test_full.xml

C:\Users\monar\AppData\Local\Programs\Python\Python39\python.exe C:\Users\monar\PycharmProjects\Haider_Review\test.py
<?xml version="1.0" encoding="UTF-8"  standalone="no" ?>
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  <accession>C5IFJ8</accession>
  <accession>D3DWF5</accession>
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  <accession>Q9UJ33</accession>
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      <fullName>Protein kinase C beta type</fullName>
      <shortName>PKC-B</shortName>
      <shortName>PKC-beta</shortName>
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    <name type="synonym">PKCB</name>
    <name type="synonym">PRKCB1</name>
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    <name type="scientific">Homo sapiens</name>
    <name type="common">Human</name>
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      <taxon>Eukaryota</taxon>
      <taxon>Metazoa</taxon>
      <taxon>Chordata</taxon>
      <taxon>Craniata</taxon>
      <taxon>Vertebrata</taxon>
      <taxon>Euteleostomi</taxon>
      <taxon>Mammalia</taxon>
      <taxon>Eutheria</taxon>
      <taxon>Euarchontoglires</taxon>
      <taxon>Primates</taxon>
      <taxon>Haplorrhini</taxon>
      <taxon>Catarrhini</taxon>
      <taxon>Hominidae</taxon>
      <taxon>Homo</taxon>
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  <reference key="1">
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      <dbReference type="PubMed" id="3755548"/>
      <dbReference type="DOI" id="10.1126/science.3755548"/>
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    <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-II)</scope>
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    <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA-I AND BETA-II)</scope>
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      <authorList>
        <consortium name="NIEHS SNPs program"/>
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    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
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      </authorList>
      <dbReference type="PubMed" id="10493829"/>
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    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
  </reference>
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    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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      <authorList>
        <consortium name="The MGC Project Team"/>
      </authorList>
      <dbReference type="PubMed" id="15489334"/>
      <dbReference type="DOI" id="10.1101/gr.2596504"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]</scope>
    <source>
      <tissue>Hippocampus</tissue>
    </source>
  </reference>
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      <authorList>
        <person name="Mahajna J."/>
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      </authorList>
      <dbReference type="PubMed" id="7880442"/>
      <dbReference type="DOI" id="10.1089/dna.1995.14.213"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69</scope>
  </reference>
  <reference key="8">
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        <person name="Niino Y.S."/>
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      </authorList>
      <dbReference type="PubMed" id="1556124"/>
      <dbReference type="DOI" id="10.1016/s0021-9258(18)42675-0"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58</scope>
  </reference>
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        <person name="Obeid L.M."/>
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      </authorList>
      <dbReference type="PubMed" id="1400396"/>
      <dbReference type="DOI" id="10.1016/s0021-9258(19)36758-4"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57</scope>
  </reference>
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      <dbReference type="PubMed" id="12665801"/>
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    <scope>PROTEIN SEQUENCE OF 2-19</scope>
    <scope>ACETYLATION AT ALA-2</scope>
    <source>
      <tissue>Platelet</tissue>
    </source>
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    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 97-176</scope>
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      <dbReference type="PubMed" id="3677994"/>
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    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 609-671</scope>
    <source>
      <tissue>Fetal brain</tissue>
    </source>
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      </authorList>
      <dbReference type="PubMed" id="3658678"/>
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    <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 622-671</scope>
