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features.js
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features.js
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//section: sharing and copying
function outputimage(arg, filename) { //if arg ==1 force share
//off tooltipfirst
//myChart.options.plugins.tooltip.enabled = false;
if ((navigator.canShare) && (arg==1)) {
if (filename.length > 0) {
} else {
filename = "picture";
}
if (newCanvasReady == 2) {
outputimage2(filename);
}
} else {
var canvas = document.getElementById("myChart");
var outputimage = newCanvas.toDataURL();
if (filename.length > 0) {
} else {
filename = "download";
}
console.log(`Your system doesn't support sharing files.`);
const link = document.createElement('a');
if (newCanvasReady == 2) {
link.download = filename + '.png';
link.href = newCanvas.toDataURL();
link.click();
link.delete;
}
}
//myChart.options.plugins.tooltip.enabled = true;
myChart.update;
}
function previewshareoutput() {
var canvas = document.getElementById("myChart");
canvasUpdate(canvas);
clearInterval(canvasUpdateInterval);
canvasUpdateInterval = null;
canvasUpdateInterval = setInterval(canvasUpdate, 2999, canvas);
document.getElementById("sharedatatext").value = 'https://simtiva.app/view.html?P=' + LZString.compressToEncodedURIComponent(outputstring());
}
function updatedatatext() {
clearTimeout(texttimeout);
texttimeout = setTimeout(function() {
savefile_patient();
document.getElementById("sharedatatext").value = 'https://simtiva.app/view.html?P=' + LZString.compressToEncodedURIComponent(outputstring());
},500);
}
async function outputimage2(filename) { //arg is to write the image to share box
var canvas = document.getElementById("myChart");
var outputimage = newCanvas.toDataURL();
const blob = await (await fetch(outputimage)).blob();
var file = new File([blob], "picture.png", {type: "image/png", lastModified: new Date().getTime()});
var filesArray = [file];
navigator.share({
files: filesArray,
title: filename,
text: 'From SimTIVA: https://simtiva.app',
});
}
function copyfunction() {
//if (window.clipboardData && window.clipboardData.setData) {
// Internet Explorer-specific code path to prevent textarea being shown while dialog is visible.
// return window.clipboardData.setData("Text", document.getElementById("sharedatatext").value);
//}
//else if (document.queryCommandSupported && document.queryCommandSupported("copy")) {
var textarea = document.createElement("textarea");
textarea.textContent = document.getElementById("sharedatatext").value;
//alert(textarea.textContent);
textarea.style.position = "fixed"; // Prevent scrolling to bottom of page in Microsoft Edge.
document.body.appendChild(textarea);
textarea.select();
try {
document.getElementById("sharedatatext").focus();
document.getElementById("sharedatatext").select();
document.getElementById("copycheckmark").classList.toggle("translate");
setTimeout(function() {document.getElementById("copycheckmark").classList.toggle("translate")}, 3000);
return document.execCommand("copy"); // Security exception may be thrown by some browsers.
}
catch (ex) {
console.warn("Copy to clipboard failed.", ex);
return prompt("Copy to clipboard: Ctrl+C, Enter", text);
}
finally {
document.body.removeChild(textarea);
}
//}
}
function sharefunction() {
if (document.getElementById('sharebutton').style.display == "block") {
if (navigator.canShare) {
} else {
document.getElementById("btn_shareimg").style.display="none";
document.getElementById("btn_shareweblink").style.display="none";
}
//to prevent pop-under another modal bug
if (modal == undefined) {
previewshareoutput();
setmodal("modalShare");
}
}
}
async function shareViewURL() {
const url = 'https://simtiva.app/view.html?P=' + LZString.compressToEncodedURIComponent(outputstring());
name = document.getElementById("inputFileName").value;
if ((name != undefined) && (name.length>0)) {
} else {
name = "SimTIVA";
}
const shareData = {
title: name,
text: "Results available on SimTIVA viewer app",
url: url
}
try {
await navigator.share(shareData);
} catch(err) {
console.log(err);
}
}
function canvasUpdate(oldCanvas, filename) {
