diff --git a/containers/celltypist/Dockerfile b/containers/celltypist/Dockerfile
index ae26fcb..a86f5bf 100644
--- a/containers/celltypist/Dockerfile
+++ b/containers/celltypist/Dockerfile
@@ -3,7 +3,7 @@ FROM python:3.10
 RUN apt-get -y update && apt-get -y install cmake
 
 COPY context/requirements-freeze.txt .
-RUN pip install -r requirements-freeze.txt
+RUN pip install -r requirements-freeze.txt && pip cache purge
 
 ENV CELLTYPIST_FOLDER="/models"
 RUN python -c "import celltypist; celltypist.models.download_models()"
diff --git a/containers/crosswalking/Dockerfile b/containers/crosswalking/Dockerfile
index 19feaee..90ec483 100644
--- a/containers/crosswalking/Dockerfile
+++ b/containers/crosswalking/Dockerfile
@@ -1,7 +1,7 @@
 FROM python:3.10
 
 COPY context/requirements-freeze.txt .
-RUN pip install -r requirements-freeze.txt
+RUN pip install -r requirements-freeze.txt && pip cache purge
 
 COPY context/ .
 
diff --git a/containers/extract-summary/Dockerfile b/containers/extract-summary/Dockerfile
index def1204..e46416f 100644
--- a/containers/extract-summary/Dockerfile
+++ b/containers/extract-summary/Dockerfile
@@ -1,7 +1,7 @@
 FROM python:3.10
 
 COPY context/requirements-freeze.txt .
-RUN pip install -r requirements-freeze.txt
+RUN pip install -r requirements-freeze.txt && pip cache purge
 
 COPY context/ .
 
diff --git a/containers/gene-expression/Dockerfile b/containers/gene-expression/Dockerfile
index 19feaee..90ec483 100644
--- a/containers/gene-expression/Dockerfile
+++ b/containers/gene-expression/Dockerfile
@@ -1,7 +1,7 @@
 FROM python:3.10
 
 COPY context/requirements-freeze.txt .
-RUN pip install -r requirements-freeze.txt
+RUN pip install -r requirements-freeze.txt && pip cache purge
 
 COPY context/ .
 
diff --git a/containers/popv/Dockerfile b/containers/popv/Dockerfile
index 5e6ecee..7bda49d 100644
--- a/containers/popv/Dockerfile
+++ b/containers/popv/Dockerfile
@@ -1,12 +1,12 @@
 FROM tensorflow/tensorflow:2.11.1
 
-RUN apt-get -y update && apt-get -y install python3-dev g++ git wget
+RUN apt-get -y update && apt-get -y install python3-dev g++ git wget && apt-get clean
 
 COPY context/download-ontology.sh .
 RUN ./download-ontology.sh
 
 COPY context/requirements-freeze.txt .
-RUN pip install -r requirements-freeze.txt
+RUN pip install -r requirements-freeze.txt && pip cache purge
 
 COPY context/ .