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    <scope>FUNCTION IN PHOSPHORYLATION OF BTK</scope>
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      <dbReference type="PubMed" id="16103100"/>
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    <scope>ACTIVITY REGULATION</scope>
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      </authorList>
      <dbReference type="PubMed" id="18162466"/>
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    <scope>INTERACTION WITH PHLPP1 AND PHLPP2</scope>
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    <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
    <source>
      <tissue>Platelet</tissue>
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      <dbReference type="PubMed" id="19176525"/>
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    </citation>
    <scope>FUNCTION</scope>
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      <dbReference type="PubMed" id="19369195"/>
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    </citation>
    <scope>PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-504</scope>
    <scope>PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-641 AND SER-660 (ISOFORM BETA-II)</scope>
    <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
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    <scope>FUNCTION IN HISTONE H3 PHOSPHORYLATION</scope>
    <scope>CATALYTIC ACTIVITY</scope>
    <scope>SUBCELLULAR LOCATION</scope>
    <scope>INTERACTION WITH KDM1A; PKN1 AND AR</scope>
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    <scope>REVIEW ON FUNCTION</scope>
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    <scope>REVIEW ON FUNCTION</scope>
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    <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
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    <scope>PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; THR-17; SER-206; SER-311; THR-314 AND THR-642</scope>
    <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
    <source>
      <tissue>Erythroleukemia</tissue>
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      <dbReference type="PubMed" id="24275569"/>
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    <scope>PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-641 AND SER-660 (ISOFORM BETA-II)</scope>
    <scope>IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]</scope>
    <source>
      <tissue>Liver</tissue>
    </source>
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        <person name="Lee E.E."/>
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    <scope>FUNCTION</scope>
    <scope>CATALYTIC ACTIVITY</scope>
  </reference>
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    <citation type="journal article" date="2006" name="Biochemistry" volume="45" first="13970" last="13981">
      <title>Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.</title>
      <authorList>
        <person name="Grodsky N."/>
        <person name="Li Y."/>
        <person name="Bouzida D."/>
        <person name="Love R."/>
        <person name="Jensen J."/>
        <person name="Nodes B."/>
        <person name="Nonomiya J."/>
        <person name="Grant S."/>
      </authorList>
      <dbReference type="PubMed" id="17115692"/>
      <dbReference type="DOI" id="10.1021/bi061128h"/>
    </citation>
    <scope>X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 321-660 IN COMPLEX WITH INHIBITOR</scope>
    <scope>PHOSPHORYLATION AT THR-500; THR-642 AND SER-661</scope>
  </reference>
  <reference key="28">
    <citation type="journal article" date="2007" name="Nature" volume="446" first="153" last="158">
      <title>Patterns of somatic mutation in human cancer genomes.</title>
      <authorList>
        <person name="Greenman C."/>
        <person name="Stephens P."/>
        <person name="Smith R."/>
        <person name="Dalgliesh G.L."/>
        <person name="Hunter C."/>
        <person name="Bignell G."/>
        <person name="Davies H."/>
        <person name="Teague J."/>
        <person name="Butler A."/>
        <person name="Stevens C."/>
        <person name="Edkins S."/>
        <person name="O'Meara S."/>
        <person name="Vastrik I."/>
        <person name="Schmidt E.E."/>
        <person name="Avis T."/>
        <person name="Barthorpe S."/>
        <person name="Bhamra G."/>
        <person name="Buck G."/>
        <person name="Choudhury B."/>
        <person name="Clements J."/>
        <person name="Cole J."/>
        <person name="Dicks E."/>
        <person name="Forbes S."/>
        <person name="Gray K."/>
        <person name="Halliday K."/>
        <person name="Harrison R."/>
        <person name="Hills K."/>