newCanvas = cloneCanvas(oldCanvas,filename);
newCanvasReady = 0;
context = newCanvas.getContext('2d');
if (complex_mode == 1) {
//draw something old
myChart.options.animation = false;
myChart.legend.options.display = true;
myChart.data.datasets[2].hidden=false;
myChart.data.datasets[3].hidden=false;
if (PD_mode>1) {
myChart.data.datasets[6].hidden=false;
myChart.data.datasets[7].hidden=false;
myChart.data.datasets[8].hidden=true;
myChart.data.datasets[9].hidden=true;
} else if (PD_mode == 1) {
myChart.data.datasets[10].hidden=false;
myChart.data.datasets[11].hidden=false;
}
myChart.data.datasets[4].hidden=true;
myChart.data.datasets[5].hidden=true;
if (active_drug_set_index == 0) { corY = result_e } else { corY = alt_result_e };
if (corY>0.1 && corY<=1.6) {
myChart.options.scales.y.max = 5;
myChart.options.scales.y.ticks.stepSize = 0.5;
} else if (corY>1.6 && corY<=4) {
myChart.options.scales.y.max = 5;
myChart.options.scales.y.ticks.stepSize = 0.5;
} else if (corY>4 && corY<=7) {
myChart.options.scales.y.max = 8;
myChart.options.scales.y.ticks.stepSize = 1;
} else if (corY>7 && corY<=11) {
myChart.options.scales.y.max = 12;
myChart.options.scales.y.ticks.stepSize = 1;
} else if (corY>11) {
myChart.options.scales.y.max = 15;
myChart.options.scales.y.ticks.stepSize = 1;
}
myChart.update();
//draw something new here
setTimeout(function() {
context.drawImage(document.getElementById('myChart'), 0, textheight);
newCanvasReady = 1;
myChart.options.animation = false;
myChart.data.datasets[2].hidden=true;
myChart.data.datasets[3].hidden=true;
if (PD_mode>1) {
myChart.data.datasets[6].hidden=true;
myChart.data.datasets[7].hidden=true;
myChart.data.datasets[8].hidden=false;
myChart.data.datasets[9].hidden=false;
} else if (PD_mode == 1) {
myChart.data.datasets[10].hidden=true;
myChart.data.datasets[11].hidden=true;
}
myChart.data.datasets[4].hidden=false;
myChart.data.datasets[5].hidden=false;
if (active_drug_set_index == 0) { corY = alt_result_e } else { corY = result_e };
if (drug_sets[1].drug_name == "Alfentanil") {
if (corY<=70) {
myChart.options.scales.y.max = 100;
myChart.options.scales.y.ticks.stepSize = 20;
} else if (corY>70 && corY<=120) {
myChart.options.scales.y.max = 160;
myChart.options.scales.y.ticks.stepSize = 20;
} else if (corY>120 && corY<=180) {
myChart.options.scales.y.max = 200;
myChart.options.scales.y.ticks.stepSize = 20;
} else if (corY>180 && corY<=280) {
myChart.options.scales.y.max = 300;
myChart.options.scales.y.ticks.stepSize = 50;
} else if (corY>280 && corY<400) {
myChart.options.scales.y.max = 500;
myChart.options.scales.y.ticks.stepSize = 50;
} else {
myChart.options.scales.y.max = 600;
myChart.options.scales.y.ticks.stepSize = 50;
}
} else {
if (corY>0.1 && corY<=1.6) {
myChart.options.scales.y.max = 5;
myChart.options.scales.y.ticks.stepSize = 0.5;
} else if (corY>1.6 && corY<=4) {
myChart.options.scales.y.max = 5;
myChart.options.scales.y.ticks.stepSize = 0.5;
} else if (corY>4 && corY<=7) {
myChart.options.scales.y.max = 8;
myChart.options.scales.y.ticks.stepSize = 1;
} else if (corY>7 && corY<=11) {
myChart.options.scales.y.max = 12;
myChart.options.scales.y.ticks.stepSize = 1;
} else if (corY>11) {
myChart.options.scales.y.max = 15;
myChart.options.scales.y.ticks.stepSize = 1;
}
}
myChart.update();
},40);
setTimeout(function() {
context.drawImage(document.getElementById('myChart'), oldCanvas.width, textheight);
newCanvasReady = 2;
myChart.options.animation = true;
myChart.legend.options.display = false;
},80);
} else {
newCanvasReady = 2;
}
setTimeout(function() {
document.getElementById("shareimage").src = newCanvas.toDataURL();
//minitabswitch
if (complex_mode == 1) {
if (active_drug_set_index == 0) {
myChart.data.datasets[2].hidden=false;
myChart.data.datasets[3].hidden=false;
if (PD_mode>1) {
myChart.data.datasets[6].hidden=false;
myChart.data.datasets[7].hidden=false;
myChart.data.datasets[8].hidden=true;
myChart.data.datasets[9].hidden=true;
} else if (PD_mode == 1) {
myChart.data.datasets[10].hidden=false;
myChart.data.datasets[11].hidden=false;
}
myChart.data.datasets[4].hidden=true;
myChart.data.datasets[5].hidden=true;
