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main.js
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main.js
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var initiated = false;
var umami;
var complex_mode = 0;
var paedi_mode = 0;
var PMA;
var ageunit = "y";
var active_drug_set_index = 0;
var alt_drug_set_index = 1;
var vc;
var d = null; //to store date object
var mass;
var ABW; //for eleveld
var lbm, height, gender;
var ibw, AdjBW;
var useAdjBW = 0;
var bmi;
var conc1;
var conc2;
var conc3;
var drug_sets = new Array();
var drug_name = "Propofol";
var conc_units = "mcg";
var infused_units = "mg";
var k10;
var k12;
var k21;
var k13;
var k31;
var k41;
var l1, l2, l3, l4;
var bolus;
var time = 0; //time in ms
var time_in_s = 0;
var r = new Array();
var lambda = new Array();
var refresh_interval = 1000; //interval for drug infusions
var inf_rate_mls;
//var inf_rate_mgperkg; //deprecated
var inf_rate_permass;
var inf_rate_permass_factor = 1; //1 for propofol
var inf_rate_permass_unit = "mg/kg/h";
var inf_rate_permass_dp = 100; //100 means 2 dp, if need zero dp, set this to 1
var inf_rate_amt;
var infusate_concentration=10;
var delta_volume_infused;
var delta_amount_infused;
var infuse_time;
var prior_infuse_time = -1;
var interval;
var volume_infused = 0;
var pump_rate_in_amt = 0;
var p_coef = new Array();
var e_coef = new Array();
var p_udf = new Array();
var e_udf = new Array();
var delta_seconds = 1; // for p_udf
var p_state = new Array();
var e_state = new Array();
var p_state2 = new Array();
var e_state2 = new Array();
var p_state3 = new Array();
var e_state3 = new Array();
var timeadjust = 0;
var loop1;
var loop2;
var firstrun = -1;
var result = 0;
var result_e = 0;
var alt_result = 0;
var alt_result_e = 0;
var simspeed =1;
var corX=0; //for chartjs
var corY=0; //for chartjs
var historytext = ""; //for history writing
var modeltext = " "; //for modeldescription
var myChart, myChart2, myChartEmulate;
var desired;
var cpt_threshold_auto =1;
var cpt_threshold=0.08;
var cpt_avgfactor=0.667;
var cpt_active = 0;
var cet_active = 0;
var IB_active = 0;
var IB_last_dose = 0;
var IB_last_time = 0;
var IB_next_dose = 0;
var IB_next_time = 0;
var manualmode_active = 0;
var running = 0;
var trial_result = 0;
var trial_result_e = 0;
var cpt_bolus = 0;
var cet_bolus = 0;
var cpt_rates = new Array();
var cpt_rates_real = new Array();
var cpt_times = new Array();
var cpt_cp = new Array();
var cpt_ce = new Array();
var volinf = new Array();
//fentanyl shibutani weight adjusted
//var fentanyl_weightadjusted_factor = 1;
//var fentanyl_weightadjusted_flag = 0;
//var fentanyl_weightadjusted_target_uncorrected = 0;
var cpt_rates_real_PP = new Array();
var cpt_cp_PP = new Array();
var cpt_ce_PP = new Array();
var cpt_interval = 120;//cpt interval
//for ce targeting
var peak_time, prior_peak_time;
var temp_peak, current, next_time;
var cet_lockdowntime = 0; //this will allow any cet_bolus to exert its full effect before going to new scheme of new target
var cet_priordesired = 0;
var historyarray = new Array();
// this is for current scheme
var historyarrays = new Array();
/* history arrays structure: this is for record keeping of all schemes entered
[a0,a1,a2,a3,a4,a5]
where
a0 = 0:manual, 1:cpt, 2:cet
a1 = 0:target, 1:bolus, 2:infusion arrays, 3:cetpause, 4:intermittent bolus arrays
a2 = time in s
a3 = content
added a5, a6 below to determine IB mode
a4 = IB mode active
a5 = IB swing
structure end */
var historydivs = new Array();
var prior = 0; //this is for update -->display-->highlight current inf rate
var next = 999; //this is for update -->display highlighting function when next is near
var preview_bolus;
var preview_rate;
var preview_downtrend;
var previewtimeout;
var user_hide=0; // for warning prompt - NOT hide by default
var timeout2 = null; // for delay display cpt prompt
var optionsarray = new Array();
var optionsarray_infusionunit = new Array();
var PD_mode = 0 ; //PD effect estimtation: 0 is off, 1 is BIS, 2 is PTOL, 3 is NSRI
var alert_vibrate_on = 0;
var alert_sound_on = 0;
var alertinterval_vibrate = null; //for alert api use - it is a setinterval function
var alertinterval_sound = null; //for alert api use - it is a setinterval function
var alert_sound_object = new sound("beep.mp3");
var alert_sound_object2 = new sound("beep-2.mp3");
var historytexts = new Array();
var chartprofile = 0;
var arrPOINTERS = new Array();
var arrTEMP = new Array();