        <person name="Hinton J."/>
        <person name="Jenkinson A."/>
        <person name="Jones D."/>
        <person name="Menzies A."/>
        <person name="Mironenko T."/>
        <person name="Perry J."/>
        <person name="Raine K."/>
        <person name="Richardson D."/>
        <person name="Shepherd R."/>
        <person name="Small A."/>
        <person name="Tofts C."/>
        <person name="Varian J."/>
        <person name="Webb T."/>
        <person name="West S."/>
        <person name="Widaa S."/>
        <person name="Yates A."/>
        <person name="Cahill D.P."/>
        <person name="Louis D.N."/>
        <person name="Goldstraw P."/>
        <person name="Nicholson A.G."/>
        <person name="Brasseur F."/>
        <person name="Looijenga L."/>
        <person name="Weber B.L."/>
        <person name="Chiew Y.-E."/>
        <person name="DeFazio A."/>
        <person name="Greaves M.F."/>
        <person name="Green A.R."/>
        <person name="Campbell P."/>
        <person name="Birney E."/>
        <person name="Easton D.F."/>
        <person name="Chenevix-Trench G."/>
        <person name="Tan M.-H."/>
        <person name="Khoo S.K."/>
        <person name="Teh B.T."/>
        <person name="Yuen S.T."/>
        <person name="Leung S.Y."/>
        <person name="Wooster R."/>
        <person name="Futreal P.A."/>
        <person name="Stratton M.R."/>
      </authorList>
      <dbReference type="PubMed" id="17344846"/>
      <dbReference type="DOI" id="10.1038/nature05610"/>
    </citation>
    <scope>VARIANTS [LARGE SCALE ANALYSIS] MET-144; MET-496 AND HIS-588</scope>
  </reference>
  <comment type="function">
    <text evidence="3 11 17 18 19">Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525).</text>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="18 19">
      <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
      <dbReference type="Rhea" id="RHEA:17989"/>
      <dbReference type="Rhea" id="RHEA-COMP:9863"/>
      <dbReference type="Rhea" id="RHEA-COMP:11604"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:29999"/>
      <dbReference type="ChEBI" id="CHEBI:30616"/>
      <dbReference type="ChEBI" id="CHEBI:83421"/>
      <dbReference type="ChEBI" id="CHEBI:456216"/>
      <dbReference type="EC" id="2.7.11.13"/>
    </reaction>
    <physiologicalReaction direction="left-to-right" evidence="18 19">
      <dbReference type="Rhea" id="RHEA:17990"/>
    </physiologicalReaction>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="18">
      <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
      <dbReference type="Rhea" id="RHEA:46608"/>
      <dbReference type="Rhea" id="RHEA-COMP:11060"/>
      <dbReference type="Rhea" id="RHEA-COMP:11605"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:30013"/>
      <dbReference type="ChEBI" id="CHEBI:30616"/>
      <dbReference type="ChEBI" id="CHEBI:61977"/>
      <dbReference type="ChEBI" id="CHEBI:456216"/>
      <dbReference type="EC" id="2.7.11.13"/>
    </reaction>
    <physiologicalReaction direction="left-to-right" evidence="18">
      <dbReference type="Rhea" id="RHEA:46609"/>
    </physiologicalReaction>
  </comment>
  <comment type="cofactor">
    <cofactor evidence="5">
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
    </cofactor>
    <text evidence="2">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
  </comment>
  <comment type="activity regulation">
    <text evidence="13">Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615).</text>
  </comment>
  <comment type="subunit">
    <text evidence="1 14 16 18">Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and AR.</text>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-706216">
      <id>P05771</id>
    </interactant>
    <interactant intactId="EBI-744700">
      <id>Q8NEM2</id>
      <label>SHCBP1</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>3</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-706216">
      <id>P05771</id>
    </interactant>
    <interactant intactId="EBI-717399">
      <id>Q9BSI4</id>
      <label>TINF2</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>2</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-5774492">
      <id>P05771-1</id>
    </interactant>
    <interactant intactId="EBI-15599570">
      <id>O60341-1</id>
      <label>KDM1A</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>2</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-5774511">
      <id>P05771-2</id>
    </interactant>
    <interactant intactId="EBI-18899653">
      <id>Q6DHV7-2</id>
      <label>ADAL</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>3</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-5774511">
      <id>P05771-2</id>
    </interactant>
    <interactant intactId="EBI-1383687">