myChart.update();
} else {
myChart.data.datasets[2].hidden=true;
myChart.data.datasets[3].hidden=true;
if (PD_mode>1) {
myChart.data.datasets[6].hidden=true;
myChart.data.datasets[7].hidden=true;
myChart.data.datasets[8].hidden=false;
myChart.data.datasets[9].hidden=false;
} else if (PD_mode == 1) {
myChart.data.datasets[10].hidden=true;
myChart.data.datasets[11].hidden=true;
}
myChart.data.datasets[4].hidden=false;
myChart.data.datasets[5].hidden=false;
myChart.update();
}
}
},120);
//also update data-text
document.getElementById("sharedatatext").value = 'https://simtiva.app/view.html?P=' + LZString.compressToEncodedURIComponent(outputstring());
}
function cloneCanvas(oldCanvas, filename) {
console.log('entering clonecanvas');
//create a new canvas
context = newCanvas.getContext('2d');
context.clearRect(0,0,newCanvas.width,newCanvas.height);
var textcontent = outputscheme();
//trick to destroy chart tooltip
myChart.canvas.dispatchEvent(new Event("mouseout"));
//note: myChart is the javascript chart object, oldCanvas is the canvas object
var correctionfactor = oldCanvas.width/myChart.width;
var textsize = 12 * correctionfactor;
textheight = textcontent[0].length * textsize * 1.2 + textsize * 4;
if (textcontent.length>1) {
var textheight0 = textcontent[0].length * textsize * 1.2 + textsize * 4;
var textheight1 = textcontent[1].length * textsize * 1.2 + textsize * 4;
if (textheight1>textheight0) {
textheight = textheight1;
} else {
textheight = textheight0;
}
}
if (eventArray.length > 0) {
textheight2 = eventArray.length * textsize * 1.2 + textsize;
} else {
textheight2 = 0;
}
//set dimensions
newCanvas.width = oldCanvas.width;
if (textcontent.length>1) {
newCanvas.width = oldCanvas.width * 2;
}
newCanvas.height = oldCanvas.height + textheight + textheight2;
if (textcontent.length>1) {
//complex mode
//add isobologram
var isoCanvas = document.getElementById("myChart2");
newCanvas.height = newCanvas.height+isoCanvas.height;
if (!isDark) {
context.fillStyle = "white";
} else {
context.fillStyle = "black";
}
context.fillRect(0, 0, newCanvas.width, newCanvas.height);
context.drawImage(isoCanvas,0,newCanvas.height-isoCanvas.height);
//add isobologram legend
var isoText = "Isobologram Legend";
context.font = "bold " + textsize * 1.75 + "px SourceSans";
if (!isDark) {
context.fillStyle = "black";
} else {
context.fillStyle = "white";
}
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+textsize * 2.2);
context.font = textsize + "px SourceSans";
if (!isDark) {
context.fillStyle = "black";
} else {
context.fillStyle = "white";
}
isoText = "Probability of tolerance to laryngoscopy (PTOL) isoboles:";
y = textsize * (2.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "PTOL10 to PTOL90 isoboles are drawn";
y = textsize * (2.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "according to Bouillon interaction model;";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "These are the equi-effective CE-propofol and CE-opioid";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "value pairs to achieve the identical PD effect.";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
//add rows to explain the curve
isoText = "Infusion regimens in use are visualized by";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "plotting CE values over time, yielding a curve";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "that shows the past, present & future of hypnotic-";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "opioid interaction in the 2D space.";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "Grey dots: 1min intervals before/after current";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 +0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "Red dot: current CE of hypnotic/opioid";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 +0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
isoText = "Arrow: 20mins in the future";
y = textsize * (2.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 + 1.2 +0.5);
context.fillText(isoText, isoCanvas.width+20, newCanvas.height-isoCanvas.height+y);
//end add isobologram
} else {
