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GlycoEnzOnto.gmt
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GlycoEnzOnto.gmt
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"6-sulfated sialyl lewis x biosynthetic pathway" "A metabolic process by which the 6-sulfated sialyl Lewis X antigen is created." CHST6 CHST2 CHST5
"I branching biosynthetic pathway" "A metabolic pathway whereby type I LacNAc structures receive an N-acetylglucosamine residue in a β1-6 linkage via GCNT2 or GCNT3." GCNT3 GCNT2
"N-N'-diacetyllactose diamine biosynthetic pathway" "A series of metabolic reactions whereby N-acetylgalactosamine is transferred onto N-acetylglucosamine." B3GALNT2 B4GALNT3 B4GALNT4 CHST9 CHST8
"POFUT1-type o-linked fucose biosynthetic pathway" "The series of metabolic reactions which add monosaccharides to o-linked fucose structure which was initiated by the POFUT1 glycoenzyme." LFNG RFNG POFUT1 B4GALT1 MFNG
"POFUT2-Type o-linked fucose biosynthetic pathway" "The series of metabolic reactions which add monosaccharides to o-linked fucose structure which was initiated by the POFUT2 glycoenzyme." POFUT2 B3GLCT
"POMGNT1-type o-mannose glycan biosynthetic pathway" "A series of metabolic reactions whereby mannose is attached to serine or threonine residues in proteins, followed by N-acetylglucosamine residues which results in the formation ofCore M1 or Core M2 O-mannose structures." MGAT5B POMGNT1 POMT2 POMT1
"POMGNT2-type o-mannose glycan biosynthetic pathway event" "A series of metabolic reactions whereby mannose is attached to serine or threonine residues on proteins and subsequently receives N-acetylglucosamine from the POMGNT2 enzyme, thus forming the Core M3 O-mannose structure." POMT1 POMT2 FKTN POMK RXYLT1 LARGE2 B4GAT1 LARGE1 B3GALNT2 FKRP POMGNT2
"POMT-type o-mannose glycan biosynthetic pathway" "A sequence of metabolic reactions whereby mannose is attached to serine or threonie residues on proteins through the action of POMT enzymes." POMT1 POMGNT2 POMK MGAT5B POMT2 FKTN POMGNT1 B3GALNT2 FKRP LARGE1 RXYLT1 B4GAT1 LARGE2
"Sda antigen biosynthetic pathway" "The process by which N-acetylgalactosamine is added to galactose in a b1-4 linkage by B4GALNT2." "B4GALNT2"
"TMTC-type o-mannosylation of proteins" "A process by which mannose is added onto serine or threonine residues on proteins through the action of TMTC1-4 proteins." TMTC1 TMTC3 TMTC2 TMTC4
"abo blood group biosynthetic pathway" "A metabolic pathway whereby fucosylation of blood group A (GalNAc(a1-3)Gal(b1-3)b-GlcNAc), B ( Gal(a1-3)Gal(b1-3)b-GlcNAc ), or O ( Gal(b1-3)b-GlcNAc ) is facilitated." FUT1 ABO FUT2
"c-linked mannose biosynthetic pathway" "A series of reactions whereby mannose is transferred to the 2 carbon of tryptophan in W-X-X-W motifs on cadherin and similar proteins." DPY19L2 DPY19L4 DPY19L1 DPY19L3
"chondroitin and dermatan sulfate core structure biosynthetic pathway" "A series of metabolic reactions which synthesize the core structures of both chondroitin and dermatan sulfate glycosaminoglycans. Involves the addition of n-acetylgalactosamine onto the core o-xylose glycosaminoglycan structure." CSGALNACT2 B3GALT6 B4GALT7 XYLT1 CSGALNACT1 B3GAT3 FAM20B XYLT2
"chondroitin and dermatan sulfate polymerization pathway" "A series of metabolic reactions whereby heparan sulfates receive N-acetylgalactosamine and glucuronic acid in an alternating fashion, which results in greater degree of polymerization." CSGALNACT2 CHSY1 DSE CHSY3 CHPF2 DSEL CSGALNACT1 CHPF
"chondroitin and dermatan sulfate sulfation pathway" "A a series of metabolic reactions where chondroitin and dermatan sulfates undergo sulfation on the N-acetylgalactosamine, glucuronic acid, or iduronic acid residues to variable degrees." CHST15 UST CHST7 CHST14 CHST12 CHST3 CHST13 CHST11
"chondroitin sulfate degradation pathway" "A series of catabolic reactions which degrade chondroitin sulfates." ARSB HEXA GUSB ARSK GALNS HEXB
"collagen degradation pathway" "A process by which galactose residues from collagen are removed." "PGGHG"
"collagen glycosylation pathway" "A series of metabolic processes whereby galactose is attached to serine or threonine residues on collagen." PLOD2 PLOD3 COLGALT2 PLOD1 COLGALT1