var IB_swing = 0.05; //this is intermittent bolus swing
var PP_mode;
var PP_tickertime;
var PP_interval=180;
var PP_start = 0;
var PP_next = PP_interval;
var PP_temp_bolus_store = 0;
var PP_temp_bolustime_store = 0;
var ticker_active = 0;
var notificationallowed = 0;
var notificationactive = 0;
var UI_borderon = 0;
var UI_infrateon = 0;
var manageFileListState = 0;
var modal = undefined;
var prior_half_minute_clock = 0;
var time_of_stop = -1;
var yxratio; //for use in myChart2 to calculate angle of arrow
window.ptolcouplesarray = []; //ptol couples over time
//var ptol0overtime = new Array(); //ptol chart data for 0 over time, series based on chart data
//var ptol1overtime = new Array(); //ptol chart data for 1 over time
var loop6 = null; //this is setinterval function
var loop7 = null;
window.BIS_array = [];
window.eventArray = [];
const arrBodyIcons = [
["baby","<i class='fas fa-baby fa-fw tooltip bodyicon'><span class='tooltiptext'>BMI-for-age reference range from WHO</span></i>"],
["child","<i class='fas fa-child fa-fw tooltip bodyicon'><span class='tooltiptext'>BMI-for-age & weight-for-age reference range from WHO</span></i>"],
["male","<i class='fas fa-male fa-fw tooltip bodyicon'><span class='tooltiptext'>BMI reference range from WHO</span></i>"],
["female","<i class='fas fa-female fa-fw tooltip bodyicon'><span class='tooltiptext'>BMI reference range from WHO</span></i>"]
]
// variables for loading and saving
var uid;
//for local storage: data structure
//UID + "DATA" - target data
//UID + "PATIENT" - demographic and model
//UID + "TIME" - frequently changing time variable
var selected_uid;
var texttimeout = null;
// start service worker code
var parseloading = 0; //suppress function calls during parseobject loading when equals 1
var popupon = false;
var emulateOn = false;
var isDark = false;
var timeoutptol = null;
var chartviewarray = [0,30,10];
var ringbell2active = 0;
var ringbell2timeout = null;
var alert_sound_2 = null;
var alert_vibrate_2 = null;
var updateBIS = null;
var timeoutVal = null;
var ringtimeout = null;
var ringactive = 0;
var inputname = "";
var importDataArray = new Array();
var canvasUpdateInterval = null;
var textheight = 0;
var newCanvas = document.createElement('canvas');
var newCanvasReady = 0;
var popupchart;
var boxesArray = new Array();
var suitableForBoxes = false;
var isFullscreen = false;
var popupUpdateInterval;
var numpadValue = 0;
var numpadOrig;
var opioid = 1; //arbitrary default opioid = 1 for eleveld. to be re-set to 0 or 1 at first input screen
function toggleCard(x) {
var content = x.nextElementSibling;
x.classList.toggle("active");
if (content.style.display === "block") {
content.style.display = "none";
//content.classList.add("collapsed");
content.classList.remove("animate");
} else {
content.style.display = "block";
content.classList.add("animate");
}
}
var tops = document.getElementsByClassName("top_title_box");
for (i=0; i<tops.length; i++) {
tops[i].addEventListener("click", function() {
window.scrollTo(0,0);
})
}
//global colors / charting script initiation
//band colors from column 200 of material design 1-10 hues, for myChart2
var bandColor0 = 'rgb(239,154,154,0.2)';//red
var bandColor1 = 'rgb(244,143,177,0.2)';//pink
var bandColor2 = 'rgb(206,147,216,0.2)';//purple
var bandColor3 = 'rgb(179,157,219,0.2)';
var bandColor4 = 'rgb(159,168,218,0.2)';
var bandColor5 = 'rgb(144,202,249,0.2)';
var bandColor6 = 'rgb(129,212,250,0.2)';
var bandColor7 = 'rgb(128,222,234,0.2)';
var bandColor8 = 'rgb(128,203,196,0.2)';
var bandColor9 = 'rgb(165,214,167,0.2)';
var bandColor10 = 'rgb(197,225,165,0.2)';
var bandColor11 = 'rgb(230,238,156,0.2)';//lime
var bandColor12 = 'rgb(255,245,157,0.2)';//yellow
var bandColor13 = 'rgb(255,224,130,0.2)';//amber
var bandColor14= 'rgb(255,204,128,0.2)'//orange
var dotColor0 = 'rgb(158,158,158,1)';
var dotColor1 = 'rgb(117,117,117,1)';
var dotColor2 = 'rgb(97,97,97,1)';
var dotColor3 = 'rgb(66,66,66,1)';
var dotColor4 = 'rgb(33,33,33,1)';
var dotColor5 = 'rgb(66,66,66,1)';
var dotColor6 = 'rgb(97,97,97,1)';
var dotColor7 = 'rgb(117,117,117,1)';
var dotColor8 = 'rgb(158,158,158,1)';
var dotColor0dark = 'rgb(185,185,185,0.7)';
var dotColor1dark = 'rgb(200,200,200,0.8)';
var dotColor2dark = 'rgb(215,215,215,0.8)';
var dotColor3dark = 'rgb(230,230,230,0.8)';
var dotColor4dark = 'rgb(245,245,245,1)';
var dotColor5dark = 'rgb(230,230,230,0.8)';
var dotColor6dark = 'rgb(215,215,215,0.8)';
