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15.html
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<p><strong>Title:</strong> Therapeutic modulation of eIF2 α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models</p>
<p><strong>Year Published:</strong> 2013</p>
<p><strong>Observation:</strong> TDP43 accumulation in yeast colocalizes with PUB1. TDP43 expression in fly brain induces chronic eIF2alpha phosphorylation. PABP modulates TDP43 toxicity in drosophila and PABC1 is mislocalized in human ALS spinal cord MN </p>
<p><strong>Comment:</strong> Propose that compounds mitigating eIF2alpha phosphorylation could be developed as therapeutics for ALS</p>
<p><strong>Citation:</strong> Kim, H., Raphael, A. R., Ladow, E. S., Mcgurk, L., Weber, R. A., Trojanowski, J. Q., … Bonini, N. M. (2013). Therapeutic modulation of eIF2 α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Publishing Group, 46(2), 152–160. doi:10.1038/ng.2853</p>
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