"core 1 type o-N-acetylgalactosamine type glycan biosynthetic pathway" "A series of metabolic reactions whereby galactose is added onto an O-linked N-acetylgalactosamine through the action of the galactosyltransferase C1GALT1 and its chaperone C1GALT1C1 to form the T antigen ( Gal(b1-3)GalNAc-Ser/Thr )." C1GALT1 C1GALT1C1 B3GNT3
"core 2 type o-N-acetylgalactosamine type glycan biosynthetic pathway" "A process by which N-acetylglucosamine is transferred to the T antigen to form Gal(b1-3)[GlcNAc(b1-6)]GalNAc(a1-Ser/Thr) through the action of GCNT1 or GCNT4." C1GALT1 C1GALT1C1 A4GNT GCNT1 GCNT3 GCNT4
"core 3 type o-N-acetylgalactosamine type glycan biosynthetic pathway" "A series of metabolic reactions whereby N-acetylglucosamine is added onto an O-linked N-acetylgalactosamine through the action of the B3GNT6 to form GlcNAc(b1-3)GalNAc(a1-Ser/Thr)." B3GALT5 B3GNT6
"core 4 type o-N-acetylgalactosamine type glycan biosynthetic pathway" "A process by which the Core 3 structure receives another N-acetylglucosamine structure through the action of GCNT3 to form GlcNAc(b1-3)[GlcNAc(b1-6)]GalNAc(a1-Ser/Thr)." "GCNT3"
"cytidine-5'-monophosphate n-acetylneuraminic acid synthetic pathway" "A sequence of metabolic events responsible for the synthesis of cytidine-5'-monophosophate n-acetylneuraminic acid." CMAS GNE RENBP
"cytoplasmic glycan degradation pathway" "A series of catabolic reactions which break down glycan structures in the cytoplasm." NEU2 ENGASE MAN2C1
"dermatan sulfate degradation pathway" "A series of catabolic reactions which degrade dermatan sulfates." GUSB IDUA ARSK IDS HEXB GALNS ARSB HEXA
"dolichol precursor biosynthetic pathway" "A metabolic process by which the N-linked glycan precursor structure is synthesized onto dolichol diphosphate in the endoplasmic reticulum." ALG1L2 ALG12 ALG13 RPN2 ALG14 DPM1 DPM2 ALG10 DDOST DAD1 ALG8 ALG10B ALG9 DPM3 ALG1L DPAGT1 ALG5 ALG6 ALG2 ALG1 RPN1 STT3A ALG11 STT3B ALG3
"extracellular glycan degradation pathway" "A series of catabolic reactions which break down glycan structures in the extracellular region." HPSE HYAL3 HYAL4 SULF1 SULF2 SPAM1 CEMIP2 HYAL2
"galactosylceramide biosynthetic pathway" "The initiation of galactosylceramide via the action of UGT8." "UGT8"
"ganglioside core structure biosynthetic pathway" "A series of metabolic reactions which synthesizes the Gal(b1-3)GalNAc(b1-4)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, B4GALNT1, and B3GALT4, as well as subsequent sialylation." UGCG B4GALNT1 B4GALT6 B3GALT4
"globo-series core structure biosynthetic pathway" "A series of metabolic reactions by which synthesizes the GalNAc(b1-3)Gal(a1-4)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, A4GALT, and B3GALNT1." UGCG B4GALT6 B3GALNT1 A4GALT
"glucose transport" "A process by which glucose is transported into the cytoplasm." SLC2A2 SLC2A1 SLC2A3 SLC2A4 SLC2A12 SLC2A8 SLC2A5 SLC2A10
"glucosylceramide biosynthetic pathway" "The series of metabolic reactions which add glucose onto ceramide and creates glucosylceramide core structures." B3GALNT1 B4GALT6 UGCG B3GALT4 A4GALT B4GALNT1 B3GALT5 B3GNT5
"glycan biosynthesis regulation" "A process by which a protein either promotes or hinders glycosylation through interaction with other proteins." GNPTG GNPTAB NAGPA HYOU1 SEL1L OS9 DNAJC10 HSPA5 LMAN2 DNAJB11 CANX IGF2R M6PR ERLEC1 CALR HSP90B1
"glycan biosynthetic pathway" "A sequence of anabolic and catabolic reactions responsible for the biosynthesis of glycan structures." MAN2A2 XXYLT1 B4GALT3 EXT2 MAN1A2 GALNT8 ALG10B GCNT2 DDOST SIAE B4GALT6 DAD1 B3GAT3 ALG1L B3GNT6 C1GALT1 CHST3 B3GLCT PIGU POMT2 EXTL2 PIGN CHST10 GLCE TMTC2 PIGH MGAT5 PIGF DSEL GALNT16 DPM3 ST6GAL1 B3GAT2 RFNG ST8SIA4 B3GALNT2 CASD1 GALNT12 GANAB PIGO LFNG ST8SIA6 PLOD2 GXYLT2 TMTC4 FUT4 XYLT2 COLGALT1 GALNT18 ST6GAL2 DPAGT1 ALG5 ST6GALNAC5 PIGG GALNT14 PIGX PIGY MGAT4A POGLUT1 ALG6 MGAT2 POFUT2 EDEM3 OGT MAN1B1 B4GALT5 TMTC1 POGLUT2 ALG1 ST3GAL2 OGA PIGV ALG11 GCNT4 ST3GAL5 GALNT17 POFUT1 FUT6 B3GNT3 B3GNT4 CSGALNACT2 PIGQ MANEA PIGL C1GALT1C1 ALG2 EDEM1 UGGT1 ST8SIA2 MOGS FUT3 POMT1 RXYLT1 ALG3 MGAT3 ST8SIA1 ST3GAL4 MAN1C1 PXYLP1 DPY19L2 MPPE1 GALNT7 ST3GAL3 B3GALT5 UGT8 TMTC3 B3GAT1 MGAT4B PIGK B3GALNT1 PIGM MGAT4C GCNT3 PIGC RPN1 FUT8 B4GALT7 B3GNT8 PIGZ ABO ST6GALNAC6 CSGALNACT1 PIGP PIGB CHSY1 FUT11 B4GAT1 DPM2 ST8SIA3 STT3A ALG12 STT3B ALG1L2 DPM1 ALG13 HAS2 FUT10 B4GALNT4 DPY19L4 ST6GALNAC3 FKTN COLGALT2 GALNT3 PIGT RPN2 CHPF2 FAM20B FUT7 GXYLT1 PLOD1 GALNT4 POMGNT1 B3GNT2 GALNT15 PIGW FKRP MFNG GALNT2 MAN2A1 FUT1 B4GALNT1 GALNT9 PIGS B3GALT2 EXTL1 MGAT1 FUT9 B3GALT6 GALNT19 GPAA1 B3GALT4 DPY19L1 GCNT1 CHPF PLOD3 GALNT10 GALNT5 ALG14 LARGE1 MGAT5B ALG10 UGGT2 GALNT11 CHSY3 POMGNT2 PGAP4 POMK FUT5 ST6GALNAC4 UGCG ST3GAL6 B3GNT5 ST6GALNAC1 EOGT ALG8 HAS3 B3GNT7 A3GALT2 PIGA ST8SIA5 DSE PRKCSH ALG9 EXT1 ST3GAL1 A4GALT GALNT1 B4GALT1 B4GALNT2 MAN1A1 ST6GALNAC2 CHST9 GALNT13 CHST8 B4GALNT3 EDEM2 B4GALT4 B3GALT1 B4GALT2 HAS1 XYLT1 DPY19L3 A4GNT EXTL3 FUT2 POGLUT3 LARGE2 GALNT6