var dotColor7dark = 'rgb(200,200,200,0.8)';
var dotColor8dark = 'rgb(185,185,185,0.7)';
/*
const dotColor0 = 'rgb(0,96,100,1)'//cyan
const dotColor1 = 'rgb(1,87,155,1)'; // lightblue
const dotColor2 = 'rgb(26,35,126,1)'; //indigo
const dotColor3 = 'rgb(74,20,140,1)'; //purple
const dotColor4 = 'rgb(183,28,28,1)';//red
const dotColor5 = 'rgb(230,81,0,1)';//orange
const dotColor6 = 'rgb(245,127,23,1)';//yellow
const dotColor7 = 'rgb(51,105,30,1)';//lightgreen
const dotColor8 = 'rgb(0,77,64,1)';//teal
*/
//line colors from blue-grey row
var lineColor0 = 'rgba(84,110,122,0.75)';
var lineColor1 = 'rgba(120,144,156,1)';
var lineColor1dark = 'rgba(210,235,250,1)';
var yellowPri = 'rgba(251,192,45,1)';
var yellowPri50 = 'rgba(251,192,45,0.58)';
var yellowPri10 = 'rgba(251,192,45,0.1)';
var yellowPri70 = 'rgba(251,192,45,0.7)';
var yellowPri30 = 'rgba(251,192,45,0.3)';
var yellowLight = 'rgba(255,242,99,1)';
var yellowLight10 = 'rgba(255,242,99,0.1)';
var yellowLight70 = 'rgba(255,242,99,0.7)';
var yellowDark = 'rgba(196,144,0,1)';
var yellowSec = 'rgba(255,202,40,1)';
var yellowSec10 = 'rgba(255,202,40,0.11)';
var yellowSecLight = 'rgba(255,253,97,1)';
var yellowSecDark = 'rgba(199,154,0,1)';
var orangeShadeLight = 'rgba(255,204,128,0.2)';
var orangeShadeDark = 'rgba(255,152,0,0.2)';
var bluePri = 'rgba(21,101,192,1)';
var bluePri50 = 'rgba(21,101,192,0.5)';
var blueLight = 'rgba(94,146,243,1)';
var blueLight10 = 'rgba(94,146,243,0.1)';
var blueLight70 = 'rgba(94,146,243,0.7)';
var blueLight50 = 'rgba(94,146,243,0.58)';
var blueDark = 'rgba(0,60,143,1)';
var blueSec = 'rgba(3,169,244,1)';
var blueSec10 = 'rgba(3,169,244,0.11)';
var blueSecLight = 'rgba(103,218,255,1)';
var blueSecDark = 'rgba(0,122,193,1)';
var blueShadeDark = 'rgba(3,169,244,0.2)';
var greenShade = 'rgba(102, 177, 105, 0.25)';
var greenShadeDark = 'rgba(102, 177, 105, 0.35)';
function getGradientRed(ctx, chartArea, scales) {
const gradientBgRed = ctx.createLinearGradient(chartArea.left, 0, chartArea.right, 0);
var position = (scales.x.getPixelForValue(time_in_s/60) - scales.x.getPixelForValue(scales.x.min)) / chartArea.width;
if (position<=0) position = 0;
if (position>=1) position = 1;
gradientBgRed.addColorStop(0, 'rgba(231,50,39,0.4)');
gradientBgRed.addColorStop(position, 'rgba(231,50,39,0.4)');
gradientBgRed.addColorStop(position, 'rgba(231,50,39,0.1');
gradientBgRed.addColorStop(1, 'rgba(231,50,39,0.1)');
return gradientBgRed;
}
function getGradientYellow(ctx, chartArea, scales) {
const gradientBgYellow = ctx.createLinearGradient(chartArea.left, 0, chartArea.right, 0);
var position = (scales.x.getPixelForValue(time_in_s/60) - scales.x.getPixelForValue(scales.x.min)) / chartArea.width;
if (position<=0) position = 0;
if (position>=1) position = 1;
gradientBgYellow.addColorStop(0, 'rgba(251,192,45,0.58)');
gradientBgYellow.addColorStop(position, 'rgba(251,192,45,0.58)');
gradientBgYellow.addColorStop(position, 'rgba(255,202,40,0.11)');
gradientBgYellow.addColorStop(1, 'rgba(255,202,40,0.11)');
return gradientBgYellow;
}
function getGradientBlue(ctx, chartArea, scales) {
const gradientBgBlue = ctx.createLinearGradient(chartArea.left, 0, chartArea.right, 0);
var position = (scales.x.getPixelForValue(time_in_s/60) - scales.x.getPixelForValue(scales.x.min)) / chartArea.width;
if (position<=0) position = 0;
if (position>=1) position = 1;
gradientBgBlue.addColorStop(0, 'rgba(94,146,243,0.58)');
gradientBgBlue.addColorStop(position, 'rgba(94,146,243,0.58)');
gradientBgBlue.addColorStop(position, 'rgba(3,169,244,0.11)');
gradientBgBlue.addColorStop(1, 'rgba(3,169,244,0.11)');
return gradientBgBlue;
}
function getGradientGreen(ctx, chartArea, scales) {
const gradientBgGreen = ctx.createLinearGradient(chartArea.left, 0, chartArea.right, 0);
var position = (scales.x.getPixelForValue(time_in_s/60) - scales.x.getPixelForValue(scales.x.min)) / chartArea.width;
if (position<=0) position = 0;
if (position>=1) position = 1;
gradientBgGreen.addColorStop(0, 'rgba(9,203,93,0.7)');
gradientBgGreen.addColorStop(position, 'rgba(9,203,93,0.7)');
gradientBgGreen.addColorStop(position, 'rgba(9,203,93,0.1');
gradientBgGreen.addColorStop(1, 'rgba(9,203,93,0.1)');
return gradientBgGreen;
}
//dark mode activation
if (localStorage.getItem("colourMode") == "dark") {
isDark = true;
var metaThemeColor = document.querySelector("meta[name=theme-color]");
metaThemeColor.setAttribute("content", "#000");