      <id>Q9UQM7</id>
      <label>CAMK2A</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>3</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-5774511">
      <id>P05771-2</id>
    </interactant>
    <interactant intactId="EBI-25830459">
      <id>Q6ZQX7-4</id>
      <label>LIAT1</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>3</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-5774511">
      <id>P05771-2</id>
    </interactant>
    <interactant intactId="EBI-2511516">
      <id>O60346</id>
      <label>PHLPP1</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>5</experiments>
  </comment>
  <comment type="interaction">
    <interactant intactId="EBI-5774511">
      <id>P05771-2</id>
    </interactant>
    <interactant intactId="EBI-2511496">
      <id>Q6ZVD8</id>
      <label>PHLPP2</label>
    </interactant>
    <organismsDiffer>false</organismsDiffer>
    <experiments>2</experiments>
  </comment>
  <comment type="subcellular location">
    <subcellularLocation>
      <location evidence="1">Cytoplasm</location>
    </subcellularLocation>
    <subcellularLocation>
      <location evidence="18">Nucleus</location>
    </subcellularLocation>
    <subcellularLocation>
      <location evidence="1">Membrane</location>
      <topology evidence="1">Peripheral membrane protein</topology>
    </subcellularLocation>
  </comment>
  <comment type="alternative products">
    <event type="alternative splicing"/>
    <isoform>
      <id>P05771-1</id>
      <name>Beta-I</name>
      <name>PRKCB1</name>
      <sequence type="displayed"/>
    </isoform>
    <isoform>
      <id>P05771-2</id>
      <name>Beta-II</name>
      <name>PRKCB2</name>
      <sequence type="described" ref="VSP_004738"/>
    </isoform>
  </comment>
  <comment type="PTM">
    <text evidence="1">Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).</text>
  </comment>
  <comment type="similarity">
    <text evidence="22">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
  </comment>
  <comment type="online information" name="NIEHS-SNPs">
    <link uri="http://egp.gs.washington.edu/data/prkcb1/"/>
  </comment>
  <dbReference type="EC" id="2.7.11.13" evidence="18 19"/>
  <dbReference type="EMBL" id="M13975">
    <property type="protein sequence ID" value="AAA60095.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="EMBL" id="X06318">
    <property type="protein sequence ID" value="CAA29634.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="EMBL" id="X07109">
    <property type="protein sequence ID" value="CAA30130.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="EMBL" id="FJ907246">
    <property type="protein sequence ID" value="ACS14045.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="AC130454">
    <property type="status" value="NOT_ANNOTATED_CDS"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="AC002299">
    <property type="protein sequence ID" value="AAB97933.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="AC002299">
    <property type="protein sequence ID" value="AAB97934.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="CH471145">
    <property type="protein sequence ID" value="EAW55797.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="CH471145">
    <property type="protein sequence ID" value="EAW55798.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="BC036472">
    <property type="protein sequence ID" value="AAH36472.1"/>
    <property type="molecule type" value="mRNA"/>
  </dbReference>
  <dbReference type="EMBL" id="X62532">
    <property type="protein sequence ID" value="CAA44393.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="S47311">
    <property type="protein sequence ID" value="AAD13852.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="D10022">
    <property type="protein sequence ID" value="BAA00912.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="AJ002799">
    <property type="protein sequence ID" value="CAA05725.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="AJ002800">
    <property type="protein sequence ID" value="CAA05725.1"/>
    <property type="status" value="JOINED"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="M18254">
    <property type="protein sequence ID" value="AAA60096.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="M18255">
    <property type="protein sequence ID" value="AAA60097.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="X05972">
    <property type="protein sequence ID" value="CAA29396.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="EMBL" id="X05971">
    <property type="protein sequence ID" value="CAA29395.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="CCDS" id="CCDS10618.1">
    <molecule id="P05771-1"/>
  </dbReference>
  <dbReference type="CCDS" id="CCDS10619.1">
    <molecule id="P05771-2"/>