//simple mode
if (!isDark) {
context.fillStyle = "white";
} else {
context.fillStyle = "black";
}
context.fillRect(0, 0, newCanvas.width, newCanvas.height);
context.drawImage(oldCanvas, 0, textheight);
}
//write text to top of the frame
context.font = "bold " + textsize * 1.75 + "px SourceSans";
if (!isDark) {
context.fillStyle = "black";
} else {
context.fillStyle = "white";
}
if ((filename != undefined) && (filename.length > 0)) {
if ((filename == "download") || (filename == "picture")) {
filename = "SimTIVA Simulation Result";
} else {
filename = filename + " (SimTIVA Result)";
}
} else {
if (document.getElementById("inputFileName").value == '') {
filename = "SimTIVA Simulation Result";
} else {
filename = document.getElementById("inputFileName").value + " (SimTIVA Result)";
}
}
context.fillText(filename,50,textsize * 2.2);
//apply the old canvas to the new one
context.font = textsize + "px SourceSans";
if (!isDark) {
context.fillStyle = "black";
} else {
context.fillStyle = "white";
}
var y = textsize * (2.2 + 1.2 + 0.5);
for (i=0; i<textcontent[0].length; i++) {
context.fillText(textcontent[0][i],50,y+textsize*1.2*i);
}
if (textcontent.length>1) {
//complex mode write text
//drop two lines because textcontent[0][0] and [1] are titles/patient info
y = y + textsize*2.4;
for (i=0; i<textcontent[1].length; i++) {
context.fillText(textcontent[1][i],oldCanvas.width+50,y+textsize*1.2*i);
}
}
//add events
if (eventArray.length>0) {
y = textheight + oldCanvas.height + 0.5 * textsize;
for (evarraycount = 0; evarraycount<eventArray.length; evarraycount++) {
context.fillText(
converttime(eventArray[evarraycount][0]) + " - " + eventArray[evarraycount][1],
50,
y+textsize*1.2*evarraycount
);
}
}
//add some remarks to picture
context.textAlign = "right";
context.fillText("SimTIVA Simulation Result", oldCanvas.width-50, textheight + textsize * 4);
context.fillText("From http://simtiva.app", oldCanvas.width-50, textheight + textsize * 5.2);
context.fillText("Time elapsed = " + converttime(time_in_s), oldCanvas.width-50, textheight + textsize * 6.4);
//context.fillText("Cp " + Math.round(getcp(time_in_s)*100)/100, oldCanvas.width-50, textheight + textsize * 7.6);
//context.fillText("Ce " + Math.round(getce(time_in_s)*100)/100, oldCanvas.width-50, textheight + textsize * 8.8);
//context.fillText("Inf rate " + Math.round(inf_rate_mls*100)/100, oldCanvas.width-50, textheight + textsize * 10);
context.fillText("Drug 1: " + drug_sets[0].drug_name, oldCanvas.width-50, textheight + textsize * 7.6);
if (textcontent.length>1) {
context.fillText("SimTIVA Simulation Result", oldCanvas.width*2-50, textheight + textsize * 4);
context.fillText("From http://simtiva.app", oldCanvas.width*2-50, textheight + textsize * 5.2);
context.fillText("Time elapsed = " + converttime(time_in_s), oldCanvas.width*2-50, textheight + textsize * 6.4);
//context.fillText("Cp " + Math.round(getcp(time_in_s)*100)/100, oldCanvas.width-50, textheight + textsize * 7.6);
//context.fillText("Ce " + Math.round(getce(time_in_s)*100)/100, oldCanvas.width-50, textheight + textsize * 8.8);
//context.fillText("Inf rate " + Math.round(inf_rate_mls*100)/100, oldCanvas.width-50, textheight + textsize * 10);
context.fillText("Drug 2: " + drug_sets[1].drug_name, oldCanvas.width*2-50, textheight+ textsize * 7.6);
}
//return the new canvas
return newCanvas;
}
//section: object parsing
function parseobject(input_uid,external,extObject) {
parseloading = 1;
document.getElementById("status").innerHTML = "Loading PK data...";
if (external == true) {
object = extObject;
} else {
if (input_uid != null) {
object = loadobject(input_uid);
} else {
object = readURL(); //else, read from URL
}
}
//determine complex mode and read params
if (typeof object.P_length == "number") {
complex_mode = 0;
console.log('complex mode 0');
parse_historyarray = object.P_hx;
} else {
complex_mode = 1;
console.log('complex mode 1');
parse_historyarray = object.P_hx[0];
parse_historyarray1 = object.P_hx[1];
createCharts(1);
}
d = object.P_d;
working_clock = object.P_time;
//read general params
//detect adult vs paedimode. position 6 is array for paedi mode.
