diff --git a/src/App.vue b/src/App.vue
index 10769c577e9..5966516e831 100644
--- a/src/App.vue
+++ b/src/App.vue
@@ -20,7 +20,7 @@
 -->
 
 <template>
-	<NcContent v-shortkey.once="['ctrl', 'f']"
+	<NcContent v-shortkey.once="disableKeyboardShortcuts ? null : ['ctrl', 'f']"
 		:class="{ 'icon-loading': loading, 'in-call': isInCall }"
 		app-name="talk"
 		@shortkey.native="handleAppSearch">
@@ -196,6 +196,10 @@ export default {
 		isOneToOne() {
 			return this.currentConversation?.type === CONVERSATION.TYPE.ONE_TO_ONE
 		},
+
+		disableKeyboardShortcuts() {
+			return OCP.Accessibility.disableKeyboardShortcuts()
+		},
 	},
 
 	watch: {
diff --git a/src/components/CallView/shared/LocalMediaControls.vue b/src/components/CallView/shared/LocalMediaControls.vue
index 7c7dec35aee..437de45e6f0 100644
--- a/src/components/CallView/shared/LocalMediaControls.vue
+++ b/src/components/CallView/shared/LocalMediaControls.vue
@@ -18,7 +18,7 @@
   -
   -->
 <template>
-	<div v-shortkey.push="['space']"
+	<div v-shortkey.push="disableKeyboardShortcuts ? null : ['space']"
 		@shortkey="handleShortkey">
 		<div class="buttons-bar">
 			<div class="network-connection-state">
@@ -59,7 +59,7 @@
 				</NcPopover>
 			</div>
 			<div id="muteWrapper">
-				<NcButton v-shortkey.once="['m']"
+				<NcButton v-shortkey.once="disableKeyboardShortcuts ? null : ['m']"
 					v-tooltip="audioButtonTooltip"
 					type="tertiary-no-background"
 					:aria-label="audioButtonAriaLabel"
@@ -80,7 +80,7 @@
 					class="volume-indicator"
 					:class="{'microphone-off': !showMicrophoneOn}" />
 			</div>
-			<NcButton v-shortkey.once="['v']"
+			<NcButton v-shortkey.once="disableKeyboardShortcuts ? null : ['v']"
 				v-tooltip="videoButtonTooltip"
 				type="tertiary-no-background"
 				:aria-label="videoButtonAriaLabel"
@@ -156,13 +156,13 @@
 					{{ t('spreed', 'Stop screensharing') }}
 				</NcActionButton>
 			</NcActions>
-			<NcButton v-shortkey.once="['r']"
-				v-tooltip="t('spreed', 'Lower hand (R)')"
+			<NcButton v-shortkey.once="disableKeyboardShortcuts ? null : ['r']"
+				v-tooltip="disableKeyboardShortcuts ? t('spreed', 'Lower hand') : t('spreed', 'Lower hand (R)')"
 				type="tertiary-no-background"
 				class="lower-hand"
 				:class="model.attributes.raisedHand.state ? '' : 'hidden-visually'"
 				:tabindex="model.attributes.raisedHand.state ? 0 : -1"
-				:aria-label="t('spreed', 'Lower hand (R)')"
+				:aria-label="disableKeyboardShortcuts ? t('spreed', 'Lower hand') : t('spreed', 'Lower hand (R)')"
 				@shortkey="toggleHandRaised"
 				@click.stop="toggleHandRaised">
 				<template #icon>
@@ -339,8 +339,14 @@ export default {
 	computed: {
 		raiseHandButtonLabel() {
 			if (!this.model.attributes.raisedHand.state) {
+				if (this.disableKeyboardShortcuts) {
+					return t('spreed', 'Raise hand')
+				}
 				return t('spreed', 'Raise hand (R)')
 			}
+			if (this.disableKeyboardShortcuts) {
+				return t('spreed', 'Lower hand')
+			}
 			return t('spreed', 'Lower hand (R)')
 		},
 