document.body.classList.add("dark");
document.getElementById("darkmodebutton").innerHTML = "<i class='fas fa-adjust fa-fw'></i>";
}
if ("serviceWorker" in navigator) {
window.addEventListener("load", function() {
navigator.serviceWorker
.register("/serviceworker.js")
.then(res => console.log("service worker registered"))
.catch(err => console.log("service worker not registered", err))
})
}
window.addEventListener("resize", function() {
setTimeout(alignEvents,600);
setTimeout(alignPtolLabels,600);
});
screen.orientation.addEventListener("change", (event) => {
setTimeout(updatechartview2,500); //workaround for chartjs background problem
})
//for tooltip destruction on touchend for mobile devices
document.addEventListener('touchend', function(event) {
if (event.target && event.target.tagName.toLowerCase() !== "canvas") {
if (popupon) {
popupchart.canvas.dispatchEvent(new Event("mouseout"));
} else {
if (myChart != undefined) {
myChart.canvas.dispatchEvent(new Event("mouseout"));
}
}
if (emulateOn) {
myChartEmulate.canvas.dispatchEvent(new Event("mouseout"));
}
}
})
function init() {
setmodal("modalInitial");
}
function initsubmit() {
//the validation function on clicking "proceed" on starting page 1
//new, arbitrarily set zero
let validateText = "";
drug_sets_index=0;
simspeed=1;
//initiate parameters;
mass = document.getElementById("inputBW").value *1;
height = document.getElementById("inputBH").value*1;
if (paedi_mode==0) {
age = document.getElementById("inputAge").value*1;
ElModel = document.getElementById("select_model");
document.getElementById("ptoltooltip").style.display = "none";
} else {
document.getElementById("ptoltooltip").style.display = "inline-block";
ageunit = document.getElementById("select_age_unit").value;
if (ageunit == "d") {
age = document.getElementById("inputAgePaedi").value*1 / 365;
} else if (ageunit == "w") {
age = document.getElementById("inputAgePaedi").value*1 / 52;
} else if (ageunit == "m") {
age = document.getElementById("inputAgePaedi").value*1 / 12;
} else if (ageunit == "y") {
age = document.getElementById("inputAgePaedi").value*1;
}
ElModel = document.getElementById("select_model_paedi");
}
if (document.getElementById("select_gender").value === "Male") {
gender = 0;
} else {
gender = 1;
}
if (height>0) {
document.getElementById("bh").innerHTML = height + "cm";
if (gender == 0)
{lbm = 1.1 * mass - 128 * (mass/height) * (mass/height);}
else
{lbm = 1.07 * mass - 148 * (mass/height) * (mass/height);}
} else {
document.getElementById("bh").innerHTML = "?";
}
if (paedi_mode == 0) {
if (age>=0) {
document.getElementById("age").innerHTML = age + "y";
} else {
document.getElementById("age").innerHTML = "?";
}
} else {
document.getElementById("age").innerHTML = document.getElementById("inputAgePaedi").value + ageunit;
if (document.getElementById("inputPMA").value*1>0) {
document.getElementById("age").innerHTML = document.getElementById("age").innerHTML +
" (PMA: " + document.getElementById("inputPMA").value + "w)";
}
}
//display elements
document.getElementById("bw").innerHTML = mass + "kg";
document.getElementById("gender").innerHTML = document.getElementById("select_gender").value;
//off chart legend
myChart.legend.options.display = false;
if (ElModel.value === "Complex") {
complex_mode = 1;
opioid = 1;
//interface change
document.getElementById("complexmodeselection0").style.display = "block";
document.getElementById("complexmodeselection1").style.display = "block";
document.getElementById("complexbuttons").style.display = "block";
document.getElementById("page2title").innerHTML = "Complex Mode Setup";
document.getElementById("modalScreen2").style.paddingTop = "5vw";
document.getElementById("modalScreen2content").style.width = "90vw";
document.getElementById("simplemodeselection").style.display = "none";
if (age<0 || age>=100) {
validateText = validateText.concat("Invalid age (accepted range >0 to <100y)" + "<br>");
document.getElementById("inputAge").value = "";
}
if (mass<=0 || mass>=200) {
validateText = validateText.concat("Invalid body weight (accepted range >0 to <200kg)" + "<br>");
document.getElementById("inputBW").value = "";
}
//change model selection options according to paedimode
if (paedi_mode == 0) {
document.getElementById("model_propofol").options[0].disabled = false;
document.getElementById("model_propofol").options[1].disabled = false;
document.getElementById("model_opioid").options[0].disabled = false;