  </dbReference>
  <dbReference type="PIR" id="B24664">
    <property type="entry name" value="KIHUC2"/>
  </dbReference>
  <dbReference type="PIR" id="S00159">
    <property type="entry name" value="KIHUC1"/>
  </dbReference>
  <dbReference type="RefSeq" id="NP_002729.2">
    <molecule id="P05771-2"/>
    <property type="nucleotide sequence ID" value="NM_002738.6"/>
  </dbReference>
  <dbReference type="RefSeq" id="NP_997700.1">
    <molecule id="P05771-1"/>
    <property type="nucleotide sequence ID" value="NM_212535.2"/>
  </dbReference>
  <dbReference type="PDB" id="2I0E">
    <property type="method" value="X-ray"/>
    <property type="resolution" value="2.60 A"/>
    <property type="chains" value="A/B=321-671"/>
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  <dbReference type="PDBsum" id="2I0E"/>
  <dbReference type="AlphaFoldDB" id="P05771"/>
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    <property type="interactions" value="196"/>
  </dbReference>
  <dbReference type="DIP" id="DIP-34187N"/>
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    <property type="interactions" value="144"/>
  </dbReference>
  <dbReference type="MINT" id="P05771"/>
  <dbReference type="STRING" id="9606.ENSP00000305355"/>
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  <dbReference type="ChEMBL" id="CHEMBL3045"/>
  <dbReference type="DrugBank" id="DB14001">
    <property type="generic name" value="alpha-Tocopherol succinate"/>
  </dbReference>
  <dbReference type="DrugBank" id="DB09096">
    <property type="generic name" value="Benzoyl peroxide"/>
  </dbReference>
  <dbReference type="DrugBank" id="DB08862">
    <property type="generic name" value="Cholecystokinin"/>
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    <property type="generic name" value="D-alpha-Tocopherol acetate"/>
  </dbReference>
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    <property type="generic name" value="Ellagic acid"/>
  </dbReference>
  <dbReference type="DrugBank" id="DB06486">
    <property type="generic name" value="Enzastaurin"/>
  </dbReference>
  <dbReference type="DrugBank" id="DB01738">
    <property type="generic name" value="Phosphorylcolamine"/>
  </dbReference>
  <dbReference type="DrugBank" id="DB00675">
    <property type="generic name" value="Tamoxifen"/>
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  <dbReference type="DrugBank" id="DB00163">
    <property type="generic name" value="Vitamin E"/>
  </dbReference>
  <dbReference type="DrugCentral" id="P05771"/>
  <dbReference type="GuidetoPHARMACOLOGY" id="1483"/>
  <dbReference type="TCDB" id="8.A.104.1.4">
    <property type="family name" value="the 5'-amp-activated protein kinase (ampk) family"/>
  </dbReference>
  <dbReference type="iPTMnet" id="P05771"/>
  <dbReference type="MetOSite" id="P05771"/>
  <dbReference type="PhosphoSitePlus" id="P05771"/>
  <dbReference type="BioMuta" id="PRKCB"/>
  <dbReference type="DMDM" id="20141488"/>
  <dbReference type="CPTAC" id="CPTAC-1338"/>
  <dbReference type="EPD" id="P05771"/>
  <dbReference type="jPOST" id="P05771"/>
  <dbReference type="MassIVE" id="P05771"/>
  <dbReference type="MaxQB" id="P05771"/>
  <dbReference type="PaxDb" id="P05771"/>
  <dbReference type="PeptideAtlas" id="P05771"/>
  <dbReference type="ProteomicsDB" id="51855">
    <molecule id="P05771-1"/>
  </dbReference>
  <dbReference type="ProteomicsDB" id="51856">
    <molecule id="P05771-2"/>
  </dbReference>
  <dbReference type="Antibodypedia" id="3547">
    <property type="antibodies" value="897 antibodies from 45 providers"/>
  </dbReference>
  <dbReference type="DNASU" id="5579"/>
  <dbReference type="Ensembl" id="ENST00000321728.12">
    <molecule id="P05771-1"/>
    <property type="protein sequence ID" value="ENSP00000318315.7"/>
    <property type="gene ID" value="ENSG00000166501.14"/>
  </dbReference>
  <dbReference type="Ensembl" id="ENST00000643927.1">
    <molecule id="P05771-2"/>
    <property type="protein sequence ID" value="ENSP00000496129.1"/>
    <property type="gene ID" value="ENSG00000166501.14"/>
  </dbReference>
  <dbReference type="GeneID" id="5579"/>
  <dbReference type="KEGG" id="hsa:5579"/>
  <dbReference type="MANE-Select" id="ENST00000643927.1">
    <molecule id="P05771-2"/>
    <property type="protein sequence ID" value="ENSP00000496129.1"/>
    <property type="RefSeq nucleotide sequence ID" value="NM_002738.7"/>
    <property type="RefSeq protein sequence ID" value="NP_002729.2"/>
  </dbReference>
  <dbReference type="UCSC" id="uc002dmd.4">
    <molecule id="P05771-1"/>
    <property type="organism name" value="human"/>
  </dbReference>
  <dbReference type="AGR" id="HGNC:9395"/>
  <dbReference type="CTD" id="5579"/>
  <dbReference type="DisGeNET" id="5579"/>
  <dbReference type="GeneCards" id="PRKCB"/>