"glycan capping structure biosynthetic pathway" "A sequence of reactions involving the transfer of monosaccharides to the non-reducing ends of glycans which, upon transfer, precludes any other monosaccharides from being attached." ST6GALNAC2 B4GALNT2 B4GALNT3 B3GALNT2 ST8SIA4 ST3GAL2 CHST10 ST8SIA2 ST6GAL1 FUT3 B3GAT2 CASD1 ST8SIA6 FUT4 ST6GAL2 ST3GAL3 ST6GALNAC5 B3GAT1 ST6GALNAC6 ABO ST8SIA3 ST3GAL5 FUT6 FUT10 ST8SIA1 ST3GAL4 FUT1 FUT9 FUT11 FUT5 ST6GALNAC4 ST6GALNAC3 ST6GALNAC1 A3GALT2 FUT7 ST8SIA5 CHST9 CHST8 FUT2 ST3GAL6 SIAE ST3GAL1
"glycan core structure biosynthetic pathway" "A set of metabolic reactions responsible for the addition of the first monosaccharide onto proteins and lipids, and the biosynthesis of distinct glycan structures which determines the glycan's class." PIGH B3GAT3 GALNT16 RFNG HAS1 PIGS PIGG GALNT1 B3GALT4 TMTC1 PGAP4 B3GALNT2 PIGV ALG5 PXYLP1 POMT1 MOGS PIGY C1GALT1C1 OGA LFNG DPAGT1 ALG9 B4GALT1 RPN2 B3GNT6 GCNT3 PIGL GXYLT1 GALNT12 POMT2 GALNT7 GALNT17 PIGF PLOD2 PIGO MGAT4B COLGALT2 XYLT1 PIGW A4GALT GALNT8 UGT8 STT3B TMTC3 ALG3 PIGU POFUT1 MAN1C1 B3GALT5 ALG1L2 MPPE1 ALG2 ALG10 FUT8 GALNT11 MAN2A2 MFNG MGAT5 GCNT4 MGAT4A DPY19L2 DAD1 B3GNT5 DPM3 FKTN MAN1A2 ALG13 B3GLCT B4GALNT1 PIGK UGGT2 POMK GALNT9 POGLUT2 B3GNT3 GALNT4 PLOD1 PIGX MGAT3 POFUT2 PRKCSH MGAT1 ALG6 UGGT1 DPM1 MAN1A1 ALG14 GPAA1 GALNT5 PIGA MGAT5B PIGC GALNT18 COLGALT1 GCNT1 PIGM PIGQ POMGNT1 FAM20B ALG1 B4GALT7 EDEM3 MANEA GALNT6 PIGZ POGLUT1 MGAT4C ALG12 EDEM1 DPM2 GALNT10 GALNT3 CSGALNACT2 GALNT19 B3GALNT1 ALG11 OGT GALNT13 HAS3 GALNT2 TMTC2 EXTL3 PIGT RXYLT1 EDEM2 PIGB GANAB PIGP UGCG FKRP A4GNT PLOD3 STT3A DDOST C1GALT1 EOGT XXYLT1 MAN1B1 DPY19L4 ALG10B DPY19L1 MAN2A1 POGLUT3 LARGE1 B4GAT1 RPN1 B3GALT6 B4GALT6 PIGN GALNT15 TMTC4 CSGALNACT1 DPY19L3 ALG1L XYLT2 HAS2 LARGE2 GALNT14 GXYLT2 ALG8 MGAT2 POMGNT2
"glycan degradation pathway" "A sequence of reactions whereby glycan structures are broken down through hydrolytic reactions cleaving glycosidic bonds or through the removal of modifying substituents." GLB1 GBA3 IDUA ARSK NEU1 HPSE2 HEXB GALC GANC HYAL2 MAN2C1 MANBA PGGHG SPAM1 MAN2B2 FUCA2 HPSE GAA ARSG CTBS GLA IDS HYAL4 NEU2 HEXA HGSNAT SULF2 NEU3 NAGA GBA2 HYAL3 GALNS SULF1 GNS NAGLU ARSB HYAL1 AGA GUSB CEMIP2 SGSH FUCA1 GBA ENGASE MAN2B1 NEU4
"glycan donor transport pathway" "A process by which substrates for glycosylation are transported from the cytosol into other compartments." SLC35D1 SLC35B3 SLC35C1 SLC35D2 SLC35A1 SLC35B4 SLC35A3 SLC35B2 SLC35A2
"glycan elongation and branching biosynthetic pathway" "A series of metabolic reactions whereby glycans receive a variable number of monosaccharides that increases their degree of polymerization and degree of branching." DSE C1GALT1 B3GALT1 CHSY3 B4GALNT4 CHPF2 B3GNT2 EXT2 B3GALT2 B4GALT1 EXT1 B4GALT5 CHST9 EXTL2 CSGALNACT1 B3GNT4 B4GALT3 EXTL1 GCNT2 B4GALNT3 B4GALT4 DSEL B4GALT2 EXTL3 CHPF CHSY1 B3GNT7 GCNT3 B3GNT8 GLCE CHST3 CHST8 CSGALNACT2 B3GALNT2 C1GALT1C1
"glycan molecular donor synthesis pathway" "A sequence of reactions which synthesize molecules that are covalently attached to glycan structures. This includes the synthesis nucleotide sugar substrates, and molecular substituents which modify monosaccharides, such as sulfate, phosphate, and ethanolamine." GALK1 PMM2 PGM1 GNE UAP1 NAGK GNPDA1 G6PC1 CMAS DPM1 UGP2 GALK2 GCK GMPPB PGM2 GFPT2 GALT GNPNAT1 GMPPA FCSK GALE HK2 PGM3 GMDS FPGT GFUS PAPSS1 RENBP MPI UGDH GNPDA2 UXS1 ALG5 CRPPA DPM2 DPM3 GFPT1 GPI HK3 AMDHD2 HK1 PAPSS2 PMM1 NANS