document.getElementById("model_opioid").options[2].disabled = false;
document.getElementById("model_opioid").value = "Minto";
} else {
//off marsh, schnider
document.getElementById("model_propofol").options[0].disabled = true;
document.getElementById("model_propofol").options[1].disabled = true;
//off minto, shafer, alfen
document.getElementById("model_opioid").options[0].disabled = true;
document.getElementById("model_opioid").options[2].disabled = true;
document.getElementById("model_opioid").options[3].disabled = true;
//set eleveld remi default
document.getElementById("model_opioid").value = "Eleveld-Remifentanil";
}
myChart.options.scales.y.title.text = "Concentration (mcg/ml)";
//on complex interface displays
document.getElementById("ptolcard").style.display = "flex";
document.getElementById("ptolcardoptions").style.display = "block";
document.getElementById("interactionscontainer").style.display = "block";
document.getElementById("ptolcard_switch").style.display = "block";
PD_mode = 2;
document.getElementById("select_effect_measure").value = "ptol";
document.getElementById("chartoverlayoptionscontent").classList.add("PDoptions");
document.getElementById("select_effect_measure").disabled = false;
document.getElementById("ptoltitle").innerHTML = "PTOL";
document.getElementById("ptoldesc").innerHTML = "Probability of tolerance to laryngoscopy (%)";
myChart.data.datasets[10].backgroundColor = greenShade;
myChart.data.datasets[10].borderColor = greenShadeDark;
myChart.data.datasets[11].borderColor = greenShadeDark;
myChart.data.datasets[6].hidden = false;
myChart.data.datasets[7].hidden = false;
myChart.data.datasets[10].hidden = true;
myChart.data.datasets[11].hidden = true;
myChart.update();
} else {
complex_mode = 0;
//off complex interface displays
document.getElementById("ptolcard").style.display = "none";
document.getElementById("ptolcardoptions").style.display = "none";
document.getElementById("interactionscontainer").style.display = "none";
document.getElementById("ptolcard_switch").style.display = "none";
//interface change
document.getElementById("complexmodeselection0").style.display = "none";
document.getElementById("complexmodeselection1").style.display = "none";
document.getElementById("complexbuttons").style.display = "none";
if (ElModel.value == "Eleveld") {
if (document.getElementById("select_eleveldopioid").value == "1") {opioid = 1} else {opioid = 0};
}
readmodel(ElModel.value,0);
//infusate_concentration goes here
drug_sets[0].infusate_concentration = 10; //defaults 10 for propofol
//see if need to display emulation eleveld
if (((drug_sets[0].model_name == "Marsh") || (drug_sets[0].model_name == "Schnider")) && (height>0)) {
document.getElementById("emulatecard").style.display = "block";
} else {
document.getElementById("emulatecard").style.display = "none";
}
if ((paedi_mode == 0 && document.getElementById("select_model").value == "Eleveld") || (paedi_mode == 1 && document.getElementById("select_model_paedi").value == "Eleveld")) {
PD_mode = 1;
document.getElementById("chartoverlayoptionscontent").classList.add("PDoptions");
document.getElementById("select_effect_measure").value = "bis";
document.getElementById("select_effect_measure").disabled = true;
document.getElementById("ptoltitle").innerHTML = "eBIS";
document.getElementById("ptoldesc").innerHTML = "Estimated BIS from Eleveld PD model";
BIS40 = BIS_Ce_for_BIS(40);
BIS60 = BIS_Ce_for_BIS(60);
myChart.data.datasets[11].data = [{x:0, y:BIS60},{x:21600, y:BIS60}];
myChart.data.datasets[10].data = [{x:0, y:BIS40},{x:21600, y:BIS40}];
myChart.data.datasets[10].backgroundColor = yellowPri30;
myChart.data.datasets[10].borderColor = yellowPri50;
myChart.data.datasets[11].borderColor = yellowPri50;
myChart.data.datasets[6].hidden = true;
myChart.data.datasets[7].hidden = true;
myChart.data.datasets[10].hidden = false;
myChart.data.datasets[11].hidden = false;
myChart.update();
document.getElementById("ptolcard").style.display = "flex";
document.getElementById("ptoltitle").innerHTML = "eBIS";
document.getElementById("ptoldesc").innerHTML = "Estimated BIS from Eleveld PD model";
myChart.update();
} else {
myChart.data.datasets[10].hidden = true;
myChart.data.datasets[11].hidden = true;
myChart.update();
}
document.getElementById("modalScreen2").style.paddingTop = "";
document.getElementById("modalScreen2content").style.width = "";
document.getElementById("simplemodeselection").style.display = "";