  <dbReference type="HGNC" id="HGNC:9395">
    <property type="gene designation" value="PRKCB"/>
  </dbReference>
  <dbReference type="HPA" id="ENSG00000166501">
    <property type="expression patterns" value="Tissue enhanced (brain, lymphoid tissue)"/>
  </dbReference>
  <dbReference type="MIM" id="176970">
    <property type="type" value="gene"/>
  </dbReference>
  <dbReference type="neXtProt" id="NX_P05771"/>
  <dbReference type="OpenTargets" id="ENSG00000166501"/>
  <dbReference type="PharmGKB" id="PA33761"/>
  <dbReference type="VEuPathDB" id="HostDB:ENSG00000166501"/>
  <dbReference type="eggNOG" id="KOG0696">
    <property type="taxonomic scope" value="Eukaryota"/>
  </dbReference>
  <dbReference type="GeneTree" id="ENSGT00940000155217"/>
  <dbReference type="HOGENOM" id="CLU_000288_54_2_1"/>
  <dbReference type="InParanoid" id="P05771"/>
  <dbReference type="OMA" id="YIAPEXA"/>
  <dbReference type="OrthoDB" id="614710at2759"/>
  <dbReference type="PhylomeDB" id="P05771"/>
  <dbReference type="TreeFam" id="TF351133"/>
  <dbReference type="BRENDA" id="2.7.11.13">
    <property type="organism ID" value="2681"/>
  </dbReference>
  <dbReference type="PathwayCommons" id="P05771"/>
  <dbReference type="Reactome" id="R-HSA-114516">
    <property type="pathway name" value="Disinhibition of SNARE formation"/>
  </dbReference>
  <dbReference type="Reactome" id="R-HSA-1169091">
    <property type="pathway name" value="Activation of NF-kappaB in B cells"/>
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    </location>
    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>2</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="247"/>
    </location>
    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>2</label>
    </ligand>
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  <feature type="binding site" evidence="2">
    <location>
      <position position="248"/>
    </location>
    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>1</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="248"/>
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    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>2</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="248"/>
    </location>
    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>3</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="251"/>
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    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>3</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="252"/>
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    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>3</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="254"/>
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    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>1</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="2">
    <location>
      <position position="254"/>
    </location>
    <ligand>
      <name>Ca(2+)</name>
      <dbReference type="ChEBI" id="CHEBI:29108"/>
      <label>3</label>
    </ligand>
  </feature>
  <feature type="binding site" evidence="6">
    <location>
      <begin position="348"/>
      <end position="356"/>
    </location>
    <ligand>
      <name>ATP</name>
      <dbReference type="ChEBI" id="CHEBI:30616"/>
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  <feature type="binding site" evidence="6">
    <location>
      <position position="371"/>
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    <ligand>
      <name>ATP</name>
      <dbReference type="ChEBI" id="CHEBI:30616"/>
    </ligand>
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  <feature type="modified residue" description="N-acetylalanine" evidence="12">
    <location>
      <position position="2"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphoserine" evidence="25">
    <location>
      <position position="11"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphoserine; by autocatalysis" evidence="2 4">
    <location>
      <position position="16"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphothreonine" evidence="25">
    <location>
      <position position="17"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphoserine" evidence="25">
    <location>
      <position position="206"/>
    </location>
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  <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
    <location>
      <position position="250"/>
    </location>
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  <feature type="modified residue" description="Phosphoserine" evidence="25">
    <location>
      <position position="311"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphothreonine" evidence="25">
    <location>
      <position position="314"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="2 4">
