[NTR-cxg]type IIx muscle cell

[jychien]

I am currently working with the author of https://doi.org/10.1101/2024.05.15.594276. (@sebozzie)

Preferred term label
type IIx muscle cell

Synonym(s)
type 2x muscle cell, type 2x muscle fiber, type IIx muscle fiber

Definition
A fast type II muscle cell that utilize both the oxidative and glycolytic pathways for metabolism. These cells are distinguished by the expression of myosin heavy chain 1 (MYH1).

Parent cell type term
CL:0002212: type II muscle cell

Anatomical structure where the cell type is found
UBERON:0001134: skeletal muscle tissue

Additional notes or concerns

• https://doi.org/10.1101/2024.05.15.594276: "Within the myonuclei population type IIB, IIX and IIA myonuclei were distinguishable based on the expression of Myh4, Myh1 and Myh2, respectively"
• https://doi.org/10.1186/s13395-021-00279-0: "We provide and analyze a resource dataset based on relatively pure fibers, containing at least 80% of either MYH7 (marker of slow type 1 fibers), MYH2 (marker of fast 2A fibers), or MYH1 (marker of fast 2X fibers)."