if (typeof object.P_patient[6] == "number") {
paedi_mode = 0;
age = object.P_patient[6];
} else {
paedi_mode = 1;
ageunit = object.P_patient[6][1];
if (ageunit == "d") {
age = object.P_patient[6][0] / 365;
} else if (ageunit == "w") {
age = object.P_patient[6][0] / 52;
} else if (ageunit == "m") {
age = object.P_patient[6][0] / 12;
} else if (ageunit == "y") {
age = object.P_patient[6][0];
}
PMA = object.P_patient[6][2];
//also need to render the inputPMA because otherwise readmodel will result in error
document.getElementById("inputPMA").value=PMA;
}
height = object.P_patient[5];
if (!Array.isArray(object.P_patient[4])) {
mass = object.P_patient[4];
} else {
mass = object.P_patient[4][0];
AdjBW = object.P_patient[4][1];
useAdjBW = 1;
}
//drug_sets[0].infusate_concentration = object.P_patient[2];
//drug_sets[0].conc_units = object.P_patient[3];
//if (object.P_patient[8]!=undefined) drug_sets[0].infused_units = object.P_patient[8];
if (object.name != undefined) {
if (object.name.length>0) document.getElementById("top_subtitle2").innerHTML = object.name;
}
if (object.P_patient[7] === "Male") {
gender = 0;
} else {
gender = 1;
}
if (height>0) {
if (gender == 0)
{lbm = 1.1 * mass - 128 * (mass/height) * (mass/height);}
else
{lbm = 1.07 * mass - 148 * (mass/height) * (mass/height);}
} else {
}
if ((object.P_patient[0] == "Eleveld") && (object.P_patient[1] == "Remifentanil")) {
object.P_patient[0] = "Eleveld-Remifentanil";
}
if ((object.P_patient[0] == "Eleveld") && (complex_mode == 0)) {
if (object.P_patient[10] != undefined) {
if (object.P_patient[10] == 0) {
opioid = 0;
} else {
opioid = 1;
}
}
}
readmodel(object.P_patient[0],0);
if (object.P_patient[0]=="Shafer") {
if (object.P_patient[10] == 0) {
drug_sets[0].fentanyl_weightadjusted_flag = 0;
drug_sets[0].modeltext = `
Shafer (no coparameters) (Anesthesiology 1990;73(6):1091-1102) <br>
PK model adjusted for body weight using formulas by Shibutani (Anesthesiology 2004;101:603-13) <br>
vc = ${drug_sets[0].vc} <br>
v2 = 28.1 <br>
v3 = 228 <br>
k10 = ${drug_sets[0].k10} <br>
k12 = ${drug_sets[0].k12} <br>
k13 = ${drug_sets[0].k13} <br>
k21 = ${drug_sets[0].k21} <br>
k31 = ${drug_sets[0].k31} <br>
ke0 = ${drug_sets[0].k41} <br>
ke0 derived from t1/2ke0 of 6.6min (Scott & Stanski, Anesthesiology 1991;74:34042)
`;
} else {
drug_sets[0].fentanyl_weightadjusted_flag = 1;
drug_sets[0].fentanyl_weightadjusted_factor = object.P_patient[11] * 1;
drug_sets[0].modeltext = `
Shafer (Anesthesiology 1990;73(6):1091-1102) <br>
PK model adjusted for body weight using formulas by Shibutani (Anesthesiology 2004;101:603-13) <br>
vc = ${drug_sets[0].vc} <br>
v2 = 28.1 <br>
v3 = 228 <br>
k10 = ${drug_sets[0].k10} <br>
k12 = ${drug_sets[0].k12} <br>
k13 = ${drug_sets[0].k13} <br>
k21 = ${drug_sets[0].k21} <br>
k31 = ${drug_sets[0].k31} <br>
ke0 = ${drug_sets[0].k41} <br>
ke0 derived from t1/2ke0 of 6.6min (Scott & Stanski, Anesthesiology 1991;74:34042)
`;
}
document.getElementById("modeldescription").innerHTML = drug_sets[0].modeltext;
}
//drug_sets[0].drug_name = object.P_patient[1];
if (object.P_patient[9]!=undefined) drug_sets[0].infusate_concentration = object.P_patient[9];
if ((object.P_patient[0] === "Minto") || (object.P_patient[0] === "Eleveld-Remifentanil")) {
document.getElementById("drugname").innerHTML = "Remifentanil <span style='opacity:0.5'>(" + drug_sets[0].infusate_concentration + "mcg/ml)</span>";
}
if (object.P_patient[0] === "Shafer") {