if (paedi_mode == 0) {
if ((document.getElementById("select_model").value === "Minto") || (document.getElementById("select_model").value === "Eleveld-Remifentanil")) {
if (document.getElementById("select_remidilution").value == "custom") {
drug_sets[0].infusate_concentration = document.getElementById("remidilution").innerHTML *1;
} else {
drug_sets[0].infusate_concentration = document.getElementById("select_remidilution").value * 1;
}
}
} else {
if (document.getElementById("select_model_paedi").value === "Eleveld-Remifentanil") {
if (document.getElementById("select_remidilution").value == "custom") {
drug_sets[0].infusate_concentration = document.getElementById("remidilution").innerHTML *1;
} else {
drug_sets[0].infusate_concentration = document.getElementById("select_remidilution").value * 1;
}
}
}
if ((paedi_mode == 0) && (document.getElementById("select_model").value === "Shafer")) {
if (document.getElementById("select_fendilution").value == "custom") {
drug_sets[0].infusate_concentration = document.getElementById("fendilution").innerHTML *1;
} else {
drug_sets[0].infusate_concentration = document.getElementById("select_fendilution").value * 1;
}
if (select_fen_weightadjusted.value == "0") {
drug_sets[0].modeltext = `
Shafer (no coparameters) (Anesthesiology 1990;73(6):1091-1102) <br>
vc = ${drug_sets[0].vc} <br>
v2 = 28.1 <br>
v3 = 228 <br>
k10 = ${drug_sets[0].k10} <br>
k12 = ${drug_sets[0].k12} <br>
k13 = ${drug_sets[0].k13} <br>
k21 = ${drug_sets[0].k21} <br>
k31 = ${drug_sets[0].k31} <br>
ke0 = ${drug_sets[0].k41} <br>
ke0 derived from t1/2ke0 of 6.6min (Scott & Stanski, Anesthesiology 1991;74:34042)
`;
drug_sets[0].fentanyl_weightadjusted_flag = 0;
} else {
drug_sets[0].modeltext = `
Shafer (Anesthesiology 1990;73(6):1091-1102) <br>
PK model adjusted for body weight using formulas by Shibutani (Anesthesiology 2004;101:603-13) <br>
vc = ${drug_sets[0].vc} <br>
v2 = 28.1 <br>
v3 = 228 <br>
k10 = ${drug_sets[0].k10} <br>
k12 = ${drug_sets[0].k12} <br>
k13 = ${drug_sets[0].k13} <br>
k21 = ${drug_sets[0].k21} <br>
k31 = ${drug_sets[0].k31} <br>
ke0 = ${drug_sets[0].k41} <br>
ke0 derived from t1/2ke0 of 6.6min (Scott & Stanski, Anesthesiology 1991;74:34042)
`;
drug_sets[0].fentanyl_weightadjusted_factor = (1+(196.4*Math.exp(-0.025*mass)-53.66)/100);
drug_sets[0].fentanyl_weightadjusted_flag = 1;
}
document.getElementById("modeldescription").innerHTML = drug_sets[0].modeltext;
}
if ((paedi_mode ==0) && (document.getElementById("select_model").value == "Maitre")) {
if (document.getElementById("select_alfendilution").value == "custom") {
drug_sets[0].infusate_concentration = document.getElementById("alfendilution").innerHTML *1;
} else {
drug_sets[0].infusate_concentration = document.getElementById("select_alfendilution").value * 1;
}
document.querySelector("#bolus3>.bolus_inside").innerHTML = "300" + "<span class='infused_units'></span>";
document.querySelector("#bolus3").setAttribute("onclick","bolusadmin(300,0)");
document.querySelector("#bolus2>.bolus_inside").innerHTML = "200" + "<span class='infused_units'></span>";
document.querySelector("#bolus2").setAttribute("onclick","bolusadmin(200,0)");
document.querySelector("#bolus1>.bolus_inside").innerHTML = "100" + "<span class='infused_units'></span>";
document.querySelector("#bolus1").setAttribute("onclick","bolusadmin(100,0)");
}
if (paedi_mode == 0) {
if ((document.getElementById("select_model").value === "Minto") || (document.getElementById("select_model").value === "Eleveld-Remifentanil")) {
document.getElementById("drugname").innerHTML = "Remifentanil <span style='opacity:0.5'>(" + drug_sets[drug_sets_index].infusate_concentration + "mcg/ml)</span>";
document.getElementById("card_retrospective").style.display = "none";
document.getElementById("card_wakeup").style.display = "none";
}
} else {
if (document.getElementById("select_model_paedi").value === "Eleveld-Remifentanil") {
document.getElementById("drugname").innerHTML = "Remifentanil <span style='opacity:0.5'>(" + drug_sets[drug_sets_index].infusate_concentration + "mcg/ml)</span>";
document.getElementById("card_retrospective").style.display = "none";
document.getElementById("card_wakeup").style.display = "none";
}
}
if ((paedi_mode == 0) && (document.getElementById("select_model").value === "Shafer")) {
document.getElementById("drugname").innerHTML = "Fentanyl <span style='opacity:0.5'>(" + drug_sets[drug_sets_index].infusate_concentration + "mcg/ml)</span>";