"glycan monosaccharide modification pathway" "A series of metabolic reactions whereby molecular substituents such as sulfate, phosphate and acetyl groups are covalently attached to proteins or monosaccharides present on glycans." HS3ST4 CHST14 GAL3ST3 CHST15 NDST4 CHST4 NDST3 CHST3 CHST7 HS3ST2 NDST2 CHST11 CHST6 TPST2 CHST2 GAL3ST2 GAL3ST1 HS3ST5 CHST12 HS6ST2 CHST5 HS3ST3A1 CHST1 HS3ST1 UST NDST1 CHST13 HS3ST3B1 HS6ST3 HS6ST1 HS2ST1 HS3ST6 GAL3ST4 TPST1
"glycan monosaccharide sulfation pathway" "A series of metabolic reactions whereby monosaccharides that are part of glycans receive a sulfate molecule" NDST3 HS3ST3A1 HS6ST3 NDST4 HS3ST1 CHST15 HS3ST4 HS3ST5 CHST14 GAL3ST1 HS3ST6 CHST7 HS3ST2 UST GAL3ST2 HS3ST3B1 GAL3ST4 CHST4 CHST2 NDST1 CHST12 CHST6 GAL3ST3 NDST2 CHST1 CHST3 HS6ST2 HS6ST1 CHST5 HS2ST1 CHST13 CHST11
"glycan substrate transport pathway" "A process by which molecules are transported from one cellular compartment to another." SLC2A4 SLC35B2 SLC2A8 SLC35A1 SLC2A12 SLC35C1 SLC35D1 SLC35B4 SLC2A3 SLC35D2 SLC35A3 SLC35A2 SLC2A10 SLC2A1 SLC35B3 SLC2A2 SLC2A5
"glycan-mediated lysosomal targeting" "A process by which GNPTAB and GNPTG transfer N-acetylglucosamine to unprocessed N-linked glycan mannose branches to mark proteins for transport to the lysosome." NAGPA GNPTG M6PR IGF2R GNPTAB
"glycolipid core structure biosynthetic pathway" "A series of reactions whereby glycans are initiated onto lipid molecules." B3GALNT1 PIGC PIGU PIGB DPM2 PIGW B4GALNT1 B4GALT6 GPAA1 PIGN B3GALT4 B3GNT5 PIGV A4GALT PIGM PIGL PIGZ PIGP MPPE1 B3GALT5 PIGT PIGK PIGS PIGH PIGF PGAP4 UGCG PIGO PIGY PIGG PIGX PIGQ PIGA UGT8
"glycosaminoglycan core structure biosynthetic pathway" "A series of metabolic reactions which initiate the synthesis of glycosaminoglycans on proteins through their core structure synthesis." HAS3 HAS1 XYLT2 EXTL3 XYLT1 B3GALT6 FAM20B CSGALNACT1 B3GAT3 B4GALT7 HAS2 PXYLP1 CSGALNACT2
"glycosaminoglycan degradation pathway" "A series of catabolic reactions which degrade glycosaminoglycans." HEXA SGSH HYAL2 ARSK ARSG IDS GUSB HEXB HYAL4 GALNS IDUA NEU3 GLB1 HYAL3 NEU4 HGSNAT HPSE HYAL1 NEU2 GNS NAGLU CEMIP2 ARSB SPAM1 NEU1
"glycosaminoglycan lysosomal degradation pathway" "A sequence of catabolic reactions whereby a glycosaminoglycan is degraded in the lysosome." HYAL1 NEU1 IDUA GLB1 IDS GUSB GALNS HEXA NEU4 ARSK GNS HEXB NEU3 ARSB
"glycosaminoglycan polymerization pathway" "A series of metabolic reactions which increase polysaccharide chain lengths of chondroitin, dermatan, and heparan sulfate through the action of glycosaminoglycan polymerases." EXTL3 EXTL1 EXT1 CHPF CHSY1 B3GNT7 B4GALT1 CSGALNACT1 CSGALNACT2 EXTL2 GLCE CHSY3 CHPF2 DSE B4GALT4 DSEL B4GALT3 B3GNT2 EXT2
"glycosaminoglycan sulfation pathway" "A series of metabolic reactions whereby sulfate molecules are covalently attached to monosaccharides which constitute glycosaminoglycans." HS3ST6 HS3ST1 CHST7 HS6ST3 NDST3 UST HS3ST5 CHST12 CHST6 CHST2 NDST4 NDST1 CHST1 NDST2 HS3ST4 CHST5 CHST14 HS3ST2 CHST3 HS2ST1 CHST11 CHST13 HS3ST3B1 HS6ST2 HS6ST1 HS3ST3A1 CHST15
"glycosphingolipid core structure biosynthetic pathway" "A series of metabolic reactions which initiate the synthesis of glycan onto sphingolipids and synthesize glycosphingolipid core structures." B4GALNT1 B4GALT6 UGT8 B3GNT5 B3GALT4 A4GALT UGCG B3GALT5 B3GALNT1
"glycosphingolipid degradation pathway" "A series of catabolic reactions which degrade glycosphingolipids." GLA NEU4 NAGA GBA3 FUCA1 GBA NEU2 FUCA2 HEXB NEU3 GBA2 NEU1 HEXA GLB1 GALC
"glycosphingolipid lysosomal degradation pathway" "A sequence of catabolic reactions whereby a glycosphingolipid is degraded in the lysosome." NEU1 NEU3 FUCA2 GLB1 GALC HEXB GLA NEU4 NAGA FUCA1 HEXA
"glycosylation-related pathway" "A sequence of metabolic or transitory events involved in the biosynthesis of glycans. This involves i. synthesis of nucleotide sugar substrates for glycosylation, ii. transport of nucleotide sugar substrates into the endoplasmic reticulum and Golgi, iii. biosynthesis of glycans, and iv. degradation of glycans." GAL3ST3 STT3A PLOD3 CANX HEXA SEL1L IGF2R GALNT3 CHST11 DPY19L2 B3GNT5 GAL3ST1 HYAL4 CSGALNACT2 EOGT RPN2 CHPF M6PR PAPSS1 ST8SIA3 GCNT3 PIGL GXYLT1 B4GALNT1 ST3GAL5 ABO DPY19L4 UGGT2 POMK UXS1 DPY19L1 FUT5 GPI LARGE1 GALNT17 B4GAT1 ALG11 RPN1 OGT GALNT4 B3GNT4 B3GALT6 ST3GAL4 MGAT4B FUT1 DNAJB11 PGM3 CRPPA UGT8 SLC35B2 PRKCSH HYAL1 SLC2A3 TMTC3 OS9 ALG3 B3GNT2 SLC35C1 CHST12 UGP2 ST6GALNAC4 