diff --git a/boring-sys/Cargo.toml b/boring-sys/Cargo.toml
index ce49709d2..5f739b334 100644
--- a/boring-sys/Cargo.toml
+++ b/boring-sys/Cargo.toml
@@ -64,6 +64,10 @@ rpk = []
 # `BORING_BSSL{,_FIPS}_SOURCE_PATH`.
 underscore-wildcards = []
 
+# Add a prefix to all symbols in libcrypto and libssl to prevent conflicts
+# with other OpenSSL/BoringSSL versions in the same process.
+prefix-symbols = []
+
 [build-dependencies]
 bindgen = { workspace = true }
 cmake = { workspace = true }
diff --git a/boring-sys/build/config.rs b/boring-sys/build/config.rs
index 25aaabf40..a8aaed629 100644
--- a/boring-sys/build/config.rs
+++ b/boring-sys/build/config.rs
@@ -18,6 +18,7 @@ pub(crate) struct Features {
     pub(crate) fips: bool,
     pub(crate) rpk: bool,
     pub(crate) underscore_wildcards: bool,
+    pub(crate) prefix_symbols: bool,
 }
 
 pub(crate) struct Env {
@@ -105,11 +106,13 @@ impl Features {
         let fips = env::var_os("CARGO_FEATURE_FIPS").is_some();
         let rpk = env::var_os("CARGO_FEATURE_RPK").is_some();
         let underscore_wildcards = env::var_os("CARGO_FEATURE_UNDERSCORE_WILDCARDS").is_some();
+        let prefix_symbols = env::var_os("CARGO_FEATURE_PREFIX_SYMBOLS").is_some();
 
         Self {
             fips,
             rpk,
             underscore_wildcards,
+            prefix_symbols,
         }
     }
 
diff --git a/boring-sys/build/main.rs b/boring-sys/build/main.rs
index 41789cee3..2cd64aca1 100644
--- a/boring-sys/build/main.rs
+++ b/boring-sys/build/main.rs
@@ -9,8 +9,10 @@ use std::process::{Command, Output};
 use std::sync::OnceLock;
 
 use crate::config::Config;
+use crate::prefix::{apply_symbol_prefixes, SymbolPrefixCallbacks};
 
 mod config;
+mod prefix;
 
 fn should_use_cmake_cross_compilation(config: &Config) -> bool {
     if config.host == config.target {
@@ -543,6 +545,13 @@ fn built_boring_source_path(config: &Config) -> &PathBuf {
                 .define("FIPS", "1");
         }
 
+        // We must enable Position Independent Code to ensure that the
+        // resulting prefixed symbols remain compatible with the relocatable
+        // nature of the final Rust test binaries to prevent linker errors
+        if config.features.prefix_symbols {
+            cfg.define("CMAKE_POSITION_INDEPENDENT_CODE", "ON");
+        }
+
         cfg.build_target("ssl").build();
         cfg.build_target("crypto").build()
     })
@@ -570,6 +579,9 @@ fn main() {
     if !config.env.docs_rs {
         emit_link_directives(&config);
     }
+    if config.features.prefix_symbols {
+        apply_symbol_prefixes(&config);
+    }
     generate_bindings(&config);
 }
 
@@ -658,6 +670,10 @@ fn generate_bindings(config: &Config) {
         .clang_arg("-I")
         .clang_arg(include_path.display().to_string());
 
