[NTR] luminal endometrial unciliated epithelial cell

[Caroline-99]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

This term was requested in the Reproductive System Jamboree
Related #1760

Preferred term label
luminal endometrial unciliated epithelial cell

Synonyms (add reference(s), please)
endometrial luminal epithelial cell - Broad - PMID: 31317179
luminal epithelium cell - PMID: 36581776
luminal cell of endometrium - Broad

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell provides a barrier between the uterine environment and the embryo, undergoes cyclical changes in response to hormones during the menstrual cycle, and plays a crucial role in embryo implantation. Characterized by its tall columnar shape, this cell transforms during the window of implantation into a short columnar or cuboidal cell, loses polarity, and becomes receptive to blastocyst implantation.

PMID: 32929266
PMID: 38559249
PMID: 36581776
PMID: 39198675

Comments section

Throughout the menstrual cycle, luminal cell of endometrium undergoes significant structural changes: proliferating under estrogen during the proliferative phase to thicken the endometrial lining and differentiating under progesterone during the secretory phase to prepare for potential implantation. This cell expresses WNT7A, and LGR5 during the proliferative phase, transitioning to express VTCN1 and SULT1E1 in the early secretory phase, and LEFTY1, IL6, and PTGS1 in the mid- to late-secretory phases.

PMID: 36581776
PMID: 39198675

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
epithelial cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
endometrium luminal epithelium

GO - secretion by cell

Your ORCID

Additional notes or concerns