document.getElementById("drugname").innerHTML = "Fentanyl <span style='opacity:0.5'>(" + drug_sets[0].infusate_concentration + "mcg/ml)</span>";
}
if (object.P_patient[0] === "Maitre") {
document.getElementById("drugname").innerHTML = "Alfentanil <span style='opacity:0.5'>(" + drug_sets[0].infusate_concentration + "mcg/ml)</span>";
}
//from initcpt etc
drug_sets[0].cpt_active = 0.5;
drug_sets[0].firstrun = -1;
calculate_udfs(0);
drug_sets[0].p_state = new Array();
drug_sets[0].e_state = new Array();
// initialize params
drug_sets[0].cpt_rates = new Array();
drug_sets[0].cpt_times = new Array();
drug_sets[0].cpt_cp = new Array();
drug_sets[0].cpt_ce = new Array();
drug_sets[0].cpt_rates_real = new Array();
drug_sets[0].volinf = new Array();
drug_sets[0].historyarray = new Array();
drug_sets[0].historyarrays = new Array();
drug_sets[0].historytexts = new Array();
drug_sets[0].cpt_bolus = 0;
drug_sets[0].cet_bolus = 0;
drug_sets[0].cpt_pause = 0;
drug_sets[0].p_state = new Array();
drug_sets[0].e_state = new Array();
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
//l1 = Math.exp(-lambda[1] );
//l2 = Math.exp(-lambda[2] );
//l3 = Math.exp(-lambda[3] );
//l4 = Math.exp(-lambda[4] );
document.getElementById("status").innerHTML = "Loading simulation data...";
//assume this is simple mode
if (complex_mode == 0) {
if (((object.P_patient[0] == "Marsh") || (object.P_patient[0] == "Schnider")) && height>0) {
//emulate on
document.getElementById("emulatecard").style.display = "block";
} else {
document.getElementById("emulatecard").style.display = "none";
}
}
if (parse_historyarray[0][0] == 1) { // CPT mode
mode = "CPT mode";
for (count=0; count<parse_historyarray.length; count++) {
if (parse_historyarray[count][1] == 0) { //this is desired
time_in_s = parse_historyarray[count][2];
if (count > 0) {
result = getcp(time_in_s,0);
result_e = getce(time_in_s,0);
console.log("states retrieved, time " + time_in_s);
historydivs = document.getElementById("historywrapper").querySelectorAll("[data-time]");
if (parse_historyarray[count][3]>0) {
if (parse_historyarray[count].length>4) {
//normal CPT target array has 4 items, the fifth will denote the max rate
drug_sets[0].max_rate = parse_historyarray[count][4];
deliver_cpt(parse_historyarray[count][3],0,0,0);
} else {
drug_sets[0].max_rate = 0;
deliver_cpt(parse_historyarray[count][3],0,0,0); //for cpt mode effect flag is 0, third param is for compen, 4th param is drug_set
}
} else {
pauseCpt(0);
}
} else {
if (parse_historyarray[count][3]>0) {
if (parse_historyarray[count].length>4) {
drug_sets[0].max_rate = parse_historyarray[count][4];
deliver_cpt(parse_historyarray[count][3],0,0,0);
} else {
drug_sets[0].max_rate = 0;
deliver_cpt(parse_historyarray[count][3],0,0,0); //for cpt mode effect flag is 0
}
} else {
pauseCpt(0);
}
drug_sets[0].firstrun=0;
drug_sets[0].running=1;
}
}
}
document.getElementById("pastscheme").classList.add("show");
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("historywrapperCOPY").innerHTML = document.getElementById("historywrapper").innerHTML;
}
if (parse_historyarray[0][0] == 2) { //CET mode or IB mode
if (parse_historyarray[0][4] == 1) { //IB mode active
mode = "Intermittent Bolus";
//additional cet bolus params
drug_sets[0].cpt_active = 0;
drug_sets[0].cet_active = 0.5;
drug_sets[0].IB_active = 1;
drug_sets[0].IB_swing = 0.05;
drug_sets[0].firstrun = -1;
drug_sets[0].cpt_pause = 0;
drug_sets[0].cet_pause = 0;
drug_sets[0].cet_lockdowntime = 0;
for (count=0; count<parse_historyarray.length; count++) {
if (parse_historyarray[count][1] == 0) {
