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[[model]]
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name: akwaboah-2021-corrected
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- version: 20240324
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+ version: 20240325
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mmt_authors: Michael Clerx
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desc: """
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Model of the hiPSC AP by Akwaboah et al [1], with corrections.
@@ -513,7 +513,6 @@ K_IbCa = 1.6
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desc: Manual scaling factor
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IbCa = K_IbCa * G_bCa * (membrane.V - rev.ECa)
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in [A/F]
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- note: Scaling of ECa is not mentioned in the paper or supplement
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#
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# Background sodium current
@@ -602,7 +601,6 @@ jup = Pup / (1 + Kup / Ca_i)
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desc: Ca uptake by NSR
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tau_tr = 27.5 [ms]
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in [ms]
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- note: Paper (Table S8) agrees with Python value of 55 * 0.5
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jtr = (Ca_up - Ca_rel) / tau_tr
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desc: Transfer from NSR to JSR
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in [mM/ms]
@@ -621,18 +619,10 @@ dot(Ca_sub) = (
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- (ICaL + IpCa + IbCa - 2 * INaCa) * Cm / (2 * F * V_sub)
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- (jCa_diff + CM_tot * dot(cabuf.cms)))
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in [mM]
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- note: """
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- The C-version incorrectly multiplies the full equation by Cm.
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- The term involving the currents does require a multiplication by Cm
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- (which is not present in the Python version), but the other terms do
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- not need the extra Cm multiplication.
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- """
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dot(Ca_rel) = jtr - jrel - CQ_tot * dot(cabuf.cq)
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in [mM]
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- note: The C-version incorrectly multiplies this equation by Cm
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dot(Ca_up) = jup - jtr * (Vrel / V_up)
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in [mM]
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- note: The C-version incorrectly multiplies this equation by Cm
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#
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# Intracellular sodium
@@ -671,10 +661,8 @@ Na_o = 140 [mM]
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in [mM]
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K_o = 5.4 [mM]
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in [mM]
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- note: Increase to 10 or 12 to simulate hyperkalemia
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Ca_o = 2 [mM]
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in [mM]
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- note: Increase to 4 or 6 to simulate hypercalcemia
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#
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# Physical constants
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