    <location>
      <position position="324"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphothreonine; by PDPK1" evidence="23">
    <location>
      <position position="500"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphothreonine" evidence="24">
    <location>
      <position position="504"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="2">
    <location>
      <position position="635"/>
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  </feature>
  <feature type="modified residue" description="Phosphothreonine" evidence="14 25">
    <location>
      <position position="642"/>
    </location>
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  <feature type="modified residue" description="Phosphoserine; by autocatalysis" evidence="14">
    <location>
      <position position="661"/>
    </location>
  </feature>
  <feature type="modified residue" description="Phosphotyrosine; by SYK" evidence="3">
    <location>
      <position position="662"/>
    </location>
  </feature>
  <feature type="splice variant" id="VSP_004738" description="In isoform Beta-II." evidence="20 21">
    <original>RDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVINV</original>
    <variation>CGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS</variation>
    <location>
      <begin position="622"/>
      <end position="671"/>
    </location>
  </feature>
  <feature type="sequence variant" id="VAR_042304" description="In a colorectal adenocarcinoma sample; somatic mutation; dbSNP:rs764534677." evidence="15">
    <original>V</original>
    <variation>M</variation>
    <location>
      <position position="144"/>
    </location>
  </feature>
  <feature type="sequence variant" id="VAR_042305" description="In a glioblastoma multiforme sample; somatic mutation; dbSNP:rs1466858740." evidence="15">
    <original>V</original>
    <variation>M</variation>
    <location>
      <position position="496"/>
    </location>
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  <feature type="sequence variant" id="VAR_042306" description="In dbSNP:rs35631544." evidence="15">
    <original>P</original>
    <variation>H</variation>
    <location>
      <position position="588"/>
    </location>
  </feature>
  <feature type="sequence conflict" description="In Ref. 7; CAA44393." evidence="22" ref="7">
    <original>V</original>
    <variation>G</variation>
    <location>
      <position position="69"/>
    </location>
  </feature>
  <feature type="strand" evidence="27">
    <location>
      <begin position="342"/>
      <end position="351"/>
    </location>
  </feature>
  <feature type="strand" evidence="27">
    <location>
      <begin position="354"/>
      <end position="361"/>
    </location>
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  <feature type="strand" evidence="27">
    <location>
      <begin position="364"/>
      <end position="374"/>
    </location>
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    <location>
      <begin position="375"/>
      <end position="380"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="384"/>
      <end position="394"/>
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    <location>
      <begin position="406"/>
      <end position="411"/>
    </location>
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  <feature type="strand" evidence="27">
    <location>
      <begin position="413"/>
      <end position="421"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="428"/>
      <end position="435"/>
    </location>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="440"/>
      <end position="459"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="469"/>
      <end position="471"/>
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  <feature type="strand" evidence="27">
    <location>
      <begin position="472"/>
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  <feature type="strand" evidence="27">
    <location>
      <begin position="480"/>
      <end position="482"/>
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    <location>
      <begin position="505"/>
      <end position="507"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="510"/>
      <end position="513"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="521"/>
      <end position="536"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="546"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="566"/>
      <end position="575"/>
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  <feature type="helix" evidence="27">
    <location>
      <begin position="590"/>
      <end position="595"/>
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  <feature type="helix" evidence="27">
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      <begin position="598"/>
