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NEWS.md

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simIDM 0.1.0.9006

New Features

  • estimateParams estimates parameters of exponential and Weibull transition hazards using maximum likelihood for a given data set after using prepareData.
  • corTrans calculates the correlation between PFS and OS for a given set of transition hazards, and corPFSOS estimates this correlation for a given data set, optionally with a bootstrap based confidence interval.

Bug Fixes

  • ExpSurvOS now returns 0 instead of NaN for large values of t.
  • WeibSurvOS now does not return an error for large values of t.
  • PWCSurvOS now does not return an error for large values of t. It also no longer returns values larger than 1. It is significantly faster, based on a closed form calculation instead of numerical integration.
  • getSimulatedData now also works when there are no transitions from progression to death, similarly for getOneClinicalTrial (which now warns if there are no such transitions at all).
  • corPFSOS now undoes the future plan upon function exit.

Miscellaneous

  • PwcOSInt, integrateVector, WeibOSInteg are no longer exported, and only used internally.
  • Renamed piecewise constant hazards function to getPWCHazard (previously getPCWHazard).

simIDM 0.0.5

  • First CRAN version of the package.
  • The package simulates illness-death models with constant, Weibull or piecewise constant transition hazards.

New Features

  • Exponentially, Weibull and piecewise exponentially distributed survival times.
  • Random censoring and event-driven censoring after a pre-specified number of PFS or OS events.
  • Arbitrary number of treatment arms and flexible randomization ratio.
  • Staggered study entry.
  • Derivation of PFS and OS survival functions from transition hazards.