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Linoleic acid (LA) metabolism (R-HSA-2046105) #336

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ukemi opened this issue Jan 6, 2025 · 0 comments
Open
5 tasks

Linoleic acid (LA) metabolism (R-HSA-2046105) #336

ukemi opened this issue Jan 6, 2025 · 0 comments

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@ukemi
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ukemi commented Jan 6, 2025

  • Make mouse models: http://noctua.geneontology.org/editor/graph/gomodel:675b862c00001348?
  • Clean up of Molecular events in Reactome import
  • Clean up ofpH 7.3 species
  • PMID:21145416 supports that ABCD2 is the main transporter for the polyunsaturated c24 FAs, not ABCD1. Would it be better to make a set?
  • I'm curious as to why the peroxisomal beta-oxidation of the FA was made a black box reaction in this model. Is there not enough evidence to support the parallel pathway to R-HSA-2046106? As I work through the mouse pathways, I will see if I can shed any light on this, but in general the biochemists seem to lump similar substrates together for these types of enzymes.
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