      } else {
-        assert(agentsWithRuntimeAndLogDomainsEnabled_ > 0);
+      } else if (domainStateChangedLocally) {
         if (--agentsWithRuntimeAndLogDomainsEnabled_ == 0) {
           emitDebuggerSessionDestroyed();
         }
       }
+
+      break;
+    }
+    case Domain::Network:
+      break;
+    case Domain::kMaxValue: {
+      throw std::logic_error("Unexpected kMaxValue domain value provided");
     }
   }
 }
 
+std::pair<bool, bool> RuntimeTarget::processDomainChange(
+    Domain domain,
+    bool enabled,
+    const RuntimeAgent& notifyingAgent) {
+  bool domainHadAgentsBefore = !agentsByEnabledDomain_[domain].empty();
+  bool domainHasBeenEnabledBefore =
+      agentsByEnabledDomain_[domain].contains(&notifyingAgent);
+
+  if (enabled) {
+    agentsByEnabledDomain_[domain].insert(&notifyingAgent);
+  } else {
+    agentsByEnabledDomain_[domain].erase(&notifyingAgent);
+  }
+  threadSafeDomainStatus_[domain] = !agentsByEnabledDomain_[domain].empty();
+
+  bool domainHasAgentsAfter = !agentsByEnabledDomain_[domain].empty();
+
+  return {
+      domainHasBeenEnabledBefore ^ enabled,
+      domainHadAgentsBefore ^ domainHasAgentsAfter,
+  };
+}
+
 bool RuntimeTarget::isDomainEnabled(Domain domain) const {
   return threadSafeDomainStatus_[domain];
 }
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.h b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.h
index 61e57959486644..480dfcbac5485f 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.h
+++ b/packages/react-native/ReactCommon/jsinspector-modern/RuntimeTarget.h
@@ -21,6 +21,7 @@
 #include <jsinspector-modern/tracing/TraceRecordingState.h>
 
 #include <memory>
+#include <utility>
 
 #ifndef JSINSPECTOR_EXPORT
 #ifdef _MSC_VER
@@ -122,7 +123,7 @@ class RuntimeTargetDelegate {
  */
 class RuntimeTargetController {
  public:
-  enum class Domain { Network, Runtime, Log, kMaxValue };
+  enum class Domain { Log, Network, Runtime, kMaxValue };
 
   explicit RuntimeTargetController(RuntimeTarget& target);
 
@@ -347,6 +348,22 @@ class JSINSPECTOR_EXPORT RuntimeTarget
       bool enabled,
       const RuntimeAgent& notifyingAgent);
 
+  /**
+   * Processes the changes to the state of a given domain.
+   *
+   * Returns a pair of booleans:
+   *   1. Returns true, if an only if the given domain state changed locally,
+   *   for a given session.
+   *   2. Returns true, if and only if the given domain state changed globally:
+   *   when the given Agent is the only Agent that enabled given domain across
+   *   sessions, or when the only Agent that had this domain enabled has
+   *   disconnected.
+   */
+  std::pair<bool, bool> processDomainChange(
+      Domain domain,
+      bool enabled,
+      const RuntimeAgent& notifyingAgent);
+
   /**
    * Checks whether the given domain is enabled in at least one session
    * that is currently connected. This may be called from any thread, with