@@ -405,8 +411,23 @@ export default {
 				}
 			}
 
+			let content = ''
+			if (this.model.attributes.audioEnabled) {
+				if (this.disableKeyboardShortcuts) {
+					content = t('spreed', 'Mute audio')
+				} else {
+					content = t('spreed', 'Mute audio (M)')
+				}
+			} else {
+				if (this.disableKeyboardShortcuts) {
+					content = t('spreed', 'Unmute audio')
+				} else {
+					content = t('spreed', 'Unmute audio (M)')
+				}
+			}
+
 			return {
-				content: this.model.attributes.audioEnabled ? t('spreed', 'Mute audio (M)') : t('spreed', 'Unmute audio (M)'),
+				content,
 				show: false,
 			}
 		},
@@ -463,13 +484,25 @@ export default {
 			}
 
 			if (this.model.attributes.videoEnabled) {
+				if (this.disableKeyboardShortcuts) {
+					return t('spreed', 'Disable video')
+				}
+
 				return t('spreed', 'Disable video (V)')
 			}
 
 			if (!this.model.getWebRtc() || !this.model.getWebRtc().connection || this.model.getWebRtc().connection.getSendVideoIfAvailable()) {
+				if (this.disableKeyboardShortcuts) {
+					return t('spreed', 'Enable video')
+				}
+
 				return t('spreed', 'Enable video (V)')
 			}
 
+			if (this.disableKeyboardShortcuts) {
+				return t('spreed', 'Enable video - Your connection will be briefly interrupted when enabling the video for the first time')
+			}
+
 			return t('spreed', 'Enable video (V) - Your connection will be briefly interrupted when enabling the video for the first time')
 		},
 
@@ -646,6 +679,9 @@ export default {
 			return this.$store.getters.isGrid
 		},
 
+		disableKeyboardShortcuts() {
+			return OCP.Accessibility.disableKeyboardShortcuts()
+		},
 	},
 
 	watch: {
diff --git a/src/components/NewMessageForm/AdvancedInput/AdvancedInput.vue b/src/components/NewMessageForm/AdvancedInput/AdvancedInput.vue
index b81aacf6d51..1f6da2a6ae9 100644
--- a/src/components/NewMessageForm/AdvancedInput/AdvancedInput.vue
+++ b/src/components/NewMessageForm/AdvancedInput/AdvancedInput.vue
@@ -75,7 +75,7 @@
 			</span>
 		</template>
 		<div ref="contentEditable"
-			v-shortkey.once="['c']"
+			v-shortkey.once="disableKeyboardShortcuts ? null : ['c']"
 			:contenteditable="activeInput"
 			:placeHolder="placeholderText"
 			role="textbox"
@@ -208,6 +208,13 @@ export default {
 			required: true,
 		},
 	},
+
+	computed: {
+		disableKeyboardShortcuts() {
+			return OCP.Accessibility.disableKeyboardShortcuts()
+		},
+	},
+
 	data() {
 		return {
 			text: '',
diff --git a/src/components/SettingsDialog/SettingsDialog.vue b/src/components/SettingsDialog/SettingsDialog.vue
index 5a0eb0330cb..44cf83ec213 100644
--- a/src/components/SettingsDialog/SettingsDialog.vue
+++ b/src/components/SettingsDialog/SettingsDialog.vue
@@ -76,7 +76,8 @@
 				{{ t('spreed', 'Sounds for chat and call notifications can be adjusted in the personal settings.') }} ↗
 			</a>
 		</NcAppSettingsSection>
-		<NcAppSettingsSection id="shortcuts"
+		<NcAppSettingsSection v-if="!disableKeyboardShortcuts"
+			id="shortcuts"
 			:title="t('spreed', 'Keyboard shortcuts')">
 			<em>{{ t('spreed', 'Speed up your Talk experience with these quick shortcuts.') }}</em>
 
@@ -199,6 +200,10 @@ export default {
 		settingsUrl() {
 			return generateUrl('/settings/user/notifications')
 		},
+
+		disableKeyboardShortcuts() {
+			return OCP.Accessibility.disableKeyboardShortcuts()
+		},
 	},
 
 	mounted() {
diff --git a/src/components/TopBar/TopBar.vue b/src/components/TopBar/TopBar.vue
index fc9ea58c450..d4d4a480307 100644
--- a/src/components/TopBar/TopBar.vue
+++ b/src/components/TopBar/TopBar.vue
@@ -70,7 +70,7 @@
 
 			<!-- sidebar toggle -->
 			<NcActions v-if="!isSidebar"
-				v-shortkey.once="['f']"
+				v-shortkey.once="disableKeyboardShortcuts ? null : ['f']"
 				class="top-bar__button"
 				:aria-label="t('spreed', 'Conversation actions')"
 				:container="container"
@@ -361,6 +361,10 @@ export default {
 				return !peer.sessionIds.length
 			} else return false
 		},
+
+		disableKeyboardShortcuts() {
+			return OCP.Accessibility.disableKeyboardShortcuts()
+		},
 	},
 
 	watch: {