diff --git a/nodeup/pkg/model/networking/amazon-vpc-routed-eni.go b/nodeup/pkg/model/networking/amazon-vpc-routed-eni.go
new file mode 100644
index 0000000000000..3ced7a9eef729
--- /dev/null
+++ b/nodeup/pkg/model/networking/amazon-vpc-routed-eni.go
@@ -0,0 +1,59 @@
+/*
+Copyright 2024 The Kubernetes Authors.
+
+Licensed under the Apache License, Version 2.0 (the "License");
+you may not use this file except in compliance with the License.
+You may obtain a copy of the License at
+
+    http://www.apache.org/licenses/LICENSE-2.0
+
+Unless required by applicable law or agreed to in writing, software
+distributed under the License is distributed on an "AS IS" BASIS,
+WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+See the License for the specific language governing permissions and
+limitations under the License.
+*/
+
+package networking
+
+import (
+	"k8s.io/kops/nodeup/pkg/model"
+	"k8s.io/kops/upup/pkg/fi"
+	"k8s.io/kops/upup/pkg/fi/nodeup/nodetasks"
+)
+
+// AmazonVPCRoutedENIBuilder writes the Amazon VPC CNI configuration
+type AmazonVPCRoutedENIBuilder struct {
+	*model.NodeupModelContext
+}
+
+var _ fi.NodeupModelBuilder = &AmazonVPCRoutedENIBuilder{}
+
+// Build is responsible for configuring the network cni
+func (b *AmazonVPCRoutedENIBuilder) Build(c *fi.NodeupModelBuilderContext) error {
+	if b.NodeupConfig.Networking.AmazonVPC == nil {
+		return nil
+	}
+
+	// Running Amazon VPC CNI on Ubuntu 22.04 and later requires setting MACAddressPolicy to `none` (ref: https://github.com/aws/amazon-vpc-cni-k8s/issues/2103 & https://github.com/kubernetes/kops/issues/16255)
+	if b.Distribution.IsUbuntu() && b.Distribution.Version() >= 22.04 {
+		contents := `
+[Match]
+OriginalName=*
+[Link]
+NamePolicy=keep kernel database onboard slot path
+AlternativeNamesPolicy=database onboard slot path
+MACAddressPolicy=none
+`
+
+		// Copy all the relevant entries and replace the one that contains MACAddressPolicy= with MACAddressPolicy=none
+		c.AddTask(&nodetasks.File{
+			Path:            "/etc/systemd/network/99-default.link",
+			Contents:        fi.NewStringResource(contents),
+			Type:            nodetasks.FileType_File,
+			OnChangeExecute: [][]string{{"systemctl", "restart", "systemd-networkd"}},
+		})
+
+	}
+	return nil
+}
diff --git a/upup/pkg/fi/nodeup/command.go b/upup/pkg/fi/nodeup/command.go
index 41eb58733b375..5121be3aa74f2 100644
--- a/upup/pkg/fi/nodeup/command.go
+++ b/upup/pkg/fi/nodeup/command.go
@@ -315,6 +315,7 @@ func (c *NodeUpCommand) Run(out io.Writer) error {
 	loader.Builders = append(loader.Builders, &networking.CommonBuilder{NodeupModelContext: modelContext})
 	loader.Builders = append(loader.Builders, &networking.CalicoBuilder{NodeupModelContext: modelContext})
 	loader.Builders = append(loader.Builders, &networking.CiliumBuilder{NodeupModelContext: modelContext})
+	loader.Builders = append(loader.Builders, &networking.AmazonVPCRoutedENIBuilder{NodeupModelContext: modelContext})
 	loader.Builders = append(loader.Builders, &networking.KuberouterBuilder{NodeupModelContext: modelContext})
 
 	loader.Builders = append(loader.Builders, &model.BootstrapClientBuilder{NodeupModelContext: modelContext})