diff --git a/libc/CMakeLists.txt b/libc/CMakeLists.txt
index 47708c2267818..a4fbba92c2727 100644
--- a/libc/CMakeLists.txt
+++ b/libc/CMakeLists.txt
@@ -128,7 +128,13 @@ else()
   endif()
 endif()
 
-option(LLVM_LIBC_FULL_BUILD "Build and test LLVM libc as if it is the full libc" OFF)
+# Some targets can only support the full build.
+set(default_to_full_build OFF)
+if(LIBC_TARGET_OS_IS_GPU)
+  set(default_to_full_build ON)
+endif()
+
+option(LLVM_LIBC_FULL_BUILD "Build and test LLVM libc as if it is the full libc" ${default_to_full_build})
 option(LLVM_LIBC_IMPLEMENTATION_DEFINED_TEST_BEHAVIOR "Build LLVM libc tests assuming our implementation-defined behavior" ON)
 option(LLVM_LIBC_ENABLE_LINTING "Enables linting of libc source files" OFF)
 
diff --git a/llvm/runtimes/CMakeLists.txt b/llvm/runtimes/CMakeLists.txt
index 2370b41fb7f0b..77a82ed196cd9 100644
--- a/llvm/runtimes/CMakeLists.txt
+++ b/llvm/runtimes/CMakeLists.txt
@@ -535,7 +535,6 @@ if(build_runtimes)
              "-DRUNTIMES_amdgcn-amd-amdhsa_LIBC_GPU_LOADER_EXECUTABLE=$<TARGET_FILE:amdhsa-loader>")
         list(APPEND extra_deps amdhsa-loader)
       endif()
-      list(APPEND extra_cmake_args "-DRUNTIMES_amdgcn-amd-amdhsa_LLVM_LIBC_FULL_BUILD=ON")
     endif()
     if("libc" IN_LIST RUNTIMES_nvptx64-nvidia-cuda_LLVM_ENABLE_RUNTIMES)
       if(TARGET nvptx-loader)
@@ -543,7 +542,6 @@ if(build_runtimes)
              "-DRUNTIMES_nvptx64-nvidia-cuda_LIBC_GPU_LOADER_EXECUTABLE=$<TARGET_FILE:nvptx-loader>")
         list(APPEND extra_deps nvptx-loader)
       endif()
-      list(APPEND extra_cmake_args "-DRUNTIMES_nvptx64-nvidia-cuda_LLVM_LIBC_FULL_BUILD=ON")
     endif()
     if(TARGET clang-offload-packager)
       list(APPEND extra_deps clang-offload-packager)