SULF1 A3GALT2 UGT2B4 MAN1C1 B3GALT5 ST6GALNAC3 GBA2 MAN1A1 FUT10 MAN2B2 CEMIP2 ALG14 EXTL1 MPPE1 CHST8 PIGA ALG10 ST6GALNAC1 HS3ST3B1 RXYLT1 HYAL2 PIGB HS3ST6 NEU1 GALK1 ARSG POMGNT1 FAM20B FKRP SULF2 SLC2A10 MFNG FUT11 GALNT1 PGM1 GALNT6 B3GALT2 SLC35A3 UGT1A9 FKTN UGT2A1 UGT1A5 GNE ALG13 ERLEC1 B4GALT2 PIGK GALNT10 MAN2A1 UGT2B28 ST8SIA5 FUT7 ST3GAL6 GALNT9 FPGT GUSB SLC35A1 EXT1 CHST9 FUT2 GALNT15 PLOD1 B4GALNT4 CSGALNACT1 G6PC1 NDST1 HAS2 HS6ST1 MGAT1 DNAJC10 SLC2A5 UGT2B10 ALG8 ARSB DPM1 NAGA GALNT13 GNPTAB DSE POMGNT2 UGT3A1 SLC2A4 GPAA1 CHST1 SLC35B3 GALNT5 CHST15 GALC HAS3 CHST2 MGAT5B AGA HGSNAT TMTC2 CHSY3 UGT1A1 B3GALT1 B4GALT3 GAL3ST2 GCNT1 HAS1 GFPT2 ST3GAL1 PIGS IDUA B3GALT4 PLOD2 UGT2A3 HS3ST1 SIAE CHST5 AMDHD2 ENGASE PGAP4 GALT PGGHG SLC35D2 DDOST GMPPB ST6GALNAC2 B4GALNT2 C1GALT1 HS6ST3 UGT1A3 SLC2A8 GAL3ST4 CMAS PIGU SLC2A2 HSP90B1 GALNT19 NEU2 XXYLT1 HS6ST2 NDST4 GALNS ALG10B GNPTG B4GALT4 POGLUT3 HK2 TPST2 HS3ST2 MAN2A2 EXT2 B4GALT6 PIGN CTBS UGT3A2 TMTC4 DPY19L3 ALG1L CHST6 XYLT2 HS3ST4 HK1 NEU4 NAGLU ALG9 MGAT5 GNPDA2 GCNT4 B4GALNT3 HPSE EXTL2 GLA CHST3 HS3ST5 MGAT4A DSEL NANS DAD1 ST8SIA4 DPM3 B4GALT5 GXYLT2 B3GNT7 SLC35D1 EXTL3 GCNT2 B4GALT1 MGAT2 GANC GNPNAT1 B3GNT6 MAN2B1 CALR B3GLCT GALNT12 CHST14 POMT2 PGM2 CMAHP HK3 EDEM2 B3GAT2 PIGH PIGF POGLUT2 GANAB PIGO NAGPA FCSK UGT2B11 XYLT1 PMM2 A4GALT A4GNT GALNT8 MGAT3 HYOU1 GCK UGT1A7 GMPPA PIGG ARSK UGT1A10 FUT4 ALG6 ST6GAL1 UGGT1 CHST13 TMTC1 GBGT1 GLCE B3GALNT2 MAN1B1 NEU3 NAGK FUT3 GLB1 GALE ALG5 POMT1 PIGQ GFPT1 HSPA5 ST6GALNAC5 B3GNT8 HEXB UGDH C1GALT1C1 EDEM3 CHST10 FUCA1 MANEA POGLUT1 SLC2A12 CHSY1 LARGE2 GALNT14 CASD1 MAN1A2 OGA LFNG LMAN2 SGSH DPAGT1 ST3GAL2 CHST7 SLC35A2 ST8SIA6 HPSE2 ST3GAL3 HS3ST3A1 PMM1 PAPSS2 GAA NDST2 B3GAT3 GBA B3GNT3 GALNT16 UGT2B15 RFNG MANBA UGT1A6 PIGX MPI HS2ST1 GFUS B3GAT1 GALNT7 POFUT2 B3GALNT1 RENBP TPST1 GALK2 ST8SIA2 FUCA2 MAN2C1 GNPDA1 UST COLGALT2 IDS CHST4 UGT2B17 PIGW CHPF2 FUT6 GNS HYAL3 STT3B SLC2A1 UAP1 GALNT2 SPAM1 ST8SIA1 UGT2B7 PIGV UGT2A2 POFUT1 PIGC GALNT18 PXYLP1 SLC35B4 ALG1L2 COLGALT1 MOGS PIGM PIGY ALG2 ALG1 PIGT FUT8 B4GALT7 GBA3 GMDS UGT1A8 PIGP FUT9 PIGZ UGT1A4 NDST3 MGAT4C ST6GAL2 GALNT11 UGCG ALG12 EDEM1 DPM2 ST6GALNAC6
"glycosylphosphatidylinositol anchor biosynthetic pathway" "The metabolic process by which the Glycosylphosphatidylinositol (GPI) anchor is synthesized sequentially by PIG enzymes in the endoplasmic reticulum." GPAA1 PIGS PIGC PIGV PIGQ PIGX PIGL DPM2 PIGU PIGH MPPE1 PIGK PIGB PIGG PIGA PIGM PIGY PIGZ B3GALT4 PIGW PIGT PIGP PIGO PIGF PGAP4 PIGN
"guanosine-5'-diphosphate fucose synthetic pathway" "A sequence of metabolic events responsible for the synthesis of guanosine-5'-diphosphate fucose." FCSK FPGT GMDS GFUS
"guanosine-5'-diphosphate mannose synthetic pathway" "A sequence of metabolic events responsible for the synthesis of guanosine-5'-diphosphate mannose." GCK HK1 GMPPA G6PC1 HK2 GMPPB PMM1 MPI PMM2 HK3
"guanosine-5'-diphosphate mannose transport" "A process by which GDP-mannose is transported from the cytoplasm to the endoplasmic reticulum." "SLC35D2"
"heparan sulfate amine sulfation pathway" "A series of metabolic reactions whereby the amine structure on glucosamine undergo sulfation to varying degrees." NDST2 NDST1 NDST3 NDST4
"heparan sulfate core structure biosynthetic pathway" "A series of metabolic reactions which synthesize the core structures of heparan sulfate glycosaminoglycans. Involves the addition of n-acetylglucosamine onto the core o-xylose glycosaminoglycan structure." FAM20B B3GALT6 EXTL3 XYLT2 B3GAT3 B4GALT7 XYLT1
"heparan sulfate degradation pathway" "A series of catabolic reactions which degrade heparan sulfates." HPSE HGSNAT GNS NAGLU SGSH IDS GUSB ARSK ARSG IDUA
"heparan sulfate lysosome degradation pathway" "A sequence of catabolic reactions whereby heparan sulfate is degraded in the lysosome." IDUA IDS HPSE ARSG SGSH ARSK HGSNAT GNS GUSB NAGLU
"heparan sulfate polymerization pathway" "A series of metabolic reactions whereby heparan sulfates receive N-acetylglucosamine and glucuronic acid in an alternating fashion, which results in greater heparan sulfate degree of polymerization." EXTL3 EXT2 EXTL2 EXT1 EXTL1 GLCE