drug_sets[0].desired = 0;
drug_sets[0].IB_swing = parse_historyarray[count][5];
drug_sets[0].IB_active = 1;
drug_sets[0].firstrun = 0;
drug_sets[0].running = 1;
time_in_s = parse_historyarray[count][2];
if (count > 0) {
result = getcp(time_in_s,0);
result_e = getce(time_in_s,0);
console.log("states retrieved, time " + time_in_s);
historydivs = document.getElementById("historywrapper").querySelectorAll("[data-time]");
if (parse_historyarray[count][3]>0) {
deliver_cet_alt(parse_historyarray[count][3],0);
} else {
pauseCpt(0);
}
} else {
if (parse_historyarray[count][3]>0) {
deliver_cet_alt(parse_historyarray[count][3],0);
} else {
pauseCpt(0);
}
drug_sets[0].firstrun=0;
drug_sets[0].running=1;
}
}
}
document.getElementById("pastscheme").classList.add("show");
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("historywrapperCOPY").innerHTML = document.getElementById("historywrapper").innerHTML;
} else { //normal CET mode
mode = "CET mode";
//in addition, add CET init params
drug_sets[0].cpt_active = 0;
drug_sets[0].cet_active = 0.5;
drug_sets[0].IB_active = 0;
drug_sets[0].cpt_pause = 0;
drug_sets[0].cet_pause = 0;
drug_sets[0].cet_lockdowntime = 0;
for (count=0; count<parse_historyarray.length; count++) {
if (parse_historyarray[count][1] == 0) {
drug_sets[0].desired = 0;
drug_sets[0].firstrun = 0;
drug_sets[0].running = 1;
time_in_s = parse_historyarray[count][2];
if (count > 0) {
result = getcp(time_in_s,0);
result_e = getce(time_in_s,0);
console.log("states retrieved, time " + time_in_s);
historydivs = document.getElementById("historywrapper").querySelectorAll("[data-time]");
if (parse_historyarray[count][3]>0) {
if (parse_historyarray[count].length>4) {
drug_sets[0].max_rate = parse_historyarray[count][4];
deliver_cet(parse_historyarray[count][3],0);
} else {
drug_sets[0].max_rate = 0;
deliver_cet(parse_historyarray[count][3],0);
}
} else {
pauseCpt(0);
}
} else {
if (parse_historyarray[count][3]>0) {
if (parse_historyarray[count].length>4) {
drug_sets[0].max_rate = parse_historyarray[count][4];
deliver_cet(parse_historyarray[count][3],0);
} else {
drug_sets[0].max_rate = 0;
deliver_cet(parse_historyarray[count][3],0);
}
} else {
pauseCpt(0);
}
//firstrun=0;
//running=1;
}
}
}
document.getElementById("pastscheme").classList.add("show");
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("historywrapperCOPY").innerHTML = document.getElementById("historywrapper").innerHTML;
}
}
if (parse_historyarray[0][0] == 0) { //manual mode
mode = "Manual mode";
//extra params init
drug_sets[0].cpt_active = 0;
drug_sets[0].historytext = "";
drug_sets[0].desired = 0;
for (count = 0; count<parse_historyarray.length; count++) {
if (count == 0) {
drug_sets[0].firstrun = 0;
drug_sets[0].running = 1;
drug_sets[0].manualmode_active =1;
//special code to account for "lost time" for delayed start in complex mode
if (complex_mode == 1) {
time_in_s = parse_historyarray[count][2];
working_clock = Math.floor(time_in_s);
for (i=0; i<working_clock; i++) {
drug_sets[0].cpt_rates_real.push(0);
drug_sets[0].cpt_cp.push([0,0,0]);
drug_sets[0].cpt_ce.push([0,0,0,0]);
drug_sets[0].volinf.push(0)
}
myChart.data.datasets[2].data.push({x:(working_clock-1)/60, y:0});
myChart.data.datasets[3].data.push({x:(working_clock-1)/60, y:0});
}
}
console.log(count);
if (parse_historyarray[count][1] == 1) { //this is bolus
if (count+2 < parse_historyarray.length) { //this is not last
duration = parse_historyarray[count+2][2] + 180;
} else {
duration = parse_historyarray[count][2] + 21600;
}
