diff --git a/CMakeLists.txt b/CMakeLists.txt
index 03d22a43..617b12ad 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -91,7 +91,7 @@ if(NOT isMultiConfig AND NOT CMAKE_BUILD_TYPE)
 endif()
 
 if(CMAKE_BUILD_TYPE STREQUAL "Debug")
-    set(ENABLE_ASSERT "ENABLE_ASSERT")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "ENABLE_ASSERT")
 endif()
 
 # primecount binary source files #####################################
@@ -173,7 +173,7 @@ endif()
 
 if(WITH_FLOAT128)
     set(LIB_QUADMATH "quadmath")
-    set(HAVE_FLOAT128 "HAVE_FLOAT128")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "HAVE_FLOAT128")
 endif()
 
 # Use 32-bit integer division ########################################
@@ -183,7 +183,7 @@ endif()
 # division. On most CPUs before 2020 this significantly
 # improves performance.
 if(WITH_DIV32)
-    set(ENABLE_DIV32 "ENABLE_DIV32")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "ENABLE_DIV32")
 endif()
 
 # Use -Wno-uninitialized with GCC compiler ###########################
@@ -252,7 +252,7 @@ if(BUILD_SHARED_LIBS)
     set_target_properties(libprimecount PROPERTIES SOVERSION ${PRIMECOUNT_VERSION_MAJOR})
     set_target_properties(libprimecount PROPERTIES VERSION ${PRIMECOUNT_VERSION})
     target_compile_options(libprimecount PRIVATE "${WNO_UNINITIALIZED}")
-    target_compile_definitions(libprimecount PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(libprimecount PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(libprimecount PRIVATE primesieve::primesieve "${LIB_OPENMP}" "${LIB_QUADMATH}" "${LIB_ATOMIC}")
 
     target_compile_features(libprimecount
@@ -277,7 +277,7 @@ if(BUILD_STATIC_LIBS)
     add_library(libprimecount-static STATIC ${LIB_SRC})
     set_target_properties(libprimecount-static PROPERTIES OUTPUT_NAME primecount)
     target_compile_options(libprimecount-static PRIVATE "${WNO_UNINITIALIZED}")
-    target_compile_definitions(libprimecount-static PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(libprimecount-static PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(libprimecount-static PRIVATE primesieve::primesieve "${LIB_OPENMP}" "${LIB_QUADMATH}" "${LIB_ATOMIC}")
 
     if(WITH_MSVC_CRT_STATIC)
@@ -313,7 +313,7 @@ endif()
 if(BUILD_PRIMECOUNT)
     add_executable(primecount ${BIN_SRC})
     target_link_libraries(primecount PRIVATE primecount::primecount primesieve::primesieve)
-    target_compile_definitions(primecount PRIVATE "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(primecount PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_compile_features(primecount PRIVATE cxx_auto_type)
     install(TARGETS primecount DESTINATION ${CMAKE_INSTALL_BINDIR})
 
diff --git a/cmake/OpenMP.cmake b/cmake/OpenMP.cmake
index fa06b32b..e90b907a 100644
--- a/cmake/OpenMP.cmake
+++ b/cmake/OpenMP.cmake
@@ -118,7 +118,7 @@ if(OpenMP_FOUND OR OpenMP_CXX_FOUND)
                     }" OpenMP_int128_patch)
 
                 if(OpenMP_int128_patch)
-                    set(ENABLE_INT128_OPENMP_PATCH "ENABLE_INT128_OPENMP_PATCH")
+                    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "ENABLE_INT128_OPENMP_PATCH")
                 endif()
             endif()
         endif()
diff --git a/cmake/int128_t.cmake b/cmake/int128_t.cmake
index 528589c4..bc1db5ff 100644
--- a/cmake/int128_t.cmake
+++ b/cmake/int128_t.cmake
@@ -45,7 +45,7 @@ check_cxx_source_compiles("
     }" int128)
 
 if(NOT int128)
-    set(DISABLE_INT128 "DISABLE_INT128")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "DISABLE_INT128")
 endif()
 
 cmake_pop_check_state()
diff --git a/cmake/multiarch_arm_sve.cmake b/cmake/multiarch_arm_sve.cmake
index 6d52c16c..00a871e6 100644
--- a/cmake/multiarch_arm_sve.cmake
+++ b/cmake/multiarch_arm_sve.cmake
@@ -72,7 +72,7 @@ check_cxx_source_compiles("
 " multiarch_arm_sve)
 
 if(multiarch_arm_sve)
-    set(ENABLE_MULTIARCH "ENABLE_MULTIARCH_ARM_SVE")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "ENABLE_MULTIARCH_ARM_SVE")
 endif()
 
 cmake_pop_check_state()
diff --git a/cmake/multiarch_avx512_vpopcnt.cmake b/cmake/multiarch_avx512_vpopcnt.cmake
index 49c02d6f..9666d1db 100644
--- a/cmake/multiarch_avx512_vpopcnt.cmake
+++ b/cmake/multiarch_avx512_vpopcnt.cmake
@@ -75,7 +75,7 @@ check_cxx_source_compiles("
 " multiarch_avx512_vpopcnt)
 