"heparan sulfate sulfation pathway" "A series of metabolic reactions where heparan sulfates undergo sulfation on the N-acetylglucosamine, glucuronic acid, or iduronic acid residues to variable degrees." HS6ST2 HS3ST4 NDST1 HS3ST3B1 HS3ST3A1 HS6ST1 HS2ST1 HS3ST5 HS6ST3 NDST3 NDST4 HS3ST1 HS3ST2 HS3ST6 NDST2
"human natural killer 1 epitope biosynthetic pathway" "A series of metabolic reactions which synthesis the human natural killer 1 epitope." CHST10 B3GAT1 B3GAT2
"hyaluronan biosynthetic pathway" "A series of metabolic reactions which facilitate hyaluronan polysaccharide synthesis." HAS2 HAS1 HAS3
"hyaluronic acid degradation pathway" "A series of catabolic reactions which degrade hyaluronic acids." HYAL1 HYAL4 HYAL3 SPAM1 CEMIP2 HYAL2
"hyaluronic acid extracellular degradation pathway" "A process by which hyaluronic acid is degraded in the extracellular matrix." HYAL4 HYAL3 CEMIP2 HYAL2 SPAM1
"keratan sulfate degradation pathway" "A series of catabolic reactions which degrade keratan sulfates." GNS HEXB NEU3 GLB1 GALNS NEU4 HEXA NEU2 NEU1
"keratan sulfate lysosomal degradation pathway" "A sequence of catabolic reactions whereby keratan sulfate is degraded in the lysosome." GALNS GNS NEU3 HEXA GLB1 HEXB NEU1 NEU4
"keratan sulfate polymerization pathway" "A series of metabolic reactions whereby keratan sulfates undergo repeated Type II LacNAc extension." B3GNT7 B4GALT4 B4GALT1 B4GALT3 B3GNT2
"keratan sulfate sulfation pathway" "A series of metabolic reactions where keratan sulfate receives sulfations on N-acetylglucosamine and galactose residues in LacNAc chains on either N-linked or O-linked glycans." CHST1 CHST2 CHST6 CHST3 CHST5
"lacto-series core structure biosynthetic pathway" "A series of metabolic reactions which synthesizes the Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, B3GNT5, and B3GALNT1." UGCG B3GNT5 B3GALT5 B4GALT6
"lysosomal glycan degradation pathway" "A series of catabolic reactions which degrade glycans in the lysosomal lumen." MAN2B1 SGSH MAN2B2 HYAL1 HPSE GLB1 NEU1 FUCA1 HEXA NEU4 GUSB GALNS GLA MANBA IDUA CTBS GALC HGSNAT ARSB IDS GNS AGA NAGLU ARSK NAGA HEXB NEU3 ARSG FUCA2
"monosaccharide modification transport pathway" "A process by which substrates required for the modification of monosaccharides on glycan structures are transported into the endoplasmic reticulum or Golgi." SLC35B3 SLC35B2
"monosaccharide transport" "A process by which nutrients are transported into the cytoplasm from outside the cell." SLC2A5 SLC2A4 SLC2A8 SLC2A2 SLC2A3 SLC2A10 SLC2A1 SLC2A12
"monosaccharide-modifying substituent synthetic pathway" "A sequence of reactions responsible for synthesizing substituents that modify monosaccharides, such as sulfate, phosphate, and ethanolamine." PAPSS2 PAPSS1
"n-acetylneuraminic acid acetylation and deacetylation pathway" "The addition or removal of acetyl groups onto Neu5Ac to form or degrade Neu5,9Ac." CASD1 SIAE
"n-glycan trimming pathway" "A series of metabolic reactions whereby the dolichol precursor structure is trimmed successively via glucosidases and mannosidases." MAN2A2 UGGT2 MAN1A2 GANAB UGGT1 MOGS MANEA EDEM2 MAN1B1 PRKCSH EDEM3 MAN1A1 MAN2A1 EDEM1 MAN1C1
"n-linked glycan branching biosynthetic pathway" "A series of metabolic reactions whereby N-linked glycans receive N-acetylglucosamine residues through the action of MGAT enzymes." MGAT4A MGAT3 MGAT2 MGAT5 MGAT5B MGAT4B FUT8 MGAT1 MGAT4C
"n-linked glycan core structure biosynthetic pathway" "N-linked glycosylation occurs on protein asparagine residues within an N-X-S/T sequon. N-linked glycans are characterized by having GlcNAc residues attached onto asparagine at the root of the glycan. N-linked glycans are synthesized in 3 stages: the dolichol pathway, processing, and optionally, branching." STT3A STT3B ALG13 ALG12 RPN2 FUT8 DPM2 ALG1L2 DPM1 MAN2A1 ALG10 MGAT1 MGAT5B ALG14 UGGT2 PRKCSH ALG8 MAN1A1 EDEM2 ALG9 MAN2A2 DDOST DAD1 ALG10B MAN1A2 DPM3 ALG1L DPAGT1 ALG5 MGAT5 GANAB MGAT2 EDEM3 ALG1 ALG11 MGAT4A MAN1B1 UGGT1 MOGS ALG6 ALG3 MGAT4B EDEM1 MANEA ALG2 MGAT4C RPN1 MAN1C1 MGAT3
"n-linked glycan degradation pathway" "A series of catabolic reactions which degrade N-linked glycans." HEXA NEU2 MAN2B2 NEU3 NEU4 MAN2B1 FUCA1 ENGASE GLB1 NEU1 FUCA2 MAN2C1 AGA HEXB MANBA CTBS
"n-linked glycan lysosomal degradation pathway" "A sequence of catabolic reactions whereby an n-linked glycan is degraded in the cytoplasm." HEXB FUCA2 FUCA1 NEU4 MAN2B1 MAN2B2 NEU1 HEXA NEU3 MANBA CTBS AGA GLB1