document.getElementById("card_retrospective").style.display = "none";
document.getElementById("card_wakeup").style.display = "none";
}
if ((paedi_mode == 0) && (document.getElementById("select_model").value === "Maitre")) {
document.getElementById("drugname").innerHTML = "Alfentanil <span style='opacity:0.5'>(" + drug_sets[drug_sets_index].infusate_concentration + "mcg/ml)</span>";
document.getElementById("card_retrospective").style.display = "none";
document.getElementById("card_wakeup").style.display = "none";
}
var conc_units_fields = document.getElementsByClassName("conc_units");
for (i=0; i<conc_units_fields.length; i++) {
conc_units_fields[i].innerHTML = drug_sets[drug_sets_index].conc_units;
}
var infused_units_fields = document.getElementsByClassName("infused_units");
for (i=0; i<infused_units_fields.length; i++) {
infused_units_fields[i].innerHTML = drug_sets[drug_sets_index].infused_units;
}
if (drug_sets[0].drug_name == "Propofol") {
myChart.options.scales.y.title.text = "Concentration (mcg/ml)";
} else {
myChart.options.scales.y.title.text = "Concentration (ng/ml)";
}
if (age<0 || age>=100) {
validateText = validateText.concat("Invalid age (accepted range >0 to <100y)" + "<br>");
document.getElementById("inputAge").value = "";
}
if (mass<=0 || mass>=200) {
validateText = validateText.concat("Invalid body weight (accepted range >0 to <200kg)" + "<br>");
document.getElementById("inputBW").value = "";
}
if ((height<=0 || height>=250) && (ElModel.value=="Schnider" || ElModel.value=="Eleveld")) {
validateText = validateText.concat("Invalid body height (accepted range >0 to <250cm)" + "<br>");
document.getElementById("inputBH").value = "";
}
if (age<12 && (ElModel.value=="Marsh" || ElModel.value=="Schnider" || ElModel.value=="Minto" || ElModel.value=="Shafer" || ElModel.value=="Maitre")) {
validateText = validateText.concat("Invalid model: not suitable for children." + "<br>");
}
if (mass>=80 && ElModel.value=="Shafer") {
if (select_fen_weightadjusted.value == "0") {
validateText = validateText.concat("Warning: Original Shafer model not adjusted to body weight and not recommended for obese. Please select Weight Adjusted model." + "<br>");
}
}
if (age>15 && ElModel.value=="Paedfusor") {
validateText = validateText.concat("Invalid model: Paedfusor not suitable for adults." + "<br>");
}
if (document.getElementById("select_remidilution").value == "custom") {
temp = document.getElementById("remidilution").innerHTML * 1 ;
if (temp > 100 || temp < 0.1) {
validateText = validateText.concat("Invalid remifentanil dilution: must be within 0.1-100mcg/ml" + "<br>");
document.getElementById("select_remidilution").value = "20";
document.getElementById("custom_remidilution").style.display = "none";
}
}
if (document.getElementById("select_fendilution").value == "custom") {
temp = document.getElementById("fendilution").innerHTML * 1 ;
if (temp > 100 || temp < 0.1) {
validateText = validateText.concat("Invalid fentanyl dilution: must be within 0.1-100mcg/ml" + "<br>");
document.getElementById("select_fendilution").value = "10";
document.getElementById("custom_fendilution").style.display = "none";
}
}
if (document.getElementById("select_alfendilution").value == "custom") {
temp = document.getElementById("alfendilution").innerHTML * 1 ;
if (temp > 500 || temp < 0.1) {
validateText = validateText.concat("Invalid fentanyl dilution: must be within 0.1-500mcg/ml" + "<br>");
document.getElementById("select_alfendilution").value = "100";
document.getElementById("custom_alfendilution").style.display = "none";
}
}
var x = drug_sets[drug_sets_index].drug_name + " (" + ElModel.value + ")";
document.getElementById("page2title").innerHTML = x;
if ((ElModel.value == "Shafer") && (drug_sets[0].fentanyl_weightadjusted_flag == 1)) document.getElementById("page2title").innerHTML = "Fentanyl (Shafer: Weight adjusted)";
}
if (validateText != "") {
displayWarning("Invalid input",validateText);
return 1; //1=error
} else {
return 0; //0=proceed
}
}
function initcpt() {
document.getElementById("card_infusion0").style.display = "none";
document.getElementById("card_cet0").style.display = "none";
document.getElementById("card_cet0_new").style.display = "none";
document.getElementById("btn_displayhistory").innerHTML = "Scheme";
document.getElementById("status").innerHTML="Waiting to start";
drug_sets_index = 0;
drug_sets[drug_sets_index].cpt_active = 0.5;