 if(multiarch_avx512_vpopcnt)
-    set(ENABLE_MULTIARCH "${ENABLE_MULTIARCH} ENABLE_MULTIARCH_AVX512_BMI2")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "ENABLE_MULTIARCH_AVX512_BMI2")
 endif()
 
 cmake_pop_check_state()
diff --git a/cmake/multiarch_x86_popcnt.cmake b/cmake/multiarch_x86_popcnt.cmake
index d9bdadfd..45b6d116 100644
--- a/cmake/multiarch_x86_popcnt.cmake
+++ b/cmake/multiarch_x86_popcnt.cmake
@@ -47,7 +47,7 @@ check_cxx_source_compiles("
 " multiarch_x86_popcnt)
 
 if(multiarch_x86_popcnt)
-    set(ENABLE_MULTIARCH "${ENABLE_MULTIARCH} ENABLE_MULTIARCH_x86_POPCNT")
+    list(APPEND PRIMECOUNT_COMPILE_DEFINITIONS "ENABLE_MULTIARCH_x86_POPCNT")
 endif()
 
 cmake_pop_check_state()
diff --git a/test/CMakeLists.txt b/test/CMakeLists.txt
index 1ae036b0..83c21d1d 100644
--- a/test/CMakeLists.txt
+++ b/test/CMakeLists.txt
@@ -3,7 +3,7 @@ file(GLOB files "*.cpp")
 foreach(file ${files})
     get_filename_component(binary_name ${file} NAME_WE)
     add_executable(${binary_name} ${file})
-    target_compile_definitions(${binary_name} PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(${binary_name} PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(${binary_name} primecount::primecount primesieve::primesieve "${LIB_OPENMP}" "${LIB_ATOMIC}")
     add_test(NAME ${binary_name} COMMAND ${binary_name})
 endforeach()
diff --git a/test/api/CMakeLists.txt b/test/api/CMakeLists.txt
index dfc53803..08968987 100644
--- a/test/api/CMakeLists.txt
+++ b/test/api/CMakeLists.txt
@@ -4,7 +4,7 @@ file(GLOB files "*.cpp" "*.c")
 foreach(file ${files})
     get_filename_component(binary_name ${file} NAME_WE)
     add_executable(${binary_name} ${file})
-    target_compile_definitions(${binary_name} PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(${binary_name} PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(${binary_name} primecount::primecount primesieve::primesieve "${LIB_OPENMP}" "${LIB_ATOMIC}")
     add_test(NAME ${binary_name} COMMAND ${binary_name})
 endforeach()
diff --git a/test/deleglise-rivat/CMakeLists.txt b/test/deleglise-rivat/CMakeLists.txt
index 91d915a8..74986746 100644
--- a/test/deleglise-rivat/CMakeLists.txt
+++ b/test/deleglise-rivat/CMakeLists.txt
@@ -3,7 +3,7 @@ file(GLOB files "*.cpp")
 foreach(file ${files})
     get_filename_component(binary_name ${file} NAME_WE)
     add_executable(${binary_name} ${file})
-    target_compile_definitions(${binary_name} PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(${binary_name} PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(${binary_name} primecount::primecount primesieve::primesieve "${LIB_OPENMP}" "${LIB_ATOMIC}")
     add_test(NAME ${binary_name} COMMAND ${binary_name})
 endforeach()
diff --git a/test/gourdon/CMakeLists.txt b/test/gourdon/CMakeLists.txt
index 91d915a8..74986746 100644
--- a/test/gourdon/CMakeLists.txt
+++ b/test/gourdon/CMakeLists.txt
@@ -3,7 +3,7 @@ file(GLOB files "*.cpp")
 foreach(file ${files})
     get_filename_component(binary_name ${file} NAME_WE)
     add_executable(${binary_name} ${file})
-    target_compile_definitions(${binary_name} PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(${binary_name} PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(${binary_name} primecount::primecount primesieve::primesieve "${LIB_OPENMP}" "${LIB_ATOMIC}")
     add_test(NAME ${binary_name} COMMAND ${binary_name})
 endforeach()
diff --git a/test/lmo/CMakeLists.txt b/test/lmo/CMakeLists.txt
index 91d915a8..74986746 100644
--- a/test/lmo/CMakeLists.txt
+++ b/test/lmo/CMakeLists.txt
@@ -3,7 +3,7 @@ file(GLOB files "*.cpp")
 foreach(file ${files})
     get_filename_component(binary_name ${file} NAME_WE)
     add_executable(${binary_name} ${file})
-    target_compile_definitions(${binary_name} PRIVATE "${HAVE_FLOAT128}" "${DISABLE_INT128}" "${ENABLE_DIV32}" "${ENABLE_ASSERT}" "${ENABLE_MULTIARCH}" "${ENABLE_INT128_OPENMP_PATCH}")
+    target_compile_definitions(${binary_name} PRIVATE ${PRIMECOUNT_COMPILE_DEFINITIONS})
     target_link_libraries(${binary_name} primecount::primecount primesieve::primesieve "${LIB_OPENMP}" "${LIB_ATOMIC}")
     add_test(NAME ${binary_name} COMMAND ${binary_name})
 endforeach()