"neolacto-series core structure biosynthetic pathway" "A series of metabolic reactions which synthesizes the Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, B3GNT5, and a myriad of B4GALTs." UGCG B4GALT6 B3GNT5
"nucleotide sugar biosynthetic pathway" "A sequence of metabolic reactions whereby monosaccharides are covalently attached to various nucleotides in the cytoplasm to form nucleotide sugar substrates for glycosylation." GMPPB FPGT GCK PGM2 MPI GMPPA CRPPA GALE GPI UGDH PMM1 NANS DPM2 GFUS PMM2 GNE UAP1 HK1 AMDHD2 NAGK GNPDA1 DPM1 UXS1 HK2 GFPT1 GALK1 PGM3 HK3 GNPDA2 ALG5 DPM3 GFPT2 PGM1 G6PC1 GALK2 CMAS RENBP UGP2 GALT GNPNAT1 GMDS FCSK
"nucleotide sugar transport" "A process by which nucleotide sugars synthesized in the cytoplasm are transported into the endoplasmic reticulum or Golgi to serve as substrates for glycosylation." SLC35B4 SLC35C1 SLC35A2 SLC35D1 SLC35A1 SLC35D2 SLC35A3
"o-fucosylation type glycan biosynthetic pathway" "A series of metabolic reactions which attach fucose to serine or threonine residues in EGF-like repeats ( CXXXX(S/T)C ), and subsequently extend them." POFUT2 B3GLCT RFNG LFNG B4GALT1 POFUT1 MFNG
"o-linked glucose biosynthetic process" "A metabolic pathway where glucose is attached onto serine or threonine residues on proteins." POGLUT1 POGLUT3 XXYLT1 GXYLT2 POGLUT2 GXYLT1
"o-linked glycan biosynthetic pathway" "A series of metabolic reactions which transfer the first monosaccharides onto oxygen atoms of amino acids and the subsequent initiation of o-glycan classes." GALNT1 C1GALT1C1 XXYLT1 POGLUT1 GALNT7 GALNT5 GALNT16 GALNT13 GCNT4 POFUT2 GALNT6 POMT2 OGT PLOD2 TMTC4 GALNT10 GALNT19 LFNG POGLUT3 GALNT3 GALNT11 GALNT15 RFNG GALNT2 GALNT18 POGLUT2 C1GALT1 EOGT B3GALNT2 FKRP PLOD3 A4GNT GCNT3 GXYLT1 POMGNT2 GALNT9 GALNT4 MFNG B4GALT1 POFUT1 GXYLT2 GALNT17 B3GNT3 GALNT8 OGA TMTC3 POMT1 GCNT1 B3GNT6 POMGNT1 GALNT12 LARGE1 FKTN B3GLCT COLGALT2 PLOD1 COLGALT1 GALNT14 TMTC1 RXYLT1 POMK B4GAT1 MGAT5B B3GALT5 TMTC2 LARGE2
"o-linked glycan degradation pathway" "A series of catabolic reactions which degrade O-linked glycans." NEU2 HEXA NEU3 NEU4 NAGA NEU1 FUCA1 GLB1 FUCA2 HEXB
"o-linked glycan lysosomal degradation pathway" "A sequence of catabolic reactions whereby an o-linked glycan is degraded in the lysosome." NEU3 NEU4 NEU1 FUCA1 HEXA GLB1 HEXB NAGA FUCA2
"o-linked glycan sulfation biosynthetic pathway" "A series of metabolic reactions whereby sulfate molecules are covalently attached to monosaccharides which constitute some o-linked glycan." CHST4 GAL3ST4 GAL3ST2 CHST2 CHST1 CHST6 CHST5 GAL3ST3
"o-linked xylose glycosaminoglycan core structure biosynthetic pathway" "A series of metabolic reactions whereby chondroitin, dermatan, and heparan sulfates are initiated." XYLT2 XYLT1 B3GAT3 B4GALT7 PXYLP1 B3GALT6 FAM20B
"o-n-acetylgalactosamine type glycan biosynthetic pathway" "A series of metabolic reactions which attach N-acetylgalactosamine onto serine or threonine residues of amino acids and create the core o-linked glycan structures." GALNT5 B3GALT5 GALNT3 GALNT15 GALNT9 GALNT17 C1GALT1C1 GALNT2 A4GNT GALNT14 B3GNT3 GALNT8 C1GALT1 GALNT1 GALNT19 GALNT12 GALNT7 GALNT18 GALNT13 GALNT6 GCNT1 GALNT11 GALNT10 GCNT3 GALNT16 B3GNT6 GALNT4 GCNT4
"o-n-acetylglucosamine EGF repeat" "Extracellular n-acetylglucosamine modification of EGF-like repeats on ceullar surface proteins." "EOGT"
"o-n-acetylglucosamine protein glycosylation pathway" "A metabolic process by which N-acetylglucosamine is attached to serine or threonine residues on nuclear cytoplasmic proteins." OGA OGT
"phosphoadenosine phosphosulfate synthetic pathway" "A process by which phosphoadenosine phosphosulfate (PAPS) is synthesized." PAPSS1 PAPSS2
"phosphoadenosine phosphosulfate transport" "The process by which PAPS is transported into the Golgi to be a substrate for glycan sulfation." SLC35B3 SLC35B2
"protein sulfation process" "A process whereby sulfate groups are transfered onto proteins as a post-translational modification." TPST1 TPST2
"putative or unknown glycosylation pathway" "A class describing glycoenzymes with unknown involvement in glycosylation. They are still under investigation or have been postulated to participate in pathways but lack experimental evidence." CMAHP GBGT1