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      <begin position="605"/>
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      <begin position="629"/>
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      <begin position="654"/>
      <end position="657"/>
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    <location sequence="P05771-2">
      <position position="641"/>
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    <location sequence="P05771-2">
      <position position="660"/>
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  <evidence type="ECO:0000250" key="1"/>
  <evidence type="ECO:0000250" key="2">
    <source>
      <dbReference type="UniProtKB" id="P68403"/>
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  <evidence type="ECO:0000250" key="3">
    <source>
      <dbReference type="UniProtKB" id="P68404"/>
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  <evidence type="ECO:0000255" key="4"/>
  <evidence type="ECO:0000255" key="5">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00041"/>
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  <evidence type="ECO:0000255" key="6">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00159"/>
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  <evidence type="ECO:0000255" key="7">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00226"/>
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  <evidence type="ECO:0000255" key="8">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU00618"/>
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  </evidence>
  <evidence type="ECO:0000255" key="9">
    <source>
      <dbReference type="PROSITE-ProRule" id="PRU10027"/>
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  </evidence>
  <evidence type="ECO:0000256" key="10">
    <source>
      <dbReference type="SAM" id="MobiDB-lite"/>
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  <evidence type="ECO:0000269" key="11">
    <source>
      <dbReference type="PubMed" id="11598012"/>
    </source>
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  <evidence type="ECO:0000269" key="12">
    <source>
      <dbReference type="PubMed" id="12665801"/>
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  </evidence>
  <evidence type="ECO:0000269" key="13">
    <source>
      <dbReference type="PubMed" id="16103100"/>
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  <evidence type="ECO:0000269" key="14">
    <source>
      <dbReference type="PubMed" id="17115692"/>
    </source>
  </evidence>
  <evidence type="ECO:0000269" key="15">
    <source>
      <dbReference type="PubMed" id="17344846"/>
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  </evidence>
  <evidence type="ECO:0000269" key="16">
    <source>
      <dbReference type="PubMed" id="18162466"/>
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      <dbReference type="PubMed" id="19176525"/>
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  <evidence type="ECO:0000269" key="18">
    <source>
      <dbReference type="PubMed" id="20228790"/>
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  <evidence type="ECO:0000269" key="19">
    <source>
      <dbReference type="PubMed" id="25982116"/>
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  </evidence>
  <evidence type="ECO:0000303" key="20">
    <source>
      <dbReference type="PubMed" id="3666134"/>
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  </evidence>
  <evidence type="ECO:0000303" key="21">
    <source>
      <dbReference type="PubMed" id="3755548"/>
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  <evidence type="ECO:0000305" key="22"/>
  <evidence type="ECO:0000305" key="23">
    <source>
      <dbReference type="PubMed" id="17115692"/>
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  </evidence>
  <evidence type="ECO:0007744" key="24">
    <source>
      <dbReference type="PubMed" id="19369195"/>
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  </evidence>
  <evidence type="ECO:0007744" key="25">
    <source>
      <dbReference type="PubMed" id="23186163"/>
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  </evidence>
  <evidence type="ECO:0007744" key="26">
    <source>
      <dbReference type="PubMed" id="24275569"/>
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  </evidence>
  <evidence type="ECO:0007829" key="27">
    <source>
      <dbReference type="PDB" id="2I0E"/>
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  <sequence length="671" mass="76869" checksum="3937E7B667108C68" modified="2007-01-23" version="4">MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVINV</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>
None

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