diff --git a/morpheus/cli/commands.py b/morpheus/cli/commands.py
index 99df8e1ff5..21c134657c 100644
--- a/morpheus/cli/commands.py
+++ b/morpheus/cli/commands.py
@@ -288,13 +288,22 @@ def install(**kwargs):
               type=bool,
               help=("Whether or not to use C++ node and message types or to prefer python. "
                     "Only use as a last resort if bugs are encountered"))
+@click.option('--manual_seed',
+              default=None,
+              type=click.IntRange(min=1),
+              envvar="MORPHEUS_MANUAL_SEED",
+              help=("Manually seed the random number generators used by Morpheus, useful for testing."))
 @prepare_command(parse_config=True)
 def run(ctx: click.Context, **kwargs):
     """Run subcommand, used for running a pipeline"""
     # Since the option isnt the same name as `should_use_cpp` anymore, manually set the value here.
     CppConfig.set_should_use_cpp(kwargs.pop("use_cpp", CppConfig.get_should_use_cpp()))
 
-    pass
+    manual_seed_val = kwargs.pop("manual_seed", None)
+    if manual_seed_val is not None:
+        from morpheus.utils.seed import manual_seed
+        logger.debug("Manually seeding random number generators to %d", manual_seed_val)
+        manual_seed(manual_seed_val)
 
 
 @click.group(chain=True,
diff --git a/tests/test_cli.py b/tests/test_cli.py
index 3cb0efea43..aef467bf84 100755
--- a/tests/test_cli.py
+++ b/tests/test_cli.py
@@ -16,6 +16,7 @@
 
 import os
 import shutil
+from unittest import mock
 
 import click
 import mlflow
@@ -157,6 +158,24 @@ def test_autocomplete(self, tmp_path):
                                env={'HOME': str(tmp_path)})
         assert result.exit_code == 0, result.output
 
+    @pytest.mark.usefixtures("restore_environ")
+    @pytest.mark.parametrize('use_environ', [True, False])
+    @pytest.mark.parametrize('value', [1, 13, 33])
+    @mock.patch('morpheus.utils.seed.manual_seed')
+    def test_manual_seed(self, mock_manual_seed: mock.MagicMock, value: int, use_environ: bool):
+        flags = ['run']
+        if use_environ:
+            os.environ['MORPHEUS_MANUAL_SEED'] = str(value)
+        else:
+            flags.append(f'--manual_seed={value}')
+
+        flags.append('pipeline-other')
+
+        runner = CliRunner()
+        result = runner.invoke(commands.cli, flags)
+        assert result.exit_code == 0, result.output
+        mock_manual_seed.assert_called_once_with(value)
+
     @pytest.mark.replace_callback('pipeline_ae')
     def test_pipeline_ae(self, config, callback_values):
         """