"terminal fucosylation biosynthetic pathway" "A series of metabolic reactions responsible for the addition of fucose onto the termini of glycan structures, thus precluding further glycan extension and modificaiton." FUT7 FUT10 FUT5 FUT1 FUT11 FUT2 FUT4 FUT6 FUT9 FUT3
"terminal galactose sulfation pathway" "The process by which galactose residues present in galactosylceramides are sulfated." GAL3ST2 GAL3ST1 GAL3ST3 GAL3ST4
"terminal sialylation biosynthetic pathway" "The process of the addition of sialic acid onto the non-reducing ends of glycan structures." ST6GAL1 ST6GALNAC3 ST6GALNAC5 ST3GAL3 ST3GAL2 ST8SIA6 ST6GALNAC2 ST8SIA2 ST8SIA1 ST8SIA3 ST3GAL5 ST3GAL4 ST6GALNAC4 ST6GALNAC1 ST8SIA4 ST3GAL6 ST8SIA5 ST6GAL2 ST6GALNAC6 ST3GAL1
"terminal sialylation of gangliosides biosynthetic pathway" "The process of the addition of sialic acid onto the non-reducing ends of gangliosides." ST6GALNAC5 ST8SIA3 ST3GAL5 ST8SIA1 ST6GALNAC4 ST8SIA5 ST3GAL2 ST6GALNAC6 ST6GALNAC3
"terminal sialylation of n-linked glycans biosynthetic pathway" "The process of the addition of sialic acid onto the non-reducing ends of n-linked glycan structures." ST8SIA4 ST3GAL6 ST3GAL4 ST3GAL3 ST8SIA3 ST6GAL2 ST6GAL1 ST8SIA2
"terminal sialylation of o-linked fucose glycans biosynthetic pathway" "The process of the addition of sialic acid onto the non-reducing ends of o-linked fucose-type glycans." ST6GAL2 ST6GAL1
"terminal sialylation of o-linked glycans biosynthetic pathway" "The process of the addition of sialic acid onto the non-reducing ends of o-linked glycan structures." ST6GAL1 ST3GAL3 ST3GAL6 ST8SIA2 ST8SIA4 ST6GALNAC4 ST6GALNAC3 ST6GALNAC1 ST3GAL4 ST8SIA6 ST6GAL2 ST3GAL1 ST6GALNAC2
"type i lactosamine biosynthetic pathway" "A metabolic pathway whereby the disaccharide [Gal(β1-3)GlcNAc] is synthesized on glycans." B3GALT1 B3GALT2
"type i lactosamine extension of n-linked glycan biosynthetic pathway" "The biosynthesis of type i lactosamine chains on n-linked glycans." B3GALT1 B3GALT2
"type i lactosamine extension of o-n-acetylgalactossamine glycan biosynthetic pathway" "The biosynthesis of type i lactosamine chains on o-GalNAc glycans." B3GALT2 B3GALT1
"type ii lactosamine biosynthetic pathway" "A process by which the disaccharide [Gal(β1-4)GlcNAc] is synthesized on glycans." B4GALT5 B4GALT3 B3GNT4 B3GNT2 B4GALT2 B3GNT7 B3GNT8 CHST3 B4GALT4 B4GALT1
"type ii lactosamine extension of o-n-acetylgalactosamine glycan biosynthetic pathway" "The biosynthesis of type ii lactosamine chains on O-GalNAc glycans." B4GALT1 B3GNT7 B3GNT8 B3GNT2 B4GALT2 B3GNT4 B4GALT5 B4GALT3 B4GALT4
"type iii lactosamine biosynthetic pathway" "A metabolic pathway whereby the disaccharide [Gal(β1-3)GalNAc] is synthesized on glycans." C1GALT1C1 C1GALT1
"uridine-5'-diphosphate galactose synthetic pathway" "A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate galactose." GALT GALK1 GALE
"uridine-5'-diphosphate glucose synthetic pathway" "A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate glucose." HK3 PGM1 HK2 GCK UGP2 GPI GALE G6PC1 HK1 PGM2
"uridine-5'-diphosphate glucuronic acid synthetic pathway" "A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate glucuronic acid." "UGDH"
"uridine-5'-diphosphate glucuronic acid transport" "A process by which UDP-glucuronic acid is transported from the cytoplasm to the Golgi." "SLC35D1"
"uridine-5'-diphosphate n-acetylgalactosamine synthetic pathway" "A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate n-acetylgalactosamine." GALK2 GALE UAP1
"uridine-5'-diphosphate n-acetylgalactosamine transport" "A process by which UDP-N-acetylgalactosamine is transported from the cytoplasm to the Golgi." "SLC35D1"
"uridine-5'-diphosphate n-acetylglucosamine synthetic pathway" "A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate n-acetylglucosamine." GALE AMDHD2 PGM3 UAP1 GNPNAT1 NAGK GNPDA2 GFPT2 GFPT1 GNPDA1
"uridine-5'-diphosphate xylose synthetic pathway" "A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate xylose." "UXS1"
"xenobiotic glucuronidation pathway" "A process by which glucuronic acid is covalently linked onto xenobiotics for their clearance by the excretory system." UGT1A1 UGT2A2 UGT2B10 UGT2B15 UGT2B4 UGT2B11 UGT2B7 UGT1A3 UGT2B17 UGT1A9 UGT3A1 UGT1A10 UGT1A5 UGT2A1 UGT1A4 UGT2A3 UGT1A7 UGT1A6 UGT1A8 UGT2B28 UGT3A2