time_in_s = parse_historyarray[count][2];
console.log("now is " + time_in_s);
drug_sets[0].inf_rate_mls = parse_historyarray[count+1][3];
parsebolusadmin(parse_historyarray[count][3],0);
lookahead(1,duration,0);
console.log("infusingafterbolus");
}
if (count>0) {
if (parse_historyarray[count-1][1] == 1) { //bolus just given
console.log("bolusskip");
} else if (parse_historyarray[count][1] == 2) { // this is infusion and not after a bolus
if (count+1 < parse_historyarray.length) { //this is not last
duration = parse_historyarray[count+1][2] + 180;
} else {
duration = parse_historyarray[count][2] + 21600;
}
time_in_s = parse_historyarray[count][2];
drug_sets[0].inf_rate_mls = parse_historyarray[count][3];
lookahead(0,duration,0);
console.log("infusing");
}
}
if ((count == 0) && (parse_historyarray[count][1] == 2)) {
if (count+1 < parse_historyarray.length) { //this is last
duration = parse_historyarray[count+1][2] + 180;
} else {
duration = parse_historyarray[count][2] + 21600;
}
drug_sets[0].inf_rate_mls = parse_historyarray[count][3];
lookahead(0,duration,0);
console.log("infusing");
}
}//end for loop
document.getElementById("historywrapper").innerHTML = drug_sets[0].historytext;
document.getElementById("schemecopytitle").innerHTML = "HISTORY";
document.getElementById("pastschemeCOPY").style.display = "none";
document.getElementById("historywrapperCOPY").innerHTML = document.getElementById("historywrapper").innerHTML;
}//end manual
//add complex mode parsing block
if (complex_mode == 1) {
active_drug_set_index = 1;
//need special precaution for eleveld-remifentanil?
readmodel(object.P_patient[10],1);
if (object.P_patient[10]=="Shafer") {
//from proceedcomplex
document.querySelector(".druglabelicon.opioid").innerText = "F";
document.querySelector(".druglabeltext.opioid>.line1").innerText = "FENTANYL";
myChart.data.datasets[4].label = 'Cp-Fen';
myChart.data.datasets[5].label = 'Ce-Fen';
myChart2.options.scales.x.title.text = 'Fentanyl Ce (ng/ml)';
//transform chart2 x axis
for (count1 = 0; count1<9; count1++) {
for (count = 0; count<myChart2.data.datasets[count1+11].data.length; count++) {
myChart2.data.datasets[count1+11].data[count].x *= 1/2.3;
}
}
myChart2.options.scales.x.max = 4;
myChart2.options.scales.x.ticks.stepSize = '0.5';
if (object.P_patient[15] == 0) {
drug_sets[1].fentanyl_weightadjusted_flag = 0;
drug_sets[1].modeltext = `
Shafer (no coparameters) (Anesthesiology 1990;73(6):1091-1102) <br>
PK model adjusted for body weight using formulas by Shibutani (Anesthesiology 2004;101:603-13) <br>
vc = ${drug_sets[1].vc} <br>
v2 = 28.1 <br>
v3 = 228 <br>
k10 = ${drug_sets[1].k10} <br>
k12 = ${drug_sets[1].k12} <br>
k13 = ${drug_sets[1].k13} <br>
k21 = ${drug_sets[1].k21} <br>
k31 = ${drug_sets[1].k31} <br>
ke0 = ${drug_sets[1].k41} <br>
ke0 derived from t1/2ke0 of 6.6min (Scott & Stanski, Anesthesiology 1991;74:34042)
`;
} else {
drug_sets[1].fentanyl_weightadjusted_flag = 1;
drug_sets[1].fentanyl_weightadjusted_factor = object.P_patient[16] * 1;
drug_sets[1].modeltext = `
Shafer (Anesthesiology 1990;73(6):1091-1102) <br>
PK model adjusted for body weight using formulas by Shibutani (Anesthesiology 2004;101:603-13) <br>
vc = ${drug_sets[1].vc} <br>
v2 = 28.1 <br>
v3 = 228 <br>
k10 = ${drug_sets[1].k10} <br>
k12 = ${drug_sets[1].k12} <br>
k13 = ${drug_sets[1].k13} <br>
k21 = ${drug_sets[1].k21} <br>
k31 = ${drug_sets[1].k31} <br>
ke0 = ${drug_sets[1].k41} <br>
ke0 derived from t1/2ke0 of 6.6min (Scott & Stanski, Anesthesiology 1991;74:34042)
`;
}
}//end shafer