+    if config.features.prefix_symbols {
+        builder = builder.parse_callbacks(Box::new(SymbolPrefixCallbacks));
+    }
+
     if let Some(sysroot) = &config.env.sysroot {
         builder = builder
             .clang_arg("--sysroot")
diff --git a/boring-sys/build/prefix.rs b/boring-sys/build/prefix.rs
new file mode 100644
index 000000000..4fcfb3df2
--- /dev/null
+++ b/boring-sys/build/prefix.rs
@@ -0,0 +1,98 @@
+use crate::{config::Config, run_command};
+use std::{fs, io::Write, path::PathBuf, process::Command};
+
+/// Prefix applied to all BoringSSL symbols so they don't collide with OpenSSL.
+/// Uses the crate version to generate a dynamic prefix.
+const SYMBOL_PREFIX: &str = concat!(
+    "BSSL_",
+    env!("CARGO_PKG_VERSION_MAJOR"),
+    "_",
+    env!("CARGO_PKG_VERSION_MINOR"),
+    "_",
+    env!("CARGO_PKG_VERSION_PATCH"),
+);
+
+/// Bindgen callback that rewrites link names to use the prefixed symbol.
+///
+/// C symbol `SSL_new` → Rust binding `#[link_name = "BSSL_SSL_new"]`.
+#[derive(Debug)]
+pub struct SymbolPrefixCallbacks;
+
+impl bindgen::callbacks::ParseCallbacks for SymbolPrefixCallbacks {
+    fn generated_link_name_override(
+        &self,
+        item_info: bindgen::callbacks::ItemInfo<'_>,
+    ) -> Option<String> {
+        Some(format!("{SYMBOL_PREFIX}_{}", item_info.name))
+    }
+}
+
+/// Rewrite all global symbols in libssl.a/libcrypto.a to use the S2N_BSSL_ prefix.
+///
+/// This runs `nm` to list symbols and `objcopy --redefine-syms` to edit the archives
+/// in-place, so they can safely coexist with other {libssl,libcrypto} in the process.
+pub fn apply_symbol_prefixes(config: &Config) {
+    // CMake output directories where libssl.a/libcrypto.a are expected.
+    let static_lib_dirs = [
+        config.out_dir.join("build"),
+        config.out_dir.join("build").join("ssl"),
+        config.out_dir.join("build").join("crypto"),
+    ];
+
+    let static_libs: Vec<PathBuf> = static_lib_dirs
+        .iter()
+        .flat_map(|dir| {
+            ["libssl.a", "libcrypto.a"]
+                .into_iter()
+                .map(move |file| dir.join(file))
+        })
+        .filter(|path| path.exists())
+        .collect();
+
+    if static_libs.is_empty() {
+        eprintln!("warning: no libssl.a/libcrypto.a archives found to prefix");
+        return;
+    }
+
+    // 1. Use `nm` to list global symbols in the archives.
+    let nm_output = run_command(Command::new("nm").args(&static_libs))
+        .expect("failed to run `nm` on BoringSSL archives");
+
+    let mut mappings: Vec<String> = String::from_utf8_lossy(&nm_output.stdout)
+        .lines()
+        // Keep only global symbol types we care about.
+        .filter(|line| {
+            [" T ", " D ", " B ", " C ", " R ", " W "]
+                .iter()
+                .any(|marker| line.contains(marker))
+        })
+        // Symbol name is usually the 3rd column.
+        .filter_map(|line| line.split_whitespace().nth(2).map(str::to_owned))
+        // Skip leading-underscore internals.
+        .filter(|sym| !sym.starts_with('_'))
+        // Compose `old new` mapping line: `sym S2N_BSSL_sym`.
+        .map(|sym| format!("{sym} {SYMBOL_PREFIX}_{sym}"))
+        .collect();
+
+    mappings.sort();
+    mappings.dedup();
+
+    let mapping_file = config.out_dir.join("redefine_syms.txt");
+    let mut f = fs::File::create(&mapping_file)
+        .expect("failed to create redefine_syms.txt for symbol prefixing");
+
+    for mapping in &mappings {
+        writeln!(f, "{mapping}").expect("failed to write symbol mapping");
+    }
+    f.flush().expect("failed to flush symbol mapping file");
+
+    // 2. Use `objcopy` to apply the mapping to each archive in-place.
+    for static_lib in &static_libs {
+        run_command(
+            Command::new("objcopy")
+                .arg(format!("--redefine-syms={}", mapping_file.display()))
+                .arg(static_lib),
+        )
+        .expect("failed to run `objcopy` to redefine symbols");
+    }
+}
diff --git a/boring/Cargo.toml b/boring/Cargo.toml
index d76c92945..76081955a 100644
--- a/boring/Cargo.toml
+++ b/boring/Cargo.toml
@@ -38,6 +38,8 @@ rpk = ["boring-sys/rpk"]
 # feature set can be provided by setting `BORING_BSSL{,_FIPS}_SOURCE_PATH` and
 # `BORING_BSSL{,_FIPS}_ASSUME_PATCHED`.
 underscore-wildcards = ["boring-sys/underscore-wildcards"]
+# Enable symbol prefixing in the underlying BoringSSL build (for s2n tests).
+prefix-symbols = ["boring-sys/prefix-symbols"]
 
 [dependencies]
 bitflags = { workspace = true }