drug_sets[drug_sets_index].firstrun = -1;
calculate_udfs(drug_sets_index);
drug_sets[drug_sets_index].p_state = new Array();
drug_sets[drug_sets_index].e_state = new Array();
// initialize params
drug_sets[drug_sets_index].cpt_rates = new Array();
drug_sets[drug_sets_index].cpt_times = new Array();
drug_sets[drug_sets_index].cpt_cp = new Array();
drug_sets[drug_sets_index].cpt_ce = new Array();
drug_sets[drug_sets_index].cpt_rates_real = new Array();
drug_sets[drug_sets_index].volinf = new Array();
drug_sets[drug_sets_index].historyarray = new Array();
drug_sets[drug_sets_index].historyarrays = new Array();
drug_sets[drug_sets_index].historytexts = new Array();
drug_sets[drug_sets_index].cpt_bolus = 0;
drug_sets[drug_sets_index].cet_bolus = 0;
drug_sets[drug_sets_index].cpt_pause = 0;
p_state[1] = 0;
p_state[2] = 0;
p_state[3] = 0;
e_state[1] = 0;
e_state[2] = 0;
e_state[3] = 0;
e_state[4] = 0;
//l1 = Math.exp(-lambda[1] );
//l2 = Math.exp(-lambda[2] );
//l3 = Math.exp(-lambda[3] );
//l4 = Math.exp(-lambda[4] );
}
function initshare() {
if (parseloading == 0) {
d = new Date(); //create date object and store in d
document.getElementById("sharebutton").style.display = "block";
document.getElementById("annotatebutton").style.display = "block";
document.getElementById("expandbutton").style.display = "block";
/*
document.getElementById("inputFileName").value = document.getElementById("inputFileName1").value;
*/
showInstallPromotion();
createfile();
savefile_patient();
}
}
function common_start_calls() {
document.getElementById("top_subtitle").classList.add("topClose");
document.getElementById("top_title").classList.add("topOpen");
loop1 = setInterval(update, 500);
if (complex_mode == 1) {
loop2 = setInterval(runinfusion_complex, refresh_interval);
} else {
loop2 = setInterval(runinfusion2, refresh_interval);
}
loop3 = setInterval(updatechart, 5000, myChart);
loop7 = setInterval(displayWarningBanner, 60*2000);
initshare();
trk();
}
var displaymode = '';
function getPWADisplayMode() {
if (document.referrer.startsWith('android-app://'))
return 'twa';
if (window.matchMedia('(display-mode: browser)').matches)
return 'net-browser';
if (window.matchMedia('(display-mode: standalone)').matches)
return 'PWA-standalone';
if (window.matchMedia('(display-mode: minimal-ui)').matches)
return 'PWA-minimal-ui';
if (window.matchMedia('(display-mode: fullscreen)').matches)
return 'PWA-fullscreen';
if (window.matchMedia('(display-mode: window-controls-overlay)').matches)
return 'PWA-window-controls-overlay';
return 'unknown';
}
window.addEventListener('DOMContentLoaded', () => {
// Log launch display mode to analytics
displaymode = getPWADisplayMode();
console.log(displaymode);
});
function trk() {
if (umami != undefined) {
//custom umami tracker function
trackerprops = {};
if (complex_mode == 0) {
temptext0 = 'Simple';
trackerprops.model = drug_sets[0].model_name;
if (drug_sets[0].cpt_active > 0) {
trackerprops.mode = 'CPT';
} else if (drug_sets[0].cet_active > 0) {
if (drug_sets[0].IB_active > 0) {
trackerprops.mode = 'IB';
} else {
trackerprops.mode = 'CET';
}
} else if (drug_sets[0].manualmode_active > 0) {
trackerprops.mode = 'Manual';
}
temptext = trackerprops.mode + trackerprops.model;
} else {
trackerprops.model = 'Complex';
temptext0 = 'Complex';
temptext = '';
if (drug_sets[0].cpt_active > 0) {
temptext += 'CPT';
} else if (drug_sets[0].cet_active > 0) {
if (drug_sets[0].IB_active > 0) {
temptext += 'IB';
} else {
temptext += 'CET';
}
} else if (drug_sets[0].manualmode_active > 0) {
temptext += 'Manual';
}
temptext += drug_sets[0].model_name;
temptext += ' + ';
if (drug_sets[1].cpt_active > 0) {
temptext += 'CPT';
} else if (drug_sets[1].cet_active > 0) {
if (drug_sets[1].IB_active > 0) {
temptext += 'IB';
} else {
temptext += 'CET';
}
} else if (drug_sets[1].manualmode_active > 0) {
temptext += 'Manual';
}
temptext += drug_sets[1].model_name;
trackerprops.mode = temptext;
}
//patient data
if (bmi != undefined) {
if (bmi<18.5) {
trackerprops.BMI = "<18.5";
} else if ((bmi>=18.5) && (bmi<25)) {
trackerprops.BMI = "normal";
} else if ((bmi>=25) && (bmi<29.9)) {
trackerprops.BMI = "25-30";
} else if ((bmi>30) && (bmi<35)) {
trackerprops.BMI = "30-35";
} else if ((bmi>=35) && (bmi<=9999)) {
trackerprops.BMI = ">35";
} else if (bmi == Infinity) {
trackerprops.BMI = "unknown";
} else {
trackerprops.BMI = "unknown";
}
}
if (age<3) {
trackerprops.age = "<3";
} else if ((age>=3) && (age<16)) {